imiquimod has been researched along with Psoriasis in 709 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (0.99) | 29.6817 |
| 2010's | 336 (47.39) | 24.3611 |
| 2020's | 366 (51.62) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, C; Dai, L; Liu, J; Liu, L; Pan, Y; Sui, Q; Sun, H; Sun, L; Wen, X; You, Y; Yuan, H | 1 |
| Abbas, H; Elgewelly, MA; Elmasry, SM; Sayed, NSE | 1 |
| Kong, L; Li, M; Lv, W; Meng, S; Qiao, H; Song, C; Sun, Y; Wang, X; Yang, C; Zhu, Y | 1 |
| Chen, S; Chen, X; Lin, Z; Xi, L; Zheng, Y; Zhou, Q | 1 |
| Amento, E; Kang, GJ; Kaur, M; Mechanic, J; Ravikumar, P; Welihinda, A; Yadav, S | 1 |
| Gao, J; Li, X; Ma, X; Miao, Y; Wei, W; Xi, B; Yang, C; Zhang, J; Zhou, H | 1 |
| Egawa, S; Ito, M; Kamata, M; Mizukawa, I; Shimizu, T; Tada, Y; Takeshima, R; Uchida, H; Watanabe, A | 1 |
| Chen, C; Duan, Q; Liu, M; Shao, Y; Sun, Q; Wang, M; Wang, Y; Zhang, M; Zheng, Y | 1 |
| Asahina, R; Chow, Z; Dainichi, T; Egawa, G; Ishida, Y; Kabashima, K; Kitoh, A; Miyake, T; Nomura, T; Okuno, T; Otsuka, M; Yokomizo, T | 1 |
| Chitkara, D; Mittal, A; Pukale, SS | 1 |
| Chen, S; Chen, X; Cheng, H; Hua, C; Lai, L; Song, Y; Wu, X; Xu, Y; Zhu, J | 1 |
| Abdollahifar, MA; Dehpour, AR; Haddadi, NS; Hedayatyanfard, K; Kazemi, K; Shayan, M; Shokrian Zeini, M; Solaimanian, S | 1 |
| Hu, Z; Huang, N; Li, J; Liu, X; Ma, T; Wang, Z; Wei, X; Wu, W; Zhang, J; Zhen, H; Zhou, H | 1 |
| Bassaganya-Riera, J; Chauhan, J; Hontecillas, R; Leber, A; Maturavongsadit, P; Tubau-Juni, N | 1 |
| Bai, Q; Chan, CKW; Choi, CHJ; Choi, PC; Han, R; Ho, LWC; Lee, LKC | 1 |
| Alalaiwe, A; Chang, ZY; Chen, CY; Chuang, SY; Fang, JY; Sung, JT | 1 |
| Baek, JO; Jun, HS; Kim, D; Kim, HJ; Roh, JY | 1 |
| Choi, YA; Jang, YH; Jeong, GS; Kang, J; Kim, N; Kim, SH; Lee, S | 1 |
| Kang, J; Khang, D; Kim, N; Kim, SH; Kwon, TK; Lee, S | 1 |
| Chen, C; Chen, X; Chen, Z; Dou, X; Huang, C; Huang, H; Huang, X; Jian, X; Jiang, B; Li, Z; Liu, X; Ren, X; Shen, C; Yang, L; Yu, B; Zhong, W | 1 |
| Vinardell, MP | 1 |
| Albanesi, C; Madonna, S; Mercurio, L; Morelli, M; Pallotta, S; Scaglione, GL; Scarponi, C | 1 |
| Fang, H; Li, C; Lu, Z; Ma, L; Shao, S; Wang, G; Xue, K | 1 |
| Abdellatif, AAH; Abdulmonem, WA; Al Rugaie, O; Alhumaydhi, FA; Aljasir, M; Aljohani, ASM; AlKhowailed, MS; Alnuqaydan, AM; Alsagaby, SA; Alsuhaibani, SA; Alwashmi, ASS; Babiker, AY; Elsheikh, SY; Hegazy, AMS; Mousa, AM; Seleem, HS; Soliman, KEA; Yosof, MYR | 1 |
| Iida, K; Ishikawa, J; Iwamoto, T; Iwata, A; Kageyama, T; Makita, S; Nakajima, H; Suto, A; Suzuki, K; Tanaka, S; Yabe, Y; Yokota, M | 1 |
| Blauvelt, A; Boki, H; Kimura, T; Miyagaki, T; Okochi, H; Sato, S; Suga, H; Sugaya, M | 1 |
| Jiang, J; Kuai, L; Li, B; Li, X; Liu, T; Luo, Y; Ru, Y; Song, J; Sun, X; Xing, M; Zhang, H | 1 |
| Bocheńska, K; Gabig-Cimińska, M; Moskot, M | 1 |
| Cheng, G; Kuang, H; Su, Y; Wang, Q; Wu, L; Zhang, F | 1 |
| Chen, Y; He, Y; Li, W; Ma, Y; Shangguan, Y; Zhao, Y | 1 |
| Alalaiwe, A; Chuang, SY; Fang, JY; Huang, TH; Lin, CF; Nguyen, TMH; Wang, PW | 1 |
| Di, T; Fu, J; Guo, J; Guo, X; Li, P; Liu, Q; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J | 1 |
| Deng, M; Li, S; Li, X; Luo, S; Su, Y; Tan, S; Tang, G; Wu, R; Zhang, P; Zhang, Q; Zhang, S; Zhang, X; Zhao, M; Zhu, Y | 1 |
| Chen, D; Gao, J; Guo, W; Jiang, X; Ke, B; Lai, Y; Ma, H; Shao, F; Sun, Y; Wu, Z; Xu, Q; Yan, W; Zhu, Y | 1 |
| Gangwar, RS; Gudjonsson, JE; Ward, NL | 1 |
| Chen, Z; Di, T; Li, P; Lv, J; Wang, Y; Xu, J; Yang, H; Zhou, T | 1 |
| Cao, G; Cao, Z; Liu, Z; Shi, Y; Sun, R; Xu, Q; Yang, N; Zhang, C | 1 |
| Chen, ZX; Di, TT; Li, P; Liu, Y; Liu, ZR; Meng, YJ; Wang, Y; Zhao, JX | 1 |
| Bai, J; Bao, L; Cai, X; Jiang, B; Li, Q; Li, X; Lou, F; Song, N; Sun, L; Sun, Y; Tang, S; Wang, B; Wang, H; Wang, Z; Wu, Y; Yin, Q; Yu, B; Zhou, H | 1 |
| Chen, X; Li, B; Li, HJ; Li, W; Li, X; Liu, L; Lu, Y; Sun, XY; Ze, K; Zhou, YQ | 1 |
| Alarcón-Riquelme, ME; Castillejo-López, C; Coppard, C; Gómez-Hernández, G; Kumar, R; Luque, MJ; Marañón, C; Martín-Morales, N; Morell, M; O'Valle, F; Pérez-Cózar, F; Varela, N; Wu, YY | 1 |
| Han, D; Li, F; Lu, S; Meng, L; Mou, K; Wang, B; Xu, J; Zhang, W; Zhao, Y; Zhou, Y; Zhu, W | 1 |
| Bayik, D; Braley, C; Chandrasekharan, UM; de Windt, N; DiCorleto, PE; Fernandez, AP; Harvey, JE; Hsieh, J; Husni, ME; Jaini, R; Kaur, R; Lee, M; Rai, V; Scheraga, RG | 1 |
| Chen, J; Dang, E; Fang, H; Li, Q; Ma, J; Pang, B; Qiao, H; Qiao, P; Shao, S; Sun, Z; Wang, G; Wang, L; Xue, K; Yu, C | 1 |
| Du, JC; Han, X; Liu, XH; Yan, Y; Zhang, F; Zhu, R | 1 |
| Chen, N; Li, L; Tian, C; Xia, Z; Yang, S; Zhang, G | 1 |
| Cui, J; Li, W; Sun, H; Zhai, S; Zhang, P; Zhao, Y | 1 |
| Jun, L; Kun, X; Lu, L; Pin, C; Wei, C; Xiangjin, X; Xiaohong, L; Xin, L; Yunjie, Y; Zhenting, Z | 1 |
| Choi, MJ; Nguyen, LTH; Shin, HM; Yang, IJ | 1 |
| Lin, X; Liu, Q; Qian, J; Tang, J; Xie, Q; Xiong, S; Zhou, Z | 1 |
| Guo, H; Li, M; Liu, H | 1 |
| Ma, X; Mao, J; Zhang, H; Zhu, J | 1 |
| Aljuffali, IA; Fang, JY; Huang, JR; Lin, CF; Tseng, CH; Yang, SH | 1 |
| Cichy, J; Grygier, B; Kapinska-Mrowiecka, M; Kwiecinska, P; Kwitniewski, M; Majchrzak-Gorecka, M; Morytko, A; Porebski, G; Sanecka-Duin, A | 1 |
| Cheng, H; Du, X; Li, M; Mei, X; Pan, Y; Tian, D; Yang, L; Zhang, D | 1 |
| Chen, Y; Cui, L; Dai, X; Gu, J; Guo, C; Shi, Y; Xu, H; Yu, Q; Yu, Y; Yu, Z; Zhang, X | 1 |
| Chung, JH; Jo, SJ; Kim, EJ; Kim, SJ; Kim, TG; Lee, Y; Ohn, J; Suh, JH | 1 |
| Chen, Y; Chen, Z; Guo, C; Hu, Y; Shi, Y; Wang, Y; Xu, P; Yu, Q; Yu, Z; Zhang, X; Zhao, Z; Zhou, X | 1 |
| Agostini, SBN; Alves, CO; Bernardes, MTCP; Carvalho, FC; da Silva, LP; Gonçalves, RV; Novaes, RD; Pereira, GR | 1 |
| Chen, S; Chen, X; He, T; Islam, MS; Liao, P; Lin, Z; Xi, L; Yang, Y; Zheng, Y | 1 |
| Cha, X; Chen, Y; Lai, B; Tao, T; Wang, J; Wang, W; Xiao, W | 1 |
| Rasool, M; Srikanth, M | 1 |
| Cheng, LY; Deng, Y; Feng, XY; Guo, DJ; Guo, WJ; Hua, L; Li, FL; Liu, X; Wang, Y; Xi, RF; Ze, K; Zhu, JY; Zhu, SJ | 1 |
| Dang, N; Fan, H; Huang, S; Li, X; Liu, N; Ma, G; Qin, L; Wang, J; Yang, T; Zhang, P | 1 |
| Chen, ZX; Di, TT; Feng, F; Hu, XQ; Li, P; Meng, YJ; Qi, C; Wang, Y; Wang, YZ; Zhao, JX | 1 |
| Fang, X; Li, W; Ling, S; Liu, X; Luo, Y; Wang, A; Xu, B; Yao, X; Zhang, S; Zhou, Y; Zong, W | 1 |
| Im, DS; Koh, JM; Son, SE | 1 |
| Bonifaz, LC; Cancino-Diaz, JC; Cancino-Diaz, ME; Castro-Escamilla, O; Martínez-Torres, I; Perez-Tapia, SM; Rodríguez-Martínez, S; Tepale-Segura, A | 1 |
| Du, Z; Gu, H; Huang, J; Li, C; Liu, G; Shi, Y; Xu, Y; Zhang, L; Zhou, W | 1 |
| Alani, R; Ali, D; Ardianto, C; Ayoub, R; Goh, KW; Jarrar, Q; Jilani, J; Moshawih, S | 1 |
| Goto, H; Habe, K; Iida, S; Kondo, M; Matsushima, Y; Naka, M; Nakai, Y; Nishii, M; Yamanaka, K | 1 |
| Ahmad, SF; Al-Harbi, NO; Alanazi, AZ; Alasmari, F; Alharbi, M; Alhazzani, K; Almutairi, M; Alqahtani, F; Alqarni, SA; Ibrahim, KE; Nadeem, A | 1 |
| Bieler, T; Daiber, A; Karbach, S; Keller, K; Knopp, T; Kropp, A; Lagrange, J; Molitor, M; Münzel, T; Rauh, M; Ringen, J; Sies, K; Titze, J; Waisman, A; Wenzel, P; Wild, J | 1 |
| Fu, FH; Li, XX; Lin, YW; Liu, B; Ma, L; Qi, R; Xing, X | 1 |
| Correa Atella, G; Donato-Trancoso, A; Romana-Souza, B | 1 |
| Adachi, A; Egawa, G; Gunzer, M; Honda, T; Hossain, MR; Ikuta, K; Kabashima, K; Kanameishi, S; Komine, M; Miyake, T; Ohtsuki, M; Takimoto, R | 1 |
| Bansal, AK; Parmar, PK; Rohit, A; Sharma, N; Wasil Kabeer, S | 1 |
| Chen, LC; Cheng, YP; Guo, JW; Liu, CY | 1 |
| Cho, H; Hwang, ES; Je, JH; Jeon, Y; Jeong, MG; Kang, J; Lee, K; Song, J | 1 |
| Chen, XY; Landeck, L; Man, XY; Wang, P; Wang, ZY; Xu, F; Yan, BX; Zheng, M; Zhou, Y | 1 |
| Chen, Z; Hu, L; Lei, X; Li, S; Liu, J; Liu, Y; Song, Z; Wei, Z; Xiang, R; Yang, Y | 1 |
| Guo, M; Lai, R; Lei, Q; Xian, D; Xian, L; Xu, J; Yang, Y; Zhao, Y; Zhong, J | 1 |
| Dashti, M; Haghnnavaz, N; Moghadam, M; Pordel, S; Rezaee, M; Sankian, M; Shobeiri, SS | 1 |
| Chen, X; Kuang, Y; Li, J; Liu, N; Liu, P; Peng, C; Yan, B; Yi, X; Zhu, W | 1 |
| Chen, P; Li, X; Shao, Z; Xu, X | 1 |
| Chen, Y; Li, X; Song, S; Wang, Y; Zhu, J | 1 |
| Cai, Y; Chen, L; Ding, C; Hu, X; Li, X; Liu, N; Qin, H; Rouchka, EC; Tieri, D; Wang, L; Xu, Q; Xue, F; Yan, J; Zheng, J | 1 |
| Arakawa, Y; Arita, T; Asai, J; Katoh, N; Masuda, K; Nakamura, K | 1 |
| Abe, T; Hida, T; Ichimiya, S; Ikegami, I; Inoue, KI; Kamada, Y; Kamekura, R; Kamiya, S; Kamiya, T; Kobayashi, K; Sato, T; Takaki, H; Uhara, H; Yanagi, M | 1 |
| Cui, K; Gu, L; Hao, Y; Hu, J; Hu, Y; Hu, Z; Huang, N; Li, J; Li, W; Liu, X; Luo, F; Wang, X; Wang, Z; Wei, X; Wu, W; Yu, J; Yue, C; Zeng, F; Zhang, C; Zhao, F; Zhao, Q; Zheng, H; Zhou, H; Zhou, P; Zhou, Y | 1 |
| Chen, X; Chen, Y; Hu, W; Hua, L; Liang, S; Ou, Y; Sun, P; Wu, X; Yang, X; Yang, Z; Yue, H; Zhou, Y | 1 |
| Bai, Y; Cao, L; Chen, S; Chen, W; Fan, W; Ge, H; Li, B; Li, Z; Liu, M; Luo, S; Mao, Y; Shen, J; Sun, L; Wang, D; Wang, Y; Yong, L; Yu, Y; Zhang, C; Zhang, R; Zhen, Q | 1 |
| Chen, Z; Gao, WQ; Hao, W; Lin, J; Tang, J; Wang, L; Xu, H; Yang, M; You, Q; Zhao, X | 1 |
| Wu, X; Xiang, S; Xiang, Y | 1 |
| Di, T; Feng, F; Hu, X; Li, P; Meng, Y; Qi, C; Wang, Y; Zhang, X; Zhao, J; Zhao, N | 1 |
| Daien, CI; King, NJC; Macia, L; Mielle, J; Moore, RJ; Ni, D; Pinget, GV; Simpson, S; Stanley, D; Taitz, J; Tan, JK | 1 |
| Chen, J; He, L; Liu, L; Niu, Y; Qi, H; Qin, S; Yu, S | 1 |
| Cai, H; Chen, X; Chen, Y; Hu, W; Hua, L; Liang, S; Lin, G; Liu, Z; Ou, Y; Sun, P; Wu, X; Yang, Z; Zhou, Y | 1 |
| AAl-Haidari, R; Ah Mostafa, M; Alhaddad, A; N Al Busaidi, H; Samman, W; Samuel Kelechi, M; Sarkar, D; Sm, F | 1 |
| Bhardwaj, P; Gupta, R; Pandey, S; Ramchandra Patil, P; Tripathi, P | 1 |
| He, L; Li, C; Li, M; Qiao, P; Shao, S; Wang, G; Wang, Z; Zhang, J; Zhang, K; Zhang, Y | 1 |
| Huang, C; Huang, F; Li, B; Lin, D; Wang, S; Xu, C; Zhang, T | 1 |
| Carlos, ECDS; Cristovão, GA; Ribeiro, BCS; Romana-Souza, B; Silva, AA | 1 |
| Li, M; Liu, C; Liu, S; Lu, J; Tang, J; Zhou, X; Zhu, L | 1 |
| Jiang, C; Li, H; Qi, Q; Zhou, Y; Zou, W | 1 |
| Dai, C; Guo, X; Jiang, F; Wang, J; Wu, X; Yin, Q | 1 |
| Chen, Y; Chikazawa, S; Ichimasu, N; Katagiri, K; Kobayashi, K; Suzuki, S | 1 |
| Hou, JJ; Jia, HY; Qiu, HY; Wu, Y; Zhang, MD; Zhou, ML | 1 |
| Gu, J; Shi, Y; Wang, H; Yao, L; Yu, Q; Zhang, X; Zhao, Z | 1 |
| Huang, J; Jin, H; Wang, Y | 1 |
| Bai, D; Cheng, X; Hao, J; Li, Q; Lu, F; Sun, T; Zhang, B; Zhang, Y | 1 |
| Chen, J; Chen, R; Jin, N; Li, Y; Zhang, B; Zhang, Z | 1 |
| Li, W; Yang, C; Yang, W | 1 |
| Duan, J; Duan, R; Gao, S; Li, J; Li, X; Ma, X; Qin, Y; Shi, R; Zhang, L; Zhao, R | 1 |
| Huo, R; Li, H; Shen, B; Sheng, H; Shu, J; Sun, H; Sun, Y; Zhai, T; Zhang, J | 1 |
| Li, H; Wang, J; Wang, S; Xiong, Y; Zhou, X | 1 |
| Chen, H; Ge, W; Huang, Y; Jiang, J; Jin, Z; Kong, Y; Li, F; Li, L; Li, M; Liu, X; Zeng, X; Zhanmu, O | 1 |
| Chen, JQ; Chen, XY; Cui, YZ; Fu, NC; Landeck, L; Man, XY; Wang, ZY; Xu, F; Yan, BX; Yang, XY; Zhou, Y | 1 |
| Abram, CL; Bevilacqua, D; Cassatella, MA; Caveggion, E; Cestari, T; Constantin, G; Costa, S; De Sanctis, F; Donini, M; Dusi, S; Gasperini, S; Girolomoni, G; Lonardi, S; Lowell, CA; Pettinella, F; Rodegher, P; Scapini, P; Tagliaro, F; Ugel, S; Vermi, W; Zenaro, E | 1 |
| Cui, H; Guo, H; Li, S; Li, X; Li, Y; Li, Z; Nandakumar, KS | 1 |
| Asaji, M; Chang, J; Hattori, H; Higo, T; Hikoso, S; Ichi, I; Inui, H; Ito, K; Kamada, Y; Kanno, K; Koseki, M; Nishida, M; Nishihara, S; Ohama, T; Okada, T; Okuzaki, D; Omatsu, T; Ono, M; Saga, A; Saibara, T; Sakata, Y; Tanaka, K; Yamashita, S; Zhu, Y | 1 |
| Chen, C; Chen, M; Chen, X; Hou, G; Kuang, Y; Li, J; Li, L; Lin, L; Liu, P; Peng, C; Su, J; Yan, B; Zhu, W | 1 |
| Chenyang, W; Fushida, N; Hamaguchi, Y; Horii, M; Ikawa, Y; Kitano, T; Komuro, A; Matsushita, T; Nakabori, I; Sawada, K; Xibei, J | 1 |
| Dong, BQ; Jiang, S; Lei, TC; Liao, ZK; Luo, LF; Miao, F; Yao, YZ | 1 |
| Bhavana, V; Chary, PS; Mehra, NK; Pardhi, E; Singh, SB; Sulthana, S | 1 |
| Bai, M; Deng, H; Fan, X; Guo, M; Li, Z; Liu, W; Meng, Q; Shi, Y; Sun, R; Yang, X; Yuan, D | 1 |
| Li, K; Nandakumar, KS; Ou, J; Wang, T; Wu, H | 1 |
| Kim, J; Kim, KI; Lee, A; Lim, JS; Park, KC | 1 |
| Chen, H; Huang, Y; Jiang, J; Jin, Z; Kong, Y; Li, L; Liu, X; Tong, Q; Wei, F; Yin, J; Zhang, Y | 1 |
| Banfi, G; Casciano, F; Gornati, L; Granucci, F; Guerrini, R; Marzola, E; Mingozzi, F; Montico, G; Protti, G; Reali, E; Secchiero, P; Volinia, S | 1 |
| Cai, Z; Shi, X; Wang, W; Zeng, Y; Zhang, X; Zhu, H | 1 |
| Lian, LH; Nan, JX; Wu, YL; Yang, HX; Zhan, ZY; Zhang, ZH | 1 |
| Christensen, PKF; Hansen, AK; Høyer-Hansen, MH; Koch, J; Larsen, J; Martel, BC; Skov, S | 1 |
| Jiang, D; Li, J; Lyu, Y; Wu, D; Xin, X; Yang, L; Yin, L; Zhou, Y; Zhu, Y | 1 |
| Cheng, G; Jin, S; Liu, W; Mi, R; Pan, W; Piao, H; Zou, M | 1 |
| Clausen, BE; Hsiao, YP; Kelel, M; Lee, CH; Lee, YL; Liang, PH; Liu, FT; Lu, CH; Su, SH; Tan, YF; Tsai, CH; Tsai, TF; Weng, HJ; Yeh, CY | 1 |
| Hartmann, JN; Häsler, R; Philippsen, R; Piticchio, SG; Rose-John, S; Schwarz, A; Schwarz, T | 1 |
| Chen, H; Chen, K; Hu, Y; Huang, D; Ju, M; Liu, L; Luan, C; Zhang, J; Zhou, X | 1 |
| Ando, M; Fukuyama, T; Iwashita, N; Kushiro, M; Takagi, Y; Yamaguchi, H | 1 |
| Che, D; Hang, B; Li, K; Li, Y; Wang, H; Wang, K | 1 |
| Li, H; Li, X; Lin, N; Liu, L; Lu, Y; Luo, D; Sun, X; Wang, J; Yin, C; Zhang, M; Zhou, Y | 1 |
| Egusa, C; Harada, K; Hayakawa, K; Maeda, T; Okubo, Y | 1 |
| Chen, X; Lei, Y; Liu, Y; Lyu, C; Yang, Y; Ye, Y; Zhang, T; Zhou, X | 1 |
| Chodaczek, G; Kupczyk, P; Makarec, A; Makuch, S; Woźniak, M; Ziółkowski, P | 1 |
| Chang, YC; Chen, CH; Chen, PJ; Chen, SH; Fang, SY; Hwang, TL; Tsai, SC; Tsai, YF; Tseng, HH; Wang, YH | 1 |
| Cheng, D; Dong, G; Li, C; Liu, C; Shi, D; Wang, C; Wei, L; Xiong, H; Yan, F; Yang, Z; Zhang, H; Zhang, J; Zhang, Y | 1 |
| Benoist, C; Hanna, BS; Hsu, YC; Mathis, D; Ortiz-Lopez, A; Sassone-Corsi, M; Shwartz, Y; Zarin, P | 1 |
| Choi, JH; Jung, SY; Kim, DW; Lee, KA; Park, S; Park, SH | 1 |
| Hillman, PF; Jung, YR; Kang, JH; Kang, TB; Kim, JH; Lee, SB; Nam, SJ; Sim, EJ | 1 |
| Chen, X; He, Y; Huang, X; Jia, H; Liu, T; Shan, W; Sun, R; Yang, Q | 1 |
| Abdallah, OY; Atia, NM; El-Aal, SAA; Ibrahim, SSA; Reda, AM; Shahine, Y; Sheta, E | 1 |
| Chen, C; Chen, M; Chen, X; Kuang, Y; Li, J; Li, L; Liu, P; Peng, C; Su, J; Yan, B; Zhou, Y; Zhu, W | 1 |
| Cao, YC; Cui, WY; Kong, SM; Sun, XY | 1 |
| Chen, X; Chu, C; Han, J; Huang, X; Li, X; Lin, Z; Wang, F; Xiong, Y; Xu, R | 1 |
| Bang, J; Bareja, R; Desman, G; Ding, W; Elemento, O; Eljalby, M; Granstein, RD; Miller, LS; Reilly, MD; Vyas, NS; You, J; Yusupova, M; Zippin, JH | 1 |
| Hu, Y; Huang, K; Huang, Q; Huang, W; Li, Q; Weng, D; Xu, W; Yao, S; Zheng, X; Zhou, C | 1 |
| Li, G; Li, L; Li, S; Li, X; Wu, F | 1 |
| Cai, X; Du, J; Gao, W; Gong, H; Lu, H; Xiao, H; Xu, J; Yang, Y | 1 |
| Liu, Q; Ren, C; Wang, D; Wang, Q; Zhang, H | 1 |
| Jiang, Y; Lai, Y; Lu, S; Wang, L | 1 |
| Al Rudaisat, M; Amanullah, M; Chen, S; Chen, X; Cheng, H; Hua, C; Liang, Q; Song, Y; van der Veen, S; Wang, X; Zhou, C | 1 |
| Amalia, SN; Baral, H; Fujiwara, C; Hosoi, M; Inoue, Y; Ishikawa, M; Kosaka, K; Motegi, SI; Ogino, S; Sekiguchi, A; Shibasaki, K; Torii, R; Uchiyama, A; Yamazaki, S; Yokoyama, Y | 1 |
| Dai, SM; Deng, H; Guo, M; Liu, N; Liu, W; Meng, Q; Su, Y; Wei, M; Zhuang, H | 1 |
| Lin, J; Lin, P; Lu, YY; Shi, HY | 1 |
| Chen, S; Ding, K; Huang, H; Huang, T; Lv, W; Ma, S; Rong, Z; Wang, X; Yang, B; Zhang, X; Zheng, B; Zhong, Y | 1 |
| Feng, S; Guo, D; Guo, T; Li, A; Li, S; Li, Y; Wang, B; Wang, Q; Yin, S | 1 |
| Han, X; Li, P; Lin, Y; Liu, X; Xie, X; Zhang, L | 1 |
| Fu, D; Fu, X; Hu, H; Li, J; Li, M; Song, X; Tian, Z; Wang, Q; Yan, D; Yang, Z; Zheng, S | 1 |
| Li, L; Liu, J; Tian, C; Xia, A; Xia, Z; Yang, S; You, J; Zhang, G | 1 |
| Luo, F; Luo, M; Pan, Y; Peng, Y; Ran, C; Wang, B; Wang, H; Wang, L; Yan, YN; Yi, T; Zhang, Y; Zhou, R | 1 |
| Antal, D; Bai, P; Demény, MÁ; Dull, K; Kiss, B; Kovács, I; Póliska, S; Pór, Á; Szántó, M; Szegedi, A; Szöllősi, AG; Ujlaki, G | 1 |
| An, B; Hong, N; Kong, Q; Liu, F; Sang, H; Shan, Y; Wu, Y; Yu, P; Zhang, X | 1 |
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| Dong, P; Feng, J; Hu, Q; Li, D; Li, J; Liu, D; Liu, S; Shen, R; Sun, J; Tao, W; Wan, H; Yan, Y; Zhang, F; Zhang, L; Zhang, R | 1 |
| Chung, BY; Kang, SY; Kim, HO; Kim, HR; Kim, JC; Park, CW | 1 |
| Chang, SH; Chen, YL; Hsieh, PS; Hsieh, PW; Hwang, TL; Korinek, M; Wu, YH | 1 |
| Bae, EJ; Hao, L; Kwon, BM; Mao, Y; Park, BH; Park, J | 1 |
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| Cai, R; Gu, J; Li, N; Lu, C; Wei, H; Wu, D; Xie, F; Zhang, M | 1 |
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| Chen, H; Han, L; Ma, Y; Qiong, H; Xu, J; Yan, K; Zhang, N; Zhang, Z | 1 |
| Chang, L; Fujita, Y; Hashimoto, K; Hashimoto, Y; Ishima, T; Matsue, H; Shinno-Hashimoto, H; Wei, Y | 1 |
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| Cui, Q; Dang, E; Lai, B; Li, F; Luo, W; Wang, G; Wang, N; Xiao, L; Xie, X; Zheng, Y | 1 |
| Abdel-Mottaleb, MMA; Arafa, MG; El-Zaafarany, GM; Fereig, SA | 1 |
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| Chen, Z; Di, T; Li, P; Wang, Y; Zhai, C; Zhao, J | 1 |
| Chen, Z; Di, T; Guo, X; Han, L; Han, X; Li, P; Lu, C; Wang, Y; Zhao, J | 1 |
| Jensen, LE; Kilpatrick, LE; Sun, S | 1 |
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| Fujimoto, M; Fujisawa, Y; Ichimura, Y; Ishitsuka, Y; Kubota, N; Mizuno, S; Nakamura, Y; Okiyama, N; Saito, A; Takahashi, S; Tanaka, R; Watanabe, R | 1 |
| Chan, TC; Chang, WY; Huang, WC; Krueger, JG; Lee, MS; Tsai, TF | 1 |
| Ding, XJ; Jiang, JS; Kuai, L; Li, B; Li, W; Liu, L; Luo, Y; Ru, Y; Song, JK; Yin, SY; Zhang, Y | 1 |
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| Chen, Y; Geng, Y; Lai, S; Wang, J; Zhang, S; Zhou, T; Zhou, Y | 1 |
| Bagnato, VS; Bentley, MVLB; de Araujo, MM; Suzuki, IL | 1 |
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| Di, T; Li, N; Li, P; Lin, Y; Meng, Y; Wang, M; Wang, Y; Xie, X; Xu, X; Zhai, Y; Zhao, J | 1 |
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| Asano, Y; Miyagaki, T; Oka, T; Sato, S; Shibata, S; Sugaya, M; Takahashi, N; Takahashi, T | 1 |
| Bai, R; Bi, Z; Dong, Y; Dou, R; Li, D; Liu, Z; Mao, C; Su, W; Xiangfei, D; Yang, P; Yang, Y; Yuan, X | 1 |
| Chen, H; Han, L; Liu, H; Lu, C; Wang, M; Yan, Y; Zhao, H | 1 |
| Kamata, Y; Kosaka, R; Matsuda, H; Ogawa, H; Sakaguchi, A; Takahashi, N; Takamori, K; Tominaga, M; Umehara, Y | 1 |
| Ahmad, SF; Al-Harbi, NO; Attia, SM; El-Sherbeeny, AM; Fardan, AS; Ibrahim, KE; Nadeem, A | 1 |
| Li, P; Li, X; Lin, Y; Liu, W; Wang, Y; Xie, X; Zhang, L | 1 |
| Bürger, C; Diehl, S; Han, YY; Kaufmann, R; Lang, V; Ringel, C; Shirsath, N; Weigert, A; Wolf, P | 1 |
| Fuller, SJ; Geraghty, NJ; Mansfield, KJ; Sluyter, R; Watson, D | 1 |
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| Huo, R; Li, H; Li, N; Shen, B; Shen, Z; Wu, P; Xu, H | 1 |
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| Jeon, YJ; Kim, TY; Lee, JH; Sah, SK; Shin, J; Yang, HS | 1 |
| Cho, S; Jin, SP; Kim, MW; Koh, SJ; Lee, DH; Park, HS; Yoon, HS; Yu, DA; Yun, HT | 1 |
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| M, R; Mishra, A; P, R; Prabhu, S; Sivaprakasam, TO; Varma, SR | 1 |
| Böhm, B; Brüne, B; Burkhardt, H; Sadik, CD; Scholz, T; Weigert, A | 1 |
| Akiyama, T; Jensen, LE; Sakai, K; Sanders, KM; Yanushefski, KM; Yosipovitch, G; Youssef, MR | 1 |
| Brunner, SM; Ebner, S; Holub, BS; Kofler, B; Koller, A; Lang, R; Reitsamer, HA; Schwarzenbacher, D; Sternberg, F; Stockinger, J; Trost, A; Vidali, S | 1 |
| Korn, T; Muschaweckh, A; Petermann, F | 1 |
| Dainichi, T; Egawa, G; Honda, T; Kabashima, K; Kitoh, A; Kusuba, N; Miyachi, Y; Nakajima, S; Otsuka, A | 1 |
| Chuang, TH; Hsu, LC; Lai, CY; Lin, KI; Su, YW | 1 |
| Chao, YH; Chen, YH; Chen, YK; Chen, YZ; Li, YR; Lin, CC; Tsai, HY; Tsai, WH; Wu, CS | 1 |
| Abdelaziz, EZ; Bayomy, NA; Okasha, EF | 1 |
| Cao, J; Dang, E; Fu, M; Jin, B; Li, W; Liu, Y; Wang, G; Xiao, C; Yao, X; Zhang, C; Zhu, Z | 1 |
| Atenhan, A; Batra, R; Biedermann, T; Boehner, A; Eyerich, K; Eyerich, S; Franz, R; Garzorz-Stark, N; Groß, C; Groß, O; Haak, S; Jargosch, M; Krause, L; Lauffer, F; Mueller, NS; Roenneberg, S; Schmidt-Weber, CB; Theis, FJ; Thomas, J; Traidl-Hoffmann, C | 1 |
| Fluhr, JW; Gruber, AD; Hedtrich, S; Hönzke, S; Kleuser, B; Mundhenk, L; Ostrowski, A; Pischon, H; Radbruch, M; Schumacher, F | 1 |
| Haba, R; He, YY; Katsuki, N; Kubota, Y; Kushida, Y; Moriue, T; Nakai, K; Naruse, F; Nishiyama, F; Yoneda, K | 1 |
| Gao, Q; Liu, JH; Luo, DQ; Wang, F; Wu, HH; Zhao, YK | 1 |
| Panonnummal, R; Sabitha, M | 1 |
| Chen, FY; Cheng, HM; Ho, TY; Hsiang, CY; Li, CC; Liao, YF; Lo, HY | 1 |
| Adachi, A; Dainichi, T; Egawa, G; Ginhoux, F; Honda, T; Ikuta, K; Kabashima, K; Kitoh, A; Kunisawa, J; Nagatake, T; Nakamizo, S; Nomura, T; Otsuka, A | 1 |
| Bao, J; Jiang, ZH; Jin, HT; Li, C; Li, WF; Liu, HQ; Wang, AP; Wang, YM; Wei, JF | 1 |
| Chen, H; Duan, X; Gan, L; He, M; Hu, F; Liu, X; Ming, Z; Poorun, D; Wang, X; Xu, J; Zhang, S; Zhu, K | 1 |
| Kim, CH; Kim, HJ; Lee, MH; Lee, YS; Won, HR | 1 |
| Honda, T; Ishii, KJ; Kabashima, K; Kobiyama, K; Mizuguchi, K; Natsume-Kitatani, Y; Tanaka, M; Uchio-Yamada, K | 1 |
| Favot, L; Jégou, JF; Lecron, JC; Mcheik, J; Morel, F; Pohin, M; Silvain, C; Vasseur, P; Venisse, N | 1 |
| He, SJ; Li, H; Lin, ZM; Liu, YT; Ma, M; Qi, Q; Shen, YF; Tang, W; Yan, YX; Yang, XQ; Zhu, FH; Zuo, JP | 1 |
| Bu, DF; Cao, CX; Dang, NN; Han, YF; Jiang, ZX; Liu, FT; Man, XY; Meng, Z; Shi, ZR; Tan, GZ; Wang, L; Wei, KH; Zhang, YP | 1 |
| Chen, X; Cheng, L; Dai, L; Deng, H; Deng, J; Li, Y; Lin, Y; Mao, Y; Shi, G; Su, X; Wang, Y; Wei, Y; Yang, Y; Yu, D; Zhang, J; Zhang, S; Zhang, X; Zhang, Y | 1 |
| Kim, DS; Kim, HJ; Kim, SH; Kim, TG; Lee, M; Lee, MG; Park, JY | 1 |
| Fukushige, T; Hashiguchi, T; Higashi, Y; Ibusuki, A; Kanekura, T; Yamakuchi, M | 1 |
| Cai, SQ; Chen, JQ; Landeck, L; Li, W; Man, XY; Min, M; Wang, P; Yan, BX; Zheng, M | 1 |
| Chen, M; Chen, W; Chen, X; He, Y; Kuang, Y; Li, J; Liu, P; Su, J; Tao, J; Wang, H; Zhang, J; Zhao, S; Zhu, W | 1 |
| Dang, E; Fang, H; Han, C; Jin, L; Li, B; Qiao, H; Wang, G; Zhuang, Y | 1 |
| Cho, HJ; Hong, IK; Kim, H; Lee, SY; Nam, S; Yang, H | 1 |
| Araújo, MM; Arruda, C; Carvalho, T; Marcato, PD; Pivetta, TP; Simões, S | 1 |
