Page last updated: 2024-08-21

indazoles and Disease Models, Animal

indazoles has been researched along with Disease Models, Animal in 245 studies

Research

Studies (245)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (0.82)	18.7374
1990's	14 (5.71)	18.2507
2000's	62 (25.31)	29.6817
2010's	144 (58.78)	24.3611
2020's	23 (9.39)	2.80

Authors

Authors	Studies
Bomsztyk, K; Goryca, K; Kopczynski, M; Kulecka, M; Majewska, E; Masiejczyk, M; Mikula, M; Ostrowski, J; Pysniak, K; Pyziak, K; Rumienczyk, I; Rzymski, T; Sandowska-Markiewicz, Z; Statkiewicz, M; Wojcik-Jaszczynska, K; Wojcik-Trechcinska, U	1
Liu, M; Liu, T; Sun, L; Tan, S; Tang, J; Xiao, W; Zhou, X	1
Chen, J; He, P; Tian, M; Yu, R; Zhang, B; Zhang, Y; Zhao, Z	1
Fitch, WL; Gajera, CR; Lam, G; Leśniak, RK; Montine, TJ; Nguyen, KC; Nichols, RJ; Schonemann, M; Smith, M; Zhao, J	1
Berta, T; Brown, FN; Campbell, K; Goto, J; Iwasawa, E; Kahn, F; Ladle, DR; Lee, SH; Mangano, FT; Shula, C	1
Chen, D; Chen, Y; Du, G; Fang, L; Niu, Z; Yuan, T; Zhang, H	1
Cai, C; Kilari, S; Misra, S; Singh, AK	1
Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H	1
Chao, W; Gu, CJ; Hadas, E; Kelschenbach, J; Kim, BH; Potash, MJ; Volsky, DJ	1
Abdel-Haq, M; Amal, H; Domb, AJ; Hamoudi, W; Khaliulin, I; Kumar, A; Ojha, SK; Tripathi, MK	1
Bianchetti, E; Canoll, P; Ishida, CT; Karpel-Massler, G; Kleiner, G; Nguyen, TTT; Quinzii, CM; Sanchez-Quintero, MJ; Shang, E; Shu, C; Siegelin, MD; Torrini, C; Westhoff, MA; Zhang, Y	1
Dimmito, MP; Dvorácskó, S; Minosi, P; Mollica, A; Pieretti, S; Stefanucci, A; Tömböly, C; Zengin, G	1
Li, C; Lu, F; Yan, JZ; Yang, Q; Yin, XH; Yu, LM; Zhang, TY	1
Fillo, S; Lista, F; Mattarei, A; Megighian, A; Montecucco, C; Negro, S; Pirazzini, M; Rigoni, M; Zanetti, G	1
Haniuda, H; Horita, S; Kagawa, Y; Katagiri, M; Nakamura, H; Nakazato, T; Watanabe, M	1
Balis, P; Berenyiova, A; Cacanyiova, S; Dovinova, I; Kvandova, M; Majzunova, M	1
Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R	1
Choo, H; Gu, SJ; Jang, K; Jo, S; Jung, JU; Kim, JS; Kim, S; Kim, TH; Kim, YR; Lee, D; Min, SJ; Yang, CS; Young Kim, S	1
Eckmann, L; Fokin, VV; Ghassemian, M; Ihara, S; Kalisiak, J; Korthals, KA; Lauwaet, T; Le, C; Miyamoto, Y; Sharpless, KB; Smith, DK	1
Huang, X; Li, H; Li, L; Lou, W; Zhu, Y	1
Chen, L; Cheng, S; Li, B; Lin, Z; Wang, M; Wang, W; Yao, M; Yin, Q; Zhang, Y	1
Appleyard, CB; Flores, I; Luna, N; Seguinot-Tarafa, I; Suarez, E	1
Aasen, T; Abdul Moin, NI; Abdul Wafi, S; Aboukameel, A; Abu-Bakar, N; Acharya, A; Ackermans, L; Adaramoye, O; Adarsh, KV; Adeosun, WA; Ahmad, NH; Ahmadi, F; Akanni, O; Akbar, M; Akbulak, RO; Akev, N; Akkaya, Ö; Al-Rashed, S; AlAbbad, S; Alabi, O; Alappat, BJ; Alcalá, S; Alcoutlabi, M; Aleppo, G; Alexander Ross, JB; Alexander, JH; Alexander, R; Alias, A; Alimba, C; Alken, FA; Allan, R; Alpers, M; Alsbou, EM; Amarasiri, SS; An, T; Anastasiadis, F; Anastassiadou, M; Anderson, KC; Andronikos, P; Anheyer, D; Annapurna, K; Anorlu, RI; Anten, MM; Anthopoulos, TD; Araujo-Castillo, RV; Aravamudhan, S; Arawwawala, LDAM; Arulsamy, N; Arunamata, A; Asghar, A; Asiri, AM; Aslanidou, T; Astrakhantseva, IV; Astutik, E; Attanayake, AP; Atwater, BD; Audureau, E; Augusto, S; Bakare, A; Banach, M; Bandelier, P; Banerjee, S; Barral, M; Bascuñán, J; Bates, FS; Bauer, NJC; Bayrak, BB; Beck, RW; Beckervordersantforth, J; Beeri, R; Begum, R; Beldi-Ferchiou, A; Bellingham, G; Ben-Tal, N; Bendib, I; Bergenstal, RM; Berger, MF; Bernasconi, G; Berry, S; Beuvon, F; Bi, WJ; Bi, Z; Bianconi, V; Bibi, I; Blank, BR; Bliemeister, E; Bobkowski, W; Bode, AM; Booth, CM; Bose, U; Boyd, K; Brancato, A; Brenmoehl, J; Brogi, E; Bronzo, P; Brooks, T; Brown, D; Brown, DN; Bruce, D; Buan, MEM; Bueno-Hernández, F; Bugielski, B; Bulavaitė, A; Buscagan, TM; Buxton, R; Caffaro, MM; Cai, Q; Cai, X; Cai, Y; Calhoun, P; Callander, N; Cambier, S; Camparo, P; Canales-Vargas, EJ; Canham, K; Cantu, J; Cao, J; Cao, JW; Cao, P; Cao, T; Cao, X; Caravella, BA; Carcadea, E; Carè, J; Carmichael, P; Carrasco Cabrera, L; Carteaux, G; Carvalho, PDS; Casarez, E; Cazorla, M; Celestrin, CP; Chakraborty, NK; Chan, B; Chandarlapaty, S; Chandgude, AL; Chang, CC; Chang, JH; Chang, X; Chang, Y; Chankhanittha, T; Chantanis, S; Chapovetsky, A; Chavan, S; Chen, B; Chen, D; Chen, F; Chen, G; Chen, H; Chen, J; Chen, K; Chen, KJ; Chen, KP; Chen, L; Chen, MA; Chen, Q; Chen, S; Chen, W; Chen, WF; Chen, X; Chen, Y; Cheng, D; Cheng, J; Cheng, Q; Cheon, GJ; Chiu, SC; Cho, CH; Cho, J; Choi, H; Choi, JS; Choi, YH; Christie, P; Chu, CH; Chu, Y; Chung, DH; Chung, F; Cline, JP; Cohen, A; Cohen, AD; Cohen, NJ; Comen, E; Compter, I; Cong, J; Cong, Z; Cooper, A; Cornud, F; Costa, C; Costa, S; Covey, A; Cowan, AM; Cramer, H; Cruz-Rivera, C; Cui, J; Cui, M; Cui, Y; Cui, YH; Culquichicón, C; Cushman, T; D'Auria, SJ; da Silva, J; Dalgediene, I; Danenberg, HD; Das, S; Dasgupta, K; Daubit, IM; de Oliveira, PD; de Prost, N; De Ruysscher, D; Dearman, K; Decato, D; Delfau-Larue, MH; Deng, L; Dhakate, SR; Dharuman, V; Di Costanzo, N; Dickler, MN; Dinehart, EE; Ding, D; Dinh, TK; Divya, KP; Djifack Tadongfack, T; Do, T; Domínguez-Roldan, R; Domínguez-Zambrano, E; Dömling, A; Donato, MD; Dong, JH; Dong, W; Dong, X; Dong, XR; Dong, Y; Dong, Z; Downs, M; Drutskaya, MS; Du, B; Du, F; Du, H; Du, L; Du, X; Duan, Z; Duangthip, D; Dunstand-Guzmán, E; Duong, F; Eckert, DJ; Edelhäuser, BAH; Eekers, DBP; Efendi, F; Efraimidis, P; Ehrenberg, H; Ehsanbakhsh, Z; Eickholt, C; Eksterowicz, J; El Mobadder, M; El-Araby, IE; El-Magd, MA; El-Tarabany, MS; Elgorban, AM; Engelmann, D; English, KL; Esfandiari, H; Eslami, B; Espinosa-Cuevas, A; Eswara, S; Faber, E; Fan, XH; Fan, Y; Fang, J; Fang, Z; Fantin, VR; Fei, P; Feng, G; Feng, H; Feng, J; Feng, X; Feng, XJ; Fennell, TR; Fernández-Moreira, V; Ferraz, ABF; Ferreras, KN; Flores, K; Flores-Pérez, I; Flox, C; Fluharty, FL; Fokouong Tchoffo, E; Folefack, GO; Foroutan, T; Fort, D; Fourati, S; Fousas, S; Frapard, T; Freguia, S; Friedman, DJ; Friedman, LS; Fu, D; Fu, Q; Fu, Y; Fujinami, S; Furihata, K; Gal, RL; Gan, H; Gao, C; Gao, F; Gao, R; Gao, SS; Gao, W; Gao, XC; Gao, Y; Gao, Z; Garozi, L; Ge, J; Georgiopoulos, A; Gerakiou, K; Ghazimirsaeed, SM; Ghazimirsaeed, ST; Gimeno, MC; Gjestad, R; Glurich, I; Goetchius, E; Goland, S; Goldstein, S; Gonçalves, CM; Gonçalves, H; Gong, Q; Gonzalez, D; Goplen, FK; Gorshkova, EN; Gotsman, I; Govindasamy, V; Granger, CB; Greco, L; Grigoriadou-Skouta, E; Grigoropoulos, P; Grivicich, I; Gromov, NV; Gruber, S; Grytczuk, M; Grzech-Leśniak, K; Gu, L; Gu, S; Gu, Z; Guadagnini, D; Guan, H; Guilliams, M; Guo, J; Guo, L; Gupta, A; Gupta, SK; Gurzu, S; Gutleb, AC; Haban, A; Hablitz, JJ; Hadisuyatmana, S; Hahn, S; Haiges, R; Hallal-Calleros, C; Hamed, M; Hammad, N; Hammer, N; Han, C; Hao, Y; Harnett, J; Has, EMM; Hassanpour, K; Hatzopoulos, D; Hawaldar, R; He, X; He, Y; He, YY; He, Z; Heberman, D; Heckl, D; Hegde, H; Henson, MA; Hernández-Velázquez, VM; Herrera, E; Hijazi, Z; Hirayama, K; Hirth, JM; Hoeben, A; Hohnloser, SH; Hong, M; Hood, K; Hoplock, LB; Hopman, WM; Horlbogen, LM; Hossein Rashidi, B; Hou, G; Hou, H; Hou, J; Hou, Y; Hu, J; Hu, W; Hu, X; Hua, W; Huang, G; Huang, H; Huang, J; Huang, T; Huang, W; Huang, Y; Huang, YD; Huang, Z; Hudis, CA; Hue, S; Huo, J; Hussain, M; Hvas, AM; Ichii, T; Ide Zeuna, J; Ilyas, S; Inoue, T; Iranzo, A; Irfan, M; Iwasa, Y; Iwashita, Y; Izgorodina, EI; J R, A; Jaber, WA; Jaborek, JR; Jacobus, SJ; Jadeja, SD; Jafarabadi, M; Jalan, D; Jamil, MI; Jarrah, S; Jarvis, D; Jayatilaka, KAPW; Jemal-Turki, A; Jeon, YK; Jeong, N; Jeong, SH; Jeong, SY; Jermy, M; Jhaveri, K; Ji, H; Ji, K; Ji, RY; Jiang, F; Jiang, J; Jiang, X; Jiang, Y; Jiao, Q; Jilani, K; Jiménez-Guerrero, P; Jin, L; Jo, YH; Johnson, JG; Johnson, ML; Jones, WS; Jose, S; Jularic, M; Jung, I; Jung, YJ; Jungen, C; Junttila, MR; Kache, S; Kahanovitch, U; Kalantzi, KI; Kallio, T; Kamnoedboon, P; Kang, CH; Kang, H; Kang, J; Kang, KW; Kapoor, P; Karmakar, D; Kartalis, A; Kauranen, P; Kazocina, A; Keikha, F; Keltai, M; Kershaw, SV; Kettani, M; Khalvati, S; Khandhar, S; Khosla, N; Kiely, CJ; Kim, CC; Kim, H; Kim, MJ; Kim, Y; Kim, YH; Kim, YT; Kimoto, E; Kiyu, A; Klatt, N; Kobayashi, M; Koh, J; Köhler, R; Kondadasula, SV; Kong, H; Kong, W; Kong, X; Kotidis, A; Kotwal, A; Kouvari, M; Kozhinov, AN; Kruger, D; Kuang, S; Kuang, Y; Kubota, M; Kuklik, P; Kumar, P; Kumar, SK; Kuo, YF; Kurup, SP; Kusuhara, H; Kuswanto, H; Lacouture, ME; Lambin, P; Lang, CC; Langroudi, FH; Lanman, RB; Larsen, OH; Laskin, J; Le, VH; Leach, M; Lee, BG; Lee, DF; Lee, DS; Lee, HJ; Lee, SB; Lee, YA; Lei, Y; Lekashvili, O; Lelj, F; Lemin, AS; Lemoine, J; Leuschner, R; Li, B; Li, BT; Li, C; Li, D; Li, F; Li, G; Li, H; Li, HW; Li, J; Li, M; Li, P; Li, Q; Li, S; Li, W; Li, X; Li, XY; Li, Y; Li, Z; Lian, Y; Liang, C; Liao, J; Liao, W; Liao, Y; Lin, D; Lin, W; Lin, YL; Lindbäck, J; Lindsay, AP; Ling, J; Linser, PJ; Liu, C; Liu, H; Liu, JJ; Liu, L; Liu, Q; Liu, SF; Liu, X; Liu, Y; Liu, Z; Liu, ZM; Lo Sterzo, C; Lo, ECM; Lobchuk, MM; Lodge, TP; Logotheti, S; Lonial, S; Lopes, G; Lopes, RD; Lopez, J; Lopez, SA; López-Santos, AL; López-Sendón, JL; Loring, Z; Louis, C; Lovita, AND; Lu, DZ; Lu, H; Lu, J; Lu, K; Lu, TT; Lu, Y; Luengo, A; Lum, LG; Luna, JM; Luo, L; Luo, R; Luo, T; Luo, X; Luo, Z; Lv, B; Lymperopoulos, N; Lyras, A; Lyu, Y; M Kannan, A; Ma, H; Ma, M; Ma, Q; Ma, S; Ma, WY; Ma, Y; Maalouf, E; Machado, FA; Maeda, K; Magrans, JO; Maharani, A; Maia, G; Mainwaring, RD; Maji, TK; Majumdar, K; Mannarino, MR; Mansuri, MS; Marinescu, SC; Markatos, G; Marquardt, S; Marraiki, N; Martens, C; Martínez, TJ; Marumo, K; Maruyama, H; Marwani, HM; Marzo, I; Masrati, G; Matamba, P; Mathialagan, S; Matys, J; Mayatra, JM; Mboua, PC; McArthur, T; McCrimmon, RJ; McIntosh, S; McSpadden, S; Medina-Campos, ON; Medvedovsky, AT; Mei, Z; Mekontso-Dessap, A; Menezes, AMB; Meng, J; Meng, P; Meng, Y; Menter, A; Mets, MB; Mets-Halgrimson, R; Metzger, T; Metzler-Nolte, N; Meyer, C; Mi, Y; Michailoviene, V; Mikrogeorgiou, A; Militz, H; Miller Iii, TF; Minarowska, A; Mir, S; Miron, I; Miyake, T; Moayer, F; Modi, S; Moeller, SJ; Mohamad, MN; Mohammed, EHM; Mokhonov, VV; Mondal, A; Moore, J; Moravcova, M; Mordi, IR; Mordi, NA; Mortensen, NP; Moscariello, C; Moser, J; Moynahan, ME; Mu, J; Mu, W; Mudduwa, LKB; Mukherjee, S; Mukhtar, A; Mulkey, DK; Murr, N; Mushtaq, Z; Muthuswamy, N; Mutlu, O; Muto, C; Myroforou, I; Na, KJ; Nabi, M; Nagornov, KO; Nagy, RJ; Naik, A; Nakajima, K; Nam, KT; Nam, YW; Namburath, M; Nammour, S; Namour, A; Namour, M; Nanan, S; Natsume, H; Nave, S; Naveed, A; Nazir, H; Ndubaku, C; Nedospasov, SA; Neradilek, MB; Newcomb, C; Nguépy