indican has been researched along with Disease Models, Animal in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (10.45) | 29.6817 |
| 2010's | 42 (62.69) | 24.3611 |
| 2020's | 18 (26.87) | 2.80 |
| Authors | Studies |
|---|---|
| Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Cetinkaya, MA; Kepekci-Tekkeli, SE; Kul, O; Melekoglu, E; Samur, G | 1 |
| Anderson, S; Arinze, NV; Belghasem, M; Chitalia, VC; Farber, A; Francis, J; Hamburg, NM; Hassan Kamel, M; Lee, N; Lotfollahzadeh, S; Napoleon, MA; Rahimi, N; Ravid, JD; Richards, S; Sherr, D; Siracuse, JJ; Walker, JA; Whelan, SA; Yin, W | 1 |
| Li, H; Yang, J; Zhang, C; Zhou, Y | 1 |
| Eiam-Ong, S; Katavetin, P; Leelahavanichkul, A; Panpetch, W; Praditpornsilpa, K; Saisorn, W; Tumwasorn, S; Tungsanga, K; Tungsanga, S; Udompornpitak, K | 1 |
| Burtey, S; Cerini, C; McKay, N; Poitevin, S; Vial, R | 1 |
| Donouchi, M; Kamada, S; Kanda, M; Kobuchi, S; Matsumura, Y; Nakagawa, K; Ohkita, M; Tanaka, R; Tawa, M | 1 |
| Horikawa, M; Hou, H; Izumi, Y; Jono, H; Kakizoe, Y; Kuwabara, T; Mukoyama, M; Narita, Y; Saito, H | 1 |
| Guo, BC; Huang, PH; Kuo, KL; Lee, TS; Tarng, DC; Zhao, JF | 1 |
| Lin, CJ; Lin, FH; Sun, CY; Wu, CC; Wu, CJ; Wu, V | 1 |
| Huang, PH; Liou, JY; Shih, YC; Tarng, DC; Wang, SC; Wu, CC | 1 |
| Chang, JF; Chen, YW; Hsieh, CY; Hung, CF; Liang, SS; Lin, CC; Liou, JC; Lu, KC; Wu, MS | 1 |
| Dong, X; Li, P; Ma, L; Peng, L; Wang, Q; Yan, M; Yin, X; Zhang, H; Zhao, H; Zhao, T | 1 |
| Bi, X; Chen, Y; Han, W; He, T; Huang, Y; Li, Y; Liu, Y; Qiao, Y; Wang, S; Xiao, T; Xiong, J; Yang, K; Yu, Y; Zhao, J; Zhou, J | 1 |
| Al Salam, S; Al Suleimani, Y; Al Za'abi, M; Ali, BH; Ashique, M; Manoj, P; Nemmar, A | 1 |
| Cao, YG; Fenn, K; Garrett, WS; Glickman, JN; Lobel, L | 1 |
| Al-Kassou, B; Böhm, M; Düsing, P; Goody, PR; Hosen, MR; Jamme, P; Jansen, F; Liu, W; Nickenig, G; Niepmann, S; Pfeifer, A; Reiners, KS; Steffen, E; Werner, N; Zietzer, A; Zimmer, S | 1 |
| Chen, TW; Huang, HD; Liang, SS; Lu, WL; Tarng, DC; Tseng, CP; Yang, CY | 1 |
| Bernasconi, H; Díaz-Castillo, ST; Echeverría, G; Fuentealba, J; García-Cancino, A; Jerez-Morales, A; Merino, JS; Smith, CT | 1 |
| Al Kalbani, J; Al Suleimani, Y; Al Za'abi, M; Ali, BH; Ashique, M; Karaca, T; Nemmar, A | 1 |
| Arake, R; Enoki, Y; Fujimura, R; Fukagawa, M; Imafuku, T; Ishima, Y; Ishiodori, K; Komaba, H; Maruyama, T; Matsushita, K; Miyamura, S; Nagao, S; Nishida, K; Otagiri, M; Sugimoto, R; Tanaka, M; Watanabe, H | 1 |
| Hamano, H; Horinouchi, Y; Ikeda, Y; Imanishi, M; Ishizawa, K; Izawa-Ishizawa, Y; Miyamoto, L; Takechi, K; Tamaki, T; Tsuchiya, K; Watanabe, H; Zamami, Y | 1 |
| Chang, YL; Hsu, SC; Hsu, YJ; Huang, SM; Lin, CY; Shih, CC; Tsai, CS | 1 |
| Brunet, P; Burtey, S; Cerini, C; Dignat-George, F; Jourde-Chiche, N; Legris, T; Masereeuw, R; McKay, N; Mouly-Bandini, A; Paul, P; Poitevin, S; Santana Machado, T | 1 |
