indinavir-sulfate and Uveitis--Anterior

Uveitis is an ocular manifestation rarely observed in HIV-infected patients. We observed three cases of anterior uveitis without progressive retinitis in HIV patients receiving antiprotease treatment.. The first patient developed a first episode of uveitis during ritonavir therapy. Two other episodes occurred with indinavir. The second patient developed uveitis when treated with indinavir. In the third patient, the first episode developed with indinavir and a second with a ritonavir-saquinavir combination. Uveitis was unilateral in 4 episodes. Clinical manifestations were red irritable eyes and, in 2 episodes, reduced visual acuity. The antiprotease was interrupted in 4 of the 6 episodes and clinical course was rapidly favorable.. Pure anterior uveitis should suggest drug induction in HIV infected patients; rifabutin is often the cause. Infectious causes predominate in case of total uveitis associating choroid and retinal involvement. Cytomegalovirus, herpes zoster, syphilis, and toxoplasmosis have been incriminated. Antiproteases would appear to be a new cause of anterior uveitis in HIV-infected patients.

Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Drug Combinations; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Middle Aged; Rifabutin; Ritonavir; Saquinavir; Uveitis; Uveitis, Anterior; Visual Acuity

Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; HIV Protease Inhibitors; Humans; Indinavir; Male; Uveitis, Anterior