indapamide has been researched along with Albuminuria in 24 studies
Indapamide: A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
indapamide : A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.
Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the antihypertensive efficacy and safety of indapamide sustained-release (SR)/amlodipine compared with enalapril/amlodipine in patients 65 years and older with uncontrolled blood pressure (BP) on monotherapy, a post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria) was conducted." | 9.24 | Blood pressure-lowering efficacy of indapamide SR/amlodipine combination in older patients with hypertension: A post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria). ( Boully, C; Caillard, L; Chaussade, E; Hanon, O; Hernandorena, I, 2017) |
| "Hypertensive diabetic patients with microalbuminuria were included in this retrospective, post-hoc analysis of the Natrilix SR Versus Enalapril Study in Hypertensive Type 2 Diabetics With MicrOalbuminuRia (NESTOR) trial if they were uncontrolled on monotherapy (indapamide slow release (SR) 1." | 9.20 | Treatment of Hypertensive Patients With Diabetes and Microalbuminuria With Combination Indapamide SR/Amlodipine: Retrospective Analysis of NESTOR. ( Boully, C; Caillard, L; Chaussade, E; Cochiello, S; Hanon, O; Labourée, F, 2015) |
| "To test whether microalbuminuria in patients with type 2 diabetes and hypertension is primarily dependent on the severity of hypertension, and to compare the effectiveness of two antihypertensive drugs with opposite effects on the renin-angiotensin system [the diuretic, indapamide sustained release (SR), and an angiotensin-converting enzyme inhibitor, enalapril] in reducing microalbuminuria." | 9.11 | Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study. ( Amouyel, P; Asmar, R; Fernandez, M; Finizola, B; Gallois, Y; Halabe, A; Hermansen, K; Ionescu-Tirgoviste, C; Jermendy, G; Kokot, F; Marre, M; Mion Júnior, D; Moyseev, V; Ollivier, JP; Opie, L; Puig, JG; Ruiz, M; Saldanha, MH; Scheen, A; Tuomilehto, J; Williams, B, 2004) |
| "To examine the factors that determine the blood pressure response to enalapril and nifedipine monotherapy in the treatment of hypertension associated with non-insulin-dependent diabetes mellitus (NIDDM)." | 9.08 | Factors determining the blood pressure response to enalapril and nifedipine in hypertension associated with NIDDM. ( Chan, JC; Cheung, CK; Cockram, CS; Law, LK; Nicholls, MG; Swaminathan, R, 1995) |
| " In this study, 21 patients with noninsulin-dependent diabetes and hypertension (11 with normoalbuminuria and 10 with microalbuminuria), who were comparable for age, duration of diabetes and hypertension, were treated with indapamide, 2." | 7.68 | Efficacy of antihypertensive treatment with indapamide in patients with noninsulin-dependent diabetes and persistent microalbuminuria. ( Frontoni, S; Gambardella, S; Gargiulo, P; Grazia Felici, M; Menzinger, G; Morano, S; Spallone, V, 1990) |
| "The effects of indapamide on diabetic patients with micro-albuminuria were evaluated in a multicentre study to assess the advantages of this compound in long-term renal protection." | 7.67 | Hypertension and micro-albuminuria in diabetic patients taking indapamide. ( Blümner, E; Janka, HU; Mehnert, H; van Michel, A; Weitz, T, 1989) |
| " Perindopril/indapamide dosage could be increased, from 5/1." | 6.79 | Efficacy of single-pill perindopril/indapamide in patients with hypertension and type 2 diabetes. ( Gorbat, TV; Netchessova, TA; Shepelkevich, AP, 2014) |
