Compounds > indazoles
Page last updated: 2024-08-21

indazoles and Seizures

indazoles has been researched along with Seizures in 65 studies

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.54)18.7374
1990's10 (15.38)18.2507
2000's21 (32.31)29.6817
2010's30 (46.15)24.3611
2020's3 (4.62)2.80

Authors

AuthorsStudies
Fantegrossi, WE; Wilson, CD; Zheng, F1
Nacca, N; Schult, R1
Bryant, SM; McCann, SD1
Daglioglu, N; Efeoglu Ozseker, P; Efeoglu, F; Gulmen, MK; Tolunay, I1
Aminirad, A; Fakhraei, N; Mousavi, SE; Mousavi, SM; Rezayat, SM1
Armenian, P; Brandehoff, NP; Clark, S; Darracq, M; Gevorkyan, J; Kaye, B1
Aghaei, I; Bahramnjead, E; Dehpour, AR; Etemadi, P; Kazemi Roodsari, S; Rahimi, N1
Gorodetsky, R; Kacinko, S; Krotulski, A; Loflin, R; Moran, J; Nacca, N; Schult, R; Weltler, A; Wiegand, T1
Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER1
Crane, J; Ewing, L; Fantegrossi, WE; Fujiwara, R; Lockhart, T; Radominska-Pandya, A; Tai, S; Wilson, CD1
Bahramnejad, E; Dehpour, AR; Faghir-Ghanesefat, H; Kazemi Roodsari, S; Keshavarz-Bahaghighat, H; Mokhtari, T; Rajai, N1
Aghaei, I; Bahramnejad, E; Dehpour, AR; Kazemi Roodsari, S; Rahimi, N1
Arslan, G; Gunes, H; Ozdemir, E1
Gerona, R; Hendrickson, RG; Rianprakaisang, T1
Kai, F; Nagata, M; Ozono, S; Sugiyama, T; Takayama, T1
Dastgheib, M; Moezi, L1
Arnold, JK; Edison, LA; Gerona, RR; Schwartz, MD; Steck, AR; Trecki, J1
Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H2
Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A1
Bai, Y; Chao, J; Dong, J; Shen, K; Yao, H; Zhu, X1
Amini-khoei, H; Amiri, S; Azizi, R; Dehpour, AR; Ghazi-Khansari, M; Haj-Mirzaian, A; Mehr, SE; Momeny, M; Rahimi-Balaei, M; Shirzadian, A; Zarrinrad, G1
Bailey, BC; Eustice, ER; Kacinko, S; Katz, KD; Leonetti, AL; Surmaitis, RM; Wheatley, SM1
Abouchedid, R; Archer, JR; Dargan, PI; Dines, A; Ho, JH; Hudson, S; Wood, DM1
Borea, PA; Canazza, I; De Luca, MA; Di Rosa, F; Fantinati, A; Gregori, A; Margiani, G; Marti, M; Ossato, A; Rimondo, C; Serpelloni, G; Trapella, C; Varani, K; Vincenzi, F1
Itoh, K; Watanabe, M1
Agar, E; Aslan, A; Ayyildiz, M; Güven, A; Yildirim, M1
Bahremand, A; Dehpour, AR; Hedayat, T; Nasrabady, SE; Payandemehr, B; Rahimian, R; Ziai, P1
Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P1
D'yakonova, VE; Krushinskii, AL; Kuzenkov, VS; Reutov, VP1
Dworzański, W; Jaskólska, A; Zółkowska, D; Łuszczki, JJ1
Djuric, D; Hrncić, D; Krstić, D; Macut, D; Rasić-Marković, A; Stanojlović, O; Susić, V1
Cai, ZY; Li, RP; Sun, XJ; Wang, ZZ; Xiao, K; Xiao, X; Xu, WG1
Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Sakamaki, K; Watabe, M1
Jayakumar, R; Rajasekaran, K; Venkatachalam, K1
Jovanovic, M; Radenovic, L; Selakovic, V; Vasiljevic, I1
COHEN, MP; SHAVEL, J; VONSTRANDTMANN, M1
Auker, CR; Chavko, M; McCarron, RM1
Ekambaram, P; Vanaja, P1
Ekambaram, P; Paul, V1
Rajasekaran, K1
Hagioka, S; Morita, K; Sato, T; Takeda, Y; Zhang, S1
Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N1
Czuczwar, K; Czuczwar, M; Czuczwar, SJ; Gawlik, P; Luszczki, JJ; Sawiniec-Pozniak, G1
Coelho, RC; Fighera, MR; Fiorenza, NG; Furian, AF; Mello, CF; Oliveira, MS; Petry, JC; Royes, LF1
Carletti, F; D'Agostino, S; Ferraro, G; La Grutta, V; Rizzo, V; Sardo, P1
Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T1
Akula, KK; Dhir, A; Kulkarni, SK1
Davis, W; Penix, LP; Subramaniam, S1
Busse, R; Mordvintcev, PI; Mülsch, A; Nielsen, EO; Olesen, SP; Scheel-Krüger, J; Vanin, AF1
De Vries, R; Dzoljic, MR; Van Leeuwen, R1
Carroll, DM; Grossman, AB; Kirkby, RD; Subramaniam, S1
Chapman, AG; Man, CM; Meldrum, BS; Smith, SE; Tang, E; Yip, PK1
Eblen, F; Klockgether, T; Löschmann, PA; Turski, L; Wüllner, U1
Baran, L; Przegaliñski, E; Siwanowicz, J1
Erden, BF; Kayaalp, SO; Tapanyigit, EE; Uzbay, IT1
Bitterman, H; Bitterman, N1
Masukawa, T; Nakanishi, K; Natsuki, R1
Heavner, JE; Shi, B1
Borowicz, KK; Czuczwar, SJ; Kleinrok, Z1
Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J1
Chavko, M; Keyser, DO; Xing, G1
Che, Y; Han, PL; Lee, JK; Piao, CS1
Hoshika, A; Katoh, N; Matsuura, K; Miyajima, T; Ohyu, J; Takami, T; Takashima, S; Takei, Y1
Bagetta, G; Corasaniti, MT; Del Duca, C; Leta, A; Nisticò, R; Paoletti, AM; Rotiroti, D1