| Feng, B; He, S; Li, C; Liu, B; Liu, H; Lu, C; Su, Z; Tang, L; Wang, X; Xu, F; Zhao, J; Zheng, G; Zheng, X; Zhu, W; Zhu, Y | 1 |
| Hou, Y; Sun, HX; Tian, H; Wang, R; Zhang, L; Zhao, Y; Zhu, L | 1 |
| Ma, L; Qi, R; Wang, Y; Xue, H; Yuan, L | 1 |
| Han, M; Hu, R; Huang, G; Li, H; Liu, H; Liu, X; Liu, Y; Otsu, K; Xiao, S; Zhao, W; Zheng, T | 1 |
| Chen, H; Duan, X; Gan, L; Jaypaul, H; Liu, N; Liu, X; Makamure, JT; Ming, Z; Wang, X; Zhang, S; Zhu, K | 1 |
| Kainoh, M; Koga, Y; Takahashi, T | 1 |
| Cardoso, RM; Hansen, PR; Madsen, M; Nielsen, LB; Pedersen, TX; van Eck, M | 1 |
| Bíró, T; Brain, SD; Gyömörei, C; Gyulai, R; Horváth, S; Kelemen, B; Kemény, Á; Kodji, X; Komlódi, R; Perkecz, A; Pintér, E; Sándor, Z; Sétáló, G; Szőke, É; Tóth, BI | 1 |
| Brüne, B; Kenner, L; Ringel, C; Schlederer, M; Shirsath, N; Tangermann, S; Wagner, K; Wolf, P | 1 |
| Chandrasekharan, UM; DiCorleto, PE; Harvey, J; Husni, ME; Lax, JE; Seifarth, FG; Tytell, M | 1 |
| Hu, R; Huang, G; Huang, J; Li, H; Liu, X; Xiao, S; Zhang, B; Zhao, W; Zheng, T | 1 |
| An, H; Dong, C; Lai, Y; Lee, YH; Liu, K; Lu, H; Shi, Y; Wang, X; Wu, Y; Xu, M; Zhang, J | 1 |
| Kim, SH; Kim, TG; Lee, JW; Lee, M; Lee, MG; Park, J | 1 |
| Honma, M; Igawa, S; Iinuma, S; Ishida-Yamamoto, A; Kishibe, M; Saito, N; Shibuya, T | 1 |
| Che, B; Chen, H; Dong, C; Du, Z; Jiang, H; Li, P; Li, Y; Liu, G; Liu, X; Tang, J; Tang, Y; Xu, Y; Zhang, K; Zhang, L; Zhou, W | 1 |
| Artym, J; Fiedorowicz, A; Jeleń, M; Kaleta-Kuratewicz, K; Kałas, W; Kochanowska, I; Kocięba, M; Kuropka, P; Kuryszko, J; Madej, JP; Morak-Młodawska, B; Pawlak, A; Pluta, K; Strządała, L; Zaczyńska, E; Zimecki, M | 1 |
| Adachi, A; Arita, M; Dainichi, T; Egawa, G; Hanakawa, S; Honda, T; Kabashima, K; Kitoh, A; Kusuba, N; Miyachi, Y; Murata, T; Nakajima, S; Nakashima, C; Narumiya, S; Ono, S; Otsuka, A; Sawada, Y; Ueharaguchi, Y | 1 |
| Hung, CF; Lee, GA; Li, HJ; Wu, NL | 1 |
| Chao, YH; Chu, CL; Lee, YR; Lin, CC; Lin, FC; Pan, YG; Wu, JJ | 1 |
| Cheng, H; Gao, J; Liang, B; Liu, L; Shen, S; Sheng, Y; Shi, Y; Sun, L; Tang, H; Tang, X; Wang, W; Wen, L; Yang, C; Yang, S; Yin, X; Zhang, A; Zhang, X; Zheng, X; Zhou, F; Zhu, C; Zhu, Z; Zuo, X | 1 |
| Elizei, SS; Ghahary, A; Ghoreishi, M; Kilani, R; Mahmoudi, S; Pakyari, M | 1 |
| Chen, L; Liu, W; Ning, J; Shen, Y; Sun, Y; Wang, M; Wang, T; Wang, Y; Zhang, F | 1 |
| Bigas, J; Boix, J; Carceller, E; Pérez, P; Sevilla, LM | 1 |
| Chung, SH; Hashiguchi, Y; Iwakura, Y; Kubo, S; Matsue, H; Matsuo, K; Murayama, MA; Nakamura, Y; Saijo, S; Yabe, R; Yoshida, K | 1 |
| Di, TT; Li, P; Lin, Y; Meng, YJ; Wang, MX; Wang, N; Wang, Y; Xie, XJ; Xu, XL; Zhang, L; Zhao, JX | 1 |
| Carey, CD; Diaz-Perez, JA; Falo, LD; Killeen, ME; Mathers, AR; Yang, Y | 1 |
| Chen, C; Duan, Q; Liu, J; Liu, Z; Shao, Y; Wang, X; Wu, N; Yang, H; Yang, P; Zhang, M; Zheng, Y | 1 |
| Fukami, S; Kai, H; Morita, M; Moriuchi, M; Nakano, Y; Piruzyan, M; Shuto, T; Suico, MA; Takada, M; Tsurekawa, Y | 1 |
| Chen, L; Gao, L; Huang, J; Pang, X; Sun, Y; Wang, H; Wang, J; Wang, T; Zhang, K | 1 |
| Huang, J; Lin, X; Songyang, Z; Wang, M; Zhang, S; Zhao, X; Zheng, G | 1 |
| Chen, C; Duan, Q; Jia, J; Jing, H; Li, C; Li, F; Liu, J; Shao, Y; Wang, N; Wang, Q; Wang, X; Xiao, L; Yang, P; Zheng, Y | 1 |
| Bian, J; Fan, T; Geng, W; Liao, L; Liu, R; Ruan, Q; Shi, W; Wang, S; Wang, T | 1 |
| Gao, M; Si, X | 1 |
| Han, L; Hou, S; Shan, S; Wang, H; Xu, R; Zhu, C | 1 |
| Adame, S; Adhami, VM; Babatunde, AS; Bharali, DJ; Chamcheu, JC; Esnault, S; Longley, BJ; Massey, RJ; Mousa, SA; Mukhtar, H; Siddiqui, IA; Wood, GS | 1 |
| Dainichi, T; Egawa, G; Hayden, MS; Honda, T; Ishii, KJ; Kabashima, K; Kitoh, A; Kobayashi, T; Matsumoto, R; Nakajima, S; Nakano, Y; Nomura, T; Otsuka, A; Sakurai, K; Sugimoto, Y; Tanaka, M; Tsuchiya, S | 1 |
| Cao, H; Chen, L; Li, X; Shen, X; Shi, R; Wang, D; Xia, Q; Xu, H; Xue, F; Yang, H; Yuan, W; Zhao, X; Zheng, J | 1 |
| Hsu, PY; Su, CC; Yang, TH; Yen, HH | 1 |
| Chen, G; Liao, Y; Liu, Y; Lu, Q; Shen, W; Su, Y; Wu, R; Zhang, J; Zhao, M; Zheng, M | 1 |
| Kang, NW; Kim, DD; Kim, KT; Kim, MH; Lee, JY; Lee, SY; Park, JH; Sohn, SY | 1 |
| Alalaiwe, A; Chen, HH; Fang, JY; Hu, KY; Hung, CF; Leu, YL; Tahara, K | 1 |
| Bryszewska, M; Ionov, M; Jain, A; Khan, W; Kommineni, N; Pandi, P | 1 |
| Asano, Y; Hau, CS; Kadono, T; Kamata, M; Mitsui, A; Sato, S; Shibata, S; Shimizu, T; Sugaya, M; Tada, Y; Takeoka, S; Watanabe, S | 1 |
| Ahn, SH; Nguyen, LTH; Nguyen, UT; Yang, IJ | 1 |
| Anderson, LS; Han, D; Hwang, ST; Imai, Y; Simon, SI; Wu, X; Yu, S; Zhou, Y | 1 |
| Chen, W; Jia, X; Kuang, Y; Liao, L; Lu, Y; Qin, Q; Wu, L; Zhang, H; Zhu, W | 1 |
| Miura, T; Yamamoto, T | 1 |
| Arkless, KL; Aubdool, AA; Brain, SD; Caton, P; Cleary, SJ; Evans, E; Kee, Z; Kodji, X; Pitchford, SC | 1 |
| Hsu, PY; Su, CC; Yang, HJ; Yang, TH | 1 |
| Chen, HX; Dong, CZ; Du, ZY; Fang, YX; Li, PH; Li, YL; Liu, GR; Tang, YD; Yan, L; Zhang, K; Zhou, W | 1 |
| Chen, Y; Dai, Z; Han, L; Liang, CL; Liu, H; Lu, C; Qiu, F; Zhang, Q | 1 |
| Davis, R; Griffith, AD; Hadiono, M; Pietro, A; Popkin, DL; Yang, JS; Zaidi, AK | 1 |
| Li, RH; Qiao, M; Sun, Q; Wang, XY; Yan, JJ; Zhao, XT | 1 |
| Cun, D; Lin, Z; Liu, Z; Sun, L; Tong, HH; Wang, R; Yan, R; Zheng, Y | 1 |
| Haba, R; Kubota, Y; Kushida, Y; Nakai, K | 1 |
| Auepemkiate, S; Chorachoo, J; Furnholm, T; Johnston, A; Lambert, S; Reingold, L; Roberts, L; Voravuthikunchai, SP | 1 |
| Bezdek, S; Bucala, R; Busch, H; Dahlke, M; Leng, L; Mousavi, S; Rades, D; Sadik, CD; Zillikens, D | 1 |
| Harada, K; Iwakura, Y; Nakae, S; Numata, T; Shimura, E; Sudo, K; Tsuboi, R; Yamaguchi, S; Yoshizaki, T | 1 |
| Brand, A; Clausen, BE; Daiber, A; Karbach, S; Klebow, S; Kolbinger, F; Kossmann, S; Münzel, T; Roohani, S; Schüler, R; Ullmann, E; Veras, FP; Waisman, A; Wenzel, P; Wild, J; Wohn, C | 1 |
| Li, D; Liu, H; Liu, Z; Opoku, YK; Ren, G; Song, L; Sun, X; Wang, X; Wang, Y; Xu, P; Yang, J; Yin, Q; Yu, D; Zhang, T | 1 |
| Albanesi, C; Cavani, A; Dinarello, CA; Doti, N; Eisenmesser, EZ; Gubinelli, E; Madonna, S; Mazzanti, C; Mercurio, L; Morelli, M; Pagnanelli, G; Ruvo, M; Scarponi, C | 1 |
| Bezdek, S; Guillen, N; Meshrkey, F; Mócsai, A; Mousavi, S; Nimmerjahn, F; Sadik, CD; Seeling, M; Sezin, T; Thieme, M; Wannick, M; Zillikens, D | 1 |
| Akiyama, T; Hashimoto, T; Sakai, K; Sanders, KM; Yosipovitch, G | 1 |
| Deng, Y; Dong, Y; Huang, X; Liu, M; Liu, Q; Wu, T; Yu, P; Zhang, J | 1 |
| Hara, Y; Kawada, A; Kitahata, K; Matsuo, K; Naganuma, T; Nakayama, T; Oiso, N | 1 |
| Aoki, R; Arai, MM; Harada, Y; Hisamatsu, T; Kanai, T; Kiyohara, H; Koda, Y; Mikami, Y; Miyamoto, K; Mizuno, S; Naganuma, M; Nomura, E; Sujino, T; Teratani, T | 1 |
| Carstens, E; Carstens, M; Domocos, DT; Follansbee, T; Han, D; Hwang, ST; Shi, Z; Wu, X; Yu, S; Zhou, Y | 1 |
| Jeon, SH; Kim, CH; Koo, DB; Lee, JH; Lim, CY; Park, MY; Yoo, JK | 1 |
| Chen, M; Li, Y; Tang, F; Tong, M; Wen, H; Xiao, R; Zhang, G; Zhao, M | 1 |
| Akiyama, T; Sakai, K | 1 |
| Han, D; Hwang, ST; Jena, PK; Sheng, L; Wan, YJY; Wu, X; Yu, S; Zhou, Y | 1 |
| Pruthi, V; Raghuwanshi, N; Raj, U; Srivastava, AK; Varadwaj, P; Yadav, TC | 1 |
| Becher, B; Cheng, P; Conrad, C; Dummer, R; Flatz, L; Hartwig, T; Navarini, A; Schlapbach, C; Schreiner, B; Yawalkar, N; Zwicky, P | 1 |
| Bai, J; Cai, W; Chen, L; Gao, Y; Li, Q; Lou, F; Lu, S; Niu, L; Sun, Y; Wang, H; Wang, Z; Wei, Z; Xu, Z; Yin, Q; Zhang, J; Zhou, A; Zhou, H | 1 |
| Farber, JM; Hwang, ST; Singh, TP; Zhang, HH | 1 |
| Fujimori, Y; Hamada, A; Imai, Y; Yamahara, K; Yamanishi, K | 1 |
| Dang, E; Fang, H; Guo, W; Jiang, M; Ke, Y; Qiao, H; Qiao, P; Shen, S; Wang, G; Zhang, J; Zhuang, Y | 1 |
| Aihara, M; Asami, M; Komitsu, N; Takamura, N; Watanabe, Y; Yamaguchi, Y | 1 |
| Di, T; Li, N; Li, P; Li, X; Liu, Z; Meng, Y; Wang, M; Xie, X; Zhai, C; Zhang, L | 1 |
| Chen, H; Duan, J; Duan, X; Gan, L; Liu, D; Liu, X; Lu, X; Poorun, D; Zhang, S | 1 |
| Kurschus, FC; Mohebiany, AN; Moos, S; Waisman, A | 1 |
| Cao, J; Chen, J; Chen, X; Fu, Y; Guo, L; Hu, J; Li, P; Li, W; Li, Y; Liu, L; Peng, J; Qiu, C; Qu, R; Vasilev, K; Wang, W; Zhao, Y; Zhou, G | 1 |
| Chen, HD; Gao, XH; Gao, YL; Han, Y; Huang, Y; Niu, XL; Qi, RQ; Sun, YZ | 1 |
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| Khan, W; Kommineni, N; Raza, K; Saka, R; Sathe, P | 1 |
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| Cho, KA; Hahn, S; Kim, YH; Lee, Y; Park, JW; Park, WJ; Ryu, KH; Shin, SH; Woo, SY | 1 |
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| Lin, Z; Liu, Z; Meng, S; Sun, L; Wang, L; Wang, Z; Xi, L; Zheng, Y | 1 |
| Kuang, H; Li, T; Sun, Y; Wang, Q; Wei, Z | 1 |
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| Fukaya, S; Fukuyasu, A; Hayashi, K; Ishikawa, T; Kamata, M; Ohnishi, T; Shimizu, T; Tada, Y; Tanaka, T | 1 |
| Honda, K; Lee, HC; Ohba, M; Okuno, T; Takahashi, N; Takamori, K; Tominaga, M; Yasukawa, K; Yokomizo, T | 1 |
| Iversen, L; Johansen, C; Ommen, P; Weimar, I | 1 |
| Chen, X; Fang, F; Yi, F; Zhang, J; Zheng, X; Zhou, B | 1 |
| Hooper, KM; Jensen, LE; Lian, LH; Milora, KA; Uribe-Herranz, M | 1 |
| Asano, Y; Hau, CS; Kamata, M; Kanda, N; Noda, S; Sato, S; Shibata, S; Tada, Y; Tatsuta, A; Watanabe, S | 1 |
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| Hu, J; Li, H; Wen, C; Yang, R; Zhao, H; Zhao, M; Zhou, Q | 1 |
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| Hu, J; Sun, J; Zhao, Y | 1 |
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| Hu, J; Li, H; Wen, C; Yang, R; Zhao, H | 1 |
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| Hau, CS; Kanda, N; Sato, S; Shibata, S; Tada, Y; Watanabe, S | 1 |
| Honda, T; Kabashima, K; Malissen, B; Nakamizo, S; Nakamura, M; Ohmori, S; Sawada, Y; Sugita, K; Tokura, Y; Yoshiki, R; Yoshioka, H | 1 |
| Choi, EJ; Hong, MP; Kie, JH; Kim, HR; Lee, A; Lee, HK; Lim, W; Moon, BI; Seoh, JY | 1 |
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| Bai, XC; Chen, TY; Feng, JY; Li, YM; Ma, J; Qin, S; Wen, J; Zheng, RC; Zhong, BL; Zhou, GB | 1 |
| Alvarez, D; Naval, E; Ordovas-Montanes, J; Paust, S; Perro, M; Riol-Blanco, L; Thiriot, A; von Andrian, UH; Wood, JN | 1 |
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| Sadik, CD; Sezin, T; Zillikens, D | 1 |
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| Clausen, BE; Ober-Blöbaum, JL; Pantelyushin, S; Wohn, CT | 1 |
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| Boakye, CH; Godugu, C; Mendonca Faria, HA; Patel, AR; Singh, M; Somagoni, J; Zucolotto, V | 1 |
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| Borkner, L; Frenzel, DF; Scharffetter-Kochanek, K; Scheurmann, J; Singh, K; Weiss, JM | 1 |
| Hjuler, KF; Iversen, L; Johansen, C; Khatib, SH; Kjellerup, RB; Langkilde, A; Raaby, L; Vinter, H | 1 |
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| Fan, H; Harris, J; Jones, SA; Morand, EF; Perera, DN; Russ, BE | 1 |
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| Aihara, M; Komitsu, N; Watanabe, T; Watanabe, Y; Yamaguchi, Y | 1 |
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| Asano, Y; Hau, CS; Kadono, T; Kadowaki, T; Kamata, M; Kubota, N; Kurokawa, M; Masamoto, Y; Mitsui, A; Sato, S; Shibata, S; Sugaya, M; Tada, Y; Yamauchi, T | 1 |
| Di, T; Li, P; Lin, Y; Liu, X; Wang, Y; Zeng, Z; Zhang, L; Zhao, J | 1 |
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| Bertelsen, T; Hailfinger, S; Iversen, L; Johansen, C; Lorscheid, S; Mose, M; Ommen, P; Schulze-Osthoff, K; Vinter, H | 1 |
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| Gaestel, M; Iversen, L; Johansen, C; Kragballe, K; Steiniche, T; Vinter, H | 1 |
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| Ballegeer, M; Grine, L; Libert, C; Lienenklaus, S; Sanders, NN; Steeland, S; Van Ryckeghem, S; Vandenbroucke, RE; Weiss, S | 1 |
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| Adhami, VM; Chamcheu, JC; Chaves-Rodriquez, MI; Longley, BJ; Mukhtar, H; Siddiqui, IA; Wood, GS | 1 |
| Bao, YL; Huang, YX; Li, WL; Li, YX; Song, ZB; Sun, LG; Wang, Q; Yang, XG; Yu, CL; Zhang, WJ | 1 |
| Grine, L; Libert, C; Vandenbroucke, RE | 1 |
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| Chao, YH; Chen, DY; Chen, HH; Chung, TW; Li, YR; Lin, CC; Yang, DH | 1 |
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| Chang, KT; Choo, YK; Kim, CH; Kim, JS; Kim, SU; Lee, JM; Yoo, JK | 1 |
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| Iversen, L; Johansen, C; Vinter, H | 1 |
| Amiaud, J; Atanassov, H; Bernard, FX; Blanchard, F; Favot, L; Guesdon, W; Jégou, JF; Lecron, JC; Mcheik, J; Mekouo, AA; Morel, F; Paris, I; Pohin, M; Rabeony, H; Richards, CD | 1 |
| Dainichi, T; Hirakawa, S; Honda, T; Kabashima, K; Kitoh, A; Miyachi, Y; Nakajima, S; Nakashima, C; Nonomura, Y; Otsuka, A; Wong, LS; Yamamoto, Y | 1 |
| Bugara, B; Celada, A; Ferran, M; Florencia, EF; Giménez-Arnau, A; Jura, J; Lipert, B; Prens, EP; Pujol, RM; Ruiz-Romeu, E; Santamaria-Babí, LF | 1 |
| Liu, JH; Luo, DQ; Wang, F; Wu, HH; Zhao, YK | 1 |
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| Shao, F; Sun, Y; Tan, T; Tan, Y; Wu, X; Xu, Q | 1 |
| Bezdek, S; Hdnah, A; Ibrahim, S; Ludwig, RJ; Mousavi, S; Sadik, CD; Sezin, T; Zillikens, D | 1 |
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| Cao, N; Chen, T; Fu, LX; Lu, YH; Yin, B; Zhang, LW; Zhou, PM | 1 |
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| Benito, C; Casas, E; Ciruela, F; de Anta, JM; Díez-Villanueva, A; Ferran, M; Gómez, D; López-Cano, M; Manils, J; Marruecos, L; Perrino, FW; Soler, C; Vavouri, T; Viña-Vilaseca, A | 1 |
| Chong, HT; Cowin, AJ; Ibbetson, J; Kopecki, Z; Sidhu, S; Yang, GN | 1 |
| Amberg, N; Holcmann, M; Sibilia, M; Stulnig, G | 1 |
| Adhami, VM; Chamcheu, JC; Chaves-Rodriquez, MI; Dodwad, SM; Esnault, S; Longley, BJ; Mukhtar, H; Satyshur, KA; Sechi, M; Siddiqui, IA; Syed, DN; Wood, GS | 1 |
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| Chen, YJ; Cheng, HY; Ho, LW; Huang, SW; Kao, JK; Narita, M; Shieh, JJ; Takahashi, M; Wang, ST; Wu, CY | 1 |
| Li, R; Ma, H; Wang, J; Wang, M; Wang, X; Xiao, S; Zhou, J | 1 |
| Iversen, L; Johansen, C; Langkilde, A; Ommen, P; Rosada, C; Stenderup, K; Stjernholm, T | 1 |
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| Cho, KA; Kim, JY; Lee, KH; Park, M; Woo, SY | 1 |
| Ballegeer, M; Bruscoli, S; Carceller, E; Deckers, J; Hochepied, T; Libert, C; Pérez, P; Riccardi, C | 1 |
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| Gudjonsson, JE; Hawkes, JE; Ward, NL | 1 |
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| Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Alotaibi, MR; AlSaad, AM; Ansari, MA; Nadeem, A | 1 |
| Diaconu, D; Fritz, Y; Gudjonsson, JE; Liang, Y; Michaels, KA; Sarkar, MK; Sutter, AJ; Swindell, WR; Tsoi, A; Ward, NL; Xing, X | 1 |
| Boon, L; Cornelissen, F; Florencia, E; Kant, M; Laman, JD; Lubberts, E; Mourits, S; Mus, AM; Prens, EP; van der Fits, L; Voerman, JS | 1 |
| Ben Salem, C; Bouraoui, K; Hmouda, H | 1 |
| Cordoro, KM; Greer, KE; Lonergan, CL; McNamara, EK | 1 |
| Levine, VJ; Machler, BC; Mark, NM; Patel, U | 1 |
| Carbajal, S; DiGiovanni, J; Elder, JT; Gudjonsson, JE; Han, G; Johnston, A; Lu, J; Nair, RP; Pittelkow, MR; Prens, EP; Sano, S; Swindell, WR; Voorhees, JJ; Wang, XJ; Ward, NL; Wohn, C; Xing, X | 1 |
| Aguayo, R; Baradad, M; Casanova, JM; Sanmartín, V | 1 |
| Akimoto, T; Ishizaki, M; Maeda, H; Matsuda, T; Muromoto, R; Ohshiro, Y; Oritani, K; Sekine, Y; Shimoda, K; Yokoyama, M | 1 |
| Cheung, PH; Foreman, O; Hain, HS; Kaur, P; Kavirayani, A; Saha, S; Tung, D | 1 |
| Desai, PR; Patel, AR; Shah, PP; Singh, MS | 1 |
| de Heusch, M; Dumoutier, L; Dunussi-Joannopoulos, K; Fouser, LA; Hendrickx, E; Lemaire, MM; Renauld, JC; Van Belle, AB; Warnier, G | 1 |
| Becher, B; Haak, S; Heppner, FL; Ingold, B; Kulig, P; Navarini, AA; Pantelyushin, S | 1 |
| Baek, JO; Byamba, D; Kim, TG; Lee, MG; Wu, WH | 1 |
| El Malki, K; Huppert, J; Karbach, SH; Karram, K; Kuhlmann, CR; Kurschus, FC; Luhmann, HJ; Münzel, T; Nikolaev, A; Reissig, S; Schüler, R; von Stebut, E; Waisman, A; Wörtge, S; Zayoud, M | 1 |
| Asano, Y; Kadono, T; Kanda, N; Sato, S; Shibata, S; Sugaya, M; Tada, Y; Watanabe, S; Yanaba, K | 1 |
| Asselbergh, B; De Rycke, R; Declercq, W; Deforce, D; Denecker, G; Gilbert, B; Hachem, JP; Hoste, E; Prens, EP; van der Fits, L; Van Nieuwerburgh, F; Vandenabeele, P | 1 |
| Dapavo, P; Hirsch, E; Ji, H; Okkenhaug, K; Perino, A; Roller, A; Soro, E | 1 |
| Siller, G; Strutton, G; Wu, JK | 1 |
| Burg, G; Conrad, C; Cozzio, A; Dummer, R; Geiges, M; Gilliet, M; Nestle, FO; Thürlimann, W | 1 |
| Sauder, DN | 1 |
| Langtry, JA; Rajan, N | 1 |
| Dika, E; Fanti, PA; Miscial, C; Vaccari, S; Varotti, C | 1 |
10 review(s) available for imiquimod and Psoriasis
| Article | Year |
|---|---|
Methodological shortcomings in the reports of the imiquimod psoriatic model.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Mice; Psoriasis; Skin | 2022 |
Mouse Models of Psoriasis: A Comprehensive Review.
Topics: Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Mice; Psoriasis; Skin | 2022 |
Great green tea ingredient? A narrative literature review on epigallocatechin gallate and its biophysical properties for topical use in dermatology.
Topics: Administration, Topical; Antioxidants; Biophysical Phenomena; Catechin; Cosmetics; Dermatology; Humans; Imiquimod; Plant Extracts; Psoriasis; Tea | 2020 |
Mesenchymal stem cells for the treatment of psoriasis: a comprehensive review.
Topics: Adjuvants, Immunologic; Adult; Animals; Cell Proliferation; Clinical Trials as Topic; Cytokines; Female; Fetal Blood; Humans; Imiquimod; Immunomodulation; Infusions, Intravenous; Keratinocytes; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Middle Aged; Models, Animal; Psoriasis; T-Lymphocytes; Treatment Outcome | 2020 |
Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Cytokines; Dermatitis; Endosomes; Humans; Imiquimod; Indazoles; Isonicotinic Acids; Mice; Psoriasis; Resveratrol; Signal Transduction; Skin; Stilbenes; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptor 9; Toll-Like Receptors | 2017 |
[Mechanism of psoriasis generation in animal models].
Topics: Aminoquinolines; Amphiregulin; Animals; Disease Models, Animal; EGF Family of Proteins; Humans; Imiquimod; Keratin-14; Keratin-5; Keratinocytes; Membrane Glycoproteins; Mice, Transgenic; Psoriasis; Receptor, TIE-2; STAT3 Transcription Factor; Toll-Like Receptor 7; Transforming Growth Factor beta1 | 2013 |
Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Autoimmunity; Cytosol; DNA, Viral; Endosomes; Humans; Imiquimod; Immunity, Innate; Inflammation; Lupus Erythematosus, Systemic; Nucleic Acids; Psoriasis; Signal Transduction; Toll-Like Receptors; Virus Diseases | 2016 |
Therapeutic targeting of Toll-like receptors: a review of Toll-like receptors and their signaling pathways in psoriasis.
Topics: Aminoquinolines; Animals; Cytokines; Dendritic Cells; Humans; Imiquimod; Keratinocytes; Molecular Targeted Therapy; Psoriasis; Signal Transduction; Toll-Like Receptors | 2016 |
Imiquimod 5% cream induced psoriasis: a case report, summary of the literature and mechanism.
Topics: Adjuvants, Immunologic; Aged; Aminoquinolines; Anti-Inflammatory Agents; Biopsy; Clobetasol; Humans; Imiquimod; Keratosis, Actinic; Male; Psoriasis; Treatment Outcome; Ultraviolet Therapy | 2011 |
Mechanism of action and emerging role of immune response modifier therapy in dermatologic conditions.
Topics: Adjuvants, Immunologic; Alefacept; Aminoquinolines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Calcineurin Inhibitors; CD11 Antigens; Dermatitis, Atopic; Glucocorticoids; Humans; Imiquimod; Interferons; Membrane Glycoproteins; Mycophenolic Acid; Psoriasis; Receptors, Cell Surface; Recombinant Fusion Proteins; Skin Diseases; Tacrolimus; Toll-Like Receptors | 2004 |
1 trial(s) available for imiquimod and Psoriasis
| Article | Year |
|---|---|
Does imiquimod pretreatment optimize 308-nm excimer laser (UVB) therapy in psoriasis patients?
Topics: Administration, Topical; Adult; Aged; Aminoquinolines; Female; Humans; Imiquimod; Laser Therapy; Male; Middle Aged; Psoriasis | 2017 |
698 other study(ies) available for imiquimod and Psoriasis
| Article | Year |
|---|---|
The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation.
Topics: Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Skin | 2021 |
Resveratrol-Loaded Vesicular Elastic Nanocarriers Gel in Imiquimod-Induced Psoriasis Treatment: In Vitro and In Vivo Evaluation.
Topics: Animals; Drug Liberation; Imiquimod; Mice; Psoriasis; Resveratrol; Skin Absorption | 2022 |
Deciphering the mechanism of Fang-Ji-Di-Huang-Decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23/Th17 cell axis.
Topics: Animals; Copper; Drugs, Chinese Herbal; Gene Expression Regulation; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Mice; Phytotherapy; Psoriasis; Th17 Cells | 2021 |
Differential role of TNFR1 and TNFR2 in the development of imiquimod-induced mouse psoriasis.
Topics: Animals; Disease Models, Animal; Female; Imiquimod; Interferon Inducers; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; T-Lymphocytes, Regulatory | 2021 |
Positive Allosteric Modulation of A
Topics: Adenosine; Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Immunity; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2022 |
Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF-κB and VEGFR2 signaling.
Topics: Animals; Apoptosis; Cell Proliferation; Cytokines; HaCaT Cells; Humans; Imiquimod; Indoles; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Neovascularization, Physiologic; NF-kappa B; Psoriasis; Signal Transduction; Skin; Vascular Endothelial Growth Factor Receptor-2 | 2021 |
Apremilast downregulates interleukin-17 production and induces splenic regulatory B cells and regulatory T cells in imiquimod-induced psoriasiform dermatitis.
Topics: Animals; B-Lymphocytes, Regulatory; Disease Models, Animal; Down-Regulation; Female; Humans; Imiquimod; Interleukin-17; Mice; Psoriasis; Spleen; T-Lymphocytes, Regulatory; Thalidomide | 2021 |
Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
Topics: Animals; Cell Proliferation; Humans; Hydrolases; Imiquimod; Inflammation; Keratinocytes; Mice; MicroRNAs; Psoriasis; Skin | 2022 |
Cutaneous Liver X Receptor Activation Prevents the Formation of Imiquimod-Induced Psoriatic Dermatitis.
