indican has been researched along with Chronic Kidney Diseases in 254 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 134 (52.76) | 24.3611 |
| 2020's | 120 (47.24) | 2.80 |
| Authors | Studies |
|---|---|
| Borges, NA; Capo-Chichi, JCC; de Vargas Reis, DCM; Mafra, D; Nakao, LS | 1 |
| Cetinkaya, MA; Kepekci-Tekkeli, SE; Kul, O; Melekoglu, E; Samur, G | 1 |
| Brigant, B; Choukroun, G; Diouf, M; Fourdinier, O; Glorieux, G; Group-EUTox, OBOTEUTW; Massy, ZA; Metzinger, L; Metzinger-Le Meuth, V; Pletinck, A; Vanholder, R; Verbeke, F | 1 |
| Chariyavilaskul, P; Eiam-Ong, S; Katavetin, P; Leelahavanichkul, A; Phannajit, J; Praditpornsilpa, K; Puapatanakul, P; Sitticharoenchai, P; Sukkumme, W; Susantitaphong, P; Takkavatakarn, K | 1 |
| Aljama, P; Carmona, A; Guerrero, F; Jimenez, MJ; Martín-Malo, A; Moreno, JA; Obrero, T; Pulido, V; Soriano, S | 1 |
| Chang, CT; Chen, YC; Fang, TC; Hou, YC; Liao, TY; Liu, WC; Lu, KC; Shyu, JF; Zheng, CM | 1 |
| Arinze, N; Belghasem, M; Chitalia, VC; Dember, LM; Lee, N; Lotfollahzadeh, S; Napoleon, MA; Ravid, K; Richards, S; Russell, TL; Walker, JA; Whelan, SA; Yoo, SB | 1 |
| Carriazo, S; Franssen, CFM; Gansevoort, RT; Gesualdo, L; Hafez, G; Liabeuf, S; Malyszko, J; Massy, ZA; Mayer, C; Nitsch, D; Ortiz, A; Pepin, M; Pešić, V; Viggiano, D; Wiecek, A | 1 |
| Guo, X; He, S; Li, L; Liang, W; Lin, X; Wang, H; Xiang, S; Xiong, Q; Yao, Y; Ying, C; Zhang, P; Zhao, J; Zuo, X | 1 |
| Anderson, S; Arinze, NV; Belghasem, M; Chitalia, VC; Farber, A; Francis, J; Hamburg, NM; Hassan Kamel, M; Lee, N; Lotfollahzadeh, S; Napoleon, MA; Rahimi, N; Ravid, JD; Richards, S; Sherr, D; Siracuse, JJ; Walker, JA; Whelan, SA; Yin, W | 1 |
| Campbell, KL; Johnson, DW; Krishnasamy, R; McFarlane, C; Mihala, G; Morrison, M; Savill, E; Snelson, M; Stanton, T | 1 |
| Chao, CT; Chen, JH; Chiang, CK; Huang, JW; Hung, KY; Liu, SH; Tarng, DC | 1 |
| Chen, L; Ma, X; Qu, H; Shi, D; Shi, J | 1 |
| Beckert, J; Fick, S; Fiedler, R; Girndt, M; Kneser, L; Markau, S; Schäfer, C; Seibert, E; Trojanowicz, B; Ulrich, C; Wildgrube, S | 1 |
| Chang, CH; Chang, KT; Huang, YC; Ko, PH; Lai, LC; Tsai, TC | 1 |
| Berg, AH; Karumanchi, SA; Kumar, S | 1 |
| Cheng, XW; Goto, S; Matsushita, T; Murohara, T; Nakayama, T; Niwa, T; Takeshita, K; Yamaguchi, K; Yisireyili, M | 1 |
| Li, H; Yang, J; Zhang, C; Zhou, Y | 1 |
| Eiam-Ong, S; Katavetin, P; Leelahavanichkul, A; Panpetch, W; Praditpornsilpa, K; Saisorn, W; Tumwasorn, S; Tungsanga, K; Tungsanga, S; Udompornpitak, K | 1 |
| Bataille, S; Brunet, P; Burtey, S; Dou, L; Fraisse, M; Lano, G; McKay, N; Pelletier, M; Sallée, M | 1 |
| Edgley, AJ; Kelly, DJ; Kompa, AR; Nguyen, C | 1 |
| Burtey, S; Cerini, C; McKay, N; Poitevin, S; Vial, R | 1 |
| de Azevedo, MLV; Favretto, G; Franco, CRC; Gonçalves, JP; Gregório, PC; Maciel, RAP; Pecoits-Filho, R; Stafim da Cunha, R; Stinghen, AEM | 1 |
| Gil, HW; Kim, DS; Kim, SW | 1 |
| Donouchi, M; Kamada, S; Kanda, M; Kobuchi, S; Matsumura, Y; Nakagawa, K; Ohkita, M; Tanaka, R; Tawa, M | 1 |
| Burtey, S; Glorieux, G; Nigam, SK; Vanholder, R | 1 |
| Aniort, J; Bartoli, M; Bataille, S; Burtey, S; Chermiti, R; Da Silva, N; Dou, L; Ferkak, B; McKay, N; Poitevin, S; Sallée, M | 1 |
| Hu, D; Li, C; Peng, A; Wang, Q; Xue, W; Yu, H; Zhou, C | 1 |
| Hosoda, Y; Miyazaki, M; Mori, T; Sato, E; Sato, H; Sekimoto, A; Takahashi, N; Todoriki, S; Watanabe, M; Yamamoto, T | 1 |
| Duan, X; Gao, Y; Li, Y; Wang, Q; Zhang, H | 1 |
| Abdelrasoul, A; Daneshamouz, S; Eduok, U; Shoker, A | 1 |
| Bagnati, M; Carrera, D; Chiarinotti, D; De Mauri, A; Riso, S; Rolla, R; Torreggiani, M; Vidali, M | 1 |
| Chitchongyingcharoen, N; Duangchan, T; Korpraphong, S; Mas-Oodi, S; Promkan, M; Rattanasompattikul, M; Rongkiettechakorn, N; Supokawej, A | 1 |
| Fujita, K; Ichida, K; Kutsuno, R; Nonaka, T | 1 |
| Gwozdzinski, K; Gwozdzinski, L; Kopera, M; Pieniazek, A | 1 |
| Altomare, A; Astori, E; Colombo, G; Dalle-Donne, I; Gagliano, N; Garavaglia, ML; Giustarini, D; Landoni, L; Lionetti, MC; Milzani, A; Rossi, R | 1 |
| Hsieh, TH; Huang, PH; Li, SY; Lin, FY; Lin, SJ; Yang, SF | 1 |
| Koppe, L; Soulage, CO | 1 |
| Chen, YL; Chien, YC; Pan, YR; Wei, CW; Wu, JY; Wu, SC; Wu, TK; Yiang, GT; Yu, YL | 1 |
| Dimković, N; Golić, N; Mitrović, M; Nastasijević, B; Soković Bajić, S; Soldatović, I; Stanković-Popović, V; Svorcan, P; Tolinački, M; Veljović, K | 1 |
| Bouchouareb, D; Brunet, P; Burtey, S; Dou, L; Ebersolt, M; Mallmann, C; Mc-Kay, N; Sallée, M; Santana Machado, T | 1 |
| Garssen, J; Madella, AM; Masereeuw, R; Overbeek, SA; Van Bergenhenegouwen, J | 1 |
| Gupta, A; Jacob, C; Mahaldar, A; Rajagopal, A; Saxena, A; Srinivasa, S; Veerappan, I | 1 |
| Chen, X; Jiang, H; Lu, S; Ma, Z; Xu, S; Yang, X; Zhang, Y; Zhao, J; Zhou, H | 1 |
| An, WS; Cha, RH; Han, MY; Kang, SH; Kim, JC; Kim, SH; Lee, SM | 1 |
| Chen, C; He, W; Sun, S; Sun, W; Wu, Q; Zhao, J | 1 |
| Barreiros, L; Campagnolo, S; Fernandes, SR; Marques, SS; Sampaio-Maia, B; Segundo, MA; Silva, LAP | 1 |
| Li, YY; Ma, YM; Nie, ZB; Wang, YH; Zhang, R; Zhang, XQ | 1 |
| Alvarez, JC; Choukroun, G; García-Caballero, C; Garçon, L; Guerrero-Hue, M; Hamza, E; Larabi, IA; Massy, ZA; Metzinger, L; Meuth, VM; Moreno, JA; Ouled-Haddou, H; Rayego-Mateos, S; Santier, L; Vallejo-Mudarra, M | 1 |
| Hu, D; Ji, C; Li, Y; Liu, X; Lu, Z; Mo, Y; Yu, W | 1 |
| Addipilli, R; Babi Reddy Gari, AR; Chirra, N; Kantevari, S; Ketavarapu, V; Lingampelly, SS; Pallerla, P; Ragi, N; Sripadi, P; Yadla, M | 1 |
| Arefin, S; de Loor, H; Ebert, T; Evenepoel, P; Hernandez, L; Hobson, S; Kublickiene, K; Rahman, A; Stenvinkel, P | 1 |
| Amodio, L; Caggiano, G; Colabufo, NA; Colangiulo, S; Gesualdo, L; Pesce, F; Stasi, A | 1 |
| Chen, Y; Jin, H; Li, R; Li, Y; Wei, J; Zhang, P; Zhang, Z | 1 |
| Dębska-Ślizień, A; Ruszkowski, J | 1 |
| Abate, M; Capasso, A; Capasso, G; Caraglia, M; De, A; Di Paola, R; Izhar, R; La Russa, A; Perna, AF; Simeoni, M; Zappavigna, S | 1 |
| Chang, L; Guo, Z; He, L; Li, Y; Tian, R; Xu, Y; Zhang, H | 1 |
| Huang, L; Liu, L; Liu, XY; Liu, YF; Lu, C; Tang, MY; Wu, L; Zhang, C | 1 |
| Horikawa, M; Hou, H; Izumi, Y; Jono, H; Kakizoe, Y; Kuwabara, T; Mukoyama, M; Narita, Y; Saito, H | 1 |
| Ando, T; Itoh, H; Oda, A; Ohno, K; Ono, H; Sato, H; Shin, T; Suzuki, Y; Tanaka, R; Tatsuta, R; Yoshijima, C | 1 |
| Cao, X; Flaherty, DP; Graboski, AL; Ha, M; Kowalewski, ME; Redinbo, MR; Simpson, JB; Walton, WG; Zhang, J | 1 |
| Chan, S; Cooper, TE; Craig, JC; Hawley, CM; Howell, M; Jaure, A; Johnson, DW; Khalid, R; Teixeira-Pinto, A; Wong, G | 1 |
| Fischer, D; Gründemann, D; Müller, JP; Tust, M | 1 |
| Alvarez, JC; Bénard, A; Catros, S; Combe, C; Larabi, I; Massy, Z; Quintin, O; Rigothier, C; Samot, J | 1 |
| Anarat, A; Anninos, A; Azukaitis, K; Balat, A; Bayazit, A; Bilginer, Y; Bulut, IK; Cakar, N; Caliskan, S; Candan, C; Canpolat, N; Duzova, A; Ertan, P; Habbig, S; Harambat, J; Holle, J; Kirchner, M; Kranz, B; Melk, A; Niemirska, A; Okun, J; Özcakar, ZB; Querfeld, U; Schaefer, F; Shroff, R; Soylemezoglu, O; Thurn-Valsassina, D; Tschumi, S; Yilmaz, E; Zurowska, A | 1 |
| Chen, L; Gao, F; He, X; Jiang, H; Liang, S; Wei, M | 1 |
| Enoki, Y; Maruyama, T; Watanabe, H | 1 |
| Fedecostante, M; Galetin, A; Gerritsen, KG; Hoenderop, JGJ; Jankowski, J; Jankowski, V; Koster, AS; Masereeuw, R; Middel, I; Rostami-Hodjegan, A; Sastre Toraño, J; Scotcher, D; van der Made, TK | 1 |
| Hsu, BG; Kuo, CH; Lai, YH; Lin, YL; Tsai, JP; Wang, CH | 1 |
| Ieda, M; Tajiri, K; Yamagami, F; Yumino, D | 1 |
| Isaiah, A; Lidbury, JA; Phillips, RK; Quimby, JM; Steiner, JM; Stockman, J; Suchodolski, J; Summers, S | 1 |
| Assefa, EG; Gezahegn, SB; He, S; Salissou, MTM; Wu, N; Yan, Q; Ying, C; Zuo, X | 1 |
| Hsu, YL; Hwang, SJ; Kuo, MC; Kuo, PL; Liang, SS; Lin, YT; Mubanga, M; Wu, PH; Yang, YH | 1 |
| Arinze, N; Belghasem, ME; Chitalia, VC; Francis, J; Kolachalama, VB; Lee, N; Ravid, K; Richards, S; Sherr, D; Tashjian, JY; Walker, JA; Whelan, SA; Yoo, SB | 1 |
| Fujino, T; Ikeda, T; Kinoshita, T; Koike, H; Morita, T; Shinohara, M; Suzuki, T; Tatebe, J; Watanabe, I; Yuzawa, H | 1 |
| D'Haese, PC; Opdebeeck, B; Verhulst, A | 1 |
| Chang, LC; Chen, YC; Chiu, CY; Chung, WH; Gao, SS; Hsieh, WP; Hsu, HJ; Kuo, YL; Lai, HC; Lee, CC; Lin, CY; Su, SC; Sun, CY; Wu, IW; Yang, CW | 1 |
| Lin, CJ; Lin, FH; Sun, CY; Wu, CC; Wu, CJ; Wu, V | 1 |
| Adoberg, A; Arduan Ortiz, A; Arund, J; Dhondt, A; Fernström, A; Fridolin, I; Glorieux, G; Gonzalez-Parra, E; Leis, L; Luman, M; Paats, J; Perez-Gomez, VM; Pilt, K; Sanchez-Ospina, D; Segelmark, M; Uhlin, F | 1 |
| Glorieux, G; Gryp, T; Huys, GRB; Joossens, M; Van Biesen, W; Vaneechoutte, M | 1 |
| Addi, T; Brunet, P; Burtey, S; Dou, L; Laforêt, M; Lano, G; Perrin, J; Poitevin, S; Von Kotze, C | 1 |
| Burtey, S; Lano, G; Sallée, M | 1 |
| Huang, PH; Liou, JY; Shih, YC; Tarng, DC; Wang, SC; Wu, CC | 1 |
| Iguchi, A; Ishioka, K; Kazama, JJ; Narita, I; Oda, A; Saeki, T; Suzutani, T; Tanaka, K; Yamamoto, S; Yamazaki, H | 1 |
| Burtey, S; Corbeau, P; Cristol, JP; Dunyach-Remy, C; Lavigne, JP; Moranne, O; Olivier, V; Sutra, T | 1 |
| Couttenye, MM; De Paepe, K; Glorieux, G; Gryp, T; Joossens, M; Kerckhof, FM; Speeckaert, M; Van Biesen, W; Van de Wiele, T; Vaneechoutte, M; Vanholder, R; Verbeke, F | 1 |
| Espi, M; Fouque, D; Koppe, L; Thaunat, O | 1 |
| Chang, Y; Lau, WL; Vaziri, ND | 1 |
| Chang, JF; Chen, YW; Hsieh, CY; Hung, CF; Liang, SS; Lin, CC; Liou, JC; Lu, KC; Wu, MS | 1 |
| Hermanowicz, JM; Kalaska, B; Kaminski, TW; Karbowska, M; Nosek, K; Pawlak, D; Tankiewicz-Kwedlo, A; Wisniewska, RJ | 1 |
| Flissi, N; Gallet, M; Kamel, S; Lenglet, G; Liabeuf, S; Louvet, L; Massy, ZA; Six, I | 1 |
| Bi, X; Chen, Y; Han, W; He, T; Huang, Y; Li, Y; Liu, Y; Qiao, Y; Wang, S; Xiao, T; Xiong, J; Yang, K; Yu, Y; Zhao, J; Zhou, J | 1 |
| Benkowitz, P; Cheng, Y; Köttgen, A; Lamina, C; Li, Y; Sekula, P | 1 |
| Choi, HY; Han, SW; Jhee, JH; Jo, YI; Kim, SH; Lee, SH; Lee, SY; Park, HC; Shin, SK; Yang, DH; Yi, JH | 1 |
| Cuppari, L; Dalboni, MA; de Andrade, LS; de Lima, JD; Nakao, LS; Pereira, NBF; Ramos, CI; Rodrigues, SD; Teixeira, RR | 1 |
| Arimura, N; Enoki, Y; Fukagawa, M; Imafuku, T; Kato, H; Maeda, H; Maruyama, T; Matsushita, K; Nakano, T; Tanaka, M; Tanaka, S; Tokumaru, K; Watanabe, H | 1 |
| Kuo, WH; Lee, CT; Lee, YT; Leung, FF; Ng, HY; Tain, YL | 1 |
| Al Salam, S; Al Suleimani, Y; Al Za'abi, M; Ali, BH; Ashique, M; Manoj, P; Nemmar, A | 1 |
| Cao, YG; Fenn, K; Garrett, WS; Glickman, JN; Lobel, L | 1 |
