indium-oxine and Cerebrovascular-Disorders

Radiolabeled blood cells are widely used for both clinical and research studies. In vitro and in vivo studies have shown the tagging process does not significantly affect function. The labeling techniques and clinical uses of labeled leukocytes and platelets are reviewed.

Topics: Abscess; Blood Platelets; Cerebrovascular Disorders; Chromium Radioisotopes; Eosinophils; Fever of Unknown Origin; Graft Rejection; Humans; Hydroxyquinolines; Indium; Isotope Labeling; Leukocyte Count; Leukocytes; Lymphocytes; Organometallic Compounds; Oxyquinoline; Pulmonary Embolism; Radioisotopes; Radionuclide Imaging; Thrombophlebitis; Tropolone

Topics: Aged; Aortic Aneurysm; Blood Platelets; Blood Vessel Prosthesis; Cell Survival; Cerebrovascular Disorders; Heart Diseases; Humans; Indium; Ischemic Attack, Transient; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Pulmonary Embolism; Radioisotopes; Radionuclide Imaging; Thrombocytopenia; Thromboembolism; Thrombophlebitis; Time Factors

Platelet half-life was assessed with autologous 111In-marked platelets in fourteen subjects, four women and ten men, who previously had suffered vascular accidents (myocardial infarction, TIA, stroke or peripheral obstructive arterial disease). Results, compared to findings in low risk subjects showed a statistically significant correlation of platelet half-life to certain pathologies (TIA, stroke) as well as to habits (tobacco, alcohol) and biological variables (age, sex). By and large, data were analogous to those of the current scientific literature in so far as certain factors shorten platelet half-life. A correlation was also found between platelet half-life and time elapsed since the pathological event. Liver sequestration evaluated by total body scintigraphy showed high levels in one case each with a history of stroke, a history of TIA, and a history of peripheral arterial disease, and splenic sequestration in only one case with a history of stroke.

Topics: Adult; Aged; Blood Platelets; Cell Survival; Cerebrovascular Disorders; Coronary Disease; Female; Humans; Indium Radioisotopes; Ischemia; Ischemic Attack, Transient; Male; Middle Aged; Models, Biological; Organometallic Compounds; Oxyquinoline; Peripheral Vascular Diseases

Topics: Aged; Blood Platelets; Carotid Arteries; Carotid Artery Diseases; Cerebrovascular Disorders; Female; Humans; Indium Radioisotopes; Intracranial Embolism and Thrombosis; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging

In the present study the prevalence of active atherosclerotic lesion sites in the carotid and femoral arteries as well as the platelet survival in a selected group of 33 patients (8 males, 25 females) below the age of 50 after juvenile stroke has been examined. In the patients studied a high frequency (80%) of positive (visible) carotid artery lesions with a platelet uptake ratio (PUR) ranging from 1.07-1.79 as well as an extremely shortened platelet survival were monitored. In-vitro platelet function tests, however, did not show significant abnormalities. No correlation between PUR, platelet survival, platelet function and the clinical situation could be assessed. These findings indicate that in this highly selected group of patients in-vivo haemostatic balancing seems to be severely impaired.

Topics: Adult; Arteriosclerosis; Aspirin; Blood Platelets; Carotid Arteries; Carotid Artery Diseases; Cell Survival; Cerebral Arteries; Cerebrovascular Disorders; Female; Hemostasis; Humans; Indium Radioisotopes; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Platelet Function Tests; Radionuclide Imaging; Risk Factors

Platelet scintigraphy was performed on 62 patients with cerebral ischaemia. Pathological scintigraphic images were obtained in 29 of the 62 patients. In 79.3% of these 29 patients the scan was abnormal in the vessel clinically affected. Platelet scintigraphy was abnormal in 21 of 34 patients with normal angiogram or only slight atherosclerosis. In patients undergoing antiplatelet therapy, platelet scintigraphy was less often positive than in untreated patients. It is suggested that platelet scintigraphy could be an appropriate technique for detecting small mural thrombi of the carotid artery, which are the source of arterio-arterial emboli, and for controlling the efficiency of antiplatelet therapy.

Topics: Adult; Aged; Blood Platelets; Cerebral Angiography; Cerebrovascular Disorders; Female; Humans; Hydroxyquinolines; Indium; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Platelet Aggregation; Radioisotopes; Radionuclide Imaging