Reviews

1 review(s) available for indazoles and Seizures

ArticleYear
Intoxication from the novel synthetic cannabinoids AB-PINACA and ADB-PINACA: A case series and review of the literature.
    Neuropharmacology, 2018, 05-15, Volume: 134, Issue:Pt A

    Topics: Adult; Aggression; Delirium; Designer Drugs; Electroencephalography; Humans; Indazoles; Male; Molecular Structure; Seizures; Tandem Mass Spectrometry; Valine

2018

Other Studies

64 other study(ies) available for indazoles and Seizures

ArticleYear
Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice.
    Psychopharmacology, 2022, Volume: 239, Issue:10

    Topics: Animals; Benzodiazepines; Cannabinoid Receptor Agonists; Cannabinoids; Convulsants; Diazepam; Electroencephalography; Humans; Indazoles; Indoles; Male; Mice; Naphthalenes; Pentylenetetrazole; Receptor, Cannabinoid, CB1; Rimonabant; Seizures; Substance-Related Disorders; Valine

2022
Nacca et al. In Reply to McCann et al.
    The Journal of emergency medicine, 2019, Volume: 57, Issue:3

    Topics: Atrioventricular Block; Coma; Humans; Hypoglycemia; Indazoles; Seizures

2019
ADB-FUBINACA Body Packer.
    The Journal of emergency medicine, 2019, Volume: 57, Issue:3

    Topics: Atrioventricular Block; Body Packing; Coma; Humans; Hypoglycemia; Indazoles; Seizures

