Compounds > indazoles
Page last updated: 2024-08-21

indazoles and Triple Negative Breast Neoplasms

indazoles has been researched along with Triple Negative Breast Neoplasms in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's12 (85.71)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Lin, J; Yang, X; Zhao, H1
Bhat, V; Cescon, DW; Cruickshank, J; Hodgson, K; Parsyan, A; Pellizzari, S; Wakeham, D1
Mountzios, G; Papadimitriou, CA; Papadimitriou, M1
Kerbel, RS; Man, S; Reguera-Nuñez, E; Xu, P1
Ding, M; Fan, X; Fu, W; Hu, S; Lei, C; Li, T; Lin, F; Liu, S; Shen, Y; Tang, Y; Yang, Y; Ye, X; Yu, Y1
Chen, P; Cui, D; He, J; Huang, D; Jiang, L; Li, L; Ma, T; Qi, J; Schmitt, CA; Shao, S; Tao, R; Wang, J; Wu, C; Xiong, J; Yu, D; Yu, Y; Zhou, B1
Chrysikos, D; Dimopoulos, MA; Papadimitriou, CA; Psaltopoulou, T; Sergentanis, TN; Zagouri, F1
Aceto, N; Auricchio, N; Barber, P; Baselga, J; Bergamaschi, A; Bosch, A; Carey, LA; Castel, P; Elkabets, M; Ellis, H; Hazra, S; Juric, D; Kim, P; Lewis, JS; Maheswaran, S; Morse, N; Ng, T; Penault-Llorca, F; Perou, CM; Radosevic-Robin, N; Scaltriti, M; Singh, S; Tao, JJ; Viola-Villegas, NT; Vojnovic, B; Weitsman, G1
Chen, K; Gaur, S; Hu, S; Liu, YR; Pan, SL; Tzeng, HE; Wang, Y; Yang, L; Yen, Y1
Bartholomeusz, C; Hortobagyi, GN; Kai, K; Kondo, K; Masuda, H; Pitner, MK; Reyes, ME; Saya, H; Sen, S; Torres-Adorno, AM; Tripathy, D; Ueno, NT; Wang, X; Xie, X1
Bocci, G; Di Desidero, T; Kerbel, RS; Man, S; Xu, P1
Beijersbergen, RL; de Lint, K; Jastrzebski, K; Lieftink, C; Poell, JB; Soueidan, H; Vidal Rodriguez, J; Wessels, LF1
Carlson, JH; De, P; Dey, N; Leyland-Jones, B; Marcus, A; Wu, H1
Reed, DE; Shokat, KM1

Reviews

2 review(s) available for indazoles and Triple Negative Breast Neoplasms

ArticleYear
The role of PARP inhibition in triple-negative breast cancer: Unraveling the wide spectrum of synthetic lethality.
    Cancer treatment reviews, 2018, Volume: 67

    Topics: Benzamides; Female; Genes, BRCA1; Genes, BRCA2; Homologous Recombination; Humans; Indazoles; Phthalazines; Piperazines; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Triple Negative Breast Neoplasms

2018
Hsp90 inhibitors in breast cancer: a systematic review.
    Breast (Edinburgh, Scotland), 2013, Volume: 22, Issue:5

    Topics: Adenine; Antineoplastic Agents; Benzamides; Benzoquinones; Biomarkers, Tumor; Female; Glycine; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Indazoles; Isoxazoles; Lactams, Macrocyclic; Pyridines; Resorcinols; Triazoles; Triple Negative Breast Neoplasms

2013

Other Studies

12 other study(ies) available for indazoles and Triple Negative Breast Neoplasms

ArticleYear
BRCA Mutations and Homologous Recombination Repair Deficiency in Treatment With Niraparib Combined With Pembrolizumab.
    JAMA oncology, 2020, 03-01, Volume: 6, Issue:3