| "Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (-3." | 6.71 | Effect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER. ( De Leeuw, PW; Erdogan, G; Halimi, S; Hamani, A; Hess, B; Jermendy, G; Luger, A; Mechmeche, R; Mogensen, CE; Nolan, J; Ribeiro, A; Ritz, E; Ruilope, L; Rull, J; Sanchez, R; Sareli, P; Scheen, A; Sirotiakova, J; Taton, J; Thomas, SM; Viberti, G; Widimsky, J, 2003) |
| "To examine the antihypertensive efficacy and safety of indapamide sustained-release (SR)/amlodipine compared with enalapril/amlodipine in patients 65 years and older with uncontrolled blood pressure (BP) on monotherapy, a post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria) was conducted." | 5.24 | Blood pressure-lowering efficacy of indapamide SR/amlodipine combination in older patients with hypertension: A post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria). ( Boully, C; Caillard, L; Chaussade, E; Hanon, O; Hernandorena, I, 2017) |
| "Hypertensive diabetic patients with microalbuminuria were included in this retrospective, post-hoc analysis of the Natrilix SR Versus Enalapril Study in Hypertensive Type 2 Diabetics With MicrOalbuminuRia (NESTOR) trial if they were uncontrolled on monotherapy (indapamide slow release (SR) 1." | 5.20 | Treatment of Hypertensive Patients With Diabetes and Microalbuminuria With Combination Indapamide SR/Amlodipine: Retrospective Analysis of NESTOR. ( Boully, C; Caillard, L; Chaussade, E; Cochiello, S; Hanon, O; Labourée, F, 2015) |
| "Indapamide SR is not less effective than enalapril in reducing microalbuminuria and blood pressure in patients aged >65 years of age with type 2 diabetes and hypertension." | 5.12 | Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes. ( Amouyel, P; Asmar, R; Fernandez, M; Finizola, B; Gallois, Y; Halabe, A; Hermansen, K; Ionescu-Tirgoviste, C; Jermendy, G; Kokot, F; Marre, M; Mion, D; Moyseev, V; Ollivier, JP; Opie, L; Puig, JG; Ruiz, M; Saldanha, MH; Scheen, A; Tuomilehto, J; Williams, B, 2007) |
| "To test whether microalbuminuria in patients with type 2 diabetes and hypertension is primarily dependent on the severity of hypertension, and to compare the effectiveness of two antihypertensive drugs with opposite effects on the renin-angiotensin system [the diuretic, indapamide sustained release (SR), and an angiotensin-converting enzyme inhibitor, enalapril] in reducing microalbuminuria." | 5.11 | Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study. ( Amouyel, P; Asmar, R; Fernandez, M; Finizola, B; Gallois, Y; Halabe, A; Hermansen, K; Ionescu-Tirgoviste, C; Jermendy, G; Kokot, F; Marre, M; Mion Júnior, D; Moyseev, V; Ollivier, JP; Opie, L; Puig, JG; Ruiz, M; Saldanha, MH; Scheen, A; Tuomilehto, J; Williams, B, 2004) |
| "The first fundamental study devoted to the reduction of microalbuminuria with a antihypertensive diuretic (indapamide SR) in type 2 diabetes with hypertension, the Marre study (NESTOR) was designed to demonstrate that this antihypertension agent could be an interesting therapeutic alternative by comparing its efficacy on microalbuminuria with that of enalapril 10 mg during a treatment period of 52 weeks." | 5.10 | [Treatment of hypertensive type 2 diabetes patients with microalbuminuria]. ( Marre, M, 2002) |
