indole-3-carbinol has been researched along with Cancer of Cervix in 8 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The estrogen-sensitive MCF-7 breast cancer cell line was used for these studies." | 2.42 | Indole-3-carbinol is a negative regulator of estrogen. ( Auborn, KJ; Carter, TH; Chandraskaren, A; Chen, D; Fan, S; Goodwin, L; Rosen, EM; Williams, DE, 2003) |
| "In C33A cervical cancer cells, DIM was more potent than I3C [dose at which the number of viable cells was 50% of that in untreated cultures (LD(50)) = 50-60 micromol/L for DIM and 200 micromol/L for I3C in a mitochondrial function assay] and faster acting." | 1.31 | Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. ( Auborn, KJ; Carter, TH; Chen, DZ; Qi, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 7 (87.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carter, TH | 3 |
| Liu, K | 1 |
| Ralph, W | 1 |
| Chen, D | 2 |
| Qi, M | 3 |
| Fan, S | 2 |
| Yuan, F | 1 |
| Rosen, EM | 2 |
| Auborn, KJ | 5 |
| Stanley, M | 1 |
| Goodwin, L | 1 |
| Chandraskaren, A | 1 |
| Williams, DE | 1 |
| Jin, L | 1 |
| Chen, DZ | 2 |
| Anderson, A | 1 |
| Yang, GY | 1 |
| Arbeit, JM | 1 |
| Bell, MC | 1 |
| Crowley-Nowick, P | 1 |
| Bradlow, HL | 1 |
| Sepkovic, DW | 1 |
| Schmidt-Grimminger, D | 1 |
| Howell, P | 1 |
| Mayeaux, EJ | 1 |
| Tucker, A | 1 |
| Turbat-Herrera, EA | 1 |
| Mathis, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Single-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of 3,3'-Diindolylmethane (BR-DIM) in Patients With Systemic Lupus Erythematosus (SLE)[NCT02483624] | Phase 1 | 6 participants (Actual) | Interventional | 2016-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for indole-3-carbinol and Cancer of Cervix
| Article | Year |
|---|---|
Chapter 17: Genital human papillomavirus infections--current and prospective therapies.
Topics: Adjuvants, Immunologic; Anticarcinogenic Agents; Antiviral Agents; Anus Neoplasms; Cancer Vaccines; | 2003 |
Indole-3-carbinol is a negative regulator of estrogen.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Drug Synergism; Estrogen Antagonists; Estrogens; | 2003 |
Indole-3-carbinol. Monograph.
Topics: Breast Neoplasms; Female; Humans; Indoles; Male; Prostatic Neoplasms; Simplexvirus; Uterine Cervical | 2005 |
1 trial available for indole-3-carbinol and Cancer of Cervix
| Article | Year |
|---|---|
Placebo-controlled trial of indole-3-carbinol in the treatment of CIN.
Topics: Administration, Oral; Anticarcinogenic Agents; DNA, Viral; Dose-Response Relationship, Drug; Female; | 2000 |
4 other studies available for indole-3-carbinol and Cancer of Cervix
| Article | Year |
|---|---|
Diindolylmethane alters gene expression in human keratinocytes in vitro.
Topics: Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Proteins; Cells, Cult | 2002 |
Can indole-3-carbinol-induced changes in cervical intraepithelial neoplasia be extrapolated to other food components?
Topics: Animals; Brassica; Female; Humans; Indoles; Randomized Controlled Trials as Topic; Uterine Cervical | 2006 |
Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice.
Topics: Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Estrogen Antagonists; Female; Gen | 1999 |
Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; DNA Fragmentati | 2001 |