Keubo, FR; Nguyen, M; Ning, J; Ning, Q; Noguchi, S; Nordahl, SHG; Nordfalk, KF; Norton, L; Noupoue, EM; Nouri, SS; Nowak, JK; Núñez, K; Oakes, K; Odegaard, JI; Ogorodnikova, OL; Ogunsuyi, O; Oh, HK; Oh, HR; Oh, KH; Ohgi, K; Okunade, KS; Oliveira, AG; Olorunfemi, G; Olsen, ML; Olson, BA; Omari, KW; Ondruschka, B; Orfali, R; Orkopoulos, A; Orlowski, RZ; Oser, SM; Oser, TK; Özcan, M; Padilla, V; Paeng, JC; Pajuelo-Lozano, N; Pal, SK; Palmieri, S; Palomeque, E; Pan, W; Panagiotakos, DB; Pandey, M; Pang, D; Pang, Q; Pangarah, CA; Panny, A; Paparella, A; Papirio, S; Papouskova, K; Parang, K; Park, HJ; Park, IK; Park, S; Parker, TL; Parkhomenko, A; Parmon, VN; Parsons, B; Parsons, J; Patel, PR; Patil, S; Patsourakos, NG; Patterson, KC; Pavlidis, P; Pedernera, M; Pedersen, R; Pedraza-Chaverri, J; Pellegrini, M; Peña-Chora, G; Pereira, EDM; Pereira, MADS; Peretz, A; Perez-Padilla, R; Perlman, GY; Perona, R; Petras, C; Phuntsho, S; Picada, JN; Pinder, TA; Piper, LFJ; Pirozzi, F; Pirro, M; Pleckaityte, M; Ploutz-Snyder, LL; Ploutz-Snyder, R; Pogorzelski, A; Poles, L; Postma, AA; Prager, A; Prakash, J; Punn, R; Pützer, BM; Qi, J; Qi, MC; Qi, Y; Qian, J; Qian, Y; Qiang, L; Qiu, J; Qu, Y; Rabiu, KA; Rahighi, S; Rahman, MM; Rahmani, B; Rajkumar, SV; Ramanathan, R; Raras, TYM; Rashi, Y; Rasool, G; Rathore, MG; Ratnawati, R; Ratola, N; Raucci, U; Ray, SK; Razavi, P; Razazi, K; Razek, S; Razi, SS; Reback, M; Reddy, K; Rees, DC; Reginatto, FH; Reich, H; Reis-Filho, JS; Ren, X; Ren, Y; Renner, G; Rey, G; Reymen, B; Riaz, M; Ricci, A; Richardson, PG; Richter, C; Riga, M; Ritchie, C; Rivoal, S; Roberts, W; Robson, ME; Rocha, GZ; Rodrigues, AD; Rogach, AL; Rojas, A; Rosenberg, A; Rosenberg, E; Rosenheck, RA; Roslan, K; Rothenberger, C; Rouschop, KMA; Rubagumya, F; Ryan, CM; Ryder, JW; Saad, MJA; Sacan, O; Sacchi, A; Sahebkar, A; Saini, A; Sainz, B; Sajo, EA; Sakizadeh, J; Saleh, AA; Salgado Júnior, IB; Salvi, R; Samoylova, YV; Samuni, A; Sanchez, DM; Sanchez-Perez, I; Santos, M; Sarapulova, A; Sardot, T; Saud, N; Sauerbier, P; Scaltriti, M; Schaeffer, B; Schalk, DL; Scherschel, K; Schijven, MP; Schreuder, HWR; Schuhmacher, M; Schultz-Lebahn, A; Schwarzl, J; Scott, JM; Sebayang, SK; Seeger, ZL; Segabinazi Peserico, C; Selenica, P; Serio, A; Seruga, B; Shah, A; Shah, C; Shah, PD; Shahrokh Tehraninezhad, E; Shan, A; Shao, Z; Sharma, AMR; Sharma, RK; Shen, J; Shen, R; Shi, X; Shi, Y; Shi, ZE; Shih, YC; Shimohata, H; Shimpi, N; Shin, SH; Shon, HK; Shuvy, M; Siddique, AB; Siegbahn, A; Sikandar, M; Silvani, Y; Singh, A; Singh, AK; Singh, D; Singh, JS; Singh, KP; Singh, M; Situ, B; Skipper, MT; Skouloudi, M; Sloane, BF; Smyrnioudis, N; Snyder, MA; Söhnchen, C; Solis Condor, R; Solit, DB; Someya, S; Song, H; Song, J; Song, W; Song, Y; Sorokina, KN; Soshi, S; Soyer, P; Spitschak, A; Sreekrishnan, TR; Srinivasan, M; Staruschenko, A; Steel, A; Stefan-van Staden, RI; Stein, AM; Strayer, H; Struthers, AD; Su, H; Su, Q; Su, X; Sudore, RL; Sugimura, H; Sugiyama, Y; Sujuti, H; Sumner, SJ; Sun, B; Sun, D; Sun, H; Sun, J; Sun, JY; Sun, X; Sun, Y; Sun, Z; Sung, YC; Surenaud, M; Sutimantanapi, D; Suwandaratne, NS; Swaroop, S; Sychrova, H; Syed, A; Szczepanik, M; Szederjesi, J; Szodorai, R; Tacy, TA; Tadelle, RM; Takayasu, M; Tammeveski, K; Tan, H; Tan, M; Tang, HX; Tang, S; Tang, X; Tanokura, M; Tao, F; Tao, H; Tarafdari, A; Tarín-Carrasco, P; Tasson Tatang, C; Teixeira, JP; Thakur, A; Theobald, A; Thevenot, P; Thomaidis, K; Tian, J; Tillib, SV; Toma, C; Tomita, M; Tonchev, I; Tong, F; Toy, W; Trypuć, M; Tselepis, AD; Tsetseris, L; Tsikouri, GE; Tsikouris, EI; Tsoplifack, CB; Tsoumani, ME; Tsujimoto, R; Tsybin, YO; Tu, J; Tu, TM; Turco, M; Turkyilmaz, IB; Uddin, MJ; Ung, J; Unsihuay, D; Utsunomiya, T; Vagenende, B; Vaishnav, J; Valdes, C; Validad, MH; Valle, J; van Ginkel, MPH; van Grevenstein, WMU; Vanderpuye, V; Vasan, N; Vasilenko, EA; Vasques, GJ; Vavoulis, P; Verani, A; Veziroglu, E; Viegas, A; Vitali, MG; Vitsas, G; Voccio, JP; Vogiatzidis, C; Volow, A; Volpin, F; Vourvahis, M; Wagner, LI; Walkowiak, J; Wallace, R; Wallentin, L; Wan, D; Wan, L; Wan, T; Wang, C; Wang, F; Wang, FN; Wang, H; Wang, J; Wang, L; Wang, Q; Wang, S; Wang, T; Wang, W; Wang, X; Wang, XW; Wang, Y; Wang, YS; Wang, Z; Ward, J; Ward, L; Waseem, R; Watson, DF; Weber, P; Wehrmeister, FC; Wei, CH; Wei, H; Wei, L; Wei, Q; Wei, Y; Weinstock, RS; Weiss, M; Welborn, M; Wen, L; Wen, LM; Wen, Q; Wen, Z; Wesseling, P; Westerbergh, J; White, K; Wick, MP; Willems, S; Wiyasa, IWA; Wójciak, R; Wolkenhauer, O; Won, HH; Wong, J; Woo, YC; Wood, LS; Wu, CT; Wu, CY; Wu, D; Wu, G; Wu, J; Wu, K; Wu, M; Wu, Q; Wu, T; Wu, W; Wu, X; Wu, XT; Wu, Y; Xi, D; Xi, J; Xiang, W; Xiang, Y; Xiao, M; Xiao, Z; Xie, H; Xie, Q; Xie, S; Xie, X; Xing, M; Xing, YL; Xu, C; Xu, X; Xu, Y; Xu, Z; Xue, F; Xue, XD; Yaglioglu, HG; Yamada, H; Yamashita, M; Yan, W; Yan, Z; Yanardag, R; Yang, D; Yang, H; Yang, K; Yang, QQ; Yang, R; Yang, S; Yang, T; Yang, X; Yang, Y; Yao, H; Yao, Y; Yari, D; Yassin, MT; Ye, C; Ye, J; Ye, Q; Yildiz, EA; Ying, S; Yoon, H; Yu, D; Yu, K; Yu, N; Yu, PL; Yuan, C; Yuan, D; Yuan, LJ; Yuan, Z; Yuen, N; Zagatto, AM; Zakaria, Y; Zalewski, AM; Zamora, S; Zavorotinskaya, T; Zeid, JL; Zeinoun, T; Zeng, C; Zerby, HN; Zhan, X; Zhang, A; Zhang, D; Zhang, E; Zhang, F; Zhang, H; Zhang, J; Zhang, L; Zhang, M; Zhang, P; Zhang, Q; Zhang, QY; Zhang, RG; Zhang, S; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, CK; Zhao, H; Zhao, J; Zhao, K; Zhao, Q; Zhao, S; Zhao, T; Zhao, XQ; Zhao, Y; Zhao, Z; Zheng, J; Zheng, L; Zheng, Y; Zhou, B; Zhou, G; Zhou, L; Zhou, T; Zhou, X; Zhu, C; Zhu, J; Zhu, Y; Zhu, ZQ; Zhuang, T; Zimmermannova, O; Zin, NNINM; Zisimos, K; Zoghebi, KA; Zonder, JA; Zou, C; Zwirner, J	1
Chi, ZF; Kang, AL; Liu, YX; Nie, LH; Niu, CY; Wang, P; Wang, Q; Wei, D; Zhang, H; Zhang, LM; Zhao, M; Zhao, ZA; Zhao, ZG	1
Alcigir, ME; Bakar-Ates, F; Ekim, O; Hascicek, C; Sengel-Turk, CT	1
D'Ascenzo, N; Han, S; He, Z; Hu, X; Jacob, C; Liang, X; Liu, Q; Ni, J; Wan, L; Xiao, P; Xiao, W; Xie, Q	1
Higuchi, T; Hoffman, RM; Kanaya, F; Miyake, K; Nishida, K; Oshiro, H; Sugisawa, N; Tome, Y	1
Bui, NQ; Chawla, N; Seetharam, M	1
Ren, C; Wang, Y; Xiu, J; Yang, T; Yu, Z	1
Choe, SW; Kim, MJ; Kim, YH; Lee, YJ; P Oh, S; Sprecher, D	1
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Bortolanza, M; Cavalcanti-Kiwiatkoski, R; da-Silva, CA; Del-Bel, E; Mitkovski, M; Padovan-Neto, FE; Raisman-Vozari, R	1
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Czarnecka, A; Konieczny, J; Lenda, T; Lorenc-Koci, E	1
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Huang, X; Li, W; Tan, Z; Wang, H; Wang, J; Yu, R; Zhang, L; Zhang, Y; Zhong, J	1
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Carter, PH; Hynes, J	1
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Dworzański, W; Jaskólska, A; Zółkowska, D; Łuszczki, JJ	1
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Dinarte, AR; Ferreira, FR; Greene, LJ; Guimarães, FS; Joca, SR; Oliveira, AM; Pinheiro, DG; Silva, WA	1
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Assreuy, J; Cabrini, DA; Horinouchi, CD; Mendes, DA; Otuki, MF; Prudente, Ada S; Soley, Bda S	1
Hayward, R; Marais, R; Martin, MJ; Viros, A	1
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Cho, WK; Choi, HS; Kang, S; Kim, SH; Park, KC; Roh, CR; Roh, YJ; Yang, KJ	1
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Cheng, CY; Liu, T; Mruk, DD; Shao, J; Silvestrini, B; Wang, B; Xia, W; Xie, QR; Ying, W; Yu, H; Zhang, T	1
Aoyama, K; Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T; Sakamaki, K; Watabe, M	1
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Morishima, Y; Sato, T; Shirasaki, Y	1
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Fukunaga, K; Hamada, J; Hashiguchi, A; Kawano, T; Morioka, M; Sato, T; Shirasaki, Y; Ushio, Y; Yano, S	1
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Bhatia, M; Chevali, L; Guglielmotti, A; Ramnath, RD	1
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Chang, JH; Chang, YL; Cheng, FC; Guh, JH; Kuo, SC; Lee, FY; Pan, SL; Peng, CY; Teng, CM	1
Bothma, T; Harvey, BH; Nel, A; Stein, DJ; Wegener, G	1
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Dantanarayana, AP; May, JA; McLaughlin, MA; Sharif, NA; Zinke, PW	1
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Albert, DH; Fesik, SW; Li, L; Lin, X; Shen, Y; Shoemaker, AR	1
Chang, CP; Cheng, BC; Lee, CC; Lin, MT	1
Encinas, JM; Fernández, AP; Martínez, A; Rodrigo, J; Serrano, J	1
Fukunaga, K; Han, F; Kasahara, J; Moriguchi, S; Shioda, N; Shirasaki, Y	1
Bayburt, EK; Bianchi, B; Brown, B; Chandran, P; Cui, M; Decker, MW; Faltynek, CR; Gauvin, D; Gomtsyan, A; Hernandez, G; Honore, P; Lee, CH; Marsh, K; McDonald, H; Mikusa, J; Moreland, RB; Neelands, TR; Niforatos, W; Sullivan, JP; Zhong, C	1
Benigno, A; Crescimanno, G; Di Giovanni, G; Di Matteo, V; Esposito, E; Giuliano, DA; Pierucci, M	1
Kang, TH; Kim, S; Park, JS; Suh, YG; Yu, KA	1
Jin, FG; Liu, W; Qian, GS	1
Bancalari, E; Ladino, J; Suguihara, C	1
Ferraro, G; Sardo, P	1
Agar, E; Ayyildiz, M; Bosnak, M; Yildirim, M	1
Flumerfelt, BA; Hrycyshyn, AW; Rajakumar, B; Rajakumar, N	1
Cai, HH; Han, X; Hu, M; Hua, Y; Jiang, J; Luo, CX; Sun, YJ; Wang, B; Wang, W; Zhou, QG; Zhu, DY; Zhu, XJ	1
Brown, RD; Carlström, M; Edlund, J; Larsson, E; Palm, F; Persson, AE; Sällström, J; Teerlink, T; Wåhlin, N	1
Beitz, AJ; Han, HJ; Kim, HW; Kwon, YB; Lee, HJ; Lee, JH; Roh, DH; Seo, HS; Yoon, SY	1
Aoyama, K; Matsumura, N; Nakaki, T; Watabe, M	1
Araki, T; Kato, H; Takagi, S; Watanabe, Y; Yokoyama, H	1
Dunbar, GL; Haik, KL; Hargrove, C; Mazei-Robison, M; Patton, J; Sandstrom, MI; Shear, DA	1
Falk, A; Larsson, A; Risberg, B; Schützer, KM	1
Andresen, CJ; Smith, WB; Swindell, AC; Turner, CR; Watson, JW	1
Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB	1
Snyder, SH	1
Beal, MF; Brouillet, E; Dolan, R; Ferrante, R; Hantraye, P; Matthews, RT; Palfi, S	1
Chapman, AG; Man, CM; Meldrum, BS; Smith, SE; Tang, E; Yip, PK	1
Hicks, C; O'Neill, MJ; Ward, M	1
Ko, FN; Kuo, SC; Lee, FY; Teng, CM; Wu, CC	1
Kimes, AS; London, ED; Vaupel, DB	1
Fouyas, IP; Kelly, PA; Ritchie, IM; Whittle, IR	1
Koedel, U; Paul, R; Pfister, HW	1
Berend, N; Matheson, MJ; McClean, MA; Rynell, AC	1
Montécot, C; Nanri, K; Pinard, E; Seylaz, J; Springhetti, V	1
Ikeda, K; Iwasaki, Y; Kinoshita, M	1
Boireau, A; Bordier, F; Dubedat, P; Imperato, A; Moussaoui, S	1
Ali, SF; Imam, SZ; Islam, F; Itzhak, Y; Slikker, W	1
Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J	1
Fujii, M; Fujisawa, H; Ito, H; Suzuki, M; Yasuda, H	1
Alonso-Alija, C; Apeler, H; Becker, EM; Dembowsky, K; Feurer, A; Gerzer, R; Minuth, T; Perzborn, E; Pleiss, U; Schramm, M; Schröder, H; Schroeder, W; Stahl, E; Stasch, JP; Steinke, W; Straub, A	1
Feustel, PJ; Kimelberg, HK; Mongin, AA; Osuka, K; Tranmer, BI	1
Corbalán, R; Córdoba, J; Felipo, V; López-Talavera, J; Martinez, L; Monfort, P	1
Chang, YS; Lee, M; Park, WS	1
Narita, K; Sano, K; Sato, T; Shirasaki, Y; Takagi, K; Tamura, A	1
Bekemeier, H; Hirschelmann, R; Reimann, S; Schobess, B	1
Silvestrini, B	1

