indole-3-carbinol has been researched along with Carcinoma, Hepatocellular in 12 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sorafenib is the only chemotherapeutic agent currently approved for unresectable hepatocellular carcinoma (HCC)." | 7.83 | Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study. ( Abdelmageed, MM; El-Demerdash, E; El-Naga, RN; Elmazar, MM, 2016) |
| "A major obstacle to successful treatment of hepatocellular carcinoma (HCC) is its high resistance to cytotoxic chemotherapy due to overexpression of multidrug resistance genes." | 5.42 | Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. ( Chiang, CL; Ghoshal, K; He, H; Hsu, S; Jacob, ST; Lee, LJ; Lu, Y; Ren, W; Teng, KY; Wang, X; Yang, Z; Yu, B, 2015) |
| " Together, these findings indicate that OSU-A9 is a potent, orally bioavailable inhibitor of the Akt-NF-kappaB signaling network with a broad spectrum of antitumor activity that includes targets regulating multiple aspects of HCC pathogenesis and progression." | 5.35 | Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. ( Chen, CS; Kulp, SK; Omar, HA; Patel, T; Sargeant, AM; Wang, D; Weng, JR, 2009) |
| "Sorafenib is the only chemotherapeutic agent currently approved for unresectable hepatocellular carcinoma (HCC)." | 3.83 | Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study. ( Abdelmageed, MM; El-Demerdash, E; El-Naga, RN; Elmazar, MM, 2016) |
| "The present study investigated and compared the potential chemosensitizing effect of indole-3-carbinol (I3C) and epigallocatechin-3-gallate (EGCG) on TRAIL-induced apoptosis in human hepatocellular carcinoma (HCC) HepG2 cells as well as the possible mechanisms underlying these modulatory effects, particularly their effects on TRAIL death receptors (DR), Bcl-2 and c-FLIP proteins expression." | 3.79 | Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals. ( Abou El Naga, RN; Ammar, el-SM; Azab, SS; El-Demerdash, E; El-Merzabani, M; Shaarawy, S, 2013) |
| "A major obstacle to successful treatment of hepatocellular carcinoma (HCC) is its high resistance to cytotoxic chemotherapy due to overexpression of multidrug resistance genes." | 1.42 | Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. ( Chiang, CL; Ghoshal, K; He, H; Hsu, S; Jacob, ST; Lee, LJ; Lu, Y; Ren, W; Teng, KY; Wang, X; Yang, Z; Yu, B, 2015) |
| " Together, these findings indicate that OSU-A9 is a potent, orally bioavailable inhibitor of the Akt-NF-kappaB signaling network with a broad spectrum of antitumor activity that includes targets regulating multiple aspects of HCC pathogenesis and progression." | 1.35 | Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma. ( Chen, CS; Kulp, SK; Omar, HA; Patel, T; Sargeant, AM; Wang, D; Weng, JR, 2009) |
| "The aim of this study was to investigate the protective effect of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine (NDBA) or N-nitrosopiperidine (NPIP)-induced oxidative DNA damage in the single cell gel electrophoresis (SCGE)/HepG2 assay." | 1.35 | Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. ( Arranz, N; García, A; Haza, AI; Morales, P; Rafter, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, CM | 2 |
| Choi, YJ | 1 |
| Park, SH | 2 |
| Nam, MJ | 2 |
| Hoffman, TE | 1 |
| Acerbo, ER | 1 |
| Carranza, KF | 1 |
| Gilberto, VS | 1 |
| Wallis, LE | 1 |
| Hanneman, WH | 1 |
| Wang, X | 1 |
| He, H | 1 |
| Lu, Y | 1 |
| Ren, W | 1 |
| Teng, KY | 1 |
| Chiang, CL | 1 |
| Yang, Z | 1 |
| Yu, B | 1 |
| Hsu, S | 1 |
| Jacob, ST | 1 |
| Ghoshal, K | 1 |
| Lee, LJ | 1 |
| Abdelmageed, MM | 1 |
| El-Naga, RN | 1 |
| El-Demerdash, E | 2 |
| Elmazar, MM | 1 |
| Omar, HA | 1 |
| Sargeant, AM | 1 |
| Weng, JR | 1 |
| Wang, D | 1 |
| Kulp, SK | 1 |
| Patel, T | 1 |
| Chen, CS | 1 |
| Saw, CL | 1 |
| Cintrón, M | 1 |
| Wu, TY | 1 |
| Guo, Y | 1 |
| Huang, Y | 1 |
| Jeong, WS | 2 |
| Kong, AN | 2 |
| Abou El Naga, RN | 1 |
| Azab, SS | 1 |
| Shaarawy, S | 1 |
| El-Merzabani, M | 1 |
| Ammar, el-SM | 1 |
| Nho, CW | 1 |
| Jeffery, E | 1 |
| Keum, YS | 1 |
| Chen, C | 1 |
| Jain, MR | 1 |
| Shen, G | 1 |
| Kim, JH | 1 |
| Li, W | 1 |
| García, A | 1 |
| Haza, AI | 1 |
| Arranz, N | 1 |
| Rafter, J | 1 |
| Morales, P | 1 |
| Staub, RE | 1 |
| Feng, C | 1 |
| Onisko, B | 1 |
| Bailey, GS | 1 |
| Firestone, GL | 1 |
| Bjeldanes, LF | 1 |
12 other studies available for indole-3-carbinol and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Indole-3-carbinol induces apoptosis in human hepatocellular carcinoma Huh-7 cells.
Topics: Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; | 2018 |
Anticarcinogenic effect of indole-3-carbinol (I3C) on human hepatocellular carcinoma SNU449 cells.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tum | 2019 |
Ultrasensitivity dynamics of diverse aryl hydrocarbon receptor modulators in a hepatoma cell line.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Hazardous Substances; Indoles; | 2019 |
Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; D | 2015 |
Indole-3- carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Cell Survival; Dru | 2016 |
Targeting of the Akt-nuclear factor-kappa B signaling network by [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol (OSU-A9), a novel indole-3-carbinol derivative, in a mouse model of hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; | 2009 |
Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.
Topics: Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Drug Synergism; Gene Expression Re | 2011 |
Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals.
Topics: Apoptosis; Carcinoma, Hepatocellular; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; C | 2013 |
Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol.
Topics: Alkenes; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Res | 2004 |
Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.
Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Heme Oxy | 2005 |
Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay.
Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Carcinogens; Carcinoma, Hepat | 2008 |
Fate of indole-3-carbinol in cultured human breast tumor cells.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Breast Neoplasms; Carbon Isotopes; Carcinoma, Hepa | 2002 |