incb3344 and Polycystic-Kidney--Autosomal-Dominant

In patients with autosomal dominant polycystic kidney disease (ADPKD), most of whom have a mutation in. To define the role of Mcp1 and macrophages in promoting cyst growth, we used mice with inducible knockout of. In single-knockout mice, upregulation of. Mcp1 is upregulated after knockout of

Topics: Animals; Chemokine CCL2; Disease Models, Animal; DNA Damage; Humans; Kidney Tubules; Macrophage Activation; Macrophages; Male; Mice; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Pyrrolidines; Reactive Oxygen Species; Receptors, CCR2; TRPP Cation Channels; Up-Regulation