indole-3-carbinol has been researched along with Benign Neoplasms in 29 studies
indole-3-carbinol: occurs in edible cruciferous vegetables
indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The immediate stages in cancer development are accompanied by a fibrogenic response and the progression of the hypoxic environment is in favor of survival and proliferatory functions of cancer stem cells." | 2.61 | Molecular Targets, Anti-cancer Properties and Potency of Synthetic Indole-3-carbinol Derivatives. ( Darekordi, A; Hajizadeh, MR; Hassanshahi, G; Jafarzadeh, A; Karimabad, MN; Mahmoodi, M, 2019) |
| " However, some of these agents have poor bioavailability and many of the in-depth studies into their mechanisms of action have been carried out in vitro using doses which are unachievable in humans." | 2.44 | Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals. ( Andreadi, CK; Foreman, BE; Howells, LM; Hudson, EA; Manson, MM; Moiseeva, EP; Neal, CP; Sun, YY, 2007) |
| " For these agents, normal dietary intake, doses used in clinical trials, efficacious doses in rodents, and where available, toxic doses are compared." | 2.44 | Putative cancer chemopreventive agents of dietary origin-how safe are they? ( Gescher, AJ; Steward, WP; Verschoyle, RD, 2007) |
| "However, its anticancer mechanism has not been fully elucidated." | 1.35 | Indole-3-carbinol suppresses tumor-induced angiogenesis by inhibiting tube formation and inducing apoptosis. ( Kaji, K; Kobayashi, T; Kunimasa, K; Ohta, T; Sugiyama, S, 2008) |
| " Consequently, the picture is becoming ever more complicated, not least because results often appear to be cell-type specific, dose-response relationships are critical, and any one agent appears to have multiple mechanisms of action." | 1.33 | Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol. ( Manson, MM, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 14 (48.28) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 3 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Cheng Qian, J | 1 |
| Liu, D | 1 |
| Ping Lin, L | 1 |
| Jing Zhu, W | 1 |
| Xiang Tan, R | 1 |
| Popolo, A | 1 |
| Pinto, A | 1 |
| Daglia, M | 1 |
| Nabavi, SF | 1 |
| Farooqi, AA | 1 |
| Rastrelli, L | 1 |
| Karimabad, MN | 1 |
| Mahmoodi, M | 1 |
| Jafarzadeh, A | 1 |
| Darekordi, A | 1 |
| Hajizadeh, MR | 1 |
| Hassanshahi, G | 1 |
| Chen, X | 1 |
| Cao, X | 1 |
| Tu, X | 1 |
| Alitongbieke, G | 1 |
| Xia, Z | 1 |
| Li, X | 1 |
| Chen, Z | 1 |
| Yin, M | 1 |
| Xu, D | 2 |
| Guo, S | 1 |
| Li, Z | 1 |
| Chen, L | 1 |
| Zhang, X | 1 |
| Gao, M | 1 |
| Liu, J | 1 |
| Zeng, Z | 1 |
| Zhou, H | 1 |
| Su, Y | 1 |
| Zhang, XK | 1 |
| Lee, YR | 1 |
| Chen, M | 1 |
| Lee, JD | 1 |
| Zhang, J | 1 |
| Lin, SY | 1 |
| Fu, TM | 1 |
| Chen, H | 1 |
| Ishikawa, T | 1 |
| Chiang, SY | 1 |
| Katon, J | 1 |
| Zhang, Y | 2 |
| Shulga, YV | 1 |
| Bester, AC | 1 |
| Fung, J | 1 |
| Monteleone, E | 1 |
| Wan, L | 1 |
| Shen, C | 1 |
| Hsu, CH | 1 |
| Papa, A | 1 |
| Clohessy, JG | 1 |
| Teruya-Feldstein, J | 1 |
| Jain, S | 1 |
| Wu, H | 1 |
| Matesic, L | 1 |
| Chen, RH | 1 |
| Wei, W | 1 |
| Pandolfi, PP | 1 |
| Benninghoff, AD | 1 |
| Williams, DE | 1 |
| Khan, M | 1 |
| Maryam, A | 1 |
| Mehmood, T | 1 |
| Ma, T | 1 |
| Fujioka, N | 1 |
| Fritz, V | 1 |
| Upadhyaya, P | 1 |
| Kassie, F | 1 |
| Hecht, SS | 1 |
| Kunimasa, K | 1 |
| Kobayashi, T | 1 |
| Sugiyama, S | 1 |
| Kaji, K | 1 |
| Ohta, T | 1 |
| Sarkar, FH | 2 |
| Wang, Z | 1 |
| Kong, D | 1 |
| Moiseeva, EP | 3 |
| Manson, MM | 5 |
| Ahmad, A | 1 |
| Sakr, WA | 1 |
| Rahman, KM | 1 |
| Weng, JR | 2 |
| Omar, HA | 1 |
| Kulp, SK | 2 |
| Chen, CS | 2 |
| Kim, YS | 1 |
| Milner, JA | 1 |
| Aggarwal, BB | 1 |
| Ichikawa, H | 1 |
| Minich, DM | 1 |
| Bland, JS | 1 |
| Howells, LM | 1 |
| Neal, CP | 1 |
| Foreman, BE | 1 |
| Andreadi, CK | 1 |
| Sun, YY | 1 |
| Hudson, EA | 2 |
| Verschoyle, RD | 1 |
| Steward, WP | 1 |
| Gescher, AJ | 1 |
| Almeida, GM | 1 |
| Jones, GD | 1 |
| Tsai, CH | 1 |
| Rosenkranz, HS | 1 |
| Bradlow, HL | 2 |
| Sepkovic, DW | 2 |
| Telang, NT | 2 |
| Osborne, MP | 2 |
| Gescher, A | 1 |
| Plummer, SM | 1 |
| Squires, MS | 1 |
| Prigent, SA | 1 |
| Stoner, G | 1 |
| Casto, B | 1 |
| Ralston, S | 1 |
| Roebuck, B | 1 |
| Pereira, C | 1 |
| Bailey, G | 1 |
| Ames, BN | 1 |
| Gold, LS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-Blinded, Placebo-Controlled Study With Immunotype Specific Dietary Supplements to Improve Inflammatory Age® by Edifice Health[NCT04983017] | 750 participants (Anticipated) | Interventional | 2021-08-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 reviews available for indole-3-carbinol and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor.
