indinavir-sulfate and Skin-Neoplasms

Lymphomas are a well-known malignancy in individuals with human immunodeficiency virus type 1 (HIV-1) infection. Most lymphomas are of B-cell lineage and cutaneous involvement is rare. Cutaneous T-cell lymphomas have been previously described in adults with HIV-1 infection but are exceptional in HIV-1 infected-children. The authors report here the extremely rare case of a large-cell cutaneous lymphoproliferation of T-cell lineage expressing Epstein-Barr virus (EBV) antigens in a 15-year-old boy with AIDS and his uncommon clinical presentation. The atypical clinical evolution with a nonaggressive treatment emphasizes that for immunosuppressed patients, the diagnosis of immunosuppression-related lymphoproliferative disorder should be considered before giving the diagnosis of malignant lymphoma when tumoral lymphoid cells express EBV antigens.

Topics: Acquired Immunodeficiency Syndrome; Adolescent; Anti-HIV Agents; Antigens, CD; Antiretroviral Therapy, Highly Active; Combined Modality Therapy; Diagnosis, Differential; Epstein-Barr Virus Infections; Gene Rearrangement, T-Lymphocyte; Herpesvirus 4, Human; HIV Protease Inhibitors; Humans; Immunophenotyping; Indinavir; Lamivudine; Lymphoma, AIDS-Related; Lymphoma, T-Cell, Cutaneous; Male; Reverse Transcriptase Inhibitors; RNA, Viral; Sarcoma, Kaposi; Skin Neoplasms; Stavudine; Transfusion Reaction; Viral Matrix Proteins