Topics: Administration, Cutaneous; Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Liver X Receptors; Psoriasis; Skin | 2022 |
Topical Application of Vitamin D
Topics: Animals; Cholecalciferol; Imiquimod; Mice; Nanoparticles; Particle Size; Psoriasis | 2021 |
Integrated Metabolomics and Transcriptomics Analyses Reveal Histidine Metabolism Plays an Important Role in Imiquimod-Induced Psoriasis-like Skin Inflammation.
Topics: Animals; Female; Histidine; Imiquimod; Metabolome; Mice; Mice, Inbred C57BL; Psoriasis; Transcriptome | 2021 |
Losartan ointment attenuates imiquimod-induced psoriasis-like inflammation.
Topics: Administration, Cutaneous; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Imiquimod; Interleukin-17; Losartan; Male; Mice; Ointments; Psoriasis; Receptor, Angiotensin, Type 1; Skin; Th17 Cells | 2021 |
IL-30 ameliorates imiquimod and K14-VEGF induced psoriasis-like disease by inhibiting both innate and adaptive immunity disorders.
Topics: Adaptive Immunity; Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Cytokines; Humans; Imiquimod; Inflammation; Interleukins; Keratin-14; Keratinocytes; Lymphocytes; Mice; Psoriasis; Signal Transduction; Vascular Endothelial Growth Factor A | 2021 |
First-in-class topical therapeutic omilancor ameliorates disease severity and inflammation through activation of LANCL2 pathway in psoriasis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Disease Susceptibility; Imiquimod; Immunosuppressive Agents; Inflammation Mediators; Keratinocytes; Membrane Proteins; Mice; Mice, Knockout; Phosphate-Binding Proteins; Psoriasis; Signal Transduction; T-Lymphocyte Subsets | 2021 |
Alkyl-Terminated Gold Nanoparticles as a Self-Therapeutic Treatment for Psoriasis.
Topics: Animals; Disease Models, Animal; Gold; Imiquimod; Keratinocytes; Metal Nanoparticles; Mice; Nanoparticles; Psoriasis | 2021 |
Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages.
Topics: Animals; Female; Humans; Imiquimod; Inflammation; Macrophages; Mice; Mice, Inbred BALB C; Mitochondrial Dynamics; Mitochondrial Proteins; Psoriasis; THP-1 Cells | 2021 |
Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway.
Topics: Animals; Apoptosis; Biomarkers; Cell Cycle; Cell Proliferation; Cells, Cultured; Gene Expression Regulation; Humans; Imiquimod; Interferon Inducers; Keratinocytes; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Receptors, Lysophosphatidic Acid; rho-Associated Kinases | 2021 |
Cudraxanthone D Ameliorates Psoriasis-like Skin Inflammation in an Imiquimod-Induced Mouse Model via Inhibiting the Inflammatory Signaling Pathways.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Female; Humans; Imiquimod; Interferon-gamma; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Moraceae; NF-kappa B; Plant Extracts; Plant Roots; Psoriasis; Treatment Outcome; Tumor Necrosis Factor-alpha; Xanthones | 2021 |
Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Imiquimod; Inflammation; Interferon-gamma; Keratinocytes; Lignans; Mice, Inbred C57BL; NF-kappa B; Psoriasis; Signal Transduction; STAT1 Transcription Factor; Th1 Cells; Th17 Cells; Tumor Necrosis Factor-alpha | 2021 |
MiR-193b-3p-ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes.
Topics: Animals; Antagomirs; Base Sequence; Cell Proliferation; Disease Models, Animal; Down-Regulation; Female; HaCaT Cells; Humans; Imiquimod; Inflammation; Inflammation Mediators; Keratinocytes; Male; Mice, Inbred C57BL; MicroRNAs; Models, Biological; Psoriasis; Receptor, ErbB-4; RNA, Messenger; Skin | 2021 |
PI3Kδ Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis.
Topics: Administration, Topical; Animals; Apoptosis; Biomarkers; Cell Differentiation; Cell Movement; Cell Proliferation; Cytokines; Epithelium; Female; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Keratinocytes; Mice, Inbred BALB C; Models, Biological; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Psoriasis; Pyridines; Quinolines; Signal Transduction; Skin; Up-Regulation | 2021 |
Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis.
Topics: Adipocytes; Adipokines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Keratinocytes; Lysosomal Membrane Proteins; Mice; Psoriasis; STAT3 Transcription Factor | 2022 |
Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Curcumin; Cytokines; Disease Models, Animal; Imiquimod; Interleukin-12 Subunit p40; Interleukin-17; Psoriasis; Rats; Skin; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Ustekinumab | 2022 |
NF-κB1 Contributes to Imiquimod-Induced Psoriasis-Like Skin Inflammation by Inducing Vγ4
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2022 |
Lymphatic Dysfunction Exacerbates Cutaneous Tumorigenesis and Psoriasis-Like Skin Inflammation through Accumulation of Inflammatory Cytokines.
Topics: Animals; Carcinogenesis; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Lymphatic System; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2022 |
TMT-based proteomics analysis reveals the protective effect of Jueyin granules on imiquimod-induced psoriasis mouse model by causing autophagy.
Topics: Animals; Autophagy; Disease Models, Animal; Humans; Imiquimod; Mice; Neoplasm Recurrence, Local; Proteomics; Psoriasis | 2022 |
Use of Cytokine Mix-, Imiquimod-, and Serum-Induced Monoculture and Lipopolysaccharide- and Interferon Gamma-Treated Co-Culture to Establish In Vitro Psoriasis-like Inflammation Models.
Topics: Adult; Cells, Cultured; Coculture Techniques; Cytokines; Gene Expression Profiling; Gene Expression Regulation; Genetic Markers; HaCaT Cells; Humans; Imiquimod; Inflammation; Interferon-gamma; Keratinocytes; Lipopolysaccharides; Models, Biological; Psoriasis; RNA, Messenger; Serum; Tetradecanoylphorbol Acetate | 2021 |
Total withanolides ameliorates imiquimod-induced psoriasis-like skin inflammation.
Topics: Animals; Computational Biology; Gene Expression Regulation; Imiquimod; Inflammation; Interferon Inducers; Male; Mice; Mice, Inbred BALB C; Protein Interaction Maps; Psoriasis; Random Allocation; Signal Transduction; Up-Regulation; Withanolides; Zonula Occludens-1 Protein | 2022 |
Salubrinal protects against inflammatory response in macrophage and attenuates psoriasiform skin inflammation by antagonizing NF-κB signaling pathway.
Topics: Animals; Cinnamates; Disease Models, Animal; Imiquimod; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Protective Agents; Psoriasis; RAW 264.7 Cells; Signal Transduction; Skin; Thiourea; Tumor Necrosis Factor-alpha | 2022 |
A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency.
Topics: Administration, Topical; Animals; Anthraquinones; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Emodin; HaCaT Cells; Humans; Imiquimod; Inflammation; Keratinocytes; Macrophages; Mice; Psoriasis; Rheum; Skin Absorption; Swine | 2022 |
Terrestrosin D ameliorates skin lesions in an imiquimod-induced psoriasis-like murine model by inhibiting the interaction between Substance P and Dendritic cells.
Topics: Animals; Cell Proliferation; Cytokines; Dendritic Cells; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Saponins; Skin; Substance P | 2022 |
Decreased microRNA-126 expression in psoriatic CD4
Topics: Animals; Cell Differentiation; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; MicroRNAs; Psoriasis; Skin; Th17 Cells | 2022 |
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis.
Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Mice; Psoriasis; Skin; Toll-Like Receptor 7 | 2022 |
Protective effect of Yangxue Jiedu Soup against psoriasis-like lesions by regulating TLR4/NF-κB signaling pathway mediated by secretion of exosome HSP70.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drugs, Chinese Herbal; HSP70 Heat-Shock Proteins; Imiquimod; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Phytotherapy; Psoriasis; Signal Transduction; Toll-Like Receptor 4 | 2022 |
Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis.
Topics: Animals; Cytokines; Dendritic Cells; Disease Models, Animal; Flavonols; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2022 |
[Effect of moxibustion on skin lesions and immune inflammatory response in psoriasis mice].
Topics: Animals; Imiquimod; Male; Mice; Moxibustion; Psoriasis; Skin; Spleen; Tumor Necrosis Factor-alpha | 2022 |
Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling‒Mediated Sensory Neuron‒Dendritic Cell Communication.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Communication; Dendritic Cells; Imiquimod; Interleukin-23; Lidocaine; Pilot Projects; Psoriasis; Rats; Sensory Receptor Cells | 2022 |
Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells.
Topics: Animals; Disease Models, Animal; Female; Gels; Imiquimod; Interleukin-23; Langerhans Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pentacyclic Triterpenes; Psoriasis; Tripterygium | 2022 |
SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model.
Topics: Animals; Dendritic Cells; Humans; Imiquimod; Mice; Nucleic Acids; Psoriasis; Toll-Like Receptor 7; Toll-Like Receptor 9 | 2022 |
Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice.
Topics: Animals; Disease Models, Animal; Eczema; Imiquimod; Inflammation; Mice; Psoriasis; Skin | 2022 |
TNFR2 Depletion Reduces Psoriatic Inflammation in Mice by Downregulating Specific Dendritic Cell Populations in Lymph Nodes and Inhibiting IL-23/IL-17 Pathways.
Topics: Animals; Dendritic Cells; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Lymph Nodes; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2022 |
LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2‒NLRC4 Axis.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Keratinocytes; Lipocalin-2; Mice; Psoriasis; Skin; Sterol Regulatory Element Binding Protein 2 | 2022 |
Design and synthesis of the 4H-chromenone derivatives against psoriasis.
Topics: Animals; Disease Models, Animal; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Tumor Necrosis Factor-alpha | 2022 |
Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model.
Topics: Animals; Disease Models, Animal; Imiquimod; Mice; Psoriasis; Receptors, Aryl Hydrocarbon; Skin; Th17 Cells | 2022 |
Transcutaneous delivery of mung bean-derived nanoparticles for amelioration of psoriasis-like skin inflammation.
Topics: Animals; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; Skin; Vigna | 2022 |
Activation of the STING-IRF3 pathway involved in psoriasis with diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Imiquimod; Interferon Regulatory Factor-3; Mice; Psoriasis | 2022 |
Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice.
Topics: Animals; Anxiety; Behavior, Animal; Berberine; Imiquimod; Male; Mice; Mice, Inbred BALB C; Psoriasis | 2022 |
KdPT alleviates imiquimod-induced psoriasis-like skin lesion in mice via inhibiting proliferation and inflammation response.
Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Cytokines; Disease Models, Animal; Endothelial Cells; Imiquimod; Inflammation; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Tumor Necrosis Factor-alpha | 2022 |
Selenium-Rich Yeast Peptide Fraction Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Inhibiting Inflammation via MAPK and NF-κB Signaling Pathways.
Topics: Animals; Cell Line; Dermatitis; Disease Models, Animal; Female; Humans; Hydrogen Peroxide; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Peptides; Psoriasis; RAW 264.7 Cells; Selenium; Signal Transduction; Skin; Yeasts | 2022 |
Ginsenoside Rg1 ameliorates psoriasis-like skin lesions by suppressing proliferation and NLRP3 inflammasomes in keratinocytes.
Topics: Animals; Cell Proliferation; Ginsenosides; Humans; Imiquimod; Inflammasomes; Keratinocytes; Ki-67 Antigen; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Quality of Life; Reactive Oxygen Species; Sincalide | 2022 |
The effectiveness of synthetic methoxylated isoflavones in delivering to the skin and alleviating psoriasiform lesions via topical absorption.
Topics: Animals; Disease Models, Animal; Imiquimod; Isoflavones; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Swine | 2022 |
Secretory leukocyte protease inhibitor regulates nerve reflex-mediated skin barrier function in psoriasis.
Topics: Animals; Imiquimod; Mice; Psoriasis; Reflex; Secretory Leukocyte Peptidase Inhibitor; Skin | 2022 |
D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis.
Topics: Animals; Imiquimod; Inflammation; Intraepithelial Lymphocytes; Mannose; Mice; Psoriasis; Skin | 2022 |
IL-17A Promotes Psoriasis-Associated Keratinocyte Proliferation through ACT1-Dependent Activation of YAP-AREG Axis.
Topics: Amphiregulin; Animals; Antibodies, Monoclonal, Humanized; Cell Proliferation; HaCaT Cells; Humans; Imiquimod; Interleukin-17; Keratinocytes; Mice; Psoriasis; Skin | 2022 |
Adiponectin-derived pentapeptide ameliorates psoriasiform skin inflammation by suppressing IL-17 production in γδT cells.
Topics: Adiponectin; Animals; Disease Models, Animal; Eczema; Imiquimod; Inflammation; Interleukin-17; Mice; Psoriasis; Receptors, Adiponectin; Skin | 2022 |
Human umbilical cord-derived mesenchymal stem cells ameliorate psoriasis-like dermatitis by suppressing IL-17-producing γδ T cells.
Topics: Animals; Dermatitis; Humans; Imiquimod; Inflammation; Interleukin-17; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Psoriasis; T-Lymphocytes; Umbilical Cord | 2022 |
Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis.
Topics: Animals; Ceramides; Cholesterol; Disease Models, Animal; Imiquimod; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Surface-Active Agents | 2022 |
Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4
Topics: Animals; Benzylisoquinolines; Forkhead Transcription Factors; Imiquimod; Mice; Psoriasis; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; T-Lymphocytes, Regulatory | 2022 |
Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis.
Topics: Animals; Imiquimod; Lipopolysaccharides; Macrophages; Methotrexate; Mice; Naphthoquinones; Psoriasis | 2022 |
3, 3'- diindolylmethane hinders IL-17A/IL-17RA interaction and mitigates imiquimod-induced psoriasiform in mice.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Indoles; Interleukin-17; Janus Kinases; Keratinocytes; Mice; Psoriasis; Signal Transduction; Skin; STAT Transcription Factors; Vascular Endothelial Growth Factor A | 2022 |
Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61.
Topics: Animals; China; Cysteine-Rich Protein 61; Disease Models, Animal; Drugs, Chinese Herbal; Imiquimod; Inflammation; Intercellular Adhesion Molecule-1; Interferon-gamma; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger | 2022 |
CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Imiquimod; Inflammation; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Nerve Tissue Proteins; NF-kappa B; Psoriasis; Receptors, Nicotinic | 2022 |
[Effect of fire needling on imiquimod induced psoriasis-like lesion and STAT3 pathway in mice].
Topics: Animals; Dexamethasone; Imiquimod; Interleukin-17; Ki-67 Antigen; Male; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger; Skin; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2022 |
Transglutaminase 3 Attenuates Skin Inflammation in Psoriasis by Inhibiting NF-κB Activation through Phosphorylated STAT3-TET3 Signaling.
Topics: Animals; Cysteamine; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; RNA, Small Interfering; Skin; STAT3 Transcription Factor; Transglutaminases | 2022 |
Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.
Topics: Animals; Cytokines; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Acids, Omega-3; Imiquimod; Interleukin-17; Interleukin-23; Mice; Psoriasis; Skin | 2022 |
The Protective Role of pVHL in Imiquimod-Induced Psoriasis-like Skin Inflammation.
Topics: Animals; Dermatitis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imiquimod; Inflammation; Interleukin-17; Mice; Psoriasis; Tumor Necrosis Factor-alpha; Von Hippel-Lindau Tumor Suppressor Protein | 2022 |
The Essential Oil Derived from
Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-1; Interleukin-17; Interleukin-23; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Oils, Volatile; Perilla frutescens; Psoriasis; Skin | 2022 |
Synthesis and In-Vivo Evaluation of Benzoxazole Derivatives as Promising Anti-Psoriatic Drugs for Clinical Use.
Topics: Animals; Benzoxazoles; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred CBA; Pharmaceutical Preparations; Psoriasis; Skin | 2022 |
Psoriasis-like skin lesions occurring at remote sites after topical imiquimod.
Topics: Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases | 2022 |
Lck signaling inhibition causes improvement in clinical features of psoriatic inflammation through reduction in inflammatory cytokines in CD4+ T cells in imiquimod mouse model.
Topics: Adjuvants, Immunologic; Animals; CD4-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Psoriasis; Pyrazoles; Pyrimidines; Skin; Tumor Necrosis Factor-alpha | 2022 |
Epicutaneous Application of Imiquimod to Model Psoriasis-Like Skin Disease Induces Water-Saving Aestivation Motifs and Vascular Inflammation.
Topics: Animals; Disease Models, Animal; Estivation; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases; Water | 2022 |
Notch1/Hes1‑PTEN/AKT/IL‑17A feedback loop regulates Th17 cell differentiation in mouse psoriasis‑like skin inflammation.
Topics: Animals; Cell Differentiation; Dermatitis; Feedback; Imiquimod; Inflammation; Interleukin-17; Lymphadenopathy; Mechanistic Target of Rapamycin Complex 1; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Skin; Splenomegaly; Th17 Cells; Transcription Factor HES-1 | 2022 |
Dietary olive oil intake aggravates psoriatic skin inflammation in mice via Nrf2 activation and polyunsaturated fatty acid imbalance.
Topics: Animals; Dermatitis; Diet; Disease Models, Animal; Fatty Acids, Unsaturated; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Olive Oil; Psoriasis; Skin; Skin Diseases | 2022 |
Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions.
Topics: Animals; Disease Models, Animal; Estradiol; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Macrophages; Mice; Mice, Knockout; Neutrophils; Psoriasis; Receptors, Estrogen; Skin | 2022 |
Nanocrystal-based gel of apremilast ameliorates imiquimod-induced psoriasis by suppressing inflammatory responses.
Topics: Animals; Disease Models, Animal; Gels; Imiquimod; Nanoparticles; Psoriasis; Skin; Thalidomide | 2022 |
Lithosepermic Acid Restored the Skin Barrier Functions in the Imiquimod-Induced Psoriasis-like Animal Model.
Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2022 |
Dimeric translationally controlled tumor protein-binding peptide 2 attenuates imiquimod-induced psoriatic inflammation through induction of regulatory T cells.
Topics: Animals; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Peptides; Psoriasis; Skin; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Protein, Translationally-Controlled 1 | 2022 |
Sprouty1 exerts a preventive effect on the initiation of psoriasis by inhibiting innate immune antimicrobial peptide cathelicidin and immunocytes.
Topics: Animals; Antimicrobial Cationic Peptides; Antimicrobial Peptides; Cathelicidins; Disease Models, Animal; Eosine Yellowish-(YS); Hematoxylin; Humans; Imiquimod; Immunity, Innate; Inflammation; Interleukin-17; Keratinocytes; Membrane Proteins; Mice; Phosphoproteins; Psoriasis; Skin | 2022 |
Tiamulin inhibits TNF-α and alleviates psoriasis-like dermatitis.
Topics: Animals; Dermatitis; Disease Models, Animal; Diterpenes; Imiquimod; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Tumor Necrosis Factor-alpha | 2022 |
An Emerging Role of
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Imiquimod; Interleukin-17; Interleukin-23; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Proanthocyanidins; Psoriasis; Reactive Oxygen Species; RNA, Messenger; Skin; Superoxide Dismutase; Vascular Endothelial Growth Factor A | 2022 |
Anti-IL-17A ssDNA aptamer ameliorated psoriasis skin lesions in the imiquimod-induced psoriasis mouse model.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; DNA, Single-Stranded; Imiquimod; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Psoriasis; RNA, Messenger; Skin | 2022 |
Topical VX-509 attenuates psoriatic inflammation through the STAT3/FABP5 pathway in keratinocytes.
Topics: Animals; Disease Models, Animal; Fatty Acid-Binding Proteins; Heterocyclic Compounds, 2-Ring; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Psoriasis; Skin; STAT3 Transcription Factor; Valine | 2022 |
DPP-4 inhibitor linagliptin ameliorates imiquimod-induced psoriasis-like skin alterations in type 2 diabetic mice by inhibiting the MAPK/NF-κB inflammatory pathway.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Hypoglycemic Agents; Imiquimod; Insulin Resistance; Interleukin-23; Linagliptin; Mice; NF-kappa B; Psoriasis; Tumor Necrosis Factor-alpha | 2022 |
Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17/IL-17 axis by activating PPARγ.
Topics: Animals; Disease Models, Animal; Estrogens; Flavonoids; Imiquimod; Interleukin-17; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; PPAR gamma; Protein Kinases; Psoriasis; Skin; Skin Diseases; Th17 Cells; Tumor Necrosis Factor-alpha; Wnt Signaling Pathway | 2022 |
Dynamic trafficking patterns of IL-17-producing γδ T cells are linked to the recurrence of skin inflammation in psoriasis-like dermatitis.
Topics: Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-17; Mice; Psoriasis; Skin; T-Lymphocytes | 2022 |
Exacerbation of psoriatic arthritis due to topical imiquimod therapy.
Topics: Administration, Topical; Aminoquinolines; Animals; Arthritis, Psoriatic; Disease Models, Animal; Humans; Imiquimod; Psoriasis; Skin | 2023 |
Functional Interplay between IL-9 and Peptide YY Contributes to Chronic Skin Inflammation.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-9; Keratinocytes; Mice; Peptide YY; Psoriasis; Skin | 2022 |
SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction.
Topics: Animals; Calcium; Cell Proliferation; Epidermis; Humans; Imiquimod; Keratinocytes; Mice; Psoriasis; Serpins | 2022 |
Ciclopirox inhibits NLRP3 inflammasome activation via protecting mitochondria and ameliorates imiquimod-induced psoriatic inflammation in mice.
Topics: Animals; Ciclopirox; Imiquimod; Inflammasomes; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Reactive Oxygen Species | 2022 |
Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Disease Models, Animal; Humans; Imiquimod; Inflammation; Keratinocytes; Macrophages; Mice; Psoriasis | 2022 |
Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice.
Topics: Administration, Topical; Animals; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin 1 Receptor Antagonist Protein; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Secretome; Skin | 2022 |
Sinomenine Suppressed Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis by Regulating lncRNA XIST.
Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; RNA, Long Noncoding; Skin Diseases | 2022 |
Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis.
Topics: Amino Acids; Animals; Carnitine; Cimicifuga; Cytokines; Disease Models, Animal; Imiquimod; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Network Pharmacology; Plant Extracts; Psoriasis; RNA-Seq; Skin; Smilax | 2022 |
Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Imiquimod; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Psoriasis | 2022 |
Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models.
Topics: Animals; Cholesterol Ester Transfer Proteins; Disease Models, Animal; Imiquimod; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phospholipid Transfer Proteins; Psoriasis | 2022 |
Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice.
Topics: Animals; Carrier Proteins; Caspase 1; Chlorquinaldol; Cytokines; Dermatitis; Female; Imiquimod; Inflammasomes; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Nucleotides; Psoriasis; Pyrin Domain | 2022 |
Effect on ethanolic extract of sechiumedule fruitson imquimod-induced psoriasis like dermatitis in wistar rats.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Male; Mice; Psoriasis; Rats; Rats, Wistar; Skin | 2022 |
Cyclosporine and Pentoxifylline laden tailored niosomes for the effective management of psoriasis: In-vitro optimization, Ex-vivo and animal study.
Topics: Animals; Cholesterol; Cyclosporine; Imiquimod; Liposomes; Mice; Particle Size; Pentoxifylline; Polysorbates; Psoriasis; Surface-Active Agents | 2022 |
Decreasing GDF15 Promotes Inflammatory Signals and Neutrophil Infiltration in Psoriasis Models.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Psoriasis; Skin | 2023 |
NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice.
Topics: Alanine; Animals; Asparagine; Aspartic Acid; Cytokines; Disease Models, Animal; Glucose; Histidine; Imiquimod; Interleukin-17; Interleukin-23; Interleukin-8; Magnetic Resonance Spectroscopy; Mice; Moxibustion; Psoriasis; Skin; Taurine; Triglycerides; Valine | 2023 |
Imiquimod-induced ex vivo model of psoriatic human skin via interleukin-17A signalling of T cells and Langerhans cells.
Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Langerhans Cells; Psoriasis; Skin; T-Lymphocytes | 2022 |
Inhibition of JAK1/STAT3 pathway by 2-methoxyestradiol ameliorates psoriatic features in vitro and in an imiquimod-induced psoriasis-like mouse model.
Topics: 2-Methoxyestradiol; Animals; Cell Proliferation; Dermatitis; Disease Models, Animal; Endothelial Cells; Humans; Imiquimod; Interleukin-17; Janus Kinase 1; Keratinocytes; Mercaptoethanol; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ointments; Psoriasis; Skin; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2022 |
[The number of regulatory T cells in spleen and serum-related cytokines increase in mouse model of psoriasis induced by imiquimod].
Topics: Animals; Cytokines; Disease Models, Animal; Female; Imiquimod; Interleukin-10; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Spleen; T-Lymphocytes, Regulatory; Transforming Growth Factor beta1 | 2022 |
Novel RNA polymerase I inhibitor CX-5461 suppresses imiquimod-induced experimental psoriasis.
Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Disease Models, Animal; Endothelial Cells; Imiquimod; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Psoriasis; RNA Polymerase I; Skin | 2023 |
Oestrogen inhibits psoriasis-like dermatitis induced by imiquimod in mice in relation to increased IL-10 producing cells despite elevated expression of IL-22, IL-23, IL-17 mRNA.
Topics: Animals; Dermatitis; Disease Models, Animal; Estrogens; Female; Imiquimod; Inflammation; Interleukin-10; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger | 2023 |
Lenalidomide attenuates IMQ-induced inflammation in a mouse model of psoriasis.
Topics: Animals; Disease Models, Animal; Imiquimod; Inflammation; Lenalidomide; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Skin; Tumor Microenvironment | 2022 |
Efficient local delivery of FK506 using blocking patches in psoriasis.
Topics: Administration, Cutaneous; Animals; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Tacrolimus | 2023 |
Reduction of Methyltransferase-like 3-Mediated RNA N6-Methyladenosine Exacerbates the Development of Psoriasis Vulgaris in Imiquimod-Induced Psoriasis-like Mouse Model.
Topics: Adenosine; Animals; Disease Models, Animal; Humans; Imiquimod; Inflammation; Methyltransferases; Mice; Psoriasis; RNA; RNA, Messenger | 2022 |
Eupatilin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like skin lesions in mice via the p38 MAPK/NF-κB signaling pathway.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Imiquimod; Interleukin-17; Interleukin-23; Interleukin-6; Keratinocytes; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Psoriasis; Skin; Skin Diseases; Tumor Necrosis Factor-alpha | 2023 |
Transcutaneous amorphous preparation co-delivering curcumin and modified aptamer as a synergistic approach for the amelioration of psoriasis-like skin inflammation.
Topics: Curcumin; Glycyrrhizic Acid; Humans; Imiquimod; Psoriasis; Silicon Dioxide | 2023 |
Knockdown of Bcl-3 alleviates psoriasis and dyslipidemia comorbidity by regulating Akt pathway.
Topics: Animals; Apolipoproteins E; Cholesterol; Comorbidity; Disease Models, Animal; Dyslipidemias; Glycogen Synthase Kinase 3 beta; Imiquimod; Leukemia, B-Cell; Mice; Mice, Inbred BALB C; NF-kappa B; Proto-Oncogene Proteins c-akt; Psoriasis; RNA, Small Interfering; Skin | 2022 |
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Topics: Animals; Dermatitis; Disease Models, Animal; Guinea Pigs; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Rabbits; Skin | 2023 |
CCN1 upregulates IL-36 via AKT/NF-κB and ERK/CEBP β-mediated signaling pathways in psoriasis-like models.
Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Proto-Oncogene Proteins c-akt; Psoriasis; Signal Transduction; Skin | 2023 |
Tryptanthrin ameliorates imiquimod-induced psoriasis in mice by suppressing inflammation and oxidative stress via NF-κB/MAPK/Nrf2 pathways.
Topics: Animals; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Psoriasis; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2023 |
Role of Type I Cannabinoid Receptor in Sensory Neurons in Psoriasiform Skin Inflammation and Pruritus.
Topics: Animals; Eczema; Imiquimod; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Pruritus; Psoriasis; Receptors, Cannabinoid; Sensory Receptor Cells; Substance P | 2023 |
Mupirocin blocks imiquimod-induced psoriasis-like skin lesion by inhibiting epidermal isoleucyl-tRNA synthetase.
Topics: Animals; Humans; Imiquimod; Isoleucine-tRNA Ligase; Mice; Mice, Inbred C57BL; Mupirocin; Psoriasis; Skin Diseases | 2022 |
Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis.
Topics: Animals; Disease Models, Animal; Disease Progression; Eczema; Imiquimod; Mice; NADP; NADPH Oxidases; Neutrophils; Psoriasis | 2022 |
Kaempferol modulates IFN-γ induced JAK-STAT signaling pathway and ameliorates imiquimod-induced psoriasis-like skin lesions.
Topics: Animals; Disease Models, Animal; Imiquimod; Interferon-gamma; Janus Kinases; Kaempferols; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Signal Transduction; Skin; STAT Transcription Factors; Suppressor of Cytokine Signaling Proteins | 2023 |
A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice.
Topics: Animals; Dermatitis; Diet, High-Fat; Disease Models, Animal; Imiquimod; Ketocholesterols; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxysterols; Psoriasis | 2022 |
Lipidomic profiling reveals metabolic signatures in psoriatic skin lesions.
Topics: Animals; Ceramides; Disease Models, Animal; Imiquimod; Inflammation; Keratinocytes; Lipidomics; Lipids; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
FcγRIIB inhibits inflammation in a murine model of psoriasis.
Topics: Animals; Dermatitis; Disease Models, Animal; Forkhead Transcription Factors; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2022 |
Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines.
Topics: Animals; Cell Proliferation; Cytokines; Humans; Imiquimod; Interleukin-8; Melanins; Melanocytes; Mice; Microphthalmia-Associated Transcription Factor; Psoriasis; RNA, Small Interfering; Tumor Necrosis Factor-alpha | 2022 |
Development and evaluation emulgel for effective management of the imiquimod-induced psoriasis.
Topics: Animals; Body Weight; Disease Models, Animal; Imiquimod; Inflammation; Male; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
Inhibition of Serum- and Glucocorticoid-Regulated Protein Kinase-1 Aggravates Imiquimod-Induced Psoriatic Dermatitis and Enhances Proinflammatory Cytokine Expression through the NF-kB Pathway.
Topics: Animals; Cytokines; Dermatitis; Glucocorticoids; Imiquimod; Mice; NF-kappa B; Protein Kinases; Psoriasis; Toll-Like Receptor 7 | 2023 |
Comparative studies on mannan and imiquimod induced experimental plaque psoriasis inflammation in inbred mice.
Topics: Animals; Dexamethasone; Disease Models, Animal; Imiquimod; Inflammation; Mannans; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
Alleviation of imiquimod-induced psoriasis-like symptoms in Rorα-deficient mouse skin.
Topics: Animals; Imiquimod; Inflammation; Keratinocytes; Mice; Psoriasis; Skin | 2023 |
Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.
Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Group IV Phospholipases A2; Imiquimod; Lipid Metabolism; Mice; Phospholipids; Psoriasis | 2022 |
CCR4
Topics: Animals; Arthritis, Psoriatic; CD8-Positive T-Lymphocytes; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, Antigen, T-Cell; Receptors, CCR4; Skin Diseases | 2023 |
Benvitimod inhibits MCM6-meditated proliferation of keratinocytes by regulating the JAK/STAT3 pathway.
Topics: Animals; Cell Proliferation; Imiquimod; Keratinocytes; Mice; Psoriasis; Resorcinols | 2023 |
Potential skin health promoting benefits of costunolide: a therapeutic strategy to improve skin inflammation in imiquimod-induced psoriasis.
Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Health Promotion; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Sesquiterpenes; Skin | 2023 |
Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity.
Topics: Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Psoriasis; Skin | 2023 |
Topical Delivery of ROS-Responsive Methotrexate Prodrug Nanoassemblies by a Dissolvable Microneedle Patch for Psoriasis Therapy.
Topics: Animals; Imiquimod; Methotrexate; Mice; NF-kappa B; Polyesters; Prodrugs; Psoriasis; Reactive Oxygen Species; Skin | 2023 |
Tacrolimus and paclitaxel co-loaded O/O ointment without surfactant: Synergistic combinations for the treatment of psoriasis.
Topics: Humans; Imiquimod; Ointments; Paclitaxel; Psoriasis; Pulmonary Surfactants; Surface-Active Agents; Tacrolimus | 2023 |
PD-L1 Enhanced by cis-Urocanic Acid on Langerhans Cells Inhibits Vγ4
Topics: Animals; B7-H1 Antigen; Dermatitis; Humans; Imiquimod; Inflammation; Interleukin-23; Langerhans Cells; Mice; Psoriasis; Ultraviolet Rays; Urocanic Acid | 2023 |
Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.
Topics: Adenylyl Cyclases; Animals; Humans; Imiquimod; Inflammation; Interleukin-17; Mice; Mice, Knockout; Microbiota; Psoriasis; T-Lymphocytes, Regulatory | 2023 |
IL-33-mediated activation of mast cells is involved in the progression of imiquimod-induced psoriasis-like dermatitis.
Topics: Animals; Dermatitis; Imiquimod; Interleukin-33; Mast Cells; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
Oral exposure to citrinin significantly exacerbates the pathophysiology of a mouse model of imiquimod-induced psoriasis via direct activation of dendritic cell.
Topics: Aminoquinolines; Animals; Citrinin; Dendritic Cells; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression.
Topics: Animals; Apoptosis; Cell Adhesion Molecules; Cell Line; Cell Proliferation; Humans; Imiquimod; Keratinocytes; Mice; Psoriasis; Up-Regulation | 2023 |
Aberrant promoter methylation of Wnt inhibitory factor-1 gene is a potential target for treating psoriasis.
Topics: Animals; Decitabine; Disease Models, Animal; DNA Methylation; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Promoter Regions, Genetic; Psoriasis; Skin | 2023 |
Topical application of imatinib mesylate ameliorated psoriasis-like skin lesions in imiquimod-induced murine model via angiogenesis inhibition.
Topics: Animals; Disease Models, Animal; Humans; Imatinib Mesylate; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases; Vascular Endothelial Growth Factor A | 2023 |
Fufang Shengdi mixture alleviates psoriasis-like skin inflammation via promoting Annexin-A proteins expression.
Topics: Animals; Annexins; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases; Tumor Necrosis Factor-alpha | 2023 |
The Impact of Proinflammatory Cytokines and Imiquimod on GLUT1 in HaCaT Keratinocytes - a Potential Anti-Psoriatic Therapeutic Target?
Topics: Animals; Cytokines; Disease Models, Animal; Glucose Transporter Type 1; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Tumor Necrosis Factor-alpha | 2023 |
Palbociclib blocks neutrophilic phosphatidylinositol 3-kinase activity to alleviate psoriasiform dermatitis.
Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis | 2023 |
Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis.
Topics: Animals; Imiquimod; Interleukins; Mice; Mice, Knockout; Myeloid-Derived Suppressor Cells; Nitric Oxide Synthase Type II; Psoriasis | 2023 |
Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin.
Topics: Animals; Dermatitis; Imiquimod; Inflammation; Mice; Psoriasis; Receptors, Cell Surface; Skin; Skin Diseases; T-Lymphocytes, Regulatory | 2023 |
Impact of Obesity on the IL-6 Immune Marker and Th17 Immune Cells in C57BL/6 Mice Models with Imiquimod-Induced Psoriasis.
Topics: Animals; Biomarkers; Cytokines; Disease Models, Animal; Imiquimod; Interleukin-6; Mice; Mice, Inbred C57BL; Obesity; Psoriasis; Skin; Th17 Cells | 2023 |
Topics: Caspase 1; Caspases; Cornus; Dermatitis; DNA-Binding Proteins; HEK293 Cells; Humans; Imiquimod; Inflammasomes; Inflammation; Interleukin-1beta; NLR Family, Pyrin Domain-Containing 3 Protein; Plant Extracts; Psoriasis; Seeds | 2023 |
Specific Activation of CB2R Ameliorates Psoriasis-Like Skin Lesions by Inhibiting Inflammation and Oxidative Stress.
Topics: Animals; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Kelch-Like ECH-Associated Protein 1; Keratinocytes; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oxidative Stress; Psoriasis; Skin; Skin Diseases | 2023 |
Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance.
Topics: Animals; Anti-Inflammatory Agents; Diosmin; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; MicroRNAs; Nanoparticles; NF-kappa B; Proto-Oncogene Proteins c-akt; Psoriasis; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Skin; Toll-Like Receptor 7; TOR Serine-Threonine Kinases | 2023 |
Lysophosphatidylcholine facilitates the pathogenesis of psoriasis through activating keratinocytes and T cells differentiation via glycolysis.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Imiquimod; Keratinocytes; Lysophosphatidylcholines; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases | 2023 |
Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
Topics: Animals; Cell Proliferation; Cytokines; Imiquimod; Keratinocytes; Mice; Psoriasis | 2023 |
Translation-dependent skin hyperplasia is promoted by type 1/17 inflammation in psoriasis.
Topics: Animals; Disease Models, Animal; Eukaryotic Initiation Factor-4E; Humans; Hyperplasia; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Tumor Necrosis Factor-alpha | 2023 |
Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.
Topics: Adenylyl Cyclases; Animals; Disease Models, Animal; Eczema; Imiquimod; Inflammation; Mice; Psoriasis; Skin; Th17 Cells | 2023 |
Protein Kinase CK2 Promotes Proliferation, Abnormal Differentiation, and Proinflammatory Cytokine Production of Keratinocytes via Regulation of STAT3 and Akt Pathways in Psoriasis.
Topics: Animals; Casein Kinase II; Cell Differentiation; Cell Proliferation; Cytokines; Humans; Imiquimod; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-akt; Psoriasis; Skin; STAT3 Transcription Factor | 2023 |
Etanercept ameliorates psoriasis progression through regulating high mobility group box 1 pathway.
Topics: Animals; Disease Models, Animal; Etanercept; HMGB1 Protein; Imiquimod; Inflammation; Keratinocytes; Lipopolysaccharides; Mice; Psoriasis; Receptor for Advanced Glycation End Products | 2023 |
Piperine ameliorates psoriatic skin inflammation by inhibiting the phosphorylation of STAT3.
Topics: Alkaloids; Animals; Cytokines; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Phosphorylation; Psoriasis; Skin; STAT3 Transcription Factor | 2023 |
Topics: Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukins; Keratinocytes; Mice; Psoriasis; Skin; TEA Domain Transcription Factors; Th1 Cells; Th17 Cells; Transcription Factor AP-2 | 2023 |
Topical histone deacetylase 1 inhibitor Entinostat ameliorates psoriasiform dermatitis through suppression of IL-17A response.
Topics: Animals; Disease Models, Animal; Eczema; Histone Deacetylase 1; Humans; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
RNA sequencing and metabolic analysis of imiquimod-induced psoriasis-like mice with chronic restrain stress.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Sequence Analysis, RNA; Skin | 2023 |
TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System.
Topics: Adenosine Triphosphate; Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Knockout; Neuropeptides; Psoriasis; Skin; TRPV Cation Channels | 2023 |
SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages.
Topics: Animals; Dermatitis; Imiquimod; Inflammation; Interleukin-23; Macrophages; Mice; Psoriasis; Sirtuin 3; Toll-Like Receptor 7; X-Box Binding Protein 1 | 2023 |
Centella asiatica alleviates psoriasis through JAK/STAT3-mediated inflammation: An in vitro and in vivo study.
Topics: Animals; Antioxidants; Centella; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Skin | 2023 |
SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Homeostasis; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Nucleotide Transport Proteins; Psoriasis | 2023 |
Benzoylaconitine Alleviates Progression of Psoriasis via Suppressing STAT3 Phosphorylation in Keratinocytes.
Topics: Animals; Cell Proliferation; Cytokines; Disease Models, Animal; Imiquimod; Keratinocytes; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phosphorylation; Psoriasis; Skin; Tumor Necrosis Factor-alpha | 2023 |
Liangxue Jiedu formula improves imiquimod-induced psoriasiform dermatitis with circadian desynchrony by regulating Th17 cell differentiation based on network pharmacological analysis.
Topics: Animals; Cell Differentiation; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Th17 Cells | 2023 |
Anti-interleukin 33 treatment alleviates psoriatic dermatitis in mice induced imiquimod.
Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-33; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
Discovery of 5-((1H-indazol-3-yl) methylene)-2-thioxoimidazolidin-4-one derivatives as a new class of AHR agonists with anti-psoriasis activity in a mouse model.
Topics: Animals; Imiquimod; Indazoles; Mice; Psoriasis; Receptors, Aryl Hydrocarbon; Skin | 2023 |
NEK2 overexpression aggravates IL-22-induced keratinocyte proliferation and cytokine level increases and IMQ-induced psoriasis-like dermatitis.
Topics: Animals; Cell Proliferation; Cytokines; Dermatitis; DNA; Imiquimod; Inflammation; Interleukin-22; Keratinocytes; Mice; Protein Kinases; Psoriasis; Skin | 2023 |
PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes.
Topics: Animals; Aromatase; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Psoriasis; RNA, Messenger; Skin | 2023 |
Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis.
Topics: Animals; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Water | 2023 |
Self-assembled Gallic acid loaded lecithin-chitosan hybrid nanostructured gel as a potential tool against imiquimod-induced psoriasis.
Topics: Chitosan; Gallic Acid; Humans; Imiquimod; Lecithins; Nanoparticles; Particle Size; Psoriasis | 2023 |
RasGRP1 influences imiquimod-induced psoriatic inflammation via T-cell activation in mice.
Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Vascular Endothelial Growth Factor A | 2023 |
An alkaloid-rich phytopharmaceutical prepared from Qing Dai against IL-17A-induced psoriasis.
Topics: Alkaloids; Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Quality of Life; Skin | 2024 |
Gentiopicroside-Loaded Chitosan Nanoparticles Inhibit TNF-α-Induced Proliferation and Inflammatory Response in HaCaT Keratinocytes and Ameliorate Imiquimod-Induced Dermatitis Lesions in Mice.
Topics: Animals; Cell Proliferation; Chitosan; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2023 |
IL-17A exacerbates psoriasis in a STAT3 overexpressing mouse model.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-17; Mice; Psoriasis; Skin | 2023 |
Qingre Lishi Decoction ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice by regulating the Treg-DC-Th17 axis and inhibiting MAPK-mediated DC maturation.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Psoriasis; Skin; Skin Diseases; T-Lymphocytes, Regulatory; Th17 Cells | 2024 |
Evidence on the therapeutic role of thiolutin in imiquimod-induced psoriasis-like skin inflammation in mice.
Topics: Animals; Dermatitis; Forkhead Transcription Factors; Imiquimod; Inflammasomes; Inflammation; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis | 2023 |
Characterization and active component identification of Premna herbacea roxb. root extract reveals anti-inflammatory effect and amelioration of imiquimod induced psoriasis via modulation of macrophage inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Macrophages; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Plant Extracts; Psoriasis; Skin | 2023 |
Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Integrin alpha Chains; Mice; Psoriasis; Skin | 2023 |
Tranexamic acid improves psoriasis-like skin inflammation: Evidence from in vivo and in vitro studies.
Topics: Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammasomes; Inflammation; Interleukin-17; Keratin-17; Keratinocytes; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Skin; Tranexamic Acid | 2023 |
Resting-state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis-like skin lesions.
Topics: Animals; Anxiety; Brain; Humans; Imiquimod; Magnetic Resonance Imaging; Mice; Psoriasis | 2023 |
Imiquimod-induced extensive plaque psoriasis.
Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease in mice.
Topics: Animals; Glycyrrhetinic Acid; Glycyrrhizic Acid; Imiquimod; Interleukin-17; Interleukin-23; Mice; Ointments; Psoriasis | 2023 |
Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis.
Topics: Animals; Dermatitis; Disulfiram; Gasdermins; Imiquimod; Inflammation; Keratinocytes; Ki-67 Antigen; Mice; Psoriasis; Pyroptosis | 2023 |
Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice.
Topics: Animals; Cannabidiol; Dietary Supplements; Disease Models, Animal; Erythema; Humans; Imiquimod; Inositol; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.
Topics: Animals; Dermatitis; Edar Receptor; Humans; Imiquimod; Keratinocytes; Mice; NF-kappa B; Psoriasis; Receptors, Ectodysplasin; Receptors, Tumor Necrosis Factor | 2023 |
Dietary Fiber Inulin Improves Murine Imiquimod-Induced Psoriasis-like Dermatitis.
Topics: Animals; Dermatitis; Imiquimod; Interleukin-17; Inulin; Ki-67 Antigen; Mice; Propionates; Psoriasis; RNA, Ribosomal, 16S | 2023 |
MicroRNA-125a-5p regulates the effect of Tregs on Th1 and Th17 through targeting ETS-1/STAT3 in psoriasis.
Topics: Animals; Cell Differentiation; Humans; Imiquimod; Mice; MicroRNAs; Psoriasis; STAT3 Transcription Factor; T-Lymphocytes, Regulatory; Th17 Cells | 2023 |
Di-(2-ethylhexyl) phthalate aggravates psoriasis-like skin lesions: In vitro and in vivo evaluation.
Topics: Animals; Diethylhexyl Phthalate; Humans; Imiquimod; Inflammation; Mice; p38 Mitogen-Activated Protein Kinases; Psoriasis; Skin; Skin Diseases | 2023 |
Therapeutic effects of candesartan in inflammatory skin disorders by suppressing Th17 differentiation.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Benzoates; Cell Differentiation; Dermatitis, Atopic; Humans; Imiquimod; PPAR gamma; Psoriasis; Skin; Telmisartan; Th17 Cells | 2023 |
Design, synthesis and characterization of a novel multicomponent salt of bexarotene with metformin and application in ameliorating psoriasis with T2DM.
Topics: Animals; Bexarotene; Diabetes Mellitus, Type 2; Drug Combinations; Humans; Imiquimod; Metformin; Mice; Psoriasis; Sodium Chloride; Tetrahydronaphthalenes | 2023 |
Cannabidiol-Loaded Lipid-Stabilized Nanoparticles Alleviate Psoriasis Severity in Mice: A New Approach for Improved Topical Drug Delivery.
Topics: Animals; Cannabidiol; Disease Models, Animal; Emulsions; Imiquimod; Interleukin-17; Lipids; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; Rats; Skin | 2023 |
Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression.
Topics: Animals; Biomarkers; Glucocorticoids; Humans; Imiquimod; Immunosuppression Therapy; Mice; Psoriasis; Skin; Toll-Like Receptor 7; Transcriptome; Zebrafish | 2023 |
Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse.
Topics: Animals; B7-H1 Antigen; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Imiquimod; Immune Checkpoint Inhibitors; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Pruritus; Psoriasis; Spinal Cord Dorsal Horn | 2023 |
Topical anti-TNF-a ssDNA aptamer decreased the imiquimod induced psoriatic inflammation in BALB/c mice.
Topics: Animals; Disease Models, Animal; DNA, Single-Stranded; Imiquimod; Inflammation; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger; Skin; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor 1 Antagonists for the Treatment of Psoriasis.
Topics: Animals; Chemokines; Cricetinae; Cricetulus; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
Development of a Deep Eutectic Solvent-Assisted Kaempferol Hydrogel: A Promising Therapeutic Approach for Psoriasis-like Skin Inflammation.
Topics: Animals; Antioxidants; Deep Eutectic Solvents; Disease Models, Animal; Hydrogels; Imiquimod; Inflammation; Kaempferols; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2023 |
Quality-by-Design Approach for Investigating the Efficacy of Tacrolimus and Hyaluronic Acid-Loaded Ethosomal Gel in Dermal Management of Psoriasis: In Vitro, Ex Vivo, and In Vivo Evaluation.
Topics: Administration, Cutaneous; Humans; Hyaluronic Acid; Imiquimod; Psoriasis; Skin; Tacrolimus | 2023 |
Preparation and characterization of solid lipid nanoparticles encapsulated noscapine and evaluation of its protective effects against imiquimod-induced psoriasis-like skin lesions.
Topics: Humans; Imiquimod; Inflammation; Lipids; Nanoparticles; Noscapine; Psoriasis; Skin | 2023 |
LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice.
Topics: Animals; Cytokines; Imiquimod; Mice; Mice, Inbred C57BL; Psoriasis; Sirtuin 1; Th17 Cells | 2023 |
Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis.
Topics: Animals; Disease Models, Animal; Imiquimod; Mice; Microglia; Pruritus; Psoriasis; Spinal Cord | 2023 |
Staphylococcus warneri strain XSB102 exacerbates psoriasis and promotes keratinocyte proliferation in imiquimod-induced psoriasis-like dermatitis mice.
Topics: Animals; Cell Proliferation; Dermatitis; Disease Models, Animal; Homeodomain Proteins; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Repressor Proteins; Skin; Staphylococcus | 2023 |
Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments.
Topics: Animals; Antipruritics; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred C57BL; Pruritus; Psoriasis; Rats; Rats, Wistar; Skin | 2023 |
Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation.
Topics: Animals; Antibodies, Neutralizing; CD4-Positive T-Lymphocytes; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Interleukin-7; Lymph Nodes; Lymphatic Vessels; Male; Mice; Mice, Inbred C57BL; Organ Specificity; Oxazolone; Psoriasis; Receptors, Interleukin-7; Signal Transduction; Skin; Tetradecanoylphorbol Acetate | 2019 |
Kaempferol attenuates imiquimod-induced psoriatic skin inflammation in a mouse model.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-6; Kaempferols; Mice, Inbred BALB C; Psoriasis; Signal Transduction; Skin | 2019 |
Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model.
Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Female; Folic Acid Antagonists; Imiquimod; Immunosuppressive Agents; Liposomes; Methotrexate; Mice, Inbred BALB C; Psoriasis | 2019 |
Targeting the IL-17 Receptor Using Liposomal Spherical Nucleic Acids as Topical Therapy for Psoriasis.
Topics: Administration, Cutaneous; Animals; Biomarkers; Cells, Cultured; Disease Models, Animal; DNA, Antisense; Gene Knockdown Techniques; Humans; Imiquimod; Keratinocytes; Liposomes; Mice; Nanospheres; Primary Cell Culture; Psoriasis; Receptors, Interleukin-17; RNA, Messenger; Severity of Illness Index; Skin | 2020 |
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
Topics: A549 Cells; Animals; Antibodies, Blocking; Antibodies, Monoclonal; Cell Line, Tumor; Disease Models, Animal; HEK293 Cells; Humans; Imiquimod; Inflammation; Interleukin-1; Interleukin-1 Receptor Accessory Protein; Interleukin-1beta; Interleukin-33; Male; Mice; Mice, Inbred C57BL; Ovalbumin; Peritonitis; Pneumonia; Psoriasis; Signal Transduction; Uric Acid | 2019 |
Artesunate alleviates imiquimod-induced psoriasis-like dermatitis in BALB/c mice.
Topics: Animals; Anti-Inflammatory Agents; Artesunate; Dermatitis; Imiquimod; Intraepithelial Lymphocytes; Lymph Nodes; Male; Mice, Inbred BALB C; Psoriasis; Skin; Th17 Cells | 2019 |
Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis.
Topics: Adult; Animals; Blood Platelets; Humans; Imiquimod; Mice; Mice, Inbred C57BL; Neutrophils; Platelet Activation; Platelet Aggregation; Platelet Count; Psoriasis; Skin | 2019 |
Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation.
Topics: Administration, Cutaneous; Animals; Cell Line; Drug Delivery Systems; Humans; Imiquimod; Indoles; Male; Methanol; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; NF-kappa B; Nitrobenzenes; Phosphorylation; Psoriasis; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2019 |
Ginsenoside Rg1 abolish imiquimod-induced psoriasis-like dermatitis in BALB/c mice via downregulating NF-κB signaling pathway.
Topics: Animals; Dermatitis; Disease Models, Animal; Down-Regulation; Ginsenosides; Humans; Imiquimod; Interleukin-22; Interleukin-23; Interleukins; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2019 |
[Esculentoside reduces expression of Th17 cell-related cytokines in the imiquimod-induced psoriasis-like dermatitis mouse model].
Topics: Animals; Cytokines; Dermatitis; Female; Imiquimod; Mice; Mice, Inbred BALB C; Oleanolic Acid; Psoriasis; Random Allocation; Saponins; Skin; Th17 Cells | 2019 |
Kan-Lu-Hsiao-Tu-Tan, a traditional Chinese medicine formula, inhibits human neutrophil activation and ameliorates imiquimod-induced psoriasis-like skin inflammation.
Topics: Animals; Cells, Cultured; Drugs, Chinese Herbal; Humans; Imiquimod; Inflammation; Male; Medicine, Chinese Traditional; Mice; Neutrophil Activation; Neutrophils; Psoriasis | 2020 |
The Influence of Ketogenic Diets on Psoriasiform-Like Skin Inflammation.
Topics: 3-Hydroxybutyric Acid; Animals; Biopsy; Blood Glucose; Diet, Ketogenic; Disease Models, Animal; Fatty Acids, Omega-3; Humans; Imiquimod; Male; Mice; Psoriasis; Severity of Illness Index; Skin; Triglycerides; Weight Gain | 2020 |
Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis.
Topics: Animals; Cytokines; Disease Models, Animal; Imiquimod; Male; Mice; Mice, Inbred BALB C; Peptides; Psoriasis; RANK Ligand | 2019 |
Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Gold; Humans; Imiquimod; Immunity; Methotrexate; Mice; Mice, Inbred C57BL; Nanoparticles; Psoriasis; Skin; Th17 Cells; Xenograft Model Antitumor Assays | 2020 |
Biological depletion of neutrophils attenuates pro-inflammatory markers and the development of the psoriatic phenotype in a murine model of psoriasis.
Topics: Animals; Biomarkers; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Leukocyte Reduction Procedures; Mice; Mice, Inbred BALB C; Neutrophils; Phenotype; Psoriasis | 2020 |
D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway.
Topics: Animals; Anti-Inflammatory Agents; Imiquimod; Inflammation; Inositol; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis | 2019 |
Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models.
Topics: Animals; Disease Models, Animal; Female; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Necroptosis; Protein Kinases; Psoriasis; Reactive Oxygen Species; Skin; Strophanthins | 2020 |
Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis.
Topics: Animals; Cell Line; Cell Proliferation; Cytokines; Disease Models, Animal; Gene Expression; Humans; Imiquimod; Inflammation; Interleukin-6; Keratinocytes; Male; Mice; Mice, Knockout; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Psoriasis; RNA, Messenger; Severity of Illness Index; Th17 Cells; TRPV Cation Channels | 2020 |
Calcipotriol and betamethasone dipropionate exhibit different immunomodulatory effects on imiquimod-induced murine psoriasiform dermatitis.
Topics: Administration, Cutaneous; Animals; Betamethasone; Calcitriol; Cytokines; Dermatologic Agents; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Gene Expression Regulation; Glucocorticoids; Humans; Imiquimod; Mice; Ointments; Psoriasis; Skin; Th1 Cells; Th17 Cells | 2020 |
Topical administration of nanocarrier miRNA-210 antisense ameliorates imiquimod-induced psoriasis-like dermatitis in mice.
Topics: Administration, Cutaneous; Animals; Antagomirs; Disease Models, Animal; Drug Carriers; Female; Gels; Humans; Imiquimod; Lipoproteins, HDL; Mice; MicroRNAs; Nanoparticles; Psoriasis; Skin; Th1 Cells; Th17 Cells | 2020 |
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line; Cell Proliferation; Cytokines; Diosgenin; Disease Models, Animal; Female; Human Umbilical Vein Endothelial Cells; Humans; Imiquimod; Keratinocytes; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Receptors, Interleukin | 2020 |
Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dictamnus; Female; Imiquimod; Mice; Mice, Inbred C57BL; Plant Bark; Plant Extracts; Psoriasis; Skin; STAT3 Transcription Factor; T-Lymphocytes, Helper-Inducer | 2019 |
CD200-CD200R1 signalling attenuates imiquimod-induced psoriatic inflammation by inhibiting the activation of skin inflammatory macrophages.
Topics: Animals; Antigens, CD; Cell Movement; Cells, Cultured; Coculture Techniques; Humans; Imiquimod; Interleukin-1beta; Interleukin-6; Keratinocytes; Macrophages; Male; Mice; NF-kappa B; Orexin Receptors; Primary Cell Culture; Psoriasis; Signal Transduction; Skin | 2020 |
Acitretin inhibits IL-17A-induced IL-36 expression in keratinocytes by down-regulating IκBζ.
Topics: Acitretin; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Down-Regulation; Female; Humans; I-kappa B Kinase; Imiquimod; Interleukin-1; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis | 2020 |
Mechanism of danshensu-induced inhibition of abnormal epidermal proliferation in psoriasis.
Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Animals; Apoptosis; Cell Cycle Proteins; Cell Line; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epidermis; Female; G1 Phase Cell Cycle Checkpoints; Humans; Imiquimod; Injections, Intraperitoneal; Keratinocytes; Lactates; Mice; Psoriasis; Salvia miltiorrhiza; Transcription Factors; YAP-Signaling Proteins | 2020 |
Tussilagonone Ameliorates Psoriatic Features in Keratinocytes and Imiquimod-Induced Psoriasis-Like Lesions in Mice via NRF2 Activation.
Topics: Administration, Cutaneous; Adult; Animals; Anti-Inflammatory Agents; Cell Line; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Imiquimod; Keratinocytes; Mice; NF-E2-Related Factor 2; Pentanoic Acids; Psoriasis; Sesquiterpenes; Tussilago | 2020 |
Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; Fluorescence Resonance Energy Transfer; Imiquimod; Mice; Mice, Inbred BALB C; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Quinolines; Structure-Activity Relationship; Sulfonamides; Th17 Cells | 2020 |
Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2/STAT3 signal pathways.
Topics: Animals; Cell Line; Cell Proliferation; Cyclosporine; Cytokines; Dermatitis; Humans; Imiquimod; Inflammation; Janus Kinase 2; Keratinocytes; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Models, Animal; Psoriasis; Quercetin; Receptor, Notch1; Signal Transduction; Skin; STAT3 Transcription Factor; T-Lymphocytes; Transcription Factors | 2020 |
PSORI-CM02 formula alleviates imiquimod-induced psoriasis via affecting macrophage infiltration and polarization.
Topics: Adjuvants, Immunologic; Animals; Cell Differentiation; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Imiquimod; Macrophages; Mice; Psoriasis; RAW 264.7 Cells; RNA, Messenger; Skin | 2020 |
Aryl Hydrocarbon Receptor in Cutaneous Vascular Endothelial Cells Restricts Psoriasis Development by Negatively Regulating Neutrophil Recruitment.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Biopsy; Disease Models, Animal; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Female; Humans; Imiquimod; Intercellular Adhesion Molecule-1; Interleukin-23; Male; Mice; Mice, Knockout; Neutrophil Infiltration; Psoriasis; Receptors, Aryl Hydrocarbon; Skin | 2020 |
Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation.
Topics: Animals; Apoptosis; Cell Proliferation; Chemokines; Dioxolanes; Epidermis; Epigenesis, Genetic; HaCaT Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Imiquimod; Inflammation; Keratin-17; Keratinocytes; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Models, Biological; Phosphorylation; Protein Binding; Psoriasis; RAW 264.7 Cells; Skin; STAT3 Transcription Factor | 2020 |
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Regulates Epidermal Keratinization under Psoriatic Skin Inflammation.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chimera; Epidermis; Female; Homeostasis; Humans; Imiquimod; Immunohistochemistry; Inflammation; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Parakeratosis; Psoriasis; Skin | 2020 |
Effects of tumor necrosis factor-like ligand 1A (TL1A) on imiquimod-induced psoriasiform skin inflammation in mice.
Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Male; Mice; Psoriasis; Signal Transduction; Skin; Tumor Necrosis Factor Ligand Superfamily Member 15; Tumor Necrosis Factor-alpha | 2020 |
Bruton's tyrosine kinase inhibitor suppresses imiquimod-induced psoriasis-like inflammation in mice through regulation of IL-23/IL-17A in innate immune cells.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Immunity, Innate; Interleukin-17; Interleukin-23; Intraepithelial Lymphocytes; Male; Mice; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrazoles; Pyrimidines; Signal Transduction; Skin | 2020 |
4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.
Topics: 4-1BB Ligand; Animals; Cell Line; Female; Imiquimod; Inflammation; Interleukin-17; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Psoriasis; RAW 264.7 Cells; Signal Transduction; Skin; T-Lymphocytes, Regulatory | 2020 |
Diet-induced obesity exacerbates imiquimod-mediated psoriasiform dermatitis in anti-PD-1 antibody-treated mice: Implications for patients being treated with checkpoint inhibitors for cancer.
Topics: Animals; Diet, Western; Disease Models, Animal; Female; Humans; Imiquimod; Immune Checkpoint Inhibitors; Mice; Neoplasms; Obesity; Programmed Cell Death 1 Receptor; Psoriasis; Risk Factors; Skin; Symptom Flare Up | 2020 |
PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation.
Topics: Animals; beta Catenin; Cytokines; Disease Models, Animal; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Polydeoxyribonucleotides; Psoriasis; Receptor, Adenosine A2A; Skin; Wnt Signaling Pathway | 2020 |
Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis.
Topics: Administration, Cutaneous; Animals; Delayed-Action Preparations; Disease Models, Animal; Down-Regulation; Drug Synergism; Female; Imiquimod; Liposomes; Male; Mice; Mice, Inbred BALB C; Nanoparticles; NIH 3T3 Cells; Particle Size; Psoriasis; RNA, Small Interfering; Tacrolimus; Tumor Necrosis Factor-alpha | 2020 |
Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation.
Topics: Acrylamides; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Female; HaCaT Cells; Humans; Imidazoles; Imiquimod; Indoles; Inflammation Mediators; Keratinocytes; Mice, Inbred BALB C; Necroptosis; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Psoriasis; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Skin; Sulfonamides | 2020 |
Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides.
Topics: Animals; Antimicrobial Cationic Peptides; Chemokine CCL20; Disease Models, Animal; Down-Regulation; Epidermis; Flavonoids; Humans; Hyperplasia; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukins; Keratinocytes; Male; MAP Kinase Signaling System; Mice, Inbred BALB C; NF-kappa B; Phosphorylation; Psoriasis; RNA, Messenger; Skin; Tumor Necrosis Factor-alpha | 2020 |
Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice.
Topics: Animals; Cytokines; Dermatitis; Female; Humans; Imiquimod; Inflammation; Intraepithelial Lymphocytes; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Psoriasis; Receptors, Interleukin-1; Skin | 2020 |
Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.
Topics: Animals; GTP-Binding Proteins; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Protein Glutamine gamma Glutamyltransferase 2; Psoriasis; Transglutaminases | 2020 |
Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide.
Topics: Animals; Autoimmune Diseases; Female; Gene Silencing; Imidazoles; Imiquimod; Interleukin-23 Subunit p19; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; Nylons; Psoriasis; Pyrroles; Uveitis | 2020 |
Development of flavanone and its derivatives as topical agents against psoriasis: The prediction of therapeutic efficiency through skin permeation evaluation and cell-based assay.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Female; Flavanones; Humans; Imiquimod; Keratinocytes; Mice; Models, Biological; Models, Molecular; Permeability; Psoriasis; Skin; Skin Absorption; Specific Pathogen-Free Organisms; Structure-Activity Relationship; Swine; Water Loss, Insensible | 2020 |
Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells.
Topics: Adenine; Animals; BALB 3T3 Cells; Dendritic Cells; Down-Regulation; Imiquimod; Inflammation Mediators; Male; Mice; Neutrophils; Oxidation-Reduction; Oxidative Stress; Peroxidase; Piperidines; Psoriasis; Signal Transduction; Skin | 2020 |
Albendazole negatively regulates keratinocyte proliferation.
Topics: Albendazole; Animals; cdc25 Phosphatases; Cell Line; Cell Proliferation; Cytokines; Dermatologic Agents; Disease Models, Animal; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Humans; Imiquimod; Inflammation Mediators; Keratinocytes; Keratins; Male; Mice, Inbred C57BL; Phosphorylation; Psoriasis; S Phase Cell Cycle Checkpoints; Signal Transduction; Skin | 2020 |
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Topics: A549 Cells; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; Female; HEK293 Cells; HeLa Cells; Humans; Imiquimod; Immunity, Innate; Inflammation Mediators; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred BALB C; Molecular Structure; Psoriasis; Signal Transduction; Structure-Activity Relationship; Transcription Factors; Ubiquitin-Protein Ligases; Ubiquitins | 2020 |
Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Arthritis, Experimental; Arthritis, Psoriatic; CD4-Positive T-Lymphocytes; Cell Differentiation; Collagen Type II; Disease Models, Animal; Imiquimod; Interleukin-17; Interleukin-2; Mannans; Membrane Proteins; Mice; Mice, Knockout; Psoriasis; Saccharomyces cerevisiae; Skin; T-Lymphocytes, Regulatory; Th17 Cells; Transforming Growth Factor beta | 2020 |
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Humans; Imiquimod; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; Phosphodiesterase 4 Inhibitors; Psoriasis; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction | 2020 |
Interleukin-33 alleviates psoriatic inflammation by suppressing the T helper type 17 immune response.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Humans; Imiquimod; Immune Tolerance; Immunity, Cellular; Inflammation; Interleukin-17; Interleukin-33; Mice; Mice, Inbred C57BL; Psoriasis; Skin; Th17 Cells | 2020 |
Differential Effects of Biologics on Psoriasis-Related Vascular Inflammation and Risk of Thrombosis.
Topics: Animals; Biological Products; Cell Communication; Endothelial Cells; Humans; Imiquimod; Leukocytes; Mice; Psoriasis; Thrombosis; Tumor Necrosis Factor-alpha; Vasculitis | 2020 |
Combination Therapy of Acarbose and Cyclosporine a Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice.
Topics: Acarbose; Animals; Anti-Inflammatory Agents; Cyclosporine; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Gene Expression Regulation; Humans; Imiquimod; Male; Mice; Psoriasis; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha | 2020 |
IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.
Topics: Administration, Cutaneous; Animals; Drug Eruptions; Female; Gene Deletion; Imiquimod; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Otitis Externa; Psoriasis; Receptors, Interleukin-1; Signal Transduction | 2020 |
Estrogen receptor α activation aggravates imiquimod-induced psoriasis-like dermatitis in mice by enhancing dendritic cell interleukin-23 secretion.
Topics: Animals; Dendritic Cells; Estrogen Receptor alpha; Humans; Imiquimod; Inflammation; Interleukin-23; Male; Mice; Models, Animal; Pruritus; Psoriasis | 2020 |
Heptapeptide HP3 acts as a potent inhibitor of experimental imiquimod‑induced murine psoriasis and impedes the trans‑endothelial migration of mononuclear cells.
Topics: Animals; Cell Line; Disease Models, Animal; Endothelial Cells; Female; Humans; Imiquimod; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Oligopeptides; Psoriasis; Transendothelial and Transepithelial Migration | 2020 |
Immune Modulation of Monocytes Dampens the IL-17
Topics: Animals; Antigens, Ly; Disease Models, Animal; Humans; Imiquimod; Immunologic Factors; Interleukin-17; Interleukin-1beta; Interleukin-23; Intraepithelial Lymphocytes; Macrophages; Male; Mice; Monocytes; Psoriasis; Severity of Illness Index; Skin | 2020 |
The Role of Gut Microbiome in Psoriasis: Oral Administration of
Topics: Administration, Oral; Animals; Animals, Genetically Modified; Cytokines; Disease Models, Animal; Feces; Female; Gastrointestinal Microbiome; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Mice; Psoriasis; RNA, Ribosomal, 16S; Staphylococcus aureus; Streptococcus; Tumor Necrosis Factor-alpha; Up-Regulation | 2020 |
Spleen and thymus metabolomics strategy to explore the immunoregulatory mechanism of total withanolides from the leaves of Datura metel L. on imiquimod-induced psoriatic skin dermatitis in mice.
Topics: Animals; Datura metel; Disease Models, Animal; Imiquimod; Immunosuppressive Agents; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Plant Extracts; Plant Leaves; Psoriasis; Spleen; Thymus Gland; Withanolides | 2020 |
Ozone Therapy Attenuates NF-κB-Mediated Local Inflammatory Response and Activation of Th17 Cells in Treatment for Psoriasis.
Topics: Administration, Topical; Animals; Baths; CD4-Positive T-Lymphocytes; Female; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; NF-kappa B; Oils; Ozone; Psoriasis; Severity of Illness Index; Th17 Cells; Toll-Like Receptor 2 | 2020 |
Stress aggravates and prolongs imiquimod-induced psoriasis-like epidermal hyperplasis and IL-1β/IL-23p40 production.
Topics: Animals; Anxiety; Dendritic Cells; Dermatitis; Emotions; Epidermis; Hyperplasia; Imiquimod; Inflammation; Interleukin-12 Subunit p40; Interleukin-1beta; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Nociceptors; Psoriasis; Receptors, Neurokinin-1; Stress, Psychological; Substance P; Up-Regulation | 2020 |
Local reinfusion of B10 cells is effective in the treatment of pustular psoriasis.