2019
Determination of AB-FUBINACA and 5F-NPB-22 in rats exposed to "Bonsai" via inhalation and analysis of seized product.
    Legal medicine (Tokyo, Japan), 2021, Volume: 50

    Topics: Animals; Illicit Drugs; Indazoles; Inhalation; Nitrobenzenes; Rats; Seizures

2021
The role of nitric oxide in anticonvulsant effect of nanocurcumine on pentylenetetrazole-induced seizure in mice.
    Neuroscience letters, 2017, 06-09, Volume: 651

    Topics: Animals; Anticonvulsants; Convulsants; Curcumin; Dose-Response Relationship, Drug; Indazoles; Male; Mice; Nanoparticles; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Seizures

2017
Effects of Modafinil on Clonic Seizure Threshold Induced by Pentylenetetrazole in Mice: Involvement of Glutamate, Nitric oxide, GABA, and Serotonin Pathways.
    Neurochemical research, 2018, Volume: 43, Issue:11

    Topics: Animals; Anticonvulsants; Enzyme Inhibitors; Glutamic Acid; Indazoles; Male; Mice; Modafinil; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pentylenetetrazole; Seizures; Serotonin

2018
Coma, Seizures, Atrioventricular Block, and Hypoglycemia in an ADB-FUBINACA Body-Packer.
    The Journal of emergency medicine, 2018, Volume: 55, Issue:6

    Topics: Adult; Atrioventricular Block; Body Packing; Cannabinoids; Coma; Drug Trafficking; Foreign Bodies; Humans; Hypoglycemia; Illicit Drugs; Indazoles; Male; Seizures

2018
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
    The Journal of toxicological sciences, 2018, Volume: 43, Issue:11

    Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Combination; Ibuprofen; Indazoles; Male; Mice, Inbred Strains; Neurotoxins; Nitric Oxide; Pentylenetetrazole; Pilocarpine; Seizures; Thalidomide

2018
Convulsant Effects of Abused Synthetic Cannabinoids JWH-018 and 5F-AB-PINACA Are Mediated by Agonist Actions at CB1 Receptors in Mice.
    The Journal of pharmacology and experimental therapeutics, 2019, Volume: 368, Issue:2

    Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Humans; Illicit Drugs; Indazoles; Indoles; Male; Mice; Microsomes, Liver; Naphthalenes; Receptor, Cannabinoid, CB1; Seizures; Valine

2019
The Possible Role of Nitric Oxide Pathway in Pentylenetetrazole Preconditioning Against Seizure in Mice.
    Journal of molecular neuroscience : MN, 2019, Volume: 67, Issue:3

    Topics: Animals; Brain; Enzyme Inhibitors; GABA Antagonists; Guanidines; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Seizures; Signal Transduction

2019
Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.
    Annals of the New York Academy of Sciences, 2019, Volume: 1449, Issue:1

    Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Guanidines; Indazoles; Ketamine; Male; Methadone; Mice; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Seizures

2019
Coenzyme Q10 increases absence seizures in WAG/Rij rats: The role of the nitric oxide pathway.
    Epilepsy research, 2019, Volume: 154

    Topics: Action Potentials; Animals; Arginine; Dose-Response Relationship, Drug; Electrocorticography; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Transgenic; Seizures; Signal Transduction; Ubiquinone

2019
Commercial cannabidiol oil contaminated with the synthetic cannabinoid AB-FUBINACA given to a pediatric patient.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:3

    Topics: Cannabidiol; Child; Humans; Indazoles; Male; Plant Oils; Seizures

2020
Axitinib controlled metastatic renal cell carcinoma for 5 years.
    Japanese journal of clinical oncology, 2013, Volume: 43, Issue:7

    Topics: Aged; Antineoplastic Agents; Asian People; Axitinib; Brain Neoplasms; Carcinoma, Renal Cell; Disease-Free Survival; Humans; Imidazoles; Indazoles; Kidney Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Protein Kinase Inhibitors; Seizures; Tomography, X-Ray Computed; Treatment Outcome

