indinavir-sulfate and Leishmaniasis--Cutaneous

indinavir-sulfate has been researched along with Leishmaniasis--Cutaneous* in 2 studies

Other Studies

2 other study(ies) available for indinavir-sulfate and Leishmaniasis--Cutaneous

Article	Year
Effect of HIV protease inhibitors on New World Leishmania. Parasitology international, 2012, Volume: 61, Issue:4 The incidence of HIV/Leishmania co-infection decreases after antiretroviral drug therapy; therefore, the in vitro and in vivo activity of three antiretroviral drugs against Leishmania (Viannia) braziliensis and L. (L.) amazonensis was evaluated. Different concentrations of indinavir (IDV), atazanavir (ATV), and ritonavir (RTV) were added to promastigote cultures, and the 50% inhibitory concentration (IC50) was determined. IDV and RTV were also evaluated against intracellular amastigotes, and the Infection Index determined. BALB/c mice, infected with L. (L.) amazonensis in the left footpad, were treated orally with IDV and RTV for 30 days, and monitored by measuring the footpad thickness and parasite load of regional lymph nodes and spleen. For promastigotes, IDV exhibited an IC50 value of 100 μM against L.(L.) amazonensis. The RTV IC50 for L. (L.) amazonensis and L. (V.) braziliensis were 40 and 2.3 μM, respectively, and the ATV IC50 for L. (V.) braziliensis was 266 μM. For intracellular amastigotes, IDV (25, 50, and 100 μM) significantly decreased the Infection Index of L. (L.) amazonensis (56.8%, 47.9%, and 65.0%) and L. (V.) braziliensis (37.8%, 48.7%, and 43.2%). RTV (12.5, 25, and 50 μM) decreased the infection index of L. (L.) amazonensis by 26.3%, 42.4%, and 44.0%, and that of L. (V.) braziliensis by 27.6%, 37.3%, and 39.2%. Antiretroviral-treated mice had a significant reduction in footpad thickness after the third week of IDV and after the fifth week of RTV treatment. However, there was no reduction in parasite load. These results suggest that IDV and RTV have anti-Leishmania activity, but only in higher concentrations. Topics: Amphotericin B; Animals; Antiprotozoal Agents; Atazanavir Sulfate; Dose-Response Relationship, Drug; HIV Protease Inhibitors; Indinavir; Leishmania; Leishmaniasis, Cutaneous; Mice; Oligopeptides; Pyridines; Ritonavir	2012
Post-kala-azar dermal leishmaniasis during highly active antiretroviral therapy in an AIDS patient infected with Leishmania infantum. The Journal of infection, 2000, Volume: 40, Issue:2 We report a case of post-kala-azar dermal leishmaniasis (PKDL) in a woman with AIDS which occurred 13 months after a diagnosis of visceral leishmaniasis concomitantly with immunological recovery induced by highly active retroviral therapy. Cytokine pattern at the time of visceral leishmaniasis and PKDL diagnosis was studied and pathogenic implications were discussed. Topics: Adult; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Indinavir; Lamivudine; Leishmania infantum; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Stavudine	2000

Article

Year

Effect of HIV protease inhibitors on New World Leishmania.

Parasitology international, 2012, Volume: 61, Issue:4

The incidence of HIV/Leishmania co-infection decreases after antiretroviral drug therapy; therefore, the in vitro and in vivo activity of three antiretroviral drugs against Leishmania (Viannia) braziliensis and L. (L.) amazonensis was evaluated. Different concentrations of indinavir (IDV), atazanavir (ATV), and ritonavir (RTV) were added to promastigote cultures, and the 50% inhibitory concentration (IC50) was determined. IDV and RTV were also evaluated against intracellular amastigotes, and the Infection Index determined. BALB/c mice, infected with L. (L.) amazonensis in the left footpad, were treated orally with IDV and RTV for 30 days, and monitored by measuring the footpad thickness and parasite load of regional lymph nodes and spleen. For promastigotes, IDV exhibited an IC50 value of 100 μM against L.(L.) amazonensis. The RTV IC50 for L. (L.) amazonensis and L. (V.) braziliensis were 40 and 2.3 μM, respectively, and the ATV IC50 for L. (V.) braziliensis was 266 μM. For intracellular amastigotes, IDV (25, 50, and 100 μM) significantly decreased the Infection Index of L. (L.) amazonensis (56.8%, 47.9%, and 65.0%) and L. (V.) braziliensis (37.8%, 48.7%, and 43.2%). RTV (12.5, 25, and 50 μM) decreased the infection index of L. (L.) amazonensis by 26.3%, 42.4%, and 44.0%, and that of L. (V.) braziliensis by 27.6%, 37.3%, and 39.2%. Antiretroviral-treated mice had a significant reduction in footpad thickness after the third week of IDV and after the fifth week of RTV treatment. However, there was no reduction in parasite load. These results suggest that IDV and RTV have anti-Leishmania activity, but only in higher concentrations.

Topics: Amphotericin B; Animals; Antiprotozoal Agents; Atazanavir Sulfate; Dose-Response Relationship, Drug; HIV Protease Inhibitors; Indinavir; Leishmania; Leishmaniasis, Cutaneous; Mice; Oligopeptides; Pyridines; Ritonavir

2012

Post-kala-azar dermal leishmaniasis during highly active antiretroviral therapy in an AIDS patient infected with Leishmania infantum.

The Journal of infection, 2000, Volume: 40, Issue:2

We report a case of post-kala-azar dermal leishmaniasis (PKDL) in a woman with AIDS which occurred 13 months after a diagnosis of visceral leishmaniasis concomitantly with immunological recovery induced by highly active retroviral therapy. Cytokine pattern at the time of visceral leishmaniasis and PKDL diagnosis was studied and pathogenic implications were discussed.

Topics: Adult; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Indinavir; Lamivudine; Leishmania infantum; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Stavudine

2000