Topics: Autoimmune Diseases; Cell Differentiation; Humans; Imiquimod; Psoriasis; Skin | 2020 |
Regulatory T cells suppress skin inflammation in the imiquimod-induced psoriasis-like mouse model.
Topics: Animals; Dermatitis, Contact; Disease Models, Animal; Humans; Imiquimod; Interleukin-2 Receptor alpha Subunit; Intraepithelial Lymphocytes; Lymphocyte Depletion; Mice; Psoriasis; Severity of Illness Index; Skin; T-Lymphocytes, Regulatory; Time Factors | 2020 |
Notch-Hes1 Signaling Regulates IL-17A
Topics: Animals; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Imiquimod; Inflammation; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Psoriasis; Receptors, Notch; Signal Transduction; Skin; Spleen; T-Lymphocytes; Th17 Cells; Transcription Factor HES-1 | 2020 |
Exacerbated Imiquimod-Induced Psoriasis-Like Skin Inflammation in IRF5-Deficient Mice.
Topics: Animals; Cells, Cultured; Dendritic Cells; Female; Imiquimod; Interferon Inducers; Interferon Regulatory Factors; Interferons; Interleukins; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; Psoriasis; Skin; Th17 Cells | 2020 |
Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Psoriasis; Reverse Transcriptase Polymerase Chain Reaction | 2020 |
Design & development of nanosponge loaded topical gel of curcumin and caffeine mixture for augmented treatment of psoriasis.
Topics: Administration, Topical; Animals; beta-Cyclodextrins; Caffeine; Curcumin; Delayed-Action Preparations; Disease Models, Animal; Drug Combinations; Drug Compounding; Female; Formates; Imiquimod; Male; Mice; Nanostructures; Particle Size; Psoriasis | 2020 |
18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice.
Topics: Animals; Apoptosis; Cell Line; Cytokines; Female; Glycyrrhetinic Acid; Humans; Imiquimod; Keratinocytes; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Reactive Oxygen Species; Signal Transduction; Skin | 2020 |
Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chromones; Cytokines; Disease Models, Animal; HaCaT Cells; Humans; Imiquimod; Intercellular Adhesion Molecule-1; Keratinocytes; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Oxidative Stress; Phosphorylation; Psoriasis; Signal Transduction; Skin | 2020 |
Topical application of endothelin receptor a antagonist attenuates imiquimod-induced psoriasiform skin inflammation.
Topics: Administration, Topical; Animals; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression Regulation; Humans; Imiquimod; Mice; Phenylpropionates; Psoriasis; Pyridazines; Receptors, Endothelin; Skin | 2020 |
Complement component 3 prevents imiquimod-induced psoriatic skin inflammation by inhibiting apoptosis in mice.
Topics: Animals; Apoptosis; Complement C3; Cytokines; Female; Imiquimod; Inflammation; Interleukin-17; Male; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; T-Lymphocytes | 2020 |
2'-fucosyllactose inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response via the STAT3 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Female; Imiquimod; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Signal Transduction; Skin; STAT3 Transcription Factor; Th17 Cells; Trisaccharides | 2020 |
C5a/C5aR1 mediates IMQ-induced psoriasiform skin inflammation by promoting IL-17A production from γδ-T cells.
Topics: Animals; Cytokines; Down-Regulation; Female; Gene Expression; Imiquimod; Inflammation; Interleukin-17; Intraepithelial Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Receptor, Anaphylatoxin C5a; Signal Transduction; Skin | 2020 |
Therapeutic anti-psoriatic effects of myeloid-derived suppressor cells in combination with systemic tacrolimus (FK-506) in an imiquimod-induced mouse model of psoriasis.
Topics: Animals; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Female; Imiquimod; Immunomodulation; Immunosuppressive Agents; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Psoriasis; Skin; Spleen; T-Lymphocytes, Regulatory; Tacrolimus; Th1 Cells; Th17 Cells | 2020 |
Anti-psoriatic properties of paeoniflorin: suppression of the NF-kappaB pathway and Keratin 17.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cytokines; Down-Regulation; Female; Glucosides; HaCaT Cells; Humans; Imiquimod; Keratin-17; Keratinocytes; Keratins; Mice; Monoterpenes; NF-kappa B; Psoriasis; Signal Transduction | 2020 |
Chronic Alcohol Consumption Exacerbates the Severity of Psoriasiform Dermatitis in Mice.
Topics: Alcohol Drinking; Animals; Central Nervous System Depressants; Chemokine CCL20; Ethanol; Gene Expression Profiling; Imiquimod; Interferon Inducers; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Keratinocytes; Mice; Psoriasis; Skin; Th17 Cells | 2020 |
310 nm UV-LEDs attenuate imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice and inhibit IL-22-induced STAT3 expression in HaCaT cells.
Topics: Animals; Antineoplastic Agents; HaCaT Cells; Humans; Imiquimod; Inflammation; Interleukin-22; Interleukins; Mice; Mice, Inbred C57BL; Psoriasis; Skin; STAT3 Transcription Factor; Ultraviolet Rays | 2020 |
An Anti-Inflammatory Poly(PhosphorHydrazone) Dendrimer Capped with AzaBisPhosphonate Groups to Treat Psoriasis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Dendrimers; Diphosphonates; Disease Models, Animal; Hydrazones; Imiquimod; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Polymers; Psoriasis | 2020 |
Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome.
Topics: Animals; Cell Proliferation; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Prediabetic State; Psoriasis; Skin | 2020 |
Co-Delivery of Imiquimod and Curcumin by Nanoemugel for Improved Topical Delivery and Reduced Psoriasis-Like Skin Lesions.
Topics: Administration, Topical; Animals; Curcumin; Disease Models, Animal; Drug Combinations; Drug Compounding; Emulsions; Imiquimod; Male; Mice; Mice, Inbred BALB C; Nanogels; Oleic Acid; Particle Size; Permeability; Polyethylene Glycols; Polyethyleneimine; Polysorbates; Psoriasis; Rats | 2020 |
Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes.
Topics: Administration, Cutaneous; Animals; Disease Models, Animal; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Male; MAP Kinase Signaling System; Mice; NF-kappa B; Phosphorylation; Psoriasis; Skin; Thalidomide; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2020 |
Anti-psoriatic effect of Lavandula angustifolia essential oil and its major components linalool and linalyl acetate.
Topics: Acyclic Monoterpenes; Administration, Cutaneous; Animals; Cytokines; Dermatologic Agents; Disease Models, Animal; Female; Imiquimod; Inflammation Mediators; Lavandula; Mice, Inbred BALB C; Monoterpenes; Oils, Volatile; Plant Oils; Psoriasis; Rabbits; Signal Transduction; Skin | 2020 |
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
Topics: Acetylation; Animals; Disease Models, Animal; Down-Regulation; Humans; Imiquimod; Male; Mice; Mice, Knockout; Phosphorylation; Psoriasis; Pyruvate Kinase; Sirtuin 2; Skin; STAT3 Transcription Factor; Th17 Cells | 2021 |
Hispidulin alleviates imiquimod-induced psoriasis-like skin inflammation by inhibiting splenic Th1/Th17 cell population and keratinocyte activation.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Female; Flavones; Humans; Imiquimod; Keratinocytes; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Neutrophils; NF-kappa B; Psoriasis; Spleen; Th1 Cells; Th17 Cells | 2020 |
Delivery and Anti-Psoriatic Effect of Silibinin-Loaded Polymeric Micelles: An Experimental Study in the Psoriatic Skin Model.
Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Liberation; Female; Humans; Imiquimod; Mice; Micelles; Nanoparticles; Particle Size; Polymers; Psoriasis; Signal Transduction; Silybin; Skin; Skin Absorption; STAT3 Transcription Factor | 2020 |
Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model.
Topics: Animals; CCAAT-Enhancer-Binding Protein-delta; Cell Proliferation; Disease Models, Animal; Down-Regulation; HaCaT Cells; Humans; Imiquimod; Interleukin-17; Interleukin-6; Mice; Naphthoquinones; Psoriasis; Signal Transduction; STAT3 Transcription Factor | 2020 |
Uncovering the mechanism of Jueyin granules in the treatment of psoriasis using network pharmacology.
Topics: Animals; Cell Proliferation; Drugs, Chinese Herbal; Imiquimod; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Psoriasis; Treatment Outcome | 2020 |
Topics: Animals; Cytokines; Dermatitis; Female; Gene Expression Regulation; Imiquimod; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-17; Interleukin-23 Subunit p19; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Tumor Necrosis Factor-alpha | 2020 |
Methotrexate-Loaded Nanostructured Lipid Carrier Gel Alleviates Imiquimod-Induced Psoriasis by Moderating Inflammation: Formulation, Optimization, Characterization, In-Vitro and In-Vivo Studies.
Topics: Administration, Cutaneous; Administration, Topical; Animals; Catalase; Cytokines; Drug Carriers; Drug Compounding; Drug Liberation; Gels; Glutathione; Humans; Imiquimod; Inflammation; Lipids; Malondialdehyde; Methotrexate; Mice, Inbred BALB C; Nanostructures; Organ Size; Psoriasis; Superoxide Dismutase | 2020 |
A Localized Aldara (5% Imiquimod)-Induced Psoriasiform Dermatitis Model in Mice Using Finn Chambers.
Topics: Animals; Dermatitis; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred C57BL; Psoriasis; Skin | 2020 |
Role of keratinocytes and immune cells in the anti-inflammatory effects of Tripterygium wilfordii Hook. f. in a murine model of psoriasis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Proliferation; Cytokines; Dermatologic Agents; Disease Models, Animal; Drugs, Chinese Herbal; Imiquimod; Keratinocytes; Male; Mice, Inbred BALB C; Plant Roots; Psoriasis; T-Lymphocytes, Regulatory; Tripterygium | 2020 |
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Chaperonin 60; Disease Models, Animal; Down-Regulation; HaCaT Cells; HSP90 Heat-Shock Proteins; Humans; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Protein Binding; Pruritus; Psoriasis; Quinolizines | 2020 |
Multi-component clobetasol-loaded monolithic lipid-polymer hybrid nanoparticles ameliorate imiquimod-induced psoriasis-like skin inflammation in Swiss albino mice.
Topics: Animals; Clobetasol; Imiquimod; Inflammation; Lipids; Mice; Nanoparticles; Polymers; Psoriasis | 2020 |
An Autocrine Circuit of IL-33 in Keratinocytes Is Involved in the Progression of Psoriasis.
Topics: Adult; Animals; Autocrine Communication; Biopsy; Case-Control Studies; Disease Models, Animal; Disease Progression; Healthy Volunteers; Humans; Imiquimod; Injections, Intradermal; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Keratinocytes; Male; Mice; Middle Aged; Psoriasis; Recombinant Proteins; Severity of Illness Index; Signal Transduction; Skin; Transcriptional Activation; Up-Regulation | 2021 |
Neutrophils Enhance Cutaneous Vascular Dilation and Permeability to Aggravate Psoriasis by Releasing Matrix Metallopeptidase 9.
Topics: Animals; Biopsy; Capillary Permeability; Cell Line; Chemotaxis; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Female; Imiquimod; Interleukin-23; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Neutrophil Infiltration; Neutrophils; Primary Cell Culture; Psoriasis; Recombinant Proteins; Skin; Transendothelial and Transepithelial Migration; Vasodilation | 2021 |
A monocyte-keratinocyte-derived co-culture assay accurately identifies efficacies of BET inhibitors as therapeutic candidates for psoriasiform dermatitis.
Topics: Acetanilides; Administration, Oral; Animals; Cell Line, Tumor; Coculture Techniques; Disease Models, Animal; Drug Evaluation, Preclinical; Epigenesis, Genetic; Female; HaCaT Cells; Heterocyclic Compounds, 3-Ring; Humans; Imiquimod; Inflammation Mediators; Mice; Monocytes; Psoriasis; Pyridones; Skin; Sulfonamides | 2020 |
The Protective Effects of 18
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Glycyrrhetinic Acid; Imiquimod; Immunohistochemistry; Inflammation Mediators; Mice; Protective Agents; Psoriasis; Signal Transduction; STAT3 Transcription Factor; T-Lymphocyte Subsets; TOR Serine-Threonine Kinases | 2020 |
Luteolin attenuates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Female; Imiquimod; Luteolin; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Psoriasis; RAW 264.7 Cells | 2020 |
Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8
Topics: Animals; Artemisinins; CD8-Positive T-Lymphocytes; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Imiquimod; Immunologic Memory; Interleukin-15; Interleukin-17; Male; Methotrexate; Mice; Psoriasis; Recurrence; Secondary Prevention; Skin; Skin Transplantation; Transplantation Chimera | 2020 |
Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir
Topics: Animals; Dendritic Cells; Disease Models, Animal; Female; Fibroblasts; Humans; Imiquimod; Macrophages; Membrane Proteins; Mice; Mice, Knockout; Psoriasis; RNA-Seq; Single-Cell Analysis; Skin; Transcription, Genetic; Transcriptome | 2020 |
Thymol activates TRPM8-mediated Ca
Topics: Animals; Antipruritics; Behavior, Animal; Calcium; Cell Differentiation; Cytokines; Imiquimod; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurons; Pruritus; Psoriasis; Skin; Thymol; TRPM Cation Channels | 2020 |
Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis.
Topics: Animals; Cell Lineage; Disease Models, Animal; Epidermis; Gene Expression Regulation; Granzymes; Humans; Imiquimod; Immunologic Memory; Integrin alpha1; Mice; Psoriasis; T-Lymphocytes | 2020 |
IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cells, Cultured; Disease Models, Animal; Gene Knock-In Techniques; Half-Life; Histocompatibility Antigens Class I; Imiquimod; Interleukin-17; Interleukin-23; Interleukin-23 Subunit p19; Leukocytes, Mononuclear; Macaca fascicularis; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phosphorylation; Psoriasis; Receptors, Fc; Signal Transduction; Skin; STAT3 Transcription Factor | 2020 |
Evaluating the effect of rice (Oryza sativa L.: SRNC05053-6-2) crude extract on psoriasis using in vitro and in vivo models.
Topics: Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Epidermis; Filaggrin Proteins; Humans; Imiquimod; Oryza; Plant Extracts; Psoriasis; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein A7; Skin; Skin, Artificial; Treatment Outcome | 2020 |
Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Cell Proliferation; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Rabbits; Umbelliferones | 2020 |
Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis.
Topics: Animals; Disease Models, Animal; Histamine; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2020 |
DGT, a novel heterocyclic diterpenoid, effectively suppresses psoriasis via inhibition of STAT3 phosphorylation.
Topics: Animals; Disease Models, Animal; Diterpenes; Female; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Phosphorylation; Psoriasis; Skin | 2021 |
4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates imiquimod-induced psoriasis-like dermatitis and inhibits inflammatory cytokines production by suppressing the NF-κB and MAPK signaling pathways.
Topics: Animals; Chromones; Cytokines; Dermatitis; Glucosides; Imiquimod; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis | 2020 |
A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; Enzyme Inhibitors; Humans; Imiquimod; In Vitro Techniques; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Psoriasis; RNA, Messenger; Skin; Th17 Cells | 2020 |
Curcuma's extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin, proliferating cell nuclear antigen and toll-like receptor expression.
Topics: Animals; Curcuma; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Female; Guinea Pigs; Imiquimod; Keratins; Male; Mice; Mitosis; Plant Extracts; Proliferating Cell Nuclear Antigen; Propranolol; Psoriasis; Rhizome; Skin; Time Factors; Toll-Like Receptors; Vagina | 2020 |
TLR2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation through Decrease in Regulatory T Cells and Impaired IL-10 Production.
Topics: Animals; Imiquimod; Inflammation; Interleukin-10; Mice; Mice, Knockout; Psoriasis; Skin; T-Lymphocytes, Regulatory; Toll-Like Receptor 2 | 2020 |
Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice.
Topics: Administration, Topical; Animals; Cells, Cultured; Chemokines; Cytokines; Disease Models, Animal; Extracellular Traps; Imiquimod; Interleukin-1; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Mice, Mutant Strains; Neutrophils; Ornithine; Psoriasis | 2020 |
Small interfering RNA targeting of keratin 17 reduces inflammation in imiquimod-induced psoriasis-like dermatitis.
Topics: Animals; Dermatitis; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Keratin-17; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Small Interfering; Skin | 2020 |
IL-37 Expression Is Downregulated in Lesional Psoriasis Skin.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Female; Humans; Imiquimod; Inflammation; Interleukin-1; Interleukin-17; Keratinocytes; Mice; Mice, Inbred C57BL; Psoriasis; Tumor Necrosis Factor-alpha | 2020 |
Depressive-like behaviors in mice with Imiquimod-induced psoriasis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Cytokines; Depression; Disease Models, Animal; Epinephrine; Exploratory Behavior; Fluoxetine; Food Preferences; gamma-Aminobutyric Acid; Imiquimod; Male; Mice, Inbred BALB C; Neurotransmitter Agents; Norepinephrine; Open Field Test; Psoriasis; Serotonin; Skin | 2020 |
Chemical profiling and anti-psoriatic activity of marine sponge (Dysidea avara) in induced imiquimod-psoriasis-skin model.
Topics: Animals; Anti-Inflammatory Agents; Biological Products; Disease Models, Animal; Drug Evaluation, Preclinical; Dysidea; Female; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Mice; Psoriasis; Severity of Illness Index; Skin; Tumor Necrosis Factor-alpha | 2020 |
OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia.
Topics: Animals; Cell Differentiation; Cell Proliferation; Disease Models, Animal; DNA-Binding Proteins; Epidermis; Female; Humans; Hyperplasia; Imiquimod; Interleukin-1alpha; Male; Mice, Knockout; Psoriasis; RNA-Seq; Signal Transduction; Single-Cell Analysis; Transcription Factors; Up-Regulation | 2021 |
ALK3 Is Not Required for the Embryonic Development, Homeostasis, and Repopulation of Epidermal Langerhans Cells in Steady and Inflammatory States.
Topics: Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Disease Models, Animal; Embryo, Mammalian; Embryonic Development; Homeostasis; Humans; Imiquimod; Langerhans Cells; Mice; Mice, Knockout; Psoriasis; Severity of Illness Index; Signal Transduction | 2021 |
Deletion of
Topics: Animals; Antibodies, Blocking; Calgranulin A; Calgranulin B; Cells, Cultured; Disease Models, Animal; Humans; Hyperplasia; Imiquimod; Interleukin-17; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Th17 Cells | 2021 |
Protocol for Flow Cytometric Detection of Immune Cell Infiltration in the Epidermis and Dermis of a Psoriasis Mouse Model.
Topics: Aminoquinolines; Animals; Cytokines; Dermis; Disease Models, Animal; Epidermal Cells; Epidermis; Flow Cytometry; Imiquimod; Inflammation; Leukemic Infiltration; Mice; Psoriasis; Skin | 2020 |
Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation.
Topics: Administration, Topical; Animals; Biomarkers; Biopsy; Disease Models, Animal; Exosomes; Imiquimod; Mesenchymal Stem Cells; Mice; Permeability; Phenotype; Psoriasis; Skin; Skin Absorption | 2021 |
Topical Application of BMS-509744, a Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase, Ameliorates Imiquimod-Induced Skin Inflammation in Mice.
Topics: Animals; CD3 Complex; Dermatitis; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Protein-Tyrosine Kinases; Psoriasis; Skin; Th17 Cells; Tumor Necrosis Factor-alpha | 2021 |
Short-Term Western Diet Intake Promotes IL-23‒Mediated Skin and Joint Inflammation Accompanied by Changes to the Gut Microbiota in Mice.
Topics: Animals; Arthritis, Psoriatic; Diet, Western; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Humans; Imiquimod; Interleukin-23; Mice; Psoriasis; Signal Transduction | 2021 |
Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
Topics: Acyltransferases; Animals; Cell Line; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Interferon-alpha; Lymphocyte Activation; Male; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Signal Transduction; Skin; T-Lymphocytes; Tumor Suppressor Proteins; Up-Regulation | 2020 |
Application of imiquimod-induced murine psoriasis model in evaluating interleukin-17A antagonist.
Topics: Animals; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Imiquimod; Interleukin-17; Mice; Mice, Inbred C57BL; Psoriasis; Signal Transduction | 2021 |
Pentacyclic triterpene compounds from loquat leaves reduce skin inflammation and epidermal hyperplasia in psoriasis via inhibiting the Th17 cells.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Disease Models, Animal; Epidermis; Eriobotrya; Humans; Hyperplasia; Imiquimod; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Pentacyclic Triterpenes; Plant Leaves; Psoriasis; Th17 Cells | 2021 |
Strain specific response of mice to IMQ-induced psoriasis.
Topics: Animals; Imiquimod; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Psoriasis | 2021 |
Skin-Homing Regulatory B Cells Required for Suppression of Cutaneous Inflammation.
Topics: Animals; B-Lymphocytes, Regulatory; Cell Movement; Dermatitis; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-10; Male; Mice; Psoriasis; Skin | 2021 |
Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Correlation of Data; Cytokines; Gastrointestinal Microbiome; Imiquimod; Inflammation; Male; Medicine, Chinese Traditional; Mice, Inbred BALB C; Psoriasis; RNA, Ribosomal, 16S; T-Lymphocytes, Regulatory; Th17 Cells | 2021 |
JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara
Topics: Animals; Cytokines; Disease Models, Animal; Epigenome; ErbB Receptors; Female; Imiquimod; Inflammation Mediators; Keratinocytes; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Myeloid Cells; Psoriasis; Signal Transduction; Skin; Transcriptome | 2020 |
Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation.
Topics: Animals; Antigens, CD1; Cell Line; Disease Models, Animal; Gene Expression Regulation; Group IV Phospholipases A2; Humans; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Male; Mice, Inbred BALB C; Psoriasis; RNA, Small Interfering | 2021 |
The Skin-Liver Axis Modulates the Psoriasiform Phenotype and Involves Leucine-Rich α-2 Glycoprotein.
Topics: Animals; Biomarkers; Cytokines; Disease Models, Animal; Glycoproteins; Humans; Imiquimod; Inflammation Mediators; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Up-Regulation | 2021 |
CCR4 Involvement in the Expansion of T Helper Type 17 Cells in a Mouse Model of Psoriasis.
Topics: Animals; Cell Communication; Cell Proliferation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Transgenic; Primary Cell Culture; Psoriasis; Receptors, CCR4; Skin; Th17 Cells | 2021 |
The nerve injuries attenuate the persistence of psoriatic lesions.
Topics: Adult; Aged; Aged, 80 and over; Animals; Denervation; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Imiquimod; Male; Mice; Middle Aged; Neuroimmunomodulation; Peripheral Nerve Injuries; Psoriasis; Retrospective Studies; Skin | 2021 |
MTH1 Inhibitors for the Treatment of Psoriasis.
Topics: Administration, Cutaneous; Animals; Apoptosis; Biopsy; Cell Line, Tumor; Disease Models, Animal; DNA Repair Enzymes; Female; Humans; Imiquimod; Keratinocytes; Mice; Oxidative Stress; Phosphoric Monoester Hydrolases; Primary Cell Culture; Psoriasis; Skin | 2021 |
Qinzhuliangxue mixture alleviates psoriasis-like skin lesions via inhibiting the IL6/STAT3 axis.
Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Cytokines; Drugs, Chinese Herbal; Hypoxia-Inducible Factor 1, alpha Subunit; Imiquimod; Keratinocytes; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Phytochemicals; Protein Interaction Maps; Psoriasis; Skin; STAT3 Transcription Factor | 2021 |
miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Imiquimod; Janus Kinase 3; Keratinocytes; Lipocalin-2; Male; MicroRNAs; Psoriasis; Rats; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor | 2021 |
Selenium nanoparticles produce a beneficial effect in psoriasis by reducing epidermal hyperproliferation and inflammation.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line; Glycogen Synthase Kinase 3 beta; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Nanoparticles; Oxidation-Reduction; Phosphorylation; Psoriasis; Reactive Oxygen Species; Selenium; STAT3 Transcription Factor | 2021 |
Green Phellodendri Chinensis Cortex-based carbon dots for ameliorating imiquimod-induced psoriasis-like inflammation in mice.
Topics: Animals; Carbon; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Psoriasis; RAW 264.7 Cells; Skin | 2021 |
Fingolimod ameliorates imiquimod-induced psoriasiform dermatitis by sequestrating interleukin-17-producing ?d T cells in secondary lymph nodes.
Topics: Animals; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Female; Fingolimod Hydrochloride; Humans; Imiquimod; Interleukin-17; Intraepithelial Lymphocytes; Langerhans Cells; Lymph Nodes; Mice; Psoriasis; Skin; Up-Regulation | 2021 |
Improved imiquimod-induced psoriasis like dermatitis using microneedles in mice.
Topics: Administration, Cutaneous; Animals; Cytokines; Dermatitis; Disease Models, Animal; Drug Delivery Systems; Female; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Needles; Pharmaceutical Preparations; Polyesters; Polymers; Psoriasis; Skin; Swine | 2021 |
Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis.
Topics: Administration, Topical; Animals; Benzimidazoles; Binding Sites; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Stability; Humans; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Skin | 2021 |
Rapamycin Alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Aggravated Dermatitis in Mice with Imiquimod-Induced Psoriasis-Like Dermatitis by Inducing Autophagy.
Topics: Animals; Autophagy; Cell Differentiation; Cells, Cultured; Cytochrome P-450 CYP1A1; Dermatitis; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; NADPH Oxidase 4; NF-E2-Related Factor 2; Polychlorinated Dibenzodioxins; Psoriasis; Receptors, Aryl Hydrocarbon; Sirolimus | 2021 |
Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo.
Topics: Adult; Animals; Cell Line; Cells, Cultured; Female; HEK293 Cells; Humans; Imiquimod; Inflammation; Male; Mice; Mice, Inbred BALB C; Neutrophils; Psoriasis; Receptors, Formyl Peptide; Triterpenes; Ursolic Acid; Young Adult | 2021 |
2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice.
Topics: Animals; Biomarkers; Cell Survival; Cinnamates; Cytokines; Disease Management; Disease Models, Animal; Disease Susceptibility; Imiquimod; Mice; Psoriasis; Pyruvate Kinase; Signal Transduction; STAT3 Transcription Factor; T-Lymphocyte Subsets; Th17 Cells | 2021 |
A Targetable, Noncanonical Signal Transducer and Activator of Transcription 3 Activation Induced by the Y-Less Region of IL-22 Receptor Orchestrates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice.
Topics: Animals; Citrobacter rodentium; Enterobacteriaceae Infections; Imiquimod; Interleukin-22; Interleukins; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, Interleukin; STAT3 Transcription Factor | 2021 |
Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4.
Topics: Animals; Case-Control Studies; CD3 Complex; Chemotaxis, Leukocyte; Desmogleins; Disease Models, Animal; Down-Regulation; Female; Humans; Imiquimod; Inflammation Mediators; Psoriasis; Rats, Sprague-Dawley; Rats, Transgenic; Skin; T-Lymphocytes | 2021 |
Rosmarinic acid protects mice from imiquimod induced psoriasis-like skin lesions by inhibiting the IL-23/Th17 axis via regulating Jak2/Stat3 signaling pathway.
Topics: Animals; Cinnamates; Cytokines; Depsides; Disease Models, Animal; HaCaT Cells; Humans; Imiquimod; Interleukin-23; Janus Kinase 2; Mice; Mice, Inbred BALB C; Psoriasis; Rosmarinic Acid; Signal Transduction; Skin; STAT3 Transcription Factor; Th17 Cells | 2021 |
Supplemental Leuconostoc mesenteroides strain NTM048 attenuates imiquimod-induced psoriasis in mice.
Topics: Animals; Disease Models, Animal; Imiquimod; Leuconostoc mesenteroides; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2021 |
Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.
Topics: Adult; Animals; Anti-Inflammatory Agents; Carbazoles; Disease Models, Animal; Female; Glycyrrhiza; Glycyrrhizic Acid; HaCaT Cells; Humans; Imiquimod; Interleukin-17; Mice; Psoriasis; RNA, Small Interfering; Sirtuin 1; Skin; STAT3 Transcription Factor | 2021 |
Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice.
Topics: Animals; Dermatitis; Disease Models, Animal; Female; Gastrointestinal Microbiome; Imiquimod; Lactic Acid; Mice; Mice, Inbred C57BL; Microbiota; Psoriasis; Skin; Staphylococcus; Succinic Acid | 2021 |
Molecular and histopathological profiling of imiquimod induced dermatosis in Swiss Wistar rats: contribution to the rat model for novel anti-psoriasis treatments.
Topics: Administration, Cutaneous; Animals; Betamethasone; Cytokines; Disease Models, Animal; Down-Regulation; Imiquimod; Male; Ointments; Psoriasis; Rats; Rats, Wistar; Severity of Illness Index; Signal Transduction; Skin; Transcriptome; Treatment Outcome; Up-Regulation | 2021 |
Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation.
Topics: Animals; Cell Cycle; Cell Proliferation; Constitutive Androstane Receptor; Cytokines; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Ki-67 Antigen; Mice; Psoriasis | 2021 |
Tacrolimus-loaded chitosan nanoparticles for enhanced skin deposition and management of plaque psoriasis.
Topics: Administration, Cutaneous; Animals; Chitosan; Drug Carriers; Drug Liberation; Ear; Imiquimod; Immunosuppressive Agents; Mice, Inbred C57BL; Nanoparticles; Particle Size; Psoriasis; Rats, Sprague-Dawley; Skin; Tacrolimus | 2021 |
Protectin D1 reduces imiquimod-induced psoriasiform skin inflammation.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Docosahexaenoic Acids; Female; HaCaT Cells; Humans; Imiquimod; Injections, Subcutaneous; Keratinocytes; Mice; Phosphorylation; Psoriasis; Signal Transduction; Skin; Spleen; STAT1 Transcription Factor; Th1 Cells; Th17 Cells | 2021 |
Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Cytokines; Dermatitis; Disease Models, Animal; Down-Regulation; Flavonoids; Heme Oxygenase-1; Imiquimod; Male; Membrane Proteins; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Peroxidase; Psoriasis; Signal Transduction; Spleen | 2021 |
Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy.
Topics: Administration, Topical; Animals; Imiquimod; Methotrexate; Mice; Mice, Inbred BALB C; Niacinamide; Psoriasis; Skin | 2021 |
Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis.
Topics: Animals; Cell Line; Cell Proliferation; Disease Models, Animal; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Matrix Metalloproteinase 13; Mice; Nicotinic Acids; Psoriasis; Retinoids; Ultraviolet Rays; Ultraviolet Therapy | 2021 |
Impact of barrier tissue inflammation and physical activity on joint homeostasis in mice.
Topics: Animals; Disease Models, Animal; Homeostasis; Humans; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Psoriasis | 2022 |
The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Chemokine CCL2; Cytokines; Dendritic Cells; Dermatitis; Endoribonucleases; Epigenomics; Humans; Imiquimod; Inflammation; Interleukin-6; Macrophages; Mice; Mice, Knockout; Myeloid Cells; Psoriasis; Ribonucleases; Skin; Tumor Necrosis Factor-alpha | 2021 |
Taxifolin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like mouse model via regulating cytoplasmic phospholipase A2 and PPAR-γ pathway.
Topics: Animals; Cell Line; Cell Proliferation; Cytoplasm; Disease Models, Animal; Down-Regulation; Humans; Imiquimod; Keratinocytes; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phospholipases A2; Phosphorylation; PPAR gamma; Proteomics; Psoriasis; Quercetin; Signal Transduction | 2021 |
Tuhuaiyin alleviates imiquimod-induced psoriasis via inhibiting the properties of IL-17-producing cells and remodels the gut microbiota.
Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Humans; Imiquimod; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Network Pharmacology; Psoriasis | 2021 |
Transient Induction of Fever in the Imiquimod C57BL/6 Mouse Model of Psoriasis-Like Disease Involves IL-1 and IL-6 but Not IL-36.
Topics: Animals; Disease Models, Animal; Fever; Humans; Imiquimod; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin | 2022 |
Inhibition of CtBP-Regulated Proinflammatory Gene Transcription Attenuates Psoriatic Skin Inflammation.
Topics: Alcohol Oxidoreductases; Animals; Anti-Inflammatory Agents; Cell Proliferation; Disease Models, Animal; DNA-Binding Proteins; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Mice; Mice, Transgenic; Psoriasis; Transcriptional Activation | 2022 |
Differential Involvement of Programmed Cell Death Ligands in Skin Immune Responses.
Topics: Animals; Antigen Presentation; B7-H1 Antigen; Calcitriol; Cells, Cultured; Cytokines; Dendritic Cells; Dermatitis, Atopic; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Humans; Imiquimod; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Ligand 2 Protein; Psoriasis; Skin; Th1 Cells; Th17 Cells; Th2 Cells | 2022 |
Capsaicin attenuates imiquimod-induced epidermal hyperplasia and cutaneous inflammation in a murine model of psoriasis.
Topics: Administration, Topical; Animals; Antineoplastic Agents; Antipruritics; Capsaicin; Dermatitis; Disease Models, Animal; Epidermis; Female; Hyperplasia; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2021 |
Modular pharmacology-based approach to identify hub genes and kernel pathways of taodan granules treated psoriasis.
Topics: Algorithms; Animals; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; HaCaT Cells; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Network Pharmacology; Psoriasis; RNA, Messenger; Signal Transduction; Up-Regulation | 2021 |
IFN-κ Is a Rheostat for Development of Psoriasiform Inflammation.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Interferon Type I; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Up-Regulation | 2022 |
Curcumin alleviates imiquimod-induced psoriasis in progranulin-knockout mice.
Topics: Animals; Cell Proliferation; Curcumin; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Keratinocytes; Male; Mice; Mice, Knockout; Progranulins; Psoriasis | 2021 |
TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.
Topics: Animals; Imiquimod; Mice; Nanoparticles; Psoriasis; RNA, Small Interfering; Tumor Necrosis Factor-alpha | 2021 |
Glycerol Improves Skin Lesion Development in the Imiquimod Mouse Model of Psoriasis: Experimental Confirmation of Anecdotal Reports from Patients with Psoriasis.
Topics: Animals; Aquaporin 3; Disease Models, Animal; Glycerol; Humans; Imiquimod; Mice; Mice, Knockout; Phospholipase D; Psoriasis; Skin | 2021 |
Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice by inhibiting the maturation and activation of dendritic cells.
Topics: Acetophenones; Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Cytokines; Dendritic Cells; Disease Models, Animal; Imiquimod; Inflammation Mediators; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Myeloid Differentiation Factor 88; Psoriasis; Skin; Toll-Like Receptor 8 | 2017 |
Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.
