indican has been researched along with Cirrhosis in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 15 (55.56) | 24.3611 |
| 2020's | 8 (29.63) | 2.80 |
| Authors | Studies |
|---|---|
| Arimura, N; Fujita, I; Fukagawa, M; Imafuku, T; Maeda, H; Maruyama, T; Matsushita, K; Nakano, T; Tanaka, M; Tokumaru, K; Watanabe, H | 1 |
| Cheng, XW; Goto, S; Matsushita, T; Murohara, T; Nakayama, T; Niwa, T; Takeshita, K; Yamaguchi, K; Yisireyili, M | 1 |
| Eiam-Ong, S; Katavetin, P; Leelahavanichkul, A; Panpetch, W; Praditpornsilpa, K; Saisorn, W; Tumwasorn, S; Tungsanga, K; Tungsanga, S; Udompornpitak, K | 1 |
| Janssen, MJ; Masereeuw, R; Mihajlovic, M; Yang, Y | 1 |
| Horikawa, M; Hou, H; Izumi, Y; Jono, H; Kakizoe, Y; Kuwabara, T; Mukoyama, M; Narita, Y; Saito, H | 1 |
| Chang, JF; Chen, YW; Hsieh, CY; Hung, CF; Liang, SS; Lin, CC; Liou, JC; Lu, KC; Wu, MS | 1 |
| Cheng, TH; Hou, YC; Liao, CH; Liao, MT; Liu, WC; Lu, CL; Lu, KC; Ma, MC; Zheng, CM | 1 |
| Bernasconi, H; Díaz-Castillo, ST; Echeverría, G; Fuentealba, J; García-Cancino, A; Jerez-Morales, A; Merino, JS; Smith, CT | 1 |
| Feng, B; Guan, X; He, T; Huang, Y; Li, Y; Liu, Y; Nie, L; Wang, Y; Xiong, J; Xu, X; Yang, K; Yu, Y; Zhang, J; Zhao, J | 1 |
| Lindquist, JA; Mertens, PR; Schneider, A | 1 |
| Cao, L; Fu, Q; Hua, Y; Huang, K; Huang, L; Jucker, BM; Krum, H; Li, Z; Savira, F; Wang, BH; Wang, I; Willette, RN; Yang, W | 1 |
| Asakura, M; Asano, Y; Asanuma, H; Chung, H; Fukuda, H; Funayama, M; Ihara, M; Imazu, M; Ito, S; Kitakaze, M; Min, KD; Minamino, T; Morita, T; Ogai, A; Sugimachi, M; Takahama, H; Takashima, S | 1 |
| Enomoto, A; Nishijima, F; Niwa, T; Saito, S; Shimizu, H; Yisireyili, M | 2 |
| Chang, CH; Hsu, SF; Sun, MF; Wang, WJ; Weng, CS | 1 |
| Aoki, K; Fukui, A; Fukunaga, N; Kondo, H; Nawata, T; Saito, S; Shibata, H; Shimada, T; Takahashi, N; Teshima, Y | 1 |
| Adijiang, A; Bolati, D; Dateki, M; Enomoto, A; Nishijima, F; Niwa, T; Shimizu, H | 1 |
| Schulman, G | 2 |
| Bolati, D; Niwa, T; Shimizu, H | 1 |
| Chang, SC; Sun, CY; Wu, MS | 1 |
| Kelly, DJ; Kompa, AR; Krum, H; Langham, RG; Lekawanvijit, S; Manabe, M; Nishijima, F; Wang, BH | 1 |
| Nishijima, F; Niwa, T; Shimizu, H; Yisireyili, M | 1 |
| Bai, X; Cheng, XL; Lin, RC; Mei, Q; Tan, XJ; Wei, F; Zhao, YY | 1 |
| Horikoshi, S; Ise, M; Kobayashi, N; Maeda, A; Shirato, I; Tomino, Y | 1 |
| Aoyama, I; Niwa, T; Shimokata, K | 2 |
2 review(s) available for indican and Cirrhosis
| Article | Year |
|---|---|
Indoxyl Sulfate, a Tubular Toxin, Contributes to the Development of Chronic Kidney Disease.
Topics: Animals; Cell Death; Fibrosis; Humans; Indican; Kidney; Oxidative Stress; Renal Insufficiency, Chronic; Toxins, Biological; Transforming Growth Factor beta1 | 2020 |
A nexus of progression of chronic kidney disease: tryptophan, profibrotic cytokines, and charcoal.