| "To examine the factors that determine the blood pressure response to enalapril and nifedipine monotherapy in the treatment of hypertension associated with non-insulin-dependent diabetes mellitus (NIDDM)." | 5.08 | Factors determining the blood pressure response to enalapril and nifedipine in hypertension associated with NIDDM. ( Chan, JC; Cheung, CK; Cockram, CS; Law, LK; Nicholls, MG; Swaminathan, R, 1995) |
| " In this study, 21 patients with noninsulin-dependent diabetes and hypertension (11 with normoalbuminuria and 10 with microalbuminuria), who were comparable for age, duration of diabetes and hypertension, were treated with indapamide, 2." | 3.68 | Efficacy of antihypertensive treatment with indapamide in patients with noninsulin-dependent diabetes and persistent microalbuminuria. ( Frontoni, S; Gambardella, S; Gargiulo, P; Grazia Felici, M; Menzinger, G; Morano, S; Spallone, V, 1990) |
| "The effects of indapamide on diabetic patients with micro-albuminuria were evaluated in a multicentre study to assess the advantages of this compound in long-term renal protection." | 3.67 | Hypertension and micro-albuminuria in diabetic patients taking indapamide. ( Blümner, E; Janka, HU; Mehnert, H; van Michel, A; Weitz, T, 1989) |
| " Perindopril/indapamide dosage could be increased, from 5/1." | 2.79 | Efficacy of single-pill perindopril/indapamide in patients with hypertension and type 2 diabetes. ( Gorbat, TV; Netchessova, TA; Shepelkevich, AP, 2014) |
| "Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (-3." | 2.71 | Effect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER. ( De Leeuw, PW; Erdogan, G; Halimi, S; Hamani, A; Hess, B; Jermendy, G; Luger, A; Mechmeche, R; Mogensen, CE; Nolan, J; Ribeiro, A; Ritz, E; Ruilope, L; Rull, J; Sanchez, R; Sareli, P; Scheen, A; Sirotiakova, J; Taton, J; Thomas, SM; Viberti, G; Widimsky, J, 2003) |
| "Indapamide has a dual mechanism of action: diuretic effect at the level of the distal tubule in the kidney and a direct vascular effect, both of which contribute to the antihypertensive efficacy of the drug." | 2.43 | An overview of the pharmacology and clinical efficacy of indapamide sustained release. ( Bataillard, A; McIntyre, H; Sassard, J, 2005) |
| "The treatment with indapamide SR resulted in a better or equivalent control of SBP than treatment with a standard dose of a true thiazide diuretic (hydrochlorothiazide), a calcium channel blocker (amlodipine), and an angiotensin-converting enzyme inhibitor (enalapril)." | 2.42 | Efficacy of indapamide 1.5 mg, sustained release, in the lowering of systolic blood pressure. ( London, GM, 2004) |
| "Factors that must be considered for the treatment of hypertension in patients, particularly with type 2 diabetes." | 1.31 | [Reflexion of French experts on the key points of the symposium]. ( Dubourg, O; Forette, F; Hanon, O; Mallion, JM; Marre, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 13 (54.17) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hanon, O | 3 |
| Caillard, L | 2 |
| Chaussade, E | 2 |
| Hernandorena, I | 1 |
| Boully, C | 2 |
| Mohammedi, K | 1 |
| Chalmers, J | 3 |
| Herrington, W | 1 |
| Li, Q | 1 |
| Mancia, G | 3 |
| Marre, M | 8 |
| Poulter, N | 3 |
| Rodgers, A | 1 |
| Williams, B | 5 |
| Perkovic, V | 3 |
| Coresh, J | 1 |
| Woodward, M | 3 |
| Netchessova, TA | 1 |
| Shepelkevich, AP | 1 |
| Gorbat, TV | 1 |
| Labourée, F | 1 |
| Cochiello, S | 1 |
| de Galan, BE | 2 |
| Ninomiya, T | 2 |
| Pillai, A | 2 |
| Patel, A | 2 |
| Cass, A | 2 |
| Neal, B | 2 |
| Harrap, S | 2 |
| Mogensen, CE | 3 |
| Cooper, M | 1 |