| Addi, T; Brunet, P; Burtey, S; Cerini, C; Denison, MS; Dignat-George, F; Dou, L; Duval-Sabatier, A; Gondouin, B; Jourde-Chiche, N; McKay, N; Poitevin, S; Sallée, M | 1 |
| Fujimori, S; Higashino, T; Ichida, K; Matsuo, H; Miyata, H; Nakashima, A; Nakayama, A; Ooyama, H; Ooyama, K; Sakiyama, M; Shinomiya, N; Suzuki, H; Takada, T; Tan, JK; Toyoda, Y; Yamamoto, T; Yamanashi, Y | 1 |
| Bennis, Y; Bouabdallah, J; Caus, T; Choukroun, G; Issa, H; Kamel, S; Kchour, G; Lenglet, G; Six, I; Zibara, K | 1 |
| Aikawa, E; Aikawa, M; Anderson, DG; Aster, JC; Barabási, AL; Boff, MS; Chen, M; Decano, JL; Golden, WS; Guimaraes, GC; Halu, A; Higashi, H; Iwata, H; Katsuki, S; Kauffman, KJ; Kum, AST; Kuromoto, RK; Lee, LH; Maejima, T; Nakano, T; Pestana, DVS; Sharma, A; Singh, SA; Suzuki, T | 1 |
| Asakura, M; Asano, Y; Asanuma, H; Chung, H; Fukuda, H; Funayama, M; Ihara, M; Imazu, M; Ito, S; Kitakaze, M; Min, KD; Minamino, T; Morita, T; Ogai, A; Sugimachi, M; Takahama, H; Takashima, S | 1 |
| Azmi, A; D'Haese, PC; De Leger, W; De Maré, A; Evenepoel, P; Maudsley, S; Meijers, B; Neven, E; Opdebeeck, B; Verhulst, A | 1 |
| Ayajiki, K; Ito, S; Jun-Ichi, S; Kobuchi, S; Manabe, E; Masuyama, T; Ohno, Y; Tanaka, T; Tsujino, T | 1 |
| Abe, T; Akiyama, Y; Ishida, A; Ito, S; Jinno, D; Kikuchi, K; Mishima, E; Moriguchi, T; Saigusa, D; Shima, H; Souma, T; Sugawara, D; Suzuki, C; Suzuki, T; Takeuchi, Y; Tomioka, Y; Toyohara, T; Yamamoto, Y | 1 |
| Hwang, YJ; Jeong, KT; Park, JH; Yun, MO | 1 |
| Enomoto, A; Nishijima, F; Niwa, T; Saito, S; Shimizu, H; Yisireyili, M | 1 |
| Glorieux, G; Nagler, EV; Pletinck, A; Schepers, E; Vanholder, R | 1 |
| Jono, H; Matsunaga, R; Nishi, K; Nomura, Y; Sagata, M; Saigo, C; Saito, H; Yamamoto, Y | 1 |
| Al Shukaili, A; Al Za'abi, M; Ali, BH; Nemmar, A | 1 |
| Adelibieke, Y; Ng, HY; Nishijima, F; Niwa, T; Saito, S; Yisireyili, M | 1 |
| Anraku, M; Hirayama, F; Iohara, D; Maruyama, T; Otagiri, M; Taguchi, K; Uekama, K; Wada, K | 1 |
| Asai, H; Hirai, K; Hirata, J; Inada, M; Matsumoto, C; Miyaura, C; Watanabe-Akanuma, M; Yamato, H | 1 |
| Chen, HH; Lin, CJ; Liou, TC; Liu, HL; Pan, CF; Sun, FJ; Wu, CJ; Wu, PC | 1 |
| Aoki, K; Fukui, A; Fukunaga, N; Kondo, H; Nawata, T; Saito, S; Shibata, H; Shimada, T; Takahashi, N; Teshima, Y | 1 |
| Hou, YC; Lee Chao, PD; Lin, SP; Peng, YH; Sweet, DH; Yu, CP | 1 |
| Gao, Y; Gao, Z; Wang, L | 1 |
| Chen, YL; Huang, TM; Liang, CJ; Liu, CW; Peng, YS; Shen, WC; Tsai, JS; Tseng, YC; Wang, SH; Wu, VC; Young, GH | 1 |
| Chen, JW; Huang, HL; Huang, PH; Hung, SC; Kuo, KL; Lin, CC; Lin, SJ; Tarng, DC; Tsai, TH; Wang, CH | 1 |
| Chen, M; Dong, M; Du, Y; Gao, H; Ji, J; Liao, S; Zhao, L; Zheng, H; Zhou, Q | 1 |