Topics: Adult; Aged; Aminoquinolines; Animals; Antibodies, Blocking; Cells, Cultured; Female; Gene Knockout Techniques; Humans; Imiquimod; Inflammation; Interleukin-22; Interleukins; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Middle Aged; Psoriasis; Rats; Rats, Sprague-Dawley; Receptors, Interleukin; Signal Transduction; Skin; Young Adult | 2017 |
CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells.
Topics: Aminoquinolines; Animals; Chemokine CCL4; Chemokine CCL5; Chemokines; Chemokines, CXC; Chemotaxis; Cytokines; Dermatitis; Epidermis; Humans; Imiquimod; Keratinocytes; Mice; Myeloid-Derived Suppressor Cells; Psoriasis; Skin; T-Lymphocytes, Regulatory | 2017 |
PAMs ameliorates the imiquimod-induced psoriasis-like skin disease in mice by inhibition of translocation of NF-κB and production of inflammatory cytokines.
Topics: Active Transport, Cell Nucleus; Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Female; Humans; Imiquimod; Interferon-gamma; Mice, Inbred BALB C; NF-kappa B; Phytotherapy; Psoriasis; Skin | 2017 |
Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Catalase; Cytokines; Glutathione; Imiquimod; Male; Malondialdehyde; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Quercetin; Signal Transduction; Skin; Superoxide Dismutase | 2017 |
Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice.
Topics: Aminoquinolines; Animals; Behavior, Animal; Disease Models, Animal; Drug Eruptions; Imiquimod; Male; Mice, Inbred C57BL; Narcotic Antagonists; Psoriasis; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Skin; Spinal Cord | 2017 |
IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression.
Topics: Aminoquinolines; Animals; Brain; Depression; Depressive Disorder, Major; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-17; MAP Kinase Signaling System; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Psoriasis | 2017 |
Imiquimod induced ApoE-deficient mice might be a composite animal model for the study of psoriasis and dyslipideamia comorbidity.
Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aminoquinolines; Animals; Back; Cell Proliferation; Cholesterol; Comorbidity; Disease Models, Animal; Dyslipidemias; Imiquimod; Interleukin-17; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Psoriasis; Signal Transduction; Skin; STAT3 Transcription Factor | 2017 |
Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice.
Topics: Administration, Topical; Aminoquinolines; Animals; Caspase 14; Dendritic Cells; Disease Models, Animal; Imiquimod; Immunosuppressive Agents; Keratin-10; Keratin-14; Ki-67 Antigen; Langerhans Cells; Lymph Nodes; Macrophages; Membrane Proteins; Mice, Inbred BALB C; Neovascularization, Physiologic; Protein Precursors; Psoriasis; Sirolimus; Skin; TOR Serine-Threonine Kinases | 2017 |
The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cell Line; Female; Humans; Imiquimod; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Purinergic P2X7 | 2017 |
Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation.
Topics: Aminoquinolines; Animals; Asymmetric Cell Division; Carcinoma, Squamous Cell; Cell Proliferation; Homeostasis; Humans; Imiquimod; Interleukin-17; Mice; Psoriasis | 2017 |
Cyr61/CCN1 induces CCL20 production by keratinocyte via activating p38 and JNK/AP-1 pathway in psoriasis.
Topics: Aminoquinolines; Animals; Biopsy; Chemokine CCL20; Cysteine-Rich Protein 61; Disease Models, Animal; Epidermis; Female; Gene Knockdown Techniques; Humans; Imiquimod; Interleukin-23; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Lymphocyte Activation; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Promoter Regions, Genetic; Psoriasis; RNA Interference; RNA, Small Interfering; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Up-Regulation | 2017 |
Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Immunity, Innate; Interleukin-1beta; Interleukin-23; Mice; Mice, Knockout; Myeloid Cells; Myeloid Differentiation Factor 88; Psoriasis; Skin | 2017 |
Drug Repurposing by Simulating Flow Through Protein-Protein Interaction Networks.
Topics: Algorithms; Animals; Cell Line; Computer Simulation; Dermatitis; Drug Evaluation, Preclinical; Drug Repositioning; Ear, External; Gene Regulatory Networks; Humans; Imiquimod; Machine Learning; Mice; Mice, Inbred BALB C; NF-kappa B; Protein Interaction Domains and Motifs; Protein Interaction Maps; Psoriasis; RNA; Support Vector Machine; Tumor Necrosis Factor-alpha | 2018 |
Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Glycosides; Humans; Imiquimod; Keratinocytes; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NF-kappa B; Phenols; Primary Cell Culture; Psoriasis; Rhododendron; RNA, Messenger; Skin; Toll-Like Receptor 7 | 2017 |
Imiquimod-applied Interleukin-10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state.
Topics: Adjuvants, Immunologic; Animals; Body Weight; Cytokines; Dermatitis; Disease Models, Animal; Epidermis; Imiquimod; Inflammation; Interleukin-10; Interleukin-17; Keratinocytes; Leukocyte Common Antigens; Male; Mice; Mice, Inbred C57BL; Organ Size; Psoriasis; RNA, Messenger; Skin; Spleen; Time Factors | 2018 |
Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis.
Topics: Adult; Aged; Aminoquinolines; Animals; Cells, Cultured; Chemokine CCL20; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-17; Keratinocytes; Liver; Male; Mice; Mice, Inbred C57BL; Middle Aged; Psoriasis; Receptors, CCR6; Recombinant Proteins; Serum Amyloid A Protein; Skin; Th17 Cells; Up-Regulation | 2017 |
Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin.
Topics: Aminoquinolines; Biomarkers; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Curcumin; Cytokines; Drug Evaluation, Preclinical; Filaggrin Proteins; Humans; Imiquimod; Keratinocytes; Molecular Docking Simulation; Protein Conformation; Psoriasis; Skin | 2017 |
GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency.
Topics: Aminoquinolines; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imiquimod; Interferon Inducers; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis | 2017 |
Role of neurturin in spontaneous itch and increased nonpeptidergic intraepidermal fiber density in a mouse model of psoriasis.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antibodies; Calcitonin Gene-Related Peptide; Disease Models, Animal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Imiquimod; Male; Mice; Mice, Inbred C57BL; Nerve Fibers; Neurturin; Pruritus; Psoriasis; Receptors, Purinergic P2X3; RNA, Messenger; Skin | 2017 |
Lack of Galanin Receptor 3 Alleviates Psoriasis by Altering Vascularization, Immune Cell Infiltration, and Cytokine Expression.
Topics: Adult; Animals; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Neovascularization, Pathologic; Nestin; Neutrophil Infiltration; Neutrophils; Psoriasis; Receptor, Galanin, Type 2; Receptor, Galanin, Type 3; Severity of Illness Index; Skin | 2018 |
IL-1β and IL-23 Promote Extrathymic Commitment of CD27
Topics: Aminoquinolines; Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Interleukin-1beta; Interleukin-2 Receptor beta Subunit; Interleukin-23; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Interleukin; T-Lymphocytes; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 2017 |
Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue.
Topics: Animals; Calcitriol; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Interleukin-12 Subunit p40; Interleukin-17; Interleukin-23 Subunit p19; Mice; Psoriasis; Th17 Cells | 2018 |
Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice.
Topics: Aminoquinolines; Animals; Imiquimod; Interleukin-17; Lactobacillus pentosus; Mice; Psoriasis | 2017 |
Effect of Topical Application of Black Seed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino Rats.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Chemotherapy, Adjuvant; Dermis; Disease Models, Animal; Epidermis; Fibrillar Collagens; Humans; Imiquimod; Male; Nigella sativa; Plant Oils; Psoriasis; Rats; Seeds; Treatment Outcome | 2018 |
CD100-Plexin-B2 Promotes the Inflammation in Psoriasis by Activating NF-κB and the Inflammasome in Keratinocytes.
Topics: Animals; Antigens, CD; Biopsy; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Gene Expression Regulation; Healthy Volunteers; Humans; Imiquimod; Inflammasomes; Keratinocytes; Mice, Inbred BALB C; Nerve Tissue Proteins; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Primary Cell Culture; Protein Binding; Psoriasis; RNA, Small Interfering; Semaphorins; Signal Transduction; Skin | 2018 |
Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate T
Topics: Administration, Cutaneous; Adult; Aged; Biomarkers; Case-Control Studies; Dendritic Cells; Dermatitis, Contact; Female; Flow Cytometry; Humans; Imiquimod; Immunohistochemistry; Male; Middle Aged; Models, Biological; Psoriasis; Real-Time Polymerase Chain Reaction; Th17 Cells; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2018 |
How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?
Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Imiquimod; Immunosuppressive Agents; Male; Mice; Mice, Hairless; Mice, Inbred BALB C; Psoriasis; Skin; Tacrolimus; Treatment Outcome | 2018 |
IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice.
Topics: Animals; Cell Differentiation; CX3C Chemokine Receptor 1; Dermatitis, Atopic; Disease Models, Animal; Gene Expression Regulation; Imiquimod; Interleukin-17; Lectins, C-Type; Lipopolysaccharides; Macrophage Activation; Macrophages; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Transgenic; Nitric Oxide Synthase Type II; Phosphoproteins; Psoriasis; Receptors, Cell Surface; Signal Transduction; Skin; STAT1 Transcription Factor; STAT3 Transcription Factor | 2017 |
Thalidomide Improves Psoriasis-like Lesions and Inhibits Cutaneous VEGF Expression without Alteration of Microvessel Density in Imiquimod- induced Psoriatic Mouse Model.
Topics: Acitretin; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Female; Imiquimod; Mice, Inbred BALB C; Microvessels; Neovascularization, Pathologic; Psoriasis; Signal Transduction; Skin; Thalidomide; Vascular Endothelial Growth Factor A | 2018 |
Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model.
Topics: Aminoquinolines; Animals; Chitin; Disease Models, Animal; Drug Delivery Systems; Humans; Imiquimod; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; THP-1 Cells | 2018 |
Oral Administration of Vanillin Improves Imiquimod-Induced Psoriatic Skin Inflammation in Mice.
Topics: Aminoquinolines; Animals; Benzaldehydes; Female; Humans; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2017 |
High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.
Topics: Animals; Chemokine CCL20; Dermatitis; Diet, High-Fat; Disease Models, Animal; Endothelial Cells; Imiquimod; Interleukin-17; Keratinocytes; Male; Mice, Inbred C57BL; Mice, Obese; Obesity; Psoriasis; Skin; T-Lymphocytes | 2017 |
Anti-Psoriasis Effects and Mechanisms of Α-(8-Quinolinoxy) Zinc Phthalocyanine-Mediated Photodynamic Therapy.
Topics: Aminoquinolines; Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Epidermis; Epithelial Cells; Female; Guinea Pigs; Humans; Imiquimod; Indoles; Interleukin-17; Isoindoles; Lasers; Male; Mice; Mice, Inbred ICR; Mice, Nude; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Propranolol; Psoriasis; Zinc Compounds | 2017 |
Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-κB pathways.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Dermatitis; Disease Models, Animal; Docosahexaenoic Acids; Drug Evaluation, Preclinical; Humans; Imiquimod; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Psoriasis; Severity of Illness Index; Signal Transduction; Skin; Skin Cream | 2018 |
Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.
Topics: Animals; B7-H1 Antigen; Bone Marrow Cells; CD4-Positive T-Lymphocytes; Cell Differentiation; Dendritic Cells; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Lymph Nodes; Mice; Plasma Gases; Psoriasis; Th17 Cells | 2017 |
Essential Role of CARD14 in Murine Experimental Psoriasis.
Topics: Aminoquinolines; Animals; CARD Signaling Adaptor Proteins; Chimera; Guanylate Kinases; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Langerhans Cells; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Molecular Targeted Therapy; Psoriasis; Skin; T-Lymphocytes; Toll-Like Receptor 7; Toll-Like Receptor 9; Transcriptome | 2018 |
Liver fibrosis is associated with cutaneous inflammation in the imiquimod-induced murine model of psoriasiform dermatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Eruptions; Imiquimod; Interferon Inducers; Liver Cirrhosis; Male; Mice, Inbred C57BL; Psoriasis | 2018 |
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17.
Topics: Adenine; Adenosylhomocysteinase; Administration, Topical; Animals; Anti-Inflammatory Agents; Butyrates; Cells, Cultured; Cytokines; Female; Humans; Imiquimod; Keratinocytes; Mice, Inbred BALB C; Psoriasis; T-Lymphocytes | 2018 |
Decrease of galectin-3 in keratinocytes: A potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis.
Topics: Animals; Biomarkers; Cells, Cultured; Disease Models, Animal; Disease Progression; Galectin 3; Humans; Imiquimod; Inflammation; Keratinocytes; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Phenylurea Compounds; Psoriasis; Receptors, Interleukin-8B; Signal Transduction; Skin | 2018 |
IL-35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells.
Topics: Acute Disease; Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukins; Lymphocytes; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Psoriasis; Recombinant Proteins; T-Lymphocytes; Vascular Endothelial Growth Factor A | 2018 |
Interleukin-21 receptor signalling is not critically required for imiquimod-induced psoriasiform dermatitis in mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Dermatitis; Imiquimod; Inflammation; Interferon Inducers; Interleukin-21 Receptor alpha Subunit; Interleukin-23 Subunit p19; Intraepithelial Lymphocytes; Mice; Mice, Knockout; Mice, Transgenic; Psoriasis; Receptors, Interleukin-21; Signal Transduction | 2018 |
High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice.
Topics: Animals; Body Weight; Cholesterol; Cytokines; Dermatitis; Diet, High-Fat; Disease Models, Animal; Disease Progression; Hyperlipidemias; Imiquimod; Inflammasomes; Inflammation; Male; Mice; Mice, Inbred C57BL; Neutrophils; Psoriasis; Skin | 2018 |
Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.
Topics: Acetophenones; Adjuvants, Immunologic; Adolescent; Adult; Aminoquinolines; Animals; Apoptosis; Autophagy; Benzopyrans; Cell Proliferation; Cells, Cultured; Female; Humans; Imiquimod; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Middle Aged; NF-kappa B; Psoriasis; Reactive Oxygen Species; Young Adult | 2017 |
The expression of mCTLA-4 in skin lesion inversely correlates with the severity of psoriasis.
Topics: Adult; Aged; Aminoquinolines; Animals; Biopsy; CTLA-4 Antigen; Female; Humans; Imiquimod; Male; Mice; Mice, Inbred BALB C; Middle Aged; Psoriasis; Severity of Illness Index; Skin | 2018 |
NB-UVB irradiation downregulates keratin-17 expression in keratinocytes by inhibiting the ERK1/2 and STAT3 signaling pathways.
Topics: Aminoquinolines; Animals; Apoptosis; Biomarkers; Cell Line; Cell Proliferation; Disease Models, Animal; Down-Regulation; Female; Healthy Volunteers; Humans; Imiquimod; Keratin-17; Keratinocytes; Keratins; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Primary Cell Culture; Psoriasis; Radiation Dosage; Signal Transduction; Skin; STAT3 Transcription Factor; Treatment Outcome; Ultraviolet Therapy | 2018 |
Antiproliferation of keratinocytes and alleviation of psoriasis by the ethanol extract of Artemisia capillaris.
Topics: Aminoquinolines; Animals; Apoptosis; Artemisia; Cell Line; Cell Proliferation; Disease Models, Animal; Ethanol; Female; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Plant Extracts; Psoriasis | 2018 |
Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties.
Topics: Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Antioxidants; Betamethasone; Cell Death; Cell Line; Cell Survival; Disease Models, Animal; Drug Compounding; Drug Liberation; Ear; Edema; Humans; Imiquimod; Inflammation; Keratinocytes; Lipids; Mice, Inbred BALB C; Nanoparticles; Particle Size; Permeability; Psoriasis; Rheology; Skin; Sus scrofa; Thymol | 2018 |
Cryptotanshinone reduces psoriatic epidermal hyperplasia via inhibiting the activation of STAT3.
Topics: Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Drugs, Chinese Herbal; Epidermis; Humans; Hyperplasia; Imiquimod; Keratinocytes; Male; Mice, Inbred C57BL; Phenanthrenes; Psoriasis; STAT3 Transcription Factor | 2018 |
IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis.
Topics: Animals; Cell Polarity; Imiquimod; Interleukin-23; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis | 2018 |
Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation.
Topics: Amyloid Precursor Protein Secretases; Animals; Cell Differentiation; Dipeptides; Down-Regulation; Imiquimod; Inflammation; Interleukin-17; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Receptors, Notch; RNA, Messenger; Skin; Splenomegaly; Th17 Cells | 2018 |
p38α signaling in Langerhans cells promotes the development of IL-17-producing T cells and psoriasiform skin inflammation.
Topics: Animals; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Imidazoles; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Interleukin-6; Langerhans Cells; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 14; Psoriasis; Pyridines; Signal Transduction; Skin; T-Lymphocytes; Th17 Cells | 2018 |
Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice.
Topics: 5-Methylcytosine; Aminoquinolines; Animals; Case-Control Studies; Cell Differentiation; Cell Proliferation; Chemokine CXCL1; Dioxygenases; Disease Models, Animal; Disease Progression; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Humans; Imiquimod; Interferon-gamma; Interleukin-17; Mice, Inbred BALB C; Proto-Oncogene Proteins; Psoriasis; Skin; Time Factors | 2018 |
Anti-IL-12/IL-23p40 antibody ameliorates dermatitis and skin barrier dysfunction in mice with imiquimod-induced psoriasis-like dermatitis.
Topics: Aminoquinolines; Animals; Antibodies, Monoclonal; Cell Proliferation; Dermatitis; Imiquimod; Interleukin-12; Interleukin-23; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2018 |
Imiquimod-Induced Psoriasis-Like Skin Lesions Do Not Accelerate Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.
Topics: Animals; Atherosclerosis; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Knockout; Psoriasis; Receptors, LDL; Skin Diseases | 2018 |
TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Line; Disease Models, Animal; Female; Humans; Imiquimod; Male; Mice; Mice, Knockout; Neurons; Oximes; Psoriasis; Skin; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model.
Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Imiquimod; Methoxsalen; Mice, Inbred BALB C; Photosensitizing Agents; Psoriasis; PUVA Therapy; Signal Transduction; Skin; Time Factors | 2018 |
Topical heat shock protein 70 prevents imiquimod-induced psoriasis-like inflammation in mice.
Topics: Administration, Cutaneous; Animals; Cytokines; HSP70 Heat-Shock Proteins; Imiquimod; Inflammation; Mice, Inbred BALB C; Psoriasis; Skin Cream | 2018 |
MAPK Phosphatase-1 Deficiency Exacerbates the Severity of Imiquimod-Induced Psoriasiform Skin Disease.
Topics: Animals; Cytokines; Dual Specificity Phosphatase 1; Imiquimod; Inflammation Mediators; Macrophages; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Severity of Illness Index; Skin; Skin Diseases | 2018 |
An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation.
Topics: Animals; Cell Line; Cell Proliferation; Enzyme Activation; HEK293 Cells; Humans; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Interleukin; Receptors, Interleukin-17; Skin; STAT3 Transcription Factor | 2018 |
Resident and monocyte-derived Langerhans cells are required for imiquimod-induced psoriasis-like dermatitis model.
Topics: Aminoquinolines; Animals; Antigens, CD; Cytokines; Dendritic Cells; Disease Models, Animal; Epidermal Cells; Epidermis; Female; Gene Expression Profiling; Humans; Imiquimod; Langerhans Cells; Lectins, C-Type; Male; Mannose-Binding Lectins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocytes; Psoriasis | 2018 |
RIPK1 downregulation in keratinocyte enhances TRAIL signaling in psoriasis.
Topics: Aminoquinolines; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Down-Regulation; Epidermal Cells; Epidermis; Female; Gene Knockdown Techniques; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred C57BL; Primary Cell Culture; Psoriasis; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand | 2018 |
Glabridin, an isoflavan from licorice root, ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cytokines; Glycyrrhiza; Humans; Imiquimod; Isoflavones; Mice, Inbred BALB C; Nitric Oxide; Oxidative Stress; Phenols; Plant Roots; Psoriasis | 2018 |
Topically applied azaphenothiazines inhibit experimental psoriasis in mice.
Topics: Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Caspases; Cell Line; Cytokines; Disease Models, Animal; fas Receptor; Female; HCT116 Cells; Humans; Imiquimod; Jurkat Cells; Leukocyte Count; Lipopolysaccharides; Mice, Inbred BALB C; NF-kappa B; Phenothiazines; Psoriasis; Skin | 2018 |
Thromboxane A
Topics: Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Receptors, G-Protein-Coupled; Receptors, Thromboxane A2, Prostaglandin H2; T-Lymphocytes; Thromboxane A2; Thromboxane-A Synthase | 2018 |
The Therapeutic Potential and Molecular Mechanism of Isoflavone Extract against Psoriasis.
Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Epidermis; Foreskin; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukins; Isoflavones; Keratinocytes; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Signal Transduction; Skin; Tumor Necrosis Factor-alpha | 2018 |
Gold lotion from citrus peel extract ameliorates imiquimod-induced psoriasis-like dermatitis in murine.
Topics: Aminoquinolines; Animals; Citrus; Cytokines; Dermatitis; Fruit; Humans; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Psoriasis | 2018 |
NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis.
Topics: Adult; Animals; Cell Line; Cells, Cultured; Cytokines; Female; Humans; Imiquimod; Interleukin-17; Male; Mice, Inbred BALB C; Middle Aged; NF-kappa B p50 Subunit; Psoriasis; Skin; Th1 Cells; Young Adult | 2018 |
IDO-expressing Fibroblasts Suppress the Development of Imiquimod-induced Psoriasis-like Dermatitis.
Topics: Animals; Dermatitis; Female; Fibroblasts; Flow Cytometry; Imiquimod; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis | 2018 |
Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model.
Topics: Animals; Calgranulin A; Calgranulin B; Cell Proliferation; Cytokines; Disease Models, Animal; Epidermis; Humans; Imiquimod; Keratinocytes; Membrane Proteins; Mice; Mice, Knockout; Protective Factors; Proteins; Psoriasis; RNA, Messenger; Skin | 2018 |
Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation.
Topics: Animals; Cell Differentiation; Cell Proliferation; Epidermis; Gene Expression Regulation; Glucocorticoids; Imiquimod; Inflammation; Keratinocytes; Mice, Knockout; NF-kappa B; Phenotype; Phosphorylation; Psoriasis; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Signal Transduction; Tetradecanoylphorbol Acetate | 2018 |
IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
Topics: Adjuvants, Immunologic; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cells, Cultured; Chemokines; Colitis; Dendritic Cells; Dextran Sulfate; Fibroblasts; Imiquimod; Interleukin-1; Keratinocytes; Langerhans Cells; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Th17 Cells; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2018 |
Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro.
Topics: Aminoquinolines; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Proliferation; Coculture Techniques; Cytokines; Dendritic Cells; Erythema; Imiquimod; Inflammation; Interleukin-12 Subunit p35; Interleukin-23 Subunit p19; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger; Signal Transduction; Spleen; Toll-Like Receptor 7; Toll-Like Receptor 8; Triterpenes | 2018 |
Extracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis.
Topics: Adenosine Triphosphate; Animals; Dermatitis; Disease Models, Animal; Extracellular Space; Female; Humans; Imiquimod; Inflammation Mediators; Interleukin-17; Interleukin-1beta; Interleukin-23; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Receptors, Purinergic P2X7; Signal Transduction; Skin | 2018 |
C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes.
Topics: Adolescent; Adult; Animals; Antimicrobial Cationic Peptides; Cell Line; Cell Proliferation; Child; Disease Models, Animal; DNA-Binding Proteins; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression; Humans; Imiquimod; Keratinocytes; Male; Mice, Inbred BALB C; Middle Aged; Psoriasis; RNA Interference; Signal Transduction; Skin; Young Adult | 2018 |
Mild electrical stimulation with heat shock reduces inflammatory symptoms in the imiquimod-induced psoriasis mouse model.
Topics: Animals; beta-Defensins; Calgranulin A; Calgranulin B; CD3 Complex; Cell Line; Cell Movement; Cell Proliferation; Combined Modality Therapy; Disease Models, Animal; Electric Stimulation Therapy; Female; Gene Expression; Humans; Hyperplasia; Hyperthermia, Induced; Imiquimod; Interleukin-17; Keratinocytes; Mice; Pancreatitis-Associated Proteins; Psoriasis; RNA, Messenger; Skin; T-Lymphocytes | 2018 |
Decryption of Active Constituents and Action Mechanism of the Traditional Uighur Prescription (BXXTR) Alleviating IMQ-Induced Psoriasis-Like Skin Inflammation in BALB/c Mice.
Topics: Aminoquinolines; Animals; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Humans; Imiquimod; Interleukin-17; Interleukin-18; Interleukin-23; Keratinocytes; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Psoriasis; Severity of Illness Index; Signal Transduction; Skin; Toll-Like Receptor 8; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2018 |
Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.
Topics: Adaptor Proteins, Signal Transducing; Animals; CARD Signaling Adaptor Proteins; Cell Line; Cytokines; Dermatitis; Gain of Function Mutation; Gene Expression Regulation; Guanylate Kinases; HEK293 Cells; Humans; Imiquimod; Interleukin-17; Keratinocytes; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Psoriasis; Signal Transduction; T-Lymphocyte Subsets; TNF Receptor-Associated Factor 6 | 2018 |
Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.
Topics: Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Keratinocytes; Membrane Proteins; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Psoriasis; RNA; Signal Transduction; Skin | 2019 |
miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A.
Topics: 3' Untranslated Regions; Animals; Down-Regulation; Female; Humans; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; MicroRNAs; Psoriasis | 2018 |
Rapamycin ameliorates psoriasis by regulating the expression and methylation levels of tropomyosin via ERK1/2 and mTOR pathways in vitro and in vivo.
Topics: Animals; Cell Proliferation; Cytoskeleton; Down-Regulation; Female; Gene Expression; HEK293 Cells; Humans; Imiquimod; Immunosuppressive Agents; Keratinocytes; Male; MAP Kinase Signaling System; Methylation; Mice; Psoriasis; S Phase Cell Cycle Checkpoints; Sirolimus; TOR Serine-Threonine Kinases; Tropomyosin | 2018 |
Chlamydial Plasmid-Encoded Protein pGP3 Inhibits Development of Psoriasis-Like Lesions in Mice.
Topics: Aminoquinolines; Animals; Antigens, Bacterial; Antimicrobial Cationic Peptides; Bacterial Proteins; Cathelicidins; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin | 2018 |
Chitosan-based nanoformulated (-)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis.
Topics: Administration, Topical; Aminoquinolines; Animals; Antineoplastic Agents; Antioxidants; Catechin; Cell Differentiation; Cells, Cultured; Chitosan; Dermatitis; Filaggrin Proteins; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis | 2018 |
Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-17; Intraepithelial Lymphocytes; Keratinocytes; Male; Mice; Mice, Knockout; Primary Cell Culture; Psoriasis; Receptors, Interleukin-17; Signal Transduction; Skin; TNF Receptor-Associated Factor 6 | 2018 |
Local production of prolactin in lesions may play a pathogenic role in psoriatic patients and imiquimod-induced psoriasis-like mouse model.
Topics: Adult; Aged; Animals; Cabergoline; Cytokines; Dermis; Disease Models, Animal; Dopamine Agonists; Epidermis; Female; Humans; Imiquimod; Male; Methylcellulose; Mice; Middle Aged; Prolactin; Psoriasis; Receptors, Prolactin; Risk Adjustment; RNA, Messenger; Solvents; TRPV Cation Channels | 2018 |
Tetrathiomolybdate, a copper chelator inhibited imiquimod-induced skin inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents; Chelating Agents; Copper; Cytokines; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Imiquimod; Inflammation Mediators; Keratinocytes; Male; Mice, Inbred C57BL; Molybdenum; Phosphorylation; Psoriasis; Signal Transduction; Skin; Spleen; STAT3 Transcription Factor | 2018 |
Overexpression of Wilms' tumor 1 in skin lesions of psoriasis is associated with abnormal proliferation and apoptosis of keratinocytes.
Topics: Adolescent; Adult; Animals; Apoptosis; Case-Control Studies; Cell Proliferation; Disease Models, Animal; Female; Gene Knockdown Techniques; Humans; Imiquimod; Inflammation; Keratinocytes; Male; Mice, Inbred BALB C; Middle Aged; Psoriasis; Skin; WT1 Proteins; Young Adult | 2018 |
Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Curcumin; Dermatitis; Drug Carriers; Imiquimod; Lipids; Male; Mice; Nanofibers; Psoriasis | 2018 |
The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption.
Topics: Animals; Benzofurans; Coumarins; Female; Furocoumarins; Imiquimod; Keratinocytes; Mice, Inbred BALB C; Mice, Nude; Phenols; Photochemotherapy; Psoralea; Psoriasis; PUVA Therapy; Skin; Skin Absorption; Swine; Ultraviolet Rays | 2018 |
Dendrimer as a new potential carrier for topical delivery of siRNA: A comparative study of dendriplex vs. lipoplex for delivery of TNF-α siRNA.
Topics: Animals; Cytokines; Dendrimers; Fatty Acids, Monounsaturated; Gene Transfer Techniques; Imiquimod; Liposomes; Mice, Inbred BALB C; Psoriasis; Quaternary Ammonium Compounds; RNA, Small Interfering; Skin | 2018 |
The vitamin D
Topics: Adoptive Transfer; Animals; Betamethasone Valerate; Calcitriol; Dermatologic Agents; Down-Regulation; Female; Humans; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis; Skin; T-Lymphocytes, Regulatory; Treatment Outcome | 2018 |
Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production.
Topics: Administration, Cutaneous; Aminoquinolines; Angelica sinensis; Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Imiquimod; Inflammation; Interleukin-22; Interleukins; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Th17 Cells; Tumor Necrosis Factor-alpha | 2018 |
Is CCR6 Required for the Development of Psoriasiform Dermatitis in Mice?
Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Knockout; Psoriasis; Receptors, CCR6; Skin | 2019 |
[Effect of methotrexate on regulation for the number of regulatory T cells and expression of Foxp3 in psoriasis].
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Case-Control Studies; Female; Forkhead Transcription Factors; Humans; Imiquimod; Immunosuppressive Agents; Lymphocyte Count; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Random Allocation; RNA, Messenger; Spleen; T-Lymphocytes, Regulatory | 2018 |
Epidermal mast cells in Bowenoid papulosis during topical imiquimod therapy.
Topics: Administration, Cutaneous; Aged; Biopsy; Bowen's Disease; Epidermis; Glucocorticoids; Humans; Imiquimod; Male; Mast Cells; Psoriasis; Scrotum; Skin Neoplasms; Treatment Outcome | 2019 |
Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.
Topics: Animals; Calcitonin Gene-Related Peptide; Denervation; Disease Models, Animal; Diterpenes; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Psoriasis; Reactive Nitrogen Species; Reactive Oxygen Species; Sensory Receptor Cells; Skin; Substance P; TRPA1 Cation Channel; TRPV Cation Channels | 2019 |
5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis probably through inhibition of IL-17A production and keratinocyte activation.
Topics: 5-Hydroxytryptophan; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Epidermis; Humans; Imiquimod; Interferon-gamma; Interleukin-17; Interleukin-6; Keratinocytes; Ki-67 Antigen; Male; Mice; Mice, Inbred C57BL; Protein Biosynthesis; Psoriasis; Spleen; Tumor Necrosis Factor-alpha | 2018 |
Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice.
Topics: Animals; Anti-Inflammatory Agents; CD8-Positive T-Lymphocytes; Cyclooxygenase 2; Cytokines; Female; Imiquimod; Ketones; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Psoriasis; Sesquiterpenes | 2018 |
Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4
Topics: Animals; CD8-Positive T-Lymphocytes; Cytokines; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; T-Lymphocytes, Regulatory; Umbelliferones | 2018 |
A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice.
Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Transgenic; Psoriasis; Skin; Toll-Like Receptor 7 | 2018 |
Downregulation of miR-145-5p contributes to hyperproliferation of keratinocytes and skin inflammation in psoriasis.
Topics: Adult; Animals; Antagomirs; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Down-Regulation; Female; Gene Expression Profiling; Humans; Imiquimod; Keratinocytes; Male; MAP Kinase Kinase Kinases; Mice; MicroRNAs; Mitogen-Activated Protein Kinase Kinase Kinase 11; Oligonucleotide Array Sequence Analysis; Primary Cell Culture; Psoriasis; Skin; Young Adult | 2019 |
Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred C57BL; Nanoparticles; Psoriasis; Skin | 2018 |
Macrophages express βKlotho in skin lesions of psoriatic patients and the skin of imiquimod-treated mice.
Topics: Adult; Aged; Animals; Antibodies, Neutralizing; Case-Control Studies; Dermatitis, Atopic; Disease Models, Animal; Down-Regulation; Female; Humans; Imiquimod; Immunohistochemistry; Interleukin-17; Klotho Proteins; Macrophages; Male; Membrane Proteins; Mice; Middle Aged; Psoriasis; Skin | 2018 |
The small molecule rhodomyrtone suppresses TNF-α and IL-17A-induced keratinocyte inflammatory responses: A potential new therapeutic for psoriasis.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; NF-kappa B; Organ Culture Techniques; Psoriasis; Signal Transduction; Skin; Tumor Necrosis Factor-alpha; Xanthones | 2018 |
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-23; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Mice; Mice, Knockout; Psoriasis; Skin | 2018 |
IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity.
Topics: Animals; Cell Movement; Dendritic Cells; Dermatitis; Dermatitis, Contact; Haptens; Imiquimod; Inflammation; Interleukin-1; Keratinocytes; Lymph Nodes; Mice, Inbred C57BL; Psoriasis; Skin; T-Lymphocytes | 2018 |
Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis.
Topics: Animals; Antibodies, Blocking; Aorta; Disease Models, Animal; Disease Progression; Humans; Imiquimod; Immunotherapy; Inflammation; Interleukin-17; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Oxidative Stress; Psoriasis; Reactive Oxygen Species; Skin; Vascular Diseases | 2019 |
Ameliorative effects of a fusion protein dual targeting interleukin 17A and tumor necrosis factor α on imiquimod-induced psoriasis in mice.
Topics: Animals; Antigens, Ly; Caspase 14; Etanercept; Female; Filaggrin Proteins; Imiquimod; Interleukin-17; Intermediate Filament Proteins; Keratin-16; Keratin-17; Keratin-6; Mice; Mice, Inbred BALB C; Psoriasis; Tumor Necrosis Factor-alpha | 2018 |
IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment.
