indium-oxine and Adenocarcinoma

Few studies have examined tumor cell distribution following laparoscopic surgery for colorectal cancer. We examined the effect of carbon dioxide pneumoperitoneum on the distribution of intrasplenically injected colon cancer cells in mice.. Mice were intrasplenically injected with 2 x 10(4) colon 26 cells labeled with 111In-oxine and were randomized to undergo pneumoperitoneum at 10 mmHg for 30 min or to receive no treatment other than anesthesia. Radioactivity of the liver, lungs, and spleen was measured 30, 60, 90, or 150 min following tumor inoculation.. The dynamic changes in the hepatic radioactivity were not similar between groups. However, the values were not significantly different at any time point. The radioactivity of lungs was extremely low in both groups throughout the experimental period.. Pneumoperitoneum does not appear to cause the accumulation of intraportally spreading tumor cells in the liver, but it may affect the dynamic changes of tumor cells. Also, tumor cell localization in the lungs is negligible in both pneumoperitoneum and control groups.

Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Colonic Neoplasms; Indium Radioisotopes; Injections; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Seeding; Neoplasm Transplantation; Organometallic Compounds; Oxyquinoline; Pneumoperitoneum, Artificial; Portal System; Radionuclide Imaging; Radiopharmaceuticals; Random Allocation; Spleen; Tissue Distribution

In three patients with fever of unknown etiology, an Indium-111-Oxine WBC (White blood cell) scan was performed, in order to detect occult sites of inflammation. An intra-abdominal abscess was located in two cases, while in the third the negative result of the scan directed the diagnosis to other systemic pathologies.

Topics: Abscess; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Connective Tissue Diseases; Female; Fever of Unknown Origin; Humans; Hydroxyquinolines; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Radionuclide Imaging; Rectal Diseases

The use of In-111 labeled leukocytes for abscess localization is becoming well established. The first report of In-111 imaging following hepatic embolization is presented. A 45-year-old man with adenocarcinoma of the colon and metastatic liver disease was treated for intractable pain using particulate embolization of the hepatic artery. In-111 leukocyte imaging was performed to rule out abscess formation. The distribution of the labeled leukocytes demonstrated hepatic uptake commensurate with Tc-99m sulfur colloid (SC) images. Areas of embolization did not accumulate tracer. Pathologic examination at autopsy correlated with the distribution of the labeled leukocytes. Thus, therapeutic embolization did not alter the normal distribution of this tracer in functional hepatic tissue.

Topics: Adenocarcinoma; Colonic Neoplasms; Embolization, Therapeutic; Hepatic Artery; Humans; Hydroxyquinolines; Indium; Leukocytes; Liver Abscess; Liver Neoplasms; Male; Middle Aged; Organometallic Compounds; Oxyquinoline; Pain, Intractable; Radioisotopes; Radionuclide Imaging

A 61-year-old white female with ulcerative carcinoma of the sigmoid exhibited an abscess-like pattern on a white blood cell scan using 111In-oxine-labeled 'pure' granulocytes. Constant 111In activity could be seen in the tumor 0.5, 3, and 20 h after the reinjection of the labeled cells. The absence of an abscess was proven by surgery and histological investigation.

Topics: Abdomen; Abscess; Adenocarcinoma; Diagnosis, Differential; Female; Granulocytes; Humans; Hydroxyquinolines; Indium; Middle Aged; Organometallic Compounds; Oxyquinoline; Radioisotopes; Radionuclide Imaging; Sigmoid Neoplasms; Time Factors