    Topics: Antibodies, Monoclonal, Humanized; Humans; Indazoles; Mutation; Piperidines; Recombinational DNA Repair; Triple Negative Breast Neoplasms

2020
Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer.
    Breast (Edinburgh, Scotland), 2021, Volume: 58

    Topics: Cell Line, Tumor; Cell Proliferation; Humans; Indazoles; Indoles; Protein Serine-Threonine Kinases; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2021
Preclinical impact of high dose intermittent antiangiogenic tyrosine kinase inhibitor pazopanib in intrinsically resistant tumor models.
    Angiogenesis, 2018, Volume: 21, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Indazoles; Kidney Neoplasms; Mice; Mice, SCID; Mice, Transgenic; Protein Kinase Inhibitors; Pyrimidines; Sulfonamides; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2018
EGFR/Notch Antagonists Enhance the Response to Inhibitors of the PI3K-Akt Pathway by Decreasing Tumor-Initiating Cell Frequency.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, 05-01, Volume: 25, Issue:9

    Topics: Animals; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Cell Proliferation; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins c-akt; Receptors, Notch; Sulfonamides; Triple Negative Breast Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2019
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer.
    Theranostics, 2019, Volume: 9, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cancer Survivors; Cell Line, Tumor; Cellular Senescence; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Delivery Systems; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Mice, Nude; Mixed Function Oxygenases; Proto-Oncogene Proteins; Pyridones; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2019
Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer.
    Science signaling, 2014, Mar-25, Volume: 7, Issue:318

    Topics: Antibodies, Monoclonal, Humanized; Blotting, Western; Cell Line, Tumor; Cetuximab; Dimerization; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunoglobulin G; Indazoles; Neuregulin-1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-akt; Pyrimidines; Receptor, ErbB-3; Signal Transduction; Sulfonamides; Triple Negative Breast Neoplasms

2014
The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor.
    Oncotarget, 2015, May-10, Volume: 6, Issue:13

    Topics: Animals; Apoptosis; beta Catenin; Blotting, Western; Cell Proliferation; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique; Humans; Indazoles; Mice; Mice, Nude; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazines; Pyridines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; TOR Serine-Threonine Kinases; Triple Negative Breast Neoplasms; Tumor Cells, Cultured; Wnt Proteins; Xenograft Model Antitumor Assays

2015
Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aurora Kinase A; Aurora Kinase B; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Female; Humans; Indazoles; Mice; Piperazines; Protein Kinase Inhibitors; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2015
Potent efficacy of metronomic topotecan and pazopanib combination therapy in preclinical models of primary or late stage metastatic triple-negative breast cancer.
    Oncotarget, 2015, Dec-15, Volume: 6, Issue:40

    Topics: Administration, Metronomic; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Female; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indazoles; Kaplan-Meier Estimate; Mice; Mice, SCID; Neoplasm Proteins; Neovascularization, Pathologic; Pyrimidines; Real-Time Polymerase Chain Reaction; Sulfonamides; Topotecan; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2015
Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R.
    Molecular cancer therapeutics, 2016, Volume: 15, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Gene Expression; Gene Knockdown Techniques; Humans; Indazoles; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Sulfonamides; Triple Negative Breast Neoplasms

2016
Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers.
    Oncotarget, 2016, Jul-12, Volume: 7, Issue:28

    Topics: Adenomatous Polyposis Coli Protein; beta Catenin; Brain Neoplasms; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dishevelled Proteins; Female; Fibronectins; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Integrins; Matrix Metalloproteinase 7; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Video; Mutation; Phenotype; RNA Interference; RNA, Small Interfering; Sulfonamides; Sulindac; Triple Negative Breast Neoplasms; Up-Regulation; Wnt Proteins; Wnt Signaling Pathway

2016
INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC.
    Molecular cancer research : MCR, 2017, Volume: 15, Issue:6

    Topics: Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Female; Humans; Indazoles; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sulfonamides; Triple Negative Breast Neoplasms

2017