indican has been researched along with Uremia in 238 studies
*Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (8.40) | 18.7374 |
| 1990's | 12 (5.04) | 18.2507 |
| 2000's | 35 (14.71) | 29.6817 |
| 2010's | 125 (52.52) | 24.3611 |
| 2020's | 46 (19.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hosokawa, A; Motojima, M; Muraki, T; Yamato, H; Yoshioka, T | 2 |
| Asaba, H; Deguchi, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Deguchi, T; Endou, H; Kusuhara, H; Otagiri, M; Sugiyama, Y; Takadate, A | 1 |
| Benet, LZ; Frassetto, L; Huang, Y; Sun, H | 1 |
| Ding, F; Shen, Y; Shi, Y; Tian, H; Wang, Y; Zhu, Q | 1 |
| Borges, NA; Capo-Chichi, JCC; de Vargas Reis, DCM; Mafra, D; Nakao, LS | 1 |
| Brigant, B; Choukroun, G; Diouf, M; Fourdinier, O; Glorieux, G; Group-EUTox, OBOTEUTW; Massy, ZA; Metzinger, L; Metzinger-Le Meuth, V; Pletinck, A; Vanholder, R; Verbeke, F | 1 |
| Ahmed, S; Carlier, A; Giselbrecht, S; King, J; Masereeuw, R; Mihaila, SM; Truckenmüller, R | 1 |
| Arinze, N; Belghasem, M; Chitalia, VC; Dember, LM; Lee, N; Lotfollahzadeh, S; Napoleon, MA; Ravid, K; Richards, S; Russell, TL; Walker, JA; Whelan, SA; Yoo, SB | 1 |
| Carriazo, S; Franssen, CFM; Gansevoort, RT; Gesualdo, L; Hafez, G; Liabeuf, S; Malyszko, J; Massy, ZA; Mayer, C; Nitsch, D; Ortiz, A; Pepin, M; Pešić, V; Viggiano, D; Wiecek, A | 1 |
| Berg, AH; Karumanchi, SA; Kumar, S | 1 |
| Burtey, S; Cerini, C; McKay, N; Poitevin, S; Vial, R | 1 |
| Ando, T; Itoh, H; Mimata, H; Oda, A; Ohno, K; Ono, H; Sato, B; Sato, H; Shin, T; Suzuki, Y; Tanaka, R | 1 |
| Gil, HW; Kim, DS; Kim, SW | 1 |
| Burtey, S; Glorieux, G; Nigam, SK; Vanholder, R | 1 |
| Lowenstein, J; Meijers, B | 1 |
| Abdelrasoul, A; Daneshamouz, S; Eduok, U; Shoker, A | 1 |
| Blanco, IJ; Lee, S; Meyer, TW; Plummer, NS; Sirich, TL | 1 |
| Koppe, L; Soulage, CO | 1 |
| Bouchouareb, D; Brunet, P; Burtey, S; Dou, L; Ebersolt, M; Mallmann, C; Mc-Kay, N; Sallée, M; Santana Machado, T | 1 |
| Abe, E; Alvarez, JC; Fabresse, N; Lamy, E; Larabi, IA; Massy, ZA; Rigothier, C | 1 |
| Chen, Y; Jin, H; Li, R; Li, Y; Wei, J; Zhang, P; Zhang, Z | 1 |
| Huang, L; Liu, L; Liu, XY; Liu, YF; Lu, C; Tang, MY; Wu, L; Zhang, C | 1 |
| Hasegawa, M; Hori, H; Nakai, S; Nakatani, M; Ohashi, A; Tsuboi, N; Tsuchida, K | 1 |
| Alvarez, JC; Bénard, A; Catros, S; Combe, C; Larabi, I; Massy, Z; Quintin, O; Rigothier, C; Samot, J | 1 |
| Ieda, M; Tajiri, K; Yamagami, F; Yumino, D | 1 |
| Bohnen, G; Dias, GF; Grobe, N; Kotanko, P; Moreno-Amaral, AN; Pecoits-Filho, R; Tozoni, SS | 1 |
| Chen, P; Fang, JT; Hsiao, YS; Huang, CH; Juang, RS; Liu, ZW; Sahoo, S; Yen, SC | 1 |
| Arinze, N; Belghasem, ME; Chitalia, VC; Francis, J; Kolachalama, VB; Lee, N; Ravid, K; Richards, S; Sherr, D; Tashjian, JY; Walker, JA; Whelan, SA; Yoo, SB | 1 |
| Lin, CJ; Lin, FH; Sun, CY; Wu, CC; Wu, CJ; Wu, V | 1 |
| Burtey, S; Lano, G; Sallée, M | 1 |
| Huang, PH; Liou, JY; Shih, YC; Tarng, DC; Wang, SC; Wu, CC | 1 |
| Burtey, S; Corbeau, P; Cristol, JP; Dunyach-Remy, C; Lavigne, JP; Moranne, O; Olivier, V; Sutra, T | 1 |
| Couttenye, MM; De Paepe, K; Glorieux, G; Gryp, T; Joossens, M; Kerckhof, FM; Speeckaert, M; Van Biesen, W; Van de Wiele, T; Vaneechoutte, M; Vanholder, R; Verbeke, F | 1 |
| Espi, M; Fouque, D; Koppe, L; Thaunat, O | 1 |
| Chang, JF; Chen, YW; Hsieh, CY; Hung, CF; Liang, SS; Lin, CC; Liou, JC; Lu, KC; Wu, MS | 1 |
| Hermanowicz, JM; Kalaska, B; Kaminski, TW; Karbowska, M; Nosek, K; Pawlak, D; Tankiewicz-Kwedlo, A; Wisniewska, RJ | 1 |
| Flissi, N; Gallet, M; Kamel, S; Lenglet, G; Liabeuf, S; Louvet, L; Massy, ZA; Six, I | 1 |
| Hwang, Y; Kim, HC; Kim, HY; Lee, GH; Lee, SJ; Lee, WW; Yoo, TH; Yoon, CE | 1 |
| Chen, WJ; Hsu, YJ; Lai, YJ; Lee, JL; Wu, ST | 1 |
| Chao, CT; Lin, SH | 1 |
| Anansilp, K; Kamprom, W; Mas-Oodi, S; Rattanasompattikul, M; Supokawej, A; Tawonsawatruk, T | 1 |
| Alvarenga, L; Cardozo, LFMF; de S G Moreira, L; Fouque, D; Lima, JD; Mafra, D; Nakao, LS; Rodrigues, SD; Salarolli, RT; Teixeira, KTR | 1 |
| De Bacquer, D; Glorieux, G; Neirynck, N; Pletinck, A; Schepers, E; Speeckaert, M; Van Biesen, W; Vanholder, R; Verbeke, F | 1 |
| Chung, FM; Hsuan, CF; Hung, WC; Lee, TL; Lee, YJ; Lu, YC; Tsai, IT; Wang, CP; Wei, CT; Wu, CC; Yu, TH | 1 |
| Domon, M; Goto, S; Goto, Y; Ito, T; Narita, I; Sasahara, K; Yamaguchi, K; Yamamoto, S | 1 |
| Maruyama, T; Nishi, K; Otagiri, M; Sakurama, K; Watanabe, H; Yamasaki, K | 1 |
| Ludwig, J; Pfaendtner, J; Smith, J | 1 |
| da Cunha, RS; Dalboni, MA; Favretto, G; Flores Santos, A; Franco, CRC; Gregório, PC; Leitolis, A; Massy, Z; Schiefer, EM; Stinghen, AEM | 1 |
| Cosola, C; Gesualdo, L; Ranieri, E; Rocchetti, MT | 1 |
| Bonzi, YJ; Coulibaly, G; Hien, S; Mande, AR; Sawadogo, A; Yanogo, M | 1 |
| Armelloni, S; Caldiroli, L; Callegari, ML; Margiotta, E; Messa, P; Miragoli, F; Rizzo, V; Vettoretti, S; Zanoni, F | 1 |
| Chang, JF; Chang, SW; Hsieh, CY; Liou, JC; Lu, KC; Wang, TM; Wu, CC; Wu, MS; Zheng, CM | 1 |
| Gesualdo, L; Migliori, M; Panichi, V; Pizzarelli, F; Rocchetti, MT; Rosati, A; Scatena, A | 1 |
| Cunha, RS; Favretto, G; Gregório, PC; Maciel, RAP; Pecoits-Filho, R; Sassaki, GL; Souza, LM; Souza, WM; Stinghen, AEM; Toledo, MG | 1 |
| Borges, NA; Brito, JS; Esgalhado, M; Mafra, D; Magliano, DC; Soulage, CO | 1 |
| de Loor, H; Deltombe, O; Dhondt, A; Eloot, S; Glorieux, G; Meijers, B; Van Biesen, W | 1 |
| Ei, I; Gejyo, F; Goto, S; Iguchi, A; Kaneko, Y; Kazama, JJ; Narita, I; Omori, K; Sato, M; Sato, Y; Suzuki, Y; Takahashi, Y; Wakamatsu, T; Yamamoto, S | 1 |
| Banerjee, T; Coresh, J; Hostetter, TH; Hwang, S; Melamed, ML; Meyer, TW; Plummer, NS; Powe, NR; Shafi, T; Sirich, TL | 1 |
| Kaminski, TW; Karbowska, M; Marcinczyk, N; Misztal, T; Pawlak, D; Rusak, T; Smyk, L | 1 |
| Charalambopoulou, G; Gerritsen, KGF; Giasafaki, D; Pavlenko, D; Stamatialis, D; Steriotis, T; van Geffen, E | 1 |
| Evenepoel, P; Glorieux, G; Meijers, B | 1 |
| Chang, YL; Hsu, SC; Hsu, YJ; Huang, SM; Lin, CY; Shih, CC; Tsai, CS | 1 |
| Abe, T; Ito, S; Kisu, K; Matsumoto, Y; Mishima, E; Miura, D; Mori, T; Morikawa-Ichinose, T; Niwa, T; Oe, Y; Saigusa, D; Saito, R; Sato, E; Sato, H; Sekimoto, A; Takahashi, N; Tomioka, Y; Uchida, T | 1 |
| Alousi, F; Belghasem, ME; Chang, GH; Chitalia, VC; Dember, LM; Francis, JM; Gibson, CM; Kolachalama, VB; Matsuura, S; Ravid, K; Rijal, K; Shashar, M; Shivanna, S; Walker, J | 1 |
| Ao, UI; Chan, DC; Chen, YS; Chiang, CK; Huang, JW; Hung, KY; Jheng, JR; Tarng, DC | 1 |
| Atherton, JG; Bissler, J; Hains, DS; Lindner, E; Pendley, BD | 1 |
| Beelen, RHJ; Hordijk, PL; van Bezu, J; Vervloet, MG; Vila Cuenca, M | 1 |
| Chien, SW; Hou, YC; Lim, PS; Lin, YF; Liu, WC; Lu, KC; Shyu, JF; Wu, CC; Zheng, CM | 1 |
| Yamamoto, S | 1 |
| Chen, S; Chen, X; Gao, S; Mao, Z; Mei, C; Pan, X; Ruan, M; Xing, X; Xu, J | 1 |
| Bonan, NB; Dias, GF; Kotanko, P; Kuntsevich, V; Moreno-Amaral, AN; Nakao, LS; Pecoits Filho, R; Rodrigues, S; Steiner, TM; Tozoni, SS | 1 |
| Asai, H; Hirata, J; Watanabe-Akanuma, M | 1 |
| Liu, WC; Lu, KC; Tomino, Y | 1 |
| Jerman, A; Osredkar, J; Pajek, J; Pajek, M; Ponikvar, JB | 1 |
| Boullier, A; Busato, V; Cunha, RS; Dolenga, CJR; Franco, CRC; Gregório, PC; Maciel, RAP; Massy, ZA; Nakao, LS; Pecoits-Filho, R; Stinghen, AEM | 1 |
| Ding, F; Li, Y; Liu, T; Ma, S; Shi, Y; Tian, H; Wang, W; Wang, Y; Zhu, Q | 1 |
| Chinnappa, S; Glorieux, G; Mooney, A; Tu, YK; Vanholder, R; Yeh, YC | 1 |
| Hoyer, FF; Nahrendorf, M | 1 |
| Glorieux, G; Liabeuf, S; Massy, ZA; Van Biesen, W; Vanholder, R; Vanmassenhove, J; Veldeman, L | 1 |
| da Silva, BP; de Castro Moreira, ME; Hermsdorff, HH; Lopes, RCSO; Mantovani, HC; Martino, HSD; Queiroz, VAV; Theodoro, JMV | 1 |
| Cao, W; Duan, J; Guo, J; Leng, J; Li, J; Shang, E; Shen, Z; Wang, N; Wang, Y; Xu, X; Zhu, Z; Zou, N | 1 |
| Cai, J; Chen, J; Ding, X; Gu, Y; Hu, J; Ning, Y; Shi, Y; Song, N; Zhang, H; Zhang, X | 1 |
| Asakura, M; Asano, Y; Asanuma, H; Chung, H; Fukuda, H; Funayama, M; Ihara, M; Imazu, M; Ito, S; Kitakaze, M; Min, KD; Minamino, T; Morita, T; Ogai, A; Sugimachi, M; Takahama, H; Takashima, S | 1 |
| Adesso, S; Autore, G; Marzocco, S; Nishijima, F; Piaz, FD; Pinto, A; Popolo, A; Raffaele Di Iorio, B; Rapa, SF; Ruocco, M | 1 |
| Jeon, EY; Kim, SJ; Ryu, JH | 1 |
| Bennis, Y; Bodeau, S; Choukroun, G; Cluet, Y; Combe, C; Dussol, B; El Esper, N; Fouque, D; Liabeuf, S; Titeca-Beauport, D; Ureña, P | 1 |
| Bi, X; Han, W; He, T; Huang, Y; Liu, C; Liu, Y; Xiao, T; Xiong, J; Xu, X; Yang, K; Yu, Y; Zhang, B; Zhang, J; Zhao, J; Zheng, C | 1 |
| Deltombe, O; Eloot, S; Glorieux, G; Marzouki, S; Masereeuw, R; Schneditz, D | 1 |
| Nolin, TD; Prokopienko, AJ; Stubbs, JR; West, RE | 1 |
| Beck, T; Erlenkötter, A; Goettsch, C; Jankowski, J; Jankowski, V; Noels, H; Oleschko, K; Speer, T; Steppan, S; Sternkopf, M; Thoröe-Boveleth, S; Tschulena, U | 1 |
| Bolati, D; Nishijima, F; Niwa, T; Shimizu, H; Yisireyili, M | 1 |
| Niwa, T | 5 |
| Higashijima, Y; Nangaku, M; Tanaka, T; Yamaguchi, J | 1 |
| Evenepoel, P; Meijers, B | 1 |
| Brunet, P; Cohen, G; De Vriese, A; Eloot, S; Glorieux, G; Gondouin, B; Pletinck, A; Rops, A; Schepers, E; Van Biesen, W; Van de Voorde, J; van der Vlag, J; Van Landschoot, M; Vanholder, R | 1 |