Reviews

3 review(s) available for indazoles and Disease Models, Animal

Article	Year
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors. Annales medico-psychologiques, 2021, Volume: 179, Issue:2 Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses	2021
Evolving role of entrectinib in treatment of Future oncology (London, England), 2021, Volume: 17, Issue:22 Topics: Animals; Benzamides; Cell Line, Tumor; Clinical Trials as Topic; Disease Models, Animal; Drug Approval; Drug Evaluation, Preclinical; Humans; Indazoles; Membrane Glycoproteins; Molecular Targeted Therapy; Neoplasms; Oncogene Proteins, Fusion; Progression-Free Survival; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptor, trkA; Receptor, trkB; Receptor, trkC	2021
DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart. Cardiovascular drug reviews, 2006,Summer, Volume: 24, Issue:2 Topics: Animals; Calmodulin; Cardiotonic Agents; Disease Models, Animal; Humans; Indazoles; Models, Cardiovascular; Molecular Structure; Myocardial Ischemia; Myocardial Reperfusion Injury	2006

Trials

1 trial(s) available for indazoles and Disease Models, Animal

Article

Year

Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.

Annales medico-psychologiques, 2021, Volume: 179, Issue:2

Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses

2021

Other Studies

242 other study(ies) available for indazoles and Disease Models, Animal

Article	Year
Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models. International journal of molecular sciences, 2021, Sep-22, Volume: 22, Issue:19 Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chemokine CCL2; Disease Models, Animal; Down-Regulation; Drug Repositioning; Endotoxemia; Gene Expression Regulation; Indazoles; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Piperazines; Platelet Activation; Pyridines; Pyrrolidines; RAW 264.7 Cells; Transcriptome; Triazoles; Tumor Necrosis Factor-alpha	2021
Chronic stress induces platinum and Niraparib resistance in mouse models of ovarian cancer. Experimental cell research, 2022, 01-15, Volume: 410, Issue:2 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Indazoles; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Models, Biological; Ovarian Neoplasms; Piperidines; Platinum; Stress, Psychological	2022
Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway. Biochimica et biophysica acta. Molecular cell research, 2022, Volume: 1869, Issue:4 Topics: Animals; Apoptosis; Cell Line; Co-Repressor Proteins; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Humans; Indazoles; Kidney; LIM Domain Proteins; Male; Mice; Mice, Inbred C57BL; Nephritis, Interstitial; Piperazines; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction	2022
Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy. European journal of medicinal chemistry, 2022, Feb-05, Volume: 229 Topics: Animals; Brain; Disease Models, Animal; Drug Discovery; Humans; Indazoles; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lung; Male; Mice; Molecular Docking Simulation; Mutation; Neuroprotective Agents; Parkinson Disease; Phenotype; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Rodentia; Structure-Activity Relationship	2022
The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022, 03-02, Volume: 42, Issue:9 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Disease Models, Animal; Female; Humans; Hydrocephalus; Indazoles; Mice; Microglia; Pregnancy; Propionates	2022
DL0805-1, a novel Rho-kinase inhibitor, attenuates lung injury and vasculopathy in a rat model of monocrotaline-induced pulmonary hypertension. European journal of pharmacology, 2022, Mar-15, Volume: 919 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bosentan; Disease Models, Animal; Hypertension, Pulmonary; Indazoles; Male; Monocrotaline; Nitriles; Protein Kinase Inhibitors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Vasodilator Agents	2022
Bindarit encapsulated nanoparticles prevent venous neointimal hyperplasia and restenosis in a murine angioplasty model. Translational research : the journal of laboratory and clinical medicine, 2022, Volume: 248 Topics: Angioplasty; Animals; Arteriovenous Fistula; Chromatography, Liquid; Constriction, Pathologic; Disease Models, Animal; Hyperplasia; Indazoles; Mice; Nanoparticles; Neointima; Propionates; Renal Dialysis; Tandem Mass Spectrometry	2022
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment. European journal of medicinal chemistry, 2022, Nov-05, Volume: 241 Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha	2022
CCL2 is required for initiation but not persistence of HIV infection mediated neurocognitive disease in mice. Scientific reports, 2023, 04-21, Volume: 13, Issue:1 Topics: AIDS Dementia Complex; Animals; Chemokine CCL2; Cognition; Disease Models, Animal; HIV Infections; Indazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Receptors, CCR2	2023
Effects of extended-release 7-nitroindazole gel formulation treatment on the behavior of Shank3 mouse model of autism. Nitric oxide : biology and chemistry, 2023, Nov-01, Volume: 140-141 Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Indazoles; Mice; Microfilament Proteins; Nerve Tissue Proteins	2023
Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl-xL inhibition. EMBO molecular medicine, 2019, Volume: 11, Issue:10 Topics: Animals; Apoptosis; bcl-X Protein; Benzoates; Benzylamines; Carcinoma; Cell Proliferation; Cell Respiration; Disease Models, Animal; Gene Expression Profiling; Glioblastoma; Humans; Indazoles; Liver X Receptors; Melanoma; Metabolomics; Models, Theoretical; Treatment Outcome	2019
Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity. Biomolecules, 2019, 09-16, Volume: 9, Issue:9 Topics: Animals; Disease Models, Animal; Edema; Feeding Behavior; Indazoles; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Molecular Structure; Rats; Receptors, Cannabinoid; Rimonabant; Valine; Zymosan	2019
Denitrosylation of nNOS induced by cerebral ischemia-reperfusion contributes to nitrosylation of CaMKII and its inhibition of autophosphorylation in hippocampal CA1. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:17 Topics: Animals; CA1 Region, Hippocampal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Dizocilpine Maleate; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; S-Nitrosoglutathione	2019
A CXCR4 receptor agonist strongly stimulates axonal regeneration after damage. Annals of clinical and translational neurology, 2019, Volume: 6, Issue:12 Topics: Animals; Axons; Benzylamines; Chemokine CXCL12; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Indazoles; Mice; Mice, Inbred C57BL; Nerve Regeneration; Piperidines; Pyridines; Receptors, CXCR4; Schwann Cells; Sciatic Nerve; Sciatic Neuropathy	2019
Species differences in ocular pharmacokinetics and pharmacological activities of regorafenib and pazopanib eye-drops among rats, rabbits and monkeys. Pharmacology research & perspectives, 2019, Volume: 7, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Choroidal Neovascularization; Crystallization; Disease Models, Animal; Drug Evaluation, Preclinical; Eye; Female; Humans; Indazoles; Macaca fascicularis; Macular Degeneration; Male; Nanoparticles; Ophthalmic Solutions; Particle Size; Phenylurea Compounds; Pyridines; Pyrimidines; Rabbits; Rats; Receptors, Vascular Endothelial Growth Factor; Species Specificity; Sulfonamides; Vascular Endothelial Growth Factor A	2019
Chronic NOS Inhibition Affects Oxidative State and Antioxidant Response Differently in the Kidneys of Young Normotensive and Hypertensive Rats. Oxidative medicine and cellular longevity, 2019, Volume: 2019 Topics: Animals; Antioxidants; Cells, Cultured; Disease Models, Animal; Humans; Hypertensive Retinopathy; Indazoles; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar	2019
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay. Drug research, 2020, Volume: 70, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociception; Nociceptors; Pain; Pain Measurement	2020
Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Scientific reports, 2020, 03-12, Volume: 10, Issue:1 Topics: Aged; Animals; Arthritis, Rheumatoid; Autophagy-Related Proteins; Disease Models, Animal; Female; HEK293 Cells; Humans; Indazoles; Inhibitory Concentration 50; Mice; Middle Aged; Monocytes; NADPH Oxidases; Oxidative Stress; Protein Binding; RAW 264.7 Cells; Reactive Oxygen Species; Synovial Fluid; Thiadiazoles	2020
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis. PLoS neglected tropical diseases, 2020, Volume: 14, Issue:4 Topics: Animals; Antiparasitic Agents; Click Chemistry; Disease Models, Animal; Drug Discovery; Female; Giardia lamblia; Giardiasis; Indazoles; Intestine, Small; Male; Mice, Inbred C57BL; Parasite Load; Protein Binding; Proteomics; Protozoan Proteins	2020
Upregulated C-C Motif Chemokine Ligand 2 Promotes Ischemic Stroke via Chemokine Signaling Pathway. Annals of vascular surgery, 2020, Volume: 68 Topics: Animals; Brain; Chemokine CCL2; Disease Models, Animal; Humans; Indazoles; Infarction, Middle Cerebral Artery; Locomotion; Male; Neuroprotective Agents; Propionates; Protein Interaction Maps; Rats, Sprague-Dawley; Signal Transduction; Transcriptome; Up-Regulation	2020
Mild microwave ablation combined with HSP90 and TGF‑β1 inhibitors enhances the therapeutic effect on osteosarcoma. Molecular medicine reports, 2020, Volume: 22, Issue:2 Topics: Animals; Apoptosis; Benzamides; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Glycine; HSP90 Heat-Shock Proteins; Humans; Imidazoles; Indazoles; Microwaves; Osteosarcoma; Quinoxalines; Rabbits; Radiofrequency Ablation; Transforming Growth Factor beta1; Tumor Burden	2020
Inhibition of Histone Methyltransferase EZH2 Suppresses Endometriotic Vesicle Development in a Rat Model of Endometriosis. Reproductive sciences (Thousand Oaks, Calif.), 2020, Volume: 27, Issue:9 Topics: Animals; Disease Models, Animal; Endometriosis; Endometrium; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; Indazoles; Pyridones; Rats; Rats, Sprague-Dawley	2020
Transcriptome Analysis Revealed Inflammation Is Involved in the Impairment of Human Umbilical Vein Endothelial Cells Induced by Post-hemorrhagic Shock Mesenteric Lymph. Frontiers in immunology, 2020, Volume: 11 Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; Gene Expression Profiling; Gene Regulatory Networks; Human Umbilical Vein Endothelial Cells; Humans; Indazoles; Inflammation; Lymph; Lymphatic System; Male; Mesentery; Propionates; Rats, Wistar; Shock, Hemorrhagic; Signal Transduction; Transcriptome	2020
Clinicopathological and immunohistochemical evaluation of lonidamine-entrapped lipid-polymer hybrid nanoparticles in treatment of benign prostatic hyperplasia: An experimental rat model. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2020, Volume: 157 Topics: Animals; Apoptosis; Disease Models, Animal; Drug Compounding; Enzyme Inhibitors; Hexokinase; Indazoles; Lipids; Liver; Male; Nanomedicine; Nanoparticles; Polymers; Prostate; Prostatic Hyperplasia; Rats	2020
Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease. International journal of molecular sciences, 2021, Jan-28, Volume: 22, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line; Disease Models, Animal; Female; Hexokinase; Humans; Indazoles; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Transgenic; Nigericin; Positron-Emission Tomography; Thiazolidines; Thiones; Up-Regulation	2021
An mTOR and VEGFR inhibitor combination arrests a doxorubicin resistant lung metastatic osteosarcoma in a PDOX mouse model. Scientific reports, 2021, 04-21, Volume: 11, Issue:1 Topics: Adolescent; Animals; Antibiotics, Antineoplastic; Bone Neoplasms; Disease Models, Animal; Doxorubicin; Drug Resistance, Neoplasm; Drug Therapy, Combination; Everolimus; Female; Humans; Indazoles; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Osteosarcoma; Pyrimidines; Receptors, Vascular Endothelial Growth Factor; Sulfonamides; TOR Serine-Threonine Kinases	2021
HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression. Reproductive biology and endocrinology : RB&E, 2021, Jun-09, Volume: 19, Issue:1 Topics: Aminopyridines; Animals; Blotting, Western; Cell Count; Cell Line; Cell Movement; Cell Proliferation; Disease Models, Animal; Endometriosis; Female; Gene Knockdown Techniques; Glucose; Glycolysis; Heat Shock Transcription Factors; Humans; Indazoles; Lactic Acid; Mice; Phosphofructokinase-2; Real-Time Polymerase Chain Reaction; Up-Regulation	2021
Selective effects of oral antiangiogenic tyrosine kinase inhibitors on an animal model of hereditary hemorrhagic telangiectasia. Journal of thrombosis and haemostasis : JTH, 2017, Volume: 15, Issue:6 Topics: Activin Receptors, Type I; Activin Receptors, Type II; Administration, Oral; Administration, Topical; Anemia; Angiogenesis Inhibitors; Animals; Arteriovenous Malformations; Disease Models, Animal; Erlotinib Hydrochloride; Gastrointestinal Hemorrhage; Hemoglobins; Image Processing, Computer-Assisted; Indazoles; Mice; Mice, Knockout; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrimidines; Skin; Sorafenib; Sulfonamides; Sulfones; Telangiectasia, Hereditary Hemorrhagic; Tyrosine; Vascular Endothelial Growth Factor A; Wound Healing	2017
Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents. European journal of medicinal chemistry, 2017, Sep-29, Volume: 138 Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; ERRalpha Estrogen-Related Receptor; Hypoglycemic Agents; Indazoles; Ligands; Male; Mice; Mice, Obese; Molecular Structure; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Estrogen; Structure-Activity Relationship	2017
A Pharmacodynamic Analysis of Choroidal Neovascularization in a Porcine Model Using Three Targeted Drugs. Investigative ophthalmology & visual science, 2017, 07-01, Volume: 58, Issue:9 Topics: Angiogenesis Inhibitors; Animals; Bevacizumab; Choroidal Neovascularization; Disease Models, Animal; Fluorescein Angiography; Immunoconjugates; Indazoles; Intravitreal Injections; Pyrimidines; Sulfonamides; Swine; T-Lymphocytes, Cytotoxic; Vascular Endothelial Growth Factor A	2017
Calmodulin inhibitor ameliorates cognitive dysfunction via inhibiting nitrosative stress and NLRP3 signaling in mice with bilateral carotid artery stenosis. CNS neuroscience & therapeutics, 2017, Volume: 23, Issue:10 Topics: Amines; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Carotid Stenosis; Caspase 1; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Drug Carriers; Hippocampus; Indazoles; Inflammasomes; Interleukin-1beta; Male; Mice, Inbred C57BL; Micelles; Nitrosative Stress; NLR Family, Pyrin Domain-Containing 3 Protein; Nootropic Agents; Phosphorylation; Piperazines; Sialic Acids	2017
Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy. Journal of Alzheimer's disease : JAD, 2017, Volume: 60, Issue:2 Topics: Animals; Astrocytes; Calcium-Binding Proteins; Cell Line, Tumor; Cognition; Collagen Type IV; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glial Fibrillary Acidic Protein; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Motor Activity; Mutation; Neuroblastoma; Phosphorylation; Pyrimidines; Receptors, Vascular Endothelial Growth Factor; RNA, Small Interfering; Silver Staining; Sulfonamides; tau Proteins; Tauopathies; Transfection; Treatment Outcome	2017
Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses. Laboratory investigation; a journal of technical methods and pathology, 2017, Volume: 97, Issue:12 Topics: Allyl Compounds; Animals; Cells, Cultured; Cytoplasm; Disease Models, Animal; Gout; Indazoles; Inflammation; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Knockout; Receptors, Aryl Hydrocarbon	2017
Axitinib attenuates intraplaque angiogenesis, haemorrhages and plaque destabilization in mice. Vascular pharmacology, 2018, Volume: 100 Topics: Animals; Arteries; Atherosclerosis; Axitinib; Cell Adhesion Molecules; Cells, Cultured; Coronary Artery Disease; Disease Models, Animal; Female; Fibrillin-1; Genetic Predisposition to Disease; Hemorrhage; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Indazoles; Mice, Knockout, ApoE; Myocardial Infarction; Neovascularization, Pathologic; Phenotype; Plaque, Atherosclerotic; Protein Kinase Inhibitors; Receptors, Vascular Endothelial Growth Factor; Rupture, Spontaneous; Signal Transduction; Ventricular Function, Left	2018
Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorganic & medicinal chemistry letters, 2017, 12-01, Volume: 27, Issue:23 Topics: Acute Lung Injury; Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Hep G2 Cells; Hepcidins; Humans; Indazoles; Inflammation; Interleukin-6; Mice; Molecular Structure; Pyrazoles; Structure-Activity Relationship	2017
Repeated treatment with nitric oxide synthase inhibitor attenuates learned helplessness development in rats and increases hippocampal BDNF expression. Acta neuropsychiatrica, 2018, Volume: 30, Issue:3 Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Enzyme Inhibitors; Helplessness, Learned; Hippocampus; Imipramine; Indazoles; Nitric Oxide Synthase; Rats	2018
