indole-3-carbinol has been researched along with Cancer of Prostate in 27 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present studies, we utilized prostate cancer cell culture models to elucidate the mechanisms of action of broccoli-derived phytochemicals 3,3'-diindolylmethane (DIM) and indole-3-carbinol (I3C)." | 1.38 | Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals. ( Kim, YS; Milner, JA; Schoene, NW; Wang, TT, 2012) |
| "Mouse prostate cancer cells (TRAMP-C2, 2x10) were injected subcutaneously into three groups of C57BL/6 mice (10 mice in each group)." | 1.36 | The potential efficacy of 3,3'-diindolylmethane in prevention of prostate cancer development. ( Appel, B; Azzam, N; Fares, B; Fares, F; Stein, A, 2010) |
| "Prostate cancer is the second leading cause of cancer related deaths in men in the United States." | 1.33 | Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells. ( Chinni, SR; Li, Y; Sarkar, FH, 2005) |
| "We examined the effect of I3C on prostate cancer in a well-defined R3327 model using Copenhagen rats and the transplantable cell line, MAT-LyLu." | 1.33 | Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer. ( Ashok, BT; Chen, YG; Garikapaty, VP; Iatropoulos, M; Mittelman, A; Tiwari, RK, 2005) |
| "Since all men die with prostate cancer rather than of the disease, it is of particular interest to prevent or delay the progression of the disease by chemopreventive strategies." | 1.33 | 3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer. ( Ashok, BT; Garikapaty, VP; Mittelman, A; Tadi, K; Tiwari, RK, 2006) |
| "We previously reported that in LNCaP prostate cancer cells, I3C down-regulated cyclin-dependent kinase (CDK) 2 activity." | 1.33 | Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein. ( Bjeldanes, LF; Brew, CT; Dev, A; Firestone, GL; Hsu, JC; Wing, A, 2006) |
| "PC-3 prostate cancer cells were cultured in 96-well microtitre plates." | 1.32 | The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. ( Frydoonfar, HR; McGrath, DR; Spigelman, AD, 2003) |
| "Many anti-tumor agents against prostate cancer cells have been developed, but their unacceptable systemic toxicity to normal tissues frequently limits their usage in clinics." | 1.32 | Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP. ( Bae, I; Cho, CH; Goldberg, ID; Jeon, KI; Kim, HJ; Lee, YJ; Rih, JK; Rosen, EM, 2003) |
| "Prostate cancer is one of the most common cancers in men and it is the second leading cause of cancer related death in men in the United States." | 1.31 | Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. ( Chinni, SR; Koppolu, PK; Li, Y; Sarkar, FH; Upadhyay, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 19 (70.37) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, EK | 1 |
| Kim, YS | 2 |
| Milner, JA | 2 |
| Wang, TT | 2 |
| Fares, F | 1 |
| Azzam, N | 1 |
| Appel, B | 1 |
| Fares, B | 1 |
| Stein, A | 1 |
| Schoene, NW | 1 |
| Jeong, YM | 1 |
| Li, H | 1 |
| Kim, SY | 1 |
| Yun, HY | 1 |
| Baek, KJ | 1 |
| Kwon, NS | 1 |
| Myung, SC | 1 |
| Kim, DS | 1 |
| Wu, TY | 1 |
| Saw, CL | 1 |
| Khor, TO | 1 |
| Pung, D | 1 |
| Boyanapalli, SS | 1 |
| Kong, AN | 1 |
| Adler, S | 1 |
| Rashid, G | 1 |
| Klein, A | 1 |
| Beaver, LM | 1 |
| Yu, TW | 1 |
| Sokolowski, EI | 1 |
| Williams, DE | 1 |
| Dashwood, RH | 1 |
| Ho, E | 1 |
| Groome, NM | 1 |
| Elboray, EE | 1 |
| Inman, MW | 1 |
| Dondas, HA | 1 |
| Phillips, RM | 1 |
| Kilner, C | 1 |
| Grigg, R | 1 |
| Howells, LM | 2 |
| Gallacher-Horley, B | 1 |
| Houghton, CE | 1 |
| Manson, MM | 2 |
| Hudson, EA | 2 |
| Frydoonfar, HR | 1 |
| McGrath, DR | 1 |
| Spigelman, AD | 1 |
| Li, Y | 4 |
| Li, X | 1 |
| Sarkar, FH | 4 |
| Nachshon-Kedmi, M | 1 |
| Yannai, S | 2 |
| Haj, A | 1 |
| Fares, FA | 1 |
| Jeon, KI | 1 |
| Rih, JK | 1 |
| Kim, HJ | 1 |
| Lee, YJ | 1 |
| Cho, CH | 1 |
| Goldberg, ID | 1 |
| Rosen, EM | 2 |
| Bae, I | 1 |
| Zhang, J | 2 |
| Hsu B A, JC | 1 |
| Kinseth B A, MA | 1 |
| Bjeldanes, LF | 3 |
| Firestone, GL | 3 |
| Chinni, SR | 2 |
| Garikapaty, VP | 3 |
| Ashok, BT | 3 |
| Chen, YG | 1 |
| Mittelman, A | 3 |
| Iatropoulos, M | 1 |
| Tiwari, RK | 3 |
| Hsu, JC | 2 |
| Dev, A | 2 |
| Wing, A | 2 |
| Tadi, K | 2 |
| Fan, S | 1 |
| Meng, Q | 1 |
| Auborn, K | 1 |
| Carter, T | 1 |
| Brew, CT | 1 |
| Weng, JR | 1 |
| Tsai, CH | 1 |
| Kulp, SK | 1 |
| Wang, D | 1 |
| Lin, CH | 1 |
| Yang, HC | 1 |
| Ma, Y | 1 |
| Sargeant, A | 1 |
| Chiu, CF | 1 |
| Tsai, MH | 1 |
| Chen, CS | 1 |
| Souli, E | 1 |
| Machluf, M | 1 |
| Morgenstern, A | 1 |
| Sabo, E | 1 |
| Upadhyay, S | 1 |
| Koppolu, PK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Determine the Effect of Dietary Intervention on Novel Biomarkers of Breast Cancer Risk.[NCT00555386] | 27 participants (Actual) | Interventional | 2007-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indole-3-carbinol and Cancer of Prostate
| Article | Year |
|---|---|
Indole-3-carbinol and prostate cancer.