| Chen, L; Cheng, X; Gao, F; He, X; Jiang, H; Wang, Z; Wei, L | 1 |
| ALanazi, AG; Ali, I; ALOthman, ZA | 1 |
| Chen, C; Duan, J; Guo, J; Jiang, S; Li, J; Lu, J; Peng, Y; Wang, Y; Xu, X; Yu, J; Zhang, S | 1 |
| Chen, PH; Chiu, HW; Hou, YC; Lim, PS; Lin, YF; Liu, WC; Lu, CL; Lu, KC; Shyu, JF; Zheng, CM | 1 |
| Azukaitis, K; Baskin, E; Bayazit, AK; Bulut, IK; Büscher, R; Candan, C; Canpolat, N; Drozdz, D; Duzova, A; Erdogan, H; Gimpel, C; Holle, J; Jankauskiene, A; Kirchner, M; Klaus, G; Lugani, F; Melk, A; Nobili, F; Obrycki, L; Oh, J; Okun, J; Özcelik, G; Querfeld, U; Ranchin, B; Schaefer, F; Shroff, R; Yilmaz, A; Zaloszyc, A | 1 |
| Al-Kassou, B; Böhm, M; Düsing, P; Goody, PR; Hosen, MR; Jamme, P; Jansen, F; Liu, W; Nickenig, G; Niepmann, S; Pfeifer, A; Reiners, KS; Steffen, E; Werner, N; Zietzer, A; Zimmer, S | 1 |
| Cheng, TH; Hou, YC; Liao, CH; Liao, MT; Liu, WC; Lu, CL; Lu, KC; Ma, MC; Zheng, CM | 1 |
| Chao, CT; Lin, SH | 1 |
| Han, SY; Jeong, KH; Kang, DH; Kee, YK; Kim, BS; Kim, GH; Kim, YW; Noh, JW | 1 |
| Bansal, N; Chen, Y; Feldman, HI; Go, AS; Heckbert, SR; Hoofnagle, AN; Hsu, CY; Huber, MP; Kestenbaum, BR; Lash, JP; Mehta, RC; Paranji, RK; Porter, AC; Raj, DS; Seliger, SL; Srivastava, A; Waikar, SS; Wang, K; Weiss, NS; Zelnick, LR | 1 |
| Ho, LC; Hung, SY; Lin, TM; Liou, HH; Wu, TY | 1 |
| Chen, TW; Huang, HD; Liang, SS; Lu, WL; Tarng, DC; Tseng, CP; Yang, CY | 1 |
| Anansilp, K; Kamprom, W; Mas-Oodi, S; Rattanasompattikul, M; Supokawej, A; Tawonsawatruk, T | 1 |
| Chen, C; Mao, H; Wu, L; Xie, C; Xing, C; Zhao, X | 1 |
| Eiam-Ong, S; Phannajit, J; Praditpornsilpa, K; Susantitaphong, P; Takkavatakarn, K; Wuttiputinun, T | 1 |
| Autore, G; Dal Piaz, F; Di Iorio, BR; Iovane, V; Marzocco, S; Nishijima, F; Paciello, O; Popolo, A; Prisco, F; Rapa, SF | 1 |
| De Bacquer, D; Glorieux, G; Neirynck, N; Pletinck, A; Schepers, E; Speeckaert, M; Van Biesen, W; Vanholder, R; Verbeke, F | 1 |
| Armelloni, S; Caldiroli, L; Cesari, M; Eskander, A; Margiotta, E; Messa, P; Rizzo, V; Vettoretti, S | 1 |
| Domon, M; Goto, S; Goto, Y; Ito, T; Narita, I; Sasahara, K; Yamaguchi, K; Yamamoto, S | 1 |
| Baldanzi, G; Chen, SC; Chiu, YW; Hsu, YL; Huang, JC; Hwang, SJ; Kuo, MC; Lee, SC; Liang, SS; Lin, YT; Wu, PH | 1 |
| Chen, CJ; Li, JR; Liao, SL; Lin, CJ; Lin, SY; Ou, YC; Sun, CY; Wang, JD; Wang, YY | 1 |
| Bernasconi, H; Díaz-Castillo, ST; Echeverría, G; Fuentealba, J; García-Cancino, A; Jerez-Morales, A; Merino, JS; Smith, CT | 1 |
| Hsu, BG; Lai, YH; Liu, CH; Tsai, JP; Wang, CH; Wang, SC | 1 |
| Cosola, C; Gesualdo, L; Ranieri, E; Rocchetti, MT | 1 |
| Acquaviva, PM; Corciulo, S; Cosola, C; De Angelis, M; di Bari, I; Di Ciaula, A; Di Palo, DM; Fontana, S; Gesualdo, L; La Forgia, FM; Maranzano, V; Portincasa, P; Rocchetti, MT | 1 |
| Armelloni, S; Caldiroli, L; Callegari, ML; Margiotta, E; Messa, P; Miragoli, F; Rizzo, V; Vettoretti, S; Zanoni, F | 1 |
| Chang, JF; Chang, SW; Hsieh, CY; Liou, JC; Lu, KC; Wang, TM; Wu, CC; Wu, MS; Zheng, CM | 1 |
| Lee, S; Mair, RD; Meyer, TW; Plummer, NS; Sirich, TL | 1 |
| Barreto, DV; Barreto, FC; Massy, ZA; Stinghen, AEM | 1 |
| Al Kalbani, J; Al Suleimani, Y; Al Za'abi, M; Ali, BH; Ashique, M; Karaca, T; Nemmar, A | 1 |
| Borges, NA; Brito, JS; Esgalhado, M; Mafra, D; Magliano, DC; Soulage, CO | 1 |
| Feng, B; Guan, X; He, T; Huang, Y; Li, Y; Liu, Y; Nie, L; Wang, Y; Xiong, J; Xu, X; Yang, K; Yu, Y; Zhang, J; Zhao, J | 1 |
| de Loor, H; Deltombe, O; Dhondt, A; Eloot, S; Glorieux, G; Meijers, B; Van Biesen, W | 1 |
| Arake, R; Enoki, Y; Fujimura, R; Fukagawa, M; Imafuku, T; Ishima, Y; Ishiodori, K; Komaba, H; Maruyama, T; Matsushita, K; Miyamura, S; Nagao, S; Nishida, K; Otagiri, M; Sugimoto, R; Tanaka, M; Watanabe, H | 1 |
| Bataille, S; Berland, Y; Brunet, P; Burtey, S; Duval, A; Gentile, S; McKay, N; Mouelhi, Y; Pelletier, M; Sallée, M | 1 |
| Gao, H; Liu, S | 1 |
| Kamiński, T; Michałowska, M; Pawlak, D | 1 |
| Hamano, H; Horinouchi, Y; Ikeda, Y; Imanishi, M; Ishizawa, K; Izawa-Ishizawa, Y; Miyamoto, L; Takechi, K; Tamaki, T; Tsuchiya, K; Watanabe, H; Zamami, Y | 1 |
| Delrue, W; Dhondt, A; Eloot, S; Glorieux, G; Roels, S; Schepers, E; Van Biesen, W; Vanholder, R | 1 |
| Brunet, P; Burtey, S; Cerini, C; Dignat-George, F; Jourde-Chiche, N; Legris, T; Masereeuw, R; McKay, N; Mouly-Bandini, A; Paul, P; Poitevin, S; Santana Machado, T | 1 |
| Alousi, F; Belghasem, ME; Chang, GH; Chitalia, VC; Dember, LM; Francis, JM; Gibson, CM; Kolachalama, VB; Matsuura, S; Ravid, K; Rijal, K; Shashar, M; Shivanna, S; Walker, J | 1 |
| Addi, T; Brunet, P; Burtey, S; Cerini, C; Denison, MS; Dignat-George, F; Dou, L; Duval-Sabatier, A; Gondouin, B; Jourde-Chiche, N; McKay, N; Poitevin, S; Sallée, M | 1 |
| Chen, CN; Chou, CC; Lee, YJ; Tsai, PSJ | 1 |
| Anjos, JS; Black, AP; Cardozo, L; Carmo, FL; Carraro Eduardo, JC; de Carvalho Ferreira, D; Dolenga, CJ; Mafra, D; Nakao, LS; Rosado, A | 1 |
| Berg, AH; Clish, C; Goldstein, MB; Kalim, S; Kiaii, M; Perl, J; Rhee, EP; Thadhani, R; Wald, R; Xu, D; Yan, AT | 1 |
| Li, DY; Tang, WHW | 1 |
| Aoki, J; Asami, M; Horiuchi, Y; Ito, S; Tanabe, K; Tanimoto, S; Yoshida, E; Yoshida, M | 1 |
| Chillon, JM; Hénaut, L; Kamel, S; Massy, ZA | 1 |
| Yamamoto, S | 1 |
| Agatsuma, Y; Kakinuma, C; Kashiwagura, S; Miyamoto, M; Morimoto, K; Ogihara, T; Sano, Y; Takahashi, A; Tominaga, Y; Tomita, M; Yano, K | 1 |
| Fujimori, S; Higashino, T; Ichida, K; Matsuo, H; Miyata, H; Nakashima, A; Nakayama, A; Ooyama, H; Ooyama, K; Sakiyama, M; Shinomiya, N; Suzuki, H; Takada, T; Tan, JK; Toyoda, Y; Yamamoto, T; Yamanashi, Y | 1 |
| Adkins, NS; Bartlett, DE; Bown, PC; Cottrill, CL; D Pratt, R; Khanal, T; Klug, RL; Lakhani, HV; Miller, RB; Nease, DB; Shapiro, JI; Sodhi, K; Thiesfeldt, S | 1 |
| Asai, H; Hirata, J; Watanabe-Akanuma, M | 1 |
| Liu, WC; Lu, KC; Tomino, Y | 1 |
| Cai, X; Li, X; Lin, J; Scott, EM; Wu, M; Zhang, X | 1 |
| Tarng, DC; Yang, CY | 1 |
| Boullier, A; Busato, V; Cunha, RS; Dolenga, CJR; Franco, CRC; Gregório, PC; Maciel, RAP; Massy, ZA; Nakao, LS; Pecoits-Filho, R; Stinghen, AEM | 1 |
| Fujino, T; Ikeda, T; Koike, H; Koike, M; Morita, T; Shinohara, M; Suzuki, T; Tatebe, J; Watanabe, I; Yao, S; Yuzawa, H | 1 |
| Azevedo, R; Borges, NA; Dolenga, CJ; Esgalhado, M; Kemp, JA; Mafra, D; Nakao, LS; Paiva, BR; Stockler-Pinto, MB | 1 |
| Bennis, Y; Bouabdallah, J; Caus, T; Choukroun, G; Issa, H; Kamel, S; Kchour, G; Lenglet, G; Six, I; Zibara, K | 1 |
| Gustafson, DL; Isaiah, A; Lunghofer, PJ; Quimby, JM; Suchodolski, JS; Summers, SC | 1 |
| Chinnappa, S; Glorieux, G; Mooney, A; Tu, YK; Vanholder, R; Yeh, YC | 1 |
| Aikawa, E; Aikawa, M; Anderson, DG; Aster, JC; Barabási, AL; Boff, MS; Chen, M; Decano, JL; Golden, WS; Guimaraes, GC; Halu, A; Higashi, H; Iwata, H; Katsuki, S; Kauffman, KJ; Kum, AST; Kuromoto, RK; Lee, LH; Maejima, T; Nakano, T; Pestana, DVS; Sharma, A; Singh, SA; Suzuki, T | 1 |
| Kaminski, TW; Karbowska, M; Mor, AL; Mysliwiec, M; Pawlak, D; Pawlak, K; Znorko, B | 1 |
| Gomółka, M; Jasik, M; Niemczyk, L; Niemczyk, S; Pączek, L; Rymarz, A; Smoszna, J; Szamotulska, K; Wyczałkowska-Tomasik, A | 1 |
| da Silva, BP; de Castro Moreira, ME; Hermsdorff, HH; Lopes, RCSO; Mantovani, HC; Martino, HSD; Queiroz, VAV; Theodoro, JMV | 1 |
| Cao, W; Duan, J; Guo, J; Leng, J; Li, J; Shang, E; Shen, Z; Wang, N; Wang, Y; Xu, X; Zhu, Z; Zou, N | 1 |
| Chou, CC; Lee, YJ; Liao, YL | 1 |
| Chang, JC; Chen, YC; Chen, YT; Chu, PH; Fan, PC; Kou, G; Lee, CC; Lin, CN; Lu, YA; Yang, CW | 1 |
| Azmi, A; D'Haese, PC; De Leger, W; De Maré, A; Evenepoel, P; Maudsley, S; Meijers, B; Neven, E; Opdebeeck, B; Verhulst, A | 1 |
| Armani, RG; Campbell, KL; Canziani, ME; Cuppari, L; Nakao, LS; Ramos, CI; Ribeiro Dolenga, CJ | 1 |
| Huang, YC; Huang, YF; Lin, CN; Ning, HC; Peng, SY; Wu, IW | 1 |
| Bao, M; Cao, X; Ding, X; Jiao, X; Xie, T; Yu, X; Zhang, P; Zou, J | 1 |
| Adesso, S; Autore, G; Marzocco, S; Nishijima, F; Piaz, FD; Pinto, A; Popolo, A; Raffaele Di Iorio, B; Rapa, SF; Ruocco, M | 1 |
| Bennis, Y; Bodeau, S; Choukroun, G; Cluet, Y; Combe, C; Dussol, B; El Esper, N; Fouque, D; Liabeuf, S; Titeca-Beauport, D; Ureña, P | 1 |
| Bi, X; Han, W; He, T; Huang, Y; Liu, C; Liu, Y; Xiao, T; Xiong, J; Xu, X; Yang, K; Yu, Y; Zhang, B; Zhang, J; Zhao, J; Zheng, C | 1 |
| Deltombe, O; Eloot, S; Glorieux, G; Marzouki, S; Masereeuw, R; Schneditz, D | 1 |
| Autore, G; Dal Piaz, F; Di Iorio, B; Di Micco, L; Marzocco, S; Sirico, ML; Tartaglia, D; Torraca, S | 1 |
| Arnaud, L; Brunet, P; Burtey, S; Calaf, R; Cerini, C; Dignat-George, F; Dou, L; Duval-Sabatier, A; Gondouin, B; Jourde-Chiche, N; Lacroix, R; Pletinck, A; Poitevin, S; Sallée, M; Vanholder, R | 1 |
| Hung, KC; Lin, SL; Wang, CY; Wen, MS | 1 |
| Armstrong, EJ; Granick, JL; Simon, SI | 1 |
| Higashijima, Y; Nangaku, M; Tanaka, T; Yamaguchi, J | 1 |
| Bammens, B; Claes, K; Evenepoel, P; Kuypers, D; Meijers, B; Naesens, M; Poesen, R; Sprangers, B; Vanrenterghem, Y; Verbeke, K; Viaene, L | 1 |
| Fujii, S; Goto, Y; Inada, C; Itaba, S; Kurumatani, H; Matsuda, F; Matsuura, H; Miyamoto, M; Mochizuki, H; Okazaki, S; Sato, N; Tamura, M; Yamada, M; Yamaguchi, S | 1 |
| Brunet, P; Cohen, G; De Vriese, A; Eloot, S; Glorieux, G; Gondouin, B; Pletinck, A; Rops, A; Schepers, E; Van Biesen, W; Van de Voorde, J; van der Vlag, J; Van Landschoot, M; Vanholder, R | 1 |
| Chen, HH; Chuang, CK; Lin, CJ; Liu, HL; Pan, CF; Sun, FJ; Wang, TJ; Wu, CJ | 1 |
| Adesso, S; Autore, G; Bianco, G; Marzocco, S; Pinto, A; Popolo, A; Sorrentino, R | 1 |
| Croze, M; Fouque, D; Mafra, D; Soulage, CO; Stockler-Pinto, MB | 1 |
| Ito, S; Yoshida, M | 1 |
| Exner, M; Gmeiner, BM; Hermann, M; Jirovetz, L; Kapiotis, S; Laggner, H; Praschberger, M; Wanner, J | 1 |
| Enomoto, A; Nishijima, F; Niwa, T; Saito, S; Shimizu, H; Yisireyili, M | 1 |
| Adelibieke, Y; Lee, CT; Ng, HY; Nishijima, F; Niwa, T; Saito, S; Yisireyili, M | 1 |
| Campbell, KL; Coombes, JS; Hawley, CM; Isbel, N; Johnson, DW; McWhinney, BC; Rossi, M; Stanton, T; Ungerer, JP; Vesey, DA; Weston, KS | 1 |
| Glorieux, G; Nagler, EV; Pletinck, A; Schepers, E; Vanholder, R | 1 |
| Campbell, K; Dimeski, G; Hawley, C; Isbel, N; Johnson, D; McWhinney, B; Pascoe, E; Rossi, M; Stanton, T; Ungerer, J | 1 |
| Alexander, D; Boerwinkle, E; Coresh, J; Nettleton, JA; Yu, B; Zheng, Y | 1 |
| Choukroun, G; Desjardins, L; Kamel, S; Lemke, HD; Liabeuf, S; Louvet, L; Massy, ZA; Oliveira, RB; Vanholder, R | 1 |