| Campbell, KL; Dimeski, G; Haluska, BA; Hawley, CM; Isbel, NM; Johnson, DW; Kaisar, OM; McWhinney, BC; Rossi, M; Stanton, T; Ungerer, JP | 1 |
| Dhondt, A; Eloot, S; Glorieux, G; Neirynck, N; Van Biesen, W; Vanholder, R | 1 |
| Gil, HW; Hong, SY; Kim, YH; Kwak, KA; Song, HY | 1 |
| Hwang, YJ; Jeong, KT; Park, JH; Yun, MO | 1 |
| Devine, E; Jankovski, J; Krieter, DH; Lemke, HD; Rüth, M | 1 |
| Burdzińska, A; Gala, K; Idziak, M; Pączek, L; Pędzisz, P | 1 |
| Ito, S; Yoshida, M | 1 |
| Exner, M; Gmeiner, BM; Hermann, M; Jirovetz, L; Kapiotis, S; Laggner, H; Praschberger, M; Wanner, J | 1 |
| Basnayake, K; Boyd, O; Davenport, A; Holt, S; Howell, CA; Mikhalovsky, SV; Phillips, GJ; Pletzenauer, R; Sandeman, SR; Standen, G; Zheng, Y | 1 |
| Cheng, BC; Chiou, TT; Hsu, CY; Lee, CT; Lee, YT; Liao, SC; Ng, HY; Tain, YL; Wu, CH; Yang, CC | 1 |
| Campbell, KL; Coombes, JS; Hawley, CM; Isbel, N; Johnson, DW; McWhinney, BC; Rossi, M; Stanton, T; Ungerer, JP; Vesey, DA; Weston, KS | 1 |
| Glorieux, G; Nagler, EV; Pletinck, A; Schepers, E; Vanholder, R | 1 |
| Boullier, A; Chillon, JM; Massy, ZA; Stinghen, AE | 1 |
| Barnes, KJ; Miners, JO; Polasek, TM; Rowland, A | 1 |
| Choukroun, G; Desjardins, L; Kamel, S; Lemke, HD; Liabeuf, S; Louvet, L; Massy, ZA; Oliveira, RB; Vanholder, R | 1 |
| Furukubo, T; Izumi, S; Minegaki, T; Nishiguchi, K; Oda, T; Ogino, H; Shinmoto, T; Tachiki, H; Tsujimoto, M; Uchiyama, H; Yamakawa, T; Yoshida, T | 1 |
| Calleros, L; Carracedo, J; García-Jérez, A; Luengo, A; Ramírez-Chamond, R; Rodriguez-Puyol, D; Rodriguez-Puyol, M | 1 |
| Krum, H; Lekawanvijit, S | 1 |
| Banerjee, T; Dolgalev, I; Heguy, A; Jhawar, S; Kassem, H; Lowenstein, J; Ramirez-Valle, F; Singh, P; Torres, D; Zavadil, J | 1 |
| Al-Rabadi, L; Balcells, M; Belghasim, M; Chitalia, VC; Edelman, ER; Francis, J; Kolandaivelu, K; Pollastri, MP; Shashar, M; Sherr, DH; Shivanna, S; Weinberg, J; Zhang, A | 1 |
| Lin, CJ; Wu, CJ; Wu, PC; Wu, V | 1 |
| Chen, HH; Lin, CJ; Liou, TC; Liu, HL; Pan, CF; Sun, FJ; Wu, CJ; Wu, PC | 1 |
| Kawamura, K; Kazama, JJ; Maruyama, T; Matsuo, K; Matsuto, T; Narita, I; Omori, K; Takahashi, Y; Watanabe, H; Yamamoto, S | 1 |
| Chillon, JM; Drueke, TB; Gross, P; Massy, ZA; Poirot, S; Rémond, MC; Six, I | 1 |
| Deltombe, O; Dhondt, A; Eloot, S; Glorieux, G; Massy, Z; Van Biesen, W | 1 |
| Aoki, K; Fukui, A; Fukunaga, N; Kondo, H; Nawata, T; Saito, S; Shibata, H; Shimada, T; Takahashi, N; Teshima, Y | 1 |
| Cui, D; Dong, W; Gao, C; Ji, S; Qi, Y; Shi, J; Song, W | 1 |
| Fouque, D; Mafra, D; Saldanha, JF; Soulage, CO; Stockler-Pinto, MB; Yi, D | 1 |
| Chen, YL; Huang, TM; Liang, CJ; Liu, CW; Peng, YS; Shen, WC; Tsai, JS; Tseng, YC; Wang, SH; Wu, VC; Young, GH | 1 |
| Chen, JW; Huang, HL; Huang, PH; Hung, SC; Kuo, KL; Lin, CC; Lin, SJ; Tarng, DC; Tsai, TH; Wang, CH | 1 |
| Hoffmann, M; Liu, H; Narayanan, R; Surapaneni, S | 1 |
| Arake, R; Enoki, Y; Fukagawa, M; Imafuku, T; Ishima, Y; Kotani, S; Maruyama, T; Matsushita, K; Nakajima, M; Otagiri, M; Sugimoto, R; Tanaka, M; Tominaga, Y; Watanabe, H | 1 |
| Aviles, DH; Blanchard, EE; Crespo-Salgado, J; Ferris, M; Greenbaum, LA; Kallash, M; Stewart, T; Taylor, CM; Vehaskari, VM; Wang, G; Zhang, Q | 1 |
| Liabeuf, S; Massy, ZA; Villain, C | 1 |
| Abe, T; Ito, S; Kisu, K; Koizumi, K; Kudo, T; Kurasawa, N; Mishima, E; Miura, D; Mokudai, T; Mori, T; Morikawa-Ichinose, T; Naganuma, E; Niwa, T; Niwano, Y; Oba-Yabana, I; Oe, Y; Saigusa, D; Saito, R; Sato, E; Sato, H; Sugawara, S; Suzuki, A; Suzuki, C; Takahashi, N | 1 |
| Hazen, SL; Skye, SM | 1 |
| Beck, GJ; Chertow, GM; Fong, K; Kliger, AS; Larive, B; Levin, NW; Meyer, TW; Plummer, NS; Sirich, TL | 1 |
| Wyatt, CM; Yacoub, R | 1 |
| Hamada, A; Iwata, K; Kusumoto, M; Matsuzaki, T; Morisaki, T; Saito, H; Yokoo, K | 1 |
| Hostetter, TH; Meyer, TW; Raff, AC | 1 |
| Dhondt, A; Eloot, S; Hostetter, T; Meert, N; Meyer, T; Van Biesen, W; Vanholder, R | 1 |
| Canaud, B; Chenine, L; Hackl, A; Krieter, DH; Lemke, HD; Moragues, HL; Rodriguez, A; Wanner, C | 1 |
| Adijiang, A; Niwa, T | 1 |
| Fridolin, I; Jerotskaja, J; Lauri, K; Luman, M; Tanner, R | 1 |
| Fasching, A; Fujita, T; Hansell, P; Kawakami, T; Nangaku, M; Nishijima, F; Nordquist, L; Palm, F; Tanaka, T | 1 |
| Adijiang, A; Higuchi, Y; Nishijima, F; Niwa, T; Shimizu, H | 1 |
| Furukubo, T; Higuchi, K; Hirata, S; Izumi, S; Nishiguchi, K; Otagiri, M; Shima, D; Takara, K; Tsujimoto, M; Yamakawa, T; Yokota, H | 1 |
| Ezawa, A; Itoh, Y; Kikuchi, K; Murakami, K; Niwa, T; Tateoka, R | 1 |
| Hsu, HJ; Hsu, KH; Lee, CC; Lin, CY; Sun, CY; Tsai, CJ; Tzen, CY; Wang, YC; Wu, IW; Wu, MS | 1 |
| Fujii, H; Fukagawa, M; Nakai, K | 1 |
| Maruyama, T; Miyamoto, Y; Otagiri, M; Watanabe, H | 1 |
| Fujii, H; Fukagawa, M; Goto, S; Kita, T; Yoshiya, K | 1 |
| Kouznetsova, VL; Nagle, MA; Nigam, SK; Tsigelny, IF; Wikoff, WR | 1 |
| Haddad, DJ; Kharait, S; Springer, ML | 1 |
| Argilés, A; Bergé-Lefranc, D; Brunet, P; Calaf, R; Cerini, C; Charpiot, P; Dignat-George, F; Dou, L; Génovésio, C; Gondouin, B; Jourde-Chiche, N; Morange, S; Rathelot, P; Verhaeghe, P | 1 |
| Chiang, CK; Fujita, T; Inagi, R; Nangaku, M; Tanaka, T | 1 |
| Kiss, I | 1 |
| Drüeke, TB; Liabeuf, S; Massy, ZA | 1 |
| Chiang, CK; Nangaku, M; Tanaka, T | 1 |
| Glorieux, G; Neirynck, N; Pletinck, A; Schepers, E; Vanholder, R | 1 |
| Niwa, T; Shimizu, H | 1 |
| Meyer, TW | 1 |
| Chang, SC; Sun, CY; Wu, MS | 2 |
| Hostetter, TH; Meyer, TW | 1 |
| Ishima, Y; Kadowaki, D; Kotani, S; Maruyama, T; Miyamoto, Y; Miyamura, S; Nakajima, M; Noguchi, T; Otagiri, M; Watanabe, H | 1 |
| Argiles, A; Cohen, G; De Smet, R; Duranton, F; Jankowski, J; Rodriguez, M; Vanholder, R | 1 |
| Kompa, AR; Krum, H; Lekawanvijit, S; Liu, S; Wang, BH | 1 |
| Huang, JY; Huang, WH; Hung, CC; Yang, CW | 1 |
| Nishijima, F; Niwa, T; Shimizu, H; Yisireyili, M | 1 |
| Eloot, S; Glorieux, G; Neirynck, N; Pletinck, A; Schepers, E; Vanholder, R | 1 |
| Hirashiki, A; Kondo, T; Murohara, T; Niwa, T; Okamoto, R; Okumura, T; Shimazu, S; Shinoda, N; Takeshita, K; Yamada, T | 1 |
| Kelly, DJ; Kompa, AR; Krum, H; Lekawanvijit, S; Wang, BH | 1 |
| Arund, J; Fridolin, I; Tanner, R; Uhlin, F | 1 |
| Evenepoel, P; Mathieu, C; Meijers, B; Overbergh, L; Vanderschueren, D; Viaene, L | 1 |
| Hsu, SC; Hsu, YJ; Huang, SM; Lee, HS; Lin, CY; Lin, SH; Shih, CC; Tsai, CS | 1 |
| Balcells, M; Bosch, I; Chitalia, VC; Edelman, ER; Kolandaivelu, K; Martorell, J; Shivanna, S | 1 |
| Boelaert, J; Eloot, S; Glorieux, G; Lynen, F; Sandra, P; Van Landschoot, M; Vanholder, R; Waterloos, MA | 1 |
| Brettschneider, F; Jankowski, J; Jankowski, V; Krause, A; Kühne, S; Passlick-Deetjen, J; Peter, M; Steppan, S; Tölle, M; von der Giet, M; Zidek, W | 1 |
| Buoncristiani, U; De Smet, R; Fagugli, RM; Lameire, N; Vanholder, R | 1 |
| Asaba, H; Deguchi, T; Hosoya, K; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Imai, E; Oka, K; Okada, N; Shoji, T; Takabatake, Y; Takahito, I; Togawa, M; Tsubakihara, Y | 1 |
| CSASZAR, ES; SZUCS, O | 1 |
| Berland, Y; Brunet, P; Cerini, C; Dou, L | 1 |
| Berland, Y; Bertrand, E; Brunet, P; Cerini, C; Dou, L; Faure, V; Sampol, J; Vanholder, R | 1 |
| Niwa, T; Takayama, F; Taki, K | 1 |
| Berland, Y; Brunet, P; Cerini, C; Dignat-George, F; Dou, L; Faure, V; Sabatier, F; Sampol, J | 1 |
| Fujieda, A; Fukagawa, M; Hosokawa, A; Iwasaki, Y; Motojima, M; Nii-Kono, T; Uchida, M; Yamato, H | 2 |
| Niwa, T; Takayama, F; Taki, K; Tsuruta, Y | 1 |
| Davilas, A; Koupparis, M; Macheras, P; Valsami, G | 1 |
| Niwa, T; Taki, K; Tsuruta, Y | 1 |
| Boyd, JC; Bruns, DE; Haverstick, DM; Henrich, LM; Reynolds, VG | 1 |
| Berland, Y; Brunet, P; Cerini, C; Dignat-George, F; Dou, L; Faure, V; Jourde-Chiche, N | 1 |
| Iwasaki, Y | 1 |
| Grinenko, DV; Mikhalovsky, SV; Nikolaev, AV; Nikolaev, VG; Sakhno, LA; Sarnatskaya, VV; Yushko, LA | 1 |
| Enomoto, A; Niwa, T | 1 |
| Niwa, T; Tumur, Z | 1 |
| Bannai, K; Goto, S; Hayashi, H; Nishijima, F; Niwa, T; Owada, S | 1 |
| Bowmer, CJ; Lindup, WE | 1 |
| Dasgupta, A; Malik, S | 1 |
| Ise, M; Miyazaki, T; Niwa, T | 1 |
| Ise, M; Niwa, T | 1 |
| Bernard, BF; de Jong, M; Docter, R; Hennemann, G; Krenning, EP; Lim, CF | 1 |
| Aiba, Y; Hida, M; Koga, Y; Satoh, T; Sawamura, S; Suzuki, N | 1 |
| Ise, M; Miyazaki, T; Niwa, T; Seo, H | 1 |
| Miyazaki, T; Niwa, T; Nomura, T; Sugiyama, S; Tsukushi, S; Tsutsui, S | 1 |
| Ise, M; Miyazaki, T; Niwa, T; Owada, A; Shiigai, T; Tsubakihara, Y; Tsukushi, S | 1 |
| Dasgupta, A; Havlik, D | 1 |
| De Smet, R; Dhondt, A; Duym, P; Lameire, N; Lesaffer, G; Vanholder, R | 1 |
| Maruyama, T; Otagiri, M; Shimada, H; Takadate, A; Tsutsumi, Y | 1 |
| Aoyama, I; Ise, M; Miyazaki, T; Niwa, T; Seo, H | 1 |
| De Smet, R; Lameire, N; Vanholder, R | 1 |
| Kragh-Hansen, U; Otagiri, M; Sakai, T; Sako, T; Suenaga, A; Yamasaki, K | 1 |
| Dasgupta, A; Paul, A; Wells, A | 1 |
| Aoyama, I; Niwa, T; Shimokata, K | 1 |
| Barsotti, G; Giovannetti, S | 1 |
| Hashimoto, N; Hayashi, H; Ise, M; Maeda, K; Miyazaki, T; Niwa, T; Uehara, Y | 1 |
| Ise, M; Kodama, T; Maeda, K; Niwa, T; Sugano, M; Uehara, Y; Yazawa, T | 2 |
| Gerlag, PG; Peeters, JA; Schoots, AC | 1 |
| Kawashima, Y | 1 |
| Gulyassy, PF; Jarrard, EA; Stanfel, LA | 1 |
| Mabuchi, H; Nakahashi, H | 3 |