| Arake, R; Enoki, Y; Fukagawa, M; Imafuku, T; Ishima, Y; Kotani, S; Maruyama, T; Matsushita, K; Nakajima, M; Otagiri, M; Sugimoto, R; Tanaka, M; Tominaga, Y; Watanabe, H | 1 |
| Hattori, M; Itoh, Y; Kikuchi, M; Suda, W; Ueno, M | 1 |
| Abe, T; Ito, S; Kisu, K; Koizumi, K; Kudo, T; Kurasawa, N; Mishima, E; Miura, D; Mokudai, T; Mori, T; Morikawa-Ichinose, T; Naganuma, E; Niwa, T; Niwano, Y; Oba-Yabana, I; Oe, Y; Saigusa, D; Saito, R; Sato, E; Sato, H; Sugawara, S; Suzuki, A; Suzuki, C; Takahashi, N | 1 |
| Devlin, AS; Dodd, D; Fischbach, MA; Marcobal, A; Meyer, T; Nayfach, S; Plummer, N; Pollard, KS; Sonnenburg, JL | 1 |
| Ezawa, A; Itoh, Y; Kikuchi, K; Murakami, K; Niwa, T; Tateoka, R | 1 |
| Fasching, A; Fujita, T; Hansell, P; Kawakami, T; Nangaku, M; Nishijima, F; Nordquist, L; Palm, F; Tanaka, T | 1 |
| Fujita, T; Inagi, R; Kawakami, T; Nangaku, M; Tanaka, T; Wada, T | 1 |
| Hwang, GS; Kim, HS; Kim, KB; Kim, YJ; Kwack, SJ; Lee, BM; Park, KL; Ryu, DH; Yang, JY | 1 |
| Adijiang, A; Higuchi, Y; Nishijima, F; Niwa, T; Shimizu, H | 1 |
| Abe, T; Akiyama, Y; Ito, S; Kikuchi, K; Mishima, E; Nagao, S; Soga, T; Suzuki, C; Suzuki, T; Takeuchi, Y; Tanemoto, M; Toyohara, T; Yoshihara, D | 1 |
| Hamada, A; Kamobayashi, H; Kohda, Y; Komori, M; Kusumoto, M; Saito, H; Sato, D; Tomita, K; Yoshimura, M | 1 |
| Nishijima, F; Niwa, T; Shimizu, H; Yisireyili, M | 1 |
| Hsu, SC; Hsu, YJ; Huang, SM; Lee, HS; Lin, CY; Lin, SH; Shih, CC; Tsai, CS | 1 |
| Higuchi, Y; Ishii, H; Ito, S; Nishijima, F; Osaka, M; Yagi, Y; Yamato, H; Yoshida, M | 1 |
| Deguchi, T; Nakamura, M; Otagiri, M; Suenaga, A; Tsutsumi, Y | 1 |
| Ahmed, IH; Ali, BH | 1 |
| Hamada, A; Iwata, K; Matsuzaki, T; Morisaki, T; Ohmura, T; Saito, H; Watanabe, H | 1 |
| Anraku, M; Fukunaga, E; Hashimoto, M; Kitamura, K; Maruyama, T; Otagiri, M; Shimoishi, K; Taguchi, K; Tasaki, Y | 1 |
| Niwa, T; Tumur, Z | 1 |
| Adijiang, A; Goto, S; Nishijima, F; Niwa, T; Uramoto, S | 1 |
1 review(s) available for indican and Disease Models, Animal
| Article | Year |
|---|---|
The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review.
Topics: Animals; Cresols; Disease Models, Animal; Humans; Indican; Kidney; Models, Biological; Protein Binding; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2014 |
66 other study(ies) available for indican and Disease Models, Animal
| Article | Year |
|---|---|
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger | 2004 |
Effects of prebiotic oligofructose-enriched inulin on gut-derived uremic toxins and disease progression in rats with adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Blood Urea Nitrogen; Cresols; Disease Models, Animal; Dysbiosis; Humans; Indican; Inflammation; Interleukin-6; Inulin; Oligosaccharides; Prebiotics; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Urea | 2021 |
Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease.
