indole-3-carbinol has been researched along with Disease Models, Animal in 45 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed the development of nanocapsules (NCs) for oral indole-3-carbinol (I3C) administration and evaluation of antinociceptive potential of this compound in its two forms, free and nanoencapsulated, using acute pain models." | 7.88 | Nanocapsules improve indole-3-carbinol photostability and prolong its antinociceptive action in acute pain animal models. ( Barbieri, AV; Cruz, L; Farago, PV; Ferreira, LM; Gehrcke, M; Giuliani, LM; Nadal, JM; Nogueira, CW; Prado, VC; Sari, MHM, 2018) |
| " In this study, we examined the beneficial effects of 3,3'-diindolylmethane (DIM) and indole-3-carbinol (I3C), dietary components found in cruciferous vegetables, on brain inflammation." | 7.80 | 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation. ( Choi, BR; Han, JS; Kim, HW; Kim, J; Lee, HJ; Lee, KW; Lee, S, 2014) |
| " Together, these findings indicate that OSU-A9 is a potent, orally bioavailable inhibitor of the Akt-NF-kappaB signaling network with a broad spectrum of antitumor activity that includes targets regulating multiple aspects of HCC pathogenesis and progression." | 5.35 | Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. ( Chen, CS; Kulp, SK; Omar, HA; Patel, T; Sargeant, AM; Wang, D; Weng, JR, 2009) |
| "Indole-3-carbinol (I3C) is reported to have neuroprotective properties in an animal model of ischemic stroke." | 4.12 | Pharmacokinetic and Pharmacodynamic Properties of Indole-3-carbinol in Experimental Focal Ischemic Injury. ( Jain, SK; Krishnamurthy, S; Ramakrishna, K, 2022) |
| " We now show that during pregnancy, administration of a diet rich in the aryl hydrocarbon receptor (AHR) ligand indole-3-carbinole (I3C), or of breast milk, activates AHR and prevents NEC in newborn mice by reducing Toll-like receptor 4 (TLR4) signaling in the newborn gut." | 4.02 | Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis. ( Fulton, WB; Hackam, DJ; Jia, H; Kovler, ML; Lu, P; Prindle, T; Salazar, AG; Sampah, M; Sodhi, CP; Wang, S; Wipf, P; Yamaguchi, Y; Zhou, Q, 2021) |
| "Indole-3-carbinol (I3C) and other aryl hydrocarbon receptor agonists are known to modulate the immune system and ameliorate various inflammatory and autoimmune diseases in animal models, including colitis induced by dextran sulfate sodium (DSS)." | 3.96 | Immune and microRNA responses to ( Alkarkoushi, RR; Bam, M; Chatzistamou, I; Hui, Y; Nagarkatti, M; Nagarkatti, P; Singh, U; Tavakoli, AS; Testerman, TL, 2020) |
| "This study aimed the development of nanocapsules (NCs) for oral indole-3-carbinol (I3C) administration and evaluation of antinociceptive potential of this compound in its two forms, free and nanoencapsulated, using acute pain models." | 3.88 | Nanocapsules improve indole-3-carbinol photostability and prolong its antinociceptive action in acute pain animal models. ( Barbieri, AV; Cruz, L; Farago, PV; Ferreira, LM; Gehrcke, M; Giuliani, LM; Nadal, JM; Nogueira, CW; Prado, VC; Sari, MHM, 2018) |
