indinavir-sulfate has been researched along with Hypoglycemia* in 2 studies
2 other study(ies) available for indinavir-sulfate and Hypoglycemia
| Article | Year |
|---|---|
Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation.
GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis. However, the role of insulin-responsive GLUT4 in the central nervous system has not been well characterized. To assess its importance, a selective knockout of brain GLUT4 (BG4KO) was generated by crossing Nestin-Cre mice with GLUT4-floxed mice. BG4KO mice had a 99% reduction in GLUT4 protein expression throughout the brain. Despite normal feeding and fasting glycemia, BG4KO mice were glucose intolerant, demonstrated hepatic insulin resistance, and had reduced glucose uptake in the brain. In response to hypoglycemia, BG4KO mice had impaired glucose sensing, noted by impaired epinephrine and glucagon responses and impaired Topics: Animals; Blood Glucose; Blotting, Western; Brain; Diet, High-Fat; Epinephrine; Glucagon; Glucose; Glucose Clamp Technique; Glucose Intolerance; Glucose Tolerance Test; Glucose Transporter Type 4; Homeostasis; Hypoglycemia; Hypothalamus; In Vitro Techniques; Indinavir; Insulin Resistance; Male; Mice; Mice, Knockout; Neurons; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2017 |
Short-term treatment with indinavir fails to reduce the glucose requirement in a patient with malignant insulinoma.
Topics: Aged; Blood Glucose; Female; Glucose; HIV Protease Inhibitors; Humans; Hypoglycemia; Indinavir; Infusions, Intravenous; Insulin Resistance; Insulinoma; Pancreatic Neoplasms; Recurrence; Time Factors; Treatment Outcome | 2000 |