Topics: Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Disease Models, Animal; Hindlimb; Humans; Indican; Ischemia; Kynurenine; Mice; Middle Aged; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Tryptophan; Wnt Signaling Pathway | 2022 |
Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-κB signaling pathways.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Electrocardiography; Gene Expression Regulation; Indican; Male; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; NF-kappa B; Patch-Clamp Techniques; Rats; Rats, Wistar; Renal Insufficiency, Chronic; RNA; Shaker Superfamily of Potassium Channels; Signal Transduction; Tachycardia, Ventricular | 2022 |
Lactobacillus rhamnosus L34 attenuates chronic kidney disease progression in a 5/6 nephrectomy mouse model through the excretion of anti-inflammatory molecules.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Culture Media, Conditioned; Disease Models, Animal; Fibrosis; Humans; Indican; Inflammation; Lacticaseibacillus rhamnosus; Mice; Nephrectomy; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha | 2022 |
Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.
Topics: Animals; C-Reactive Protein; Carbazoles; Cells, Cultured; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Indican; Indoleacetic Acids; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Uremia | 2022 |
Vascular Endothelial Dysfunction in the Thoracic Aorta of Rats with Ischemic Acute Kidney Injury: Contribution of Indoxyl Sulfate.
Topics: Acute Kidney Injury; Animals; Aorta, Thoracic; Carbon; Disease Models, Animal; Disease Progression; Endothelial Cells; Endothelium, Vascular; Indican; Ischemia; Male; Nitric Oxide; Oxides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Renal Insufficiency, Chronic; Reperfusion Injury; Signal Transduction | 2022 |
Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice.
Topics: Animals; Disease Models, Animal; Erythropoietin; Fibrosis; Humans; Indican; Inflammation; Kidney; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic; Sulfotransferases; Ureteral Obstruction | 2023 |
Indoxyl sulfate impairs valsartan-induced neovascularization.
Topics: Animals; Cell Line; Disease Models, Animal; Hindlimb; Humans; Indican; Ischemia; Male; Mice; Neovascularization, Physiologic; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Protein Kinase C-alpha; Signal Transduction; Valsartan | 2020 |
CharXgen-Activated Bamboo Charcoal Encapsulated in Sodium Alginate Microsphere as the Absorbent of Uremic Toxins to Retard Kidney Function Deterioration.
Topics: Alginates; Animals; Carbon; Cell Line; Charcoal; Cresols; Disease Models, Animal; Humans; Indican; Microscopy, Electron, Scanning; Microspheres; Oxides; Rats; Renal Insufficiency, Chronic; Sasa; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2020 |
Oral Charcoal Adsorbents Attenuate Neointima Formation of Arteriovenous Fistulas.
Topics: Administration, Oral; Adsorption; Animals; Arteriovenous Shunt, Surgical; Carbon; Collagen; Disease Models, Animal; Graft Occlusion, Vascular; Indican; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Neointima; Oxides; Renal Insufficiency, Chronic; Toxins, Biological; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Uremia; Vascular Patency | 2020 |
Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease.
Topics: Animals; Aristolochic Acids; Cresols; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Indican; JNK Mitogen-Activated Protein Kinases; Kidney Tubules; Mice, Inbred C57BL; Propolis; Renal Insufficiency, Chronic; Signal Transduction; Smad2 Protein; Smad3 Protein; Sulfuric Acid Esters; Transforming Growth Factor beta; Uremia | 2020 |
Tangshen formula modulates gut Microbiota and reduces gut-derived toxins in diabetic nephropathy rats.
Topics: Animals; Bacteria; Cytokines; Diabetic Nephropathies; Disease Models, Animal; Drugs, Chinese Herbal; Dysbiosis; Gastrointestinal Microbiome; Indican; Inflammation Mediators; Intestines; Kidney; Lipopolysaccharides; Male; Rats, Wistar | 2020 |
Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment.
Topics: Adsorption; Animals; Carbon; Disease Models, Animal; Dynamins; Epithelial Cells; Gastrointestinal Agents; Humans; Indican; Interferon Regulatory Factor-1; Intestinal Diseases; Intestinal Mucosa; Kidney; Male; Mice; Mitophagy; Oxides; Permeability; Renal Elimination; Renal Insufficiency, Chronic; Tight Junctions | 2020 |
Effects of repeated increasing doses of cisplatin as models of acute kidney injury and chronic kidney disease in rats.
Topics: Acute Kidney Injury; Albuminuria; Animals; Antineoplastic Agents; Caspase 3; Cisplatin; Creatinine; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acid-Binding Proteins; Indican; Kidney; Male; NF-E2-Related Factor 2; Phosphorus; Rats, Wistar; Renal Insufficiency, Chronic; Urea; Uric Acid | 2021 |
Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function.
Topics: Animals; Diet; Dietary Proteins; Disease Models, Animal; Disease Progression; Escherichia coli; Gastrointestinal Microbiome; Hydrogen Sulfide; Indican; Kidney; Mice; Protein Processing, Post-Translational; Proteome; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophanase | 2020 |
MicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease.