| "Our data reveal for the first time that the ingestion of indole-3-carbinol, as administered, diminishes proliferation and increases apoptosis of tumor cells in an experimental model of inflammatory breast cancer, although this effect could not be enough to avoid the appearance of tumor embolization and metastasis." | 3.88 | Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer. ( Cáceres, S; Díez-Córdova, LT; González-Gil, A; Illera, JC; Martín-Ruiz, A; Peña, L, 2018) |
| " In this study, we examined the beneficial effects of 3,3'-diindolylmethane (DIM) and indole-3-carbinol (I3C), dietary components found in cruciferous vegetables, on brain inflammation." | 3.80 | 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation. ( Choi, BR; Han, JS; Kim, HW; Kim, J; Lee, HJ; Lee, KW; Lee, S, 2014) |
| "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, affecting almost 32% of the population and ranging from simple steatosis to nonalcoholic steatohepatitis (NASH)." | 1.91 | Indole-3-carbinol and chlorogenic acid combination modulates gut microbiome and attenuates nonalcoholic steatohepatitis in a murine model. ( Bacil, GP; Barbisan, LF; Rodrigues, J; Romualdo, GR, 2023) |
| "Hypertension is a major health concern in the developed world, and its prevalence increases with advancing age." | 1.51 | Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning. ( Alexander, GE; Barnes, CA; Biwer, LA; Chawla, MK; Coleman, PD; De Both, M; Fitzhugh, MC; Hale, TM; Hoang, LT; Huentelman, M; Mitchell, KD; Trouard, TP; Uprety, AR; Willeman, MN; Zempare, MA, 2019) |
| "25% [w/w] in the diet for 14 d, followed by normal chow for 4 d), we demonstrated that hypertension can be sustained chronically (14 wk) by continuous dosing with I3C (0." | 1.48 | Breeding Characteristics and Dose-dependent Blood Pressure Responses of Transgenic Cyp1a1-Ren2 Rats. ( Clark, BJ; Hannah, AR; Leader, CJ; Sammut, IA; Walker, RJ; Wilkins, GT, 2018) |
| " This population potentially may be susceptible to supplements' adverse effects." | 1.46 | Reversible Toxic Effects of the Dietary Supplement Indole-3-Carbinol in an Immune Compromised Rodent Model: Intestine as the Main Target. ( Fletcher, A; Huang, H; Pham, Q; Wang, TT; Yu, L, 2017) |
| "Hypertension is a prerequisite for advanced diabetic nephropathy in humans, so its rarity in typical rodent models may partly explain their resistance to nephropathy." | 1.38 | Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy. ( Bailey, MA; Bellamy, CO; Conway, BR; Dunbar, DR; Hughes, J; Manning, JR; Mullins, JJ; Rennie, J, 2012) |
| "Treatment with losartan completely prevented the impaired autoregulation and pressure-natriuresis relationship as well as the development of hypertension in I3C-induced rats." | 1.37 | Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. ( Cervenka, L; Chábová, VC; Hammock, BD; Honetschlägerová, Z; Husková, Z; Hwang, SH; Imig, JD; Kopkan, L; Kramer, HJ; Kujal, P; Sporková, A; Tesař, V; Vernerová, Z, 2011) |
| " Together, these findings indicate that OSU-A9 is a potent, orally bioavailable inhibitor of the Akt-NF-kappaB signaling network with a broad spectrum of antitumor activity that includes targets regulating multiple aspects of HCC pathogenesis and progression." | 1.35 | Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. ( Chen, CS; Kulp, SK; Omar, HA; Patel, T; Sargeant, AM; Wang, D; Weng, JR, 2009) |