2013
Acute and chronic effects of agomelatine on intravenous penthylenetetrazol-induced seizure in mice and the probable role of nitric oxide.
    European journal of pharmacology, 2014, Aug-05, Volume: 736

    Topics: Acetamides; Administration, Intravenous; Animals; Anticonvulsants; Convulsants; Guanidines; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Psychomotor Performance; Rotarod Performance Test; Seizures

2014
A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA.
    The Journal of emergency medicine, 2015, Volume: 48, Issue:5

    Topics: Acidosis; Adolescent; Adult; Aggression; Anxiety; Cannabinoids; Delirium; Disease Outbreaks; Female; Georgia; Humans; Hyperglycemia; Hypokalemia; Indazoles; Male; Middle Aged; Nausea; Seizures; Tachycardia; Vomiting; Young Adult

2015
The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide.
    Pharmacology, 2015, Volume: 95, Issue:5-6

    Topics: Animals; Anticonvulsants; Arginine; Aripiprazole; Convulsants; Electroshock; Guanidines; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Seizures

2015
The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide.
    Epilepsy & behavior : E&B, 2015, Volume: 48

    Topics: Animals; Anticonvulsants; Antipsychotic Agents; Arginine; Aripiprazole; Convulsants; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Guanidines; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pentylenetetrazole; Seizures

2015
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
    Brain research bulletin, 2016, Volume: 121

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Hippocampus; Indazoles; Male; Mice; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pentylenetetrazole; Seizures; Signal Transduction; Time Factors

2016
Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis.
    Brain research bulletin, 2016, Volume: 121

    Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Enzyme Inhibitors; Gene Expression Regulation; Hippocampus; Indazoles; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; RNA, Messenger; Seizures; SOXB1 Transcription Factors; Statistics, Nonparametric; Time Factors

2016
NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice.
    Brain research bulletin, 2016, Volume: 121

    Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immobility Response, Tonic; Indazoles; Ketamine; Male; Maze Learning; Mice; Motivation; NG-Nitroarginine Methyl Ester; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Social Isolation; Statistics, Nonparametric; Swimming; Time Factors

2016
Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center.
    The western journal of emergency medicine, 2016, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Cannabinoid Receptor Agonists; Cannabinoids; Female; Fever; Humans; Illicit Drugs; Indazoles; Male; Middle Aged; Practice Guidelines as Topic; Product Packaging; Public Health; Seizures; Substance-Related Disorders; Young Adult

2016
Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:4

    Topics: Adamantane; Administration, Intravenous; Anti-Anxiety Agents; Cannabinoid Receptor Agonists; Citalopram; Female; Fluoxetine; Hallucinations; Hallucinogens; Humans; Indazoles; Indoles; Lysergic Acid Diethylamide; Midazolam; Psychomotor Agitation; Quinolines; Seizures; Tachycardia; Time Factors; Young Adult

2016
Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on "tetrad", sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies.
    Psychopharmacology, 2016, Volume: 233, Issue:21-22

    Topics: Adamantane; Aggression; Animals; Behavior, Animal; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabis; Catalepsy; Dopamine; Dronabinol; Humans; In Vitro Techniques; Indazoles; Indoles; Male; Mice; Motor Activity; Naphthalenes; Nucleus Accumbens; Pain Threshold; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Abnormal; Seizures

2016
Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase.
    Neuroscience, 2009, Mar-17, Volume: 159, Issue:2

    Topics: Animals; Convulsants; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gene Expression Regulation; Imidazoles; Indazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Quinoxalines; Seizures

2009
Interaction of leptin and nitric oxide pathway on penicillin-induced epileptiform activity in rats.
    Brain research, 2010, Mar-19, Volume: 1321

    Topics: Animals; Anticonvulsants; Arginine; Brain; Convulsants; Electroencephalography; Enzyme Inhibitors; Indazoles; Leptin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penicillins; Rats; Rats, Wistar; Seizures; Signal Transduction

