incretins and Hepatitis-C--Chronic

Metabolic disorders are common in patients with chronic hepatitis C virus (HCV) infection. Epidemiologic and clinical data indicate an overprevalence of lipids abnormalite, steatosis, insuline resistance (IR) and diabetes mellitus in HCV patients, suggesting that HCV itself may interact with glucido-lipidic metabolism. HCV interacts with the host lipid metabolism by several mechanisms leading to hepatic steatosis and hypolipidemia which are reversible after viral eradication. Liver and peripheral IR are HCV genotype/viral load dependent and improved after viral eradication. This article examines examine the relationship between HCV, lipid abnormalities, steatosis, IR, and diabetes and the pathogenic mechanisms accounting for these events in HCV-infected patients.

Topics: Animals; Cytokines; Diabetes Mellitus, Type 2; Dyslipidemias; Fatty Liver; Hepacivirus; Hepatitis C, Chronic; Humans; Incretins; Insulin Resistance; Insulin-Secreting Cells; Lipid Metabolism; Mice; Prevalence; Risk Factors; Signal Transduction

Topics: Animals; Chronic Disease; Dipeptidyl Peptidase 4; Glucagon-Like Peptide 1; Glucose Intolerance; Hepatitis C, Chronic; Humans; Incretins; Liver Diseases