indapamide has been researched along with Hypokalemia in 41 studies
Indapamide: A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
indapamide : A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The fixed low-dose combination of the ACE inhibitor perindopril and the non-thiazide diuretic indapamide has been evaluated in the management of patients with mild to moderate hypertension." | 8.81 | Perindopril/indapamide 2/0.625 mg/day: a review of its place in the management of hypertension. ( Cheer, SM; Goa, KL; Matheson, AJ, 2001) |
| "The aim of this study is to evaluate patients' demographics, patterns of presentation and outcomes of admissions with severe hyponatremia and other electrolyte disturbances that are related to indapamide." | 7.77 | Severe hyponatremia and other electrolyte disturbances associated with indapamide. ( Huang, JE; Lau, SY; Li, JY; Yong, TY, 2011) |
| " We detailed a case in which concomitant-acquired LQTS and Brugada syndrome were associated with severe hypokalemia and hyponatremia following indapamide use for treatment of hypertension and highlighted the potential role of hyponatremia in the pathogenesis of the acquired form of Brugada syndrome." | 7.74 | Concomitant-acquired Long QT and Brugada syndromes associated with indapamide-induced hypokalemia and hyponatremia. ( Mok, NS; Tong, CK; Yuen, HC, 2008) |
| "To describe 2 patients with severe indapamide-induced hyponatremia and hypokalemia and to discuss the incidence and mechanisms of diuretic-induced hyponatremia and hypokalemia." | 7.69 | Indapamide-induced severe hyponatremia and hypokalemia. ( Chan, TY, 1995) |
| "We report on two patients, treated with indapamide for mild hypertension, who developed life-threatening ventricular arrhythmias." | 7.68 | [Severe ventricular arrhythmia secondary to indapamide-induced hypopotassemia]. ( Baroffio, R; Coppetti, D; Gasparini, P; Guzzini, F, 1990) |
| "Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage." | 6.65 | Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983) |
| "Indapamide was immediately stopped, but the QT remained prolonged 2 days later, although the potassium level was normalized." | 5.31 | Indapamide induced syncope in a patient with long QT syndrome. ( Guo, GB; Wang, CP, 2002) |
| "Indapamide was given in doses of 2." | 5.27 | Clinical efficacy and safety of indapamide in the treatment of edema. ( Slotkoff, L, 1983) |
| "Indapamide is a diuretic prescribed in the treatment of hypertension at the dosage of 2." | 5.08 | [Therapeutic benefit of a low dose of indapamide: results of a double-blind against placebo European controlled study]. ( Asmar, R; Barrandon, S; Brault, Y; Bruxelles, MC; Chastang, C; de Cordoue, A; Guez, D; Malbezin, M, 1995) |
| "The fixed low-dose combination of the ACE inhibitor perindopril and the non-thiazide diuretic indapamide has been evaluated in the management of patients with mild to moderate hypertension." | 4.81 | Perindopril/indapamide 2/0.625 mg/day: a review of its place in the management of hypertension. ( Cheer, SM; Goa, KL; Matheson, AJ, 2001) |
| "The aim of this study is to evaluate patients' demographics, patterns of presentation and outcomes of admissions with severe hyponatremia and other electrolyte disturbances that are related to indapamide." | 3.77 | Severe hyponatremia and other electrolyte disturbances associated with indapamide. ( Huang, JE; Lau, SY; Li, JY; Yong, TY, 2011) |