| Laganà, A; Liberti, A; Morgia, C; Tarola, AM | 1 |
| Gulyassy, PF; Jarrard, E; Stanfel, LA | 1 |
| Gulyassy, PF; Jarrard, E; Stanfel, L | 1 |
| Maeda, K; Niwa, T; Takeda, N; Tatematsu, A | 1 |
| Maeda, K; Niwa, T; Shibata, M; Takeda, N; Tatematsu, A | 1 |
| Barnett, AL; Veening, H | 1 |
| Eckfeldt, JH; Kershaw, M; McPhaul, L; Tilque, D | 1 |
| Dobbelstein, H | 1 |
| Jensen, OM | 1 |
| Black, DA | 1 |
| Müting, D | 1 |
44 review(s) available for indican and Uremia
| Article | Year |
|---|---|
Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?
Topics: Cerebrovascular Disorders; Humans; Indican; Renal Insufficiency, Chronic; Uremia; Uremic Toxins | 2021 |
Emotional and cognitive changes in chronic kidney disease.
Topics: Cerebrovascular Disorders; Cognition; Female; Humans; Indican; Male; Renal Insufficiency, Chronic; Uremia | 2022 |
What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis.
Topics: Female; Humans; Indican; Liver; Male; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Uremia; Uremic Toxins | 2022 |
The Evolving View of Uremic Toxicity.
Topics: Animals; Female; Humans; Indican; Kidney; Male; Rats; Toxins, Biological; Uremia; Uremic Toxins | 2022 |
Protein-bound uremic toxins (PBUTs) in chronic kidney disease (CKD) patients: Production pathway, challenges and recent advances in renal PBUTs clearance.
Topics: Humans; Indican; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin; Sulfates; Uremia; Uremic Toxins | 2021 |
Indoxyl sulfate in atherosclerosis.
Topics: Albumins; Atherosclerosis; Cardiovascular Diseases; Chronic Disease; Humans; Indican; Renal Insufficiency, Chronic; Uremia | 2023 |
Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications.
Topics: Animals; Atrial Fibrillation; Carbon; Humans; Indican; Oxides; Renal Insufficiency, Chronic; Toxins, Biological; Uremia | 2019 |
Indoxyl Sulfate, a Uremic Endotheliotoxin.
Topics: Animals; Cardiovascular Diseases; Endothelium, Vascular; Humans; Indican; Prognosis; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors; Signal Transduction; Toxins, Biological; Uremia | 2020 |
Chronic Kidney Disease-Associated Immune Dysfunctions: Impact of Protein-Bound Uremic Retention Solutes on Immune Cells.
Topics: Animals; Cresols; Humans; Immune System; Immunity, Cellular; Immunity, Humoral; Immunity, Innate; Indican; Kidney; Protein Binding; Renal Insufficiency, Chronic; Sulfuric Acid Esters; T-Lymphocytes; Uremia | 2020 |
Uremic Toxins and Vascular Dysfunction.
Topics: Animals; Blood Vessels; Cresols; Fibroblast Growth Factor-23; Humans; Indican; Inflammation Mediators; Oxidative Stress; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremia; Vascular Diseases | 2020 |
Uremic Vascular Calcification: The Pathogenic Roles and Gastrointestinal Decontamination of Uremic Toxins.
Topics: Clinical Trials as Topic; Decontamination; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Indican; Isoquinolines; Renal Insufficiency, Chronic; Sulfonamides; Toxins, Biological; Uremia; Vascular Calcification | 2020 |
Protein-Bound Uremic Toxins and Immunity.
Topics: Adaptive Immunity; Cardiovascular Diseases; Cresols; Gastrointestinal Microbiome; Humans; Immunity, Innate; Indican; Inflammation; Renal Insufficiency, Chronic; Sulfuric Acid Esters; T-Lymphocytes; Toxins, Biological; Uremia | 2021 |
Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins.
Topics: Animals; Cardiovascular Diseases; Glucuronates; Humans; Indican; Indoleacetic Acids; Indoles; Models, Biological; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Uremia | 2017 |
Generation, clearance, toxicity, and monitoring possibilities of unaccounted uremic toxins for improved dialysis prescriptions.
Topics: Humans; Indican; Kidney Failure, Chronic; Renal Dialysis; Toxins, Biological; Urea; Uremia | 2018 |
Effect of uremic toxin-indoxyl sulfate on the skeletal system.
Topics: Apoptosis; Bone and Bones; Cell Differentiation; Humans; Indican; Osteoclasts; Toxins, Biological; Uremia | 2018 |
Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β
Topics: Amyloidosis; Animals; Atherosclerosis; Awards and Prizes; beta 2-Microglobulin; Humans; Indican; Lipoproteins, HDL; Macrophages; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors; Uremia | 2019 |
Impacts of Indoxyl Sulfate and p-Cresol Sulfate on Chronic Kidney Disease and Mitigating Effects of AST-120.
Topics: Adsorption; Animals; Carbon; Cresols; Humans; Indican; Oxides; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2018 |
Removal of protein-bound uraemic toxins by haemodialysis.
Topics: Blood Proteins; Cresols; Furans; Human Umbilical Vein Endothelial Cells; Humans; Indican; Membranes, Artificial; Propionates; Reactive Oxygen Species; Renal Dialysis; Sulfuric Acid Esters; Uremia | 2013 |
Protein-bound uremic toxins: new culprits of cardiovascular events in chronic kidney disease patients.
Topics: Animals; Atherosclerosis; Carbon; Cresols; Humans; Indican; Oxides; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2014 |
The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review.
Topics: Animals; Cresols; Disease Models, Animal; Humans; Indican; Kidney; Models, Biological; Protein Binding; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2014 |
Cardiorenal syndrome: role of protein-bound uremic toxins.
Topics: Cardio-Renal Syndrome; Cresols; Humans; Indican; Proteinuria; Renal Insufficiency, Chronic; Uremia | 2015 |
Meta-Analysis of the Associations of p-Cresyl Sulfate (PCS) and Indoxyl Sulfate (IS) with Cardiovascular Events and All-Cause Mortality in Patients with Chronic Renal Failure.
Topics: Biomarkers; Cardiovascular Diseases; Cresols; Humans; Indican; Kidney Failure, Chronic; Risk Factors; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2015 |
Protein-bound toxins: has the Cinderella of uraemic toxins turned into a princess?
Topics: Animals; Cardiovascular Diseases; Cresols; Humans; Indican; Indoleacetic Acids; Proteins; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremia | 2016 |
New insights into uremic toxicity.
Topics: Anorexia; Cresols; Humans; Indican; Oxidative Stress; Proteins; Renal Dialysis; Sulfuric Acid Esters; Syndrome; Uremia | 2008 |
Uremic toxicity of indoxyl sulfate.
Topics: Animals; Carbon; Free Radicals; Humans; Indican; Kidney; Osteoblasts; Oxides; Rats; Uremia | 2010 |
Indoxyl sulfate is a nephro-vascular toxin.
Topics: Adsorption; Animals; Carbon; Cardiovascular Diseases; Free Radicals; Glomerular Mesangium; Humans; Indican; Kidney Diseases; Kidney Tubules; Models, Biological; Oxidative Stress; Oxides; Proteins; Uremia | 2010 |
Uremic toxins and oral adsorbents.
Topics: Administration, Oral; Animals; Carbon; Chelating Agents; Humans; Indican; Kidney Failure, Chronic; Mice; Oxides; Polyamines; Protein Binding; Sevelamer; Uremia | 2011 |
[The uremic toxin, indoxyl sulfate, signifies cardio-renal risk and intestinal-renal relationship].
Topics: Biomarkers; Cardiovascular Diseases; Disease Progression; Humans; Indican; Intestinal Mucosa; Intestines; Kidney; Kidney Failure, Chronic; Risk Factors; Uremia | 2011 |
Protein-bound uremic toxins: new insight from clinical studies.
Topics: Cardiovascular Diseases; Cresols; Disease Progression; Heart; Humans; Indican; Kidney; Protein Binding; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2011 |
Dysregulated oxygen metabolism of the kidney by uremic toxins: review.
Topics: Animals; Cell Proliferation; Erythropoietin; Homeostasis; Humans; Hypoxia; Indican; Kidney; Kidney Failure, Chronic; Kidney Tubules; Oxidative Stress; Oxygen Consumption; Rats; Uremia | 2012 |
An update on protein-bound uremic retention solutes.
Topics: Adsorption; Blood Proteins; Carbon; Cresols; Humans; Indican; Kidney Failure, Chronic; Microspheres; Oxides; Protein Binding; Renal Dialysis; Sulfuric Acid Esters; Uremia | 2012 |
Indoxyl sulfate induces nephrovascular senescence.
Topics: Animals; Aorta; Cardiovascular Diseases; Cellular Senescence; Endothelial Cells; Gene Expression; Glucuronidase; Humans; Hypertension; Indican; Kidney Failure, Chronic; Kidney Tubules, Proximal; Klotho Proteins; NF-kappa B; Nitric Oxide; Rats; Reactive Oxygen Species; Uremia | 2012 |
The removal of protein-bound solutes by dialysis.
Topics: Adsorption; Blood Proteins; Cresols; Humans; Indican; Kidney; Proteins; Renal Dialysis; Sulfuric Acid Esters; Urea; Uremia | 2012 |
Uremic solutes from colon microbes.
Topics: Animals; Bacteria; Colon; Cresols; Fermentation; Humans; Indican; Intestinal Absorption; Kidney; Metagenome; Renal Dialysis; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2012 |
Normal and pathologic concentrations of uremic toxins.
Topics: beta 2-Microglobulin; Chronic Disease; Homocysteine; Humans; Indican; Kidney Diseases; Parathyroid Hormone; Toxins, Biological; Uremia; Uric Acid | 2012 |
An update on uremic toxins.
Topics: beta 2-Microglobulin; Biomarkers; Cardiovascular Diseases; Cresols; Dialysis Solutions; Fibroblast Growth Factor-23; Glucuronides; Guanidines; Humans; Indican; Peptides; Protein Binding; Renal Dialysis; Sulfuric Acid Esters; Urea; Uremia | 2013 |
Cardiorenal syndrome: the emerging role of protein-bound uremic toxins.