| Abudureyimu, S; Adelibieke, Y; Murohara, T; Ng, HY; Nishijima, F; Niwa, T; Saito, S; Takeshita, K; Yisireyili, M | 1 |
| Hosomi, A; Komori, H; Lu, Y; Nakanishi, T; Tamai, I | 1 |
| Ameri, P; Balbi, M; Barisione, C; Brunelli, C; Canepa, M; Ghigliotti, G | 1 |
| Krum, H; Lekawanvijit, S | 1 |
| Brinkkoetter, PT; Hagmann, H | 1 |
| Gu, J; Guan, X; He, T; Nie, L; Wang, C; Wang, J; Wang, S; Xia, X; Xiao, T; Xu, X; Yang, K; Zhao, J; Zhao, X | 1 |
| Fu, H; Liu, Y | 1 |
| Chen, HH; Chuang, CK; Lin, CJ; Lin, J; Liu, HL; Pan, CF; Sun, FJ; Wang, TJ; Wu, CJ | 1 |
| Fukushima, A; Furihata, T; Ishimori, N; Kadoguchi, T; Kinugawa, S; Matsushima, S; Nishikawa, M; Saito, A; Takada, S; Tsutsui, H; Yokota, T | 1 |
| Chen, PY; Chung, FM; Huang, LL; Hung, WC; Lai, WT; Lee, KT; Lee, YJ; Lu, LF; Luo, CH; Tang, WH; Wang, CP; Yu, TH | 1 |
| Shen, Y; Wang, L; Wang, P; Yin, A; Yuan, Z; Zhou, J | 1 |
| Campbell, KL; Carrero, JJ; French, C; Johnson, DW; Pascoe, E; Rossi, M; Xu, H | 1 |
| Asai, H; Hirai, K; Hirata, J; Inada, M; Matsumoto, C; Miyaura, C; Watanabe-Akanuma, M; Yamato, H | 1 |
| Beetham, KS; Campbell, KL; Coombes, JS; Haluska, BA; Hawley, CM; Isbel, NM; Krishnasamy, R; Leano, R; Pascoe, EM; Petchey, W; Rossi, M; Stanton, T; Tan, KS | 1 |
| Kumagai, H; Matsubara, H; Nishida, Y; Onimaru, H; Oshima, N; Takechi, H; Uchida, T; Watanabe, A | 1 |
| Ellis, RJ; Francis, R; Gobe, GC; Johnson, DW; Morais, C; Small, DM; Vesey, DA; Vitetta, L | 1 |
| Chen, HH; Lin, CJ; Liou, TC; Liu, HL; Pan, CF; Sun, FJ; Wu, CJ; Wu, PC | 1 |
| Goto, S; Kaneko, Y; Kawamura, K; Kazama, JJ; Matsuo, K; Narita, I; Takahashi, Y; Wakamatsu, T; Yamamoto, S | 1 |
| Kawamura, K; Kazama, JJ; Maruyama, T; Matsuo, K; Matsuto, T; Narita, I; Omori, K; Takahashi, Y; Watanabe, H; Yamamoto, S | 1 |
| Chillon, JM; Drueke, TB; Gross, P; Massy, ZA; Poirot, S; Rémond, MC; Six, I | 1 |
| Deltombe, O; Dhondt, A; Eloot, S; Glorieux, G; Massy, Z; Van Biesen, W | 1 |
| Liu, X; Lu, F; Lu, Z; Zeng, Y; Zheng, Y; Zou, C | 1 |
| Gao, Y; Gao, Z; Wang, L | 1 |
| Fouque, D; Mafra, D; Saldanha, JF; Soulage, CO; Stockler-Pinto, MB; Yi, D | 1 |
| Chen, CS; Huang, MF; Hwang, SJ; Kuo, KC; Kuo, MC; Liang, SS; Liu, TL; Tsai, JC; Wu, PH; Yang, YH; Yeh, YC | 1 |
| Burtey, S; Dou, L | 1 |
| Chen, C; Dai, Z; Hua, Z; Li, D; Liu, X; Lu, F; Lu, Z; Qu, P; Qu, Y; Zeng, YQ; Zou, C | 1 |
| Davenport, A; Kandouz, S; Mohamed, AS; Sandeman, S; Zheng, Y | 1 |
| Chen, W; Chen, X; Gao, S; Shu, C; Xia, T; Zhang, F | 1 |
| Al Khodor, S; Shatat, IF | 1 |
| Chen, SC; Chung, FM; Houng, JY; Hsu, CC; Hung, WC; Lee, YJ; Lu, YC; Tang, WH; Tsai, IT; Wang, CP; Yu, TH | 1 |
| Hoffmann, M; Liu, H; Narayanan, R; Surapaneni, S | 1 |
| Ichimura, Y; Ideuchi, H; Oda, M; Saitoh, H; Takamatsu, H; Takeda, K | 1 |
| Cao, X; Ding, X; Liu, Z; Lv, W; Shen, B; Tan, X; Teng, J; Zhang, X; Zou, J | 1 |
| Hattori, M; Itoh, Y; Kikuchi, M; Suda, W; Ueno, M | 1 |
| Chen, J; Ding, X; Ji, J; Liu, T; Teng, J; Zhang, H; Zhang, X | 1 |
| Liabeuf, S; Massy, ZA; Villain, C | 1 |
| Abe, T; Ito, S; Kisu, K; Koizumi, K; Kudo, T; Kurasawa, N; Mishima, E; Miura, D; Mokudai, T; Mori, T; Morikawa-Ichinose, T; Naganuma, E; Niwa, T; Niwano, Y; Oba-Yabana, I; Oe, Y; Saigusa, D; Saito, R; Sato, E; Sato, H; Sugawara, S; Suzuki, A; Suzuki, C; Takahashi, N | 1 |
| Davies, N; Hilder, EF; Jose, MD; Karu, N; McKercher, C; Nichols, DS; Shellie, RA | 1 |
| Devlin, AS; Dodd, D; Fischbach, MA; Marcobal, A; Meyer, T; Nayfach, S; Plummer, N; Pollard, KS; Sonnenburg, JL | 1 |
| Inagi, R; Tanaka, T; Yamaguchi, J | 1 |
| Chen, HH; Lin, CJ; Liu, HL; Pan, CF; Sun, FJ; Wang, TJ; Wu, CJ; Wu, PC; Yeh, HI | 1 |
| Hung, SC; Kuo, KL; Tarng, DC; Wu, CC | 2 |
| Kamiński, TW; Karbowska, M; Myśliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Chen, F; Chen, M; Chen, S; Du, C; He, T; Hu, M; Li, F; Shen, M; Su, Y; Wang, J; Wang, S; Wang, X; Xu, Y; Yang, K; Zhao, J | 1 |
| Chu, S; Guo, H; Li, Z; Mao, X; Peng, W; Wang, H; Wang, L; Wang, Y; Zhang, X; Zhang, Y | 1 |
| Masai, N; Morita, T; Tatebe, J; Yoshino, G | 1 |
| Drüeke, TB; Liabeuf, S; Massy, ZA | 1 |
| Jang, YH; Kang, DH; Kim, SH; Ryu, ES; Yu, MA | 1 |
| Kelly, DJ; Kompa, AR; Krum, H; Langham, RG; Lekawanvijit, S; Manabe, M; Nishijima, F; Wang, BH | 1 |
| Guan, X; Huang, Y; Nie, L; Xiao, T; Yang, K; Zhang, J; Zhao, J | 1 |
| Hirashiki, A; Kondo, T; Murohara, T; Niwa, T; Okamoto, R; Okumura, T; Shimazu, S; Shinoda, N; Takeshita, K; Yamada, T | 1 |
| Fujii, H; Goto, S; Kitamura, K; Kono, K; Nakai, K; Nishi, S | 1 |
| Bai, X; Cheng, XL; Lin, RC; Mei, Q; Tan, XJ; Wei, F; Zhao, YY | 1 |
| Hayashi, M; Inoue, Y; Ishii, H; Kumagai, S; Matsubara, T; Matsumoto, M; Murohara, T; Niwa, T; Okumura, S; Sato, B; Suzuki, S; Takeshita, K; Tanaka, M; Yoshikawa, D | 1 |
| Boelaert, J; Eloot, S; Glorieux, G; Lynen, F; Sandra, P; Van Landschoot, M; Vanholder, R; Waterloos, MA | 1 |
| Higuchi, Y; Ishii, H; Ito, S; Nishijima, F; Osaka, M; Yagi, Y; Yamato, H; Yoshida, M | 1 |
45 review(s) available for indican and Chronic Kidney Diseases
| Article | Year |
|---|---|
Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Gene Expression Regulation; Humans; Indican; NFATC Transcription Factors; Osteoblasts; Osteoclasts; Osteogenesis; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Signal Transduction | 2021 |
Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?
Topics: Cerebrovascular Disorders; Humans; Indican; Renal Insufficiency, Chronic; Uremia; Uremic Toxins | 2021 |
Effects of Microbiota-Driven Therapy on Circulating Indoxyl Sulfate and P-Cresyl Sulfate in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Topics: Humans; Indican; Microbiota; Prebiotics; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Sulfates | 2022 |
Emotional and cognitive changes in chronic kidney disease.
Topics: Cerebrovascular Disorders; Cognition; Female; Humans; Indican; Male; Renal Insufficiency, Chronic; Uremia | 2022 |
What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis.
Topics: Female; Humans; Indican; Liver; Male; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Uremia; Uremic Toxins | 2022 |
Research progress on the relationship between IS and kidney disease and its complications.
Topics: Humans; Indican; Phenols; Renal Insufficiency, Chronic; Sulfates; Uremic Toxins | 2022 |
Protein-bound uremic toxins (PBUTs) in chronic kidney disease (CKD) patients: Production pathway, challenges and recent advances in renal PBUTs clearance.
Topics: Humans; Indican; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin; Sulfates; Uremia; Uremic Toxins | 2021 |
The impact of dietary nutrient intake on gut microbiota in the progression and complications of chronic kidney disease.
Topics: Amino Acids; Diet; Dietary Fiber; Eating; Ecosystem; Fatty Acids, Volatile; Gastrointestinal Microbiome; Humans; Indican; Nutrients; Renal Insufficiency, Chronic; Sulfates | 2022 |
Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation.
Topics: Fatty Acids, Volatile; Humans; Indican; Inflammation; Prebiotics; Pregnane X Receptor; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Tryptophan | 2022 |
Letter to the Editor on the "Effects of Microbiota-driven Therapy on Circulating Indoxyl Sulfate and p-Cresyl Sulfate in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials".
Topics: Humans; Indican; Microbiota; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Sulfates | 2022 |
Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal Failure.
Topics: Colonic Neoplasms; Humans; Indican; Inflammation; Kidney Failure, Chronic; Renal Insufficiency, Chronic; Sulfates; Uremic Toxins | 2023 |
Indoxyl sulfate in atherosclerosis.
Topics: Albumins; Atherosclerosis; Cardiovascular Diseases; Chronic Disease; Humans; Indican; Renal Insufficiency, Chronic; Uremia | 2023 |
Synbiotics, prebiotics and probiotics for people with chronic kidney disease.
Topics: Adult; Child; Dysbiosis; Humans; Indican; Prebiotics; Probiotics; Renal Insufficiency, Chronic; Synbiotics; Uremic Toxins | 2023 |
Sarcopenia in Chronic Kidney Disease: Factors, Mechanisms, and Therapeutic Interventions.
Topics: Cytokines; Humans; Indican; Muscle Proteins; Muscle, Skeletal; Myostatin; Oxidative Stress; Proteolysis; Reactive Oxygen Species; Renal Insufficiency, Chronic; Sarcopenia | 2019 |
Uremic Toxins and Atrial Fibrillation: Mechanisms and Therapeutic Implications.
Topics: Animals; Atrial Fibrillation; Carbon; Humans; Indican; Oxides; Renal Insufficiency, Chronic; Toxins, Biological; Uremia | 2019 |
Molecular and Cellular Mechanisms that Induce Arterial Calcification by Indoxyl Sulfate and P-Cresyl Sulfate.
Topics: Aged; Animals; Cresols; Endothelial Cells; Humans; Indican; Male; Rats; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Vascular Diseases | 2020 |
Indoxyl Sulfate, a Uremic Endotheliotoxin.
Topics: Animals; Cardiovascular Diseases; Endothelium, Vascular; Humans; Indican; Prognosis; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors; Signal Transduction; Toxins, Biological; Uremia | 2020 |
Chronic Kidney Disease-Associated Immune Dysfunctions: Impact of Protein-Bound Uremic Retention Solutes on Immune Cells.
Topics: Animals; Cresols; Humans; Immune System; Immunity, Cellular; Immunity, Humoral; Immunity, Innate; Indican; Kidney; Protein Binding; Renal Insufficiency, Chronic; Sulfuric Acid Esters; T-Lymphocytes; Uremia | 2020 |
Uremic Toxins and Vascular Dysfunction.
Topics: Animals; Blood Vessels; Cresols; Fibroblast Growth Factor-23; Humans; Indican; Inflammation Mediators; Oxidative Stress; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremia; Vascular Diseases | 2020 |
Indoxyl Sulfate, a Tubular Toxin, Contributes to the Development of Chronic Kidney Disease.
Topics: Animals; Cell Death; Fibrosis; Humans; Indican; Kidney; Oxidative Stress; Renal Insufficiency, Chronic; Toxins, Biological; Transforming Growth Factor beta1 | 2020 |
Uremic Vascular Calcification: The Pathogenic Roles and Gastrointestinal Decontamination of Uremic Toxins.
Topics: Clinical Trials as Topic; Decontamination; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Indican; Isoquinolines; Renal Insufficiency, Chronic; Sulfonamides; Toxins, Biological; Uremia; Vascular Calcification | 2020 |
Protein-bound uremic toxin lowering strategies in chronic kidney disease: a systematic review and meta-analysis.
Topics: Humans; Indican; Renal Dialysis; Renal Insufficiency, Chronic; Synbiotics; Uremic Toxins | 2021 |
Protein-Bound Uremic Toxins and Immunity.