| " We detailed a case in which concomitant-acquired LQTS and Brugada syndrome were associated with severe hypokalemia and hyponatremia following indapamide use for treatment of hypertension and highlighted the potential role of hyponatremia in the pathogenesis of the acquired form of Brugada syndrome." | 3.74 | Concomitant-acquired Long QT and Brugada syndromes associated with indapamide-induced hypokalemia and hyponatremia. ( Mok, NS; Tong, CK; Yuen, HC, 2008) |
| "To describe 2 patients with severe indapamide-induced hyponatremia and hypokalemia and to discuss the incidence and mechanisms of diuretic-induced hyponatremia and hypokalemia." | 3.69 | Indapamide-induced severe hyponatremia and hypokalemia. ( Chan, TY, 1995) |
| "We report on two patients, treated with indapamide for mild hypertension, who developed life-threatening ventricular arrhythmias." | 3.68 | [Severe ventricular arrhythmia secondary to indapamide-induced hypopotassemia]. ( Baroffio, R; Coppetti, D; Gasparini, P; Guzzini, F, 1990) |
| "Indapamide is a useful antihypertensive agent with good patient tolerance in mild or moderate hypertension and may offer advantages over traditional diuretics in view of its possible vasodilator and calcium-antagonist properties, once-a-day dosage, and good therapeutic effect with prolonged usage." | 2.65 | Clinical efficacy and safety of indapamide in essential hypertension. ( Morledge, JH, 1983) |
| "Hydrochlorothiazide (HCTZ) has often been contrasted with chlorthalidone, but relatively little is known about HCTZ versus indapamide (INDAP)." | 2.52 | Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects. ( Ernst, ME; Kostis, JB; Roush, GC; Sica, DA; Tandon, S, 2015) |
| "Diuretics are commonly used for the treatment of hypertension." | 1.91 | Incidence of severe hypokalaemia in patients taking indapamide. ( Cheung, BMY; Lin, Z; Tang, V; Tsoi, MF, 2023) |
| "Indapamide is a sulfonamide diuretic with vasodilative and calcium antagonistic effects, which enhances sodium delivery to the renal distal tubules resulting in a dose-related increase in urinary potassium excretion and decreases serum potassium concentrations." | 1.91 | [Intraoperative management of potentially fatal arrhythmias after anesthesia induced by severe hypokalemia: A case report]. ( Guo, XY; Wang, JC; Yao, YX, 2023) |
| "Indapamide was immediately stopped, but the QT remained prolonged 2 days later, although the potassium level was normalized." | 1.31 | Indapamide induced syncope in a patient with long QT syndrome. ( Guo, GB; Wang, CP, 2002) |
| "Indapamide was five times more frequently prescribed in GOPC than SC (84." | 1.30 | Use of indapamide in hospital and community clinics and its effect on plasma potassium in Chinese patients. ( Chan, GM; Chan, JC; Chan, WH; Chang, S; Critchley, JA; Kong, Y; Lee, A; Lee, SC; Raymond, K, 1998) |
| "Indapamide was given in doses of 2." | 1.27 | Clinical efficacy and safety of indapamide in the treatment of edema. ( Slotkoff, L, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (43.90) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 8 (19.51) | 29.6817 |