Topics: Adolescent; Adult; Aged; Animals; Antibodies, Monoclonal, Humanized; Case-Control Studies; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation; Humans; Imiquimod; Immunologic Factors; Interleukin-1; Interleukin-17; Interleukins; Keratinocytes; Male; Mice; Middle Aged; Primary Cell Culture; Psoriasis; Receptors, Interleukin-1; Severity of Illness Index; Signal Transduction; Skin | 2018 |
Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aza Compounds; Disease Models, Animal; Fatty Acids, Omega-3; Humans; Imiquimod; Mice; Mice, Inbred C57BL; Pemphigoid, Bullous; Psoriasis; Receptors, G-Protein-Coupled; Treatment Outcome | 2018 |
Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis.
Topics: Animals; Antipruritics; Behavior, Animal; Disease Models, Animal; Imiquimod; Interleukin-22; Interleukin-23; Interleukins; Janus Kinase Inhibitors; Male; Mice, Inbred C57BL; Nerve Fibers; Piperidines; Pruritus; Psoriasis; Pyrimidines; Pyrroles; Skin | 2019 |
ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; Humans; Imiquimod; Interleukin-12; Interleukin-17; Interleukin-6; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors; Psoriasis; raf Kinases; Signal Transduction; Skin; Small Molecule Libraries; Th17 Cells | 2019 |
Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression.
Topics: Animals; Anti-Inflammatory Agents; Ascorbic Acid; Cytokines; Female; Imiquimod; Mice, Inbred C57BL; Psoriasis; Skin | 2018 |
Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.
Topics: Animals; B-Lymphocytes; Cell Movement; Colitis; Dermatitis; Dextran Sulfate; Disease Progression; Fecal Microbiota Transplantation; Female; Gastrointestinal Microbiome; Hematopoietic Stem Cells; Imiquimod; Immunoglobulin D; Immunoglobulin M; Intestines; Lactobacillus; Lymph Nodes; Lymphocyte Depletion; Mice, Inbred C57BL; Permeability; Psoriasis; Toll-Like Receptor 7 | 2019 |
TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.
Topics: Animals; Cytokines; Disease Models, Animal; Epidermis; Female; Humans; Hyperplasia; Imiquimod; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; TRPV Cation Channels; Water Loss, Insensible | 2018 |
Anti-psoriatic effect of myeloid-derived suppressor cells on imiquimod-induced skin inflammation in mice.
Topics: Animals; Cytokines; Dermatitis; Female; Imiquimod; Mice; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Psoriasis; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells | 2019 |
Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice.
Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Quinazolines; Signal Transduction; Skin; Skin Diseases; Th17 Cells; Toll-Like Receptor 7 | 2019 |
Disinhibition of Touch-Evoked Itch in a Mouse Model of Psoriasis.
Topics: Animals; Disease Models, Animal; Epidermis; Humans; Imiquimod; Interneurons; Male; Merkel Cells; Mice; Neurofilament Proteins; Pruritus; Psoriasis; Touch | 2019 |
A Western Diet, but Not a High-Fat and Low-Sugar Diet, Predisposes Mice to Enhanced Susceptibility to Imiquimod-Induced Psoriasiform Dermatitis.
Topics: Animals; Diet, Carbohydrate-Restricted; Diet, High-Fat; Diet, Western; Dietary Sugars; Disease Models, Animal; Disease Susceptibility; Female; Humans; Imiquimod; Mice; Obesity; Psoriasis | 2019 |
Structure-based drug designing and identification of Woodfordia fruticosa inhibitors targeted against heat shock protein (HSP70-1) as suppressor for Imiquimod-induced psoriasis like skin inflammation in mice model.
Topics: Animals; Disease Models, Animal; Gold; Heat-Shock Proteins; Humans; Imiquimod; Metal Nanoparticles; Mice; Molecular Docking Simulation; Psoriasis; Skin Diseases; Woodfordia | 2019 |
Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation.
Topics: Adult; Aged; Aged, 80 and over; Animals; Female; Forkhead Transcription Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imiquimod; Inflammation; Male; Mice, Inbred C57BL; Middle Aged; Neutralization Tests; Phagocytes; Psoriasis; Receptors, Antigen, T-Cell, alpha-beta; Skin; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory | 2018 |
Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Topics: Administration, Topical; Allosteric Site; Animals; Carbon; Cell Line; Down-Regulation; Humans; Imiquimod; Keratinocytes; Male; Metabolomics; Methionine Adenosyltransferase; Mice; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Psoriasis; Triterpenes | 2019 |
IL-23- and Imiquimod-Induced Models of Experimental Psoriasis in Mice.
Topics: Adjuvants, Immunologic; Administration, Topical; Animals; Cytokines; Disease Models, Animal; Flow Cytometry; Imiquimod; Injections, Intradermal; Interleukin-23; Mice; Psoriasis; Skin | 2019 |
Human amnion-derived mesenchymal stem cells ameliorate imiquimod-induced psoriasiform dermatitis in mice.
Topics: Amnion; Animals; Cells, Cultured; Chemokines; Culture Media, Conditioned; Disease Models, Animal; Humans; Imiquimod; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Primary Cell Culture; Psoriasis; Skin; Treatment Outcome; Umbilical Cord | 2019 |
Mechanical Stretch Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Epidermis; Humans; Imiquimod; Inflammation Mediators; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Stress, Mechanical; Tight Junctions | 2019 |
Downregulated Caveolin-1 expression in circulating monocytes may contribute to the pathogenesis of psoriasis.
Topics: Animals; Caveolin 1; Chemotaxis; Down-Regulation; Humans; Imiquimod; Inflammation; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Mice; Monocytes; Psoriasis | 2019 |
Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway.
Topics: Animals; Blotting, Western; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Hesperidin; Humans; Imiquimod; Keratinocytes; Lipopolysaccharides; Male; MAP Kinase Signaling System; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Real-Time Polymerase Chain Reaction | 2019 |
Cold atmospheric plasma ameliorates imiquimod-induced psoriasiform dermatitis in mice by mediating antiproliferative effects.
Topics: Animals; Antineoplastic Agents; Apoptosis; Dermatitis; Female; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Plasma Gases; Psoriasis | 2019 |
Imiquimod-Induced Psoriasis in Mice Depends on the IL-17 Signaling of Keratinocytes.
Topics: Adjuvants, Immunologic; Animals; Biopsy, Needle; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Flow Cytometry; Imiquimod; Immunohistochemistry; Interleukin-17; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Psoriasis; Random Allocation; Real-Time Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
Ghrelin protects against contact dermatitis and psoriasiform skin inflammation by antagonizing TNF-α/NF-κB signaling pathways.
Topics: Animals; Dermatitis, Contact; Disease Models, Animal; Fibroblasts; Gene Expression Regulation; Ghrelin; Humans; Imiquimod; Immune System Diseases; Inflammation; Mice; NF-kappa B; Oxazolone; Psoriasis; RAW 264.7 Cells; Signal Transduction; Skin; Tumor Necrosis Factor-alpha | 2019 |
Interleukin-18 exacerbates skin inflammation and affects microabscesses and scale formation in a mouse model of imiquimod-induced psoriasis.
Topics: Animals; Chemokine CXCL1; Cytokines; Disease Models, Animal; Imiquimod; Interleukin-17; Interleukin-18; Mice; Mice, Knockout; Psoriasis; Skin | 2019 |
Genistein suppresses psoriasis-related inflammation through a STAT3-NF-κB-dependent mechanism in keratinocytes.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Disease Models, Animal; Genistein; Heme; Humans; Imiquimod; Inflammation Mediators; Keratinocytes; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A | 2019 |
Dithranol-loaded nanostructured lipid carrier-based gel ameliorate psoriasis in imiquimod-induced mice psoriatic plaque model.
Topics: Administration, Cutaneous; Animals; Anthralin; Dermatologic Agents; Disease Models, Animal; Drug Carriers; Drug Liberation; Gels; Humans; Imiquimod; Lipids; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Ointments; Particle Size; Psoriasis; Severity of Illness Index; Skin; Treatment Outcome | 2019 |
Hyperglycemia Is Associated with Psoriatic Inflammation in Both Humans and Mice.
Topics: Animals; Blood Glucose; Cross-Sectional Studies; Disease Models, Animal; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Imiquimod; Insulin; Interleukin-17; Male; Mice; Middle Aged; Phototherapy; Psoriasis; Retrospective Studies; Severity of Illness Index; Skin; Treatment Outcome | 2019 |
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.
Topics: Administration, Topical; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Ceramidases; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Imiquimod; Immunity; Inflammation; Interleukin-17; Lysophospholipids; Male; Mice; Phosphotransferases (Alcohol Group Acceptor); Psoriasis; Quinolones; RNA, Messenger; Sphingosine; Suppressor of Cytokine Signaling 1 Protein; Th17 Cells | 2019 |
Methodological refinement of Aldara-induced psoriasiform dermatitis model in mice.
Topics: Animals; CD11b Antigen; Cytokines; Dermatitis; Disease Models, Animal; Female; Imiquimod; Mice, Inbred C57BL; Petrolatum; Psoriasis | 2019 |
cis-Khellactone Inhibited the Proinflammatory Macrophages via Promoting Autophagy to Ameliorate Imiquimod-Induced Psoriasis.
Topics: Adjuvants, Immunologic; Animals; Autophagy; Autophagy-Related Protein 7; Beclin-1; Cells, Cultured; Coumarins; Disease Models, Animal; Female; Gene Knockdown Techniques; Hepatocytes; Humans; Imiquimod; Macrophages; Male; Methotrexate; Mice; Mice, Inbred C57BL; Primary Cell Culture; Psoriasis; Toxicity Tests | 2019 |
Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes.
Topics: Animals; Anti-Inflammatory Agents; Berberine; Cell Cycle Proteins; Cell Line; Cell Proliferation; Disease Models, Animal; Female; Humans; Imiquimod; Janus Kinases; Keratinocytes; Mice; Mice, Inbred BALB C; Nuclear Proteins; Psoriasis; Signal Transduction; STAT3 Transcription Factor; Transfection | 2019 |
Cholecystokinin Downregulates Psoriatic Inflammation by Its Possible Self-Regulatory Effect on Epidermal Keratinocytes.
Topics: Animals; Autocrine Communication; Cholecystokinin; Down-Regulation; Epidermis; Female; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-6; Keratinocytes; Male; Mice; Oligopeptides; Paracrine Communication; Psoriasis; Signal Transduction | 2019 |
Imiquimod-induced skin inflammation is relieved by knockdown of sodium channel Na
Topics: Animals; Dermatitis; Epidermis; Female; Gene Knockdown Techniques; Imiquimod; Inflammation; Psoriasis; Rabbits; RNA Interference; Skin; Voltage-Gated Sodium Channels | 2019 |
IL-33 contributes to disease severity in Psoriasis-like models of mouse.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-33; Interleukins; Mice; Mice, Inbred BALB C; Psoriasis; Skin; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2019 |
Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms.
Topics: Ambroxol; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Humans; Hyperplasia; Imiquimod; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Psoriasis; RAW 264.7 Cells; Signal Transduction; Skin | 2019 |
GPR15 is not critically involved in the regulation of murine psoriasiform dermatitis.
Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Interleukin-23; Mice; Mice, Knockout; Psoriasis; Receptors, G-Protein-Coupled; Skin | 2019 |
IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.
Topics: Animals; Antibodies; Cell Differentiation; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-1; Interleukin-1 Receptor Accessory Protein; Interleukin-17; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Regeneration; Skin; T-Lymphocytes | 2019 |
Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight.
Topics: Animals; Imiquimod; Interleukin-17; Keratinocytes; Mice; Psoriasis; Skin | 2019 |
Imiquimod-induced widespread psoriasiform eruptions.
Topics: Administration, Cutaneous; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Imiquimod; Keratosis, Actinic; Psoriasis | 2019 |
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Topics: Animals; Cell Line; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Humans; Imiquimod; Mice; Psoriasis; Sirtuins | 2019 |
Ferulic acid altered IL-17A/IL-17RA interaction and protected against imiquimod-induced psoriasis-like skin injury in mice.
Topics: Adjuvants, Immunologic; Animals; Coumaric Acids; Female; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; Protein Binding; Psoriasis; Receptors, Interleukin-17 | 2019 |
Shikonin induces apoptosis and suppresses growth in keratinocytes via CEBP-δ upregulation.
Topics: Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-delta; Cell Line; Cell Proliferation; Humans; Imiquimod; Janus Kinases; Keratinocytes; Male; Mice, Inbred BALB C; Naphthoquinones; Psoriasis; STAT3 Transcription Factor; Up-Regulation | 2019 |
Synthesis and identification of quinoline derivatives as topoisomerase I inhibitors with potent antipsoriasis activity in an animal model.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Ear; Imiquimod; Inflammation; Male; Mice, Inbred BALB C; Psoriasis; Quinolines; Skin; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors | 2019 |
Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice.
Topics: Adult; Animals; Dermis; Epidermis; Female; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Keratosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Physiologic; Psoriasis; RNA, Messenger; Th17 Cells; TRPA1 Cation Channel | 2019 |
A Novel Surfactant-Free O/O Paclitaxel Ointment for the Topical Treatment of Psoriasis.
Topics: Administration, Topical; Animals; Humans; Imiquimod; Male; Mice; Mice, Inbred BALB C; Ointments; Paclitaxel; Particle Size; Psoriasis; Skin; Surface-Active Agents | 2019 |
[Knockdown of interleukin 20 receptor 2 (IL-20R2) inhibits the development of psoriasis induced by imiquimod in mice].
Topics: Animals; Gene Knockdown Techniques; Imiquimod; Mice; Mice, Knockout; Psoriasis; Receptors, Interleukin | 2019 |
Colloidal nanostructured lipid carriers of pentoxifylline produced by microwave irradiation ameliorates imiquimod-induced psoriasis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colloids; Drug Carriers; Imiquimod; Lipids; Male; Mice; Microwaves; Models, Molecular; Nanostructures; Particle Size; Pentoxifylline; Psoriasis; Rats; Rats, Wistar; Surface Properties | 2019 |
Caspase-11-Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis.
Topics: Animals; Caspases, Initiator; Cell Death; Cell Proliferation; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-1beta; Mice; Mice, Knockout; Neovascularization, Pathologic; Psoriasis; Ribonuclease, Pancreatic; Skin | 2019 |
Topics: Animals; Cytokines; Datura metel; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Gene Expression Regulation; Imiquimod; Male; Membrane Glycoproteins; Mice; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Signal Transduction; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2019 |
Ginsenoside compound K ameliorates imiquimod-induced psoriasis-like dermatitis through inhibiting REG3A/RegIIIγ expression in keratinocytes.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dermatitis; Female; Ginsenosides; Humans; Imiquimod; Interleukin-1; Keratinocytes; Mice; Mice, Inbred C57BL; Pancreatitis-Associated Proteins; Psoriasis; Skin | 2019 |
Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
Topics: Animals; Astragalus propinquus; Cell Movement; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammasomes; Inflammation; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Pyroptosis; Sapogenins; Skin | 2019 |
The Psoriasis Therapeutic Potential of a Novel Short Laminin Peptide C16.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Female; Fibronectins; Humans; Imiquimod; Integrin alpha5beta1; Keratinocytes; Laminin; Mice; Mice, Inbred C57BL; Peptide Fragments; Protein Binding; Psoriasis | 2019 |
Mannan-binding lectin promotes keratinocyte to produce CXCL1 and enhances neutrophil infiltration at the early stages of psoriasis.
Topics: Animals; Cell Line, Transformed; Chemokine CXCL1; Chemotaxis, Leukocyte; Dermis; Female; Humans; Imiquimod; Inflammation; Keratinocytes; Mannose-Binding Lectin; Metabolism, Inborn Errors; Mice; Mice, Knockout; Neutrophils; Psoriasis; Specific Pathogen-Free Organisms; Up-Regulation | 2019 |
E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis.
Topics: Animals; Cadherins; CD11c Antigen; Cell Differentiation; Cell Movement; Cell Shape; Cells, Cultured; Dermatitis, Contact; Disease Models, Animal; Epidermis; Homeostasis; Humans; Imiquimod; Langerhans Cells; Mice; Mice, Knockout; Psoriasis | 2020 |
Evidence on the direct correlation between miR-31 and IL-22 axis in IMQ-induced psoriasis.
Topics: Animals; Imiquimod; Interleukin-22; Interleukins; Mice; MicroRNAs; Psoriasis | 2019 |
Anti-psoriasis effect of water-processed rosin in mice.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Cell Proliferation; Cytokines; Female; Imiquimod; Mice, Inbred BALB C; Psoriasis; Resins, Plant; Skin; Spleen; Th1 Cells; Th17 Cells; Water | 2019 |
Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biomarkers; Cholesterol; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Female; Hexoses; Imiquimod; Interferon Inducers; Interleukins; Liposomes; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; Plant Extracts; Psoriasis; Skin; Spleen; Tripterygium; Triterpenes | 2019 |
Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway.
Topics: Animals; Cell Proliferation; Datura metel; Dermatitis; Humans; Imiquimod; Keratinocytes; MAP Kinase Signaling System; Mice; Psoriasis; STAT3 Transcription Factor; Withanolides | 2019 |
Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation.
Topics: Animals; Cytokines; Disease Models, Animal; Female; Glucosides; Guinea Pigs; Imiquimod; Male; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Paeonia; Phosphorylation; Plant Roots; Psoriasis; STAT1 Transcription Factor; STAT3 Transcription Factor | 2019 |
Anti-IL-17A and IL-23p19 antibodies but not anti-TNFα antibody induce expansion of regulatory T cells and restoration of their suppressive function in imiquimod-induced psoriasiform dermatitis.
Topics: Adoptive Transfer; Animals; Antibodies, Monoclonal; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-17; Interleukin-23 Subunit p19; Mice; Psoriasis; Signal Transduction; Skin; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Necrosis Factor-alpha | 2019 |
Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis.
Topics: Animals; Antigens, Dermatophagoides; Dermatitis, Atopic; Dietary Supplements; Disease Models, Animal; Eicosanoids; Eicosapentaenoic Acid; Humans; Imiquimod; Lipid Metabolism; Male; Mice; Pruritus; Psoriasis; Skin; Treatment Outcome | 2019 |
Investigating the Role of I Kappa B Kinase ε in the Pathogenesis of Psoriasis.
Topics: Animals; beta-Defensins; Biopsy; Chemokine CCL20; Chemokine CXCL1; Disease Models, Animal; Humans; I-kappa B Kinase; Imiquimod; Interleukin-17; Mice; Psoriasis; RNA, Messenger; Tumor Necrosis Factor-alpha | 2019 |
ALA-PDT alleviates the psoriasis by inhibiting JAK signalling pathway.
Topics: Aminolevulinic Acid; Animals; Drug Evaluation, Preclinical; Female; Imiquimod; Interferon-gamma; Janus Kinases; Keratinocytes; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Psoriasis; Reactive Oxygen Species; Signal Transduction; Suppressor of Cytokine Signaling Proteins | 2019 |
IL-1R1 signaling facilitates Munro's microabscess formation in psoriasiform imiquimod-induced skin inflammation.
Topics: Abscess; Adjuvants, Immunologic; Aminoquinolines; Animals; Animals, Newborn; Chemokine CXCL1; Chemokine CXCL2; Dermis; Drug Eruptions; Epidermal Cells; Humans; Imiquimod; Interleukin-1alpha; Interleukin-1beta; Keratinocytes; Mice; Mice, Knockout; Neutrophils; Primary Cell Culture; Psoriasis; Receptors, Interleukin-1 Type I; Signal Transduction | 2013 |
Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin.
Topics: Aminoquinolines; Animals; Antimicrobial Cationic Peptides; beta-Defensins; Cathelicidins; CCAAT-Enhancer-Binding Protein-alpha; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Nicotinamide Phosphoribosyltransferase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Psoriasis; Receptor, Insulin; RNA, Messenger; RNA, Small Interfering; S100 Calcium Binding Protein A7; S100 Proteins; Skin; STAT3 Transcription Factor; Toll-Like Receptors; Tumor Necrosis Factor-alpha | 2013 |
Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.
Topics: Aminoquinolines; Animals; Antigens, CD19; Antigens, CD1d; B-Lymphocytes, Regulatory; CD4-Positive T-Lymphocytes; CD5 Antigens; Humans; Imiquimod; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-17; Lymph Nodes; Lymphocyte Count; Mice; Mice, Inbred C57BL; Phenotype; Psoriasis; RNA, Messenger; Skin; Spleen | 2013 |
Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Cell Differentiation; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Imiquimod; Keratinocytes; Local Lymph Node Assay; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, SCID; Propylene Glycols; Psoriasis; Receptors, Lysosphingolipid; Skin; Skin Transplantation; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors | 2013 |
Mustard seed (Sinapis Alba Linn) attenuates imiquimod-induced psoriasiform inflammation of BALB/c mice.
Topics: Aminoquinolines; Animals; Catalase; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Glutathione Peroxidase; Imiquimod; Macrophages; Malondialdehyde; Mice; Mice, Inbred BALB C; Mustard Plant; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Preparations; Psoriasis; Seeds; Spleen; Superoxide Dismutase; T-Lymphocytes | 2013 |
Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.
Topics: Aminoquinolines; Animals; Antigens, Surface; Disease Models, Animal; Imiquimod; Interleukin-23; Langerhans Cells; Lectins, C-Type; Mannose-Binding Lectins; Membrane Glycoproteins; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; Psoriasis; Toll-Like Receptor 7 | 2013 |
Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice.
Topics: Aminoquinolines; Animals; Cell Proliferation; Curcumin; Ear; Gene Expression Regulation; Imiquimod; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Receptors, CCR6; RNA, Messenger; Skin | 2013 |
[Expression of NLRP3 inflammasome in BALB/c mice with imiquimod-induced psoriasis-like inflammation and therapeutic effect of mustard seed (Sinapis Alba Linn)].
Topics: Aminoquinolines; Animals; Carrier Proteins; Caspase 1; Female; Imiquimod; Inflammasomes; Inflammation; Interleukin-18; Interleukin-1beta; Mice; Mice, Inbred BALB C; Mustard Plant; NLR Family, Pyrin Domain-Containing 3 Protein; Phytotherapy; Psoriasis; Seeds | 2013 |
Editorial: are regulatory B10 cells a viable target for autoimmune diseases?
Topics: Aminoquinolines; Animals; B-Lymphocytes, Regulatory; Humans; Imiquimod; Inflammation; Psoriasis; Skin | 2013 |
TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Membrane Glycoproteins; Mice; Psoriasis; Receptors, Purinergic P1; Toll-Like Receptor 7; Toll-Like Receptor 8 | 2013 |
A comparison of the effects of topical treatment of calcipotriol, camptothecin, clobetasol and tazarotene on an imiquimod-induced psoriasis-like mouse model.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Calcitriol; Camptothecin; Clobetasol; Dermatologic Agents; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Nicotinic Acids; Psoriasis; Topoisomerase I Inhibitors | 2014 |
Prolactin induces the production of Th17 and Th1 cytokines/chemokines in murine Imiquimod-induced psoriasiform skin.
Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Imiquimod; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Prolactin; Psoriasis; Real-Time Polymerase Chain Reaction; Recombinant Proteins; RNA, Messenger; Th1 Cells; Th17 Cells | 2014 |
IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Dermatitis, Contact; Disease Models, Animal; Imiquimod; Interleukin-12; Interleukin-17; Interleukin-22; Interleukin-23 Subunit p19; Interleukins; Langerhans Cells; Lymph Nodes; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Receptors, CCR6; RNA, Messenger; Skin; Transplantation Chimera | 2014 |
Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function.
Topics: Acetylcysteine; Aminoquinolines; Animals; Dermatitis; Disease Progression; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hyperbaric Oxygenation; Imiquimod; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, Inbred C57BL; NADPH Oxidases; Naphthoquinones; Psoriasis; Reactive Oxygen Species; T-Lymphocytes, Regulatory | 2014 |
Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Chemotaxis, Leukocyte; Disease Models, Animal; Imiquimod; Immunohistochemistry; Keratinocytes; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Psoriasis; Real-Time Polymerase Chain Reaction; Receptors, Interleukin-8B; Receptors, Leukotriene B4 | 2014 |
Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis.
Topics: Aminoquinolines; Animals; Cell Differentiation; Cytokines; Disease Models, Animal; Fatty Acids, Omega-3; Female; Imiquimod; Inflammation; Inflammation Mediators; Interleukin-17; Interleukin-23; Keratinocytes; Male; Mice; Mice, Transgenic; Organ Size; Protective Agents; Psoriasis; Spleen; Th17 Cells | 2014 |
Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Female; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Langerhans Cells; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; NAV1.8 Voltage-Gated Sodium Channel; Nociceptors; Psoriasis; Sensory Receptor Cells; Skin; T-Lymphocytes; TRPV Cation Channels | 2014 |
TLR-induced cytokines promote effective proinflammatory natural Th17 cell responses.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cytokines; Imiquimod; Inflammation; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Nuclear Receptor Subfamily 1, Group F, Member 3; Promyelocytic Leukemia Zinc Finger Protein; Psoriasis; Th17 Cells; Toll-Like Receptor 4 | 2014 |
Skin-penetrating methotrexate alleviates imiquimod-induced psoriasiform dermatitis via decreasing IL-17-producing gamma delta T cells.
Topics: Aminoquinolines; Animals; CD11c Antigen; CD4-Positive T-Lymphocytes; Cytokines; Dermatitis; DNA, Complementary; Female; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Methotrexate; Mice; Mice, Inbred BALB C; Peptides; Permeability; Psoriasis; Skin | 2014 |
Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Aryl Hydrocarbon Hydroxylases; Azo Compounds; Basic Helix-Loop-Helix Transcription Factors; Carbazoles; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytokines; Environmental Exposure; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Knockout; Psoriasis; Pyrazoles; Receptors, Aryl Hydrocarbon; Signal Transduction; Skin; Transcription Factors; Up-Regulation | 2014 |
Leukotrienes do not modulate the course of Aldara™-induced psoriasiform dermatitis in mice.
Topics: Aminoquinolines; Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Imiquimod; Leukotrienes; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Leukotriene B4; Signal Transduction; Skin | 2015 |
Aldara®-induced skin inflammation: studies of patients with psoriasis.
Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aminoquinolines; Drug Eruptions; Female; Humans; Imiquimod; Male; Middle Aged; Ointments; Psoriasis | 2015 |
IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.
Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Epidermis; Imiquimod; Interleukin-17; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Real-Time Polymerase Chain Reaction | 2014 |
Aldara-induced psoriasis-like skin inflammation: isolation and characterization of cutaneous dendritic cells and innate lymphocytes.
Topics: Aminoquinolines; Animals; Cell Separation; Cells, Cultured; Cricetinae; Dendritic Cells; Drug Eruptions; Female; Flow Cytometry; Imiquimod; Immunity, Innate; Lymphocytes; Male; Mice; Psoriasis; Rats; Skin | 2014 |
Specific roles for dendritic cell subsets during initiation and progression of psoriasis.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; Bone Marrow Transplantation; Dendritic Cells; Disease Progression; Flow Cytometry; Humans; Imiquimod; Interleukin-10; Interleukin-23; Langerhans Cells; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Proto-Oncogene Proteins c-jun; Psoriasis; Receptors, Interleukin; Signal Transduction; Skin; Transcription Factors | 2014 |
Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Capsaicin; Cell Proliferation; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Drug Stability; Emulsions; Gels; Humans; Imiquimod; Immunohistochemistry; In Vitro Techniques; Inflammation; Keratinocytes; Micelles; Microdialysis; Microscopy, Atomic Force; Nanoparticles; Organ Size; Permeability; Psoriasis; Rats; Rheology; Skin Absorption; Spleen | 2014 |
Deficiency of both L-selectin and ICAM-1 exacerbates imiquimod-induced psoriasis-like skin inflammation through increased infiltration of antigen presenting cells.
Topics: Aminoquinolines; Animals; Antigen-Presenting Cells; Cell Movement; Imiquimod; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-17; L-Selectin; Mice; Mice, Knockout; Psoriasis; Real-Time Polymerase Chain Reaction; Severity of Illness Index; Skin | 2015 |
Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by downregulating inflammation.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cytokines; Female; Glucosides; Imiquimod; Macrophages; Mice, Inbred BALB C; Monoterpenes; Neutrophils; Psoriasis; Skin | 2015 |
Osteopontin deficiency affects imiquimod-induced psoriasis-like murine skin inflammation and lymphocyte distribution in skin, draining lymph nodes and spleen.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Lymphocyte Count; Lymphocytes; Mice; Mice, Knockout; Osteopontin; Psoriasis; Skin; Spleen; Th17 Cells | 2015 |
Changes in mRNA expression precede changes in microRNA expression in lesional psoriatic skin during treatment with adalimumab.
Topics: Adalimumab; Adult; Aged; Aminoquinolines; Animals; Anti-Inflammatory Agents; Case-Control Studies; Down-Regulation; Female; Humans; Imiquimod; Interleukin-8; Irritants; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Middle Aged; Psoriasis; RNA, Messenger | 2015 |
IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.
Topics: Aminoquinolines; Animals; Apoptosis; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Proliferation; Cells, Cultured; Cyclin A; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Enzyme Activation; Epidermal Growth Factor; Humans; Imiquimod; Keratinocytes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Phosphorylation; Psoriasis; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Skin; Tumor Suppressor Protein p53 | 2015 |
Glycyrrhizin ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice and inhibits TNF-α-induced ICAM-1 expression via NF-κB/MAPK in HaCaT cells.
Topics: Aminoquinolines; Animals; Cell Adhesion; Cell Line; Cell Survival; Female; Glycyrrhizic Acid; Humans; Imiquimod; Inflammation; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phosphorylation; Psoriasis; Signal Transduction; Skin Diseases; Tumor Necrosis Factor-alpha; Up-Regulation | 2015 |
SIRT1 Activation Ameliorates Aldara-Induced Psoriasiform Phenotype and Histology in Mice.
Topics: Aminoquinolines; Animals; Biopsy, Needle; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Imiquimod; Immunohistochemistry; Keratinocytes; Mice; Phenotype; Psoriasis; Sensitivity and Specificity; Sirtuin 1; Transcriptional Activation | 2015 |
Obesity exacerbates imiquimod-induced psoriasis-like epidermal hyperplasia and interleukin-17 and interleukin-22 production in mice.
Topics: Aminoquinolines; Animals; Cell Line; Disease Models, Animal; Epidermis; Female; Humans; Hyperplasia; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Keratinocytes; Male; Membrane Glycoproteins; Mice; Mice, Mutant Strains; Obesity; Pancreatitis-Associated Proteins; Phosphatidylinositol 3-Kinases; Proteins; Psoriasis; Toll-Like Receptor 7 | 2015 |
Therapeutic and immunomodulatory effects of glucosamine in combination with low-dose cyclosporine a in a murine model of imiquimod-induced psoriasis.
Topics: Aminoquinolines; Animals; Cyclosporine; Dermatitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucosamine; Imiquimod; Immunomodulation; Mice; Mice, Inbred C57BL; Organ Size; Psoriasis; Spleen; T-Lymphocytes, Regulatory | 2015 |
Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin.
Topics: Aminoquinolines; Animals; Calcium Channels; Chemotaxis, Leukocyte; Disease Models, Animal; HL-60 Cells; Humans; Imiquimod; In Vitro Techniques; Membrane Proteins; Mice; Mice, Knockout; Neoplasm Proteins; Neutrophil Infiltration; Neutrophils; Psoriasis; RNA, Small Interfering; Signal Transduction; Skin; Stromal Interaction Molecule 1 | 2015 |
Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1.
Topics: Aminoquinolines; Animals; Cell Culture Techniques; Cell Movement; Cells, Cultured; Cellular Microenvironment; Collagen Type I; Cyclooxygenase 2; Cytokines; Dendritic Cells; Dermatitis, Contact; Dinoprostone; Enzyme Induction; Fibroblasts; Humans; Imiquimod; Irritants; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Monocytes; Picryl Chloride; Psoriasis; Stromal Cells | 2015 |
Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice.
Topics: Aminoquinolines; Animals; Antibodies, Monoclonal; Calgranulin A; Etanercept; Imiquimod; Immunoglobulin G; Inflammation; Infliximab; Interferon Type I; Interleukin-12 Subunit p40; Interleukin-17; Interleukin-23 Subunit p19; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptor, Interferon alpha-beta; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Skin; Tumor Necrosis Factor-alpha | 2015 |
Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Interleukins; Male; Mice; Psoriasis; Resveratrol; Signal Transduction; Stilbenes | 2015 |
Probing the effects of fish oil on the delivery and inflammation-inducing potential of imiquimod.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Delayed-Action Preparations; Female; Fish Oils; Imiquimod; Inflammation; Mice; Permeability; Psoriasis; Skin; Skin Absorption | 2015 |
Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants.
Topics: Aloe; Aminoquinolines; Animals; Celastrus; Curcuma; Cytokines; Dermatitis, Contact; Drug Evaluation, Preclinical; Gene Expression; Imiquimod; Male; Mice; Plant Extracts; Plant Stems; Plants, Medicinal; Psoriasis; Skin; Tinospora | 2016 |
Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis.
Topics: Aminoquinolines; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Proliferation; Cells, Cultured; Dermatitis; Disease Models, Animal; DNA-Binding Proteins; Down-Regulation; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Psoriasis; RNA Interference; Severity of Illness Index; Signal Transduction; Skin | 2015 |
GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation.
Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells; Dermatitis; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression; Humans; Imiquimod; Interleukin-17; Interleukin-6; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Reverse Transcriptase Polymerase Chain Reaction; Th17 Cells; Transcription Factors | 2015 |
CCN1, a Pro-Inflammatory Factor, Aggravates Psoriasis Skin Lesions by Promoting Keratinocyte Activation.
Topics: Aminoquinolines; Animals; Biopsy, Needle; Cell Proliferation; Cells, Cultured; Cysteine-Rich Protein 61; Disease Models, Animal; Disease Progression; Extracellular Matrix; Female; Humans; Imiquimod; Immunohistochemistry; Inflammation Mediators; Interleukin-23; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Knockout; Psoriasis; Random Allocation; Signal Transduction | 2015 |
Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Kallikreins; Mice, Knockout; Psoriasis | 2015 |
Decreased Expression of Caveolin-1 Contributes to the Pathogenesis of Psoriasiform Dermatitis in Mice.
Topics: Aminoquinolines; Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Blotting, Western; Caveolin 1; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Immunohistochemistry; Keratinocytes; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Psoriasis; Random Allocation; Sampling Studies; Signal Transduction; STAT3 Transcription Factor | 2015 |
Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.
Topics: Aminoquinolines; Animals; Azepines; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukins; Male; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Signal Transduction; Skin; Triazoles | 2015 |
Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells.