Topics: Adaptive Immunity; Cardiovascular Diseases; Cresols; Gastrointestinal Microbiome; Humans; Immunity, Innate; Indican; Inflammation; Renal Insufficiency, Chronic; Sulfuric Acid Esters; T-Lymphocytes; Toxins, Biological; Uremia | 2021 |
Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins.
Topics: Animals; Cardiovascular Diseases; Glucuronates; Humans; Indican; Indoleacetic Acids; Indoles; Models, Biological; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Uremia | 2017 |
Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease.
Topics: Animals; Cardiovascular Diseases; Coronary Artery Disease; Disease Progression; Humans; Indican; NADPH Oxidases; Oxidation-Reduction; Oxidative Stress; Renal Insufficiency, Chronic | 2017 |
Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease.
Topics: Animals; Humans; Indican; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic | 2017 |
Contributory Role of Gut Microbiota and Their Metabolites Toward Cardiovascular Complications in Chronic Kidney Disease.
Topics: Animals; Cardiovascular Diseases; Cresols; Diet Therapy; Dietary Supplements; Dysbiosis; Enzyme Inhibitors; Fatty Acids, Volatile; Gastrointestinal Microbiome; Humans; Indican; Inflammation; Methylamines; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological | 2018 |
Updates on the Mechanisms and the Care of Cardiovascular Calcification in Chronic Kidney Disease.
Topics: Animals; Anti-Inflammatory Agents; Calcimimetic Agents; Calcium; Cardiovascular Diseases; Chelating Agents; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glucuronidase; Glycation End Products, Advanced; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indican; Inflammation; Klotho Proteins; Magnesium; Mesenchymal Stem Cells; Phosphates; Renal Insufficiency, Chronic; Tunica Intima; Tunica Media; Vascular Calcification; Vitamin K 2; Zinc Finger Protein GLI1 | 2018 |
Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β
Topics: Amyloidosis; Animals; Atherosclerosis; Awards and Prizes; beta 2-Microglobulin; Humans; Indican; Lipoproteins, HDL; Macrophages; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors; Uremia | 2019 |
Impacts of Indoxyl Sulfate and p-Cresol Sulfate on Chronic Kidney Disease and Mitigating Effects of AST-120.
Topics: Adsorption; Animals; Carbon; Cresols; Humans; Indican; Oxides; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2018 |
Association between fibre intake and indoxyl sulphate/P-cresyl sulphate in patients with chronic kidney disease: Meta-analysis and systematic review of experimental studies.
Topics: Adult; Aged; Cresols; Dietary Fiber; Female; Humans; Indican; Male; Middle Aged; Randomized Controlled Trials as Topic; Renal Dialysis; Renal Insufficiency, Chronic; Salicylates | 2019 |
Diet, gut microbiome and indoxyl sulphate in chronic kidney disease patients.
Topics: Animals; Bacteria; Diet, Healthy; Dietary Fiber; Dysbiosis; Fruit; Gastrointestinal Microbiome; Gastrointestinal Tract; Host-Pathogen Interactions; Humans; Indican; Prognosis; Recommended Dietary Allowances; Renal Insufficiency, Chronic; Risk Factors; Symbiosis; Vegetables | 2018 |
Indoxyl sulfate and p-cresyl sulfate in chronic kidney disease. Could these toxins modulate the antioxidant Nrf2-Keap1 pathway?
Topics: Antioxidants; Cresols; Gene Expression Regulation; Humans; Indican; Inflammation; Intestines; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Microbiota; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Renal Insufficiency, Chronic; Signal Transduction; Sulfuric Acid Esters | 2014 |
Protein-bound uremic toxins: new culprits of cardiovascular events in chronic kidney disease patients.
Topics: Animals; Atherosclerosis; Carbon; Cresols; Humans; Indican; Oxides; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2014 |
The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review.
Topics: Animals; Cresols; Disease Models, Animal; Humans; Indican; Kidney; Models, Biological; Protein Binding; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2014 |
Indoxyl sulfate: a candidate target for the prevention and treatment of cardiovascular disease in chronic kidney disease.
Topics: Animals; Anti-Inflammatory Agents; Basic Helix-Loop-Helix Transcription Factors; Cardiovascular Diseases; Drug Design; Humans; Indican; Inflammation Mediators; Molecular Targeted Therapy; Receptors, Aryl Hydrocarbon; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors; Signal Transduction | 2015 |
Cardiorenal syndrome: role of protein-bound uremic toxins.
Topics: Cardio-Renal Syndrome; Cresols; Humans; Indican; Proteinuria; Renal Insufficiency, Chronic; Uremia | 2015 |
Indoxyl sulphate and kidney disease: Causes, consequences and interventions.
Topics: Animals; Bacteria; Diet, Protein-Restricted; Dietary Fiber; Dysbiosis; Gastrointestinal Microbiome; Glomerular Filtration Rate; Humans; Indican; Kidney; Probiotics; Renal Insufficiency, Chronic; Up-Regulation; Urological Agents | 2016 |
Gut microbiome and kidney disease: a bidirectional relationship.
Topics: Carbon; Child; Dietary Supplements; Disease Progression; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Humans; Hypertension; Indican; Indoles; Oxides; Renal Dialysis; Renal Insufficiency, Chronic | 2017 |
Indoxyl sulfate, a valuable biomarker in chronic kidney disease and dialysis.
Topics: Biomarkers; Humans; Indican; Renal Dialysis; Renal Insufficiency, Chronic | 2017 |
Protein-bound toxins: has the Cinderella of uraemic toxins turned into a princess?
Topics: Animals; Cardiovascular Diseases; Cresols; Humans; Indican; Indoleacetic Acids; Proteins; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremia | 2016 |
Effect of AST-120 in Chronic Kidney Disease Treatment: Still a Controversy?
Topics: Adsorption; Animals; Carbon; Clinical Trials as Topic; Humans; Indican; Japan; Oxides; Renal Insufficiency, Chronic; Toxins, Biological | 2017 |
Impact of Indoxyl Sulfate on Progenitor Cell-Related Neovascularization of Peripheral Arterial Disease and Post-Angioplasty Thrombosis of Dialysis Vascular Access.
Topics: Angioplasty; Animals; Blood Coagulation; Blood Vessel Prosthesis Implantation; Endothelial Progenitor Cells; Graft Occlusion, Vascular; Humans; Indican; Neovascularization, Pathologic; Peripheral Arterial Disease; Prognosis; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors; Thrombosis | 2017 |
Indoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease.
Topics: Biomarkers; Cardiovascular Diseases; Humans; Indican; Renal Insufficiency, Chronic; Risk Factors | 2017 |
Protein-bound uremic toxins: new insight from clinical studies.
Topics: Cardiovascular Diseases; Cresols; Disease Progression; Heart; Humans; Indican; Kidney; Protein Binding; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2011 |
14 trial(s) available for indican and Chronic Kidney Diseases
| Article | Year |
|---|---|
Protein-Bound Uremic Toxins Lowering Effect of Sevelamer in Pre-Dialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized Controlled Trial.
Topics: Calcium Carbonate; Chelating Agents; Cresols; Female; Humans; Hyperphosphatemia; Indican; Male; Middle Aged; Renal Insufficiency, Chronic; Sevelamer; Sulfuric Acid Esters; Uremic Toxins | 2021 |
Diet Quality and Protein-Bound Uraemic Toxins: Investigation of Novel Risk Factors and the Role of Microbiome in Chronic Kidney Disease.
Topics: Animals; Cresols; Cross-Sectional Studies; Diet; Dietary Fiber; Humans; Indican; Microbiota; Renal Insufficiency, Chronic; Risk Factors; Sulfates; Uremic Toxins | 2022 |
The Impact of Synbiotic Treatment on the Levels of Gut-Derived Uremic Toxins, Inflammation, and Gut Microbiome of Chronic Kidney Disease Patients-A Randomized Trial.
Topics: Adolescent; Adult; C-Reactive Protein; Gastrointestinal Microbiome; Humans; Indican; Inflammation; Renal Insufficiency, Chronic; Synbiotics; Uremic Toxins | 2023 |
Enzobiotics-A Novel Therapy for the Elimination of Uremic Toxins in Patients with CKD (EETOX Study): A Multicenter Double-Blind Randomized Controlled Trial.
Topics: Cresols; Double-Blind Method; Humans; Indican; Middle Aged; Peptide Hydrolases; Quality of Life; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremic Toxins | 2022 |
Low-protein diet supplemented with inulin lowers protein-bound toxin levels in patients with stage 3b-5 chronic kidney disease: a randomized controlled study.
Topics: Diet, Protein-Restricted; Dietary Proteins; Dietary Supplements; Humans; Indican; Inflammation; Inulin; Kidney Failure, Chronic; Renal Insufficiency, Chronic | 2023 |
Comparison of Different Types of Oral Adsorbent Therapy in Patients with Chronic Kidney Disease: A Multicenter, Randomized, Phase IV Clinical Trial.
Topics: Adsorption; Carbon; Creatinine; Cross-Over Studies; Cystatin C; Disease Progression; Female; Glomerular Filtration Rate; Humans; Indican; Male; Middle Aged; Oxides; Renal Insufficiency, Chronic; Treatment Outcome | 2021 |
An Innovative Synbiotic Formulation Decreases Free Serum Indoxyl Sulfate, Small Intestine Permeability and Ameliorates Gastrointestinal Symptoms in a Randomized Pilot Trial in Stage IIIb-IV CKD Patients.
Topics: Case-Control Studies; Dysbiosis; Female; Gastrointestinal Diseases; Gastrointestinal Microbiome; Humans; Indican; Intestine, Small; Male; Middle Aged; Permeability; Pilot Projects; Renal Insufficiency, Chronic; Single-Blind Method; Synbiotics | 2021 |
Impact of Indoxyl Sulfate on Coronary Plaques in Patients on Hemodialysis.
Topics: Aged; Biomarkers; Computed Tomography Angiography; Coronary Artery Disease; Coronary Vessels; Female; Humans; Indican; Male; Middle Aged; Multidetector Computed Tomography; Plaque, Atherosclerotic; Prospective Studies; Renal Dialysis; Renal Insufficiency, Chronic; Risk Assessment; Vascular Calcification | 2018 |
Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial.
Topics: Adult; Anthropometry; Biomarkers; C-Reactive Protein; Cresols; Female; Humans; Indican; Interleukin-6; Male; Middle Aged; Oxidative Stress; Pilot Projects; Prebiotics; Renal Dialysis; Renal Insufficiency, Chronic; Starch; Sulfuric Acid Esters; Thiobarbituric Acid Reactive Substances; Urine; Zea mays | 2018 |
Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial.
Topics: Aged; Bifidobacterium longum; Biomarkers; Brazil; Cresols; Female; Gastrointestinal Microbiome; Humans; Hydrogen-Ion Concentration; Indican; Indoleacetic Acids; Male; Meals; Middle Aged; Probiotics; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Synbiotics; Urea; Uremia | 2019 |
The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial.
Topics: Adsorption; Aged; Chelating Agents; Cresols; Double-Blind Method; Female; Gastrointestinal Tract; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Renal Insufficiency, Chronic; Sevelamer; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2019 |
Very low protein diet reduces indoxyl sulfate levels in chronic kidney disease.
Topics: Aged; Amino Acids; Case-Control Studies; Creatinine; Cross-Over Studies; Diet, Protein-Restricted; Disease Progression; Female; Fibroblast Growth Factor-23; Humans; Indican; Keto Acids; Male; Middle Aged; Pilot Projects; Prospective Studies; Renal Dialysis; Renal Insufficiency, Chronic; Treatment Outcome | 2013 |
Renal clearance and intestinal generation of p-cresyl sulfate and indoxyl sulfate in CKD.
Topics: Age Factors; Aged; Biomarkers; Cresols; Female; Glomerular Filtration Rate; Humans; Indican; Intestinal Mucosa; Male; Middle Aged; Renal Insufficiency, Chronic; Sex Factors; Sulfuric Acid Esters | 2013 |
Dietary protein-fiber ratio associates with circulating levels of indoxyl sulfate and p-cresyl sulfate in chronic kidney disease patients.
Topics: Aged; Biomarkers; Body Mass Index; Cresols; Cross-Sectional Studies; Dietary Fiber; Dietary Proteins; Energy Intake; Female; Humans; Indican; Linear Models; Male; Middle Aged; Multivariate Analysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters | 2015 |
195 other study(ies) available for indican and Chronic Kidney Diseases
| Article | Year |
|---|---|
Is there an association between the plasma levels of uremic toxins from gut microbiota and anemia in patients on hemodialysis?
Topics: Anemia; Cross-Sectional Studies; Female; Gastrointestinal Microbiome; Humans; Indican; Male; Renal Dialysis; Renal Insufficiency, Chronic; Uremia; Uremic Toxins | 2022 |
Effects of prebiotic oligofructose-enriched inulin on gut-derived uremic toxins and disease progression in rats with adenine-induced chronic kidney disease.
Topics: Adenine; Animals; Blood Urea Nitrogen; Cresols; Disease Models, Animal; Dysbiosis; Humans; Indican; Inflammation; Interleukin-6; Inulin; Oligosaccharides; Prebiotics; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Urea | 2021 |
Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease.
Topics: Adult; Aged; Biomarkers; Cohort Studies; Female; Glomerular Filtration Rate; Glycocalyx; Humans; Indican; Linear Models; Male; MicroRNAs; Middle Aged; Multivariate Analysis; Renal Insufficiency, Chronic; Syndecan-1; Toxins, Biological; Uremia | 2021 |
Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins.
Topics: Aging; Cell Movement; Cellular Senescence; Cresols; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Indican; Renal Insufficiency, Chronic | 2021 |
Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD.
Topics: Animals; Aorta; Carotid Artery Injuries; Carotid Artery Thrombosis; Culture Media; Enzyme Induction; Feedback, Physiological; Female; HEK293 Cells; Humans; Indican; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Myocytes, Smooth Muscle; Postoperative Complications; Renal Insufficiency, Chronic; Thromboplastin; Thrombosis; Tryptophan; Uremia; Vascular Surgical Procedures | 2021 |
The Accumulation of Gut Microbiome-derived Indoxyl Sulfate and P-Cresyl Sulfate in Patients With End-stage Renal Disease.
Topics: Cresols; Dialysis Solutions; Gastrointestinal Microbiome; Humans; Indican; Indoles; Kidney Failure, Chronic; Renal Insufficiency, Chronic; RNA, Ribosomal, 16S; Sulfates; Sulfuric Acid Esters; Tryptophan | 2022 |
Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease.
Topics: Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Disease Models, Animal; Hindlimb; Humans; Indican; Ischemia; Kynurenine; Mice; Middle Aged; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Tryptophan; Wnt Signaling Pathway | 2022 |
Early elimination of uremic toxin ameliorates AKI-to-CKD transition.
Topics: Acute Kidney Injury; Animals; Butylamines; Carbon; Drug Evaluation, Preclinical; Indican; Mice, Inbred C57BL; Nephrosclerosis; Oxides; Renal Insufficiency, Chronic; Reperfusion Injury; Senescence-Associated Secretory Phenotype; Unfolded Protein Response | 2021 |
Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients.
Topics: Caspase 1; Cytokines; Gene Expression Regulation; Humans; Indican; Inflammasomes; Interleukin-1beta; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Renal Dialysis; Renal Insufficiency, Chronic; T-Lymphocytes, Helper-Inducer; THP-1 Cells | 2021 |
Indoxyl Sulfate Elevated Lnc-SLC15A1-1 Upregulating CXCL10/CXCL8 Expression in High-Glucose Endothelial Cells by Sponging MicroRNAs.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Chemokine CXCL10; Diabetes Mellitus, Type 2; Endothelial Cells; Female; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Indican; Male; MicroRNAs; Middle Aged; Peptide Transporter 1; Renal Insufficiency, Chronic; Toxins, Biological; Up-Regulation | 2021 |
Indoxyl sulfate in uremia: an old idea with updated concepts.
Topics: Animals; Humans; Indican; Mice; Renal Dialysis; Renal Insufficiency, Chronic; Uremia; Zebrafish | 2022 |
Indoxyl Sulfate Activates NLRP3 Inflammasome to Induce Cardiac Contractile Dysfunction Accompanied by Myocardial Fibrosis and Hypertrophy.