Topics: Carbon; Cardio-Renal Syndrome; Humans; Indican; Oxidative Stress; Oxides; Protein Binding; Proteinuria; Toxins, Biological; Uremia | 2012 |
Protein-bound uremic retention solutes.
Topics: Animals; Blood Proteins; Cresols; Furans; Hippurates; Homocysteine; Humans; Indican; Propionates; Renal Dialysis; Uremia | 2003 |
Uremic toxin and bone metabolism.
Topics: Aluminum; Bone and Bones; Bone Diseases; Bone Resorption; Chronic Kidney Disease-Mineral and Bone Disorder; Glycoproteins; Humans; Indican; Osteitis Fibrosa Cystica; Osteoprotegerin; Parathyroid Hormone; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; Toxins, Biological; Uremia; Vitamin D | 2006 |
[Uremic toxins and bone metabolism].
Topics: Animals; Bone and Bones; Humans; Indican; Osteoprotegerin; Uremia | 2007 |
Roles of organic anion transporters in the progression of chronic renal failure.
Topics: Animals; Biological Transport; Bone Diseases; Humans; Indican; Kidney Failure, Chronic; Organic Anion Transporters; Toxins, Biological; Uremia | 2007 |
Protein-bound uremic solutes: the forgotten toxins.
Topics: Animals; Cresols; Furans; Hippurates; Homocysteine; Humans; Indican; Intestinal Mucosa; Kinetics; Propionates; Protein Binding; Proteins; Renal Dialysis; Toxins, Biological; Uremia | 2001 |
Uremic intoxication.
Topics: Amines; Animals; Creatinine; Dogs; Guanidines; Humans; Hydroxy Acids; Indican; Kidney Failure, Chronic; Molecular Weight; Phenols; Renal Dialysis; Toxins, Biological; Urea; Uremia; Uric Acid | 1975 |
[Pathogenesis of uremia].
Topics: Acidosis; Aminobenzoates; Ammonia; Anemia; Animals; Butyrates; Cardiovascular Diseases; Central Nervous System Diseases; Cinnamates; Creatinine; Dogs; Endocrine System Diseases; Gastroenteritis; Glomerular Filtration Rate; Guanidines; Guanine; Guinea Pigs; Haplorhini; Hemorrhagic Disorders; Hominidae; Humans; In Vitro Techniques; Indican; Mice; Phenols; Phosphates; Pruritus; Pulmonary Edema; Pyruvates; Rabbits; Rats; Urea; Uremia | 1971 |
12 trial(s) available for indican and Uremia
| Article | Year |
|---|---|
Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study.
Topics: Adult; Aged; Cresols; Curcumin; Dietary Supplements; Double-Blind Method; Female; Gastrointestinal Microbiome; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Pilot Projects; Renal Dialysis; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2021 |
Long term variation of serum levels of uremic toxins in patients treated by post-dilution high volume on-line hemodiafiltration in comparison to standard low-flux bicarbonate dialysis: results from the REDERT study.
Topics: Aged; Aged, 80 and over; beta 2-Microglobulin; Bicarbonates; Biomarkers; Chromatography, Liquid; Cresols; Cross-Over Studies; Dialysis Solutions; Female; Hemodiafiltration; Humans; Indican; Italy; Male; Middle Aged; Spectrometry, Mass, Electrospray Ionization; Sulfuric Acid Esters; Tandem Mass Spectrometry; Time Factors; Treatment Outcome; Uremia | 2017 |
Adsorption of Protein-Bound Uremic Toxins Through Direct Hemoperfusion With Hexadecyl-Immobilized Cellulose Beads in Patients Undergoing Hemodialysis.
Topics: Adsorption; Aged; Blood Proteins; Cellulose; Cresols; Feasibility Studies; Female; Hemoperfusion; Humans; Indican; Indoleacetic Acids; Kidney Failure, Chronic; Male; Middle Aged; Porosity; Protein Binding; Renal Dialysis; Serum Albumin; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2018 |
Results of the HEMO Study suggest that p-cresol sulfate and indoxyl sulfate are not associated with cardiovascular outcomes.
Topics: Adult; Aged; Cardiovascular Diseases; Cresols; Female; Glutamine; Hippurates; Humans; Indican; Kidney Failure, Chronic; Longitudinal Studies; Male; Middle Aged; Renal Dialysis; Risk Factors; Serum Albumin; Sulfuric Acid Esters; Uremia | 2017 |
Shen-Shuai-Ning granule decreased serum concentrations of indoxyl sulphate in uremic patients undergoing peritoneal dialysis.
Topics: Adult; Cresols; Drugs, Chinese Herbal; Female; Humans; Indican; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Peritoneal Dialysis; Sulfuric Acid Esters; Treatment Outcome; Uremia | 2018 |
Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial.
Topics: Aged; Bifidobacterium longum; Biomarkers; Brazil; Cresols; Female; Gastrointestinal Microbiome; Humans; Hydrogen-Ion Concentration; Indican; Indoleacetic Acids; Male; Meals; Middle Aged; Probiotics; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Synbiotics; Urea; Uremia | 2019 |
The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
Topics: Adsorption; Aged; Chelating Agents; Cresols; Double-Blind Method; Female; Gastrointestinal Tract; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Renal Insufficiency, Chronic; Sevelamer; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2019 |
Limited reduction in uremic solute concentrations with increased dialysis frequency and time in the Frequent Hemodialysis Network Daily Trial.
Topics: Adult; Cresols; Female; Humans; Indican; Kidney Failure, Chronic; Male; Metabolomics; Middle Aged; Renal Dialysis; Sulfuric Acid Esters; Time Factors; Uremia | 2017 |
Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration.
Topics: Aged; beta 2-Microglobulin; Cresols; Cross-Over Studies; Cystatin C; Female; Hemodiafiltration; Humans; Indican; Male; Middle Aged; Myoglobin; Polymers; Prospective Studies; Renal Dialysis; Retinol-Binding Proteins; Serum Albumin; Sulfones; Sulfuric Acid Esters; Uremia | 2010 |
Behavior of non-protein-bound and protein-bound uremic solutes during daily hemodialysis.
Topics: Creatinine; Cresols; Cross-Over Studies; Female; Furans; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Membranes, Artificial; Middle Aged; Propionates; Protein Binding; Renal Dialysis; Solutions; Toxins, Biological; Urea; Uremia; Uric Acid | 2002 |
Elevation of circulating endothelial microparticles in patients with chronic renal failure.
Topics: Adult; Aged; Aged, 80 and over; Annexin A5; Antigens, CD; Cadherins; CD146 Antigen; Cells, Cultured; Cresols; Endothelial Cells; Female; Humans; Indican; Kidney Failure, Chronic; Male; Middle Aged; Particle Size; Renal Dialysis; Toxins, Biological; Uremia | 2006 |
Indoxyl sulfate and progression of renal failure: effects of a low-protein diet and oral sorbent on indoxyl sulfate production in uremic rats and undialyzed uremic patients.
Topics: Administration, Oral; Adsorption; Adult; Aged; Animals; Carbon; Dietary Proteins; Disease Progression; Fasting; Female; Humans; Indican; Male; Microspheres; Middle Aged; Oxides; Rats; Rats, Sprague-Dawley; Renal Dialysis; Renal Insufficiency; Uremia | 1997 |
182 other study(ies) available for indican and Uremia
| Article | Year |
|---|---|
Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake.
Topics: Animals; Binding Sites; Cell Line; Cell Line, Transformed; Dose-Response Relationship, Drug; Free Radicals; Growth Inhibitors; Humans; Kidney Tubules, Proximal; Opossums; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Rats; Toxins, Biological; Uremia | 2002 |
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
Topics: Animals; Anions; Biological Transport; Dose-Response Relationship, Drug; Female; Furans; Indican; Kidney; Kidney Failure, Chronic; Male; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Propionates; Rats; Rats, Wistar; Toxins, Biological; Tritium; Uremia; Uricosuric Agents; Xenopus laevis | 2002 |
Characterization of uremic toxin transport by organic anion transporters in the kidney.
Topics: Animals; DNA, Complementary; GABA Modulators; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Tubules, Proximal; LLC-PK1 Cells; Male; Organ Culture Techniques; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Penicillin G; Pravastatin; Rats; Rats, Sprague-Dawley; Swine; Toxins, Biological; Transfection; Uremia | 2004 |
Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.
Topics: Animals; Cell Line; Dogs; Dose-Response Relationship, Drug; Erythromycin; Furans; Indican; Liver; Male; Propionates; Rats; Rats, Wistar; Uremia | 2004 |
Improved Dialysis Removal of Protein-Bound Uraemic Toxins with a Combined Displacement and Adsorption Technique.
Topics: Adsorption; Animals; Emulsions; Humans; Indican; Rats; Renal Dialysis; Toxins, Biological; Uremia; Uremic Toxins | 2022 |
Is there an association between the plasma levels of uremic toxins from gut microbiota and anemia in patients on hemodialysis?
Topics: Anemia; Cross-Sectional Studies; Female; Gastrointestinal Microbiome; Humans; Indican; Male; Renal Dialysis; Renal Insufficiency, Chronic; Uremia; Uremic Toxins | 2022 |
Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease.
Topics: Adult; Aged; Biomarkers; Cohort Studies; Female; Glomerular Filtration Rate; Glycocalyx; Humans; Indican; Linear Models; Male; MicroRNAs; Middle Aged; Multivariate Analysis; Renal Insufficiency, Chronic; Syndecan-1; Toxins, Biological; Uremia | 2021 |
The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study.
Topics: Albumins; Biological Transport; Computer Simulation; Humans; Indican; Kidney Tubules, Proximal; Membrane Transport Proteins; Organic Anion Transport Protein 1; Toxins, Biological; Uremia | 2021 |
Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD.
Topics: Animals; Aorta; Carotid Artery Injuries; Carotid Artery Thrombosis; Culture Media; Enzyme Induction; Feedback, Physiological; Female; HEK293 Cells; Humans; Indican; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Myocytes, Smooth Muscle; Postoperative Complications; Renal Insufficiency, Chronic; Thromboplastin; Thrombosis; Tryptophan; Uremia; Vascular Surgical Procedures | 2021 |
Indoxyl sulfate in uremia: an old idea with updated concepts.
Topics: Animals; Humans; Indican; Mice; Renal Dialysis; Renal Insufficiency, Chronic; Uremia; Zebrafish | 2022 |
Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.
Topics: Animals; C-Reactive Protein; Carbazoles; Cells, Cultured; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Indican; Indoleacetic Acids; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Uremia | 2022 |
Highly sensitive simultaneous quantification of indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Furans; Humans; Indican; Pharmaceutical Preparations; Propionates; Tandem Mass Spectrometry; Uremia | 2022 |
Removal of Uremic Solutes from Dialysate by Activated Carbon.
Topics: Charcoal; Dialysis Solutions; Humans; Indican; Protein Binding; Renal Dialysis; Uremia | 2022 |
Protein-bound uremic toxins: putative modulators of calcineurin inhibitor exposure.
Topics: Calcineurin Inhibitors; Humans; Indican; Kidney Transplantation; Uremia; Uremic Toxins | 2022 |
Protein/Fiber Index Modulates Uremic Toxin Concentrations in Hemodialysis Patients.
Topics: Cresols; Dietary Fiber; Humans; Indican; Prospective Studies; Proteins; Renal Dialysis; Renal Insufficiency, Chronic; Sulfates; Sulfuric Acid Esters; Toxins, Biological; Uremia; Uremic Toxins | 2022 |
Correlation between Saliva Levels and Serum Levels of Free Uremic Toxins in Healthy Volunteers.
Topics: Chromatography, Liquid; Healthy Volunteers; Humans; Indican; Renal Dialysis; Saliva; Sulfates; Tandem Mass Spectrometry; Toxins, Biological; Tyrosine; Uremia; Uremic Toxins | 2023 |
Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment.
Topics: Humans; Indican; Indoles; Metal-Organic Frameworks; Renal Insufficiency, Chronic; Uremia; Uremic Toxins | 2023 |
Effects of N-acetyl-L-tryptophan on desorption of the protein-bound uremic toxin indoxyl sulfate and effects on uremic sarcopenia.
Topics: Humans; Indican; Sarcopenia; Tryptophan; Uremia; Uremic Toxins | 2023 |
Association between Dental Scores and Saliva Uremic Toxins.
Topics: Chromatography, Liquid; Humans; Indican; Prospective Studies; Renal Insufficiency, Chronic; Saliva; Tandem Mass Spectrometry; Toxins, Biological; Uremia; Uremic Toxins | 2023 |
Uremia and Hypoxia Independently Induce Eryptosis and Erythrocyte Redox Imbalance.
Topics: Adult; Calcium; Cytosol; Eryptosis; Erythrocytes; Female; Glutathione; Humans; Hypoxia; Indican; Male; Oxidation-Reduction; Phosphatidylserines; Reactive Oxygen Species; Uremia; Young Adult | 2019 |
Carbon Nanotube/Conducting Polymer Hybrid Nanofibers as Novel Organic Bioelectronic Interfaces for Efficient Removal of Protein-Bound Uremic Toxins.
Topics: Adsorption; Cresols; Electronics; Hippurates; Humans; Indican; Nanotubes, Carbon; Polymers; Proteins; Renal Dialysis; Toxins, Biological; Uremia | 2019 |
Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney disease.