Topics: Apoptosis; Brassicaceae; Cell Division; Diet; G1 Phase; Gene Expression Regulation, Neoplastic; Huma | 2004 |
Indole-3-carbinol. Monograph.
Topics: Breast Neoplasms; Female; Humans; Indoles; Male; Prostatic Neoplasms; Simplexvirus; Uterine Cervical | 2005 |
25 other studies available for indole-3-carbinol and Cancer of Prostate
| Article | Year |
|---|---|
Indole-3-carbinol and 3',3'-diindolylmethane modulate androgen's effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells.
Topics: Androgens; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Adhesion; Cell Movement; Cell | 2013 |
The potential efficacy of 3,3'-diindolylmethane in prevention of prostate cancer development.
Topics: Animals; Anticarcinogenic Agents; Cell Line, Tumor; Indoles; Male; Mice; Mice, Inbred C57BL; Phospha | 2010 |
Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals.
Topics: Androgens; Anticarcinogenic Agents; Biomarkers, Tumor; Brassica; Cell Proliferation; Cyclin-Dependen | 2012 |
Indole-3-carbinol inhibits prostate cancer cell migration via degradation of beta-catenin.
Topics: Anticarcinogenic Agents; beta Catenin; Cell Movement; Epidermal Growth Factor; Humans; Indoles; Male | 2011 |
In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Cell Cycle; Dietary Supplements; Drug S | 2012 |
Indole-3-carbinol inhibits telomerase activity and gene expression in prostate cancer cell lines.
Topics: Anticarcinogenic Agents; Diethylstilbestrol; Enzyme-Linked Immunosorbent Assay; Estrogens, Non-Stero | 2011 |
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.
Topics: Androgens; Anticarcinogenic Agents; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase In | 2012 |
Carbophilic 3-component cascades: access to complex bioactive cyclopropyl diindolylmethanes.
Topics: Antineoplastic Agents; Catalysis; Cell Line; Cyclopropanes; Humans; Indoles; Male; Palladium; Prosta | 2013 |
Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line.
Topics: Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Breast; Breast Neopla | 2002 |
The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line.
Topics: Anticarcinogenic Agents; Cell Physiological Phenomena; Colorimetry; Dose-Response Relationship, Drug | 2003 |
Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis.
Topics: Cell Division; DNA, Complementary; Gene Expression Profiling; Gene Expression Regulation, Neoplastic | 2003 |
Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells.
Topics: Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Division; Cell Survival; Dose-R | 2003 |
Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP.
Topics: Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Death; Coloring Agen | 2003 |
Indole-3-carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells.
Topics: Anticarcinogenic Agents; Carcinoma; Cyclin-Dependent Kinases; Flow Cytometry; G1 Phase; Gene Express | 2003 |
Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Humans; Indoles; Male; NF-kappa B; Prostatic Neoplasms; Proto-Oncogene | 2005 |
Anti-carcinogenic and anti-metastatic properties of indole-3-carbinol in prostate cancer.
Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Indoles; Lung Neoplasms; Male; Neoplasm Tr | 2005 |
Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.
Topics: Anticarcinogenic Agents; Cell Proliferation; Chloramphenicol; Down-Regulation; Flow Cytometry; G1 Ph | 2005 |
Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells.
Topics: Antioxidants; Apoptosis; Blotting, Western; Breast Neoplasms; Chromones; Drug Combinations; Enzyme I | 2005 |
Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer.
Topics: Androgens; Anticarcinogenic Agents; Cell Cycle; Cell Death; Cell Division; Cell Line, Tumor; Diet; D | 2006 |
3,3'-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer.
Topics: Androgens; Anticarcinogenic Agents; Apoptosis; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cel | 2006 |
BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; BR | 2006 |
Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.
Topics: Anticarcinogenic Agents; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase In | 2006 |
A potent indole-3-carbinol derived antitumor agent with pleiotropic effects on multiple signaling pathways in prostate cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Dimerization; Dr | 2007 |
Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Immunohistochemistry; Indoles; Male; Mice; | 2008 |
Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
Topics: Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Cycle Proteins; Cell Division; | 2001 |