indacaterol has been researched along with Colorectal-Neoplasms* in 1 studies
1 other study(ies) available for indacaterol and Colorectal-Neoplasms
| Article | Year |
|---|---|
SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer.
To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6.. We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expression Omnibus (GEO) database. Functional analysis of SRSF6 in CRC was performed. SRSF6 was frequently upregulated in CRC samples and associated with poor prognosis, which promoted proliferation and metastasis. SRSF6 functions the important roles in mediating CRC progression through regulating AS, and indacaterol is repositioned as an antitumour drug through targeting SRSF6.. The accession numbers for sequencing data are SRP111763 and SRP111797. Topics: Alternative Splicing; Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Immunoprecipitation; Indans; Mice; Phosphoproteins; Protein Isoforms; Quinolones; Sequence Analysis, RNA; Serine-Arginine Splicing Factors; Tumor Cells, Cultured; Up-Regulation | 2019 |