Topics: Adult; Aged; Aged, 80 and over; Animals; Carotid Arteries; Carotid Artery Injuries; Case-Control Studies; Cell Communication; Cell Proliferation; Cells, Cultured; Coronary Artery Disease; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Extracellular Vesicles; Female; Humans; Indican; Male; Mice, Inbred C57BL; MicroRNAs; Middle Aged; Renal Insufficiency, Chronic | 2022 |
Synbiotics Alleviate the Gut Indole Load and Dysbiosis in Chronic Kidney Disease.
Topics: Adenine; Aged; Animals; Bacteria; Biodiversity; Body Weight; Diet; Disease Models, Animal; Dysbiosis; Feces; Female; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Indican; Indoles; Kidney; Male; Middle Aged; Rats; Renal Insufficiency, Chronic; Synbiotics; Time Factors | 2021 |
The Administration of the Synbiotic
Topics: Animals; Creatinine; Disease Models, Animal; Disease Progression; Female; Fibrosis; Heart Diseases; Indican; Inulin; Kidney; Lactobacillus delbrueckii; Myocardium; Oligosaccharides; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Synbiotics; Toxins, Biological | 2021 |
The effect of swimming exercise on adenine-induced kidney disease in rats, and the influence of curcumin or lisinopril thereon.
Topics: Adenine; Animals; Antioxidants; Blood Pressure; Creatinine; Curcumin; Disease Models, Animal; Female; Immunohistochemistry; Indican; Kidney; Lisinopril; Physical Conditioning, Animal; Protective Agents; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Serum Albumin; Swimming; Urea | 2017 |
Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction.
Topics: Animals; Antioxidants; Biomarkers; Cell Line; Chromatography, High Pressure Liquid; Creatinine; Cytokines; Disease Models, Animal; Humans; Indican; Inflammation Mediators; Male; Mice; Mitochondria; Myoblasts; Nitrogen; Phosphorylation; Proto-Oncogene Proteins c-akt; Renal Insufficiency, Chronic; Sarcopenia | 2017 |
The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease.
Topics: Adenine; Animals; Disease Models, Animal; Gene Expression Regulation; Hep G2 Cells; Hepcidins; Humans; Indican; Iron; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Renal Insufficiency, Chronic | 2018 |
Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy.
Topics: Activating Transcription Factor 3; Animals; Cardiomyopathies; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Indican; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Rats; Receptor, Cannabinoid, CB1; Signal Transduction; Up-Regulation; Uremia | 2018 |
Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling.
Topics: Albumins; Animals; ATP Binding Cassette Transporter, Subfamily B; Cyclosporine; Disease Models, Animal; Female; Gene Expression; Heart Transplantation; Hep G2 Cells; Humans; Immunosuppressive Agents; Indican; Kidney Transplantation; Liver; Male; Mice; Middle Aged; Multidrug Resistance-Associated Protein 2; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; RNA, Messenger; Signal Transduction; Up-Regulation | 2018 |
Aryl hydrocarbon receptor is activated in patients and mice with chronic kidney disease.
Topics: Adult; Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors; Cardiovascular Diseases; Case-Control Studies; Cause of Death; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Disease Models, Animal; Female; Humans; Indican; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Prospective Studies; Receptors, Aryl Hydrocarbon; Renal Dialysis; Renal Insufficiency, Chronic; Repressor Proteins; Risk Factors; Treatment Outcome | 2018 |
Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.
Topics: Adenine; Adenosine Triphosphate; Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Chromatography, Liquid; Disease Models, Animal; Disease Progression; Gene Knockout Techniques; Half-Life; HEK293 Cells; Humans; Indican; Mice; Mice, Knockout; Neoplasm Proteins; Renal Elimination; Renal Insufficiency, Chronic; Tandem Mass Spectrometry; Toxins, Biological; Transport Vesicles | 2018 |
Endothelial cells exposed to phosphate and indoxyl sulphate promote vascular calcification through interleukin-8 secretion.
Topics: Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Human Umbilical Vein Endothelial Cells; Humans; Indican; Interleukin-8; Male; Myocytes, Smooth Muscle; Phosphates; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Vascular Calcification | 2019 |
Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Atherosclerosis; Calcium-Binding Proteins; Disease Models, Animal; Humans; Indican; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Macrophage Activation; Macrophages; Male; Membrane Proteins; Mice; Mice, Knockout; Organic Anion Transporters; Phenotype; Plaque, Atherosclerotic; RAW 264.7 Cells; Receptors, LDL; Receptors, Notch; Renal Insufficiency, Chronic; Signal Transduction; Vascular Calcification | 2019 |
AST-120, an Adsorbent of Uremic Toxins, Improves the Pathophysiology of Heart Failure in Conscious Dogs.
