indinavir-sulfate and Nails--Ingrown

Many persons with haemophilia suffer from HIV and receive highly active antiretroviral therapy. Three patients received indinavir and required surgery due to ingrown toenails. Two patients suffered from a traumatic subungual haematoma. The treatment protocol is described whereby the pressure exerted onto the germinal layer and the nail bed is relieved in order to alleviate pain and nail matrix damage.

Topics: Adult; Granuloma, Pyogenic; Hematoma; Hemophilia A; Hemophilia B; HIV Protease Inhibitors; Humans; Indinavir; Middle Aged; Nail Diseases; Nails; Nails, Ingrown; Substance-Related Disorders

Topics: Adolescent; Adult; Cheilitis; Female; HIV Infections; Humans; Indinavir; Male; Middle Aged; Nails, Ingrown; Paronychia; Protease Inhibitors; Skin Diseases; Time Factors

Lamivudine and indinavir are two medications used to treat human immunodeficiency virus (HIV) that have recently been reported to cause paronychia. The nails of the great toes are commonly affected. This is the second report of paronychia and ingrown toenails due to indinavir and the first report of recurrent paronychia and ingrown toenails associated with this drug.

Topics: Adult; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Male; Nails, Ingrown; Paronychia; Recurrence; Toes

Topics: Adult; Aged; Anti-HIV Agents; Case-Control Studies; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Middle Aged; Nails, Ingrown; Reverse Transcriptase Inhibitors

A French study confirms recent reports of hair loss in men as a side effect of the protease inhibitor Crixivan (Indinavir). All ten men in the study experienced various types of hair loss, which grew back several months after switching to another protease inhibitor or NNRTI. Ingrown toenails are another side effect recorded by a different French study, corroborating reports from patients taking Crixivan. Patients on Crixivan, experiencing these symptoms, should discuss them with their doctor.

Topics: Alopecia; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Nails, Ingrown; Toes

Topics: Adult; AIDS-Related Opportunistic Infections; Female; Granuloma, Pyogenic; Hallux; HIV Protease Inhibitors; Humans; Indinavir; Male; Middle Aged; Nails, Ingrown; Paronychia