2010
Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice.
    Epilepsy research, 2010, Volume: 89, Issue:2-3

    Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indazoles; Injections, Intraperitoneal; Lithium Chloride; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Phosphodiesterase Inhibitors; Piperazines; Purines; Seizures; Sildenafil Citrate; Sulfones; Treatment Outcome

2010
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
    Epilepsy & behavior : E&B, 2010, Volume: 18, Issue:3

    Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Indazoles; Lithium Chloride; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Seizures; Signal Transduction

2010
Effect of inhibitors of inducible and neuronal NO synthases on the development of audiogenic stress-induced damage in Krushinskii-Molodkina rats.
    Bulletin of experimental biology and medicine, 2010, Volume: 150, Issue:1

    Topics: Animals; Enzyme Inhibitors; Guanidines; Indazoles; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Rats; Seizures; Shock, Hemorrhagic; Stress, Physiological

2010
7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:1

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Electroshock; Enzyme Inhibitors; gamma-Aminobutyric Acid; Indazoles; Male; Mice; Neuroprotective Agents; Nitroarginine; Pregabalin; Seizures; Toxicity Tests, Acute

2011
Inhibition of the neuronal nitric oxide synthase potentiates homocysteine thiolactone-induced seizures in adult rats.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2012, Volume: 8, Issue:1

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homocysteine; Indazoles; Male; Neurons; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Seizures

2012
Cerebral blood flow increase during prolonged hyperbaric oxygen exposure may not be necessary for subsequent convulsion.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:11

    Topics: Animals; Blood Flow Velocity; Cerebrovascular Circulation; Electroencephalography; Hyperbaric Oxygenation; Indazoles; Male; Rats; Rats, Sprague-Dawley; Seizures; Time Factors

2012
Anticonvulsant action of indazole.
    Epilepsy research, 2013, Volume: 104, Issue:3

    Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Indazoles; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures; Strychnine

2013
Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs.
    Brain research, 2003, Jul-25, Volume: 979, Issue:1-2

    Topics: Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Picrotoxin; Rats; Rats, Wistar; Seizures

2003
7-nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2003, Volume: 135, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Indazoles; Kainic Acid; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrites; Rats; Rats, Wistar; Seizures; Time Factors

2003
ACYLTRYPTAMINES. II. SYNTHESIS OF ACYLTRYPTAMINES, INDAZOLES, AND AZEPINOINDOLES FROM THE ACYLPHENYLHYDRAZONES OF 2,3-PIPERIDINEDIONE.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Antihypertensive Agents; Blood Pressure; Chemistry, Pharmaceutical; Dogs; Heterocyclic Compounds; Indazoles; Indoles; Mice; Pharmacology; Piperidines; Research; Seizures; Selective Serotonin Reuptake Inhibitors; Serotonin; Toxicology; Tryptamines

1963
Relationship between protein nitration and oxidation and development of hyperoxic seizures.
    Nitric oxide : biology and chemistry, 2003, Volume: 9, Issue:1

    Topics: Animals; Brain; Brain Chemistry; Electroencephalography; Enzyme Inhibitors; Hyperbaric Oxygenation; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Proteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Seizures; Superoxide Dismutase; Time Factors; Tyrosine

2003
Demonstrating the dose- and time-related effects of 7-nitroindazole on picrotoxin-induced convulsions, memory formation, brain nitric oxide synthase activity, and nitric oxide concentration in rats.
    Pharmacology, biochemistry, and behavior, 2004, Volume: 77, Issue:1

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Indazoles; Male; Memory; Nitric Oxide; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Wistar; Seizures; Time Factors

2004
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
    Indian journal of physiology and pharmacology, 2003, Volume: 47, Issue:4

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indazoles; Male; Phenobarbital; Picrotoxin; Rats; Rats, Wistar; Seizures