Topics: Adsorption; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbon; Cardio-Renal Syndrome; Consciousness; Disease Models, Animal; Dogs; Fibrosis; Heart Failure; Hemodynamics; Indican; Kidney Diseases; Mitochondria, Heart; Myocardium; Oxides; Signal Transduction; Sorption Detoxification; Uremia; Ventricular Function, Left | 2019 |
Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance.
Topics: Animals; Biological Products; Biopsy, Needle; Carbamates; Disease Models, Animal; Glucose Intolerance; Immunohistochemistry; Indican; Male; Metformin; Polyesters; Random Allocation; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Sensitivity and Specificity; Vascular Calcification | 2019 |
Neutrophil/lymphocyte ratio elevation in renal dysfunction is caused by distortion of leukocyte hematopoiesis in bone marrow.
Topics: Adenine; Aged; Aged, 80 and over; Animals; Biomarkers; Bone Marrow; Carbon; Cardiovascular Diseases; Disease Models, Animal; Female; Glomerular Filtration Rate; Hematopoiesis; Humans; Indican; Kidney Diseases; Lymphocyte Count; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Middle Aged; Neutrophils; Oxides; Prognosis; Retrospective Studies; Risk Factors | 2019 |
Indoxyl sulfate down-regulates SLCO4C1 transporter through up-regulation of GATA3.
Topics: Animals; Biological Transport; Carbon; Cell Line; Disease Models, Animal; Down-Regulation; GATA3 Transcription Factor; Gene Expression Regulation; Humans; Indican; Kidney Failure, Chronic; Organic Anion Transporters; Oxides; Rats; Toxins, Biological | 2013 |
Uremic toxin indoxyl 3-sulfate regulates the differentiation of Th2 but not of Th1 cells to lessen allergic asthma.
Topics: Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; Benzoflavones; Bronchoalveolar Lavage Fluid; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Immunoglobulin E; Indican; Interleukin-4; Male; Mice; Mice, Inbred C57BL; Ovalbumin; Phosphorylation; Pulmonary Eosinophilia; Receptors, Aryl Hydrocarbon; STAT5 Transcription Factor; STAT6 Transcription Factor; Th1 Cells; Th2 Cells; Uremia | 2014 |
Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.
Topics: Actins; Animals; Carbon; Cell Line; Chelating Agents; Disease Models, Animal; Fibrosis; Humans; Hypertension, Renal; Indican; Kidney Tubules, Proximal; Male; Oxides; Prorenin Receptor; Random Allocation; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Renal Insufficiency, Chronic; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Transforming Growth Factor beta1; Up-Regulation | 2014 |
Meclofenamate elicits a nephropreventing effect in a rat model of ischemic acute kidney injury by suppressing indoxyl sulfate production and restoring renal organic anion transporters.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Down-Regulation; Indican; Inhibitory Concentration 50; Liver; Male; Meclofenamic Acid; Organic Anion Transporters; Polyphenols; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2014 |
High-mobility group box-1 protein in adenine-induced chronic renal failure and the influence of gum arabic thereon.
Topics: Adenine; Animals; Biomarkers; Creatinine; Disease Models, Animal; Gum Arabic; HMGB1 Protein; Indican; Inflammation Mediators; Kidney; Kidney Failure, Chronic; Male; Rats, Wistar; Time Factors; Urea | 2015 |
Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-κB pathway.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; eIF-2 Kinase; Endothelium, Vascular; Humans; Indican; Interleukin-6; Muscle, Smooth, Vascular; NF-kappa B; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Inbred Dahl; Receptors, Aryl Hydrocarbon; RNA, Small Interfering; Signal Transduction; Time Factors | 2014 |
Antioxidant and renoprotective activity of 2-hydroxypropyl-β-cyclodextrin in nephrectomized rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antioxidants; beta-Cyclodextrins; Biomarkers; Blood Urea Nitrogen; Creatinine; Cytoprotection; Disease Models, Animal; Indican; Indoles; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Oxidation-Reduction; Oxidative Stress; Proton Magnetic Resonance Spectroscopy; Rats; Serum Albumin; Time Factors | 2016 |
Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats.
Topics: Animals; Bone Density; Bone Remodeling; Disease Models, Animal; Indican; Male; Parathyroid Hormone; Parathyroidectomy; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2015 |
The Role of Liver in Determining Serum Colon-Derived Uremic Solutes.
