indole-3-carbinol has been researched along with Hypertension in 14 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertension was induced in cyp1a1ren-2 transgenic rats by feeding indole-3-carbinol (n = 10) and in Fischer 344 rats by subcutaneously infusing ANG II (n = 7)." | 7.77 | Angiotensin II-dependent hypertension causes reversible changes in the platelet proteome. ( Clemetson, KJ; Gebhard, S; Gesell-Salazar, M; Greinacher, A; Hammer, E; Kuttler, B; Peters, B; Peters, J; Rettig, R; Scharf, C; Steil, L; Völker, U, 2011) |
| "Diabetes was induced with streptozotocin in Cyp1a1mRen2 rats and hypertension was generated by inducing renin transgene expression with dietary indole-3-carbinol (I-3-C) for 28 weeks." | 3.80 | Tight blood glycaemic and blood pressure control in experimental diabetic nephropathy reduces extracellular matrix production without regression of fibrosis. ( Betz, B; Conway, BR; Dobyns, A; Dunbar, DR; Hughes, J; Manning, JR; Mullins, JJ; Sheldrake, TA, 2014) |
| "Hypertension was induced in cyp1a1ren-2 transgenic rats by feeding indole-3-carbinol (n = 10) and in Fischer 344 rats by subcutaneously infusing ANG II (n = 7)." | 3.77 | Angiotensin II-dependent hypertension causes reversible changes in the platelet proteome. ( Clemetson, KJ; Gebhard, S; Gesell-Salazar, M; Greinacher, A; Hammer, E; Kuttler, B; Peters, B; Peters, J; Rettig, R; Scharf, C; Steil, L; Völker, U, 2011) |
| "The present study was performed to characterize the autoregulatory efficiency of renal blood flow and glomerular filtration rate and the pressure-natriuresis relationship in transgenic rats with inducible angiotensin II (ANG II)-dependent hypertension (Cyp1a1-Ren-2 rats)." | 3.75 | Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats. ( Bürgelová, M; Cervenka, L; Erbanová, M; Husková, Z; Kramer, HJ; Mullins, JJ; Rakusan, D; Thumová, M; Vanecková, I; Vanourková, Z, 2009) |
| "3%, w/w for 1112 days) of the aryl hydrocarbon indole-3-carbinol (I3C) to induce slowly developing and malignant hypertension, respectively." | 3.73 | Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. ( Bagatell, SJ; Miller, CS; Mitchell, KD; Mouton, CR; Mullins, JJ; Seth, DM, 2006) |
| "Hypertension is a major health concern in the developed world, and its prevalence increases with advancing age." | 1.51 | Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning. ( Alexander, GE; Barnes, CA; Biwer, LA; Chawla, MK; Coleman, PD; De Both, M; Fitzhugh, MC; Hale, TM; Hoang, LT; Huentelman, M; Mitchell, KD; Trouard, TP; Uprety, AR; Willeman, MN; Zempare, MA, 2019) |
| "25% [w/w] in the diet for 14 d, followed by normal chow for 4 d), we demonstrated that hypertension can be sustained chronically (14 wk) by continuous dosing with I3C (0." | 1.48 | Breeding Characteristics and Dose-dependent Blood Pressure Responses of Transgenic Cyp1a1-Ren2 Rats. ( Clark, BJ; Hannah, AR; Leader, CJ; Sammut, IA; Walker, RJ; Wilkins, GT, 2018) |
| "Hypertension is a prerequisite for advanced diabetic nephropathy in humans, so its rarity in typical rodent models may partly explain their resistance to nephropathy." | 1.38 | Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy. ( Bailey, MA; Bellamy, CO; Conway, BR; Dunbar, DR; Hughes, J; Manning, JR; Mullins, JJ; Rennie, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Cairns, C | 1 |
| Conway, B | 1 |
| Leader, CJ | 1 |
| Clark, BJ | 1 |
| Hannah, AR | 1 |
| Sammut, IA | 1 |
| Wilkins, GT | 1 |
| Walker, RJ | 1 |
| Willeman, MN | 1 |
| Chawla, MK | 1 |
| Zempare, MA | 1 |
| Biwer, LA | 1 |
| Hoang, LT | 1 |
| Uprety, AR | 1 |
| Fitzhugh, MC | 1 |
| De Both, M | 1 |
| Coleman, PD | 1 |
| Trouard, TP | 1 |
| Alexander, GE | 1 |
| Mitchell, KD | 2 |
| Barnes, CA | 1 |
| Hale, TM | 1 |
| Huentelman, M | 1 |
| Heijnen, BF | 2 |
| Pelkmans, LP | 1 |
| Danser, AH | 1 |
| Garrelds, IM | 1 |
| Mullins, JJ | 8 |
| De Mey, JG | 1 |
| Struijker-Boudier, HA | 2 |
| Janssen, BJ | 2 |
