indapamide has been researched along with Muscle Contraction in 10 studies
Indapamide: A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
indapamide : A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, in the experimental groups dose-response curves to NE (10(-8) to 10(-4) M) and to KCI (20-120 mM) were shifted upward and to the left with respect to the control hypercholesterolemic group." | 1.29 | Effects of indapamide on vascular reactivity in hypercholesterolemic rabbits. ( Chulia, T; Del Rio, M; Tejerina, T, 1993) |
| "Indapamide was a far more potent inhibitor, a 10 microM concentration shifting the calcium dose-response curve 3 log units to the right and reducing maximal calcium contraction by 72% (P < ." | 1.29 | Ion channel involvement in the acute vascular effects of thiazide diuretics and related compounds. ( Calder, JA; Schachter, M; Sever, PS, 1993) |
| "5-OH-Indapamide is a principal metabolite of indapamide, and possesses similar antihypertensive and diuretic properties." | 1.29 | Vasorelaxant actions of 5-OH-indapamide, a major metabolite of indapamide: comparison with indapamide, hydrochlorothiazide and cicletanine. ( Calder, JA; Schachter, M; Sever, PS, 1994) |
| "Indapamide has a prolonged saluretic action which in combination with the direct vascular effects may well account for its antihypertensive activity." | 1.25 | Antihypertensive action of indapamide. Comparative studies in several experimental models. ( Kyncl, J; Oheim, K; Seki, T; Solles, A, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 7 (70.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mironneau, J | 2 |
| Savineau, JP | 1 |
| Mironneau, C | 1 |
| Contard, F | 1 |
| Glukhova, M | 1 |
| Sabri, A | 1 |
| Marotte, F | 1 |
| Sartore, S | 1 |
| Narcisse, G | 1 |
| Schatz, C | 1 |
| Guez, D | 1 |
| Rappaport, L | 1 |
| Samuel, JL | 1 |
| Del Rio, M | 2 |
| Chulia, T | 2 |
| Tejerina, T | 2 |
| Calder, JA | 2 |
| Schachter, M | 2 |
| Sever, PS | 2 |
| Gonzalez, P | 1 |
| Boulanger, CM | 1 |
| Mombouli, JV | 1 |
| Vanhoutte, PM | 1 |
| Rabkin, SW | 1 |
| Gargouil, YM | 1 |
| Kyncl, J | 1 |
| Oheim, K | 1 |
| Seki, T | 1 |
| Solles, A | 1 |
10 other studies available for indapamide and Muscle Contraction
| Article | Year |
|---|---|
Compared effects of indapamide, hydrochlorothiazide and chlorthalidone on electrical and mechanical activities in vascular smooth muscle.
Topics: Animals; Calcium; Chlorthalidone; Diuretics; Hydrochlorothiazide; In Vitro Techniques; Indapamide; M | 1981 |
Comparative effects of indapamide and hydrochlorothiazide on cardiac hypertrophy and vascular smooth-muscle phenotype in the stroke-prone, spontaneously hypertensive rat.
Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Vessels; Hydrochlorothiazide; Hypertension; Indapami | 1993 |
Effects of indapamide on vascular reactivity in hypercholesterolemic rabbits.
Topics: Animals; Cholesterol, Dietary; Dose-Response Relationship, Drug; Femoral Artery; Hypercholesterolemi | 1993 |
Ion channel involvement in the acute vascular effects of thiazide diuretics and related compounds.
Topics: Animals; Calcium Channels; Charybdotoxin; Diuretics; Drug Interactions; Glyburide; Guinea Pigs; Hydr | 1993 |
Vasorelaxant actions of 5-OH-indapamide, a major metabolite of indapamide: comparison with indapamide, hydrochlorothiazide and cicletanine.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Calcium Channels; Electromyography; Endothelium, Vasc | 1994 |
Effects of indapamide on contractile responses and 45Ca2+ movements in various isolated blood vessels.
Topics: Animals; Aorta; Basilar Artery; Blood Vessels; Calcium; Electrophysiology; Female; Femoral Artery; I | 1993 |
Indapamide inhibits endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosp | 1993 |
Indapamide accentuates cardiac chronotropic responses to epidermal growth factor in chick cardiomyocytes.
Topics: Animals; Antihypertensive Agents; Cells, Cultured; Chick Embryo; Epidermal Growth Factor; Heart Rate | 1996 |
Action of indapamide on excitation-contraction coupling in vascular smooth muscle.
Topics: Action Potentials; Animals; Calcium; Diuretics; In Vitro Techniques; Indapamide; Manganese; Muscle C | 1979 |
Antihypertensive action of indapamide. Comparative studies in several experimental models.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Chlorthalidone; Diuretics; Dogs; | 1975 |