Pazopanib for renal cell carcinoma leads to elevated mean arterial pressures in a murine model. Clinical and experimental hypertension (New York, N.Y. : 1993), 2018, Volume: 40, Issue:6 Topics: Angiogenesis Inhibitors; Animals; Arterial Pressure; Body Weight; Carcinoma, Renal Cell; Cardiac Output; Disease Models, Animal; Echocardiography; Electrocardiography; Heart; Hypertension; Indazoles; Kidney; Kidney Neoplasms; Mice; Myocardium; Pyrimidines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sulfonamides; Vascular Endothelial Growth Factor A	2018
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science (New York, N.Y.), 2017, 12-08, Volume: 358, Issue:6368 Topics: Animals; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Hypertension, Renal; Indazoles; Mutation; Podocytes; Proteinuria; rac1 GTP-Binding Protein; Rats; Rats, Inbred Dahl; Rats, Transgenic; Small Molecule Libraries; TRPC Cation Channels	2017
Bindarit Attenuates Pain and Cancer-Related Inflammation by Influencing Myeloid Cells in a Model of Bone Cancer. Archivum immunologiae et therapiae experimentalis, 2018, Volume: 66, Issue:3 Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinogenesis; Cell Line, Tumor; Chemokine CCL2; Disease Models, Animal; Humans; I-kappa B Kinase; Indazoles; Inflammation; Male; Mice; Mice, Nude; Myeloid Cells; Neoplasms, Experimental; Propionates; Signal Transduction; Tumor Burden	2018
Adrenomedullin serves a role in the humoral pathway of delayed remote ischemic preconditioning via a hypoxia-inducible factor-1α-associated mechanism. Molecular medicine reports, 2018, Volume: 17, Issue:3 Topics: Adrenomedullin; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indazoles; Ischemic Preconditioning; Kidney; Male; Malondialdehyde; Pyrazoles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Triazoles; Up-Regulation	2018
Renal physiology: TRPC5 inhibition to treat progressive kidney disease. Nature reviews. Nephrology, 2018, Volume: 14, Issue:3 Topics: Animals; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Hypertension, Renal; Indazoles; Mutation; Podocytes; Proteinuria; rac1 GTP-Binding Protein; Rats; Rats, Inbred Dahl; Rats, Transgenic; Small Molecule Libraries; TRPC Cation Channels	2018
YC-1 Inhibits VEGF and Inflammatory Mediators Expression on Experimental Central Retinal Vein Occlusion in Rhesus Monkey. Current eye research, 2018, Volume: 43, Issue:4 Topics: Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Follow-Up Studies; Guanylate Cyclase; Indazoles; Inflammation; Intravitreal Injections; Macaca mulatta; Platelet Aggregation Inhibitors; Retinal Vein Occlusion; Vascular Endothelial Growth Factor A; Vitreous Body	2018
Foretinib Overcomes Entrectinib Resistance Associated with the Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 05-15, Volume: 24, Issue:10 Topics: Amino Acid Substitution; Anilides; Animals; Benzamides; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Heterografts; Humans; Indazoles; Mice; Models, Molecular; Mutation; Oncogene Proteins, Fusion; Quinolines; Receptor, trkA; Structure-Activity Relationship	2018
The multi-receptor inhibitor axitinib reverses tumor-induced immunosuppression and potentiates treatment with immune-modulatory antibodies in preclinical murine models. Cancer immunology, immunotherapy : CII, 2018, Volume: 67, Issue:5 Topics: Animals; Antibodies, Monoclonal; Axitinib; Carcinoma, Lewis Lung; Disease Models, Animal; Drug Synergism; Hepatitis A Virus Cellular Receptor 2; Imidazoles; Immunosuppression Therapy; Immunotherapy; Indazoles; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Receptors, Vascular Endothelial Growth Factor; Tumor Cells, Cultured; Tumor Necrosis Factor Receptor Superfamily, Member 9; Vascular Endothelial Growth Factor A	2018
Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm. JCI insight, 2018, 03-08, Volume: 3, Issue:5 Topics: Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Disease Models, Animal; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fibrillin-1; Gene Knockout Techniques; Histones; Humans; Indazoles; Losartan; Marfan Syndrome; Mice; Mice, Knockout; Microfilament Proteins; Muscle Contraction; Muscle Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pyridones; RNA, Small Interfering	2018
Second-Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018, Volume: 33, Issue:8 Topics: Adaptor Proteins, Signal Transducing; Animals; Bone and Bones; Cherubism; Disease Models, Animal; Indazoles; Inflammation; Mice; Protein Kinase Inhibitors; Pyrazines; Syk Kinase	2018
TAS05567, a Novel Potent and Selective Spleen Tyrosine Kinase Inhibitor, Abrogates Immunoglobulin-Mediated Autoimmune and Allergic Reactions in Rodent Models. The Journal of pharmacology and experimental therapeutics, 2018, Volume: 366, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Animals; Autoimmune Diseases; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Female; Humans; Hypersensitivity; Indazoles; Male; Mice; Phosphorylation; Protein Kinase Inhibitors; Rats; Receptors, Fc; Signal Transduction; Syk Kinase	2018
EZH2 Inhibition Ameliorates Transverse Aortic Constriction-Induced Pulmonary Arterial Hypertension in Mice. Canadian respiratory journal, 2018, Volume: 2018 Topics: Animals; Aorta; Arterial Pressure; Constriction; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Indazoles; Lung; Male; Mice; Pulmonary Artery; Pyridones; Reactive Oxygen Species; Superoxide Dismutase-1	2018
Adjudin Attenuates Cerebral Edema and Improves Neurological Function in Mice with Experimental Traumatic Brain Injury. Journal of neurotrauma, 2018, 12-01, Volume: 35, Issue:23 Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries, Traumatic; Disease Models, Animal; Hydrazines; Indazoles; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Recovery of Function	2018
Neuronal nitric oxide synthase inhibition reduces brain damage by promoting collateral recruitment in a cerebral hypoxia-ischemia mice model. European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:10 Topics: Animals; Brain Injuries; Cerebral Cortex; Collateral Circulation; Disease Models, Animal; Hemodynamics; Hypoxia-Ischemia, Brain; Indazoles; Male; Mice; Mice, Knockout; Nitric Oxide Synthase Type I	2018
Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain. Journal of neuroinflammation, 2018, Jul-05, Volume: 15, Issue:1 Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Benzoxazines; Brain; Caspase 3; Cells, Cultured; Central Nervous System Depressants; Chemokine CCL2; Disease Models, Animal; Encephalitis; Ethanol; Gene Expression Regulation, Developmental; Indazoles; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Propionates; Receptors, CCR2; Signal Transduction; Spiro Compounds	2018
Macrophages confer resistance to PI3K inhibitor GDC-0941 in breast cancer through the activation of NF-κB signaling. Cell death & disease, 2018, 07-24, Volume: 9, Issue:8 Topics: Animals; Aspirin; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease Models, Animal; Female; Indazoles; Lung Neoplasms; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; RAW 264.7 Cells; Signal Transduction; Sulfonamides	2018
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106 Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Homocysteine; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidation-Reduction; Rats, Inbred SHR	2018
SYK inhibitor entospletinib prevents ocular and skin GVHD in mice. JCI insight, 2018, 10-04, Volume: 3, Issue:19 Topics: Administration, Oral; Animals; B-Lymphocytes; Disease Models, Animal; Drug Evaluation, Preclinical; Eye; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Indazoles; Mice; Protein Kinase Inhibitors; Pyrazines; Skin; Survival Analysis; Syk Kinase; T-Lymphocytes; Treatment Outcome	2018
Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling. Cell host & microbe, 2018, 10-10, Volume: 24, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Bacterial Proteins; Cord Factors; Disease Models, Animal; Humans; Indazoles; Macrophages; Methyltransferases; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Mycolic Acids; Neovascularization, Pathologic; Pyrimidines; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sulfonamides; Tuberculoma; Zebrafish	2018
(‑)Epigallocatechin‑3‑gallate attenuates anesthesia‑induced memory deficit in young mice via modulation of nitric oxide expression. Molecular medicine reports, 2018, Volume: 18, Issue:6 Topics: Anesthesia; Animals; Antioxidants; Apoptosis; Arginine; Biomarkers; Catechin; Disease Models, Animal; Indazoles; Male; Memory; Memory Disorders; Mice; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Oxidative Stress	2018
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. The Journal of toxicological sciences, 2018, Volume: 43, Issue:11 Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Combination; Ibuprofen; Indazoles; Male; Mice, Inbred Strains; Neurotoxins; Nitric Oxide; Pentylenetetrazole; Pilocarpine; Seizures; Thalidomide	2018
Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorganic & medicinal chemistry letters, 2019, 01-15, Volume: 29, Issue:2 Topics: Amines; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Heterocyclic Compounds; Humans; Imidazoles; Indazoles; Molecular Structure; Renal Insufficiency, Chronic; Structure-Activity Relationship; TRPC Cation Channels	2019
Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment. Osteoarthritis and cartilage, 2019, Volume: 27, Issue:9 Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dyrk Kinases; Humans; Imidazoles; Indazoles; Osteoarthritis, Knee; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats; Wnt Signaling Pathway	2019
Long-term cardiovascular effects of vandetanib and pazopanib in normotensive rats. Pharmacology research & perspectives, 2019, Volume: 7, Issue:3 Topics: Animals; Arterial Pressure; Disease Models, Animal; Drug Administration Schedule; Humans; Hypertension; Indazoles; Male; Piperidines; Pyrimidines; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfonamides	2019
The protective effect of nigeglanine on dextran sulfate sodium-induced experimental colitis in mice and Caco-2 cells. Journal of cellular physiology, 2019, Volume: 234, Issue:12 Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Agents; Heterocyclic Compounds, 3-Ring; Humans; Indazoles; Inflammation Mediators; Intestinal Mucosa; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Signal Transduction; Tight Junctions	2019
The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 117 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease Models, Animal; Docetaxel; Doxorubicin; Drug Resistance, Neoplasm; Gemcitabine; Heterografts; Humans; Indazoles; Liposarcoma; Male; Mice; Mice, Nude; Neoplasm Recurrence, Local; Pyrimidines; Sulfonamides; Tumor Burden; Xenograft Model Antitumor Assays	2019
Diffusion tensor imaging identifies aspects of therapeutic estrogen receptor β ligand-induced remyelination in a mouse model of multiple sclerosis. Neurobiology of disease, 2019, Volume: 130 Topics: Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Diffusion Tensor Imaging; Disease Models, Animal; Estrogen Receptor beta; Female; Indazoles; Magnetic Resonance Imaging; Male; Mice; Multiple Sclerosis; Neuroprotective Agents; Remyelination	2019
Relationship between the MAPK/ERK pathway and neurocyte apoptosis after cerebral infarction in rats. European review for medical and pharmacological sciences, 2019, Volume: 23, Issue:12 Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cerebral Infarction; Disease Models, Animal; Humans; Indazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nestin; Neural Stem Cells; Neurons; Piperazines; Primary Cell Culture; Rats	2019
[18F]-FLT positron emission tomography can be used to image the response of sensitive tumors to PI3-kinase inhibition with the novel agent GDC-0941. Molecular cancer therapeutics, 2013, Volume: 12, Issue:5 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dideoxynucleosides; Disease Models, Animal; Female; HCT116 Cells; Humans; Indazoles; Mice; Neoplasm Metastasis; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Positron-Emission Tomography; Signal Transduction; Sulfonamides; Tumor Burden; Xenograft Model Antitumor Assays	2013
Protective effect of HIF-1α against hippocampal apoptosis and cognitive dysfunction in an experimental rat model of subarachnoid hemorrhage. Brain research, 2013, Jun-23, Volume: 1517 Topics: Animals; Apoptosis; Blood Pressure; Caspase 3; Cognition Disorders; Disease Models, Animal; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Excitatory Amino Acid Transporter 2; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Maze Learning; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Reaction Time; Subarachnoid Hemorrhage; Vascular Endothelial Growth Factor A	2013
Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model. Molecular cancer therapeutics, 2013, Volume: 12, Issue:5 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Axitinib; Cell Line, Tumor; Disease Models, Animal; Humans; Hypoxia; Imidazoles; Indazoles; Male; Neoplastic Stem Cells; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; Prostatic Neoplasms; Protein Kinase Inhibitors; Sorafenib; Xenograft Model Antitumor Assays	2013
Heterogeneity of the effects of combined nitric oxide synthase inhibition on organ perfusion in ovine sepsis. Burns : journal of the International Society for Burn Injuries, 2013, Volume: 39, Issue:8 Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Ileum; Indazoles; Lung Diseases; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pancreas; Pseudomonas aeruginosa; Pseudomonas Infections; Random Allocation; Regional Blood Flow; Sepsis; Sheep; Sheep Diseases; Smoke Inhalation Injury; Spleen	2013
Neuroprotection of S-nitrosoglutathione against ischemic injury by down-regulating Fas S-nitrosylation and downstream signaling. Neuroscience, 2013, Sep-17, Volume: 248 Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Caspase 8; Caspase 9; Disease Models, Animal; Down-Regulation; Fas Ligand Protein; fas Receptor; Indazoles; Male; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Reperfusion Injury; S-Nitrosoglutathione; Signal Transduction	2013
Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Indazoles; Maze Learning; Memory Disorders; Memory, Short-Term; Phenylalanine; Piperazines; Protein Binding; Pyridines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Recognition, Psychology; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Sulfides; Time Factors; Tritium; Tropanes; Vortioxetine	2014
Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors. BMC cancer, 2013, Aug-10, Volume: 13 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; Fluorescent Antibody Technique; Humans; Indazoles; Male; Mice; Mice, Nude; Neoplasms, Germ Cell and Embryonal; Pyrimidines; Real-Time Polymerase Chain Reaction; Sulfonamides; Testicular Neoplasms; Xenograft Model Antitumor Assays	2013
Inhibition of tumor growth and metastasis in non-small cell lung cancer by LY2801653, an inhibitor of several oncokinases, including MET. Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Oct-15, Volume: 19, Issue:20 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Gene Expression; Hepatocyte Growth Factor; Humans; Indazoles; Lung Neoplasms; Mice; Neoplasm Metastasis; Niacinamide; Oncogene Proteins; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-met; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays	2013
Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats. Neuropharmacology, 2013, Volume: 75 Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Indazoles; Male; Membrane Glycoproteins; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Complement; RNA, Messenger; Sciatica; Spinal Cord; Time Factors	2013
Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model. Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:10 Topics: Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Female; Fetal Growth Retardation; Guanylate Cyclase; Indazoles; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Pre-Eclampsia; Pregnancy; Proteinuria; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Second Messenger Systems; Suramin; Vasodilation; Vasodilator Agents	2013
Activation of NOD2/RIPK2 pathway induces mitochondrial injury to oligodendrocyte precursor cells in vitro and CNS demyelination in vivo. Journal of neuroimmunology, 2013, Dec-15, Volume: 265, Issue:1-2 Topics: Animals; Animals, Newborn; Cerebral Cortex; Corpus Callosum; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Transport Complex I; Electron Transport Complex IV; Gene Expression Regulation; Indazoles; Mitochondria; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nod2 Signaling Adaptor Protein; Oligodendroglia; Peptidoglycan; Rats; Receptor-Interacting Protein Serine-Threonine Kinase 2; Signal Transduction; Stem Cells; Time Factors	2013
Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer. Cancer research, 2014, Feb-01, Volume: 74, Issue:3 Topics: Amino Acid Sequence; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Enzyme Activation; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Indazoles; Lung Neoplasms; Mice; Niacinamide; Peptides; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; STAT3 Transcription Factor; Tumor Burden; Xenograft Model Antitumor Assays	2014
Integrin α(v)β₃-targeted radiotracer (99m)Tc-3P-RGD₂ useful for noninvasive monitoring of breast tumor response to antiangiogenic linifanib therapy but not anti-integrin α(v)β₃ RGD₂ therapy. Theranostics, 2013, Volume: 3, Issue:11 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Disease Models, Animal; Drug Monitoring; Indazoles; Integrin alphaVbeta3; Mice; Phenylurea Compounds; Radioactive Tracers; Tomography, Emission-Computed, Single-Photon; Treatment Outcome	2013
Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration. Behavioural brain research, 2014, Mar-15, Volume: 261 Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Hindlimb Suspension; Immobility Response, Tonic; Indazoles; Mice; Tumor Necrosis Factor-alpha	2014
Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer. Cytokine, 2014, Volume: 66, Issue:1 Topics: Animals; Antigens, Polyomavirus Transforming; Biomarkers; Body Weight; Carcinogenesis; Chemokine CCL2; Disease Models, Animal; Feeding Behavior; Female; Gene Expression Regulation; Indazoles; Inflammation Mediators; Interleukin-6; Macrophages; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mice; Mice, Transgenic; Organ Size; Propionates; RNA, Messenger; Spleen; Tumor Burden; Tumor Necrosis Factor-alpha	2014
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7 Topics: Anilino Naphthalenesulfonates; Animals; Antiprotozoal Agents; Benzamides; Cell Line, Tumor; Disease Models, Animal; Entamoeba histolytica; Entamoebiasis; Giardia lamblia; Giardiasis; Glycine; HSP90 Heat-Shock Proteins; Humans; Indazoles; Jurkat Cells; Mice; Parasitic Sensitivity Tests; Trophozoites	2014
Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption. Journal of neuroinflammation, 2014, Jun-14, Volume: 11 Topics: Animals; Blood-Brain Barrier; Brain; Brain Infarction; CD11b Antigen; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hydrazines; Indazoles; Matrix Metalloproteinase 9; Mice; Microglia; Neurologic Examination; Neuroprotective Agents; Nitric Oxide Synthase Type II; Occludin; Reperfusion Injury; Zonula Occludens-1 Protein	2014
Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), and investigation of the antitumor effects of pazopanib on Hewga-CCS. BMC cancer, 2014, Jun-19, Volume: 14 Topics: Adult; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromosome Breakpoints; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Indazoles; Mice; Oncogene Proteins, Fusion; Proto-Oncogene Proteins c-met; Pyrimidines; Sarcoma, Clear Cell; Signal Transduction; Soft Tissue Neoplasms; Sulfonamides; Transcription Factors; Tumor Burden; Xenograft Model Antitumor Assays	2014
Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. Pharmacological reports : PR, 2014, Volume: 66, Issue:5 Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anxiety; Benzodioxoles; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Guanidines; Indazoles; Male; Maze Learning; Mice; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Piperidines; Polyunsaturated Alkamides; Stress, Psychological	2014
Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice. Biomedical research (Tokyo, Japan), 2014, Volume: 35, Issue:4 Topics: Animals; Disease Models, Animal; Endotoxemia; Gadolinium; Guanidines; Indazoles; Interstitial Cells of Cajal; Intestinal Mucosa; Intestines; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase Type II	2014
Different effects of 7-nitroindazole and L-NAME administered both individually and together on the cardiovascular system of the rat. Physiological research, 2015, Volume: 64, Issue:1 Topics: Animals; Aorta, Thoracic; Blood Pressure; Cardiomegaly; Carotid Arteries; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats, Inbred SHR; Rats, Wistar; Vascular Remodeling; Vasodilation; Ventricular Remodeling	2015
Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice. Neurobiology of disease, 2015, Volume: 73 Topics: Animals; Antiparkinson Agents; Benserazide; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Gene Expression Regulation; Homeodomain Proteins; Indazoles; Levodopa; Mice; Mice, Knockout; Molsidomine; Nitric Oxide Donors; Parkinson Disease; Signal Transduction; Time Factors; Transcription Factors	2015
Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection. Journal of virology, 2015, Volume: 89, Issue:1 Topics: Adult; Aged; Animals; Bone Density Conservation Agents; Bone Resorption; Chemokine CCL2; Chikungunya Fever; Disease Models, Animal; Female; Humans; Indazoles; Male; Mice, Inbred C57BL; Middle Aged; Propionates	2015
Chronic inflammation, lymphangiogenesis, and effect of an anti-VEGFR therapy in a mouse model and in human patients with aspiration pneumonia. The Journal of pathology, 2015, Volume: 235, Issue:4 Topics: Animals; Autopsy; Axitinib; Chronic Disease; Cytokines; Disease Models, Animal; Humans; Imidazoles; Indazoles; Inflammation Mediators; Lung; Lymphangiogenesis; Lymphatic Vessels; Male; Mice, Inbred C57BL; Naphthyridines; Pneumonia, Aspiration; Protein Kinase Inhibitors; Time Factors; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor Receptor-3	2015
Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease. Neurobiology of disease, 2015, Volume: 73 Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Indazoles; Inflammation; Levodopa; Male; Neuroglia; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Parkinson Disease; Rats; Rats, Wistar; Up-Regulation	2015
Effects of MCP-1 inhibition by bindarit therapy in a rat model of polycystic kidney disease. Nephron, 2015, Volume: 129, Issue:1 Topics: Animals; Chemokine CCL2; Disease Models, Animal; In Vitro Techniques; Indazoles; Macrophages; Male; Monocytes; Podocytes; Polycystic Kidney, Autosomal Dominant; Propionates; Proteinuria; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; RNA, Messenger	2015
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis. Science translational medicine, 2015, Jan-21, Volume: 7, Issue:271 Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Embryonic Stem Cells; Endometriosis; Estrogens; Female; Fertility; Humans; Indazoles; Inflammation; Letrozole; Ligands; Macrophages; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nitriles; Receptors, Estrogen; Stromal Cells; Treatment Outcome; Triazoles	2015
Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway. Scientific reports, 2015, Feb-02, Volume: 5 Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Cochlea; Disease Models, Animal; Epithelium; Gentamicins; Hair Cells, Auditory; Hearing Loss; Hydrazines; Immunohistochemistry; Indazoles; Mice; Mice, Inbred C57BL; Organ of Corti; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sirtuin 3; Up-Regulation	2015
Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy. Scientific reports, 2015, Mar-11, Volume: 5 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Axitinib; Cell Line, Tumor; Chick Embryo; Combined Modality Therapy; Cymenes; Disease Models, Animal; Doxorubicin; Drug Synergism; Humans; Imidazoles; Indazoles; Indoles; Neoplasms; Neovascularization, Pathologic; Organometallic Compounds; Oxygen Consumption; Photochemotherapy; Protein Kinase Inhibitors; Pyrroles; Sunitinib; Tumor Burden	2015
A novel water-soluble benzothiazole derivative BD926 inhibits human activated T cell proliferation by down-regulating the STAT5 activation. European journal of pharmacology, 2015, Aug-15, Volume: 761 Topics: Animals; Benzimidazoles; Benzothiazoles; Cell Proliferation; Cells, Cultured; Cyclin D3; Cyclin-Dependent Kinase 6; Cytokines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Female; G1 Phase Cell Cycle Checkpoints; Humans; Immunosuppressive Agents; Indazoles; Lymphocyte Activation; Mice, Inbred BALB C; Phosphorylation; Signal Transduction; Solubility; STAT5 Transcription Factor; T-Lymphocytes; Water	2015
Ellagic Acid Enhances the Efficacy of PI3K Inhibitor GDC-0941 in Breast Cancer Cells. Current molecular medicine, 2015, Volume: 15, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Synergism; Ellagic Acid; Enzyme Inhibitors; Female; Humans; Indazoles; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Sulfonamides; Xenograft Model Antitumor Assays	2015
Effects of Pazopanib, Sunitinib, and Sorafenib, Anti-VEGF Agents, on the Growth of Experimental Endometriosis in Rats. Reproductive sciences (Thousand Oaks, Calif.), 2015, Volume: 22, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Disease Models, Animal; Endometriosis; Endometrium; Female; Indazoles; Indoles; Niacinamide; Ovarian Reserve; Phenylurea Compounds; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Rats, Wistar; Signal Transduction; Sorafenib; Sulfonamides; Sunitinib; Vascular Endothelial Growth Factor A	2015
Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease. Investigative ophthalmology & visual science, 2015, Volume: 56, Issue:5 Topics: Animals; Axitinib; Cornea; Disease Models, Animal; Female; Glycoproteins; Imidazoles; Immunoglobulin E; Indazoles; Keratoconjunctivitis; Lymphangiogenesis; Lymphatic Vessels; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Ovalbumin; Protein Kinase Inhibitors; Real-Time Polymerase Chain Reaction; Vascular Endothelial Growth Factor C; Vascular Endothelial Growth Factor D; Vascular Endothelial Growth Factor Receptor-3	2015
A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response. Pharmacological research, 2015, Volume: 99 Topics: Administration, Inhalation; Animals; Asthma; Azabicyclo Compounds; B-Lymphocytes; Cell Degranulation; Cell Line; Disease Models, Animal; Humans; Indazoles; Intracellular Signaling Peptides and Proteins; Male; Mast Cells; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Inbred BN; Rats, Wistar; Syk Kinase	2015
Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat. Neuroscience, 2015, Sep-10, Volume: 303 Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Hippocampus; Indazoles; Male; Morpholines; Naphthalenes; Nitric Oxide; Nitric Oxide Synthase; Pilocarpine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1	2015
Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways. Pharmacology, biochemistry, and behavior, 2015, Volume: 136 Topics: Animals; Antidepressive Agents; Antioxidants; Arginine; Behavior, Animal; Disease Models, Animal; Drug Synergism; Fluoxetine; Hippocampus; Indazoles; Male; Methylene Blue; Mice; N-Methylaspartate; Olfactory Bulb; Oxidative Stress; Quercetin; Signal Transduction; Sildenafil Citrate	2015
Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice. PloS one, 2015, Volume: 10, Issue:8 Topics: Animals; Antineoplastic Agents; Deoxycytidine; Disease Models, Animal; Gemcitabine; Indazoles; Mice; Mice, Nude; Pyrimidines; Salmonella Infections; Salmonella typhimurium; Sarcoma; Soft Tissue Neoplasms; Sulfonamides; Xenograft Model Antitumor Assays	2015
The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N(G)-nitro-L-arginine methyl ester administered alone or jointly with L-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats. Brain research, 2015, Nov-02, Volume: 1625 Topics: Adrenergic Agents; Animals; Apomorphine; Biogenic Monoamines; Brain; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Indazoles; Levodopa; Locomotion; Male; Movement Disorders; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxidopamine; Rats; Rats, Wistar; Time Factors	2015
VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria. Pathogens and global health, 2015, Volume: 109, Issue:6 Topics: Acute-Phase Proteins; Animals; Axitinib; Carrier Proteins; Disease Models, Animal; Drug Synergism; Imidazoles; Immune Tolerance; Indazoles; Lipopolysaccharides; Malaria, Cerebral; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Parasitemia; Plasmodium berghei; Protein Kinase Inhibitors; T-Lymphocytes, Regulatory; Vascular Endothelial Growth Factor A	2015
Pharmacological targeting of VEGFR signaling with axitinib inhibits Tsc2-null lesion growth in the mouse model of lymphangioleiomyomatosis. American journal of physiology. Lung cellular and molecular physiology, 2015, Dec-15, Volume: 309, Issue:12 Topics: Animals; Axitinib; Cell Line, Tumor; Cell Proliferation; Chemokine CCL2; Disease Models, Animal; Female; Imidazoles; Indazoles; Lung; Lung Diseases; Lung Neoplasms; Lymphangioleiomyomatosis; Mice; Mice, Inbred C57BL; Mice, Nude; Nitric Oxide Synthase Type II; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Up-Regulation; Vascular Endothelial Growth Factor D	2015
Short-term treatment with VEGF receptor inhibitors induces retinopathy of prematurity-like abnormal vascular growth in neonatal rats. Experimental eye research, 2016, Volume: 143 Topics: Animals; Animals, Newborn; Axitinib; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Imidazoles; Indazoles; Microscopy, Fluorescence; Phenylurea Compounds; Pregnancy; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2	2016
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. Brain research bulletin, 2016, Volume: 121 Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Hippocampus; Indazoles; Male; Mice; Naltrexone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Pentylenetetrazole; Seizures; Signal Transduction; Time Factors	2016
NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice. Brain research bulletin, 2016, Volume: 121 Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immobility Response, Tonic; Indazoles; Ketamine; Male; Maze Learning; Mice; Motivation; NG-Nitroarginine Methyl Ester; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Social Isolation; Statistics, Nonparametric; Swimming; Time Factors	2016
Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant-like effect of Wuling mycelia powder in rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 78 Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Feeding Behavior; Food Preferences; Hippocampus; Indazoles; Male; Methylene Blue; Mycelium; Nitric Oxide; Powders; Rats, Sprague-Dawley; Signal Transduction; Sildenafil Citrate; Stress, Psychological; Sucrose	2016
Axitinib inhibits retinal and choroidal neovascularization in in vitro and in vivo models. Experimental eye research, 2016, Volume: 145 Topics: Aged; Animals; Axitinib; Cell Proliferation; Choroidal Neovascularization; Disease Models, Animal; Endothelial Cells; Fluorescein Angiography; Humans; Imidazoles; Immunohistochemistry; Indazoles; Intravitreal Injections; Male; Mesenchymal Stem Cells; Pericytes; Protein Kinase Inhibitors; Rats	2016
Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Molecular cancer therapeutics, 2016, Volume: 15, Issue:4 Topics: Anaplastic Lymphoma Kinase; Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Enzyme Activation; Humans; Indazoles; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic; Mortality; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Translocation, Genetic; Treatment Outcome; Xenograft Model Antitumor Assays	2016
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7 Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Imidazolidines; Indazoles; Iodoacetic Acid; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Osteoarthritis; Pain; Pain Measurement; Pyrroles; Rats; Sodium Channel Blockers; Structure-Activity Relationship	2016
The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Mar-30, Volume: 36, Issue:13 Topics: Animals; Antibodies; Benzoxazines; Chemokine CCL2; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Hippocampus; Indazoles; Inflammation; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Piperidines; Propionates; Receptors, CCR2; RNA, Messenger; Signal Transduction; Up-Regulation	2016
Antidyskinetic Effect of 7-Nitroindazole and Sodium Nitroprusside Associated with Amantadine in a Rat Model of Parkinson's Disease. Neurotoxicity research, 2016, Volume: 30, Issue:1 Topics: Amantadine; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Indazoles; Levodopa; Male; Medial Forebrain Bundle; Microinjections; Nitroprusside; Oxidopamine; Parkinson Disease; Rats	2016
Inhibition on the S-nitrosylation of MKK4 can protect hippocampal CA1 neurons in rat cerebral ischemia/reperfusion. Brain research bulletin, 2016, Volume: 124 Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Disease Models, Animal; Dizocilpine Maleate; Indazoles; Male; MAP Kinase Kinase 4; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion; S-Nitrosoglutathione; Time Factors	2016
Vascular endothelial growth factor partially induces pruritus via epidermal hyperinnervation in imiquimod-induced psoriasiform dermatitis in mice. Journal of dermatological science, 2016, Volume: 83, Issue:2 Topics: Aminoquinolines; Animals; Axitinib; Dermatitis, Atopic; Disease Models, Animal; Epidermis; Humans; Imidazoles; Imiquimod; Indazoles; Mice; Pruritus; Psoriasis; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A	2016
CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours. European radiology, 2017, Volume: 27, Issue:3 Topics: Animals; Axitinib; Disease Models, Animal; Imidazoles; Indazoles; Liver; Liver Neoplasms, Experimental; Male; Protein Kinase Inhibitors; Rabbits; Receptors, Vascular Endothelial Growth Factor; Reproducibility of Results; Tomography, X-Ray Computed; Treatment Outcome	2017
The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer. eLife, 2016, 07-13, Volume: 5 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cinnamates; Disease Models, Animal; Heterografts; Humans; Indazoles; Mice; Prospective Studies; Rats; Receptors, Estrogen; Treatment Outcome	2016
Everolimus affects vasculogenic mimicry in renal carcinoma resistant to sunitinib. Oncotarget, 2016, Jun-21, Volume: 7, Issue:25 Topics: Angiogenesis Inhibitors; Animals; Axitinib; Carcinoma, Renal Cell; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Imidazoles; Indazoles; Indoles; Kidney Neoplasms; Mice; Mice, Nude; Neovascularization, Pathologic; Pyrroles; Random Allocation; Sunitinib; Xenograft Model Antitumor Assays	2016
Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease. European journal of pharmacology, 2016, Nov-15, Volume: 791 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Indazoles; Male; Mesencephalon; Mice; Neostriatum; Parkinson Disease; Phosphorylation; Substantia Nigra; tau Proteins; Tyrosine 3-Monooxygenase	2016
Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression. ACS chemical neuroscience, 2016, 12-21, Volume: 7, Issue:12 Topics: Administration, Oral; Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Gerbillinae; Humans; Indazoles; Mice; Molecular Structure; Neurokinin-1 Receptor Antagonists; Rats; Receptors, Neurokinin-1; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship; Transcriptional Regulator ERG	2016
Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts. Oncotarget, 2017, Jan-10, Volume: 8, Issue:2 Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Immunohistochemistry; Indazoles; Indoles; Mice; Neoplastic Stem Cells; Pancreatic Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays	2017
Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis. Oncotarget, 2017, Jan-10, Volume: 8, Issue:2 Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Mice; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrimidines; Signal Transduction; Sulfonamides; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2017
Folate-Hapten-Mediated Immunotherapy Synergizes with Vascular Endothelial Growth Factor Receptor Inhibitors in Treating Murine Models of Cancer. Molecular cancer therapeutics, 2017, Volume: 16, Issue:3 Topics: Animals; Antineoplastic Agents; Axitinib; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Female; Folic Acid; Haptens; Humans; Imidazoles; Immunotherapy; Indazoles; Mice; Neoplasms; Neovascularization, Pathologic; Protein Kinase Inhibitors; Receptors, Vascular Endothelial Growth Factor; T-Lymphocyte Subsets; Tumor Burden; Xenograft Model Antitumor Assays	2017
Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway. Molecules (Basel, Switzerland), 2016, Dec-21, Volume: 21, Issue:12 Topics: Angiogenesis Inhibitors; Animals; Cell Hypoxia; Cell Line; Cobalt; Diabetic Retinopathy; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation; Glucosides; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Indazoles; Ligustrum; Plant Extracts; Pyrans; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Pigment Epithelium; Signal Transduction; Vascular Endothelial Growth Factor A	2016
Relationship between PDK1 and contraction in carotid arteries in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model. Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:4 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Phosphoinositide-Dependent Protein Kinases; Animals; Carotid Arteries; Chronic Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Pyrimidines; Rats; Rats, Wistar; Serotonin; Signal Transduction; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents	2017
1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine. Anesthesiology, 2017, Volume: 126, Issue:5 Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Gastrointestinal Diseases; Indazoles; Male; Mice; Mice, Inbred C57BL; Morphine; Receptors, Opioid	2017
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas. Nature medicine, 2017, Volume: 23, Issue:4 Topics: Animals; Benzamides; Biphenyl Compounds; Brain Neoplasms; Brain Stem Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Chromatography, Liquid; CRISPR-Cas Systems; Cyclin-Dependent Kinase Inhibitor p16; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Gene Knockout Techniques; Glioblastoma; Glioma; Histones; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Indazoles; Mice; Mice, SCID; Molecular Targeted Therapy; Morpholines; Mutation; Neoplasm Transplantation; Neural Stem Cells; Polycomb Repressive Complex 2; Pyridones; Tandem Mass Spectrometry; Tumor Suppressor Protein p14ARF	2017
Fish oil prevents rodent anxious states comorbid with diabetes: A putative involvement of nitric oxide modulation. Behavioural brain research, 2017, 05-30, Volume: 326 Topics: Amygdala; Animals; Anxiety; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Inhibitors; Fish Oils; Hippocampus; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Periaqueductal Gray; Rats; Rats, Wistar; Streptozocin	2017
7-nitroindazole, nitric oxide synthase inhibitor, attenuates physical dependence on butorphanol in rat. Synapse (New York, N.Y.), 2008, Volume: 62, Issue:8 Topics: Analgesics, Opioid; Animals; Brain; Butorphanol; Cell Count; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Male; Narcotic Antagonists; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	2008
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. American journal of physiology. Renal physiology, 2008, Volume: 295, Issue:4 Topics: Aging; Animals; Disease Models, Animal; Enzyme Activators; Epithelial Cells; Female; Fibrosis; Gene Deletion; Gene Expression; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Kidney Diseases; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Transfection; Up-Regulation; Von Hippel-Lindau Tumor Suppressor Protein	2008
Thrombin up-regulates vascular endothelial growth factor in experimental gliomas. Neurological research, 2009, Volume: 31, Issue:7 Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Glioma; Hemostatics; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Rats; Rats, Inbred F344; Signal Transduction; Thrombin; Time Factors; Up-Regulation; Vascular Endothelial Growth Factor A	2009
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia. Pain, 2009, Volume: 142, Issue:1-2 Topics: Analgesics; Animals; Body Temperature; Bone Neoplasms; Calcium; Disease Models, Animal; Drug Interactions; Fever; Indazoles; Inflammation; Male; Mice; Mice, Inbred C3H; Motor Activity; Osteoarthritis; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea	2009
Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase. Neuroscience, 2009, Mar-17, Volume: 159, Issue:2 Topics: Animals; Convulsants; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gene Expression Regulation; Imidazoles; Indazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Pentylenetetrazole; Quinoxalines; Seizures	2009
Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease. Neuroscience, 2009, Mar-31, Volume: 159, Issue:3 Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Indazoles; Levodopa; Male; Motor Activity; Nitric Oxide Synthase; Nitroarginine; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Substantia Nigra	2009
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. Journal of lipid research, 2009, Volume: 50, Issue:12 Topics: Animals; Atherosclerosis; Caco-2 Cells; Cholesterol, LDL; Cricetinae; Disease Models, Animal; Humans; Indazoles; Ligands; Lipid Metabolism; Liver; Liver X Receptors; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orphan Nuclear Receptors	2009
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects. Journal of cardiovascular pharmacology and therapeutics, 2009, Volume: 14, Issue:2 Topics: Animals; Apoptosis; Carotid Artery Injuries; Cell Proliferation; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Guanylate Cyclase; Indazoles; Male; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Sprague-Dawley	2009
Suppression and regression of choroidal neovascularization by the multitargeted kinase inhibitor pazopanib. Archives of ophthalmology (Chicago, Ill. : 1960), 2009, Volume: 127, Issue:4 Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Biological Availability; Choroid; Choroidal Neovascularization; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Indazoles; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Pyrimidines; Retina; Sulfonamides; Tissue Distribution	2009
The dynamic detection of NO during stroke and reperfusion in vivo. Brain injury, 2009, Volume: 23, Issue:5 Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Imines; Indazoles; Infusions, Intravenous; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke	2009
In the rat maximal dentate activation model of partial complex epilepsy, the anticonvulsant activity of levetiracetam is modulated by nitric oxide-active drugs. Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:7 Topics: Animals; Anticonvulsants; Arginine; Dentate Gyrus; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Enzyme Inhibitors; Epilepsy, Complex Partial; Indazoles; Levetiracetam; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Piracetam; Rats; Rats, Wistar	2009
The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovascular research, 2009, Dec-01, Volume: 84, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Apolipoproteins E; Carotid Arteries; Carotid Artery Injuries; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Female; Hyperlipidemias; Indazoles; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Propionates; Rats; Rats, Wistar	2009
Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins. Arthritis and rheumatism, 2009, Volume: 60, Issue:8 Topics: Alphavirus; Alphavirus Infections; Animals; Antirheumatic Agents; Arthritis, Experimental; Cell Line; Disease Models, Animal; Down-Regulation; Humans; Indazoles; Macrophages; Mice; Mice, Inbred C57BL; Monocyte Chemoattractant Proteins; Muscle, Skeletal; Myositis; Propionates; RNA, Messenger	2009
The chemokine monocyte chemoattractant protein-1 contributes to renal dysfunction in swine renovascular hypertension. Journal of hypertension, 2009, Volume: 27, Issue:10 Topics: Animals; Chemokine CCL2; Disease Models, Animal; Fibrosis; Hypertension, Renovascular; Indazoles; Kidney Tubules; NADPH Oxidases; Nephritis; NF-kappa B; Propionates; Receptors, CCR2; Renal Artery Obstruction; Renal Circulation; Sus scrofa; Up-Regulation; Urothelium	2009
Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IkappaB kinase-2 (IKK-2) target safety and efficacy. Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:3 Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Female; I-kappa B Kinase; Indazoles; Isonicotinic Acids; Male; Models, Biological; Rats; Rats, Inbred Lew; Rats, Wistar; Tumor Necrosis Factor-alpha	2010
Putative antinociceptive action of nitric oxide in the caudal part of the spinal trigeminal nucleus during chronic carrageenan-induced arthritis in the rat temporomandibular joint. Brain research, 2009, Dec-11, Volume: 1302 Topics: Animals; Arthralgia; Arthritis, Experimental; Carrageenan; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Inflammation Mediators; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nociceptors; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Wistar; RNA, Messenger; Temporomandibular Joint Disorders; Trigeminal Caudal Nucleus	2009
Axitinib--a selective inhibitor of the vascular endothelial growth factor (VEGF) receptor. Targeted oncology, 2009, Volume: 4, Issue:4 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Axitinib; Disease Models, Animal; Drug Delivery Systems; Imidazoles; Indazoles; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2009
Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760 The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2 Topics: Animals; Atrial Natriuretic Factor; Cardiotonic Agents; Caveolin 3; Disease Models, Animal; Dose-Response Relationship, Drug; Dystrophin; Glycoproteins; Heart; Heart Failure; Hypertrophy, Left Ventricular; Indazoles; Male; Mice; Mice, Inbred Strains; Myocardium; Nitric Oxide Synthase Type III; Spectrin	2010
Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. Molecular pharmacology, 2010, Volume: 77, Issue:3 Topics: Animals; Animals, Newborn; Disease Models, Animal; Indazoles; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxygen; Retinal Diseases; Retinal Neovascularization	2010
Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity. Seizure, 2010, Volume: 19, Issue:2 Topics: Analysis of Variance; Animals; Antioxidants; Arginine; Ascorbic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electroencephalography; Enzyme Inhibitors; Epilepsy; Free Radical Scavengers; Indazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Penicillins; Rats; Rats, Wistar	2010
Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia. Journal of neuroscience research, 2010, Volume: 88, Issue:9 Topics: 2-Methoxyestradiol; Acute Disease; Animals; Brain; Brain Ischemia; Central Nervous System Agents; Disease Models, Animal; Estradiol; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Infarction, Middle Cerebral Artery; Intracranial Hemorrhages; Male; Rats; Rats, Sprague-Dawley; Time Factors	2010
Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Feb-17, Volume: 30, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety Disorders; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exploratory Behavior; Feeding Behavior; Fluoxetine; Gene Expression Regulation, Enzymologic; Hippocampus; Indazoles; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type I; Phosphorylation; Piperazines; Reaction Time; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors	2010
Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice. Epilepsy research, 2010, Volume: 89, Issue:2-3 Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indazoles; Injections, Intraperitoneal; Lithium Chloride; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Phosphodiesterase Inhibitors; Piperazines; Purines; Seizures; Sildenafil Citrate; Sulfones; Treatment Outcome	2010
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models. Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Jul-15, Volume: 16, Issue:14 Topics: Animals; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Female; Gene Expression Profiling; Humans; Indazoles; Mammary Neoplasms, Experimental; Mice; Mutation; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Predictive Value of Tests; Receptor, ErbB-2; Sensitivity and Specificity; Sulfonamides; Xenograft Model Antitumor Assays	2010
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. Epilepsy & behavior : E&B, 2010, Volume: 18, Issue:3 Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Indazoles; Lithium Chloride; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Seizures; Signal Transduction	2010
PIKing the right patient. Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Jul-15, Volume: 16, Issue:14 Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Disease Models, Animal; Female; Gene Expression Profiling; Humans; Indazoles; Mice; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Receptor, ErbB-2; Sulfonamides; Transcription Factors	2010
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis. Oral diseases, 2010, Volume: 16, Issue:8 Topics: Adenine; Amylases; Animals; Calcium; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Guanidines; Indazoles; Indomethacin; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Organ Size; Ornithine; Parotid Gland; Periodontitis; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salivary Proteins and Peptides; Thiazoles	2010
N-aryl pyrazoles, indazoles and azaindazoles as antagonists of CC chemokine receptor 1: patent cooperation treaty applications WO2010/036632, WO2009/134666 and WO2009/137338. Expert opinion on therapeutic patents, 2010, Volume: 20, Issue:11 Topics: Animals; Arthritis, Rheumatoid; Calcium; Disease Models, Animal; Humans; Indazoles; Inflammation; Leukocytes; Multiple Sclerosis; Patents as Topic; Pyrazoles; Receptors, CCR1; Structure-Activity Relationship	2010
Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis. Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Jan-01, Volume: 17, Issue:1 Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Indazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Proto-Oncogene Proteins B-raf; Pyrimidines; Receptor, ErbB-2; Signal Transduction; Sulfonamides; Xenograft Model Antitumor Assays	2011
Lack of tolerance for the anti-dyskinetic effects of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2010, Volume: 43, Issue:11 Topics: Animals; Anti-Dyskinesia Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Indazoles; Levodopa; Male; Nitric Oxide Synthase; Rats; Rats, Wistar; Substantia Nigra	2010