Topics: Animals; Indican; Mice; Mice, Transgenic; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Uremia | 2020 |
CharXgen-Activated Bamboo Charcoal Encapsulated in Sodium Alginate Microsphere as the Absorbent of Uremic Toxins to Retard Kidney Function Deterioration.
Topics: Alginates; Animals; Carbon; Cell Line; Charcoal; Cresols; Disease Models, Animal; Humans; Indican; Microscopy, Electron, Scanning; Microspheres; Oxides; Rats; Renal Insufficiency, Chronic; Sasa; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2020 |
Oral Charcoal Adsorbents Attenuate Neointima Formation of Arteriovenous Fistulas.
Topics: Administration, Oral; Adsorption; Animals; Arteriovenous Shunt, Surgical; Carbon; Collagen; Disease Models, Animal; Graft Occlusion, Vascular; Indican; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Neointima; Oxides; Renal Insufficiency, Chronic; Toxins, Biological; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Uremia; Vascular Patency | 2020 |
Factors of microinflammation in non-diabetic chronic kidney disease: a pilot study.
Topics: Bacterial Translocation; Biomarkers; C-Reactive Protein; Female; Gastrointestinal Microbiome; Humans; Indican; Indoleacetic Acids; Inflammation; Kidney Function Tests; Male; Oxidative Stress; Patient Acuity; Pilot Projects; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremia | 2020 |
Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney disease.
Topics: Feces; Gastrointestinal Microbiome; Humans; Indican; Renal Insufficiency, Chronic; Toxins, Biological; Uremia | 2020 |
Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease.
Topics: Animals; Aristolochic Acids; Cresols; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Indican; JNK Mitogen-Activated Protein Kinases; Kidney Tubules; Mice, Inbred C57BL; Propolis; Renal Insufficiency, Chronic; Signal Transduction; Smad2 Protein; Smad3 Protein; Sulfuric Acid Esters; Transforming Growth Factor beta; Uremia | 2020 |
Neurobehavioral effects of uremic toxin-indoxyl sulfate in the rat model.
Topics: Animals; Central Nervous System; Dopamine; Indican; Kidney; Locomotion; Male; Maze Learning; Models, Animal; Nervous System Diseases; Norepinephrine; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Serotonin; Spatial Memory; Toxins, Biological; Uremia | 2020 |
Indoxyl Sulfate-Mediated Metabolic Alteration of Transcriptome Signatures in Monocytes of Patients with End-Stage Renal Disease (ESRD).
Topics: Aged; Case-Control Studies; Energy Metabolism; Female; Gene Expression Profiling; Gene Regulatory Networks; Humans; Indican; Kidney Failure, Chronic; Male; Middle Aged; Monocytes; Protein Interaction Maps; Toxins, Biological; Transcriptome; Up-Regulation; Uremia | 2020 |
CREB/ATF3 signaling mediates indoxyl sulfate-induced vascular smooth muscle cell proliferation and neointimal formation in uremia.
Topics: Activating Transcription Factor 3; Animals; Cell Proliferation; Cells, Cultured; Humans; Indican; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Rats; Uremia | 2020 |
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Topics: Cells, Cultured; Cellular Senescence; Chronic Kidney Disease-Mineral and Bone Disorder; Cresols; Healthy Volunteers; Humans; Indican; Mesenchymal Stem Cells; Osteogenesis; Primary Cell Culture; Renal Insufficiency, Chronic; Toxins, Biological; Uremia | 2021 |
Free p-cresyl sulfate shows the highest association with cardiovascular outcome in chronic kidney disease.
Topics: Cresols; Humans; Indican; Renal Insufficiency, Chronic; Sulfates; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2021 |
Associations among total p-cresylsulfate, indoxyl sulfate and hippuric acid levels with hemodialysis quality indicators in maintenance hemodialysis patients.
Topics: Cresols; Hippurates; Humans; Indican; Quality Indicators, Health Care; Renal Dialysis; Sulfuric Acid Esters; Uremia | 2021 |
pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro.
Topics: Calorimetry; Circular Dichroism; Cresols; Humans; Hydrogen-Ion Concentration; Indican; Indoleacetic Acids; Protein Binding; Protein Conformation; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin, Human; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2021 |
Effects of Uremic Toxins on the Binding of Aripiprazole to Human Serum Albumin.
Topics: Antipsychotic Agents; Aripiprazole; Binding Sites; Cresols; Humans; Indican; Indoleacetic Acids; Oleic Acid; Protein Binding; Serum Albumin, Human; Sulfuric Acid Esters; Uremia | 2021 |
Analyzing the Long Time-Scale Dynamics of Uremic Toxins Bound to Sudlow Site II in Human Serum Albumin.
Topics: Humans; Indican; Protein Binding; Renal Dialysis; Serum Albumin, Human; Toxins, Biological; Uremia | 2021 |
Uremic endothelial-derived extracellular vesicles: Mechanisms of formation and their role in cell adhesion, cell migration, inflammation, and oxidative stress.
Topics: Cell Adhesion; Cell Line; Cell Movement; Cresols; Endothelial Cells; Extracellular Vesicles; Humans; Indican; Inflammation Mediators; Oxidative Stress; Phosphates; Signal Transduction; Sulfuric Acid Esters; Uremia; Vascular Cell Adhesion Molecule-1 | 2021 |
[Purple urine bag syndrome (PUBS): about two cases at the Regional University Hospital Center (CHUR) of Ouahigouya].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bacteria; Brain Diseases; Burkina Faso; Catheters, Indwelling; Female; Humans; Indican; Syndrome; Uremia; Urinary Catheterization; Urinary Tract Infections; Urine | 2021 |
Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress.
Topics: Aged; Bacteria; Gastrointestinal Microbiome; Humans; Indican; Inflammation; Interleukin-6; Malondialdehyde; Middle Aged; Oxidative Stress; Renal Dialysis; Renal Insufficiency, Chronic; Sarcopenia; Uremia; Uremic Toxins | 2021 |
Circulating
Topics: Alkaline Phosphatase; Biomarkers; Bone and Bones; Bone Diseases; Cresols; Fractures, Bone; Humans; Indican; Middle Aged; Minerals; Renal Dialysis; Renal Insufficiency, Chronic; Sulfates; Sulfuric Acid Esters; Toxins, Biological; Uremia; Uremic Toxins | 2021 |
Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.
Topics: Biological Transport; Cell Line; Cell Survival; Chemokine CCL2; Cresols; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Indican; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Probenecid; Sulfuric Acid Esters; Time Factors; Up-Regulation; Uremia | 2017 |
Exploring binding characteristics and the related competition of different protein-bound uremic toxins.
Topics: Binding, Competitive; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Hippurates; Humans; Indican; Indoleacetic Acids; Protein Binding; Protein Processing, Post-Translational; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin; Sulfuric Acid Esters; Tandem Mass Spectrometry; Toxins, Biological; Uremia | 2017 |
The Uremic Toxin Indoxyl Sulfate Accelerates Thrombotic Response after Vascular Injury in Animal Models.
Topics: Animals; Blood Coagulation; Electric Stimulation; Hematologic Tests; Indican; Lasers; Male; Mesentery; Mice, Inbred C57BL; Platelet Aggregation; Rats, Wistar; Thrombosis; Toxins, Biological; Uremia; Vascular System Injuries | 2017 |
Carbon Adsorbents With Dual Porosity for Efficient Removal of Uremic Toxins and Cytokines from Human Plasma.
Topics: Adsorption; beta 2-Microglobulin; Carbon; Cytokines; Hippurates; Humans; Indican; Porosity; Sorption Detoxification; Toxins, Biological; Uremia | 2017 |
p-cresol sulfate and indoxyl sulfate: some clouds are gathering in the uremic toxin sky.
Topics: Cresols; Humans; Indican; Renal Dialysis; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2017 |
Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy.
Topics: Activating Transcription Factor 3; Animals; Cardiomyopathies; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Indican; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Rats; Receptor, Cannabinoid, CB1; Signal Transduction; Up-Regulation; Uremia | 2018 |
Impact of the Oral Adsorbent AST-120 on Organ-Specific Accumulation of Uremic Toxins: LC-MS/MS and MS Imaging Techniques.
Topics: Administration, Oral; Adsorption; Animals; Carbon; Chromatography, Liquid; Cresols; Indican; Kidney Failure, Chronic; Male; Mice, Inbred C57BL; Oxides; Sulfuric Acid Esters; Tandem Mass Spectrometry; Toxins, Biological; Uremia | 2017 |
Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Indican; Kynurenine; Male; Metabolomics; Middle Aged; Pattern Recognition, Automated; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Signal Transduction; Thromboplastin; Thrombosis; Uremia; Vascular System Injuries | 2018 |
The double-edged sword of endoplasmic reticulum stress in uremic sarcopenia through myogenesis perturbation.
Topics: Animals; Cell Differentiation; Cell Line; Endoplasmic Reticulum Stress; Indican; Mice; Muscle Development; Myoblasts; MyoD Protein; Proto-Oncogene Proteins c-akt; Sarcopenia; Unfolded Protein Response; Uremia | 2018 |
Stabilization of cell-cell junctions by active vitamin D ameliorates uraemia-induced loss of human endothelial barrier function.
Topics: Actins; Adult; Aged; Antigens, CD; Cadherins; Cell Adhesion; Cell Movement; Cells, Cultured; Cresols; Endothelial Cells; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Indican; Intercellular Junctions; Male; Middle Aged; Thrombin; Uremia; Vitamin D; Young Adult | 2019 |
Indoxyl Sulfate, a Uremic Toxin, Stimulates Reactive Oxygen Species Production and Erythrocyte Cell Death Supposedly by an Organic Anion Transporter 2 (OAT2) and NADPH Oxidase Activity-Dependent Pathways.
Topics: Adult; Eryptosis; Erythrocytes; Female; Humans; Indican; Male; NADPH Oxidases; Organic Anion Transporters, Sodium-Independent; Reactive Oxygen Species; Renal Dialysis; Signal Transduction; Toxins, Biological; Uremia; Young Adult | 2018 |
Indoxyl glucuronide, a protein-bound uremic toxin, inhibits hypoxia-inducible factor‒dependent erythropoietin expression through activation of aryl hydrocarbon receptor.
Topics: Cell Survival; Cytochrome P-450 CYP1A1; Erythropoietin; Gene Expression Regulation; Glucuronates; Hep G2 Cells; Humans; Indican; Indoles; Protein Binding; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Signal Transduction; Transcriptional Activation; Uremia | 2018 |
Association of Uremic Toxins and Inflammatory Markers with Physical Performance in Dialysis Patients.
Topics: Adult; Aged; Arginine; beta 2-Microglobulin; Biomarkers; C-Reactive Protein; Female; Hand Strength; Humans; Indican; Inflammation; Insulin-Like Growth Factor I; Interleukin-6; Male; Middle Aged; Myostatin; Physical Functional Performance; Renal Dialysis; Toxins, Biological; Urea; Uremia; Walking | 2018 |
Uremia Impacts VE-Cadherin and ZO-1 Expression in Human Endothelial Cell-to-Cell Junctions.
Topics: Antigens, CD; Cadherins; Cell Line; Cresols; Endothelial Cells; Female; Humans; Indican; Intercellular Junctions; Male; Middle Aged; Phosphates; Renal Artery; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia; Zonula Occludens-1 Protein | 2018 |
Increasing the removal of protein-bound uremic toxins by liposome-supported hemodialysis.
Topics: Animals; Cresols; Dialysis Solutions; Equipment Design; Hippurates; Indican; Kidney Failure, Chronic; Liposomes; Male; Rats, Sprague-Dawley; Renal Dialysis; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2019 |
Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease.
Topics: Adult; Arterial Pressure; Cardiac Output; Cresols; Exercise; Glucuronides; Heart Diseases; Heart Rate; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2018 |
Uremic Toxins Activate Macrophages.
Topics: Humans; Indican; Macrophage Activation; Macrophages; Signal Transduction; Toxins, Biological; Uremia | 2019 |
Evolution of protein-bound uremic toxins indoxyl sulphate and p-cresyl sulphate in acute kidney injury.
Topics: Acute Kidney Injury; Aged; Belgium; Correlation of Data; Creatinine; Cresols; Female; Humans; Indican; Male; Middle Aged; Sepsis; Sulfuric Acid Esters; Time Factors; Uremia | 2019 |
Improved dialysis removal of protein-bound uremic toxins by salvianolic acids.
Topics: Alkenes; Animals; Binding, Competitive; Cresols; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Indican; Male; Microdialysis; Polyphenols; Protein Binding; Proteins; Rats, Sprague-Dawley; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2019 |
Amelioration of Uremic Toxin Indoxyl Sulfate-Induced Osteoblastic Calcification by SET Domain Containing Lysine Methyltransferase 7/9 Protein.
Topics: Calcification, Physiologic; Humans; Indican; Lysine; Methyltransferases; Osteoblasts; Uremia | 2019 |
AST-120, an Adsorbent of Uremic Toxins, Improves the Pathophysiology of Heart Failure in Conscious Dogs.
Topics: Adsorption; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbon; Cardio-Renal Syndrome; Consciousness; Disease Models, Animal; Dogs; Fibrosis; Heart Failure; Hemodynamics; Indican; Kidney Diseases; Mitochondria, Heart; Myocardium; Oxides; Signal Transduction; Sorption Detoxification; Uremia; Ventricular Function, Left | 2019 |
Effect of Indoxyl Sulfate on the Repair and Intactness of Intestinal Epithelial Cells: Role of Reactive Oxygen Species' Release.