Topics: Aged; Animals; Cohort Studies; Colon; Cresols; Disease Models, Animal; Female; Gastrointestinal Tract; Humans; Indican; Kidney; Linear Models; Liver; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Treatment Outcome; Uremia | 2015 |
Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction.
Topics: Animals; Atrial Fibrillation; Biomarkers; Carbon; Cardiac Pacing, Artificial; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Fibroblasts; Fibrosis; Indican; Inflammation Mediators; Kidney; Male; Myocardium; Nephrectomy; Oxidative Stress; Oxides; Rats, Sprague-Dawley; Risk Factors; Signal Transduction; Time Factors; Uremia | 2015 |
Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure.
Topics: Adenine; Animals; Catechin; CHO Cells; Creatinine; Cresols; Cricetinae; Cricetulus; Disease Models, Animal; Glucuronides; HEK293 Cells; Humans; Indican; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Sulfates; Sulfuric Acid Esters; Tea; Toxins, Biological | 2015 |
Upregulation of nuclear factor-κB activity mediates CYP24 expression and reactive oxygen species production in indoxyl sulfate-induced chronic kidney disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Line, Tumor; Cytochrome P450 Family 24; Cytokines; Deoxyguanosine; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension; Indican; Inflammation Mediators; Kidney; Oxidative Stress; Rats, Inbred Dahl; Reactive Oxygen Species; Renal Insufficiency, Chronic; RNA Interference; Transcription Factor RelA; Transfection; Up-Regulation | 2016 |
Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway.
Topics: Acute Kidney Injury; Aged; Animals; Biomarkers; Cells, Cultured; Disease Models, Animal; E-Selectin; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Indican; Interleukin-1beta; Kidney; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Oxidative Stress; Poisons; Reperfusion Injury; Up-Regulation; Uremia | 2016 |
Indoxyl sulfate suppresses endothelial progenitor cell-mediated neovascularization.
Topics: Angiogenic Proteins; Animals; Bone Marrow Transplantation; Carbon; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothelial Progenitor Cells; Gene Expression Regulation; Hindlimb; Humans; Indican; Inflammation Mediators; Ischemia; Male; Mice, Inbred C57BL; Muscle, Skeletal; Neovascularization, Physiologic; Nephrectomy; Oxides; Regional Blood Flow; Signal Transduction; Time Factors; Transfection; Up-Regulation; Uremia | 2016 |
Identification of key metabolic changes in renal interstitial fibrosis rats using metabonomics and pharmacology.
Topics: Amino Acids, Branched-Chain; Animals; Biomarkers; Disease Models, Animal; Indican; Kidney; Kidney Diseases; Male; Metabolomics; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Sprague-Dawley; Urine | 2016 |
Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1.
Topics: Animals; Antioxidants; Cell Division; Cell Line; Cytokines; Disease Models, Animal; Gene Expression Regulation; Indican; Male; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Myoblasts; Myostatin; Nephrectomy; Organ Size; Organic Anion Transporters; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptors, Aryl Hydrocarbon; Sarcopenia; SKP Cullin F-Box Protein Ligases; Superoxides; Uremia; Weight Loss | 2016 |
Uremic Toxin-Producing Gut Microbiota in Rats with Chronic Kidney Disease.
Topics: Animals; Bacteroidetes; Clostridium; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Indican; Male; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; RNA, Bacterial; RNA, Ribosomal, 16S; Sulfuric Acid Esters; Toxins, Biological | 2017 |
Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease.
Topics: Animals; Disease Models, Animal; Indican; Male; Mice; Muscle, Skeletal; Renal Insufficiency, Chronic; Sarcopenia; Uremia | 2016 |
Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.
Topics: Animal Feed; Animals; Bacteria; Bacteroides; Diet; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Gastrointestinal Tract; Genetic Engineering; Germ-Free Life; Humans; Indican; Indoles; Metagenome; Mice; Microbiota; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Tryptophanase | 2016 |
Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Cresols; Disease Models, Animal; Hippurates; Humans; Indican; Kidney; Kidney Failure, Chronic; Male; Metabolomics; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Sulfuric Acid Esters; Toxins, Biological | 2010 |
Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress.
Topics: Acetophenones; Animals; Carbon; Cell Hypoxia; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Humans; Indican; Indoles; Kidney Failure, Chronic; Kidney Tubules, Proximal; Male; NADPH Oxidases; Nephrectomy; Ouabain; Oxidative Stress; Oxides; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Time Factors; Uremia | 2010 |
Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress.
