indium-oxine and Cardiovascular-Diseases

There were many studies for diagnosis of localization and activity of thrombi and inflammation using indium-111-oxine labeled platelet (In-plt) and leucocyte scintigraphy (In-WBC), respectively. The study using these techniques is decreasing recently, because other diagnostic modarities have been developed and the techniques of these scintigraphy are complicated. However, because these scintigraphy are noninvasive, it is expected that these are widely applied to the clinical diagnosis and follow up. 1. Platelet scintigraphy can visualized thrombi and distinguish the activation of platelet aggregation. There were many reports and reviews. I reviewed recent studies in cardiovascular diseases and our cases. 2. Leucocyte scintigraphy (In-WBC) is usually used for the detection of inflammation. Furthermore, it is possible that In-WBC can detect inflammation of the arteriosclerotic lesion of the aortic wall. I introduced our studies of In-WBC in aortic aneurysma and aortic dissection. The In-WBC maybe useful for detection of inflammation of the aortic aneurysma and evaluation of prognosis of aortic dissection.

Topics: Aortic Aneurysm; Aortic Dissection; Blood Platelets; Cardiovascular Diseases; Humans; Inflammation; Leukocytes; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging; Radiopharmaceuticals; Thrombosis

Topics: Adult; Aged; Alprostadil; Blood Platelets; Cardiovascular Diseases; Cyclic GMP; Drug Synergism; Drug Therapy, Combination; Female; Humans; Indium Radioisotopes; Isosorbide Dinitrate; Male; Middle Aged; Nitric Oxide; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging; Random Allocation; Thrombosis