2003
Seizure-induced oxidative stress in rat brain regions: blockade by nNOS inhibition.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 80, Issue:2

    Topics: Animals; Brain; Enzyme Inhibitors; Indazoles; Male; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidative Stress; Rats; Rats, Wistar; Seizures

2005
Effects of 7-nitroindazole and N-nitro-l-arginine methyl ester on changes in cerebral blood flow and nitric oxide production preceding development of hyperbaric oxygen-induced seizures in rats.
    Neuroscience letters, 2005, Jul-15, Volume: 382, Issue:3

    Topics: Animals; Brain; Cerebrovascular Circulation; Electroencephalography; Enzyme Inhibitors; Indazoles; Laser-Doppler Flowmetry; Male; Microdialysis; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Rats; Seizures

2005
Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice.
    Epilepsy research, 2006, Volume: 68, Issue:2

    Topics: Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; Indazoles; Injections, Intraperitoneal; Kindling, Neurologic; Male; Melatonin; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Pentylenetetrazole; Seizures

2006
7-Nitroindazole potentiates the anticonvulsant action of some second-generation antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
    Journal of neural transmission (Vienna, Austria : 1996), 2006, Volume: 113, Issue:9

    Topics: Animals; Anticonvulsants; Avoidance Learning; Drug Synergism; Electroshock; Enzyme Inhibitors; Indazoles; Male; Memory; Mice; Neuroprotective Agents; Nitric Oxide Synthase Type I; Psychomotor Performance; Seizures

2006
The role of nitric oxide on the convulsive behavior and oxidative stress induced by methylmalonate: an electroencephalographic and neurochemical study.
    Epilepsy research, 2007, Volume: 73, Issue:3

    Topics: Animals; Anticonvulsants; Arginine; Corpus Striatum; Dose-Response Relationship, Drug; Electroencephalography; Indazoles; Male; Methylmalonic Acid; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Premedication; Rats; Rats, Wistar; Seizures; Sodium-Potassium-Exchanging ATPase

2007
Lamotrigine differently modulates 7-nitroindazole and L-arginine influence on rat maximal dentate gyrus activation.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:1

    Topics: Animals; Anticonvulsants; Arginine; Dentate Gyrus; Electric Stimulation; Enzyme Inhibitors; Indazoles; Lamotrigine; Male; Nitric Oxide; Rats; Rats, Wistar; Seizures; Triazines

2008
Activities of 7-nitroindazole and 1-(2-(trifluoromethylphenyl)-imidazole independent of neuronal nitric-oxide synthase inhibition.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:2

    Topics: Aminobutyrates; Animals; Anticonvulsants; Brain; Herbicides; Imidazoles; Indazoles; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Seizures

2008
Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol-induced seizure threshold in mice.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Adenosine; Animals; Anticonvulsants; Arginine; Convulsants; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Guanidines; Indazoles; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroprusside; Pentylenetetrazole; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Seizures; Signal Transduction; Sildenafil Citrate; Sulfones

2008
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents.
    Epilepsy research, 1994, Volume: 18, Issue:3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bicuculline; Cerebrovascular Circulation; Enzyme Inhibitors; Indazoles; Kainic Acid; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures

1994
Nitric oxide promotes seizure activity in kainate-treated rats.
    Neuroreport, 1994, Nov-21, Volume: 5, Issue:17

    Topics: Amino Acid Oxidoreductases; Animals; Diazepam; Ditiocarb; Indazoles; Iron; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Seizures

1994
7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures.
    European journal of pharmacology, 1995, Dec-12, Volume: 287, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Nitric Oxide Synthase; Pilocarpine; Seizures

1995
Factors determining proconvulsant and anticonvulsant effects of inhibitors of nitric oxide synthase in rodents.
    Epilepsy research, 1996, Volume: 24, Issue:2

    Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Kainic Acid; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Picrotoxin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures; Species Specificity

