indirubin-3'-monoxime has been researched along with Acute Confusional Senile Dementia in 3 studies
indirubin-3'-monoxime: has antiangiogenic activity
indirubin-3'-monoxime : A member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indirubins were recently described as potent (IC(50): 50-100 nm) inhibitors of cyclin-dependent kinases (CDKs)." | 1.31 | Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? ( Bibb, JA; Biernat, J; Eisenbrand, G; Garnier, M; Greengard, P; Hoessel, R; Leclerc, S; Mandelkow, EM; Marko, D; Meijer, L; Snyder, GL; Wu, YZ, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Leclerc, S | 1 |
| Garnier, M | 1 |
| Hoessel, R | 1 |
| Marko, D | 1 |
| Bibb, JA | 1 |
| Snyder, GL | 1 |
| Greengard, P | 1 |
| Biernat, J | 1 |
| Wu, YZ | 1 |
| Mandelkow, EM | 1 |
| Eisenbrand, G | 1 |
| Meijer, L | 1 |
| Choudhary, BS | 1 |
| Mehta, P | 1 |
| Bach, S | 1 |
| Ruchaud, S | 1 |
| Robert, T | 1 |
| Josselin, B | 1 |
| Filipek, S | 1 |
| Malik, R | 1 |
| Ding, Y | 1 |
| Qiao, A | 1 |
| Fan, GH | 1 |
3 other studies available for indirubin-3'-monoxime and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Topics: Adenosine Triphosphate; Alkaloids; Alzheimer Disease; Animals; Antibiotics, Antineoplastic; Calcium- | 2001 |
Discovery of thiazolidin-4-one analogue as selective GSK-3β inhibitor through structure based virtual screening.
Topics: Alzheimer Disease; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; G | 2021 |
Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2010 |