incb3344 has been researched along with Diabetic-Nephropathies* in 1 studies
1 other study(ies) available for incb3344 and Diabetic-Nephropathies
| Article | Year |
|---|---|
Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy.
The pathogenesis of diabetic nephropathy (DN) is related to macrophage (Mφ) recruitment to the kidneys, tumor necrosis factor-α (TNF-α) production, and oxidative stress. Toll-like receptor 9 (TLR9) activation is reportedly involved in systemic inflammation, and it exacerbates this condition in metabolic syndrome. Therefore, we hypothesized that TLR9 plays a role in the pathogenesis of DN. Two subsets of kidney Mφs in DN model ( Topics: Animals; Diabetic Nephropathies; Disease Models, Animal; Kidney; Macrophages; Male; Mice, Inbred C57BL; Mice, Knockout; Phagocytosis; Phenotype; Pyrrolidines; Reactive Oxygen Species; Receptors, CCR2; Receptors, Leptin; Signal Transduction; Toll-Like Receptor 9; Tumor Necrosis Factor-alpha | 2021 |