Topics: Animals; Antioxidants; Carbon; Cell Movement; Cell Survival; Connexin 43; Epithelial Cells; Humans; Indican; Intestines; NF-E2-Related Factor 2; Oxidative Stress; Oxides; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Uremia | 2019 |
Indoxyl Sulfate-Induced Extracellular Vesicles Released from Endothelial Cells Stimulate Vascular Smooth Muscle Cell Proliferation by Inducing Transforming Growth Factor-Beta Production.
Topics: Cell Proliferation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Extracellular Vesicles; Human Umbilical Vein Endothelial Cells; Humans; Indican; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; p38 Mitogen-Activated Protein Kinases; Paracrine Communication; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Uremia | 2019 |
Klotho restrain RIG-1/NF-κB signaling activation and monocyte inflammatory factor release under uremic condition.
Topics: Adult; Animals; Blotting, Western; DEAD Box Protein 58; Female; Glucuronidase; Humans; Indican; Inflammation; Interleukin-6; Kidney; Klotho Proteins; Male; Mice; Mice, Inbred BALB C; Middle Aged; Monocytes; NF-kappa B; Receptors, Immunologic; Renal Insufficiency, Chronic; Signal Transduction; THP-1 Cells; Tumor Necrosis Factor-alpha; Uremia | 2019 |
Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes.
Topics: Biological Transport; Cresols; Erythrocytes; Hippurates; Humans; Indican; Indoleacetic Acids; Protein Binding; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremia | 2019 |
Development and validation of a UHPLC-MS/MS method for measurement of a gut-derived uremic toxin panel in human serum: An application in patients with kidney disease.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cresols; Hippurates; Humans; Hydrogen-Ion Concentration; Indican; Kidney Diseases; Kynurenic Acid; Quality Control; Reproducibility of Results; Risk Factors; Solvents; Sulfuric Acid Esters; Tandem Mass Spectrometry; Time Factors; Uremia | 2019 |
A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients.
Topics: Adsorption; Blood Cell Count; Charcoal; Cresols; Humans; Indican; Phenylacetates; Povidone; Renal Dialysis; Renal Insufficiency; Sulfuric Acid Esters; Uremia | 2019 |
Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB.
Topics: Animals; Cell Line; Down-Regulation; Humans; Indican; Kidney; Male; NF-E2-Related Factor 2; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Uremia | 2013 |
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia.
Topics: Animals; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Indican; Mice; p300-CBP Transcription Factors; Rats; Renal Insufficiency, Chronic; RNA, Messenger; Signal Transduction; Uremia | 2013 |
Safety issues related to fractionated plasma separation, adsorption, and dialysis.
Topics: Cresols; Humans; Indican; Phenylacetates; Plasmapheresis; Renal Dialysis; Sulfuric Acid Esters; Uremia | 2013 |
Protein-bound uremic toxins stimulate crosstalk between leukocytes and vessel wall.
Topics: Animals; Capillary Permeability; Cell Adhesion; Cell Communication; Cresols; Endothelium, Vascular; Female; Glucuronides; Hemodynamics; Indican; Leukocyte Rolling; Leukocytes; Lipopolysaccharides; Peritoneum; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Respiratory Burst; Sulfuric Acid Esters; Uremia | 2013 |
Uremic toxin development in living kidney donors: a longitudinal study.
Topics: Adult; Biomarkers; Cresols; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Incidence; Indican; Kidney; Kidney Transplantation; Living Donors; Longitudinal Studies; Male; Middle Aged; Nephrectomy; Predictive Value of Tests; Prospective Studies; Sulfuric Acid Esters; Uremia | 2014 |
Does the adequacy parameter Kt/V(urea) reflect uremic toxin concentrations in hemodialysis patients?
Topics: Aged; Aged, 80 and over; beta 2-Microglobulin; Biomarkers; Creatinine; Cresols; Diabetes Mellitus; Female; Furans; Glucuronides; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Multivariate Analysis; Propionates; Renal Dialysis; Sulfuric Acid Esters; Treatment Outcome; Urea; Uremia; Uric Acid | 2013 |
Indoxyl sulfate promotes apoptosis in cultured osteoblast cells.
Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Differentiation; Cell Line; Cell Survival; Collagen Type I; Dose-Response Relationship, Drug; Flow Cytometry; Free Radicals; Indican; Mice; Organic Anion Transporters; Osteoblasts; Osteogenesis; Osteonectin; Oxidative Stress; Uremia | 2013 |
Uremic toxin indoxyl 3-sulfate regulates the differentiation of Th2 but not of Th1 cells to lessen allergic asthma.
Topics: Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; Benzoflavones; Bronchoalveolar Lavage Fluid; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Immunoglobulin E; Indican; Interleukin-4; Male; Mice; Mice, Inbred C57BL; Ovalbumin; Phosphorylation; Pulmonary Eosinophilia; Receptors, Aryl Hydrocarbon; STAT5 Transcription Factor; STAT6 Transcription Factor; Th1 Cells; Th2 Cells; Uremia | 2014 |
Binding affinity and capacity for the uremic toxin indoxyl sulfate.
Topics: Blood Proteins; Humans; Indican; Models, Biological; Osmolar Concentration; Protein Binding; Sodium Chloride; Temperature; Toxins, Biological; Uremia | 2014 |
Uremic toxins impair human bone marrow-derived mesenchymal stem cells functionality in vitro.
Topics: Apoptosis; Cell Adhesion; Cell Membrane; Cell Proliferation; Cell Survival; Cells, Cultured; Cresols; Humans; Indican; Mesenchymal Stem Cells; Uremia | 2014 |
The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation.
Topics: Amidines; Antioxidants; Atherosclerosis; Copper; Hemin; Humans; Hydrogen Peroxide; Indican; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Oxidation-Reduction; Oxidative Stress; Peroxidase; Quinazolines; Renal Insufficiency, Chronic; Uremia | 2014 |
An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis.
Topics: Absorption; Charcoal; Cresols; Equipment Design; Equipment Failure Analysis; Hemofiltration; Humans; Indican; Interleukin-6; Materials Testing; Membranes, Artificial; Pilot Projects; Renal Dialysis; Sulfuric Acid Esters; Uremia | 2014 |
Effects of AST-120 on blood concentrations of protein-bound uremic toxins and biomarkers of cardiovascular risk in chronic dialysis patients.
Topics: Adsorption; Adult; Biomarkers; Carbon; Cardiovascular Diseases; Cresols; Cytokine TWEAK; Female; Humans; Indican; Interleukin-6; Kidney Failure, Chronic; Male; Malondialdehyde; Middle Aged; Oxides; Protein Binding; Renal Dialysis; Risk Factors; Sulfuric Acid Esters; Tumor Necrosis Factors; Uremia | 2014 |
Protein-bound uremic toxins, inflammation and oxidative stress: a cross-sectional study in stage 3-4 chronic kidney disease.
Topics: Aged; Antioxidants; Biomarkers; Blood Proteins; Cardiovascular Diseases; Cresols; Cross-Sectional Studies; Female; Humans; Indican; Inflammation; Interleukin-6; Male; Middle Aged; Oxidative Stress; Renal Insufficiency, Chronic; Risk Reduction Behavior; Sulfuric Acid Esters; Toxins, Biological; Uremia; Vascular Stiffness | 2014 |
Differential effects of indoxyl sulfate and inorganic phosphate in a murine cerebral endothelial cell line (bEnd.3).
Topics: Animals; Antioxidants; Azoles; Biopterins; Cell Line; Cell Survival; Cerebral Cortex; Endothelium, Vascular; Enzyme Inhibitors; Indican; Isoindoles; Mice; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type III; Organoselenium Compounds; Oxidative Stress; Phosphates; Reactive Oxygen Species; Superoxides; Up-Regulation; Uremia | 2014 |
Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins.
Topics: Benzyl Alcohol; Cresols; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Hippurates; Humans; Indican; Microsomes, Liver; Toxins, Biological; Uremia | 2014 |
Uremic toxicity and sclerostin in chronic kidney disease patients.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aortography; Arteriosclerosis; beta 2-Microglobulin; Biomarkers; Bone Morphogenetic Proteins; Calcinosis; Cresols; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Follow-Up Studies; Genetic Markers; Humans; Indican; Inflammation; Male; Middle Aged; Pulse Wave Analysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Survival Analysis; Tomography, Spiral Computed; Uremia; Vascular Stiffness | 2014 |
Uremic toxins enhance statin-induced cytotoxicity in differentiated human rhabdomyosarcoma cells.
Topics: Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Survival; Drug Synergism; Furans; Hippurates; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indican; Indoleacetic Acids; Pravastatin; Propionates; Rhabdomyosarcoma; Simvastatin; Toxins, Biological; Uremia | 2014 |
Effect of uraemia on endothelial cell damage is mediated by the integrin linked kinase pathway.
Topics: Cresols; Human Umbilical Vein Endothelial Cells; Humans; Indican; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Uremia | 2015 |
Functional genomic analysis identifies indoxyl sulfate as a major, poorly dialyzable uremic toxin in end-stage renal disease.
Topics: Adult; Aged; Animals; Cell Line; Chromatography, High Pressure Liquid; Culture Media; Female; Gene Expression Regulation; Humans; Indican; Kidney Failure, Chronic; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Plasma; Probenecid; Renal Dialysis; Swine; Uremia | 2015 |
The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia.
Topics: Adult; Female; Humans; Indican; Male; Middle Aged; Protein Stability; Receptors, Aryl Hydrocarbon; Thromboplastin; Thrombosis; Uremia | 2016 |
The Role of Liver in Determining Serum Colon-Derived Uremic Solutes.
Topics: Aged; Animals; Cohort Studies; Colon; Cresols; Disease Models, Animal; Female; Gastrointestinal Tract; Humans; Indican; Kidney; Linear Models; Liver; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Treatment Outcome; Uremia | 2015 |
Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients.
Topics: Aged; Biomarkers; Carbon; Cresols; Dinoprost; Female; Humans; Indican; Male; Middle Aged; Oxidative Stress; Oxides; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2015 |
Deleterious vascular effects of indoxyl sulfate and reversal by oral adsorbent AST-120.
Topics: Administration, Oral; Adsorption; Animals; Aorta; Apolipoproteins E; Blood Pressure; Carbon; Cardiovascular Diseases; Cell Survival; Echocardiography; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Indican; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxides; Pulse Wave Analysis; Renal Insufficiency, Chronic; Uremia; Vascular Cell Adhesion Molecule-1 | 2015 |
Exploring Protein Binding of Uremic Toxins in Patients with Different Stages of Chronic Kidney Disease and during Hemodialysis.
Topics: Aged; Aged, 80 and over; Cresols; Cross-Sectional Studies; Female; Glucuronides; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Protein Binding; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin; Severity of Illness Index; Sulfuric Acid Esters; Uremia | 2015 |
Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction.
Topics: Animals; Atrial Fibrillation; Biomarkers; Carbon; Cardiac Pacing, Artificial; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Fibroblasts; Fibrosis; Indican; Inflammation Mediators; Kidney; Male; Myocardium; Nephrectomy; Oxidative Stress; Oxides; Rats, Sprague-Dawley; Risk Factors; Signal Transduction; Time Factors; Uremia | 2015 |
Indolic uremic solutes enhance procoagulant activity of red blood cells through phosphatidylserine exposure and microparticle release.
Topics: Anticoagulants; Blood Coagulation; Calcium; Cell-Derived Microparticles; Cytosol; Erythrocytes; Factor Xa; Female; Flow Cytometry; Humans; Indican; Indoleacetic Acids; Indoles; Male; Phosphatidylserines; Thromboplastin; Thrombosis; Uremia; Young Adult | 2015 |
The uremic toxin indoxyl sulfate exacerbates reactive oxygen species production and inflammation in 3T3-L1 adipose cells.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Indican; Inflammation; Interleukin-6; Mice; NADPH Oxidases; Oxidative Stress; Reactive Oxygen Species; Renal Insufficiency, Chronic; Toxins, Biological; Tumor Necrosis Factor-alpha; Uremia | 2016 |
Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway.
Topics: Acute Kidney Injury; Aged; Animals; Biomarkers; Cells, Cultured; Disease Models, Animal; E-Selectin; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Indican; Interleukin-1beta; Kidney; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Oxidative Stress; Poisons; Reperfusion Injury; Up-Regulation; Uremia | 2016 |
Indoxyl sulfate suppresses endothelial progenitor cell-mediated neovascularization.
Topics: Angiogenic Proteins; Animals; Bone Marrow Transplantation; Carbon; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothelial Progenitor Cells; Gene Expression Regulation; Hindlimb; Humans; Indican; Inflammation Mediators; Ischemia; Male; Mice, Inbred C57BL; Muscle, Skeletal; Neovascularization, Physiologic; Nephrectomy; Oxides; Regional Blood Flow; Signal Transduction; Time Factors; Transfection; Up-Regulation; Uremia | 2016 |
The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes.
Topics: Adult; Aged; Cells, Cultured; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Female; Hepatocytes; Humans; Indican; Indoleacetic Acids; Male; Omeprazole; Renal Insufficiency, Chronic; RNA, Messenger; Uremia | 2016 |
Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1.
