indium-oxine and Peripheral-Vascular-Diseases

Platelet half-life was assessed with autologous 111In-marked platelets in fourteen subjects, four women and ten men, who previously had suffered vascular accidents (myocardial infarction, TIA, stroke or peripheral obstructive arterial disease). Results, compared to findings in low risk subjects showed a statistically significant correlation of platelet half-life to certain pathologies (TIA, stroke) as well as to habits (tobacco, alcohol) and biological variables (age, sex). By and large, data were analogous to those of the current scientific literature in so far as certain factors shorten platelet half-life. A correlation was also found between platelet half-life and time elapsed since the pathological event. Liver sequestration evaluated by total body scintigraphy showed high levels in one case each with a history of stroke, a history of TIA, and a history of peripheral arterial disease, and splenic sequestration in only one case with a history of stroke.

Topics: Adult; Aged; Blood Platelets; Cell Survival; Cerebrovascular Disorders; Coronary Disease; Female; Humans; Indium Radioisotopes; Ischemia; Ischemic Attack, Transient; Male; Middle Aged; Models, Biological; Organometallic Compounds; Oxyquinoline; Peripheral Vascular Diseases