| 2010's | 5 (12.20) | 24.3611 |
| 2020's | 2 (4.88) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, Z | 1 |
| Cheung, BMY | 1 |
| Tang, V | 1 |
| Tsoi, MF | 1 |
| Wang, JC | 1 |
| Yao, YX | 1 |
| Guo, XY | 1 |
| Liang, W | 1 |
| Ma, H | 1 |
| Cao, L | 1 |
| Yan, W | 1 |
| Yang, J | 1 |
| Roush, GC | 1 |
| Ernst, ME | 1 |
| Kostis, JB | 1 |
| Tandon, S | 1 |
| Sica, DA | 1 |
| Mok, NS | 1 |
| Tong, CK | 1 |
| Yuen, HC | 1 |
| Chan, TY | 2 |
| Gomersall, CD | 1 |
| Cheng, CA | 1 |
| Woo, J | 1 |
| Nedogoda, SV | 1 |
| Ohashi, N | 1 |
| Minemura, S | 1 |
| Togawa, A | 1 |
| Ohyama, K | 1 |
| Yong, TY | 1 |
| Huang, JE | 1 |
| Lau, SY | 1 |
| Li, JY | 1 |
| Wang, CP | 1 |
| Guo, GB | 1 |
| Hamano, T | 1 |
| Yamamoto, T | 1 |
| Miyamori, I | 1 |
| Kuriyama, M | 1 |
| Nardoni, A | 1 |
| Marchetti, E | 1 |
| Di Piazza, V | 1 |
| Rossi, G | 1 |
| Cella, R | 1 |
| Morledge, JH | 1 |
| Beling, S | 1 |
| Vukovich, RA | 1 |
| Neiss, ES | 1 |
| Zisblatt, M | 1 |
| Webb, E | 1 |
| Losi, M | 1 |
| de Ortiz, H | 1 |
| DeQuattro, E | 1 |
| Stephanian, E | 1 |
| DeQuattro, V | 1 |
| Slotkoff, L | 1 |
| Perry, HM | 1 |
| Boulton, AJ | 1 |
| Hardisty, CA | 1 |
| Asmar, R | 1 |
| Guez, D | 2 |
| Malbezin, M | 1 |
| Brault, Y | 1 |
| de Cordoue, A | 2 |
| Barrandon, S | 2 |
| Bruxelles, MC | 1 |
| Chastang, C | 2 |
| Mallion, JM | 1 |
| Degaute, JP | 1 |
| Malini, PL | 1 |
| Baldwin, R | 1 |
| Rodriguez-Pujol, D | 1 |
| Safar, M | 1 |
| Chang, S | 1 |
| Chan, WH | 1 |
| Kong, Y | 1 |
| Chan, GM | 1 |
| Raymond, K | 1 |
| Lee, A | 1 |
| Lee, SC | 1 |
| Critchley, JA | 1 |
| Chan, JC | 1 |
| Matheson, AJ | 1 |
| Cheer, SM | 1 |
| Goa, KL | 1 |
| Chapman, MD | 1 |
| Hanrahan, R | 1 |
| McEwen, J | 1 |
| Marley, JE | 1 |
| Howes, LG | 1 |
| Schultz, EL | 1 |
| Seftel, HC | 1 |
| Richard, A | 1 |
| Haroche, G | 1 |
| Lang, T | 1 |
| Lafaix, C | 1 |
| Rodat, O | 1 |
| Hamelin, JP | 1 |
| Thill, R | 1 |
| Hatt, PY | 1 |
| Leblond, JB | 1 |
| Guzzini, F | 1 |
| Baroffio, R | 1 |
| Coppetti, D | 1 |
| Gasparini, P | 1 |
| Clarke, RJ | 1 |
| Thomsen, JF | 1 |
| Feldt-Rasmussen, BF | 1 |
| Wanamaker, HH | 1 |
| Flanzer, JM | 1 |
| Silverstein, H | 1 |
| Meregalli, M | 1 |
| Bertola, G | 1 |
| Torchio, G | 1 |
| Bocchia, M | 1 |
| Greenberg, A | 1 |
| Di Giacomo, V | 1 |
| Tedeschi, A | 1 |
| Rizzi, R | 1 |
| Micoli, A | 1 |
| Giaculli, G | 1 |
| Lella, A | 1 |
| Mariella, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fixed-Dose Combination of Perindopril/Amlodipine (Amlessa®) and Fixed-Dose Combination of Perindopril/Indapamide /Amlodipine (Co-Amlessa®) - Contribution to Management in Newly Diagnosed and Uncontrolled Hypertensive Patients[NCT03738761] | Phase 4 | 471 participants (Actual) | Interventional | 2018-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for indapamide and Hypokalemia
| Article | Year |
|---|---|
Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis.
Topics: Antihypertensive Agents; Blood Glucose; Blood Pressure; Chlorthalidone; Cholesterol; Diuretics; Huma | 2017 |
Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects.
Topics: Blood Pressure; Chlorthalidone; Diuretics; Humans; Hydrochlorothiazide; Hypertension; Hypokalemia; I | 2015 |
[Hyponatremia with somnolence due to indapamide].
