indazoles and Neuroblastoma

Topics: Anaplastic Lymphoma Kinase; Animals; Benzamides; Humans; Indazoles; Neuroblastoma; Protein Kinase Inhibitors; Receptor Protein-Tyrosine Kinases

Topics: Anaplastic Lymphoma Kinase; Benzamides; Chromosomes, Human, Pair 2; Cytokines; Genetic Variation; Germ Cells; Humans; Indazoles; Infant; Male; Neuroblastoma; Protein Kinase Inhibitors; Receptor, trkA

Topics: Aminopyridines; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Survival; Diphenylamine; Humans; Indazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neuroblastoma; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Pyrazoles; Pyridones; Pyrimidines; Pyrroles

Topics: Alternative Splicing; Benzamides; Calmodulin; Cell Line, Tumor; Crizotinib; Doxorubicin; Humans; Indazoles; Neuroblastoma; Oxygen; Proto-Oncogene Proteins c-akt; Receptor, trkA; Ryanodine Receptor Calcium Release Channel

Topics: Humans; Hydrogen Peroxide; Indazoles; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotection; Oxadiazoles; Structure-Activity Relationship

Topics: Animals; Apoptosis; Benzamides; Biomarkers, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Mice, Nude; Neuroblastoma; Protein Kinase Inhibitors; Proteome; RNA-Seq; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Topics: Animals; Cannabinoid Receptor Agonists; Cell Differentiation; Cell Survival; Glioma; Indazoles; Indoles; Mice; Mitochondria; Naphthalenes; Neuroblastoma; Quinolines; Rats; Receptor, Cannabinoid, CB1; Tumor Cells, Cultured

Topics: Antiparkinson Agents; Bromides; Coordination Complexes; Humans; Indazoles; Metals; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroblastoma; Neuroprotective Agents; Protein Binding; Small Molecule Libraries; Structure-Activity Relationship; Tyramine

Topics: Animals; Astrocytes; Calcium-Binding Proteins; Cell Line, Tumor; Cognition; Collagen Type IV; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glial Fibrillary Acidic Protein; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Motor Activity; Mutation; Neuroblastoma; Phosphorylation; Pyrimidines; Receptors, Vascular Endothelial Growth Factor; RNA, Small Interfering; Silver Staining; Sulfonamides; tau Proteins; Tauopathies; Transfection; Treatment Outcome

Topics: Animals; Azepines; Cell Line, Tumor; Disease-Free Survival; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Humans; Indazoles; Mice, Nude; Molecular Targeted Therapy; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteins; Signal Transduction; Sulfonamides; Triazoles; Xenograft Model Antitumor Assays

Topics: Animals; Caspase 3; Cell Line, Tumor; Chemoradiotherapy; Enzyme Inhibitors; Female; Histones; Humans; Indazoles; Mice; Neoplasm Metastasis; Neuroblastoma; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Radiation-Sensitizing Agents

Topics: Anaplastic Lymphoma Kinase; Apoptosis; Autophagy; Benzamides; Blotting, Western; Cell Cycle; Cell Movement; Cell Proliferation; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Indazoles; Neuroblastoma; Phosphorylation; Real-Time Polymerase Chain Reaction; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Wound Healing

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Camptothecin; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship, Drug; Humans; Indazoles; Irinotecan; Membrane Glycoproteins; Mice, Nude; Neuroblastoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Receptor, trkB; Signal Transduction; Temozolomide; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Antineoplastic Agents; Dimethyl Sulfoxide; Humans; Hypoxia; Indazoles; Neuroblastoma; Organometallic Compounds; Ruthenium; Ruthenium Compounds; Spheroids, Cellular; Tumor Cells, Cultured; Tumor Microenvironment; X-Ray Absorption Spectroscopy

Topics: Anilides; Animals; Apoptosis; Axitinib; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Hepatocyte Growth Factor; Humans; Imidazoles; Indazoles; Mice; Neoplasm Invasiveness; Neuroblastoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Xenograft Model Antitumor Assays

