incretins and Esophageal-Neoplasms

incretins has been researched along with Esophageal-Neoplasms* in 1 studies

Trials

1 trial(s) available for incretins and Esophageal-Neoplasms

ArticleYear
Combining enteral with parenteral nutrition to improve postoperative glucose control.
    The British journal of nutrition, 2010, Volume: 103, Issue:11

    The provision of parenteral nutrition (PN) to 'stressed' patients often results in hyperglycaemia, which may be detrimental. In animal models limited amounts of enteral nutrition (EN) improve intestinal integrity and stimulate intestinal incretin production, which may lead to improved glucose control. We set out to assess if combining EN with PN results in improved glucose homeostasis rather than PN given alone. We conducted a randomised trial in a university teaching hospital of patients undergoing a 'curative' oesophagectomy for adenocarcinoma. Differences between the two intervention groups were assessed for continuous glucose measurement, insulin sensitivity using insulin tolerance tests (ITT) and homeostasis model analysis (HOMA), the incretin glucose-dependent insulinotropic polypeptide (GIP) and intestinal permeability. The combination of PN with EN resulted in lower interstitial glucose concentrations (P = 0.002), reduced insulin resistance, improved insulin sensitivity (HOMA-insulin resistance (IR) P = 0.045; HOMA beta P = 0.037; ITT P = 0.006), improved intestinal permeability (P < 0.001) and increased GIP (P = 0.01) when compared with PN alone. The combination of EN with PN, when compared with PN alone, results in reduced glucose concentrations, reduced insulin resistance, increased incretins and improvements in intestinal permeability.

    Topics: Adenocarcinoma; Aged; Blood Glucose; Enteral Nutrition; Esophageal Neoplasms; Esophagectomy; Female; Homeostasis; Humans; Incretins; Insulin; Insulin Resistance; Intestinal Absorption; Male; Middle Aged; Parenteral Nutrition; Postoperative Care

2010