Topics: Aged, 80 and over; Antihypertensive Agents; Disorders of Excessive Somnolence; Diuretics; Female; Hu | 2008 |
Perindopril/indapamide 2/0.625 mg/day: a review of its place in the management of hypertension.
Topics: Adult; Age Factors; Aged; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; | 2001 |
Indapamide: a diuretic of choice for the treatment of hypertension?
Topics: Blood Glucose; Humans; Hyperlipidemias; Hypertension; Hypokalemia; Indapamide; Meta-Analysis as Topi | 1991 |
6 trials available for indapamide and Hypokalemia
| Article | Year |
|---|---|
Clinical efficacy and safety of indapamide in essential hypertension.
Topics: Adult; Aged; Animals; Clinical Trials as Topic; Diuretics; Double-Blind Method; Electrolytes; Humans | 1983 |
Long-term experience with indapamide.
Topics: Adult; Aged; Clinical Trials as Topic; Diuretics; Double-Blind Method; Female; Humans; Hydrochloroth | 1983 |
[Therapeutic benefit of a low dose of indapamide: results of a double-blind against placebo European controlled study].
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; Human | 1995 |
[Treatment of hypertension with indapamide 1.5 mg sustained-release form: synthesis of results].
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Doubl | 1996 |
Hypokalaemia in hypertensive Blacks treated with diuretics.
Topics: Black or African American; Black People; Diuretics; Female; Humans; Hydrochlorothiazide; Hypokalemia | 1978 |
A comparative study of the activity of a new agent, indapamide, in essential arterial hypertension.
Topics: Aged; Chlorthalidone; Clinical Trials as Topic; Diuretics; Drug Evaluation; Drug Tolerance; Female; | 1975 |
30 other studies available for indapamide and Hypokalemia
| Article | Year |
|---|---|
Incidence of severe hypokalaemia in patients taking indapamide.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Diuretics; Female; Human | 2023 |
[Intraoperative management of potentially fatal arrhythmias after anesthesia induced by severe hypokalemia: A case report].
Topics: Aged; Anesthesia, General; Arrhythmias, Cardiac; Diuretics; Electrolytes; Humans; Hypokalemia; Indap | 2023 |
Concomitant-acquired Long QT and Brugada syndromes associated with indapamide-induced hypokalemia and hyponatremia.
Topics: Antihypertensive Agents; Brugada Syndrome; Humans; Hypokalemia; Hyponatremia; Indapamide; Long QT Sy | 2008 |
Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patient.
Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Antihypertensive Agents; Combined Modali | 2009 |
[Diuretics in arterial hypertension: what is the basis of modern therapy].
Topics: Antihypertensive Agents; Carbohydrate Metabolism; Clinical Trials as Topic; Diuretics; Drug Therapy, | 2010 |
A case of hypokalemia-induced fatal arrhythmia caused by indapamide in an anorexic elderly patient.
Topics: Aged, 80 and over; Anorexia; Arrhythmias, Cardiac; Diuretics; Heart Arrest; Humans; Hypokalemia; Ind | 2011 |
Severe hyponatremia and other electrolyte disturbances associated with indapamide.
Topics: Aged; Aged, 80 and over; Diuretics; Electrocardiography; Electrolytes; Female; Hospitals, Teaching; | 2011 |
Indapamide induced syncope in a patient with long QT syndrome.
Topics: Antihypertensive Agents; Electrocardiography; Female; Humans; Hypertension; Hypokalemia; Indapamide; | 2002 |
Hypokalaemia and hyponatraemia due to indapamide.
Topics: Amiloride; Australia; France; Humans; Hydrochlorothiazide; Hypokalemia; Hyponatremia; Indapamide; Ph | 2002 |
[Normokaliuretic hypokalemia during inadapamide treatment of hypertension].
Topics: Adult; Aged; Diuretics; Female; Humans; Hypertension; Hypokalemia; Indapamide; Male; Middle Aged; Po | 1984 |
Long-term effectiveness of indapamide in hypertension: neural, renin and metabolic responses.