Topics: Animals; Cardiomegaly; Cardiomyopathies; Female; Fibrosis; Heart Diseases; Humans; Indican; Inflammasomes; Male; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Inbred Dahl; Renal Insufficiency, Chronic | 2022 |
Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-κB signaling pathways.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Electrocardiography; Gene Expression Regulation; Indican; Male; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; NF-kappa B; Patch-Clamp Techniques; Rats; Rats, Wistar; Renal Insufficiency, Chronic; RNA; Shaker Superfamily of Potassium Channels; Signal Transduction; Tachycardia, Ventricular | 2022 |
Lactobacillus rhamnosus L34 attenuates chronic kidney disease progression in a 5/6 nephrectomy mouse model through the excretion of anti-inflammatory molecules.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Culture Media, Conditioned; Disease Models, Animal; Fibrosis; Humans; Indican; Inflammation; Lacticaseibacillus rhamnosus; Mice; Nephrectomy; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha | 2022 |
Neutrophil:lymphocyte ratio correlates with the uremic toxin indoxyl sulfate and predicts the risk of death in patients on hemodialysis.
Topics: Biomarkers; Cardiovascular Diseases; Humans; Indican; Lymphocytes; Neutrophils; Prospective Studies; Renal Dialysis; Renal Insufficiency, Chronic; Toxins, Biological; Uremic Toxins | 2022 |
Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings.
Topics: Animals; Aorta, Thoracic; Azo Compounds; Cytochrome P-450 CYP1A1; Endothelium, Vascular; Gene Expression; Indican; Male; Oxidative Stress; Pyrazoles; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Vasodilation | 2022 |
Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.
Topics: Animals; C-Reactive Protein; Carbazoles; Cells, Cultured; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Indican; Indoleacetic Acids; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Uremia | 2022 |
Uremic toxins activate CREB/ATF1 in endothelial cells related to chronic kidney disease.
Topics: Cyclooxygenase 2; Endothelial Cells; Female; Humans; Indican; Male; Renal Insufficiency, Chronic; Uremic Toxins; Vascular Diseases | 2022 |
Vascular Endothelial Dysfunction in the Thoracic Aorta of Rats with Ischemic Acute Kidney Injury: Contribution of Indoxyl Sulfate.
Topics: Acute Kidney Injury; Animals; Aorta, Thoracic; Carbon; Disease Models, Animal; Disease Progression; Endothelial Cells; Endothelium, Vascular; Indican; Ischemia; Male; Nitric Oxide; Oxides; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recovery of Function; Renal Insufficiency, Chronic; Reperfusion Injury; Signal Transduction | 2022 |
Mechanisms of myostatin and activin A accumulation in chronic kidney disease.
Topics: Activins; Animals; Humans; Indican; Mammals; Mice; Muscle, Skeletal; Myostatin; Renal Insufficiency, Chronic | 2022 |
Uremic toxin indoxyl sulfate induces dysfunction of vascular smooth muscle cells via integrin-β1/ERK signaling pathway.
Topics: Cardiovascular Diseases; Endothelial Cells; Humans; Indican; Integrin beta1; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Renal Insufficiency, Chronic; Signal Transduction; Uremic Toxins | 2022 |
Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells.
Topics: Adenosine Triphosphate; Animals; Female; Humans; Indican; Inflammation; Male; Mice; Muscular Atrophy; Myoblasts; Oxidative Stress; Pyruvaldehyde; Renal Insufficiency, Chronic; Sarcopenia | 2022 |
Does Mediterranean Adequacy Index Correlate with Cardiovascular Events in Patients with Advanced Chronic Kidney Disease? An Exploratory Study.
Topics: Adult; Cardiovascular Diseases; Diet, Mediterranean; Female; Humans; Indican; Male; Quality of Life; Renal Insufficiency, Chronic; Sulfates; Toxins, Biological | 2022 |
Indoxyl sulfate impairs
Topics: Anemia; Apoptosis; Erythropoiesis; Humans; Indican; Renal Insufficiency, Chronic; Uremic Toxins | 2022 |
Electrochemical sensing of the secretion of indoxyl sulfate in a rat intestinal loop using a self-assembled monolayer-modified gold bead electrode.
Topics: Animals; Electrodes; Gold; Humans; Indican; Rats; Renal Insufficiency, Chronic; Uric Acid | 2022 |
Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate.
Topics: Antioxidants; Humans; Indican; Oxidative Stress; Renal Insufficiency, Chronic; Superoxide Dismutase | 2022 |
Effects of the uremic toxin indoxyl sulphate on human microvascular endothelial cells.
Topics: Cardiovascular Diseases; Endothelial Cells; Humans; Indican; Proteomics; Renal Insufficiency, Chronic; Uremic Toxins | 2022 |
Chronic Kidney Disease Is Associated With Increased Cardiac Corin Expression But Decreased Proatrial Natriuretic Peptide Conversion Activity.
Topics: Animals; Cell Line; Humans; Indican; Mice; Myocytes, Cardiac; Natriuretic Peptides; Rats; Renal Insufficiency, Chronic; Serine Endopeptidases; Vasodilator Agents | 2022 |
Curcumin enhances p-cresyl sulfate-induced cytotoxic effects on renal tubular cells.
Topics: Cresols; Curcumin; Humans; Indican; Kidney; Renal Insufficiency, Chronic; Sulfates; Sulfuric Acid Esters | 2022 |
Protein/Fiber Index Modulates Uremic Toxin Concentrations in Hemodialysis Patients.
Topics: Cresols; Dietary Fiber; Humans; Indican; Prospective Studies; Proteins; Renal Dialysis; Renal Insufficiency, Chronic; Sulfates; Sulfuric Acid Esters; Toxins, Biological; Uremia; Uremic Toxins | 2022 |
Proton pump inhibitor-induced risk of chronic kidney disease is associated with increase of indoxyl sulfate synthesis via inhibition of CYP2E1 protein degradation.
Topics: Animals; Cytochrome P-450 CYP2E1; Indican; Lansoprazole; Mice; Omeprazole; Pantoprazole; Proteolysis; Proton Pump Inhibitors; Renal Insufficiency, Chronic; Uremic Toxins | 2022 |
Indoxyl Sulfate Might Play a Role in Sarcopenia, While Myostatin Is an Indicator of Muscle Mass in Patients with Chronic Kidney Disease: Analysis from the RECOVERY Study.
Topics: Hand Strength; Humans; Indican; Muscle, Skeletal; Myostatin; Renal Insufficiency, Chronic; Sarcopenia | 2022 |
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Topics: Adenine; Animals; Indican; Molecular Docking Simulation; Rats; Renal Insufficiency, Chronic; Tandem Mass Spectrometry | 2023 |
Rapid and sustainable HPLC method for the determination of uremic toxins in human plasma samples.
Topics: Chromatography, High Pressure Liquid; Cresols; Humans; Indican; Phenol; Renal Insufficiency, Chronic; Toxins, Biological; Uremic Toxins | 2023 |
Scientometric analysis of kidney disease and gut microbiota from 2001 to 2020 based on Web of Science.
Topics: Databases, Factual; France; Gastrointestinal Microbiome; Humans; Indican; Renal Insufficiency, Chronic | 2022 |
Indoxyl sulfate impairs erythropoiesis at BFU-E stage in chronic kidney disease.
Topics: Anemia; Animals; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Humans; Indican; Mice; Renal Insufficiency, Chronic | 2023 |
Astragaloside IV attenuates indoxyl sulfate-induced injury of renal tubular epithelial cells by inhibiting the aryl hydrocarbon receptor pathway.
Topics: Animals; Epithelial Cells; Indican; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic | 2023 |
Assessment of uremic toxins in advanced chronic kidney disease patients on maintenance hemodialysis by LC-ESI-MS/MS.
Topics: Chromatography, Liquid; Creatinine; Humans; Indican; Metabolomics; Renal Dialysis; Renal Insufficiency, Chronic; Sulfates; Tandem Mass Spectrometry; Urea; Uremic Toxins | 2023 |
Indoxyl Sulphate Retention Is Associated with Microvascular Endothelial Dysfunction after Kidney Transplantation.
Topics: Cardiovascular Diseases; Endothelium, Vascular; Humans; Indican; Kidney Transplantation; Nitroprusside; Quality of Life; Renal Insufficiency, Chronic; Vascular Diseases | 2023 |
Gut-Derived Uremic Toxins in CKD: An Improved Approach for the Evaluation of Serum Indoxyl Sulfate in Clinical Practice.
Topics: Chromatography, Liquid; Humans; Indican; Pilot Projects; Renal Dialysis; Renal Insufficiency, Chronic; Tandem Mass Spectrometry; Uremic Toxins | 2023 |
Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment.
Topics: Humans; Indican; Indoles; Metal-Organic Frameworks; Renal Insufficiency, Chronic; Uremia; Uremic Toxins | 2023 |
Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice.
Topics: Animals; Disease Models, Animal; Erythropoietin; Fibrosis; Humans; Indican; Inflammation; Kidney; Mice; Mice, Inbred C57BL; Renal Insufficiency, Chronic; Sulfotransferases; Ureteral Obstruction | 2023 |
Evaluation of effects of indoxyl sulfate and parathyroid hormone on CYP3A activity considering the influence of CYP3A5 gene polymorphisms.
Topics: Cholesterol; Cytochrome P-450 CYP3A; Genotype; Humans; Hydroxycholesterols; Indican; Parathyroid Hormone; Polymorphism, Genetic; Renal Insufficiency, Chronic | 2023 |
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate.
Topics: Animals; Gastrointestinal Microbiome; Humans; Indican; Indoles; Mammals; Mice; Renal Insufficiency, Chronic; Tryptophanase | 2023 |
SLC22A11 Inserts the Uremic Toxins Indoxyl Sulfate and P-Cresol Sulfate into the Plasma Membrane.
Topics: Cell Membrane; Chromatography, Liquid; Cresols; HEK293 Cells; Humans; Indican; Organic Anion Transporters, Sodium-Independent; Renal Insufficiency, Chronic; Tandem Mass Spectrometry; Toxins, Biological; Uremic Toxins | 2023 |
Association between Dental Scores and Saliva Uremic Toxins.
Topics: Chromatography, Liquid; Humans; Indican; Prospective Studies; Renal Insufficiency, Chronic; Saliva; Tandem Mass Spectrometry; Toxins, Biological; Uremia; Uremic Toxins | 2023 |
Indoxyl sulfate associates with cardiovascular phenotype in children with chronic kidney disease.
Topics: Adolescent; Biomarkers; Cardiovascular Diseases; Child; Cresols; Disease Progression; Female; Glomerular Filtration Rate; Humans; Indican; Male; Phenotype; Renal Insufficiency, Chronic; Sulfuric Acid Esters | 2019 |
Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-κB signaling pathway.
Topics: Actins; Cell Line; Chromones; Core Binding Factor Alpha 1 Subunit; Down-Regulation; Humans; Indican; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Renal Insufficiency, Chronic; Signal Transduction; Sulfones; Up-Regulation; Vascular Calcification | 2019 |
Quantitative Translation of Microfluidic Transporter
Topics: Biological Transport; Cell Line; Humans; Indican; Kidney Tubules, Proximal; Kinetics; Membrane Transport Proteins; Microfluidics; Organic Anion Transport Protein 1; Renal Insufficiency, Chronic; Serum Albumin, Human | 2019 |
Association between Serum Indoxyl Sulfate Levels and Endothelial Function in Non-Dialysis Chronic Kidney Disease.
Topics: Aged; Blood Pressure; Creatinine; Female; Glomerular Filtration Rate; Humans; Indican; Male; Middle Aged; Renal Insufficiency, Chronic | 2019 |
Preliminary evaluation of fecal fatty acid concentrations in cats with chronic kidney disease and correlation with indoxyl sulfate and p-cresol sulfate.
Topics: Aging; Animals; Case-Control Studies; Cat Diseases; Cats; Cresols; Fatty Acids, Nonesterified; Feces; Indican; Prospective Studies; Renal Insufficiency, Chronic; Sulfuric Acid Esters | 2020 |
Role of Resveratrol on Indoxyl Sulfate-Induced Endothelial Hyperpermeability via Aryl Hydrocarbon Receptor (AHR)/Src-Dependent Pathway.
Topics: Animals; Antigens, CD; Antioxidants; Aorta; Atherosclerosis; Cadherins; Cattle; Cell Membrane Permeability; Cells, Cultured; Electric Impedance; Endothelial Cells; Indican; Oxidative Stress; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Resveratrol; Signal Transduction; src-Family Kinases | 2019 |
Protein-bound uremic toxins are associated with cognitive function among patients undergoing maintenance hemodialysis.
Topics: Aged; Cognition; Female; Humans; Indican; Language; Male; Memory, Long-Term; Middle Aged; Neuropsychological Tests; Renal Dialysis; Renal Insufficiency, Chronic; Toxins, Biological | 2019 |
Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney disease.
Topics: Animals; Indican; Mice; Mice, Transgenic; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Uremia | 2020 |
The Difference in the Changes of Indoxyl Sulfate after Catheter Ablation among Atrial Fibrillation Patients with and without Kidney Dysfunction.
Topics: Aged; Atrial Fibrillation; Catheter Ablation; Electrocardiography; Female; Glomerular Filtration Rate; Humans; Indican; Kidney; Male; Middle Aged; Prospective Studies; Renal Insufficiency, Chronic | 2020 |
Gut Microbiota as Diagnostic Tools for Mirroring Disease Progression and Circulating Nephrotoxin Levels in Chronic Kidney Disease: Discovery and Validation Study.
Topics: Aged; Biomarkers; Cresols; Female; Gastrointestinal Microbiome; Humans; Indican; Male; Middle Aged; Renal Insufficiency, Chronic; RNA, Ribosomal, 16S; Sulfuric Acid Esters | 2020 |
CharXgen-Activated Bamboo Charcoal Encapsulated in Sodium Alginate Microsphere as the Absorbent of Uremic Toxins to Retard Kidney Function Deterioration.
Topics: Alginates; Animals; Carbon; Cell Line; Charcoal; Cresols; Disease Models, Animal; Humans; Indican; Microscopy, Electron, Scanning; Microspheres; Oxides; Rats; Renal Insufficiency, Chronic; Sasa; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2020 |
Serum Levels and Removal by Haemodialysis and Haemodiafiltration of Tryptophan-Derived Uremic Toxins in ESKD Patients.
Topics: Adult; Aged; Aged, 80 and over; Female; Hemodiafiltration; Humans; Indican; Indoleacetic Acids; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Renal Dialysis; Renal Insufficiency, Chronic; Tryptophan | 2020 |
Isolation and Quantification of Uremic Toxin Precursor-Generating Gut Bacteria in Chronic Kidney Disease Patients.
Topics: Amino Acids, Aromatic; Bacteria; Cresols; Feces; Gastrointestinal Microbiome; Humans; Indican; Indoleacetic Acids; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological | 2020 |
Aryl Hydrocarbon Receptor Activation and Tissue Factor Induction by Fluid Shear Stress and Indoxyl Sulfate in Endothelial Cells.
Topics: Basic Helix-Loop-Helix Transcription Factors; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Gene Expression Regulation; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Indican; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; RNA, Messenger; Stress, Mechanical; Thromboplastin | 2020 |
Oral Charcoal Adsorbents Attenuate Neointima Formation of Arteriovenous Fistulas.
Topics: Administration, Oral; Adsorption; Animals; Arteriovenous Shunt, Surgical; Carbon; Collagen; Disease Models, Animal; Graft Occlusion, Vascular; Indican; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Neointima; Oxides; Renal Insufficiency, Chronic; Toxins, Biological; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Uremia; Vascular Patency | 2020 |
Effect of sucroferric oxyhydroxide on gastrointestinal microbiome and uremic toxins in patients with chronic kidney disease undergoing hemodialysis.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Cresols; Drug Combinations; Dysbiosis; Feces; Ferric Compounds; Gastrointestinal Microbiome; Humans; Indican; Middle Aged; Renal Dialysis; Renal Insufficiency, Chronic; Sucrose; Sulfuric Acid Esters | 2020 |
Factors of microinflammation in non-diabetic chronic kidney disease: a pilot study.