| "We examined the effect of I3C on prostate cancer in a well-defined R3327 model using Copenhagen rats and the transplantable cell line, MAT-LyLu." | 1.33 | Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. ( Ashok, BT; Chen, YG; Garikapaty, VP; Iatropoulos, M; Mittelman, A; Tiwari, RK, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.44) | 18.2507 |
| 2000's | 16 (35.56) | 29.6817 |
| 2010's | 16 (35.56) | 24.3611 |
| 2020's | 11 (24.44) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ramakrishna, K | 1 |
| Jain, SK | 1 |
| Krishnamurthy, S | 2 |
| Bacil, GP | 1 |
| Romualdo, GR | 1 |
| Rodrigues, J | 1 |
| Barbisan, LF | 1 |
| Busbee, PB | 1 |
| Menzel, L | 1 |
| Alrafas, HR | 1 |
| Dopkins, N | 1 |
| Becker, W | 1 |
| Miranda, K | 1 |
| Tang, C | 1 |
| Chatterjee, S | 1 |
| Singh, U | 2 |
| Nagarkatti, M | 2 |
| Nagarkatti, PS | 1 |
| Liu, WC | 1 |
| Chen, PH | 1 |
| Chen, LW | 1 |
| Alkarkoushi, RR | 1 |
| Hui, Y | 1 |
| Tavakoli, AS | 1 |
| Nagarkatti, P | 1 |
| Chatzistamou, I | 1 |
| Bam, M | 1 |
| Testerman, TL | 1 |
| Wu, Y | 1 |
| Wang, J | 1 |
| He, Q | 1 |
| Yu, L | 3 |
| Pham, Q | 2 |
| Cheung, L | 1 |
| Zhang, Z | 1 |
| Kim, YS | 1 |
| Smith, AD | 1 |
| Wang, TTY | 1 |
| Guzmán-Navarro, G | 1 |
| León, MB | 1 |
| Martín-Estal, I | 1 |
| Durán, RC | 1 |
| Villarreal-Alvarado, L | 1 |
| Vaquera-Vázquez, A | 1 |
| Cuevas-Cerda, T | 1 |
| Garza-García, K | 1 |
| Cuervo-Pérez, LE | 1 |
| Barbosa-Quintana, Á | 1 |
| Pérez-Saucedo, JE | 1 |
| Lara-Díaz, VJ | 1 |
| Castorena-Torres, F | 1 |
| Kahalehili, HM | 1 |
| Newman, NK | 1 |
| Pennington, JM | 1 |
| Kolluri, SK | 1 |
| Kerkvliet, NI | 1 |
| Shulzhenko, N | 1 |
| Morgun, A | 1 |
| Ehrlich, AK | 1 |
| Lu, P | 1 |
| Yamaguchi, Y | 1 |
| Fulton, WB | 1 |
| Wang, S | 1 |
| Zhou, Q | 1 |
| Jia, H | 1 |
| Kovler, ML | 1 |
| Salazar, AG | 1 |
| Sampah, M | 1 |
| Prindle, T | 1 |
| Wipf, P | 1 |
| Sodhi, CP | 1 |
| Hackam, DJ | 1 |
| Nolan, LS | 1 |
| Mihi, B | 1 |
| Agrawal, P | 1 |
| Gong, Q | 1 |
| Rimer, JM | 1 |
| Bidani, SS | 1 |
| Gale, SE | 1 |
| Goree, M | 1 |
| Hu, E | 1 |
| Lanik, WE | 1 |
| Huang, E | 1 |
| Bando, JK | 1 |
| Liu, V | 1 |
| Lewis, AN | 1 |
| Bustos, A | 1 |
| Hodzic, Z | 1 |
| Laury, ML | 1 |
| Good, M | 1 |
| Gehrcke, M | 1 |
| Sari, MHM | 1 |
| Ferreira, LM | 1 |
| Barbieri, AV | 1 |
| Giuliani, LM | 1 |
| Prado, VC | 1 |
| Nadal, JM | 1 |
| Farago, PV | 1 |
| Nogueira, CW | 1 |
| Cruz, L | 1 |
| Choi, Y | 1 |
| Abdelmegeed, MA | 1 |
| Song, BJ | 1 |
| Paliwal, P | 1 |
| Chauhan, G | 1 |
| Gautam, D | 1 |
| Dash, D | 1 |
| Patne, SCU | 1 |
| Martín-Ruiz, A | 1 |
| Peña, L | 1 |
| González-Gil, A | 1 |
| Díez-Córdova, LT | 1 |
| Cáceres, S | 1 |
| Illera, JC | 1 |
| Leader, CJ | 1 |
| Clark, BJ | 1 |
| Hannah, AR | 1 |
| Sammut, IA | 1 |
| Wilkins, GT | 1 |
| Walker, RJ | 1 |
| Willeman, MN | 1 |
| Chawla, MK | 1 |
| Zempare, MA | 1 |
| Biwer, LA | 1 |
| Hoang, LT | 1 |
| Uprety, AR | 1 |
| Fitzhugh, MC | 1 |
| De Both, M | 1 |
| Coleman, PD | 1 |
| Trouard, TP | 1 |
| Alexander, GE | 1 |
| Mitchell, KD | 2 |
| Barnes, CA | 1 |
| Hale, TM | 1 |
| Huentelman, M | 1 |
| Jiang, J | 1 |
| Kang, TB | 1 |
| Shim, do W | 1 |
| Oh, NH | 1 |
| Kim, TJ | 1 |
| Lee, KH | 1 |
| Kim, HW | 1 |
| Kim, J | 2 |
| Lee, S | 1 |
| Choi, BR | 1 |