Topics: Apoptosis; Brassicaceae; Cell Proliferation; Gene Expression Regulation, Neoplastic; Genomic Instabi | 2017 |
Molecular Targets, Anti-cancer Properties and Potency of Synthetic Indole-3-carbinol Derivatives.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Humans; Indoles; Molecular Targeted Therapy; | 2019 |
Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals.
Topics: Abietanes; Alkaloids; Allyl Compounds; Animals; Antineoplastic Agents; ATP Binding Cassette Transpor | 2015 |
Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Biomarkers; Brassicaceae; Carcinogens; Cell Line, | 2016 |
Cellular signaling perturbation by natural products.
Topics: Antineoplastic Agents; Carotenoids; Catechin; Curcumin; Humans; Indoles; Isoflavones; Lycopene; Neop | 2009 |
Dietary chemopreventive phytochemicals: too little or too much?
Topics: Animals; Catechin; Cell Transformation, Neoplastic; Curcumin; Diet; Food; Fruit; Genistein; Humans; | 2009 |
Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics.
Topics: Animals; Antineoplastic Agents; Biological Products; Curcumin; Humans; Indoles; Isoflavones; Neoplas | 2009 |
Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Humans; Indoles; Neoplasms | 2010 |
Pharmacological exploitation of indole-3-carbinol to develop potent antitumor agents.
Topics: Antineoplastic Agents; Cyclin-Dependent Kinase 6; Humans; Indoles; Neoplasms; NF-kappa B; Proto-Onco | 2010 |
Targets for indole-3-carbinol in cancer prevention.
Topics: Anticarcinogenic Agents; Apoptosis; Brassicaceae; Cell Cycle; Cytochrome P-450 CYP1A1; DNA Repair; G | 2005 |
Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2005 |
A review of the clinical efficacy and safety of cruciferous vegetable phytochemicals.
Topics: Anticarcinogenic Agents; Brassicaceae; Consumer Product Safety; Humans; Indoles; Neoplasms; Phytoest | 2007 |
Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Catechin | 2007 |
Putative cancer chemopreventive agents of dietary origin-how safe are they?
Topics: Antineoplastic Agents, Phytogenic; Capsaicin; Catechin; Chemoprevention; Consumer Product Safety; Cu | 2007 |
Indole-3-carbinol as a chemopreventive and anti-cancer agent.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Drug Design; Drug Resistanc | 2008 |
Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Estrogen Antagonists; Female; Humans; Indoles; Neoplasms; | 1999 |
Blocking and suppressing mechanisms of chemoprevention by dietary constituents.
Topics: Anticarcinogenic Agents; Apoptosis; Arachidonic Acid; Cell Cycle; Curcumin; Diet; Enzyme Inhibitors; | 2000 |
Phytochemicals as modulators of cancer risk.
Topics: Anticarcinogenic Agents; Catechin; Estrogens, Non-Steroidal; Female; Humans; Indoles; Isoflavones; I | 1999 |
10 other studies available for indole-3-carbinol and Benign Neoplasms
| Article | Year |
|---|---|
Minor bioactive indoles from kimchi mirror the regioselectivity in indole-3-carbinol oligomerization.
Topics: Brassicaceae; Fermented Foods; Humans; Indoles; Neoplasms | 2022 |
BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway.
Topics: Animals; Apoptosis; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Hydrocarbons, Fluo | 2019 |
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
Topics: Anticarcinogenic Agents; Carcinogenesis; HEK293 Cells; Humans; Indoles; Male; Neoplasms; Protein Mul | 2019 |
The role of estrogen receptor β in transplacental cancer prevention by indole-3-carbinol.
Topics: Animals; Anticarcinogenic Agents; Benzopyrenes; Carcinogens; Chemoprevention; Drug Evaluation, Precl | 2013 |
Indole-3-carbinol suppresses tumor-induced angiogenesis by inhibiting tube formation and inducing apoptosis.
Topics: Air Sacs; Animals; Apoptosis; Caspases; Cells, Cultured; Enzyme Activation; Indoles; Mice; Neoplasms | 2008 |
Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol.
Topics: Apoptosis; Catechin; Cell Cycle; Curcumin; Flavonoids; Humans; Indoles; Mitogen-Activated Protein Ki | 2005 |
Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Catechin; Cell Cycle; Cell Line, Tu | 2007 |
From mutagen hunter to genome defender, a change in paradigm.
Topics: Animals; Genetics; Genome; History, 20th Century; Humans; Indoles; Mutagens; Neoplasms; Structure-Ac | 1999 |
Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Azoxymethane; Body | 2002 |
Natural chemicals, synthetic chemicals, risk assessment, and cancer.
Topics: Antioxidants; DNA; DNA Damage; Environmental Exposure; Ethanol; Food; Humans; Indoles; Neoplasms; Pe | 1990 |