Topics: Bacterial Translocation; Biomarkers; C-Reactive Protein; Female; Gastrointestinal Microbiome; Humans; Indican; Indoleacetic Acids; Inflammation; Kidney Function Tests; Male; Oxidative Stress; Patient Acuity; Pilot Projects; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremia | 2020 |
Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney disease.
Topics: Feces; Gastrointestinal Microbiome; Humans; Indican; Renal Insufficiency, Chronic; Toxins, Biological; Uremia | 2020 |
The consequences of altered microbiota in immune-related chronic kidney disease.
Topics: Animals; Dysbiosis; Gastrointestinal Microbiome; Indican; Renal Insufficiency, Chronic; Toxins, Biological | 2021 |
Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease.
Topics: Animals; Aristolochic Acids; Cresols; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Indican; JNK Mitogen-Activated Protein Kinases; Kidney Tubules; Mice, Inbred C57BL; Propolis; Renal Insufficiency, Chronic; Signal Transduction; Smad2 Protein; Smad3 Protein; Sulfuric Acid Esters; Transforming Growth Factor beta; Uremia | 2020 |
Neurobehavioral effects of uremic toxin-indoxyl sulfate in the rat model.
Topics: Animals; Central Nervous System; Dopamine; Indican; Kidney; Locomotion; Male; Maze Learning; Models, Animal; Nervous System Diseases; Norepinephrine; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Serotonin; Spatial Memory; Toxins, Biological; Uremia | 2020 |
Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment.
Topics: Adsorption; Animals; Carbon; Disease Models, Animal; Dynamins; Epithelial Cells; Gastrointestinal Agents; Humans; Indican; Interferon Regulatory Factor-1; Intestinal Diseases; Intestinal Mucosa; Kidney; Male; Mice; Mitophagy; Oxides; Permeability; Renal Elimination; Renal Insufficiency, Chronic; Tight Junctions | 2020 |
The relationship between blood metabolites of the tryptophan pathway and kidney function: a bidirectional Mendelian randomization analysis.
Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Indican; Indoles; Kynurenine; Mendelian Randomization Analysis; Renal Insufficiency, Chronic; Tryptophan | 2020 |
New oral spherical carbon adsorbent effectively reduces serum indoxyl sulfate levels in moderate to advanced chronic kidney disease patients: a multicenter, prospective, open-label study.
Topics: Adsorption; Aged; Carbon; Female; Glomerular Filtration Rate; Hemoglobins; Humans; Indican; Kidney Failure, Chronic; Male; Microspheres; Middle Aged; Prospective Studies; Renal Insufficiency, Chronic; Severity of Illness Index | 2020 |
Influence of bowel habits on gut-derived toxins in peritoneal dialysis patients.
Topics: Cresols; Cross-Sectional Studies; Habits; Humans; Indican; Middle Aged; Peritoneal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters | 2020 |
Indoxyl Sulfate Contributes to Adipose Tissue Inflammation through the Activation of NADPH Oxidase.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Carbon; Chemokine CCL2; Indican; Inflammation; Male; Mice; Mice, Inbred ICR; NADPH Oxidases; Oxidative Stress; Oxides; Reactive Oxygen Species; Receptors, G-Protein-Coupled; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha | 2020 |
The role of TRPM7 in vascular calcification: Comparison between phosphate and uremic toxin.
Topics: Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Humans; Indican; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphates; Protein Serine-Threonine Kinases; Receptors, Calcitriol; Renal Insufficiency, Chronic; TRPM Cation Channels; Vascular Calcification | 2020 |
Effects of repeated increasing doses of cisplatin as models of acute kidney injury and chronic kidney disease in rats.
Topics: Acute Kidney Injury; Albuminuria; Animals; Antineoplastic Agents; Caspase 3; Cisplatin; Creatinine; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acid-Binding Proteins; Indican; Kidney; Male; NF-E2-Related Factor 2; Phosphorus; Rats, Wistar; Renal Insufficiency, Chronic; Urea; Uric Acid | 2021 |
Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function.
Topics: Animals; Diet; Dietary Proteins; Disease Models, Animal; Disease Progression; Escherichia coli; Gastrointestinal Microbiome; Hydrogen Sulfide; Indican; Kidney; Mice; Protein Processing, Post-Translational; Proteome; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophanase | 2020 |
Indoxyl sulfate promotes osteogenic differentiation of vascular smooth muscle cells by miR-155-5p-dependent downregulation of matrix Gla protein via ROS/NF-κB signaling.
Topics: Animals; Calcium-Binding Proteins; Cell Differentiation; Extracellular Matrix Proteins; Gene Expression Regulation; Humans; Indican; Matrix Gla Protein; MicroRNAs; Muscle, Smooth, Vascular; NF-kappa B; Osteogenesis; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Renal Insufficiency, Chronic; Vascular Calcification | 2020 |
A comparative and simultaneous analysis of indoxyl sulfate and sodium butyrate in human plasma by SPE and HPLC methods for kidney patients.
Topics: Butyric Acid; Chromatography, High Pressure Liquid; Humans; Indican; Limit of Detection; Linear Models; Nanotubes, Carbon; Renal Insufficiency, Chronic; Reproducibility of Results; Solid Phase Extraction | 2020 |
Targeting the gut microbial metabolic pathway with small molecules decreases uremic toxin production.
Topics: Animals; Bacteria; Electron Transport; Electron Transport Complex I; Escherichia coli; Flavonoids; Gastrointestinal Microbiome; Glycosides; Glycosylation; Humans; Indican; Indoles; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Proton-Motive Force; Quercetin; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Structure-Activity Relationship; Toxins, Biological; Tryptophan | 2020 |
Resveratrol Rescue Indoxyl Sulfate-Induced Deterioration of Osteoblastogenesis via the Aryl Hydrocarbon Receptor /MAPK Pathway.
Topics: Animals; Bone and Bones; Cell Differentiation; Humans; Indican; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Osteoblasts; Osteogenesis; Phosphorylation; Protective Agents; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Resveratrol; Signal Transduction | 2020 |
Serum indoxyl sulfate concentrations associate with progression of chronic kidney disease in children.
Topics: Adolescent; Biomarkers; Child; Cresols; Disease Progression; Female; Humans; Indican; Kaplan-Meier Estimate; Male; Proportional Hazards Models; Prospective Studies; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Survival Analysis | 2020 |
MicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease.
Topics: Adult; Aged; Aged, 80 and over; Animals; Carotid Arteries; Carotid Artery Injuries; Case-Control Studies; Cell Communication; Cell Proliferation; Cells, Cultured; Coronary Artery Disease; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Extracellular Vesicles; Female; Humans; Indican; Male; Mice, Inbred C57BL; MicroRNAs; Middle Aged; Renal Insufficiency, Chronic | 2022 |
Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.
Topics: Aged; Albuminuria; Chromatography, Liquid; Cohort Studies; Cresols; Female; Glomerular Filtration Rate; Glycine; Heart Failure; Humans; Incidence; Indican; Kidney Tubules; Kynurenic Acid; Male; Middle Aged; Myocardial Infarction; Organic Anion Transporters; Proportional Hazards Models; Prospective Studies; Pyridoxic Acid; Renal Insufficiency, Chronic; Ribonucleosides; Stroke; Sulfuric Acid Esters; Tandem Mass Spectrometry; Xanthines | 2021 |
Indoxyl Sulfate Mediates the Low Inducibility of the NLRP3 Inflammasome in Hemodialysis Patients.
Topics: Aged; Case-Control Studies; Caspase 1; Female; Gene Expression Regulation; Humans; Indican; Inflammasomes; Interleukin-1beta; Leukocytes, Mononuclear; Macrophages; Male; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein; Renal Dialysis; Renal Insufficiency, Chronic; THP-1 Cells | 2021 |
Synbiotics Alleviate the Gut Indole Load and Dysbiosis in Chronic Kidney Disease.
Topics: Adenine; Aged; Animals; Bacteria; Biodiversity; Body Weight; Diet; Disease Models, Animal; Dysbiosis; Feces; Female; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Indican; Indoles; Kidney; Male; Middle Aged; Rats; Renal Insufficiency, Chronic; Synbiotics; Time Factors | 2021 |
P
Topics: Cells, Cultured; Cellular Senescence; Chronic Kidney Disease-Mineral and Bone Disorder; Cresols; Healthy Volunteers; Humans; Indican; Mesenchymal Stem Cells; Osteogenesis; Primary Cell Culture; Renal Insufficiency, Chronic; Toxins, Biological; Uremia | 2021 |
The role of AMP-activated protein kinase α1-mediated endoplasmic reticulum stress in alleviating the toxic effect of uremic toxin indoxyl sulfate on vascular endothelial cells by Klotho.
Topics: AMP-Activated Protein Kinases; Apoptosis; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Indican; Intercellular Adhesion Molecule-1; Klotho Proteins; Renal Insufficiency, Chronic; RNA, Small Interfering; Transcription Factor CHOP; Uremic Toxins; Vascular Cell Adhesion Molecule-1 | 2021 |
Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response.
Topics: Animals; bcl-2-Associated X Protein; Cyclooxygenase 2; Gene Expression Regulation; Indican; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Oxidative Stress; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha; Tyrosine | 2021 |
Free p-cresyl sulfate shows the highest association with cardiovascular outcome in chronic kidney disease.
Topics: Cresols; Humans; Indican; Renal Insufficiency, Chronic; Sulfates; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2021 |
Association between the uremic toxins indoxyl-sulfate and p-cresyl-sulfate with sarcopenia and malnutrition in elderly patients with advanced chronic kidney disease.
Topics: Aged; Cresols; Humans; Indican; Indoles; Malnutrition; Renal Insufficiency, Chronic; Sarcopenia; Sulfates | 2021 |
pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro.
Topics: Calorimetry; Circular Dichroism; Cresols; Humans; Hydrogen-Ion Concentration; Indican; Indoleacetic Acids; Protein Binding; Protein Conformation; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin, Human; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2021 |
The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients.
Topics: Acute Coronary Syndrome; Cardiovascular System; Chemokines, CC; Cresols; Cysteine Endopeptidases; Female; Fibroblast Growth Factor-23; Heparan Sulfate Proteoglycans; Humans; Indican; Macrophage Inflammatory Proteins; Male; Middle Aged; Protein Binding; Renal Dialysis; Renal Insufficiency, Chronic; Signaling Lymphocytic Activation Molecule Family; Sulfuric Acid Esters; Toxins, Biological | 2021 |
Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbon; Cell Survival; Cognitive Dysfunction; Corticosterone; Depression; Indican; Injections, Intraperitoneal; Interleukin-1beta; Male; Mice, Inbred C57BL; Nephrectomy; Neural Stem Cells; Neurogenesis; Oxidative Stress; Oxides; Prefrontal Cortex; Renal Insufficiency, Chronic; Repressor Proteins; RNA, Messenger; Serotonin | 2021 |
The Administration of the Synbiotic
Topics: Animals; Creatinine; Disease Models, Animal; Disease Progression; Female; Fibrosis; Heart Diseases; Indican; Inulin; Kidney; Lactobacillus delbrueckii; Myocardium; Oligosaccharides; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Synbiotics; Toxins, Biological | 2021 |
Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Biomarkers; Carotid-Femoral Pulse Wave Velocity; Comorbidity; Cross-Sectional Studies; Disease Susceptibility; Female; Humans; Indican; Kidney Function Tests; Logistic Models; Male; Middle Aged; Multivariate Analysis; Renal Insufficiency, Chronic; Risk Factors; Vascular Stiffness | 2021 |
Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress.
Topics: Aged; Bacteria; Gastrointestinal Microbiome; Humans; Indican; Inflammation; Interleukin-6; Malondialdehyde; Middle Aged; Oxidative Stress; Renal Dialysis; Renal Insufficiency, Chronic; Sarcopenia; Uremia; Uremic Toxins | 2021 |
Circulating
Topics: Alkaline Phosphatase; Biomarkers; Bone and Bones; Bone Diseases; Cresols; Fractures, Bone; Humans; Indican; Middle Aged; Minerals; Renal Dialysis; Renal Insufficiency, Chronic; Sulfates; Sulfuric Acid Esters; Toxins, Biological; Uremia; Uremic Toxins | 2021 |
Impaired Tubular Secretion of Organic Solutes in Advanced Chronic Kidney Disease.
Topics: Adult; Aged; Creatinine; Cresols; Female; Glomerular Filtration Rate; Glutamine; Hippurates; Humans; Indican; Kidney Tubules; Male; Metabolomics; Middle Aged; Renal Insufficiency, Chronic; Solubility; Uremic Toxins | 2021 |
Comment on Indoxyl Sulfate-Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358.
Topics: Biomarkers; Humans; Indican; Renal Insufficiency, Chronic; Toxins, Biological | 2017 |
The effect of swimming exercise on adenine-induced kidney disease in rats, and the influence of curcumin or lisinopril thereon.
Topics: Adenine; Animals; Antioxidants; Blood Pressure; Creatinine; Curcumin; Disease Models, Animal; Female; Immunohistochemistry; Indican; Kidney; Lisinopril; Physical Conditioning, Animal; Protective Agents; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Serum Albumin; Swimming; Urea | 2017 |
DNA hypermethylation of sFRP5 contributes to indoxyl sulfate-induced renal fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; DNA Methylation; Eye Proteins; Fibrosis; Humans; Indican; Kidney; MAP Kinase Signaling System; Membrane Proteins; Reactive Oxygen Species; Renal Insufficiency, Chronic; Wnt Signaling Pathway | 2017 |
Exploring binding characteristics and the related competition of different protein-bound uremic toxins.
Topics: Binding, Competitive; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Hippurates; Humans; Indican; Indoleacetic Acids; Protein Binding; Protein Processing, Post-Translational; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin; Sulfuric Acid Esters; Tandem Mass Spectrometry; Toxins, Biological; Uremia | 2017 |
Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction.
Topics: Animals; Antioxidants; Biomarkers; Cell Line; Chromatography, High Pressure Liquid; Creatinine; Cytokines; Disease Models, Animal; Humans; Indican; Inflammation Mediators; Male; Mice; Mitochondria; Myoblasts; Nitrogen; Phosphorylation; Proto-Oncogene Proteins c-akt; Renal Insufficiency, Chronic; Sarcopenia | 2017 |
Indole 3-acetic acid, indoxyl sulfate and paracresyl-sulfate do not influence anemia parameters in hemodialysis patients.
Topics: Aged; Aged, 80 and over; Anemia; Biomarkers; Cross-Sectional Studies; Female; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Renal Dialysis; Renal Insufficiency, Chronic; Sulfates | 2017 |
The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease.
Topics: Adenine; Animals; Disease Models, Animal; Gene Expression Regulation; Hep G2 Cells; Hepcidins; Humans; Indican; Iron; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Renal Insufficiency, Chronic | 2018 |
Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Arginine; beta 2-Microglobulin; Creatinine; Female; Hemodialysis Solutions; Hippurates; Humans; Indican; Male; Middle Aged; Observer Variation; Phosphorus; Renal Dialysis; Renal Insufficiency, Chronic; Toxins, Biological; Urea; Uric Acid | 2017 |
Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling.
Topics: Albumins; Animals; ATP Binding Cassette Transporter, Subfamily B; Cyclosporine; Disease Models, Animal; Female; Gene Expression; Heart Transplantation; Hep G2 Cells; Humans; Immunosuppressive Agents; Indican; Kidney Transplantation; Liver; Male; Mice; Middle Aged; Multidrug Resistance-Associated Protein 2; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; RNA, Messenger; Signal Transduction; Up-Regulation | 2018 |
Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Indican; Kynurenine; Male; Metabolomics; Middle Aged; Pattern Recognition, Automated; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Signal Transduction; Thromboplastin; Thrombosis; Uremia; Vascular System Injuries | 2018 |
Aryl hydrocarbon receptor is activated in patients and mice with chronic kidney disease.