| Han, JS | 1 |
| Lee, KW | 1 |
| Lee, HJ | 1 |
| Deng, W | 1 |
| Wei, L | 1 |
| Zong, J | 1 |
| Bian, Z | 1 |
| Zhou, H | 1 |
| Zhang, R | 1 |
| Tang, Q | 1 |
| Fujioka, N | 1 |
| Fritz, V | 1 |
| Upadhyaya, P | 1 |
| Kassie, F | 1 |
| Hecht, SS | 1 |
| Julliard, W | 1 |
| De Wolfe, TJ | 1 |
| Fechner, JH | 1 |
| Safdar, N | 1 |
| Agni, R | 1 |
| Mezrich, JD | 1 |
| Fletcher, A | 1 |
| Huang, H | 1 |
| Wang, TT | 1 |
| Yan, XJ | 2 |
| Qi, M | 2 |
| Telusma, G | 1 |
| Yancopoulos, S | 1 |
| Madaio, M | 1 |
| Satoh, M | 1 |
| Reeves, WH | 1 |
| Teichberg, S | 2 |
| Kohn, N | 1 |
| Auborn, K | 1 |
| Chiorazzi, N | 2 |
| Omar, HA | 1 |
| Sargeant, AM | 1 |
| Weng, JR | 1 |
| Wang, D | 1 |
| Kulp, SK | 1 |
| Patel, T | 1 |
| Chen, CS | 1 |
| Peters, J | 3 |
| Schlüter, T | 1 |
| Riegel, T | 1 |
| Peters, BS | 1 |
| Beineke, A | 1 |
| Maschke, U | 1 |
| Hosten, N | 1 |
| Mullins, JJ | 6 |
| Rettig, R | 2 |
| Honetschlägerová, Z | 1 |
| Sporková, A | 1 |
| Kopkan, L | 1 |
| Husková, Z | 1 |
| Hwang, SH | 1 |
| Hammock, BD | 1 |
| Imig, JD | 1 |
| Kramer, HJ | 1 |
| Kujal, P | 1 |
| Vernerová, Z | 1 |
| Chábová, VC | 1 |
| Tesař, V | 1 |
| Cervenka, L | 1 |
| Heijnen, BF | 1 |
| Peutz-Kootstra, CJ | 1 |
| Janssen, BJ | 1 |
| Struijker-Boudier, HA | 1 |
| Conway, BR | 1 |
| Rennie, J | 1 |
| Bailey, MA | 1 |
| Dunbar, DR | 1 |
| Manning, JR | 1 |
| Bellamy, CO | 1 |
| Hughes, J | 1 |
| Lu, HF | 1 |
| Tung, WL | 1 |
| Yang, JS | 1 |
| Huang, FM | 1 |
| Lee, CS | 1 |
| Huang, YP | 1 |
| Liao, WY | 1 |
| Chen, YL | 1 |
| Chung, JG | 1 |
| Johnson, F | 1 |
| Huff, J | 1 |
| Auborn, KJ | 1 |
| Chen, D | 1 |
| Madaio, MP | 1 |
| Yoshida, M | 1 |
| Katashima, S | 1 |
| Ando, J | 1 |
| Tanaka, T | 1 |
| Uematsu, F | 1 |
| Nakae, D | 1 |
| Maekawa, A | 1 |
| Garikapaty, VP | 1 |
| Ashok, BT | 1 |
| Chen, YG | 1 |
| Mittelman, A | 1 |
| Iatropoulos, M | 1 |
| Tiwari, RK | 1 |
| Howard, LL | 1 |
| Patterson, ME | 1 |
| Gallagher, EP | 1 |
| Rahman, KM | 1 |
| Sarkar, FH | 1 |
| Banerjee, S | 1 |
| Wang, Z | 1 |
| Liao, DJ | 1 |
| Hong, X | 1 |
| Sarkar, NH | 1 |
| Brosnan, MJ | 1 |
| Peters, B | 2 |
| Grisk, O | 1 |
| Becher, B | 1 |
| Wanka, H | 1 |
| Kuttler, B | 1 |
| Lüdemann, J | 1 |
| Lorenz, G | 1 |
| Oganesian, A | 1 |
| Hendricks, JD | 1 |
| Pereira, CB | 1 |
| Orner, GA | 2 |
| Bailey, GS | 2 |
| Williams, DE | 1 |
| Exon, JH | 1 |
| South, EH | 1 |
| Xu, M | 1 |
| Stoner, GD | 1 |
| Horio, DT | 1 |
| Dashwood, RH | 1 |
| Kantachuvesiri, S | 1 |
| Fleming, S | 1 |
| Brooker, G | 1 |
| Lammie, AG | 1 |
| McGrath, I | 1 |
| Kotelevtsev, Y | 1 |
| Stoner, G | 1 |
| Casto, B | 1 |
| Ralston, S | 1 |
| Roebuck, B | 1 |
| Pereira, C | 1 |
| Bailey, G | 1 |
| Jang, JJ | 1 |
| Cho, KJ | 1 |
| Lee, YS | 1 |
| Bae, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blinded, Placebo-Controlled Study With Immunotype Specific Dietary Supplements to Improve Inflammatory Age® by Edifice Health[NCT04983017] | 750 participants (Anticipated) | Interventional | 2021-08-10 | Recruiting | |||
| A Single-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of 3,3'-Diindolylmethane (BR-DIM) in Patients With Systemic Lupus Erythematosus (SLE)[NCT02483624] | Phase 1 | 6 participants (Actual) | Interventional | 2016-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indole-3-carbinol and Disease Models, Animal
