indium-oxine and Carotid-Artery-Diseases

Topics: Aged; Blood Platelets; Carotid Arteries; Carotid Artery Diseases; Cerebrovascular Disorders; Female; Humans; Indium Radioisotopes; Intracranial Embolism and Thrombosis; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging

In the present study the prevalence of active atherosclerotic lesion sites in the carotid and femoral arteries as well as the platelet survival in a selected group of 33 patients (8 males, 25 females) below the age of 50 after juvenile stroke has been examined. In the patients studied a high frequency (80%) of positive (visible) carotid artery lesions with a platelet uptake ratio (PUR) ranging from 1.07-1.79 as well as an extremely shortened platelet survival were monitored. In-vitro platelet function tests, however, did not show significant abnormalities. No correlation between PUR, platelet survival, platelet function and the clinical situation could be assessed. These findings indicate that in this highly selected group of patients in-vivo haemostatic balancing seems to be severely impaired.

Topics: Adult; Arteriosclerosis; Aspirin; Blood Platelets; Carotid Arteries; Carotid Artery Diseases; Cell Survival; Cerebral Arteries; Cerebrovascular Disorders; Female; Hemostasis; Humans; Indium Radioisotopes; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Platelet Function Tests; Radionuclide Imaging; Risk Factors

Scintigraphy with 111indium-marked autologous platelets has been used during percutaneous transluminal dilatation of supra-aortic arterial stenoses; there were 14 successful dilatations and one attempted dilatation. The material consisted of nine stenoses of the internal carotid artery, two stenoses at the origin of the vertebral artery and four stenoses of the first part of the left subclavian artery. Deposition of thrombi could be demonstrated by scintigraphy, both before and after catheter dilatation. The value of this method for deciding on the type of treatment and for observing the course of percutaneous dilatation of cerebral vessels is discussed.

Topics: Angioplasty, Balloon; Arterial Occlusive Diseases; Blood Platelets; Carotid Artery Diseases; Humans; Indium; Methods; Organometallic Compounds; Oxyquinoline; Radioisotopes; Radionuclide Imaging; Subclavian Artery; Vertebral Artery

Topics: Aneurysm; Blood Platelets; Carotid Artery Diseases; Carotid Artery, Internal; Cerebral Angiography; Female; Humans; Indium; Middle Aged; Organometallic Compounds; Oxyquinoline; Radioisotopes; Radionuclide Imaging; Tomography, X-Ray Computed

A new dual isotope scintigraphic (DISC) examination of the carotid arteries consisting of simultaneous injections of 111In-labeled platelets and 99mTc-labeled red cells was performed on eight male patients suffering from amaurosis fugax attacks. In concordance with the angiographically proven high percentage of significant extracranial carotid disease in patients with amaurosis fugax, six of the eight patients examined had an increased platelet accumulation in the carotid artery clinically affected. In one patient with normal angiography and one amaurosis fugax attack the platelet scintigraphy even revealed a pathological platelet accumulation in the ipsilateral carotid artery. These findings confirm the hypothesis that most amaurosis fugax attacks are due to arterio-arterial emboli originating from atherosclerotic plaques of the carotid bifurcation.

Topics: Aged; Arteriosclerosis; Blindness; Carotid Artery Diseases; Carotid Artery Thrombosis; Carotid Artery, External; Carotid Artery, Internal; Cerebral Angiography; Constriction, Pathologic; Humans; Indium; Ischemic Attack, Transient; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging; Serum Albumin; Technetium Tc 99m Aggregated Albumin; Tin; Tin Compounds