| Conway, BR | 2 |
| Betz, B | 1 |
| Sheldrake, TA | 1 |
| Manning, JR | 2 |
| Dunbar, DR | 2 |
| Dobyns, A | 1 |
| Hughes, J | 2 |
| Sporková, A | 1 |
| Jíchová, S | 1 |
| Husková, Z | 2 |
| Kopkan, L | 1 |
| Nishiyama, A | 1 |
| Hwang, SH | 1 |
| Hammock, BD | 1 |
| Imig, JD | 1 |
| Kompanowska-Jezierska, E | 1 |
| Sadowski, J | 1 |
| Kramer, HJ | 2 |
| Cervenka, L | 2 |
| Chang, AS | 1 |
| Grant, R | 1 |
| Tomita, H | 1 |
| Kim, HS | 1 |
| Smithies, O | 1 |
| Kakoki, M | 1 |
| Erbanová, M | 1 |
| Thumová, M | 1 |
| Vanecková, I | 1 |
| Vanourková, Z | 1 |
| Bürgelová, M | 1 |
| Rakusan, D | 1 |
| Peters, J | 3 |
| Schlüter, T | 1 |
| Riegel, T | 1 |
| Peters, BS | 1 |
| Beineke, A | 1 |
| Maschke, U | 1 |
| Hosten, N | 1 |
| Rettig, R | 2 |
| Gebhard, S | 1 |
| Steil, L | 1 |
| Peters, B | 2 |
| Gesell-Salazar, M | 1 |
| Hammer, E | 1 |
| Kuttler, B | 1 |
| Clemetson, KJ | 1 |
| Scharf, C | 1 |
| Völker, U | 1 |
| Greinacher, A | 1 |
| Peutz-Kootstra, CJ | 1 |
| Rennie, J | 1 |
| Bailey, MA | 1 |
| Bellamy, CO | 1 |
| Bagatell, SJ | 1 |
| Miller, CS | 1 |
| Mouton, CR | 1 |
| Seth, DM | 1 |
| Kantachuvesiri, S | 1 |
| Fleming, S | 1 |
| Brooker, G | 1 |
| Lammie, AG | 1 |
| McGrath, I | 1 |
| Kotelevtsev, Y | 1 |
14 other studies available for indole-3-carbinol and Hypertension
| Article | Year |
|---|---|
Modeling Human Diabetic Kidney Disease by Combining Hyperglycemia and Hypertension in a Transgenic Rodent Model.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inducers; Diabetes Mellitus, Experimental; | 2020 |
Breeding Characteristics and Dose-dependent Blood Pressure Responses of Transgenic Cyp1a1-Ren2 Rats.
Topics: Animals; Breeding; Cytochrome P-450 CYP1A1; Disease Models, Animal; Female; Hypertension; Indoles; M | 2018 |
Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning.
Topics: Animals; Behavior, Animal; Blood Pressure; Brain; Cytochrome P-450 CYP1A1; Disease Models, Animal; H | 2019 |
Cardiac remodeling during and after renin-angiotensin system stimulation in Cyp1a1-Ren2 transgenic rats.
Topics: Aging; Animals; Cardiomegaly; Cytochrome P-450 CYP1A1; Heart; Hypertension; Indoles; Male; Myocardiu | 2014 |
Tight blood glycaemic and blood pressure control in experimental diabetic nephropathy reduces extracellular matrix production without regression of fibrosis.
Topics: Albuminuria; Animals; Biomarkers; Blood Glucose; Blood Pressure; Cytochrome P-450 CYP1A1; Diabetes M | 2014 |
Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cytochrome P-450 CYP1A1; Epoxide H | 2014 |
Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase.
Topics: Animals; Blood Pressure; Female; Gene Expression; Humans; Hypertension; Indoles; Male; Mice, Knockou | 2016 |
Impairment of the autoregulation of renal hemodynamics and of the pressure-natriuresis relationship precedes the development of hypertension in Cyp1a1-Ren-2 transgenic rats.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cytoc | 2009 |
Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism.
Topics: Administration, Oral; Aldosterone; Animals; Cardiomegaly; Collagen Type I; Cytochrome P-450 CYP1A1; | 2009 |
Angiotensin II-dependent hypertension causes reversible changes in the platelet proteome.
Topics: Aldosterone; Angiotensin II; Animals; Animals, Genetically Modified; Blood Platelets; Humans; Hypert | 2011 |
Transient renin-angiotensin system stimulation in an early stage of life causes sustained hypertension in rats.
Topics: Age Factors; Animals; Arteries; Blood Pressure; Disease Models, Animal; Gene Expression; Glomerulosc | 2011 |
Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy.
Topics: Albuminuria; Animals; Comorbidity; Cytochrome P-450 CYP1A1; Diabetes Mellitus, Experimental; Diabeti | 2012 |
Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Gen | 2006 |
Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Animals; Animals, Genetically Modified; Antioxidants; Bl | 2001 |