| Article | Year |
|---|---|
Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers; Brassicaceae; Carcinogens; Cell Line, | 2016 |
44 other studies available for indole-3-carbinol and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Pharmacokinetic and Pharmacodynamic Properties of Indole-3-carbinol in Experimental Focal Ischemic Injury.
Topics: Animals; Disease Models, Animal; Indoles; Ischemic Stroke; Rats; Stroke; Tissue Distribution | 2022 |
Indole-3-carbinol and chlorogenic acid combination modulates gut microbiome and attenuates nonalcoholic steatohepatitis in a murine model.
Topics: Animals; Chlorogenic Acid; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Mice; Non-al | 2023 |
Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner.
Topics: Animals; Butyric Acid; Colitis; Colon; Disease Models, Animal; Dysbiosis; Female; Gastrointestinal M | 2020 |
Supplementation of endogenous Ahr ligands reverses insulin resistance and associated inflammation in an insulin-dependent diabetic mouse model.
Topics: Animals; Cell Adhesion Molecules; Diabetes Mellitus; Dietary Supplements; Disease Models, Animal; Hu | 2020 |
Immune and microRNA responses to
Topics: Animals; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Helicobacter; Humans; I | 2020 |
Dietary Indole-3-Carbinol Alleviated Spleen Enlargement, Enhanced IgG Response in C3H/HeN Mice Infected with
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Brassicaceae; Citrobacter rodentium; Cytok | 2020 |
Prenatal indole-3-carbinol administration activates aryl hydrocarbon receptor-responsive genes and attenuates lung injury in a bronchopulmonary dysplasia model.
Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Cytokines; Disease Models, Animal; Female; Fi | 2021 |
Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice.
Topics: Animals; Bacteria; Basic Helix-Loop-Helix Transcription Factors; Diabetes Mellitus, Type 1; Dietary | 2020 |
Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis.
Topics: Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Cytochrome P-450 CYP1A1; Di | 2021 |
Indole-3-Carbinol-Dependent Aryl Hydrocarbon Receptor Signaling Attenuates the Inflammatory Response in Experimental Necrotizing Enterocolitis.
Topics: Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors; Disease Models, Animal; Ent | 2021 |
Nanocapsules improve indole-3-carbinol photostability and prolong its antinociceptive action in acute pain animal models.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug S | 2018 |
Preventive effects of indole-3-carbinol against alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms: Role of gut-liver-adipose tissue axis.
Topics: Alcoholism; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury, Chronic; Colon | 2018 |
Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model.
Topics: Adenosine Diphosphate; Animals; Behavior, Animal; Carrageenan; Cerebrovascular Circulation; Disease | 2018 |
Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Disease Models, Animal; Dogs; Femal | 2018 |
Breeding Characteristics and Dose-dependent Blood Pressure Responses of Transgenic Cyp1a1-Ren2 Rats.
