indole-3-carbinol has been researched along with Colonic Neoplasms in 16 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male Sprague-Dawley rats were treated orally with indole-3-carbinol (13C) for 7 wk at levels of 150, 100, and 50 mg/kg body weight." | 3.71 | Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats. ( Exon, JH; Hendrix, K; Magnuson, BA; South, EH, 2001) |
| "These results suggest that I3C lowers colon cancer risk through a mechanism not involving reduction of carcinogen activation by CYP2E1." | 1.33 | Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats. ( Gallaher, DD; Plate, AY, 2006) |
| "Treatment with sulforaphane (15 microM), PEITC (10 microM), indole-3-carbinol (10 microM) and 3,3'-diindolylmethane (10 microM) induced PARP cleavage after 24 and 48 h in both 40-16 and the 379." | 1.33 | Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. ( Barillari, J; Bartsch, H; Gerhäuser, C; Iori, R; Lichtenberg, M; Pappa, G, 2006) |
| " Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-term treatment leads to the formation of colonic aberrant crypt foci (ACF)." | 1.30 | Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. ( Dashwood, RH; Xu, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 11 (68.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Moura, NA | 1 |
| Caetano, BFR | 1 |
| de Moraes, LN | 1 |
| Carvalho, RF | 1 |
| Rodrigues, MAM | 1 |
| Barbisan, LF | 1 |
| Nakamura, Y | 1 |
| Yogosawa, S | 1 |
| Izutani, Y | 1 |
| Watanabe, H | 1 |
| Otsuji, E | 1 |
| Sakai, T | 1 |
| Kronbak, R | 1 |
| Duus, F | 2 |
| Vang, O | 2 |
| Hudson, EA | 1 |
| Howells, LM | 1 |
| Gallacher-Horley, B | 1 |
| Fox, LH | 1 |
| Gescher, A | 1 |
| Manson, MM | 1 |
| Neave, AS | 1 |
| Sarup, SM | 1 |
| Seidelin, M | 1 |
| Plate, AY | 1 |
| Gallaher, DD | 1 |
| Suzui, M | 1 |
| Inamine, M | 1 |
| Kaneshiro, T | 1 |
| Morioka, T | 1 |
| Yoshimi, N | 1 |
| Suzuki, R | 1 |
| Kohno, H | 1 |
| Tanaka, T | 1 |
| Pappa, G | 1 |
| Lichtenberg, M | 1 |
| Iori, R | 1 |
| Barillari, J | 1 |
| Bartsch, H | 1 |
| Gerhäuser, C | 1 |
| Wang, R | 1 |
| Dashwood, WM | 1 |
| Bailey, GS | 4 |
| Williams, DE | 1 |
| Dashwood, RH | 6 |
| Guo, D | 1 |
| Schut, HA | 2 |
| Davis, CD | 1 |
| Snyderwine, EG | 1 |
| Xu, M | 4 |
| Bailey, AC | 1 |
| Hernaez, JF | 1 |
| Taoka, CR | 1 |
| Blum, CA | 1 |
| Orner, GA | 2 |
| Fong, AT | 1 |
| Stoner, GD | 2 |
| Horio, DT | 2 |
| Exon, JH | 1 |
| South, EH | 1 |
| Magnuson, BA | 1 |
| Hendrix, K | 1 |
| Stoner, G | 1 |
| Casto, B | 1 |
| Ralston, S | 1 |
| Roebuck, B | 1 |
| Pereira, C | 1 |
| Bailey, G | 1 |
16 other studies available for indole-3-carbinol and Colonic Neoplasms
| Article | Year |
|---|---|
Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Caco-2 Cells; Cadherins; Car | 2018 |
A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy.
Topics: Adenine; Apoptosis; Autophagy; Cell Survival; Colonic Neoplasms; Drug Screening Assays, Antitumor; D | 2009 |
Effect of 4-methoxyindole-3-carbinol on the proliferation of colon cancer cells in vitro, when treated alone or in combination with indole-3-carbinol.
Topics: Cell Cycle; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Drug Therapy, Combination; Humans | 2010 |
Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Biological Transport; Cell Cycle; Cell Di | 2003 |
Characterization of the N-methoxyindole-3-carbinol (NI3C)--induced cell cycle arrest in human colon cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferat | 2005 |
Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats.
Topics: Administration, Oral; Animal Feed; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcin | 2006 |
Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antioxidants; Apoptosis; Cell Cycle; Cell Proliferati | 2005 |
Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Brassicaceae; Caspase 7; Caspase 9; Caspases; Cell Lin | 2006 |
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; beta Catenin; Carcinogens; Chlorophyllides; | 2006 |
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Chlorophyllides; Colon; Colonic Neoplasms; DNA; DNA A | 1995 |
Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Cy | 1996 |
Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Chlorophyllides; Colon; Colonic Neoplasms; | 1999 |
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; beta Catenin; Carcinogens; Chlorophyllides; | 2001 |
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.
Topics: 1,2-Dimethylhydrazine; Adenosarcoma; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcino | 2001 |
Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers; Body Weight; Carcinogens; Cell Division; | 2001 |
Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Azoxymethane; Body | 2002 |