Topics: Adult; Aged; Aged, 80 and over; Animals; Basic Helix-Loop-Helix Transcription Factors; Cardiovascular Diseases; Case-Control Studies; Cause of Death; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Disease Models, Animal; Female; Humans; Indican; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Prospective Studies; Receptors, Aryl Hydrocarbon; Renal Dialysis; Renal Insufficiency, Chronic; Repressor Proteins; Risk Factors; Treatment Outcome | 2018 |
Plasma indoxyl sulfate concentration predicts progression of chronic kidney disease in dogs and cats.
Topics: Animals; Biomarkers; Blood Urea Nitrogen; Cat Diseases; Cats; Creatinine; Disease Progression; Dog Diseases; Dogs; Indican; Phosphates; Renal Insufficiency, Chronic; Species Specificity | 2018 |
Does Low-Protein Diet Influence the Uremic Toxin Serum Levels From the Gut Microbiota in Nondialysis Chronic Kidney Disease Patients?
Topics: Adult; Aged; Cresols; Diet, Protein-Restricted; Feces; Female; Gastrointestinal Microbiome; Humans; Indican; Indoleacetic Acids; Longitudinal Studies; Male; Middle Aged; Patient Compliance; Renal Insufficiency, Chronic; Sulfuric Acid Esters | 2018 |
Extended Duration Nocturnal Hemodialysis and Changes in Plasma Metabolite Profiles.
Topics: Acetylcarnitine; Adult; Aged; Amino Acids, Branched-Chain; Case-Control Studies; Cresols; Female; Humans; Indican; Longitudinal Studies; Male; Metabolome; Methylamines; Middle Aged; Prospective Studies; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Time Factors | 2018 |
Intestinal secretion of indoxyl sulfate as a possible compensatory excretion pathway in chronic kidney disease.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Caco-2 Cells; Humans; Indican; Intestinal Secretions; Jejunum; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Sodium-Phosphate Cotransporter Proteins, Type I | 2018 |
Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.
Topics: Adenine; Adenosine Triphosphate; Analysis of Variance; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Chromatography, Liquid; Disease Models, Animal; Disease Progression; Gene Knockout Techniques; Half-Life; HEK293 Cells; Humans; Indican; Mice; Mice, Knockout; Neoplasm Proteins; Renal Elimination; Renal Insufficiency, Chronic; Tandem Mass Spectrometry; Toxins, Biological; Transport Vesicles | 2018 |
Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biomarkers; Cell Proliferation; Cell Survival; Cells, Cultured; Cresols; Humans; Indican; Mesenchymal Stem Cells; Mice; Oxidants; Oxidative Stress; Peptide Fragments; Renal Insufficiency, Chronic; Sodium-Potassium-Exchanging ATPase | 2018 |
Indoxyl glucuronide, a protein-bound uremic toxin, inhibits hypoxia-inducible factor‒dependent erythropoietin expression through activation of aryl hydrocarbon receptor.
Topics: Cell Survival; Cytochrome P-450 CYP1A1; Erythropoietin; Gene Expression Regulation; Glucuronates; Hep G2 Cells; Humans; Indican; Indoles; Protein Binding; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; Signal Transduction; Transcriptional Activation; Uremia | 2018 |
Uremia Impacts VE-Cadherin and ZO-1 Expression in Human Endothelial Cell-to-Cell Junctions.
Topics: Antigens, CD; Cadherins; Cell Line; Cresols; Endothelial Cells; Female; Humans; Indican; Intercellular Junctions; Male; Middle Aged; Phosphates; Renal Artery; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia; Zonula Occludens-1 Protein | 2018 |
The relationship between serum indoxyl sulfate and the renal function after catheter ablation of atrial fibrillation in patients with mild renal dysfunction.
Topics: Aged; Atrial Fibrillation; Biomarkers; Catheter Ablation; Chromatography, High Pressure Liquid; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Indican; Male; Middle Aged; Postoperative Period; Renal Insufficiency, Chronic; Retrospective Studies; Risk Factors; Severity of Illness Index | 2019 |
Endothelial cells exposed to phosphate and indoxyl sulphate promote vascular calcification through interleukin-8 secretion.
Topics: Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Human Umbilical Vein Endothelial Cells; Humans; Indican; Interleukin-8; Male; Myocytes, Smooth Muscle; Phosphates; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Vascular Calcification | 2019 |
The fecal microbiome and serum concentrations of indoxyl sulfate and p-cresol sulfate in cats with chronic kidney disease.
Topics: Animals; Case-Control Studies; Cat Diseases; Cats; Cresols; Cross-Sectional Studies; Feces; Female; Gastrointestinal Microbiome; Indican; Male; Prospective Studies; Renal Insufficiency, Chronic; RNA, Ribosomal, 16S; Severity of Illness Index; Sulfuric Acid Esters | 2019 |
Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease.
Topics: Adult; Arterial Pressure; Cardiac Output; Cresols; Exercise; Glucuronides; Heart Diseases; Heart Rate; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2018 |
Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.
Topics: Adaptor Proteins, Signal Transducing; Animals; Atherosclerosis; Calcium-Binding Proteins; Disease Models, Animal; Humans; Indican; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Macrophage Activation; Macrophages; Male; Membrane Proteins; Mice; Mice, Knockout; Organic Anion Transporters; Phenotype; Plaque, Atherosclerotic; RAW 264.7 Cells; Receptors, LDL; Receptors, Notch; Renal Insufficiency, Chronic; Signal Transduction; Vascular Calcification | 2019 |
The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease.
Topics: Adult; Aged; Antibodies; Antihypertensive Agents; Biomarkers; Blood Pressure; C-Reactive Protein; Creatinine; Drug Therapy, Combination; E-Selectin; Female; Ferritins; Humans; Hypertension; Indican; Inflammation; Interleukin-6; Lipoproteins, LDL; Lymphocyte Count; Male; Middle Aged; Neopterin; Neutrophils; Oxidative Stress; P-Selectin; Renal Insufficiency, Chronic; Superoxide Dismutase-1; Tumor Necrosis Factor-alpha | 2019 |
Protein-Bound Solute Clearance During Hemodialysis.
Topics: Hemodiafiltration; Humans; Indican; Renal Dialysis; Renal Insufficiency, Chronic; Toxins, Biological | 2019 |
Improved dialysis removal of protein-bound uremic toxins by salvianolic acids.
Topics: Alkenes; Animals; Binding, Competitive; Cresols; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Indican; Male; Microdialysis; Polyphenols; Protein Binding; Proteins; Rats, Sprague-Dawley; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2019 |
The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease.
Topics: Animals; Case-Control Studies; Cat Diseases; Cats; Chromatography, High Pressure Liquid; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Indican; Male; Renal Insufficiency, Chronic; Retrospective Studies; Severity of Illness Index | 2019 |
Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Disease Progression; Female; Humans; Indican; Male; Mass Spectrometry; Middle Aged; Multivariate Analysis; Renal Insufficiency, Chronic; ROC Curve; Taiwan; Tertiary Care Centers | 2019 |
Indoxyl Sulfate and p-Cresyl Sulfate Promote Vascular Calcification and Associate with Glucose Intolerance.
Topics: Animals; Biological Products; Biopsy, Needle; Carbamates; Disease Models, Animal; Glucose Intolerance; Immunohistochemistry; Indican; Male; Metformin; Polyesters; Random Allocation; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Sensitivity and Specificity; Vascular Calcification | 2019 |
Bowel Habits and the Association With Uremic Toxins in Non-Dialysis-Dependent Chronic Kidney Disease Patients.
Topics: Constipation; Cresols; Cross-Sectional Studies; Defecation; Female; Humans; Indican; Male; Middle Aged; Renal Insufficiency, Chronic; Sulfuric Acid Esters | 2020 |
Measuring serum total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease using UPLC-MS/MS.
Topics: Adult; Chromatography, High Pressure Liquid; Cresols; Female; Humans; Indican; Kidney Function Tests; Male; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Tandem Mass Spectrometry; Young Adult | 2019 |
Serum Concentration of Indoxyl Sulfate in Peritoneal Dialysis Patients and Low-Flux Hemodialysis Patients.
Topics: Adult; Aged; Cross-Sectional Studies; Female; Humans; Indican; Male; Middle Aged; Peritoneal Dialysis; Renal Dialysis; Renal Insufficiency, Chronic | 2019 |
Effect of Indoxyl Sulfate on the Repair and Intactness of Intestinal Epithelial Cells: Role of Reactive Oxygen Species' Release.
Topics: Animals; Antioxidants; Carbon; Cell Movement; Cell Survival; Connexin 43; Epithelial Cells; Humans; Indican; Intestines; NF-E2-Related Factor 2; Oxidative Stress; Oxides; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Uremia | 2019 |
Klotho restrain RIG-1/NF-κB signaling activation and monocyte inflammatory factor release under uremic condition.
Topics: Adult; Animals; Blotting, Western; DEAD Box Protein 58; Female; Glucuronidase; Humans; Indican; Inflammation; Interleukin-6; Kidney; Klotho Proteins; Male; Mice; Mice, Inbred BALB C; Middle Aged; Monocytes; NF-kappa B; Receptors, Immunologic; Renal Insufficiency, Chronic; Signal Transduction; THP-1 Cells; Tumor Necrosis Factor-alpha; Uremia | 2019 |
Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes.
Topics: Biological Transport; Cresols; Erythrocytes; Hippurates; Humans; Indican; Indoleacetic Acids; Protein Binding; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Uremia | 2019 |
Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway.
Topics: Adult; Aged; Aged, 80 and over; Benzoquinones; Case-Control Studies; Cells, Cultured; Dioxins; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Indican; Indoleacetic Acids; Lactams, Macrocyclic; Leukocytes, Mononuclear; Male; Middle Aged; Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Renal Insufficiency, Chronic; RNA, Small Interfering; Signal Transduction; Thromboplastin; Tissue Array Analysis; Umbilical Veins; Up-Regulation | 2013 |
Decrease in irisin in patients with chronic kidney disease.
Topics: Case-Control Studies; Creatinine; Demography; Female; Fibronectins; Humans; Indican; Male; Middle Aged; Muscle Cells; Muscle, Skeletal; Renal Insufficiency, Chronic | 2013 |
Editorial: A missing link? Monocyte activation by uremic toxins in cardiorenal syndrome.
Topics: Animals; Carbon; Gastrointestinal Agents; Humans; Indican; Inflammation; Male; Monocytes; Oxides; Renal Insufficiency, Chronic | 2013 |
Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia.
Topics: Animals; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Indican; Mice; p300-CBP Transcription Factors; Rats; Renal Insufficiency, Chronic; RNA, Messenger; Signal Transduction; Uremia | 2013 |
Beraprost sodium improves survival rates in anti-glomerular basement membrane glomerulonephritis and 5/6 nephrectomized chronic kidney disease rats.
Topics: Animals; Aorta; Cyclic AMP; Endothelial Cells; Epoprostenol; Glomerular Basement Membrane; Glomerulonephritis; Humans; Indican; Male; Nephrectomy; Rats; Renal Insufficiency, Chronic; Survival Analysis | 2013 |
Protein-bound uremic toxins stimulate crosstalk between leukocytes and vessel wall.
Topics: Animals; Capillary Permeability; Cell Adhesion; Cell Communication; Cresols; Endothelium, Vascular; Female; Glucuronides; Hemodynamics; Indican; Leukocyte Rolling; Leukocytes; Lipopolysaccharides; Peritoneum; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Respiratory Burst; Sulfuric Acid Esters; Uremia | 2013 |
Association of indoxyl sulfate with fibroblast growth factor 23 in patients with advanced chronic kidney disease.
Topics: Aged; Biomarkers; Cross-Sectional Studies; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Humans; Indican; Male; Middle Aged; Renal Insufficiency, Chronic | 2014 |
The uremic toxin indoxyl sulphate enhances macrophage response to LPS.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcium; Cell Proliferation; Cytokines; Escherichia coli; Female; Homeostasis; Indican; Lipopolysaccharides; Macrophage Activation; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nitric Oxide; Nitric Oxide Synthase Type II; Reactive Oxygen Species; Renal Insufficiency, Chronic | 2013 |
The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation.
Topics: Amidines; Antioxidants; Atherosclerosis; Copper; Hemin; Humans; Hydrogen Peroxide; Indican; Lipid Peroxidation; Lipid Peroxides; Lipoproteins, LDL; Oxidation-Reduction; Oxidative Stress; Peroxidase; Quinazolines; Renal Insufficiency, Chronic; Uremia | 2014 |
Indoxyl sulfate-induced activation of (pro)renin receptor is involved in expression of TGF-β1 and α-smooth muscle actin in proximal tubular cells.
Topics: Actins; Animals; Carbon; Cell Line; Chelating Agents; Disease Models, Animal; Fibrosis; Humans; Hypertension, Renal; Indican; Kidney Tubules, Proximal; Male; Oxides; Prorenin Receptor; Random Allocation; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Renal Insufficiency, Chronic; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Transforming Growth Factor beta1; Up-Regulation | 2014 |
Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells.
Topics: Acetylcysteine; Angiotensins; Animals; Down-Regulation; Humans; Immunohistochemistry; Indican; Kidney Tubules, Proximal; Male; Models, Biological; Nitric Oxide Synthase Type III; Organic Anion Transporters, Sodium-Independent; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats, Inbred Dahl; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Receptors, G-Protein-Coupled; Renal Insufficiency, Chronic; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Time Factors; Transforming Growth Factor beta1 | 2014 |
Protein-bound uremic toxins, inflammation and oxidative stress: a cross-sectional study in stage 3-4 chronic kidney disease.
Topics: Aged; Antioxidants; Biomarkers; Blood Proteins; Cardiovascular Diseases; Cresols; Cross-Sectional Studies; Female; Humans; Indican; Inflammation; Interleukin-6; Male; Middle Aged; Oxidative Stress; Renal Insufficiency, Chronic; Risk Reduction Behavior; Sulfuric Acid Esters; Toxins, Biological; Uremia; Vascular Stiffness | 2014 |
Uraemic toxins and cardiovascular disease across the chronic kidney disease spectrum: an observational study.
Topics: Aged; Biomarkers; Brachial Artery; Cardiovascular Diseases; Carotid Intima-Media Thickness; Cresols; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Indican; Kidney Failure, Chronic; Logistic Models; Male; Middle Aged; Multivariate Analysis; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors; Sulfuric Acid Esters; Vascular Stiffness | 2014 |
Serum metabolomic profiling and incident CKD among African Americans.
Topics: Biomarkers; Black or African American; Chromatography, Liquid; Creatine; Cross-Sectional Studies; Deoxyglucose; Female; Gas Chromatography-Mass Spectrometry; Humans; Incidence; Indican; Kidney; Linear Models; Longitudinal Studies; Male; Metabolomics; Middle Aged; Proportional Hazards Models; Pyrrolidonecarboxylic Acid; Renal Insufficiency, Chronic; Risk Factors; Time Factors; United States | 2014 |
Uremic toxicity and sclerostin in chronic kidney disease patients.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aortography; Arteriosclerosis; beta 2-Microglobulin; Biomarkers; Bone Morphogenetic Proteins; Calcinosis; Cresols; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Follow-Up Studies; Genetic Markers; Humans; Indican; Inflammation; Male; Middle Aged; Pulse Wave Analysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Survival Analysis; Tomography, Spiral Computed; Uremia; Vascular Stiffness | 2014 |
Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells.
Topics: Animals; Aorta; Cell Proliferation; Gene Expression Regulation; Humans; Indican; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Onium Compounds; Organic Anion Transporters, Sodium-Independent; Rats; Receptors, Cell Surface; Renal Insufficiency, Chronic; RNA, Small Interfering; Thromboplastin; Vacuolar Proton-Translocating ATPases | 2014 |
In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Breast Neoplasms; Caco-2 Cells; Chlorophyll; Humans; In Vitro Techniques; Indican; Intestinal Mucosa; Intestinal Secretions; Kidney; Neoplasm Proteins; Real-Time Polymerase Chain Reaction; Renal Insufficiency, Chronic; RNA, Messenger; Up-Regulation; Uric Acid | 2015 |
ROS and oxidative stress in CKD patients: is it the mitochondria that keeps CKD patients in bed?