Topics: Animals; Antioxidants; Cell Division; Cell Line; Cytokines; Disease Models, Animal; Gene Expression Regulation; Indican; Male; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Myoblasts; Myostatin; Nephrectomy; Organ Size; Organic Anion Transporters; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Aryl Hydrocarbon; Sarcopenia; SKP Cullin F-Box Protein Ligases; Superoxides; Uremia; Weight Loss | 2016 |
Intestinal microbiota in pediatric patients with end stage renal disease: a Midwest Pediatric Nephrology Consortium study.
Topics: Actinobacteria; Adolescent; Bacterial Load; Bacteroidetes; C-Reactive Protein; Child; Child, Preschool; Cresols; Feces; Female; Firmicutes; Gastrointestinal Microbiome; Humans; Indican; Intestines; Kidney Failure, Chronic; Kidney Transplantation; Lactic Acid; Male; Peritoneal Dialysis; Proteobacteria; RNA, Ribosomal, 16S; Sulfuric Acid Esters; Uremia; Verrucomicrobia | 2016 |
Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease.
Topics: Animals; Disease Models, Animal; Indican; Male; Mice; Muscle, Skeletal; Renal Insufficiency, Chronic; Sarcopenia; Uremia | 2016 |
Microbial Modulation of a Uremic Toxin.
Topics: Animals; Bacteria; Bacterial Toxins; Biological Evolution; Cardiovascular Diseases; Diet; Gastrointestinal Microbiome; Humans; Indican; Kidney; Liver; Symbiosis; Tryptophanase; Uremia | 2016 |
Manipulating the gut microbiome to decrease uremic toxins.
Topics: Animals; Bacteroides; Gastrointestinal Microbiome; Gastrointestinal Tract; Genotype; Humans; Indican; Mutation; Phenotype; Uremia | 2017 |
Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats.
Topics: Acute Disease; Animals; Antineoplastic Agents; Antiporters; Carbon; Catecholamine Plasma Membrane Transport Proteins; Cisplatin; Gene Expression Regulation; Indican; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxides; Rats; Rats, Sprague-Dawley; RNA, Messenger; Uremia | 2008 |
Why do patients on peritoneal dialysis have low blood levels of protein-bound solutes?
Topics: Cresols; Humans; Indican; Kidney Failure, Chronic; Peritoneal Dialysis; Renal Dialysis; Sulfuric Acid Esters; Uremia | 2009 |
An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats.
Topics: Animals; Carbon; Cellular Senescence; Glucuronidase; Immunohistochemistry; Indican; Kidney; Klotho Proteins; Male; Mutation; Oxides; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Time Factors; Uremia | 2010 |
HPLC study of uremic fluids related to optical dialysis adequacy monitoring.
Topics: Aged; Aged, 80 and over; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Creatinine; Dialysis Solutions; Female; Hippurates; Humans; Indican; Male; Middle Aged; Renal Dialysis; Spectrophotometry, Ultraviolet; Urea; Uremia; Uric Acid | 2010 |
Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress.
Topics: Acetophenones; Animals; Carbon; Cell Hypoxia; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Humans; Indican; Indoles; Kidney Failure, Chronic; Kidney Tubules, Proximal; Male; NADPH Oxidases; Nephrectomy; Ouabain; Oxidative Stress; Oxides; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Time Factors; Uremia | 2010 |
Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats.
Topics: Animals; Aorta; Aortic Diseases; beta-Galactosidase; Calcinosis; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Hypertension; Indican; Rats; Rats, Inbred Dahl; Retinoblastoma Protein; Tumor Suppressor Protein p53; Uremia | 2010 |
Inhibitory effects of uraemic toxins 3-indoxyl sulfate and p-cresol on losartan metabolism in vitro.
Topics: Angiotensin II Type 1 Receptor Blockers; Aryl Hydrocarbon Hydroxylases; Cresols; Cytochrome P-450 CYP2C9; Humans; Imidazoles; In Vitro Techniques; Indican; Kidney Failure, Chronic; Losartan; Microsomes, Liver; Renal Dialysis; Tetrazoles; Uremia | 2010 |
Metabolomic search for uremic toxins as indicators of the effect of an oral sorbent AST-120 by liquid chromatography/tandem mass spectrometry.
Topics: Adsorption; Animals; Carbon; Chromatography, Liquid; Hippurates; Indican; Kidney Failure, Chronic; Male; Metabolomics; Oxides; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Toxins, Biological; Uremia | 2010 |
p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease.
Topics: Aged; Biomarkers; Cohort Studies; Creatinine; Cresols; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Indican; Kidney Failure, Chronic; Kidney Function Tests; Male; Prognosis; Prospective Studies; Risk Factors; Sulfuric Acid Esters; Survival Rate; Uremia | 2011 |
Role of oxidative stress and indoxyl sulfate in progression of cardiovascular disease in chronic kidney disease.
Topics: Animals; Carbon; Cardiovascular Diseases; Chronic Disease; Disease Progression; Drug Delivery Systems; Humans; Indican; Kidney Diseases; Oxidative Stress; Oxides; Uremia | 2011 |
New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Chronic Disease; Humans; Indican; Kidney Diseases; Oxidants; Oxidation-Reduction; Oxidative Stress; Uremia | 2011 |
Role of indoxyl sulfate in the progression of chronic kidney disease and cardiovascular disease: experimental and clinical effects of oral sorbent AST-120.
Topics: Animals; Carbon; Cardiovascular Diseases; Chronic Disease; Disease Progression; Humans; Indican; Kidney Diseases; Oxidative Stress; Oxides; Protein Binding; Rats; Uremia | 2011 |
Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).
Topics: Animals; Cell Membrane Permeability; Fluorescent Dyes; Indican; Kynurenine; Metabolome; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Oocytes; Organic Anion Transport Protein 1; Pantothenic Acid; Pyridoxic Acid; Sulfuric Acid Esters; Uremia; Urinalysis; Xanthurenates; Xenopus | 2011 |
Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation.
Topics: Cell Movement; Cells, Cultured; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Indican; Myosin Light Chains; Nitric Oxide; Nitric Oxide Donors; S-Nitroso-N-Acetylpenicillamine; Uremia | 2011 |
Determination of uremic solutes in biological fluids of chronic kidney disease patients by HPLC assay.
Topics: Aged; Chromatography, High Pressure Liquid; Cresols; Female; Humans; Indican; Indoleacetic Acids; Kidney Failure, Chronic; Male; Middle Aged; Phenol; Phenols; Sulfuric Acid Esters; Uremia | 2011 |
Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner.
Topics: Animals; Blotting, Western; Cobalt; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Gene Expression Regulation; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1; Indican; Indoles; Kidney Failure, Chronic; Luciferases; Oxygen; Rats; Uremia | 2011 |
Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.
Topics: Animals; Azacitidine; Cell Line; CpG Islands; Cresols; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression; Glucuronidase; Humans; Indican; Kidney; Klotho Proteins; Mice; Protein Binding; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2012 |
Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition.
Topics: Angiotensinogen; Animals; Cresols; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression Regulation; Indican; Kidney; Kidney Failure, Chronic; Kidney Tubules; Losartan; Male; Mice; Models, Biological; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Snail Family Transcription Factors; Sulfuric Acid Esters; Transcription Factors; Transforming Growth Factor beta1; Uremia | 2012 |
Interaction between two sulfate-conjugated uremic toxins, p-cresyl sulfate and indoxyl sulfate, during binding with human serum albumin.
Topics: Binding Sites; Biological Transport; Cresols; Humans; Immunotoxins; Indican; Kidney Failure, Chronic; Mutation; Protein Binding; Serum Albumin; Sulfates; Sulfuric Acid Esters; Ultrafiltration; Uremia | 2012 |
Antagonists of organic anion transporters 1 and 3 ameliorate adverse cardiac remodelling induced by uremic toxin indoxyl sulfate.
Topics: Animals; Cells, Cultured; Cilastatin; Fibroblasts; Indican; Myocytes, Cardiac; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Probenecid; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Uremia; Uricosuric Agents; Ventricular Remodeling | 2012 |
High correlation between clearance of renal protein-bound uremic toxins (indoxyl sulfate and p-cresyl sulfate) and renal water-soluble toxins in peritoneal dialysis patients.
Topics: Cresols; Cross-Sectional Studies; Female; Humans; Indican; Kidney; Male; Metabolic Clearance Rate; Middle Aged; Peritoneal Dialysis; Peritoneal Dialysis, Continuous Ambulatory; Sulfuric Acid Esters; Toxins, Biological; Uremia; Water | 2012 |
Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Fibrosis; Gene Expression; Humans; Indican; Kidney Tubules, Proximal; Male; Nephrectomy; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; STAT3 Transcription Factor; Uremia | 2012 |
Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy.
Topics: Adult; Aged; Biomarkers; Cardiomyopathy, Dilated; Disease Progression; Female; Heart Failure; Humans; Indican; Kaplan-Meier Estimate; Male; Middle Aged; Natriuretic Peptide, Brain; Predictive Value of Tests; Prognosis; Renal Insufficiency, Chronic; Risk Factors; Stroke Volume; Ultrasonography; Uremia | 2013 |
Do only small uremic toxins, chromophores, contribute to the online dialysis dose monitoring by UV absorbance?
Topics: Absorption; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Dialysis Solutions; Dose-Response Relationship, Drug; Female; Humans; Indican; Male; Monitoring, Physiologic; Renal Dialysis; Ultraviolet Rays; Uremia; Uric Acid | 2012 |
Uremia suppresses immune signal-induced CYP27B1 expression in human monocytes.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Cell Line, Tumor; Cresols; Cytokines; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Humans; Indican; Monocytes; Serum; Signal Transduction; Sulfuric Acid Esters; Up-Regulation; Uremia | 2012 |
Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure.
Topics: Animals; Aorta; Apoptosis; Blotting, Western; Cell Line; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Glucose; Glucose Transporter Type 1; Hyperplasia; Hypertrophy; Immunohistochemistry; Indican; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nephrectomy; Phloretin; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Renal Insufficiency; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Up-Regulation; Uremia | 2013 |
Uremic serum and solutes increase post-vascular interventional thrombotic risk through altered stability of smooth muscle cell tissue factor.
Topics: Adult; Aged; Cell Line; Coronary Vessels; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Indican; Indoleacetic Acids; Kidney Failure, Chronic; Male; Middle Aged; Myocytes, Smooth Muscle; Renal Dialysis; Risk Factors; Serum; Stents; Thromboplastin; Thrombosis; Ubiquitination; Uremia | 2013 |
A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients.
Topics: Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Female; Furans; Glucuronides; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Propionates; Renal Insufficiency, Chronic; Severity of Illness Index; Sulfuric Acid Esters; Tandem Mass Spectrometry; Uremia; Uric Acid | 2013 |
Removal of protein-bound, hydrophobic uremic toxins by a combined fractionated plasma separation and adsorption technique.
Topics: Adsorption; Blood Proteins; Cresols; Humans; Indican; Phenylacetates; Pilot Projects; Plasmapheresis; Protein Binding; Renal Dialysis; Sulfuric Acid Esters; Uremia | 2013 |
Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain.
Topics: Animals; Antimetabolites; Biological Transport; Blood-Brain Barrier; Brain; Capillaries; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; GABA Agonists; Homovanillic Acid; Indican; Male; Microinjections; Neurotransmitter Agents; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Uremia; Xenopus laevis | 2002 |
Effects of the oral adsorbent AST-120 on tryptophan metabolism in uremic patients.
Topics: Administration, Oral; Adsorption; Blood Proteins; Carbon; Dialysis; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Indican; Kidney Failure, Chronic; Microspheres; Middle Aged; Nutrition Disorders; Nutritional Status; Oxides; Protein Binding; Serum Albumin, Bovine; Tryptophan; Uremia | 2003 |
Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells.
Topics: Anions; Cells, Cultured; Free Radicals; Gene Expression; Humans; Indican; Indoleacetic Acids; Kidney Failure, Chronic; Kidney Tubules, Proximal; NF-kappa B; Oxidative Stress; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Signal Transduction; Toxins, Biological; Up-Regulation; Uremia | 2003 |
[On the diagnosis of uremia on the cadaver].
Topics: Cadaver; Humans; Indican; Uremia; Urologic Diseases | 1960 |
The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair.
Topics: Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cresols; Endothelium, Vascular; Humans; Indican; Umbilical Veins; Uremia; Wound Healing | 2004 |
Beneficial effects of Bifidobacteria in a gastroresistant seamless capsule on hyperhomocysteinemia in hemodialysis patients.
Topics: Bifidobacterium; Capsules; Colony Count, Microbial; Escherichia coli; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Indican; Intestines; Probiotics; Renal Dialysis; Uremia | 2005 |
Oxidative stress, advanced glycation end product, and coronary artery calcification in hemodialysis patients.
Topics: Aged; Arginine; Calcinosis; Coronary Artery Disease; Female; Glycation End Products, Advanced; Humans; Indican; Lysine; Male; Middle Aged; Oxidative Stress; Prognosis; Renal Dialysis; Severity of Illness Index; Uremia | 2006 |
Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats.
Topics: Administration, Oral; Alkaline Phosphatase; Animals; Bone and Bones; Calcium; Carbon; Charcoal; Chromatography, High Pressure Liquid; Creatine; Gene Expression; Indican; Male; Organic Anion Transporters, Sodium-Independent; Osteoblasts; Osteogenesis; Oxides; Parathyroid Hormone; Phosphorus; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tibia; Uremia | 2006 |
In-vitro study on the competitive binding of diflunisal and uraemic toxins to serum albumin and human plasma using a potentiometric ion-probe technique.