Topics: Animals; Carbon; Cell Death; Cell Line; Cell Proliferation; Chronic Disease; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Endoplasmic Reticulum; Extracellular Signal-Regulated MAP Kinases; Humans; Indican; Interleukin-6; Kidney Diseases; Kidney Tubules, Proximal; Male; Nephrectomy; Oxides; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Physiological; Transcription Factor CHOP | 2010 |
Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Cell Line, Tumor; Citric Acid; Discriminant Analysis; Disease Models, Animal; Hippurates; Humans; Indican; Ketoglutaric Acids; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methylamines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Principal Component Analysis; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2010 |
Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats.
Topics: Analysis of Variance; Animals; beta-Galactosidase; Cellular Senescence; Disease Models, Animal; Glucuronidase; Hypertension; Indican; Kidney; Klotho Proteins; Rats; Rats, Inbred Dahl; Retinoblastoma Protein | 2011 |
Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model.
Topics: Aconitic Acid; Animals; Disease Models, Animal; Electrophoresis, Capillary; Hippurates; Humans; Indican; Male; Mass Spectrometry; Metabolomics; Polycystic Kidney, Autosomal Dominant; Rats; Renal Insufficiency | 2011 |
Alleviation of cisplatin-induced acute kidney injury using phytochemical polyphenols is accompanied by reduced accumulation of indoxyl sulfate in rats.
Topics: Acute Kidney Injury; Administration, Oral; Animals; Antineoplastic Agents; Biomarkers; Blood Urea Nitrogen; Body Weight; Cell Adhesion Molecules; Cisplatin; Creatinine; Disease Models, Animal; Indican; Kidney; Lipid Peroxidation; Liver; Male; Malondialdehyde; Polyphenols; Quercetin; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Fibrosis; Gene Expression; Humans; Indican; Kidney Tubules, Proximal; Male; Nephrectomy; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; STAT3 Transcription Factor; Uremia | 2012 |
Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure.
Topics: Animals; Aorta; Apoptosis; Blotting, Western; Cell Line; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Glucose; Glucose Transporter Type 1; Hyperplasia; Hypertrophy; Immunohistochemistry; Indican; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nephrectomy; Phloretin; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Renal Insufficiency; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Up-Regulation; Uremia | 2013 |
Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease.
Topics: Animals; Carbon; Cardiovascular Diseases; Cell Line; Disease Models, Animal; Flow Cytometry; Gastrointestinal Agents; Humans; Immunoblotting; Indican; Inflammation; Male; Mice; Mice, Inbred C57BL; Monocytes; Oxides; Reactive Oxygen Species; Renal Insufficiency, Chronic | 2013 |
Pharmacokinetics and tissue distribution of uraemic indoxyl sulphate in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; In Vitro Techniques; Indican; Infusions, Intravenous; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Rats; Rats, Wistar; Tissue Distribution | 2003 |
Hormonal replacement therapy in an animal model with chronic renal failure and gonadectomy: biochemical and hematological study.
Topics: Animals; Creatinine; Disease Models, Animal; Erythrocyte Count; Estradiol; Female; Hematocrit; Hemoglobins; Indican; Kidney Failure, Chronic; Male; Nephrectomy; Orchiectomy; Ovariectomy; Random Allocation; Rats; Rats, Wistar; Testosterone; Urea | 2006 |
Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Blood Urea Nitrogen; Body Temperature; Body Weight; Brain; Carbon; Cell Cycle Proteins; Central Nervous System Diseases; Circadian Rhythm; Cisplatin; Creatinine; Disease Models, Animal; Gastrointestinal Agents; Gene Expression; Indican; Kidney; Kidney Function Tests; Male; Nuclear Proteins; Oxides; Period Circadian Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Suprachiasmatic Nucleus; Time Factors | 2007 |
An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure.
Topics: Administration, Oral; Animals; Antioxidants; Biomarkers; Carbon; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression; Humans; Indican; Kidney Failure, Chronic; Male; Nephrectomy; Organic Anion Transport Protein 1; Oxidation-Reduction; Oxidative Stress; Oxides; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Serum Albumin; Time Factors; Transforming Growth Factor beta1 | 2007 |
Oral sorbent AST-120 increases renal NO synthesis in uremic rats.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Carbon; Creatinine; Disease Models, Animal; Indican; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Nitric Oxide; Nitric Oxide Synthase Type III; Oxides; Rats; Rats, Sprague-Dawley; Reference Values; Uremia | 2008 |
Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats.
Topics: Analysis of Variance; Animals; Aortic Diseases; Blood Pressure; Calcinosis; Core Binding Factors; Disease Models, Animal; Disease Progression; Immunohistochemistry; Indican; Kidney Glomerulus; Organic Anion Transporters, Sodium-Independent; Osteoblasts; Osteopontin; Random Allocation; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary | 2008 |