Topics: Animals; Carbon; Indican; Male; Muscle, Skeletal; Oxidative Stress; Oxides; Renal Insufficiency, Chronic | 2015 |
Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Female; Glucuronidase; Humans; Hypertrophy, Left Ventricular; Indican; Klotho Proteins; Male; Mice; Mice, Inbred C57BL; Middle Aged; Renal Insufficiency, Chronic; Young Adult | 2015 |
Loss of Klotho in CKD Breaks One's Heart.
Topics: Animals; Female; Glucuronidase; Humans; Hypertrophy, Left Ventricular; Indican; Male; Renal Insufficiency, Chronic | 2015 |
Indoxyl sulfate, not P-cresyl sulfate, is associated with advanced glycation end products in patients on long-term hemodialysis.
Topics: Aged; Biomarkers; Creatinine; Cresols; Cross-Sectional Studies; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Indican; Male; Middle Aged; Regression Analysis; Renal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Treatment Outcome | 2015 |
AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress.
Topics: Animals; Carbon; Indican; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts; Oxidation-Reduction; Oxidative Stress; Oxides; Physical Conditioning, Animal; Quality of Life; Renal Insufficiency, Chronic; Superoxides | 2015 |
Uremic retention solute indoxyl sulfate level is associated with prolonged QTc interval in early CKD patients.
Topics: Action Potentials; Aged; Animals; Cell Line; Computer Simulation; Electrocardiography; Female; Humans; Indican; Male; Middle Aged; Models, Biological; Myocytes, Cardiac; Phosphorylation; Prospective Studies; Rats; Renal Insufficiency, Chronic; Shab Potassium Channels | 2015 |
[Effect of serum from patients with chronic renal insufficiency and indoxyl sulfate on lipid accumulation in macrophages in vitro].
Topics: Animals; Apolipoproteins E; Cell Line; Foam Cells; Humans; Indican; Lipids; Macrophages; Mice; Mice, Inbred C57BL; Plaque, Atherosclerotic; Renal Insufficiency, Chronic | 2015 |
Indoxyl sulfate exacerbates low bone turnover induced by parathyroidectomy in young adult rats.
Topics: Animals; Bone Density; Bone Remodeling; Disease Models, Animal; Indican; Male; Parathyroid Hormone; Parathyroidectomy; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2015 |
Left ventricular global longitudinal strain is associated with cardiovascular risk factors and arterial stiffness in chronic kidney disease.
Topics: Aged; Body Mass Index; Cresols; Cross-Sectional Studies; Diabetes Mellitus; Exercise Test; Female; Glomerular Filtration Rate; Heart Failure; Humans; Indican; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors; Sulfuric Acid Esters; Ultrasonography; Vascular Stiffness; Ventricular Dysfunction, Left | 2015 |
Uric acid, indoxyl sulfate, and methylguanidine activate bulbospinal neurons in the RVLM via their specific transporters and by producing oxidative stress.
Topics: Animals; Anion Transport Proteins; Benzoxazoles; Enzyme Inhibitors; Indican; Medulla Oblongata; Membrane Glycoproteins; Membrane Potentials; Methylguanidine; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Neurons; Neuroprotective Agents; Neurotoxins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Oxidative Stress; Patch-Clamp Techniques; Rats, Wistar; Renal Insufficiency, Chronic; Sympathetic Nervous System; Triazoles; Uric Acid | 2015 |
The Role of Liver in Determining Serum Colon-Derived Uremic Solutes.
Topics: Aged; Animals; Cohort Studies; Colon; Cresols; Disease Models, Animal; Female; Gastrointestinal Tract; Humans; Indican; Kidney; Linear Models; Liver; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Treatment Outcome; Uremia | 2015 |
Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate.
Topics: Atherosclerosis; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Survival; Cholesterol; Cytokines; Down-Regulation; Humans; Hydrocarbons, Fluorinated; Indican; Liver X Receptors; Macrophages; Orphan Nuclear Receptors; Reactive Oxygen Species; Renal Insufficiency, Chronic; Sulfonamides | 2015 |
Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients.
Topics: Aged; Biomarkers; Carbon; Cresols; Dinoprost; Female; Humans; Indican; Male; Middle Aged; Oxidative Stress; Oxides; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin; Sulfuric Acid Esters; Toxins, Biological; Uremia | 2015 |
Deleterious vascular effects of indoxyl sulfate and reversal by oral adsorbent AST-120.
Topics: Administration, Oral; Adsorption; Animals; Aorta; Apolipoproteins E; Blood Pressure; Carbon; Cardiovascular Diseases; Cell Survival; Echocardiography; Endothelium, Vascular; Female; Human Umbilical Vein Endothelial Cells; Humans; Indican; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxides; Pulse Wave Analysis; Renal Insufficiency, Chronic; Uremia; Vascular Cell Adhesion Molecule-1 | 2015 |
Exploring Protein Binding of Uremic Toxins in Patients with Different Stages of Chronic Kidney Disease and during Hemodialysis.
Topics: Aged; Aged, 80 and over; Cresols; Cross-Sectional Studies; Female; Glucuronides; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Protein Binding; Renal Dialysis; Renal Insufficiency, Chronic; Serum Albumin; Severity of Illness Index; Sulfuric Acid Esters; Uremia | 2015 |
Grape seed proanthocyanidin extract protects human umbilical vein endothelial cells from indoxyl sulfate-induced injury via ameliorating mitochondrial dysfunction.
Topics: Antigens, CD; Apoptosis; Cadherins; Cardiovascular Diseases; Drug Evaluation, Preclinical; Endothelial Cells; Grape Seed Extract; Human Umbilical Vein Endothelial Cells; Humans; Indican; Mitochondria; Nitric Oxide Synthase Type III; Phytotherapy; Proanthocyanidins; Reactive Oxygen Species; Renal Insufficiency, Chronic; Vitis | 2016 |
Upregulation of nuclear factor-κB activity mediates CYP24 expression and reactive oxygen species production in indoxyl sulfate-induced chronic kidney disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Line, Tumor; Cytochrome P450 Family 24; Cytokines; Deoxyguanosine; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hypertension; Indican; Inflammation Mediators; Kidney; Oxidative Stress; Rats, Inbred Dahl; Reactive Oxygen Species; Renal Insufficiency, Chronic; RNA Interference; Transcription Factor RelA; Transfection; Up-Regulation | 2016 |
The uremic toxin indoxyl sulfate exacerbates reactive oxygen species production and inflammation in 3T3-L1 adipose cells.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Indican; Inflammation; Interleukin-6; Mice; NADPH Oxidases; Oxidative Stress; Reactive Oxygen Species; Renal Insufficiency, Chronic; Toxins, Biological; Tumor Necrosis Factor-alpha; Uremia | 2016 |
Indoxyl sulfate, not p-cresyl sulfate, is associated with cognitive impairment in early-stage chronic kidney disease.
Topics: Aged; Case-Control Studies; Cognition Disorders; Cresols; Executive Function; Female; Humans; Indican; Male; Middle Aged; Neuropsychological Tests; Renal Insufficiency, Chronic; Sulfuric Acid Esters | 2016 |
The harmful effect of indoxyl sulfate on neovascularization in chronic kidney disease.
Topics: Animals; Humans; Indican; Interleukin-10; Renal Insufficiency, Chronic; Signal Transduction; Vascular Endothelial Growth Factor A | 2016 |
Emodin via colonic irrigation modulates gut microbiota and reduces uremic toxins in rats with chronic kidney disease.
Topics: Animals; Emodin; Gastrointestinal Microbiome; Indican; Male; Microbiota; Random Allocation; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Therapeutic Irrigation; Urea | 2016 |
Reduced protein bound uraemic toxins in vegetarian kidney failure patients treated by haemodiafiltration.
Topics: Female; Hemodiafiltration; Humans; Indican; Male; Middle Aged; Renal Dialysis; Renal Insufficiency, Chronic; Urea; Vegetarians | 2016 |
LC-MS/MS method for simultaneous determination of serum p-cresyl sulfate and indoxyl sulfate in patients undergoing peritoneal dialysis.
Topics: Adult; Chromatography, High Pressure Liquid; Cresols; Female; Humans; Indican; Limit of Detection; Male; Middle Aged; Peritoneal Dialysis; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Tandem Mass Spectrometry | 2016 |
Increased Levels of Total p-Cresylsulfate Are Associated with Pruritus in Patients with Chronic Kidney Disease.
Topics: Aged; Biomarkers; Cresols; Cross-Sectional Studies; Disease Progression; Female; Glomerular Filtration Rate; Humans; Indican; Male; Middle Aged; Pruritus; Renal Insufficiency, Chronic; Sulfuric Acid Esters | 2016 |
The Uremic Toxin Indoxyl-3-Sulfate Induces CYP1A2 In Primary Human Hepatocytes.
Topics: Adult; Aged; Cells, Cultured; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Female; Hepatocytes; Humans; Indican; Indoleacetic Acids; Male; Omeprazole; Renal Insufficiency, Chronic; RNA, Messenger; Uremia | 2016 |
Correlations between Plasma Levels of Anionic Uremic Toxins and Clinical Parameters in Hemodialysis Patients.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Urea Nitrogen; Creatinine; Female; Furans; Glomerular Filtration Rate; Humans; Indican; Indoleacetic Acids; Male; Middle Aged; Predictive Value of Tests; Propionates; Renal Dialysis; Renal Insufficiency, Chronic | 2016 |
Uremic Toxin-Producing Gut Microbiota in Rats with Chronic Kidney Disease.
Topics: Animals; Bacteroidetes; Clostridium; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Indican; Male; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; RNA, Bacterial; RNA, Ribosomal, 16S; Sulfuric Acid Esters; Toxins, Biological | 2017 |
Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease.
Topics: Animals; Cell Line; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Glucuronidase; Humans; Indican; Kidney Failure, Chronic; Klotho Proteins; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Tandem Mass Spectrometry; Vascular Calcification | 2016 |
Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease.
Topics: Animals; Disease Models, Animal; Indican; Male; Mice; Muscle, Skeletal; Renal Insufficiency, Chronic; Sarcopenia; Uremia | 2016 |
Tryptophan metabolism, its relation to inflammation and stress markers and association with psychological and cognitive functioning: Tasmanian Chronic Kidney Disease pilot study.
Topics: Aged; Aged, 80 and over; Anxiety; Biomarkers; Cognition; Cross-Sectional Studies; Depression; Female; Glomerular Filtration Rate; Humans; Hydrocortisone; Indican; Indoleacetic Acids; Inflammation; Kynurenic Acid; Male; Middle Aged; Neopterin; Oxidative Stress; Pilot Projects; Prospective Studies; Renal Insufficiency, Chronic; Surveys and Questionnaires; Tasmania; Tryptophan | 2016 |
Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.
Topics: Animal Feed; Animals; Bacteria; Bacteroides; Diet; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Gastrointestinal Tract; Genetic Engineering; Germ-Free Life; Humans; Indican; Indoles; Metagenome; Mice; Microbiota; Renal Insufficiency, Chronic; Toxins, Biological; Tryptophan; Tryptophanase | 2016 |
Indoxyl Sulfate Impairs Endothelial Progenitor Cells and Might Contribute to Vascular Dysfunction in Patients with Chronic Kidney Disease.
Topics: Aged; Cells, Cultured; Cross-Sectional Studies; Diagnostic Techniques, Cardiovascular; Endothelial Progenitor Cells; Endothelium, Vascular; Female; Humans; Indican; Male; Middle Aged; Renal Insufficiency, Chronic | 2016 |
Indoxyl sulfate - the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease.
Topics: Adult; Aged; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Female; Hemostasis; Humans; Hydrogen Peroxide; Indican; Inflammation; Intercellular Adhesion Molecule-1; Lipoproteins; Male; Middle Aged; Neopterin; Oxidative Stress; Peptide Fragments; Plasminogen Activator Inhibitor 1; Prevalence; Prothrombin; Renal Insufficiency, Chronic; Thrombin; Thromboplastin; Tissue Plasminogen Activator; Urokinase-Type Plasminogen Activator; Vascular Cell Adhesion Molecule-1; von Willebrand Factor | 2017 |
Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease-associated thrombosis in mice.
Topics: Animals; Blood Platelets; Glucuronidase; Indican; Klotho Proteins; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Platelet Activation; Reactive Oxygen Species; Renal Insufficiency, Chronic; Thrombosis | 2017 |
Indoxyl sulfate potentiates endothelial dysfunction via reciprocal role for reactive oxygen species and RhoA/ROCK signaling in 5/6 nephrectomized rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Antioxidants; Cyclic N-Oxides; Endothelium, Vascular; Gene Expression Regulation; Humans; Indican; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Organophosphorus Compounds; Oxidative Stress; Piperidines; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Spin Labels | 2017 |
Indoxyl sulfate stimulates monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells by inducing oxidative stress through activation of the NADPH oxidase-nuclear factor-κB pathway.
Topics: Atherosclerosis; Cells, Cultured; Chemokine CCL2; Endothelial Cells; Humans; Indican; NADPH Oxidases; NF-kappa B; Oxidative Stress; Renal Insufficiency, Chronic; Signal Transduction; Umbilical Veins | 2010 |
Indoxyl sulfate-induced epithelial-to-mesenchymal transition and apoptosis of renal tubular cells as novel mechanisms of progression of renal disease.
Topics: Actins; Animals; Apoptosis; Cadherins; Cell Line; Cell Movement; Cell Proliferation; Disease Progression; Enzyme Activation; Epithelial-Mesenchymal Transition; Indican; Membrane Proteins; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Rats; Renal Insufficiency, Chronic; Signal Transduction; Zonula Occludens-1 Protein | 2012 |
Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate.
Topics: Animals; Carbon; Cardiomyopathies; Fibrosis; Indican; Male; Oxides; Random Allocation; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic | 2012 |
Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Chemokine CCL2; Flow Cytometry; Glucuronidase; Human Umbilical Vein Endothelial Cells; Humans; Immunoblotting; Indican; Klotho Proteins; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Renal Insufficiency, Chronic | 2012 |
Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy.
Topics: Adult; Aged; Biomarkers; Cardiomyopathy, Dilated; Disease Progression; Female; Heart Failure; Humans; Indican; Kaplan-Meier Estimate; Male; Middle Aged; Natriuretic Peptide, Brain; Predictive Value of Tests; Prognosis; Renal Insufficiency, Chronic; Risk Factors; Stroke Volume; Ultrasonography; Uremia | 2013 |
Association between AST-120 and abdominal aortic calcification in predialysis patients with chronic kidney disease.
Topics: Aged; Aorta, Abdominal; Aortic Diseases; Carbon; Cross-Sectional Studies; Female; Humans; Indican; Male; Middle Aged; Oxides; Renal Insufficiency, Chronic; Retrospective Studies; Tomography, X-Ray Computed; Vascular Calcification | 2013 |
Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MS(E).
Topics: Adenine; Animals; Chromatography, High Pressure Liquid; Cresols; Fatty Acids, Unsaturated; Fibrosis; Gene Expression; Indican; Kidney Function Tests; Kidney Tubules; Male; Metabolome; Rats; Renal Insufficiency, Chronic; Sulfuric Acid Esters; Tandem Mass Spectrometry; Transforming Growth Factor beta1 | 2013 |
Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction.
Topics: Aged; Biomarkers; Chromatography, High Pressure Liquid; Diastole; Disease Progression; Echocardiography; Female; Follow-Up Studies; Glomerular Filtration Rate; Heart Ventricles; Humans; Indican; Male; Prognosis; Prospective Studies; Renal Insufficiency, Chronic; Ventricular Dysfunction, Left; Ventricular Function, Left | 2013 |
A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients.
Topics: Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure Liquid; Cresols; Female; Furans; Glucuronides; Hippurates; Humans; Indican; Indoleacetic Acids; Male; Propionates; Renal Insufficiency, Chronic; Severity of Illness Index; Sulfuric Acid Esters; Tandem Mass Spectrometry; Uremia; Uric Acid | 2013 |
Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease.
Topics: Animals; Carbon; Cardiovascular Diseases; Cell Line; Disease Models, Animal; Flow Cytometry; Gastrointestinal Agents; Humans; Immunoblotting; Indican; Inflammation; Male; Mice; Mice, Inbred C57BL; Monocytes; Oxides; Reactive Oxygen Species; Renal Insufficiency, Chronic | 2013 |