Topics: Adsorption; Carbon; Disease Progression; Fibrosis; Humans; Indican; Intestinal Absorption; Kidney Failure, Chronic; Microspheres; Oxides; Renin-Angiotensin System; Transforming Growth Factor beta; Tryptophan | 2012 |
1 trial(s) available for indican and Cirrhosis
| Article | Year |
|---|---|
A nexus of progression of chronic kidney disease: charcoal, tryptophan and profibrotic cytokines.
Topics: Administration, Oral; Adult; Aged; Carbon; Cytokines; Endpoint Determination; Female; Fibrosis; Humans; Indican; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Oxides; Tryptophan | 2006 |
24 other study(ies) available for indican and Cirrhosis
| Article | Year |
|---|---|
Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway.
Topics: Cell Line; Epithelial Cells; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Indican; Kidney Diseases; Kidney Tubules; Macrophages; Mechanistic Target of Rapamycin Complex 1; NADPH Oxidases; Ornithine-Oxo-Acid Transaminase; Reactive Oxygen Species; Signal Transduction | 2021 |
Indoxyl Sulfate Activates NLRP3 Inflammasome to Induce Cardiac Contractile Dysfunction Accompanied by Myocardial Fibrosis and Hypertrophy.
Topics: Animals; Cardiomegaly; Cardiomyopathies; Female; Fibrosis; Heart Diseases; Humans; Indican; Inflammasomes; Male; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Inbred Dahl; Renal Insufficiency, Chronic | 2022 |
Lactobacillus rhamnosus L34 attenuates chronic kidney disease progression in a 5/6 nephrectomy mouse model through the excretion of anti-inflammatory molecules.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Culture Media, Conditioned; Disease Models, Animal; Fibrosis; Humans; Indican; Inflammation; Lacticaseibacillus rhamnosus; Mice; Nephrectomy; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha | 2022 |
The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells.
Topics: Epithelial Cells; Fibrosis; Humans; Indican; Kidney Tubules, Proximal; Uremic Toxins | 2023 |
Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice.
Topics: Animals; Disease Models, Animal; Erythropoietin; Fibrosis; Humans; Indican; Inflammation; Kidney; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic; Sulfotransferases; Ureteral Obstruction | 2023 |
Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease.
Topics: Animals; Aristolochic Acids; Cresols; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Indican; JNK Mitogen-Activated Protein Kinases; Kidney Tubules; Mice, Inbred C57BL; Propolis; Renal Insufficiency, Chronic; Signal Transduction; Smad2 Protein; Smad3 Protein; Sulfuric Acid Esters; Transforming Growth Factor beta; Uremia | 2020 |
The Administration of the Synbiotic
Topics: Animals; Creatinine; Disease Models, Animal; Disease Progression; Female; Fibrosis; Heart Diseases; Indican; Inulin; Kidney; Lactobacillus delbrueckii; Myocardium; Oligosaccharides; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Synbiotics; Toxins, Biological | 2021 |
DNA hypermethylation of sFRP5 contributes to indoxyl sulfate-induced renal fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; DNA Methylation; Eye Proteins; Fibrosis; Humans; Indican; Kidney; MAP Kinase Signaling System; Membrane Proteins; Reactive Oxygen Species; Renal Insufficiency, Chronic; Wnt Signaling Pathway | 2017 |
Regulation of endogenous brakes to kidney fibrosis: turning the view upside down.
Topics: Adaptor Proteins, Signal Transducing; DNA; Eye Proteins; Fibrosis; Humans; Indican; Membrane Proteins | 2017 |
Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome.
Topics: Animals; Cardio-Renal Syndrome; Cardiomegaly; Cells, Cultured; Cresols; Fibrosis; Indican; MAP Kinase Kinase Kinase 5; Mitogen-Activated Protein Kinases; NF-kappa B; Protein Kinase Inhibitors; Rats; Sulfuric Acid Esters; Toxins, Biological | 2017 |
AST-120, an Adsorbent of Uremic Toxins, Improves the Pathophysiology of Heart Failure in Conscious Dogs.
Topics: Adsorption; Animals; Apoptosis; Apoptosis Regulatory Proteins; Carbon; Cardio-Renal Syndrome; Consciousness; Disease Models, Animal; Dogs; Fibrosis; Heart Failure; Hemodynamics; Indican; Kidney Diseases; Mitochondria, Heart; Myocardium; Oxides; Signal Transduction; Sorption Detoxification; Uremia; Ventricular Function, Left | 2019 |
Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats.
Topics: Animals; Cardiomegaly; Fibrosis; Hypertension; Indican; Oxidative Stress; Random Allocation; Rats; Rats, Inbred Dahl | 2013 |
Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.