| Hamet, P | 2 |
| Glasziou, P | 2 |
| Grobbee, DE | 1 |
| MacMahon, S | 2 |
| Zoungas, S | 1 |
| Grobbee, D | 1 |
| Heller, S | 1 |
| Lisheng, L | 1 |
| Travert, F | 1 |
| Kaplan, NM | 1 |
| Mallion, JM | 1 |
| Forette, F | 1 |
| Dubourg, O | 1 |
| Viberti, G | 1 |
| Halimi, S | 1 |
| Ritz, E | 1 |
| Ruilope, L | 1 |
| Jermendy, G | 4 |
| Widimsky, J | 1 |
| Sareli, P | 1 |
| Taton, J | 1 |
| Rull, J | 1 |
| Erdogan, G | 1 |
| De Leeuw, PW | 1 |
| Ribeiro, A | 1 |
| Sanchez, R | 1 |
| Mechmeche, R | 1 |
| Nolan, J | 1 |
| Sirotiakova, J | 1 |
| Hamani, A | 1 |
| Scheen, A | 4 |
| Hess, B | 1 |
| Luger, A | 1 |
| Thomas, SM | 1 |
| Garcia Puig, J | 1 |
| Kokot, F | 3 |
| Fernandez, M | 3 |
| Opie, L | 3 |
| Moyseev, V | 3 |
| Ionescu-Tirgoviste, C | 3 |
| Saldanha, MH | 3 |
| Halabe, A | 3 |
| Mion, D | 2 |
| Ruiz, M | 3 |
| Hermansen, K | 3 |
| Tuomilehto, J | 3 |
| Finizola, B | 3 |
| Pozza, G | 1 |
| Chastang, C | 1 |
| Ollivier, JP | 3 |
| Amouyel, P | 3 |
| Asmar, R | 3 |
| Puig, JG | 2 |
| Mion Júnior, D | 1 |
| Gallois, Y | 2 |
| London, GM | 1 |
| Sassard, J | 1 |
| Bataillard, A | 1 |
| McIntyre, H | 1 |
| Ruilope, LM | 1 |
| Segura, J | 1 |
| Flack, JR | 1 |
| Molyneaux, L | 1 |
| Willey, K | 1 |
| Yue, DK | 3 |
| Chan, JC | 1 |
| Nicholls, MG | 1 |
| Cheung, CK | 1 |
| Law, LK | 1 |
| Swaminathan, R | 1 |
| Cockram, CS | 1 |
| Donnelly, R | 1 |
| Molyneaux, LM | 2 |
| Willey, KA | 2 |
| Gambardella, S | 2 |
| Frontoni, S | 2 |
| Lala, A | 1 |
| Felici, MG | 1 |
| Spallone, V | 2 |
| Scoppola, A | 1 |
| Jacoangeli, F | 1 |
| Menzinger, G | 2 |
| Grazia Felici, M | 1 |
| Gargiulo, P | 1 |
| Morano, S | 1 |
| Janka, HU | 1 |
| Weitz, T | 1 |
| Blümner, E | 1 |
| van Michel, A | 1 |
| Mehnert, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ADVANCE - Action in Diabetes and Vascular Disease: Preterax and Diamicron - MR Controlled Evaluation[NCT00145925] | Phase 3 | 11,140 participants (Actual) | Interventional | 2001-06-30 | Completed | ||
| Fixed-Dose Combination of Perindopril/Amlodipine (Amlessa®) and Fixed-Dose Combination of Perindopril/Indapamide /Amlodipine (Co-Amlessa®) - Contribution to Management in Newly Diagnosed and Uncontrolled Hypertensive Patients[NCT03738761] | Phase 4 | 471 participants (Actual) | Interventional | 2018-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for indapamide and Albuminuria
| Article | Year |
|---|---|
Efficacy of indapamide 1.5 mg, sustained release, in the lowering of systolic blood pressure.
Topics: Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Delayed-Action Preparations; Diabetes Me | 2004 |
An overview of the pharmacology and clinical efficacy of indapamide sustained release.
Topics: Albuminuria; Antihypertensive Agents; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Eviden | 2005 |
Renal protection in diabetic patients: benefits of a first-line combination of perindopril-indapamide (Preterax).
Topics: Albuminuria; Antihypertensive Agents; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic | 2006 |
Comparative effects of indapamide and captopril on blood pressure and albumin excretion rate in diabetic microalbuminuria.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calc | 1996 |
15 trials available for indapamide and Albuminuria
| Article | Year |
|---|---|
Blood pressure-lowering efficacy of indapamide SR/amlodipine combination in older patients with hypertension: A post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria).