Topics: Animals; Breeding; Cytochrome P-450 CYP1A1; Disease Models, Animal; Female; Hypertension; Indoles; M | 2018 |
Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning.
Topics: Animals; Behavior, Animal; Blood Pressure; Brain; Cytochrome P-450 CYP1A1; Disease Models, Animal; H | 2019 |
Indole-3-carbinol inhibits LPS-induced inflammatory response by blocking TRIF-dependent signaling pathway in macrophages.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalve | 2013 |
3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antigens, Differentiation; Calcium-Binding Proteins; Cell Death; | 2014 |
Attenuation of cardiac remodeling by indole-3-carbinol in mice is associated with improved energy metabolism.
Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Energy Metabolism; Gene Expression Regulat | 2014 |
Amelioration of Clostridium difficile Infection in Mice by Dietary Supplementation With Indole-3-carbinol.
Topics: Animals; Anti-Bacterial Agents; Bacterial Translocation; Clostridioides difficile; Clostridium Infec | 2017 |
Reversible Toxic Effects of the Dietary Supplement Indole-3-Carbinol in an Immune Compromised Rodent Model: Intestine as the Main Target.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Diet; Dietary Supplements; Disease | 2017 |
Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Autoantibodies; B-Lymphocytes; Cell Differen | 2009 |
Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; | 2009 |
Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism.
Topics: Administration, Oral; Aldosterone; Animals; Cardiomegaly; Collagen Type I; Cytochrome P-450 CYP1A1; | 2009 |
Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cytochrome P-450 CYP1A1; Disease M | 2011 |
Transient renin-angiotensin system stimulation in an early stage of life causes sustained hypertension in rats.
Topics: Age Factors; Animals; Arteries; Blood Pressure; Disease Models, Animal; Gene Expression; Glomerulosc | 2011 |
Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy.
Topics: Albuminuria; Animals; Comorbidity; Cytochrome P-450 CYP1A1; Diabetes Mellitus, Experimental; Diabeti | 2012 |
In vitro suppression of growth of murine WEHI-3 leukemia cells and in vivo promotion of phagocytosis in a leukemia mice model by indole-3-carbinol.
Topics: Animals; Apoptosis; Brassica; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Disease Models, Anim | 2012 |
Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol-. Certain health supplements may cause both carcinogenic and anticarcinogenic effects.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Dietary Supplements; Disease Models, Animal; Food, Or | 2002 |
Lifespan is prolonged in autoimmune-prone (NZB/NZW) F1 mice fed a diet supplemented with indole-3-carbinol.
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Indoles; Kidney; Kidney Diseases | 2003 |
Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism.
Topics: Adenocarcinoma; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Disease Models, Animal; Endome | 2004 |
Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer.
Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Indoles; Lung Neoplasms; Male; Neoplasm Tr | 2005 |
Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Antioxidants; Blood Pressure; Cytochrome P-4 | 2005 |
Using salmonid microarrays to understand the dietary modulation of carcinogenesis in rainbow trout.
Topics: Aflatoxin B1; Animals; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Dose-Response Relation | 2006 |
Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Disease Models, Animal; Female; Hu | 2006 |
Prorenin and glomerulosclerosis?
Topics: Administration, Oral; Animals; Animals, Genetically Modified; Blood Pressure; Disease Models, Animal | 2008 |
Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis.
Topics: Administration, Oral; Aldosterone; Animals; Animals, Genetically Modified; Blood Pressure; Cytochrom | 2008 |
Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study.
Topics: Aflatoxin B1; Animals; Carcinogens; Cocarcinogenesis; Diet; Disease Models, Animal; Dose-Response Re | 1999 |
Dietary indole-3-carbinol alters immune functions in rats.
Topics: Animals; Antibody Formation; Anticarcinogenic Agents; Diet; Disease Models, Animal; Hypersensitivity | 2000 |
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.
Topics: 1,2-Dimethylhydrazine; Adenosarcoma; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcino | 2001 |
Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Animals; Animals, Genetically Modified; Antioxidants; Bl | 2001 |
Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Azoxymethane; Body | 2002 |
Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Topics: Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Disease Models, Animal; Germanium; Indole | 1991 |