A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord. Glia, 2011, Volume: 59, Issue:2 Topics: Adenosine Triphosphate; Animals; Cell Movement; Cerebral Cortex; Cinnamates; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hyperalgesia; Indazoles; Intramolecular Oxidoreductases; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Microglia; Neuralgia; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Prostaglandin-E Synthases; S-Nitrosoglutathione; Spinal Cord; Spinal Nerves	2011
Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats. Neurogastroenterology and motility, 2011, Volume: 23, Issue:7 Topics: Animals; Animals, Newborn; Colon; Colonic Diseases; Disease Models, Animal; Electromyography; Gastrointestinal Motility; Hyperalgesia; Indazoles; Irritable Bowel Syndrome; Male; Maternal Behavior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; Stress, Psychological	2011
7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model. Pharmacological reports : PR, 2011, Volume: 63, Issue:1 Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Electroshock; Enzyme Inhibitors; gamma-Aminobutyric Acid; Indazoles; Male; Mice; Neuroprotective Agents; Nitroarginine; Pregabalin; Seizures; Toxicity Tests, Acute	2011
Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models. Progress in neuro-psychopharmacology & biological psychiatry, 2011, Aug-15, Volume: 35, Issue:7 Topics: Animals; Antipsychotic Agents; Apomorphine; Arginine; Catalepsy; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flavonoids; Indazoles; Male; Mice; Motor Activity; Nitric Oxide; Phytotherapy; Plant Leaves; Plant Preparations; Protein Kinase C; Psychotic Disorders; Rats; Rats, Wistar; Stereotyped Behavior; Syzygium; Tamoxifen	2011
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorganic & medicinal chemistry, 2011, Jul-15, Volume: 19, Issue:14 Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; fms-Like Tyrosine Kinase 3; Humans; Indazoles; Mice; Molecular Structure; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Sorafenib; Stereoisomerism; Structure-Activity Relationship; Sulfonamides	2011
Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test. Behavioural brain research, 2011, Nov-20, Volume: 225, Issue:1 Topics: Animals; Antidepressive Agents; Arginine; Ascorbic Acid; Cyclic GMP; Depression; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Exploratory Behavior; Female; Hindlimb Suspension; Indazoles; Mice; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Piperazines; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones	2011
Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening. Shock (Augusta, Ga.), 2012, Volume: 37, Issue:1 Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Indazoles; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Proteins; Muscle Proteins; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Shock, Septic	2012
A novel multi-targeted tyrosine kinase inhibitor, linifanib (ABT-869), produces functional and structural changes in tumor vasculature in an orthotopic rat glioma model. Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:4 Topics: Animals; Brain Neoplasms; Cell Growth Processes; Disease Models, Animal; Female; Glioma; Immunohistochemistry; Indazoles; Magnetic Resonance Angiography; Neovascularization, Pathologic; Phenylurea Compounds; Protein Kinase Inhibitors; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases; Xenograft Model Antitumor Assays	2012
Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke. PloS one, 2011, Volume: 6, Issue:11 Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Male; Neurons; Permeability; Prognosis; Rats; Rats, Sprague-Dawley; Stroke; Survival Rate; Vascular Endothelial Growth Factor A	2011
Changes in hippocampal gene expression by 7-nitroindazole in rats submitted to forced swimming stress. Genes, brain, and behavior, 2012, Volume: 11, Issue:3 Topics: Animals; Depressive Disorder, Major; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Imipramine; Indazoles; Male; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Stress, Psychological; Swimming	2012
Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma. Anticancer research, 2012, Volume: 32, Issue:2 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Enzyme Inhibitors; Female; Head and Neck Neoplasms; Indazoles; Longitudinal Studies; Lymphoma, B-Cell; Lymphoma, Follicular; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; Sulfonamides	2012
Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats. Acta pharmacologica Sinica, 2012, Volume: 33, Issue:5 Topics: Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Caspase 3; Cytoprotection; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Indazoles; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Intestines; Lung; Lung Injury; Male; Malondialdehyde; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Pulmonary Edema; Rats; Rats, Wistar; Shock, Hemorrhagic; Time Factors; Tumor Necrosis Factor-alpha	2012
In vivo participation of nitric oxide in hyperproliferative epidermal phenomena in mice. European journal of pharmacology, 2012, Jul-15, Volume: 687, Issue:1-3 Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents; Cell Proliferation; Croton Oil; Dermatitis, Contact; Dexamethasone; Disease Models, Animal; Enzyme Inhibitors; Epidermis; Guanidines; Indazoles; Keratinocytes; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitroprusside; Peroxidase	2012
Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A. Cancer discovery, 2012, Volume: 2, Issue:4 Topics: AMP-Activated Protein Kinases; Animals; Axitinib; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Synergism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indazoles; Melanoma; Metformin; Mice; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Ribosomal Protein S6 Kinases; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2012
Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2. Bioorganic & medicinal chemistry letters, 2012, Jul-01, Volume: 22, Issue:13 Topics: Animals; Binding Sites; Casein Kinase II; Computer Simulation; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Indazoles; Injections, Intraperitoneal; Nephritis; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrazines; Rats; Structure-Activity Relationship	2012
NESS038C6, a novel selective CB1 antagonist agent with anti-obesity activity and improved molecular profile. Behavioural brain research, 2012, Oct-01, Volume: 234, Issue:2 Topics: Analysis of Variance; Animals; Anti-Obesity Agents; Blood Glucose; Body Mass Index; Body Weight; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Cholesterol; Dietary Fats; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Hypothalamus; Indazoles; Intra-Abdominal Fat; Liver; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin Plasma Membrane Transport Proteins; Thiophenes; Transaminases; Triglycerides	2012
7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease. Neuropharmacology, 2012, Volume: 63, Issue:7 Topics: Animals; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; Indazoles; Male; Neostriatum; Neurons; Nitric Oxide Synthase Type I; Oxidopamine; Parkinson Disease, Secondary; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction	2012
The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat. Behavioural brain research, 2012, Dec-01, Volume: 235, Issue:2 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Indazoles; Male; Maze Learning; NADP; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Sprague-Dawley; Reaction Time; Restraint, Physical	2012
Antiangiogenic effects of axitinib, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, on laser-induced choroidal neovascularization in mice. Current eye research, 2013, Volume: 38, Issue:1 Topics: Animals; Axitinib; Choroid; Choroidal Neovascularization; Disease Models, Animal; Imidazoles; Indazoles; Laser Coagulation; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Protein Kinase Inhibitors; Treatment Outcome; Vascular Endothelial Growth Factor Receptor-1	2013
A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Annals of the rheumatic diseases, 2013, Volume: 72, Issue:5 Topics: Animals; Antirheumatic Agents; Cartilage, Articular; Cell Differentiation; Chondrogenesis; Core Binding Factor Alpha 2 Subunit; Disease Models, Animal; Drug Design; Gene Expression; Heterocyclic Compounds, 4 or More Rings; Indazoles; Injections, Intra-Articular; Knee Joint; Male; Mice; Osteoarthritis, Knee; RNA, Messenger	2013
Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation. Journal of neuroimmunology, 2013, Jan-15, Volume: 254, Issue:1-2 Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Brain Edema; Brain Infarction; CD11b Antigen; Cell Line, Transformed; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hydrazines; Indazoles; Infarction, Middle Cerebral Artery; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Microglia; Nervous System Diseases; NF-kappa B; Psychomotor Performance; Signal Transduction; Time Factors	2013
Anticonvulsant action of indazole. Epilepsy research, 2013, Volume: 104, Issue:3 Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Indazoles; Male; Mice; Pentylenetetrazole; Phenytoin; Seizures; Strychnine	2013
The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats. European journal of pharmacology, 2013, Jan-15, Volume: 699, Issue:1-3 Topics: Animals; Arterial Pressure; Disease Models, Animal; DNA-Binding Proteins; Enzyme Activators; Gene Expression Regulation; Heart Rate; Heat Shock Transcription Factors; Heat Stroke; HSP70 Heat-Shock Proteins; Indazoles; Kidney; Liver; Male; Quercetin; Rats; Rats, Sprague-Dawley; Survival Rate; Transcription Factors	2013
3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, reduces brain edema through the inhibition of enhanced blood-brain barrier perme The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:3 Topics: Animals; Blood-Brain Barrier; Brain Edema; Calmodulin; Cell Membrane Permeability; Disease Models, Animal; Endothelium, Vascular; Indazoles; Ischemic Attack, Transient; Male; Rats; Rats, Wistar; Trifluoperazine; Water	2003
Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behavioural brain research, 2003, Mar-18, Volume: 140, Issue:1-2 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Arginine; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exploratory Behavior; Imidazoles; Imipramine; Immobilization; Indazoles; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Reaction Time; Swimming	2003
Is HIF-1 alpha a valid therapeutic target? Journal of the National Cancer Institute, 2003, Apr-02, Volume: 95, Issue:7 Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Disease Models, Animal; Endothelial Growth Factors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Neoplasms; Neovascularization, Pathologic; Repressor Proteins; Trans-Activators; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model. American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 285, Issue:2 Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines; Indazoles; Lung Diseases; Nitric Oxide Synthase; omega-N-Methylarginine; Pneumonia, Bacterial; Sheep, Domestic; Smoke	2003
The neuroprotective effect of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, in transient forebrain ischemia. Neuroscience, 2003, Volume: 121, Issue:2 Topics: Animals; Blotting, Western; Brain Ischemia; Calmodulin; Carotid Artery, Internal, Dissection; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme Inhibitors; Gerbillinae; Hippocampus; Immunohistochemistry; Indazoles; Ischemic Attack, Transient; Male; Microdialysis; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Reperfusion; Time Factors; Tyrosine	2003
DY-9760e, a novel calmodulin antagonist, reduces infarction after permanent focal cerebral ischemia in rats. Pharmacology, 2004, Volume: 71, Issue:1 Topics: Animals; Brain Ischemia; Calmodulin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Indazoles; Infarction, Middle Cerebral Artery; Infusions, Intravenous; Japan; Male; Middle Cerebral Artery; Neuroprotective Agents; Rats; Rats, Inbred F344; Recovery of Function; Time Factors	2004
Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches. Neurobiology of disease, 2005, Volume: 18, Issue:2 Topics: Animals; Antipyrine; Brain; Cerebral Cortex; Cerebrovascular Circulation; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Functional Laterality; Hippocampus; Indazoles; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Status Epilepticus	2005
Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis. American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 288, Issue:6 Topics: Acute Disease; Animals; Ceruletide; Chemokine CCL2; Disease Models, Animal; Indazoles; Inflammation; Mice; Necrosis; Pancreas; Pancreatitis; Propionates	2005
Combined treatment of ascorbic acid or alpha-tocopherol with dopamine receptor antagonist or nitric oxide synthase inhibitor potentiates cataleptic effect in mice. Psychopharmacology, 2005, Volume: 181, Issue:1 Topics: alpha-Tocopherol; Animals; Ascorbic Acid; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Enzyme Inhibitors; Haloperidol; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Time Factors; Vitamins	2005
A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models. Thrombosis and haemostasis, 2005, Volume: 93, Issue:5 Topics: Animals; Blotting, Western; Cyclic GMP; Cytokines; Disease Models, Animal; DNA; Endotoxemia; Humans; Immunohistochemistry; Indazoles; Leukocytes; Leukocytes, Mononuclear; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Shock, Septic; Time Factors; Up-Regulation	2005
Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma. Human psychopharmacology, 2005, Volume: 20, Issue:5 Topics: Animals; Cyclic GMP; Disease Models, Animal; Hippocampus; Indazoles; Male; NF-kappa B; Nitric Oxide; Piperazines; Proline; Purines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sildenafil Citrate; Stress Disorders, Post-Traumatic; Sulfones; Thiocarbamates	2005
Sex differences in cell death. Annals of neurology, 2005, Volume: 58, Issue:2 Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; DNA-Binding Proteins; Drug Interactions; Female; Genotype; Glucose; High Mobility Group Proteins; Hippocampus; Hypoxia; Indazoles; Male; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide; Organ Culture Techniques; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Characteristics; SOXB1 Transcription Factors; Stroke; Superoxide Dismutase; Time Factors; Transcription Factors	2005
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. Journal of medicinal chemistry, 2006, Jan-12, Volume: 49, Issue:1 Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Haplorhini; Head Movements; Humans; Indazoles; Lasers; Mice; Molecular Structure; Ocular Hypertension; Rabbits; Rats; Serotonin 5-HT2 Receptor Agonists	2006
3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydro-chloride 3.5 hydrate (DY-9760e) is neuroprotective in rat microsphere embolism: role of the cross-talk between calpain and caspase-3 thro The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:2 Topics: Animals; Brain Ischemia; Calcium-Binding Proteins; Calmodulin; Calpain; Caspase 3; Caspases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Indazoles; Intracranial Embolism; Male; Microspheres; Neurons; Neuroprotective Agents; Protein Binding; Rats; Rats, Wistar	2006
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. Neuroscience letters, 2006, Jun-19, Volume: 401, Issue:1-2 Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Brain; Brain Chemistry; Caspase 9; Caspases; Cerebral Cortex; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hypoxia, Brain; Indazoles; Nerve Degeneration; Nitric Oxide; Nitric Oxide Synthase Type I; Phosphocreatine; Signal Transduction; Sus scrofa; Up-Regulation	2006
[Effects of phosphatidylcholine pretreatment during acute experimental biliary reflux]. Magyar sebeszet, 2005, Volume: 58, Issue:6 Topics: Adenosine Triphosphate; Animals; Blood Flow Velocity; Cell Degranulation; Disease Models, Animal; Dogs; Enzyme Inhibitors; Erythrocytes; Esophagus; Gastroesophageal Reflux; Indazoles; Leukocytes; Mast Cells; Microcirculation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Phosphatidylcholines	2005
Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets. Neuroscience, 2006, Jul-07, Volume: 140, Issue:3 Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cell Death; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hypoxia, Brain; Indazoles; Nerve Degeneration; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phosphocreatine; Sus scrofa; Up-Regulation	2006
Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neuroscience, 2006, Aug-25, Volume: 141, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Cell Count; Cyclic GMP; Disease Models, Animal; Drug Administration Schedule; Gene Expression Regulation; Guanylate Cyclase; Immunohistochemistry; Indazoles; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parkinsonian Disorders; Time Factors; Tyrosine 3-Monooxygenase	2006
Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety. European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3 Topics: Analysis of Variance; Animals; Anxiety; Benzopyrans; Biphenyl Compounds; Conflict, Psychological; Depressive Disorder; Disease Models, Animal; Hindlimb Suspension; Indazoles; Male; Mice; Mice, Inbred BALB C; Motor Activity; Naphthalenes; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Somatostatin; Swimming	2006
Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Aug-01, Volume: 12, Issue:15 Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Aryl Hydrocarbon Receptor Nuclear Translocator; Caspases; Cell Death; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose; Humans; Hypoxia; Indazoles; Mice; Mice, SCID; Phenylurea Compounds; Structure-Activity Relationship; Temozolomide; Transplantation, Heterologous; Xenograft Model Antitumor Assays	2006
Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke. Neuropharmacology, 2007, Volume: 52, Issue:2 Topics: Animals; Blood Pressure; Body Temperature; Brain Chemistry; Cerebrovascular Disorders; Disease Models, Animal; Enzyme Inhibitors; Heat Stroke; Hypothalamus; Immunohistochemistry; Indazoles; Intracranial Pressure; Neural Inhibition; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha	2007
Effects of acute hypobaric hypoxia on the nitric oxide system of the rat cerebral cortex: Protective role of nitric oxide inhibitors. Neuroscience, 2006, Oct-27, Volume: 142, Issue:3 Topics: Altitude; Analysis of Variance; Animals; Blotting, Western; Calcium; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Hypoxia; Immunohistochemistry; Indazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Tyrosine	2006
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Sep-13, Volume: 26, Issue:37 Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Calcium; Capsaicin; Cell Line; Cells, Cultured; Central Nervous System; Disease Models, Animal; Humans; Hyperalgesia; Indazoles; Inflammation Mediators; Injections, Spinal; Male; Nociceptors; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Sulfones; Treatment Outcome; TRPV Cation Channels; Urea	2006
7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study. Annals of the New York Academy of Sciences, 2006, Volume: 1089 Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Indazoles; Male; Microdialysis; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Parkinson Disease; Rats; Rats, Sprague-Dawley; Substantia Nigra	2006
Discovery of novel indazole-linked triazoles as antifungal agents. Bioorganic & medicinal chemistry letters, 2007, Jun-15, Volume: 17, Issue:12 Topics: Administration, Oral; Animals; Antifungal Agents; Aspergillus; Candida; Disease Models, Animal; Indazoles; Mice; Microbial Sensitivity Tests; Rats; Stereoisomerism; Triazoles	2007
[Effects of 7-nitroindazole on smoke inhalation pulmonary injury]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2007, Volume: 19, Issue:4 Topics: Acute Lung Injury; Animals; Disease Models, Animal; Indazoles; Lung; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Random Allocation; Rats; Rats, Sprague-Dawley; Smoke Inhalation Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2007
Ventilatory response to hypoxia during endotoxemia in young rats: role of nitric oxide. Pediatric research, 2007, Volume: 62, Issue:2 Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Female; Hypoxia; Indazoles; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxygen Consumption; Pulmonary Ventilation; Rats; Rats, Wistar; Time Factors	2007
Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat. BMC neuroscience, 2007, Jul-03, Volume: 8 Topics: Animals; Anticonvulsants; Arginine; Brain; Dentate Gyrus; Disease Models, Animal; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Epilepsy, Complex Partial; Indazoles; Lamotrigine; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Triazines	2007
The role of nitric oxide in the anticonvulsant effects of pyridoxine on penicillin-induced epileptiform activity in rats. Epilepsy research, 2007, Volume: 76, Issue:1 Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Enzyme Inhibitors; Epilepsy; Indazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Penicillins; Pyridoxine; Rats; Rats, Wistar; Somatosensory Cortex; Time Factors	2007
Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease. Cell transplantation, 2007, Volume: 16, Issue:5 Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Choline; Disease Models, Animal; Female; Indazoles; Methamphetamine; NADPH Dehydrogenase; Neostriatum; Neurons; Nitric Oxide; Parkinson Disease; Pedunculopontine Tegmental Nucleus; Pregnancy; Rats; Rats, Sprague-Dawley; Rotation; Somatostatin; Time Factors; Tyrosine 3-Monooxygenase; Ventral Tegmental Area	2007
Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression. Journal of neurochemistry, 2007, Volume: 103, Issue:5 Topics: Animals; Brain Infarction; Cell Count; Cell Proliferation; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Indazoles; Infarction, Middle Cerebral Artery; Ischemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Up-Regulation	2007
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals. American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:2 Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Diuresis; Enzyme Inhibitors; Hydronephrosis; Hypertension; Indazoles; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride, Dietary; Ureteral Obstruction	2008
Bee venom injection produces a peripheral anti-inflammatory effect by activation of a nitric oxide-dependent spinocoeruleus pathway. Neuroscience letters, 2008, Jan-10, Volume: 430, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Bee Venoms; Disease Models, Animal; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Indazoles; Leukocytes; Locus Coeruleus; Male; Mice; Mice, Inbred ICR; Neural Pathways; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oncogene Proteins v-fos; Peripheral Nervous System Diseases; Spinal Cord; Tyrosine 3-Monooxygenase	2008
Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction. The European journal of neuroscience, 2008, Volume: 27, Issue:1 Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Aspartic Acid; Behavior, Animal; Cysteine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Transporter 1; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Hydroxamic Acids; In Vitro Techniques; Indazoles; Male; Mice; Mice, Inbred C57BL; Movement Disorders; MPTP Poisoning; Neuroprotective Agents; Oxidative Stress; Substantia Nigra	2008
Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Cytoprotection; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activators; Enzyme Inhibitors; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Gliosis; Homovanillic Acid; Indazoles; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Parkinsonian Disorders; Reactive Nitrogen Species; Reactive Oxygen Species; Tyrosine 3-Monooxygenase	2008
7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease. Experimental and clinical psychopharmacology, 2008, Volume: 16, Issue:2 Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Indazoles; Learning Disabilities; Male; Maze Learning; NADP; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spatial Behavior; Substantia Nigra	2008
Leukotriene receptor antagonism prevents lung protein leakage and hypoxaemia in a septic cat model. The European respiratory journal, 1994, Volume: 7, Issue:6 Topics: Analysis of Variance; Animals; Capillary Permeability; Cats; Diethylcarbamazine; Disease Models, Animal; Hypoxia; Indazoles; Leukotriene Antagonists; Leukotrienes; Lung; Organ Size; Shock, Septic	1994
Leukotriene D4 receptor antagonism reduces airway hyperresponsiveness in monkeys. Pulmonary pharmacology, 1994, Volume: 7, Issue:1 Topics: Animals; Antigens; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Eosinophils; Indazoles; Leukocyte Count; Leukocytes; Leukotriene Antagonists; Macaca fascicularis; Male; Membrane Proteins; Receptors, Leukotriene; SRS-A	1994
The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. Pulmonary pharmacology, 1994, Volume: 7, Issue:2 Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Humans; Hydroxyurea; Indazoles; Lipoxygenase Inhibitors; Male; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth; Pyrilamine; SRS-A; Trachea	1994
No NO prevents parkinsonism. Nature medicine, 1996, Volume: 2, Issue:9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Humans; Indazoles; Neurons; Nitric Oxide; Nitric Oxide Synthase; Papio; Parkinson Disease	1996
Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nature medicine, 1996, Volume: 2, Issue:9 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Homovanillic Acid; Hypokinesia; Indazoles; Male; Motor Activity; Neurologic Examination; Neurons; Nitric Oxide Synthase; Papio; Parkinson Disease, Secondary; Substantia Nigra; Videotape Recording	1996
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation. British journal of pharmacology, 1996, Volume: 119, Issue:1 Topics: Animals; Anticonvulsants; Arginine; Blood Pressure; Citrulline; Disease Models, Animal; Epilepsy; Female; Heart Rate; Indazoles; Male; Mice; Mice, Inbred DBA; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Noise; Rats; Rats, Inbred Strains; Reflex; Seizures	1996
Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia. European journal of pharmacology, 1996, Aug-29, Volume: 310, Issue:2-3 Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Gerbillinae; Indazoles; Male; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Quinoxalines	1996
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice. European journal of pharmacology, 1997, Feb-12, Volume: 320, Issue:2-3 Topics: Adenosine Diphosphate; Animals; Bleeding Time; Blood Coagulation; Blood Platelets; Disease Models, Animal; Enzyme Activation; Fibrinolytic Agents; Fluorescein; Fluoresceins; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Embolism; Serum Globulins; Solubility; Thrombosis	1997
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy. European journal of pharmacology, 1997, Apr-11, Volume: 324, Issue:1 Topics: Analysis of Variance; Animals; Blood Pressure; Citrulline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Guanidines; Heart Rate; Indazoles; Isoenzymes; Male; Morphine; Naloxone; Narcotic Antagonists; Nitric Oxide Synthase; Rats; Rats, Inbred F344; Substance Withdrawal Syndrome; Thiourea	1997
Cerebrovascular effects of nitric oxide manipulation in spontaneously hypertensive rats. British journal of pharmacology, 1997, Volume: 121, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Blood Pressure; Cerebrovascular Circulation; Disease Models, Animal; Hypertension; Indazoles; Infusions, Intravenous; Injections, Intravenous; Isotope Labeling; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents	1997
7-Nitroindazole inhibits pial arteriolar vasodilation in a rat model of pneumococcal meningitis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:9 Topics: Animals; Arteries; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Male; Meningitis, Pneumococcal; Nitric Oxide Synthase; Rats; Rats, Wistar; Vasodilation	1997
Role of platelet activating factor, leukotrienes and polymorphs in the FMLP induced increase in microvascular leakage in rabbit trachea. Respirology (Carlton, Vic.), 1997, Volume: 2, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkylating Agents; Animals; Azepines; Bronchitis; Capillary Permeability; Coloring Agents; Disease Models, Animal; Drug Interactions; Evans Blue; Indazoles; Leukotrienes; Male; Mechlorethamine; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Rabbits; Reference Values; Trachea; Triazoles; Vasoconstrictor Agents	1997
The selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, reduces the delayed neuronal damage due to forebrain ischemia in rats. Stroke, 1998, Volume: 29, Issue:6 Topics: Animals; Body Temperature; Cell Count; Disease Models, Animal; Enzyme Inhibitors; Hippocampus; Indazoles; Ischemic Attack, Transient; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Prosencephalon; Rats; Rats, Wistar	1998
Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse. Journal of the neurological sciences, 1998, Sep-18, Volume: 160, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hand Strength; Indazoles; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Motor Neurons; Muscle Denervation; Muscle, Skeletal; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Organ Size; Vacuoles	1998
The protective effect of riluzole in the MPTP model of Parkinson's disease in mice is not due to a decrease in MPP(+) accumulation. Neuropharmacology, 2000, Apr-03, Volume: 39, Issue:6 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Indazoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease, Secondary; Riluzole	2000
Prevention of dopaminergic neurotoxicity by targeting nitric oxide and peroxynitrite: implications for the prevention of methamphetamine-induced neurotoxic damage. Annals of the New York Academy of Sciences, 2000, Volume: 914 Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Cyclic N-Oxides; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Electrochemistry; Free Radical Scavengers; Homovanillic Acid; Imidazoles; Indazoles; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Models, Biological; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide; Peroxynitrous Acid; Tyrosine	2000
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:10 Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; Epilepsies, Myoclonic; Ethosuximide; Indazoles; Male; Mice; Motor Skills; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Pentylenetetrazole; Seizures	2000
Changes in nitric oxide synthesis and epileptic activity in the contralateral hippocampus of rats following intrahippocampal kainate injection. Epilepsia, 2001, Volume: 42, Issue:1 Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Functional Laterality; Hippocampus; Indazoles; Injections, Intraperitoneal; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar	2001
NO-independent regulatory site on soluble guanylate cyclase. Nature, 2001, Mar-08, Volume: 410, Issue:6825 Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cyclic N-Oxides; Cysteine; Disease Models, Animal; Enzyme Activation; Female; Guanylate Cyclase; Heme; Humans; Imidazoles; In Vitro Techniques; Indazoles; Molecular Sequence Data; Nitric Oxide; Photoaffinity Labels; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Rats; Solubility	2001
Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat. Journal of neurochemistry, 2001, Volume: 76, Issue:6 Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Indazoles; Ischemic Attack, Transient; Male; Middle Cerebral Artery; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Reference Values; Superoxides; Tamoxifen; Tyrosine	2001
Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis. Neuroscience, 2001, Volume: 104, Issue:4 Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Enzyme Activators; Excitatory Amino Acid Agonists; Glutamic Acid; Guanylate Cyclase; Hepatic Encephalopathy; Hyperammonemia; Immunoblotting; Indazoles; Lymphocytes; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine; Synaptic Transmission	2001
7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. Biology of the neonate, 2001, Volume: 80, Issue:1 Topics: Animals; Animals, Newborn; Blood Glucose; Brain Diseases; Cerebral Cortex; Cerebrospinal Fluid; Disease Models, Animal; Enzyme Inhibitors; Glucose; Guanidines; Indazoles; Inflammation; Lactic Acid; Leukocytosis; Lipid Peroxidation; Meningitis, Escherichia coli; Nitric Oxide Synthase; Swine; Tumor Necrosis Factor-alpha	2001
Post-ischemic administration of DY-9760e, a novel calmodulin antagonist, reduced infarct volume in the permanent focal ischemia model of spontaneously hypertensive rat. Neurological research, 2001, Volume: 23, Issue:6 Topics: Animals; Brain Infarction; Brain Ischemia; Calcium; Calmodulin; Cerebral Cortex; Cerebrovascular Circulation; Disease Models, Animal; Glutamic Acid; Indazoles; Male; Neostriatum; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Inbred SHR	2001
6-Sulfanilamidoindazole arthritis: influence of alloxan diabetes, phenylbutazone and D-penicillamine on inflammatory size, sulfhydryl groups, diphenylamine reaction and enzymes of the serum. Life sciences, 1975, Mar-01, Volume: 16, Issue:5 Topics: Alkaline Phosphatase; Animals; Arthritis; Blood Glucose; Diabetes Mellitus, Experimental; Diphenylamine; Disease Models, Animal; Indazoles; Male; Muramidase; Penicillamine; Phenylbutazone; Pyrazoles; Rats; Sulfanilamides; Sulfhydryl Compounds	1975
Animal models for the study of atypical anti-inflammatory agents. Agents and actions, 1986, Volume: 17, Issue:3-4 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzydamine; Cortisone; Disease Models, Animal; Humans; Indazoles; Inflammation	1986