indium-oxine and Endocarditis

A 54-y old women with earlier replacement of the mitral and aortic valves and clinical signs of localized endocarditis was studied with 99mTc-labelled anti NCA-95 antibody. Whereas echocardiographic findings were negative, increased radionuclide uptake was observed left parasternal over the mitral valve as a sign of prosthetic valve endocarditis. This result could be confirmed by a similar study with leukocytes labelled in vitro with 111In-oxine.

Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Cell Adhesion Molecules; Endocarditis; Female; Heart Valve Prosthesis; Humans; Indium Radioisotopes; Leukocytes; Membrane Glycoproteins; Middle Aged; Mitral Valve; Organometallic Compounds; Organotechnetium Compounds; Oximes; Oxyquinoline; Radionuclide Imaging; Technetium Tc 99m Exametazime