indium-oxine and Coronary-Thrombosis

111In-oxine-labelled platelet heart scintigraphy (In-plt) was used to evaluate the activity of left atrial thrombi detected by transoesophageal echocardiography (TEE) in 16 cases of rheumatic heart disease. The effect of anticoagulants on the therapeutic intervention of these patients was evaluated by In-plt and TEE. In-plt was performed in all patients in serial pre- and post-anticoagulant therapy studies with anterior, 45 degrees left anterior oblique and left lateral views taken daily from the second to sixth day after injection of labelled platelets. After discontinuing anticoagulants for at least 1 week, only nine cases of left atrial thrombi were detected among the 16 cases by initial In-plt. After anticoagulants were again used for at least 3 weeks, all nine positive cases became negative on repeat In-plt. These results suggest that the diagnostic sensitivity of In-plt is lower than that of TEE. However, In-plt is more suitable and useful for evaluating the activity of left atrial thrombi after antithrombotic agent therapy and for monitoring the effect of anticoagulant therapy on left atrial thrombi in patients with rheumatic heart disease.

Topics: Adult; Aged; Anticoagulants; Atrial Function, Left; Blood Platelets; Coronary Thrombosis; Echocardiography, Transesophageal; Female; Heart Atria; Humans; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging; Radiopharmaceuticals; Rheumatic Heart Disease

Topics: Blood Platelets; Coronary Thrombosis; Humans; Male; Myocardial Infarction; Organometallic Compounds; Oxyquinoline; Radiography; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon; Treatment Outcome

Intracardiac thrombi can be localized and quantified by indium-111-labelling of thrombocytes with a high sensitivity and specificity. The scintigraphic procedure has a complementary evidence to echocardiography. Scintigraphy shows activity and age of thrombosis, whereas echocardiography seems to be superior in determination of mass and localization. In older thrombi scintigraphy fails because of organisation and endothelialization of the thrombus surface. For the reason of determination of the age of an intraventricular thrombus this method might have an increasing acceptance.

Topics: Aged; Blood Platelets; Coronary Disease; Coronary Thrombosis; Humans; Indium Radioisotopes; Male; Myocardial Infarction; Organometallic Compounds; Oxyquinoline; Prognosis; Radionuclide Imaging

Intracardiac thrombi can be localized and quantified by Indium-111-labelling of thrombocytes with a high sensitivity and specificity. The scintigraphic procedure has a complementary evidence to echocardiography. Scintigraphy shows activity and age of thrombosis, whereas echocardiography seems to be superior in determination of mass and localization. In older thrombi scintigraphy fails because of organisation and endothelialization of the thrombus surface. For the reason of determination of the age of an intraventricular thrombus this method might have an increasing acceptance.

Topics: Aged; Blood Platelets; Coronary Disease; Coronary Thrombosis; Heart Ventricles; Humans; Hydroxyquinolines; Indium Radioisotopes; Male; Myocardial Infarction; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging; Recurrence