indium-oxine and Lung-Neoplasms

Few studies have examined tumor cell distribution following laparoscopic surgery for colorectal cancer. We examined the effect of carbon dioxide pneumoperitoneum on the distribution of intrasplenically injected colon cancer cells in mice.. Mice were intrasplenically injected with 2 x 10(4) colon 26 cells labeled with 111In-oxine and were randomized to undergo pneumoperitoneum at 10 mmHg for 30 min or to receive no treatment other than anesthesia. Radioactivity of the liver, lungs, and spleen was measured 30, 60, 90, or 150 min following tumor inoculation.. The dynamic changes in the hepatic radioactivity were not similar between groups. However, the values were not significantly different at any time point. The radioactivity of lungs was extremely low in both groups throughout the experimental period.. Pneumoperitoneum does not appear to cause the accumulation of intraportally spreading tumor cells in the liver, but it may affect the dynamic changes of tumor cells. Also, tumor cell localization in the lungs is negligible in both pneumoperitoneum and control groups.

Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Colonic Neoplasms; Indium Radioisotopes; Injections; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Seeding; Neoplasm Transplantation; Organometallic Compounds; Oxyquinoline; Pneumoperitoneum, Artificial; Portal System; Radionuclide Imaging; Radiopharmaceuticals; Random Allocation; Spleen; Tissue Distribution

Photodynamic therapy is being investigated as an adjuvant treatment for intracranial neoplasms. The efficacy of this therapy is based on the uptake of photosensitizer by neoplastic tissue, its clearance from surrounding brain tissue, and the timing and placement of photoactivating sources. Photofrin-II is the photosensitizer most actively being investigated. We labeled Photofrin-II with Indium-111 and studied the uptake and distribution of this agent in 20 patients with intracranial neoplasms, using single photon emission computed tomography (SPECT) with volume rendering in three dimensions. Of these patients, 16 had malignant glial tumors, 2 had metastatic deposits, 1 had a chordoma, and 1 had a meningioma. Anatomical-spatial data correlated well between the SPECT images and contrast-enhanced computed tomography or magnetic resonance images. Regions of focal uptake on SPECT images correlated with the surgical histopathological findings of the neoplasm. The kinetics of photosensitizer uptake varied according to the tumor's histological findings, the patient's use of steroids, and among patients with similar types of tumor histology. Peak ratios of target-to-nontarget tissue varied from 24 to 72 hours after injection. The study data show that, to be most effective, photodynamic therapy may need to be tailored for each patient by correlating SPECT images with anatomical data produced by computed tomography or magnetic resonance images. Photoactivating sources then can be placed, using computer-assisted stereotactics, to activate a prescribed volume of photosensitized tumor at the optimal time for treatment.

Topics: Adult; Aged; Astrocytoma; Brain; Brain Neoplasms; Dihematoporphyrin Ether; Female; Glioblastoma; Glioma; Hematoporphyrin Photoradiation; Humans; Lung Neoplasms; Male; Meningioma; Metabolic Clearance Rate; Middle Aged; Neoplasm Recurrence, Local; Organometallic Compounds; Oxyquinoline; Tomography, Emission-Computed, Single-Photon

Topics: Bone Neoplasms; Female; Humans; Hydroxyquinolines; Indium; Leukocytes; Lung Neoplasms; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging