Page last updated: 2024-08-21

indazoles and Asthma

indazoles has been researched along with Asthma in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19902 (14.29)18.7374
1990's4 (28.57)18.2507
2000's0 (0.00)29.6817
2010's8 (57.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Begg, M; Cahn, A; Cui, Y; Hamblin, JN; Hessel, EM; Hogg, A; Khindri, S; Kornmann, O; Leemereise, C; Ludwig-Sengpiel, A; Montembault, M; Robertson, J; Wajdner, H; Yang, S1
Norman, P1
Carreño, C; De Alba, J; Domènech, A; Eichhorn, P; Fernández, JC; Maldonado, M; Miralpeix, M; Orellana, A; Otal, R; Prats, N; Ramis, I; Vidal, B1
Amour, A; Baldwin, IR; Cooper, AW; Deakin, AM; Down, K; Felton, LM; Guntrip, SB; Hamblin, JN; Hardy, C; Harrison, ZA; Jones, KL; Jones, P; Keeling, SE; Le, J; Livia, S; Lucas, F; Lunniss, CJ; Parr, NJ; Robinson, E; Rowland, P; Smith, S; Thomas, DA; Vitulli, G; Washio, Y1
Liu, C; Wang, X; Wu, L; Zhu, S1
Amilon, C; Bäckman, P; Cleton, A; Hamrén, UW; Jorup, C; Kloft, C; Melin, J; Olsson, B; Prothon, S1
Bonar, SL; Brustkern, SJ; Chen, NX; Christine, L; Heier, RF; Hu, Y; Huang, HC; Kishore, NN; Kurumbail, RG; Lennon, PJ; Li, X; Mathialagan, S; Poda, GI; Reding, MT; Selness, SR; Sommers, CD; Venkatraman, N; Wolfson, SG; Xie, J1
Akong-Moore, K; Broide, DH; Cho, JY; Cowburn, AS; Crotty Alexander, LE; Feldstein, S; Isaacs, H; Johansson, P; Johnson, RS; McEachern, EK; Nguyen, A; Nicatia, S; Nizet, V; Olson, J1
Brink, C; Gascard, JP; Gorenne, I; Labat, C1
Callens, E; Djebbar, R; Ruff, F; Santais, MC1
Giovanazzi, S; Mezzetti, M; Nicosia, S; Rovati, GE1
Björck, T; Dahlén, B; Dahlén, SE; Harada, Y; Hedqvist, P; Johansson, G; Rodriguez, L; Zetterström, O1
Bernstein, PR; Handley, DA; Harris, KE; Krell, RD; Patterson, R; Saunders, RN1
Cloud, ML; Fleisch, JH; Marshall, WS1

Reviews

2 review(s) available for indazoles and Asthma

ArticleYear
[Potential importance of antileukotrienes in the treatment of asthma and other inflammatory diseases: apropos of a new pharmacological class].
    La Revue de medecine interne, 1998, Volume: 19, Issue:2

    Topics: Acetophenones; Adult; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Asthma; Bronchoconstriction; Child; Clinical Trials as Topic; Crohn Disease; Cystic Fibrosis; Haplorhini; Humans; Hydroxyurea; Indazoles; Indoles; Leukotriene Antagonists; Leukotrienes; Lipoxygenase Inhibitors; Phenylcarbamates; Psoriasis; Randomized Controlled Trials as Topic; Respiratory Distress Syndrome; Sulfonamides; Tetrazoles; Tosyl Compounds

1998
A brief review of preclinical and clinical studies with LY171883 and some comments on newer cysteinyl leukotriene receptor antagonists.
    Annals of the New York Academy of Sciences, 1988, Volume: 524

    Topics: Acetophenones; Animals; Asthma; Azoles; Bronchi; Chromones; Dicarboxylic Acids; Drug Evaluation; Drug Evaluation, Preclinical; Guinea Pigs; Haplorhini; Humans; Indazoles; Leukotriene E4; Receptors, Leukotriene; Receptors, Prostaglandin; SRS-A; Structure-Activity Relationship; Tetrazoles

1988

Trials

2 trial(s) available for indazoles and Asthma

ArticleYear
A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:3

    Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Asthma; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Phosphatidylinositol 3-Kinases; Piperazines; Vital Capacity; Young Adult

2018
Pharmacokinetics of the Inhaled Selective Glucocorticoid Receptor Modulator AZD5423 Following Inhalation Using Different Devices.
    The AAPS journal, 2017, Volume: 19, Issue:3

    Topics: Acetamides; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Dry Powder Inhalers; Humans; Indazoles; Male; Young Adult

2017

Other Studies

10 other study(ies) available for indazoles and Asthma

ArticleYear
Crystalline forms of 2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-methoxyphenyl)-2-propanyl]acetamide (AZD-5423).
    Expert opinion on therapeutic patents, 2013, Volume: 23, Issue:9

    Topics: Acetamides; Administration, Inhalation; Animals; Asthma; Crystallization; Humans; Indazoles; Patents as Topic; Pulmonary Disease, Chronic Obstructive; Receptors, Glucocorticoid

2013
A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response.
    Pharmacological research, 2015, Volume: 99

    Topics: Administration, Inhalation; Animals; Asthma; Azabicyclo Compounds; B-Lymphocytes; Cell Degranulation; Cell Line; Disease Models, Animal; Humans; Indazoles; Intracellular Signaling Peptides and Proteins; Male; Mast Cells; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Inbred BN; Rats, Wistar; Syk Kinase

2015
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
    Journal of medicinal chemistry, 2015, Sep-24, Volume: 58, Issue:18

    Topics: Administration, Inhalation; Animals; Asthma; Female; Humans; Indazoles; Indoles; Isoenzymes; Male; Microsomes; Molecular Docking Simulation; Ovalbumin; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rabbits; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Th2 Cells

2015
Potent ameliorating effect of Hypoxia-inducible factor 1α (HIF-1α) antagonist YC-1 on combined allergic rhinitis and asthma syndrome (CARAS) in Rats.
    European journal of pharmacology, 2016, Oct-05, Volume: 788

    Topics: Animals; Anti-Allergic Agents; Asthma; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Lung; Male; Nasal Mucosa; Ovalbumin; PPAR alpha; Rats; Rats, Sprague-Dawley; Rhinitis, Allergic; RNA, Messenger; Transcription Factor RelA

2016
Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship.
    Bioorganic & medicinal chemistry, 2011, Feb-01, Volume: 19, Issue:3

    Topics: Administration, Inhalation; Aminopyridines; Asthma; Binding, Competitive; Drug Design; HEK293 Cells; Humans; I-kappa B Kinase; Indazoles; Isonicotinic Acids; Microsomes, Liver; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Niacinamide; Phenethylamines; Potassium Channel Blockers; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Structure-Activity Relationship; Sulfonamides

2011
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.
    Journal of molecular medicine (Berlin, Germany), 2013, Volume: 91, Issue:5

    Topics: Airway Resistance; Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemotaxis; Eosinophils; Female; Gene Expression Regulation; Goblet Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Interleukin-13; Interleukin-4; Interleukin-5; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovalbumin; Signal Transduction

2013
Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation.
    Cell biology and toxicology, 1996, Volume: 12, Issue:4-6

    Topics: Antigens; Asthma; Bronchi; Bronchodilator Agents; Cell Separation; Humans; Hydroxy Acids; Indazoles; Leukotriene D4; Muscle, Smooth; Norepinephrine; Propionates; Pulmonary Veins; Quinolines

1996
Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma.
    Biochemical pharmacology, 1992, Oct-06, Volume: 44, Issue:7

    Topics: Asthma; Binding Sites; Chromones; Dicarboxylic Acids; Humans; Indazoles; Kinetics; Lung; Receptors, Immunologic; Receptors, Leukotriene; Software; SRS-A; Thiazoles

1992
Further evidence that leukotrienes are the major mediators of allergic constriction in human bronchi.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: Allergens; Antibodies, Anti-Idiotypic; Asthma; Bronchi; Bronchoconstriction; Histamine Antagonists; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Indazoles; Indoles; Leukotriene Antagonists; Leukotrienes; Male; Middle Aged

1991
Effects of combined receptor antagonists of leukotriene D4 (LTD4) and platelet-activating factor (PAF) on rhesus airway responses to LTD4, PAF and antigen.
    International archives of allergy and applied immunology, 1989, Volume: 88, Issue:4

    Topics: Animals; Ascaris; Asthma; Drug Therapy, Combination; Female; Immunoglobulin E; Indazoles; Macaca mulatta; Male; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyrazoles; Quinolinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Leukotriene; SRS-A

1989