incretins has been researched along with Bone-Diseases* in 1 studies
1 other study(ies) available for incretins and Bone-Diseases
| Article | Year |
|---|---|
[Role of incretins in the regulation of bone metabolism].
Diabetes is associated with increased risk of osteoporosis. Gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide(GIP) and glucagon-like peptide-1 (GLP-1) are incretin hormones released upon meal ingestion, and GIP and/or GLP-1 signaling is decreased in diabetic state. We have demonstrated that both GIP receptor knockout mice and GLP-1 receptor knockout mice have osteoporosis. GIP has anabolic effects on bone mainly by stimulating osteoblastic bone formation through intermittent elevation of intracellular cAMP levels. On the other hand, GLP-1 is suggested to regulate bone resorption indirectly through the thyroid C cell. Our studies show that incretins play important roles in bone metabolism by distinct mechanisms. Topics: Animals; Bone and Bones; Bone Diseases; Diabetes Complications; Incretins; Mice; Mice, Knockout | 2011 |