indium-oxine and Venous-Thrombosis

Clinical assessment of platelet scintigraphy by using autologous platelet labeled with 111-indium oxine to detect thrombotic activity for deep vein thrombosis. Platelet accumulation on scintigrams had a tendency to correlate with aggravation of acute thrombotic symptoms in deep vein thrombosis. This method was a useful procedure to make early diagnosis of deep vein thrombosis by detecting of abnormal accumulation of platelet. In addition, appropriate thrombolytic and anticoagulant therapy resulted in reduced platelet accumulation in conjunction with improvement of acute clinical symptoms. Thus, platelet scintigraphy could be available to evaluate thrombotic activity and might be useful for determining the optimal indications of thrombolytic and anticoagulation therapies for acute deep vein thrombosis. On the other hand, another kind of scintigraphy might be inevitable especially for detection of the pulmonary embolism. Anticoagulation therapy is also effective for pulmonary embolism.

Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Blood Platelets; Female; Humans; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Platelet Aggregation; Predictive Value of Tests; Pulmonary Embolism; Radionuclide Imaging; Thrombolytic Therapy; Venous Thrombosis

The authors reviewed the clinical value of platelet scintigraphy by using autologous platelets labeled with indium-111-oxine to detect thrombotic activity at vascular thrombosis sites. Thirty-nine patients with deep vein thrombosis, 28 with arteriosclerosis obliterans, and 10 with pulmonary embolism were the subjects of this study. Platelet accumulation on scintigrams had a tendency to correlate with aggravation of acute thrombotic symptoms in deep vein thrombosis and arteriosclerosis obliterans. In addition, appropriate thrombolytic and anticoagulant therapy resulted in reduced platelet accumulation in conjunction with improvement of acute symptoms. On the other hand, this type of scintigraphy was not so sensitive for assessment of pulmonary embolism. Platelet scintigraphy could facilitate the assessment of thrombotic activity and might be useful for determining the optimal indication of thrombolytic and anticoagulant therapy for acute vascular thrombosis.

Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Arteriosclerosis Obliterans; Aspirin; Blood Platelets; Epoprostenol; Female; Fibrinolytic Agents; Humans; Indium Radioisotopes; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Platelet Aggregation Inhibitors; Pulmonary Embolism; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Aggregated Albumin; Vasodilator Agents; Venous Thrombosis; Warfarin