Topics: Adult; Aged; Blood Pressure; Diuretics; Female; Follow-Up Studies; Heart Rate; Humans; Hyperglycemia | 1983 |
Hypokalaemia and xipamide.
Topics: Aged; Diuretics; Female; Humans; Hypokalemia; Indapamide; Male; Xipamide | 1982 |
Clinical efficacy and safety of indapamide in the treatment of edema.
Topics: Body Weight; Diuretics; Double-Blind Method; Edema; Electrolytes; Female; Humans; Hydrochlorothiazid | 1983 |
Some wrong-way chemical changes during antihypertensive treatment: comparison of indapamide and related agents.
Topics: Adult; Antihypertensive Agents; Chemical Phenomena; Chemistry; Chlorthalidone; Diuretics; Humans; Hy | 1983 |
Ventricular arrhythmias precipitated by treatment with non-thiazide diuretics.
Topics: Aged; Arrhythmias, Cardiac; Diuretics; Drug Therapy, Combination; Female; Heart Ventricles; Humans; | 1982 |
[Diabetes mellitus and hypokalemia during indapamide and furosemide therapy].
Topics: Diabetes Mellitus; Diuretics; Furosemide; Humans; Hypokalemia; Indapamide; Male; Middle Aged | 1982 |
Indapamide-induced severe hyponatremia and hypokalemia.
Topics: Diabetes Mellitus, Type 2; Diagnosis, Differential; Diuretics; Female; Humans; Hypokalemia; Hyponatr | 1995 |
Use of indapamide in hospital and community clinics and its effect on plasma potassium in Chinese patients.
Topics: Aged; Antihypertensive Agents; Asian People; Data Interpretation, Statistical; Diuretics; Drug Presc | 1998 |
Hyponatraemia and hypokalaemia due to indapamide.
Topics: Amiloride; Australia; Chlorothiazide; Diuretics; Drug Combinations; Drug Utilization; Humans; Hydroc | 2002 |
Hyponatraemia and hypokalaemia caused by indapamide.
Topics: Diuretics; Humans; Hypokalemia; Hyponatremia; Indapamide | 2002 |
[Hypokalemia during treatment with indapamide. 3 cases].
Topics: Aged; Diuretics; Female; Humans; Hypertension; Hypokalemia; Indapamide | 1978 |
[Hypokalemia of 0 9 mEq during treatment with indapamide].
Topics: Aged; Diuretics; Humans; Hypokalemia; Indapamide; Male | 1978 |
[Indapamide].
Topics: Aged; Diuretics; Humans; Hypertension; Hypokalemia; Indapamide | 1978 |
[Severe ventricular arrhythmia secondary to indapamide-induced hypopotassemia].
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electrocardiography; Fe | 1990 |
[Severe hypokalemia and hyperglycemia developed during indapamide therapy].
Topics: Humans; Hypoglycemia; Hypokalemia; Indapamide; Male; Middle Aged | 1991 |
Indapamide to treat Menière's disease.
Topics: Humans; Hypokalemia; Indapamide; Meniere Disease | 1991 |
[2 clinical cases of hypopotassemia during treatment with indapamide].
Topics: Aged; Aged, 80 and over; Diuretics; Female; Humans; Hypokalemia; Indapamide; Male; Middle Aged | 1989 |
What's new in diuretic therapy.
Topics: Acetazolamide; Acid-Base Imbalance; Biological Transport; Diuretics; Drug Resistance; Ethacrynic Aci | 1986 |
[Severe hypokalemic episode induced by abuse of fluoro-prednisolone acetate administered nasally and the simultaneous oral consumption of indapamide].
Topics: Administration, Oral; Adult; Diuretics; Fluprednisolone; Humans; Hypokalemia; Indapamide; Male; Nose | 1985 |
[Hypokalemic myopathy during prolonged anti-hypertensive therapy with indapamide].
Topics: Aged; Diuretics; Female; Heart Diseases; Humans; Hypokalemia; Indapamide; Kidney Diseases; Muscle Hy | 1985 |