Topics: Apoptosis Regulatory Proteins; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; DNA Damage; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation, Neoplastic; Herbicides; Humans; Indazoles; NADPH Dehydrogenase; Neuroblastoma; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nuclear Proteins; Paraquat; Peroxynitrous Acid; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53

Topics: Animals; Apoptosis; Axitinib; Blotting, Western; Bone Marrow Neoplasms; Child; Drug Synergism; Endothelium, Vascular; Humans; Imidazoles; Indazoles; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Neuroblastoma; Phosphorylation; Sirolimus; Stem Cells; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2; Vascular Endothelial Growth Factor Receptor-3; Xenograft Model Antitumor Assays

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amidines; Animals; Asparagine; Caspase 3; Cell Death; Cell Line, Tumor; Citrulline; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indazoles; L-Lactate Dehydrogenase; Leupeptins; Mice; Neuroblastoma; Neurotoxins; Nitric Oxide Synthase Type I; Thiophenes; Transfection; Tritium; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins

Topics: Administration, Metronomic; Administration, Oral; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cell Line, Tumor; Endothelial Cells; Humans; Indazoles; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels; Neoplasms; Neoplastic Cells, Circulating; Neovascularization, Pathologic; Neuroblastoma; Osteosarcoma; Pyrimidines; Random Allocation; Rhabdomyosarcoma; Stem Cells; Sulfonamides; Topoisomerase I Inhibitors; Topotecan; Xenograft Model Antitumor Assays

Topics: 3' Untranslated Regions; Animals; Apoptosis; Binding Sites; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glucose; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Mice; MicroRNAs; Neuroblastoma; Neurons; Oxygen; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Messenger; Time Factors; Transfection

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Hepatocellular; Cell Hypoxia; Culture Media, Conditioned; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Female; G(M1) Ganglioside; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Indazoles; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Killer Cells, Natural; Liver Neoplasms; Lymphokines; Male; Mice; Mice, SCID; Neoplasms; Neovascularization, Pathologic; Neuroblastoma; Platelet Endothelial Cell Adhesion Molecule-1; Precipitin Tests; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Transcription Factors; Transplantation, Heterologous; Tumor Cells, Cultured; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cisplatin; Down-Regulation; Drug Resistance, Neoplasm; Etoposide; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; Vincristine

Topics: Acetylation; Cell Line, Tumor; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Drug Interactions; Exons; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Indazoles; Luciferases; Neuroblastoma; NF-kappa B; Nitric Oxide Synthase Type I; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transfection

Topics: Animals; Benzamides; Biguanides; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Glioma; Granisetron; Indazoles; Kinetics; Neuroblastoma; Ondansetron; Quipazine; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium

Topics: Anti-Anxiety Agents; Benzamides; Benzofurans; Biguanides; Bridged Bicyclo Compounds, Heterocyclic; Humans; Hypoglycemic Agents; Indazoles; Indoles; Neuroblastoma; Neurotoxins; Ondansetron; Potassium Channels; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Rubidium Radioisotopes; Serotonin Antagonists; Serotonin Receptor Agonists; Structure-Activity Relationship; Tropanes; Tropisetron; Tumor Cells, Cultured

Topics: Calcimycin; Calcineurin Inhibitors; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Death; Indazoles; Ionophores; Neuroblastoma; Sulfonamides; Tumor Cells, Cultured

Topics: Analysis of Variance; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Extracts; Enzyme Inhibitors; Hippocampus; Indazoles; Neuroblastoma; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Sulfonamides; Tumor Cells, Cultured

Topics: Animals; Azepines; Glioma; Hybrid Cells; In Vitro Techniques; Indazoles; Male; Neuroblastoma; Rats; Rats, Inbred Strains; Serotonin Antagonists; Stereoisomerism; Tubocurarine; Tumor Cells, Cultured; Vagus Nerve