Topics: Actins; Animals; Carbon; Cell Line; Chelating Agents; Disease Models, Animal; Fibrosis; Humans; Hypertension, Renal; Indican; Kidney Tubules, Proximal; Male; Oxides; Prorenin Receptor; Random Allocation; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Renal Insufficiency, Chronic; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Transforming Growth Factor beta1; Up-Regulation | 2014 |
DPP-4 inhibitor attenuates toxic effects of indoxyl sulfate on kidney tubular cells.
Topics: Apoptosis; Caspase 3; Cell Line; Cell Survival; Cytosol; Dipeptidyl-Peptidase IV Inhibitors; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Humans; Indican; Kidney Tubules, Proximal; MAP Kinase Signaling System; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Transcription Factor RelA; Transforming Growth Factor beta | 2014 |
Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal Dysfunction.
Topics: Animals; Atrial Fibrillation; Biomarkers; Carbon; Cardiac Pacing, Artificial; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Fibroblasts; Fibrosis; Indican; Inflammation Mediators; Kidney; Male; Myocardium; Nephrectomy; Oxidative Stress; Oxides; Rats, Sprague-Dawley; Risk Factors; Signal Transduction; Time Factors; Uremia | 2015 |
Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.
Topics: Acetylcysteine; Animals; Benzothiazoles; Cell Line; Cell Proliferation; Cellular Senescence; Fibrosis; Humans; Indican; Kidney Failure, Chronic; Kidney Tubules, Proximal; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Toluene; Tumor Suppressor Protein p53 | 2010 |
AST-120 ameliorates epithelial-to-mesenchymal transition and interstitial fibrosis in the kidneys of chronic kidney disease rats.
Topics: Actins; Adsorption; Animals; Carbon; Cell Movement; Epithelial Cells; Fibrosis; Immunohistochemistry; Indican; Kidney; Kidney Failure, Chronic; Male; Membrane Proteins; Oxides; Phosphoproteins; Rats; Rats, Sprague-Dawley; Zonula Occludens-1 Protein | 2012 |
Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition.
Topics: Angiotensinogen; Animals; Cresols; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression Regulation; Indican; Kidney; Kidney Failure, Chronic; Kidney Tubules; Losartan; Male; Mice; Models, Biological; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Snail Family Transcription Factors; Sulfuric Acid Esters; Transcription Factors; Transforming Growth Factor beta1; Uremia | 2012 |
Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate.
Topics: Animals; Carbon; Cardiomyopathies; Fibrosis; Indican; Male; Oxides; Random Allocation; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2012 |
Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence.
Topics: Acute Kidney Injury; Animals; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Fibrosis; Gene Expression; Humans; Indican; Kidney Tubules, Proximal; Male; Nephrectomy; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; STAT3 Transcription Factor; Uremia | 2012 |
Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MS(E).
Topics: Adenine; Animals; Chromatography, High Pressure Liquid; Cresols; Fatty Acids, Unsaturated; Fibrosis; Gene Expression; Indican; Kidney Function Tests; Kidney Tubules; Male; Metabolome; Rats; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Tandem Mass Spectrometry; Transforming Growth Factor beta1 | 2013 |
Effects of oral adsorbent AST-120 (Kremezin) on renal function and glomerular injury in early-stage renal failure of subtotal nephrectomized rats.
Topics: Adsorption; Animals; Blood Pressure; Blood Urea Nitrogen; Carbon; Creatinine; Fibrosis; Indican; Kidney; Kidney Glomerulus; Male; Nephrectomy; Oxides; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Sclerosis | 2002 |
An oral adsorbent downregulates renal expression of genes that promote interstitial inflammation and fibrosis in diabetic rats.
Topics: Administration, Oral; Adsorption; Animals; Blotting, Northern; Carbon; Chemokine CCL2; Clusterin; Diabetic Nephropathies; Fibrosis; Gene Expression; Glycoproteins; Immunohistochemistry; Indican; Intercellular Adhesion Molecule-1; Kidney; Male; Molecular Chaperones; Osteopontin; Oxides; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Combination therapy with benazepril and oral adsorbent ameliorates progressive renal fibrosis in uremic rats.
Topics: Adsorption; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Carbon; Cells, Cultured; Disease Progression; Drug Therapy, Combination; Fibroblasts; Fibrosis; Humans; In Situ Hybridization; Indican; Kidney; Kidney Diseases; Male; Nephrectomy; Nephrosclerosis; Osteopontin; Oxides; Rats; Rats, Sprague-Dawley; Sialoglycoproteins; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Transforming Growth Factor beta1; Uremia | 2002 |