Topics: Aged; Aged, 80 and over; Albuminuria; Amlodipine; Antihypertensive Agents; Blood Pressure; Diabetes | 2017 |
Associations between body mass index and the risk of renal events in patients with type 2 diabetes.
Topics: Aged; Albuminuria; Blood Glucose; Body Mass Index; Creatinine; Diabetes Mellitus, Type 2; Drug Combi | 2018 |
Efficacy of single-pill perindopril/indapamide in patients with hypertension and type 2 diabetes.
Topics: Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Comorbidity; Diabetes Mellitus, Type 2; | 2014 |
Treatment of Hypertensive Patients With Diabetes and Microalbuminuria With Combination Indapamide SR/Amlodipine: Retrospective Analysis of NESTOR.
Topics: Aged; Albuminuria; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Ca | 2015 |
Lowering blood pressure reduces renal events in type 2 diabetes.
Topics: Age of Onset; Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2009 |
Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial.
Topics: Aged; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; | 2009 |
[Treatment of hypertensive type 2 diabetes patients with microalbuminuria].
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Creatinine; Data Int | 2002 |
Effect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER.
Topics: Adult; Aged; Albuminuria; Antihypertensive Agents; Blood Pressure; Cough; Diabetes Mellitus, Type 2; | 2003 |
Effect of indapamide SR on microalbuminuria--the NESTOR study (Natrilix SR versus Enalapril Study in Type 2 diabetic hypertensives with micrOalbuminuRia)--rationale and protocol for the main trial.
Topics: Adult; Aged; Albuminuria; Clinical Protocols; Creatine; Delayed-Action Preparations; Diabetes Mellit | 2003 |
Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study.
Topics: Aged; Albuminuria; Antihypertensive Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Doubl | 2004 |
Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes.
Topics: Aged; Albuminuria; Antihypertensive Agents; Diabetes Mellitus, Type 2; Enalapril; Female; Humans; Hy | 2007 |
Regression of microalbuminuria: results of a controlled study, indapamide versus captopril.
Topics: Aged; Albuminuria; Analysis of Variance; Blood Pressure; Captopril; Diabetes Mellitus, Type 2; Femal | 1993 |
Factors determining the blood pressure response to enalapril and nifedipine in hypertension associated with NIDDM.
Topics: Albuminuria; Aldosterone; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Glucose; Blood P | 1995 |
Comparative effects of indapamide and captopril on blood pressure and albumin excretion rate in diabetic microalbuminuria.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calc | 1996 |
Indapamide is as effective as captopril in the control of microalbuminuria in diabetes.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Cross-Ove | 1996 |
6 other studies available for indapamide and Albuminuria
| Article | Year |
|---|---|
[The challenge to treat hypertensive patients with type 2 diabetes].
Topics: Adult; Albuminuria; Antihypertensive Agents; Body Mass Index; Cardiovascular Diseases; Diabetes Mell | 2002 |
[Reflexion of French experts on the key points of the symposium].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; | 2002 |
[Vascular impact of anti-hypertensive treatment and renal protection].
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diuretics; Double-Bl | 2005 |
Regression of microalbuminuria in type II diabetic, hypertensive patients after long-term indapamide treatment.
Topics: Adult; Albuminuria; Blood Pressure; Diabetes Mellitus, Type 2; Glomerular Filtration Rate; Humans; H | 1991 |
Efficacy of antihypertensive treatment with indapamide in patients with noninsulin-dependent diabetes and persistent microalbuminuria.
Topics: Adult; Albuminuria; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies | 1990 |
Hypertension and micro-albuminuria in diabetic patients taking indapamide.
Topics: Aged; Aged, 80 and over; Albuminuria; Blood Pressure; Diabetes Mellitus; Diuretics; Drug Evaluation; | 1989 |