indole-3-carbinol has been researched along with Hypertension, Malignant in 9 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Hypertension, Malignant: A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenofibrate treatment significantly attenuated the course of malignant hypertension in I3C-induced CYP1a1-Ren-2 transgenic rats, and the mechanism responsible for antihypertensive action was fenofibrate-induced suppression of renin-angiotensin system activity." | 7.83 | Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats. ( Červenka, L; Doleželová, Š; Jíchová, Š; Kompanowska-Jezierska, E; Kopkan, L; Sadowski, J, 2016) |
| "Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene using indole-3-carbinol (I3C), a natural xenobiotic." | 3.83 | Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. ( Červenka, L; Doleželová, Š; Falck, JR; Husková, Z; Imig, JD; Jíchová, Š; Kompanowska-Jezierska, E; Kopkan, L; Kramer, HJ; Kujal, P; Neckář, J; Reddy, RN; Sadowski, J; Vernerová, Z, 2016) |
| "Fenofibrate treatment significantly attenuated the course of malignant hypertension in I3C-induced CYP1a1-Ren-2 transgenic rats, and the mechanism responsible for antihypertensive action was fenofibrate-induced suppression of renin-angiotensin system activity." | 3.83 | Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats. ( Červenka, L; Doleželová, Š; Jíchová, Š; Kompanowska-Jezierska, E; Kopkan, L; Sadowski, J, 2016) |
| "30% indole-3-carbinol (I3C) to Cyp1a1-Ren2 transgenic rats (TGRs) generates angiotensin II (ANG II)-dependent malignant hypertension (HTN) and increased renal vascular resistance." | 3.79 | Renal nitric oxide synthase and antioxidant preservation in Cyp1a1-Ren-2 transgenic rats with inducible malignant hypertension. ( Baylis, C; Cunningham, MW; Milani, CJ; Mitchell, KD; Sasser, JM; West, CA, 2013) |
| "The present study was performed to assess the effects of the platelet-derived growth factor (PDGF) receptor kinase inhibitor imatinib mesylate on the renal morphological changes occurring during the development of malignant hypertension in transgenic rats with inducible expression of the Ren2 gene [TGR(Cyp1a1Ren2)]." | 3.78 | Imatinib ameliorates renal morphological changes in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension. ( Graciano, ML; Mitchell, KD, 2012) |
| "To determine whether in the transgenic rat model [TGR(Cyp1a1Ren2)] with inducible ANG II-dependent malignant hypertension changes in the activation of intrarenal renin-angiotensin system may contribute to the pathogenesis of hypertension, we examined the gene expression of angiotensinogen (AGT) in renal cortical tissues and renin and prorenin receptor [(P)RR] in the collecting duct (CD) of the kidneys from Cyp1a1Ren2 rats (n = 6) fed a normal diet containing 0." | 3.77 | Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension. ( Kavanagh, KL; Liu, L; Mitchell, KD; Mullins, JJ; Prieto, MC; Williams, DE, 2011) |
| "3%, w/w for 1112 days) of the aryl hydrocarbon indole-3-carbinol (I3C) to induce slowly developing and malignant hypertension, respectively." | 3.73 | Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. ( Bagatell, SJ; Miller, CS; Mitchell, KD; Mouton, CR; Mullins, JJ; Seth, DM, 2006) |
| "Treatment with losartan completely prevented the impaired autoregulation and pressure-natriuresis relationship as well as the development of hypertension in I3C-induced rats." | 1.37 | Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. ( Cervenka, L; Chábová, VC; Hammock, BD; Honetschlägerová, Z; Husková, Z; Hwang, SH; Imig, JD; Kopkan, L; Kramer, HJ; Kujal, P; Sporková, A; Tesař, V; Vernerová, Z, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cunningham, MW | 1 |
| Sasser, JM | 1 |
| West, CA | 1 |
| Milani, CJ | 1 |
| Baylis, C | 1 |
| Mitchell, KD | 6 |
| Jíchová, Š | 2 |
| Kopkan, L | 3 |
| Husková, Z | 2 |
| Doleželová, Š | 2 |
| Neckář, J | 1 |
| Kujal, P | 2 |
| Vernerová, Z | 2 |
| Kramer, HJ | 2 |
| Sadowski, J | 2 |
| Kompanowska-Jezierska, E | 2 |
| Reddy, RN | 1 |
| Falck, JR | 1 |
| Imig, JD | 2 |
| Červenka, L | 3 |
| Prieto, MC | 1 |
| Williams, DE | 1 |
| Liu, L | 1 |
| Kavanagh, KL | 1 |
| Mullins, JJ | 4 |
| Honetschlägerová, Z | 1 |
| Sporková, A | 1 |
| Hwang, SH | 1 |
| Hammock, BD | 1 |
| Chábová, VC | 1 |
| Tesař, V | 1 |
| Graciano, ML | 1 |
| Bagatell, SJ | 1 |
| Miller, CS | 1 |
| Mouton, CR | 1 |
| Seth, DM | 1 |
| Patterson, ME | 1 |
9 other studies available for indole-3-carbinol and Hypertension, Malignant
| Article | Year |
|---|---|
Renal nitric oxide synthase and antioxidant preservation in Cyp1a1-Ren-2 transgenic rats with inducible malignant hypertension.
Topics: Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Cytochrome P-450 CYP1A1; Glomerular Filtr | 2013 |
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.
Topics: 8,11,14-Eicosatrienoic Acid; Albuminuria; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Cy | 2016 |
Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats.
Topics: Animals; Blood Pressure; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP4A; Fenofibrate; Glomerular Fi | 2016 |
Enhancement of renin and prorenin receptor in collecting duct of Cyp1a1-Ren2 rats may contribute to development and progression of malignant hypertension.
Topics: Angiotensin II; Angiotensinogen; Animals; Cytochrome P-450 CYP1A1; Gene Expression; Hypertension, Ma | 2011 |
Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cytochrome P-450 CYP1A1; Disease M | 2011 |
Imatinib ameliorates renal morphological changes in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.
Topics: Albuminuria; Angiotensin II; Animals; Benzamides; Cytochrome P-450 CYP1A1; Hypertension, Malignant; | 2012 |
Enhanced tubuloglomerular feedback in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Benzimidazoles; Biphenyl Compounds; Cytochro | 2005 |
Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Gen | 2006 |
Renoprotective effects of neuronal NOS-derived nitric oxide and cyclooxygenase-2 metabolites in transgenic rats with inducible malignant hypertension.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Blood Pressure; Citrulline; Cyclooxygenase 2 | 2008 |