1996
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.
    British journal of pharmacology, 1996, Volume: 119, Issue:1

    Topics: Animals; Anticonvulsants; Arginine; Blood Pressure; Citrulline; Disease Models, Animal; Epilepsy; Female; Heart Rate; Indazoles; Male; Mice; Mice, Inbred DBA; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Noise; Rats; Rats, Inbred Strains; Reflex; Seizures

1996
Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions.
    European journal of pharmacology, 1996, Mar-28, Volume: 299, Issue:1-3

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Harmaline; Hydroxydopamines; Indazoles; Lisuride; Locomotion; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroarginine; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Seizures

1996
The role of nitric oxide in chemically- and electrically-induced seizures in mice.
    Neuroscience letters, 1996, Oct-18, Volume: 217, Issue:2-3

    Topics: Animals; Convulsants; Electroshock; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Male; Mice; Muscarinic Agonists; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Pilocarpine; Seizures

1996
Nitric oxide synthase inhibition attenuates signs of ethanol withdrawal in rats.
    Life sciences, 1997, Volume: 61, Issue:22

    Topics: Acoustic Stimulation; Alcoholism; Animals; Arginine; Behavior, Animal; Enzyme Inhibitors; Ethanol; Indazoles; Male; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome

1997
L-arginine-NO pathway and CNS oxygen toxicity.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 84, Issue:5

    Topics: Animals; Arginine; Central Nervous System; Electroencephalography; Enzyme Inhibitors; Hyperoxia; Indazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Penicillamine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Seizures

1998
Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.
    Japanese journal of pharmacology, 1998, Volume: 76, Issue:4

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Enoxacin; Enzyme Inhibitors; Indazoles; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phenylbutyrates; Seizures

1998
Nitric oxide modulation affects the tissue distribution and toxicity of bupivacaine.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:3

    Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Drug Interactions; Enzyme Inhibitors; Female; Heart; Hemodynamics; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Seizures; Tissue Distribution

2000
7-nitroindazole differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats.
    Epilepsia, 2000, Volume: 41, Issue:9

    Topics: Amygdala; Animals; Anticonvulsants; Brain; Electroshock; Enzyme Inhibitors; Escape Reaction; Indazoles; Kindling, Neurologic; Motor Activity; Nitric Oxide Synthase; Rats; Rats, Wistar; Seizures

2000
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:10

    Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; Epilepsies, Myoclonic; Ethosuximide; Indazoles; Male; Mice; Motor Skills; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Seizures

2000
Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation.
    Brain research, 2001, May-11, Volume: 900, Issue:2

    Topics: Animals; Calcium; Cerebral Cortex; Electroencephalography; Enzyme Activation; Enzyme Inhibitors; Hyperbaric Oxygenation; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Reaction Time; Reference Values; Seizures; Time Factors

2001
Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain.
    Journal of neuroscience research, 2001, Sep-01, Volume: 65, Issue:5

    Topics: Animals; Arginine; Astrocytes; Crystallins; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Gliosis; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Indazoles; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Molecular Chaperones; Neoplasm Proteins; Nerve Degeneration; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Seizures

2001
Different effects between 7-nitroindazole and L-NAME on cerebral hemodynamics and hippocampal lesions during kainic acid-induced seizures in newborn rabbits.
    Brain & development, 2001, Volume: 23, Issue:6

    Topics: Animals; Animals, Newborn; Brain Chemistry; Cerebrovascular Circulation; Electroencephalography; Enzyme Inhibitors; Female; Hippocampus; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen Consumption; Pregnancy; Rabbits; Seizures; Spectroscopy, Near-Infrared

2001
Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat.
    Biochemical and biophysical research communications, 2002, Feb-22, Volume: 291, Issue:2

    Topics: Animals; Blotting, Western; Cholinesterase Inhibitors; Enzyme Inhibitors; Hippocampus; Indazoles; Lithium Chloride; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Seizures; Tacrine

2002