Topics: Algorithms; Animals; Binding, Competitive; Blood Proteins; Calibration; Diflunisal; Hippurates; Humans; Indican; Indoleacetic Acids; Ion-Selective Electrodes; Potentiometry; Serum Albumin; Serum Albumin, Bovine; Technology, Pharmaceutical; Toxins, Biological; Uremia | 2006 |
Indoxyl sulfate and atherosclerotic risk factors in hemodialysis patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Atherosclerosis; Biomarkers; C-Reactive Protein; Cholesterol, HDL; Chromatography, High Pressure Liquid; Creatinine; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glycation End Products, Advanced; Humans; Incidence; Indican; Lysine; Male; Middle Aged; Nephelometry and Turbidimetry; Renal Dialysis; Uremia | 2007 |
Indican interference in bilirubin assays: a classical solution still applies.
Topics: Bilirubin; Diazonium Compounds; Humans; Indican; Indicators and Reagents; Reagent Kits, Diagnostic; Uremia | 2007 |
The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells.
Topics: Antioxidants; Base Sequence; Cells, Cultured; Endothelial Cells; Humans; Indican; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Uremia; Xanthine Oxidase | 2007 |
New approaches to the removal of protein-bound toxins from blood plasma of uremic patients.
Topics: Adsorption; Binding Sites; Calorimetry, Differential Scanning; Charcoal; Furans; Hemoperfusion; Hippurates; Humans; Hydrogen-Ion Concentration; Indican; Membranes, Artificial; Plasma; Propionates; Protein Binding; Reference Values; Renal Dialysis; Serum Albumin; Toxins, Biological; Treatment Outcome; Uremia | 2007 |
Oral sorbent AST-120 increases renal NO synthesis in uremic rats.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Carbon; Creatinine; Disease Models, Animal; Indican; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type III; Oxides; Rats; Rats, Sprague-Dawley; Reference Values; Uremia | 2008 |
Indoxyl sulfate reduces superoxide scavenging activity in the kidneys of normal and uremic rats.
Topics: Animals; Case-Control Studies; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Half-Life; Immunohistochemistry; Indican; Kidney; Kidney Failure, Chronic; Pyrrolidines; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Uremia | 2008 |
Decreased drug binding in uraemia: effect of indoxyl sulphate and other endogenous substances on the binding of drugs and dyes to human albumin.
Topics: Azo Compounds; Coloring Agents; Humans; In Vitro Techniques; Indican; ortho-Aminobenzoates; Protein Binding; Serum Albumin; Tryptophan; Uremia | 1982 |
Fast atom bombardment mass spectrometric determination of the molecular weight range of uremic compounds that displace phenytoin from protein binding: absence of midmolecular uremic toxins.
Topics: Drug Interactions; Guanidine; Guanidines; Hippurates; Humans; In Vitro Techniques; Indican; Methylguanidine; Phenytoin; Protein Binding; Renal Dialysis; Spectrometry, Mass, Fast Atom Bombardment; Succinates; Toxins, Biological; Uremia | 1994 |
Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate.
Topics: Animals; Glomerulosclerosis, Focal Segmental; Indican; Indoles; Kidney Glomerulus; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Tryptophan; Uremia | 1994 |
Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis.
Topics: Aged; Animals; Carbon; Dietary Proteins; Female; Glomerulosclerosis, Focal Segmental; Humans; Indican; Kidney; Male; Middle Aged; Oxides; Rats; Rats, Sprague-Dawley; Uremia | 1994 |
A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia.
Topics: Adsorption; Animals; Biological Transport; Cells, Cultured; Furans; Hippurates; Humans; Indican; Iodides; Kidney Failure, Chronic; Liver; Male; Propionates; Rats; Rats, Wistar; Renal Dialysis; Thyroxine; Uremia | 1993 |
Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis.
Topics: Administration, Oral; Adult; Bacteria, Aerobic; Bacteria, Anaerobic; Bifidobacterium; Capsules; Cresols; Enterococcus faecalis; Feces; Female; Humans; Indican; Lactobacillus acidophilus; Male; Middle Aged; Phenol; Phenols; Renal Dialysis; Uremia | 1996 |
Indoxyl sulfate increases the gene expressions of TGF-beta 1, TIMP-1 and pro-alpha 1(I) collagen in uremic rat kidneys.
Topics: Administration, Oral; Animals; Blotting, Northern; DNA Probes; Gene Expression; Indican; Injections, Intraperitoneal; Kidney Cortex; Male; Nephrectomy; Procollagen; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Uremia | 1997 |
The protein metabolite hypothesis, a model for the progression of renal failure: an oral adsorbent lowers indoxyl sulfate levels in undialyzed uremic patients.
Topics: Administration, Oral; Adsorption; Aged; Carbon; Creatinine; Female; Humans; Indican; Kidney Failure, Chronic; Male; Microspheres; Middle Aged; Oxides; Uremia | 1997 |
Elevated free fosphenytoin concentrations in uremic sera: uremic toxins hippuric acid and indoxyl sulfate do not account for the impaired protein binding of fosphenytoin.
Topics: Anticonvulsants; Drug Interactions; Fluorescence Polarization Immunoassay; Hippurates; Humans; Indican; Phenytoin; Protein Binding; Serum Albumin; Uremia | 1998 |
Intradialytic removal of protein-bound uraemic toxins: role of solute characteristics and of dialyser membrane.
Topics: Aged; Aged, 80 and over; Creatinine; Cresols; Female; Furans; Hippurates; Humans; Indican; Kidneys, Artificial; Male; Membranes, Artificial; Middle Aged; Propionates; Protein Binding; Renal Dialysis; Toxins, Biological; Urea; Uremia | 2000 |
Decreased bilirubin-binding capacity in uremic serum caused by an accumulation of furan dicarboxylic acid.
Topics: Adult; Bilirubin; Furans; Humans; Indican; Kidney Failure, Chronic; Male; Middle Aged; Propionates; Protein Binding; Serum Albumin; Uremia | 2000 |
An oral sorbent reduces overload of indoxyl sulphate and gene expression of TGF-beta1 in uraemic rat kidneys.
Topics: Adsorption; Animals; Blood Urea Nitrogen; Carbon; Creatinine; Gene Expression Regulation; Indican; Male; Nephrectomy; Oxides; Procollagen; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Uremia | 2000 |
Interaction mechanism between indoxyl sulfate, a typical uremic toxin bound to site II, and ligands bound to site I of human serum albumin.
Topics: Anticoagulants; Asparagine; Binding Sites; Dansyl Compounds; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Indican; Ligands; Serum Albumin; Toxins, Biological; Uremia; Warfarin | 2001 |
Uremic sera contain inhibitors that block digitoxin-valproic acid interaction.
Topics: Anticonvulsants; Binding Sites; Binding, Competitive; Cardiotonic Agents; Digitoxin; Drug Interactions; Hippurates; Humans; In Vitro Techniques; Indican; Protein Binding; Serum Albumin; Uremia; Valproic Acid | 2001 |
The protein metabolite theory as a mechanism for the progression of renal failure.
Topics: Carbon; Dietary Proteins; Disease Progression; Humans; Indican; Kidney Failure, Chronic; Oxides; Uremia | 2001 |
Combination therapy with benazepril and oral adsorbent ameliorates progressive renal fibrosis in uremic rats.
Topics: Adsorption; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Carbon; Cells, Cultured; Disease Progression; Drug Therapy, Combination; Fibroblasts; Fibrosis; Humans; In Situ Hybridization; Indican; Kidney; Kidney Diseases; Male; Nephrectomy; Nephrosclerosis; Osteopontin; Oxides; Rats; Rats, Sprague-Dawley; Sialoglycoproteins; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Transforming Growth Factor beta1; Uremia | 2002 |
Suppressed serum and urine levels of indoxyl sulfate by oral sorbent in experimental uremic rats.
Topics: Adsorption; Animals; Carbon; Chromatography, High Pressure Liquid; Female; Hippurates; Indican; Intestine, Small; Kidney; Liver; Oxides; Rats; Rats, Sprague-Dawley; Uremia | 1992 |
Inhibitory effect of oral sorbent on accumulation of albumin-bound indoxyl sulfate in serum of experimental uremic rats.
Topics: Administration, Oral; Animals; Carbon; Chromatography, High Pressure Liquid; Creatine; Indican; Indoles; Male; Nephrectomy; Nitrogen; Oxides; Rats; Rats, Inbred Strains; Serum Albumin; Uremia | 1991 |
[Effect of oral sorbent, AST-120, on serum concentration of indoxyl sulfate in uremic rats].
Topics: Administration, Oral; Adsorption; Animals; Carbon; Female; Indican; Microspheres; Oxides; Rats; Rats, Inbred Strains; Uremia | 1990 |
Effect of hemodialysis on serum concentrations of HPLC-analyzed accumulating solutes in uremia.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Proteins; Chromatography, High Pressure Liquid; Female; Hematocrit; Hippurates; Humans; Indican; Male; Middle Aged; Protein Binding; Renal Dialysis; Uremia | 1989 |
[Study on the uremic protein binding inhibitors as uremic toxin: toxic effect on erythroid colony formation, lymphocyte blast formation and renal function].
Topics: Animals; Cell Division; Cells, Cultured; Erythroid Precursor Cells; Hippurates; In Vitro Techniques; Indican; Kidney Tubules; Lymphocyte Activation; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Sodium; Uremia | 1989 |
Determination of indoxyl sulfate in plasma of patients with renal failure by use of ion-pairing liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Creatinine; Indican; Quaternary Ammonium Compounds; Uremia | 1986 |
Profiling of endogenous ligand solutes that bind to serum proteins in sera of patients with uremia.
Topics: Blood Proteins; Chromatography, High Pressure Liquid; Hippurates; Hot Temperature; Humans; Indican; Indoleacetic Acids; Ligands; Protein Binding; Ultrafiltration; Uremia | 1986 |
Determination of indican and tryptophan in normal and uraemic patients by high-performance liquid chromatography with a new electrochemical detector.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Indican; Indicators and Reagents; Tryptophan; Uremia | 1986 |
Contributions of hippurate, indoxyl sulfate, and o-hydroxyhippurate to impaired ligand binding by plasma in azotemic humans.
Topics: Blood Proteins; Calcium; Chlorides; Creatinine; Hippurates; Humans; Indican; Kidney Failure, Chronic; Ligands; Salicylates; Salicylic Acid; Uremia | 1987 |
Roles of hippurate and indoxyl sulfate in the impaired ligand binding by azotemic plasma.
Topics: Blood Proteins; Hippurates; Humans; Indican; Protein Binding; Salicylates; Salicylic Acid; Toxins, Biological; Uremia | 1987 |
Inhibition of hepatic glutathione S-transferases by a major endogenous ligand substance present in uremic serum.
Topics: Animals; Cattle; Dinitrochlorobenzene; Furans; Glutathione Transferase; Humans; Indican; Indoleacetic Acids; Liver; Propionates; Protein Binding; Rats; Serum Albumin; Uremia | 1988 |
Displacement by anionic drugs of endogenous ligands bound to albumin in uremic serum.
Topics: Binding Sites; Furans; Hippurates; Humans; Indican; Indoleacetic Acids; Propionates; Protein Binding; Salicylates; Salicylic Acid; Serum Albumin; Uremia; Warfarin | 1988 |
Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography.
Topics: Albumins; beta 2-Microglobulin; Chromatography, High Pressure Liquid; Furans; Humans; Indican; Propionates; Renal Dialysis; Salicylates; Uremia | 1988 |
Rapid assay for indoxyl sulphate in uremic serum by internal-surface reversed-phase high-performance liquid chromatography.
Topics: Blood Proteins; Humans; Indican; Mass Spectrometry; Renal Dialysis; Spectrophotometry, Ultraviolet; Uremia | 1988 |
Liquid-chromatographic study of fluorescent compounds in hemodialysate solutions.
Topics: Chromatography, High Pressure Liquid; Humans; Indican; Indoleacetic Acids; Renal Dialysis; Solutions; Spectrometry, Fluorescence; Tryptophan; Tryptophanase; Uremia | 1985 |
A 2,4-dichlorophenyl diazonium-based method for total bilirubin without interference from indican in uremic sera.
Topics: Bilirubin; Diazonium Compounds; Humans; Indican; Methods; Spectrophotometry; Uremia | 1985 |
Diagnosis of uraemia post mortem.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Autopsy; Blood Chemical Analysis; Cerebrospinal Fluid; Child; Child, Preschool; Creatinine; Female; Humans; Indican; Infant; Kidney Failure, Chronic; Male; Middle Aged; Postmortem Changes; Sulfates; Urea; Uremia; Urine | 1969 |
A perspective on uremic toxins.
Topics: Ammonia; Animals; Blood Urea Nitrogen; Creatinine; Diet Therapy; Guanidines; Humans; Indican; Kidney Failure, Chronic; Phenols; Renal Dialysis; Sodium; Toxins, Biological; Urea; Uremia; Water-Electrolyte Balance | 1970 |
Studies on the pathogenesis of uremia. Comparative determinations of glucuronic acid, indican, free and bound phenols in the serum, cerebrospinal fluid, and urine of renal diseases with and without uremia.
Topics: Blood Chemical Analysis; Cerebrospinal Fluid; Chemistry, Clinical; Coma; Glucuronates; Humans; Indican; Kidney Diseases; Phenols; Uremia; Urine | 1965 |