Topics: Adiponectin; Adjuvants, Immunologic; Adult; Aminoquinolines; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dermatitis; Female; Humans; Imiquimod; Immunoblotting; Interleukin-17; Interleukin-23; Male; Mice; Middle Aged; Psoriasis; Real-Time Polymerase Chain Reaction; Receptors, Adiponectin; Receptors, Antigen, T-Cell, gamma-delta; Reverse Transcriptase Polymerase Chain Reaction; Skin; Subcutaneous Fat | 2015 |
Suppressive effect of β, β-dimethylacryloyl alkannin on activated dendritic cells in an imiquimod-induced psoriasis mouse model.
Topics: Aminoquinolines; Animals; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Dendritic Cells; Dermatologic Agents; Disease Models, Animal; Humans; Imiquimod; Inflammation Mediators; Lymphocyte Activation; Lymphocytes; Male; Mice, Inbred BALB C; Naphthoquinones; Psoriasis; Severity of Illness Index; Skin; Time Factors | 2015 |
Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.
Topics: Aminoquinolines; Animals; Circadian Rhythm; CLOCK Proteins; Dermatitis; Female; Imiquimod; Interleukin-23; Mice; Mice, Inbred C57BL; Mutation; Period Circadian Proteins; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes | 2015 |
Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs.
Topics: Aminolevulinic Acid; Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Imiquimod; Mice; Psoriasis; Skin; Skin Absorption; Tacrolimus; Tretinoin | 2015 |
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Topics: Aminoquinolines; Animals; Animals, Newborn; Anti-Bacterial Agents; Disease Susceptibility; Drug Interactions; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Mice; Mice, Inbred C57BL; Microbiota; Polymyxin B; Psoriasis; Skin; T-Lymphocytes; Vancomycin | 2015 |
IκBζ is a key driver in the development of psoriasis.
Topics: Aminoquinolines; Animals; Humans; I-kappa B Proteins; Imiquimod; Mice; Psoriasis | 2015 |
Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase on Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice.
Topics: Aminoquinolines; Animals; Cytokines; Dendritic Cells; Disease Models, Animal; Gene Expression; Humans; Hyperplasia; Imiquimod; Inflammation Mediators; Janus Kinases; Lymph Nodes; Lymphocyte Activation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mitogen-Activated Protein Kinases; Mucolipidoses; Neutrophil Infiltration; NF-kappa B; Psoriasis; Reactive Oxygen Species; Severity of Illness Index; Signal Transduction; Skin; Spleen; STAT Transcription Factors; Superoxide Dismutase; T-Lymphocytes; Toll-Like Receptor 7; Transduction, Genetic | 2016 |
Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis.
Topics: Aminoquinolines; Animals; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Macrophages; Mice; Mice, Transgenic; Psoriasis; Skin; Transcriptome | 2015 |
IL-22/STAT3-Induced Increases in SLURP1 Expression within Psoriatic Lesions Exerts Antimicrobial Effects against Staphylococcus aureus.
Topics: Aminoquinolines; Animals; Antigens, Ly; Female; Homeostasis; Humans; Imiquimod; Interleukin-22; Interleukins; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Staphylococcus aureus; STAT3 Transcription Factor; Up-Regulation; Urokinase-Type Plasminogen Activator | 2015 |
Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation.
Topics: Administration, Oral; Aminoquinolines; Animals; Anti-Inflammatory Agents; Antrodia; Autoimmunity; Cell Differentiation; Cells, Cultured; Depression, Chemical; Disease Models, Animal; Drugs, Chinese Herbal; Imiquimod; Interleukin-17; Male; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Phosphorylation; Phytotherapy; Psoriasis; Skin; STAT3 Transcription Factor; Th17 Cells | 2015 |
Percutaneous delivery of α-melanocyte-stimulating hormone for the treatment of imiquimod-induced psoriasis.
Topics: Administration, Cutaneous; alpha-MSH; Aminoquinolines; Animals; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Ethylene Glycols; Gels; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Microdialysis; Psoriasis; Rats; Rats, Sprague-Dawley; Skin Absorption | 2016 |
Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice.
Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aminoquinolines; Animals; Biomarkers; Calgranulin A; Drug Eruptions; Imiquimod; Interleukins; Intracellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Mice, Knockout; Ointments; Protein Serine-Threonine Kinases; Psoriasis; RNA, Messenger; Tumor Necrosis Factor-alpha | 2016 |
Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis.
Topics: Aminoquinolines; Animals; Cell Transplantation; CHO Cells; Cricetulus; Disease Models, Animal; Female; Gene Expression Regulation; Genetic Engineering; Genetic Therapy; HEK293 Cells; HeLa Cells; Humans; Imiquimod; Inflammation Mediators; Interleukin-10; Interleukin-22; Interleukin-4; Interleukins; Logic; Mice, Inbred C57BL; Psoriasis; Reproducibility of Results; Signal Transduction; Skin; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 2015 |
IMQ Induced K14-VEGF Mouse: A Stable and Long-Term Mouse Model of Psoriasis-Like Inflammation.
Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Drug Eruptions; Imiquimod; Mice, Inbred Strains; Mice, Transgenic; Otitis; Psoriasis; Vascular Endothelial Growth Factor A | 2015 |
Distinct expression of interleukin (IL)-36α, β and γ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease.
Topics: Aminoquinolines; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Caco-2 Cells; Cell Line; Crohn Disease; Dendritic Cells; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Imiquimod; Inflammation; Interleukin-1; Interleukins; Intestinal Mucosa; Keratinocytes; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Plasma Cells; Psoriasis; RNA, Messenger; Skin; Synovial Membrane; Th17 Cells | 2016 |
Lipocalin-2 exacerbates psoriasiform skin inflammation by augmenting T-helper 17 response.
Topics: Aminoquinolines; Animals; Antimicrobial Cationic Peptides; beta-Defensins; Cells, Cultured; Chemokine CCL20; Female; Humans; Imiquimod; Keratinocytes; Lipocalin-2; Mice, Inbred BALB C; Psoriasis; Skin; Th1 Cells; Th17 Cells | 2016 |
Imiquimod Increases Cutaneous VEGF Expression in Imiquimod-induced Psoriatic Mouse Model.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Psoriasis; Skin; Vascular Endothelial Growth Factor A | 2016 |
Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion.
Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cytokines; Gene Expression Regulation; Glucosides; Imiquimod; Keratinocytes; Mice; Monoterpenes; Nuclear Receptor Subfamily 1, Group F, Member 3; Phosphorylation; Psoriasis; RNA, Messenger; Skin; STAT3 Transcription Factor; Th17 Cells | 2016 |
Immunosuppressive effect of adipose-derived stromal cells on imiquimod-induced psoriasis in mice.
Topics: Adipose Tissue; Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Immune Tolerance; Inflammation Mediators; Mice; Psoriasis; Signal Transduction; Skin; Stromal Cells; Time Factors | 2016 |
Trem-1 is not crucial in psoriasiform imiquimod-induced skin inflammation in mice.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Male; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Triggering Receptor Expressed on Myeloid Cells-1 | 2016 |
Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cell Proliferation; Flavonols; Imiquimod; Immunologic Factors; Interleukin-17; Janus Kinase 3; Keratinocytes; Male; Mice, Inbred BALB C; Psoriasis; Signal Transduction; Skin; STAT3 Transcription Factor; Th17 Cells | 2016 |
Topical imiquimod yields systemic effects due to unintended oral uptake.
Topics: Administration, Oral; Administration, Topical; Aminoquinolines; Animals; Disease Models, Animal; Gastrointestinal Tract; Imiquimod; Interferon Type I; Mice; Phenotype; Psoriasis; Skin Diseases | 2016 |
Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; B7-H1 Antigen; Humans; Imiquimod; Inflammation; Interleukin-17; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Psoriasis; Recombinant Proteins; Skin; T-Lymphocyte Subsets | 2016 |
Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in Human Psoriasis and Imiquimod-induced Murine Psoriasiform Dermatitis Model.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Fatty Acid-Binding Proteins; Imiquimod; Male; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Psoriasis; TOR Serine-Threonine Kinases; Up-Regulation | 2016 |
Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models.
Topics: Aminoquinolines; Animals; Cell Death; Cell Line; Cell Survival; Digitoxigenin; Disease Models, Animal; Female; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Necrosis; Oxidative Stress; Psoriasis; Tetradecanoylphorbol Acetate | 2016 |
Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice'.
Topics: Aminoquinolines; Animals; Imiquimod; Inflammation; Mice; Psoriasis; Tumor Necrosis Factor-alpha | 2016 |
Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Drug Evaluation, Preclinical; Female; Gene Expression; Genes, Reporter; Humans; Imiquimod; Immunologic Factors; Interleukin-17; Jurkat Cells; Luciferases; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Permeability; Primary Cell Culture; Psoriasis; Skin; Small Molecule Libraries; Th17 Cells; Translational Research, Biomedical | 2016 |
Oral administration of acarbose ameliorates imiquimod-induced psoriasis-like dermatitis in a mouse model.
Topics: Acarbose; Administration, Oral; Aminoquinolines; Animals; Cell Movement; Cytokines; Dermatitis, Contact; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Neutrophils; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; T-Lymphocytes, Regulatory; Th17 Cells | 2016 |
Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling.
Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Cytokines; Disease Models, Animal; Enzyme Activation; Epidermal Cells; Epidermis; Female; Gene Expression; Gene Expression Regulation; Heme Oxygenase-1; Imiquimod; Keratinocytes; Mice; Models, Biological; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Psoriasis; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Th17 Cells | 2016 |
Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine.
Topics: Aminoquinolines; Animals; Cell Movement; Cytokines; Disease Models, Animal; Female; Forkhead Transcription Factors; Humans; Imiquimod; Inflammation; Interleukin-2 Receptor alpha Subunit; Methylhistamines; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Skin; T-Lymphocytes, Regulatory; Th1 Cells | 2016 |
Therapeutic Effects of Erythroid Differentiation Regulator 1 on Imiquimod-Induced Psoriasis-Like Skin Inflammation.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Calgranulin A; Disease Models, Animal; Gene Expression Regulation; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Membrane Proteins; Mice; Psoriasis; Recombinant Proteins; Th17 Cells; Tumor Suppressor Proteins | 2016 |
CX3CR1 deficiency attenuates imiquimod-induced psoriasis-like skin inflammation with decreased M1 macrophages.
Topics: Aminoquinolines; Animals; Cell Count; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Interleukins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Chemokine; Skin; Tumor Necrosis Factor-alpha | 2016 |
Increased Lipocalin-2 Contributes to the Pathogenesis of Psoriasis by Modulating Neutrophil Chemotaxis and Cytokine Secretion.
Topics: Adolescent; Adult; Aminoquinolines; Animals; Antibodies, Monoclonal; Biopsy; Cell Differentiation; Chemotaxis; Cytokines; Epidermis; Female; HL-60 Cells; Humans; Imiquimod; Inflammation; Lipocalin-2; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Middle Aged; Neutrophils; Psoriasis; Recombinant Proteins; RNA, Small Interfering; Young Adult | 2016 |
IL-6 Signaling in Myelomonocytic Cells Is Not Crucial for the Development of IMQ-Induced Psoriasis.
Topics: Aminoquinolines; Animals; Bone Marrow; Cell Compartmentation; Gene Deletion; Humans; Imiquimod; Interleukin-6; Mice; Monocytes; Psoriasis; Receptors, Interleukin-6; Signal Transduction; Spleen; T-Lymphocytes | 2016 |
AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model.
Topics: Aminoquinolines; Animals; Cell Proliferation; Chemotaxis; Disease Models, Animal; Imiquimod; Immunity, Innate; Interleukin-22; Interleukins; Mice; Mice, Knockout; Psoriasis; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Aryl Hydrocarbon; T-Lymphocyte Subsets; Th17 Cells | 2016 |
Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice': reply from authors.
Topics: Aminoquinolines; Animals; Imiquimod; Inflammation; Mice; Psoriasis; Tumor Necrosis Factor-alpha | 2016 |
Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation.
Topics: Aminoquinolines; Animals; Biomarkers; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Epidermis; Filaggrin Proteins; Gene Expression; Gene Expression Regulation; Imiquimod; Keratinocytes; Male; Mice; Mice, Knockout; Oncostatin M; Phenotype; Psoriasis; Skin | 2016 |
Vascular endothelial growth factor partially induces pruritus via epidermal hyperinnervation in imiquimod-induced psoriasiform dermatitis in mice.
Topics: Aminoquinolines; Animals; Axitinib; Dermatitis, Atopic; Disease Models, Animal; Epidermis; Humans; Imidazoles; Imiquimod; Indazoles; Mice; Pruritus; Psoriasis; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A | 2016 |
MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A.
Topics: Aminoquinolines; Animals; Antigens, Differentiation, T-Lymphocyte; Biopsy; Coculture Techniques; Epidermis; Gene Silencing; Humans; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Phosphorylation; Psoriasis; Receptors, Interleukin-17; Ribonucleases; Skin; STAT3 Transcription Factor; Transcription Factors; Tumor Necrosis Factor-alpha | 2016 |
Original Research: Different imiquimod creams resulting in differential effects for imiquimod-induced psoriatic mouse models.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Dermatologic Agents; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Cream; Treatment Outcome | 2016 |
Influence of different types of contact hypersensitivity on imiquimod-induced psoriasis-like inflammation in mice.
Topics: Aminoquinolines; Animals; Biomarkers; Cytokines; Dermatitis, Contact; Disease Models, Animal; Female; Gene Expression; Imiquimod; Mice; Psoriasis; Skin; Th1 Cells; Th17 Cells; Th2 Cells | 2016 |
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Topics: Aminoquinolines; Animals; B-Lymphocytes; Disease Models, Animal; Imiquimod; Interleukin-10; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Psoriasis; Signal Transduction | 2016 |
Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88.
Topics: Aminoquinolines; Andrographis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Diterpenes; Drugs, Chinese Herbal; Imiquimod; Interleukin-1beta; Interleukin-23; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Proteolysis; Psoriasis; Skin; TNF Receptor-Associated Factor 6 | 2016 |
The genetic difference between C57Bl/6J and C57Bl/6N mice significantly impacts Aldara™-induced psoriasiform dermatitis.
Topics: Aminoquinolines; Animals; Dermatitis; Disease Models, Animal; Imiquimod; Mice, Inbred C57BL; Psoriasis; Skin; Species Specificity | 2017 |
Collagen-induced arthritis and imiquimod-induced psoriasis develop independently of interleukin-33.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Resorption; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Imiquimod; Interleukin-33; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis | 2016 |
Paeoniflorin suppresses inflammatory response in imiquimod-induced psoriasis-like mice and peripheral blood mononuclear cells (PBMCs) from psoriasis patients.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Glucosides; Humans; Imiquimod; Inflammation Mediators; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred BALB C; Monoterpenes; Psoriasis; Random Allocation | 2016 |
The Exonuclease Trex2 Shapes Psoriatic Phenotype.
Topics: Aminoquinolines; Animals; Apoptosis; Biopsy, Needle; Case-Control Studies; Cell Survival; Cells, Cultured; Disease Models, Animal; Exodeoxyribonucleases; Gene Expression Regulation; Humans; Imiquimod; Immunohistochemistry; Keratinocytes; Mice; Mice, Knockout; Phenotype; Prognosis; Psoriasis; Severity of Illness Index; Up-Regulation | 2016 |
Reducing Flightless I expression decreases severity of psoriasis in an imiquimod-induced murine model of psoriasiform dermatitis.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Carrier Proteins; Cytoskeletal Proteins; Dermatitis; Disease Models, Animal; Drug Eruptions; Female; Humans; Imiquimod; Irritants; Male; Mice, Inbred BALB C; Microfilament Proteins; Middle Aged; Psoriasis; RNA, Messenger; Toll-Like Receptor 4; Trans-Activators | 2017 |
Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Cell Cycle; Cell Proliferation; Disease Models, Animal; Hair Follicle; Imiquimod; Mice; Mice, Inbred C57BL; Psoriasis; Stem Cells | 2016 |
Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.
Topics: Administration, Topical; Aminoquinolines; Animals; Anthocyanins; Antioxidants; Binding Sites; Biopsy; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Imiquimod; Immunomodulation; Inflammation Mediators; Mice; Models, Molecular; Molecular Conformation; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Psoriasis; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Skin; TOR Serine-Threonine Kinases | 2017 |
Multi-glycoside of Tripterygium wilfordii Hook. f. ameliorates imiquimod-induced skin lesions through a STAT3-dependent mechanism involving the inhibition of Th17-mediated inflammatory responses.
Topics: Aminoquinolines; Animals; CD4-Positive T-Lymphocytes; Cytokines; Gene Expression; Glycosides; Imiquimod; Immunohistochemistry; Inflammation; Inflammation Mediators; Interleukin-17; Mice, Inbred BALB C; Phosphorylation; Phytotherapy; Protective Agents; Psoriasis; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Diseases; STAT3 Transcription Factor; T-Lymphocytes, Regulatory; Th17 Cells; Tripterygium | 2016 |
Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response.
Topics: Actinobacteria; Aminoquinolines; Animals; Anti-Bacterial Agents; Clostridiales; Disease Models, Animal; Female; Gastrointestinal Microbiome; Gene Expression; Germ-Free Life; Humans; Imiquimod; Interleukin-17; Lactobacillales; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; Species Specificity; Th17 Cells | 2016 |
Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod-induced psoriasis-like skin inflammation in mice.
Topics: Aminoquinolines; Animals; Anti-Bacterial Agents; Azithromycin; Cell Proliferation; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Humans; Imiquimod; Keratinocytes; Leukocytes, Mononuclear; Lysosomes; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Psoriasis; Signal Transduction; Skin; Spleen; Th17 Cells; Toll-Like Receptor 7 | 2016 |
Increased βTrCP are associated with imiquimod-induced psoriasis-like skin inflammation in mice via NF-κB signaling pathway.
Topics: Aminoquinolines; Animals; beta-Transducin Repeat-Containing Proteins; Cell Line; Cells, Cultured; Humans; Imiquimod; Intercellular Adhesion Molecule-1; Keratinocytes; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2016 |
Leptin deficiency in mice counteracts imiquimod (IMQ)-induced psoriasis-like skin inflammation while leptin stimulation induces inflammation in human keratinocytes.
Topics: Aminoquinolines; Animals; Cell Proliferation; Cells, Cultured; Chemokine CCL20; Chemokine CXCL1; Gene Expression; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukin-6; Interleukins; Keratinocytes; Leptin; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Psoriasis; RNA, Messenger | 2017 |
Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model.
Topics: Acanthosis Nigricans; Aminoquinolines; Animals; Cell Differentiation; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Glucosides; Humans; Imiquimod; Immunohistochemistry; Inflammation; Interleukin-22; Interleukins; Keratinocytes; Lipids; Luteolin; Mice, Inbred C57BL; Oxidation-Reduction; Phenotype; Protein Transport; Psoriasis; Signal Transduction; STAT3 Transcription Factor | 2016 |
MAD ointment ameliorates Imiquimod-induced psoriasiform dermatitis by inhibiting the IL-23/IL-17 axis in mice.
Topics: Aminoquinolines; Animals; Cell Proliferation; Centella; Dermatitis; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Ointments; Psoriasis; Signal Transduction; Skin; Th17 Cells; Triterpenes | 2016 |
MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis.
Topics: Adult; Aminoquinolines; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Imiquimod; Interleukin-17; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Neutrophil Infiltration; Polymorphism, Single Nucleotide; Psoriasis; Skin; Sweden | 2017 |
Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2.
Topics: Aminoquinolines; Animals; Biopsy, Needle; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Immunohistochemistry; Inflammation; Keratinocytes; Mice; Mice, Inbred C57BL; Phenotype; Polymerase Chain Reaction; Psoriasis; Random Allocation; Receptors, Chemokine; Reference Values; Statistics, Nonparametric; Up-Regulation | 2017 |
miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice.
Topics: Aminoquinolines; Animals; Down-Regulation; Imiquimod; Keratinocytes; Mice; Mice, Knockout; MicroRNAs; Psoriasis; T-Lymphocytes; Up-Regulation | 2017 |
Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.
Topics: Aminoquinolines; Animals; Antioxidants; Body Weight; Catechin; Cytokines; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Spleen | 2016 |
A PPARδ-selective antagonist ameliorates IMQ-induced psoriasis-like inflammation in mice.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Benzamides; Cytokines; Imiquimod; Mice; PPAR delta; Psoriasis; RNA, Messenger; Skin; Sulfones | 2016 |
Protective effects of agonistic anti-4-1BB antibody on the development of imiquimod-induced psoriasis-like dermatitis in mice.
Topics: Aminoquinolines; Animals; Antibodies, Monoclonal; Biopsy; Cytokines; Disease Models, Animal; Female; Imiquimod; Inflammation Mediators; Mice; Phenotype; Protective Agents; Psoriasis; Skin; Splenomegaly; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Necrosis Factor Receptor Superfamily, Member 9 | 2016 |
Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism.
Topics: Aminoquinolines; Animals; Dermatitis; Epidermis; Imiquimod; Kallikreins; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptor, PAR-2 | 2017 |
Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Biological Availability; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Hydrogels; Imiquimod; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Polymers; Psoriasis; Skin; Skin Absorption; Solubility; Tacrolimus | 2016 |
Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Disease Susceptibility; DNA-Binding Proteins; Female; Gene Expression Profiling; Imiquimod; Interleukin-17; Interleukin-23; Keratinocytes; Lymphocytes; Male; Mice; Mice, Knockout; Psoriasis; Transcriptome | 2016 |
IL-22 binding protein regulates murine skin inflammation.
Topics: Aminoquinolines; Animals; Case-Control Studies; Dermatitis, Contact; Female; Humans; Imiquimod; Male; Mice; Oxazolone; Psoriasis; Receptors, Interleukin | 2017 |
Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Chemistry, Pharmaceutical; Curcumin; Delayed-Action Preparations; Dermatologic Agents; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Gels; Imiquimod; Immunosuppressive Agents; Lipids; Male; Mice; Mice, Inbred BALB C; Particle Size; Psoriasis; Tacrolimus; Tissue Distribution | 2016 |
Proinflammatory effect of high-mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development.
Topics: Aminoquinolines; Animals; Autocrine Communication; Cell Proliferation; Disease Models, Animal; HMGB1 Protein; Humans; Imiquimod; Inflammasomes; Interleukin-17; Interleukin-18; Keratinocytes; Mice, Inbred BALB C; Psoriasis; Signal Transduction | 2017 |
IL-12 protects from psoriasiform skin inflammation.
Topics: Aminoquinolines; Animals; Female; Humans; Imiquimod; Inflammation; Interleukin-12; Interleukin-23; Keratinocytes; Mice, Inbred C57BL; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin | 2016 |
Polyinosinic-polycytidylic acid (poly(I:C)) attenuates imiquimod-induced skin inflammation in mice by increasing cutaneous PD-L1 expression.
Topics: Aminoquinolines; Animals; B7-H1 Antigen; Cell Line, Transformed; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Keratinocytes; Mice; Poly I-C; Psoriasis; Toll-Like Receptor 3 | 2017 |
Overexpression of Glucocorticoid-induced Leucine Zipper (GILZ) increases susceptibility to Imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1.
Topics: Aminoquinolines; Animals; Calgranulin A; Cytokines; Dendritic Cells; Gene Expression Regulation; Gene Knock-In Techniques; Imiquimod; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Neutrophils; Psoriasis; Recombinant Proteins; Signal Transduction; Skin; Smad2 Protein; Smad3 Protein; Specific Pathogen-Free Organisms; T-Lymphocytes; Transcription Factors; Transforming Growth Factor beta1 | 2016 |
Decreased expression of IL-27 in moderate-to-severe psoriasis and its anti-inflammation role in imiquimod-induced psoriasis-like mouse model.
Topics: Aminoquinolines; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Imiquimod; Immunotherapy; Injections, Subcutaneous; Interferon-gamma; Interleukin-10; Interleukin-17; Interleukins; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Psoriasis; Receptors, Interleukin; Recombinant Proteins; RNA, Messenger; Severity of Illness Index; Skin; Th1 Cells; Th17 Cells | 2017 |
Involvement of high mobility group box-1 in imiquimod-induced psoriasis-like mice model.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Glycyrrhizic Acid; HMGB1 Protein; Imiquimod; Phytotherapy; Plant Extracts; Psoriasis | 2017 |
TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model.
Topics: Aminoquinolines; Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Imiquimod; Mice, Knockout; Psoriasis; Ribonucleoproteins | 2017 |
The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal.
Topics: Aminoquinolines; Animals; Dermatitis; Dermatology; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Psoriasis; Research Design | 2017 |
Activation of Langerhans cells promotes the inflammation in imiquimod-induced psoriasis-like dermatitis.
Topics: Aminoquinolines; Animals; Antigens, CD; Antigens, Surface; Cytokines; Disease Models, Animal; Epidermal Cells; Epidermis; Flow Cytometry; Imiquimod; Langerhans Cells; Lectins, C-Type; Lymph Nodes; Mannose-Binding Lectins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Psoriasis; Tumor Necrosis Factor-alpha | 2017 |
Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Dendritic Cells; Drug Eruptions; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Interleukin-23; Langerhans Cells; Major Histocompatibility Complex; Membrane Proteins; Mice; Mice, Knockout; Monocytes; Psoriasis; Skin | 2016 |
Anti-psoriatic potential of Solanum xanthocarpum stem in Imiquimod-induced psoriatic mice model.
Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Imiquimod; Male; Mice; Plant Extracts; Plant Stems; Psoriasis; Solanum | 2017 |
Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Body Temperature; Disease Models, Animal; Female; Imiquimod; Inflammation; Interleukin-1; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Pain Measurement; Psoriasis; Receptors, Interleukin-1 Type I; Sex Factors; Skin | 2016 |
Surgical Denervation in the Imiquimod-Induced Psoriasiform Mouse Model.
Topics: Aminoquinolines; Animals; Denervation; Dermatologic Surgical Procedures; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Imiquimod; Interleukin-17; Interleukin-23; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; T-Lymphocytes; Toll-Like Receptor 7 | 2017 |
Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in Mice.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Female; Garcinia mangostana; Humans; Imiquimod; Interleukin-2; Interleukin-23; Mice; Mice, Inbred C57BL; Plant Extracts; Psoriasis; Skin; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Necrosis Factor-alpha | 2017 |
BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis.
Topics: Aminoquinolines; Animals; Apoptosis; Cytokines; Dermatologic Agents; Drug Eruptions; Drug Evaluation, Preclinical; Imiquimod; Inflammasomes; Male; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nitriles; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; RNA, Messenger; STAT3 Transcription Factor; Sulfones | 2017 |
Tonsil-derived mesenchymal stem cells (T-MSCs) prevent Th17-mediated autoimmune response via regulation of the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway.
Topics: Animals; Autoimmunity; B7-H1 Antigen; Cell Differentiation; Culture Media, Conditioned; Female; Gene Expression Regulation; Imiquimod; Inflammation; Interleukin-17; Lymph Nodes; Mesenchymal Stem Cells; Mice, Inbred C57BL; Palatine Tonsil; Psoriasis; Side-Population Cells; Signal Transduction; Skin; Th17 Cells | 2018 |
Ccr6 Is Dispensable for the Development of Skin Lesions Induced by Imiquimod despite its Effect on Epidermal Homing of IL-22-Producing Cells.
Topics: Aminoquinolines; Animals; beta-Galactosidase; Cells, Cultured; Disease Models, Animal; Epidermis; Gene Knock-In Techniques; Homeodomain Proteins; Imiquimod; Interleukin-22; Interleukins; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, CCR6; T-Lymphocyte Subsets | 2017 |
GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model.
Topics: Acetamides; Acetates; Aminoquinolines; Animals; Disease Models, Animal; Dual Oxidases; Epidermis; Imiquimod; Inflammation; Interleukin-6; Male; Mice, Inbred BALB C; Models, Biological; Psoriasis; Receptors, G-Protein-Coupled; Signal Transduction; Th17 Cells; Up-Regulation | 2017 |
Effects of Topical Application of Betamethasone on Imiquimod-induced Psoriasis-like Skin Inflammation in Mice.
Topics: Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Betamethasone; Cytokines; Disease Models, Animal; Female; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Psoriasis; RNA, Messenger; Skin; Th1 Cells; Th17 Cells | 2016 |
Psoriasis-like inflammation leads to renal dysfunction via upregulation of NADPH oxidases and inducible nitric oxide synthase.
Topics: Acetylcysteine; Aminoquinolines; Animals; Antioxidants; Buthionine Sulfoximine; Disease Models, Animal; Humans; Imiquimod; Inflammation; Kidney; Kidney Diseases; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Psoriasis | 2017 |
Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.
Topics: Aminoquinolines; Animals; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Imiquimod; Interleukin-17; Male; Mice; Mice, Inbred Strains; Psoriasis; Sequence Analysis, RNA; Sex Factors; Skin; Species Specificity | 2017 |
Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.
Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Dermatitis, Contact; Disease Models, Animal; Humans; Imiquimod; Inflammation Mediators; Interleukin-17; Interleukin-23; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Interleukin-17 | 2009 |
Psoriasis.
Topics: Aminoquinolines; Humans; Imiquimod; Interferon Inducers; Psoriasis | 2009 |
Imiquimod cream 5% for the treatment of arsenic-induced cutaneous neoplasms.
Topics: Administration, Cutaneous; Aged, 80 and over; Aminoquinolines; Antineoplastic Agents; Arsenic; Carcinoma, Squamous Cell; Follow-Up Studies; Humans; Imiquimod; Keratosis; Male; Neoplasm Recurrence, Local; Psoriasis; Skin Neoplasms | 2010 |
Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.
Topics: Adolescent; Adult; Aged; Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Epidermis; Gene Expression Profiling; Genomics; Humans; Imiquimod; Keratinocytes; Leukocytes; Mice; Middle Aged; Mitosis; Phenotype; Psoriasis; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Transcription, Genetic; Young Adult | 2011 |
[Oral acitretin and topical imiquimod as neoadjuvant treatment for giant basal cell carcinoma].
Topics: Acitretin; Administration, Cutaneous; Administration, Oral; Aged; Aminoquinolines; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Basal Cell; Combined Modality Therapy; Facial Neoplasms; Female; Humans; Imiquimod; Neoadjuvant Therapy; Psoriasis; Remission Induction; Skin Neoplasms; Skin Ulcer; Thoracic Neoplasms | 2012 |
Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cell Differentiation; Colitis; Dextran Sulfate; Drug Delivery Systems; Hypersensitivity, Delayed; Imiquimod; Interleukin-12; Interleukin-23; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; TYK2 Kinase | 2011 |
Anti-inflammatory and immunomodulatory effects of bortezomib in various in vivo models.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Anti-Inflammatory Agents; Boronic Acids; Bortezomib; Dinitrofluorobenzene; Disease Models, Animal; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Female; Hypersensitivity, Delayed; Imiquimod; Immunologic Factors; Irritants; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Peritonitis; Psoriasis; Pyrazines; Random Allocation; Temperature; Thioglycolates | 2011 |
Skin permeating nanogel for the cutaneous co-delivery of two anti-inflammatory drugs.
Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Delivery Systems; Humans; Hypromellose Derivatives; Imiquimod; Immunohistochemistry; Inflammation; Methylcellulose; Mice; Mice, Inbred C57BL; Nanogels; Nanoparticles; Particle Size; Permeability; Polyethylene Glycols; Polyethyleneimine; Psoriasis; Rheology; Skin; Surface Properties; Viscosity | 2012 |
IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antigens, Differentiation; Chemokine CCL3; Dermatitis; Disease Models, Animal; Gene Expression Regulation; Imiquimod; Immunity, Innate; Interleukin-22; Interleukins; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; T-Lymphocytes | 2012 |
Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Macrophages; Mice; Mice, Knockout; Neutrophils; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; T-Lymphocytes | 2012 |
Assessment of an imiquimod-induced psoriatic mouse model in relation to oxidative stress.
Topics: Aminoquinolines; Animals; Antioxidants; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Oxidative Stress; Peroxidase; Psoriasis; Reactive Oxygen Species; Skin; Superoxide Dismutase; Superoxide Dismutase-1 | 2012 |
An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Disease Models, Animal; Female; Imiquimod; Interleukin-17; Interleukin-22; Interleukin-6; Interleukins; Macrophages; Mice; Mice, Knockout; Neutrophil Infiltration; Psoriasis; Receptors, Interleukin-17; Signal Transduction; Skin | 2013 |
IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cells, Cultured; Chemokines; Dendritic Cells; Disease Models, Animal; Epidermal Cells; Epidermis; Female; Humans; Imiquimod; Interleukin-23 Subunit p19; Interleukins; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Psoriasis; RNA, Messenger; Th1 Cells; Tumor Necrosis Factor-alpha | 2013 |
Caspase-14-deficient mice are more prone to the development of parakeratosis.
Topics: Aminoquinolines; Animals; Caspases; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Genetic Predisposition to Disease; Imiquimod; Keratinocytes; Mice; Mice, Knockout; Parakeratosis; Psoriasis | 2013 |
Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis.
Topics: Aminoquinolines; Animals; Class I Phosphatidylinositol 3-Kinases; Class Ib Phosphatidylinositol 3-Kinase; Dermatitis; Disease Models, Animal; Female; Gene Knock-In Techniques; Humans; Imiquimod; Interleukin-17; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Psoriasis; T-Lymphocyte Subsets | 2012 |
Psoriasis induced by topical imiquimod.
Topics: Administration, Cutaneous; Aminoquinolines; Antineoplastic Agents; Carcinoma, Basal Cell; Female; Humans; Imiquimod; Interferon Inducers; Middle Aged; Psoriasis; Skin; Skin Neoplasms | 2004 |
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.
Topics: Administration, Topical; Aminoquinolines; Biopsy; Dendritic Cells; Diagnostic Errors; Fluorescent Antibody Technique; Humans; Imiquimod; Immunohistochemistry; Interferon Inducers; Male; Membrane Glycoproteins; Middle Aged; Plasma Cells; Psoriasis; Receptors, Cell Surface; Skin; Stem Cells; Toll-Like Receptor 7; Toll-Like Receptors | 2004 |
Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomas.
Topics: Administration, Topical; Aminoquinolines; Antineoplastic Agents; Carcinoma, Basal Cell; Drug Eruptions; Female; Humans; Imiquimod; Middle Aged; Psoriasis; Skin Neoplasms | 2006 |
Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod.
Topics: Administration, Cutaneous; Aged; Aminoquinolines; Antineoplastic Agents; Drug Eruptions; Humans; Imiquimod; Keratosis; Male; Ointments; Psoriasis; Scalp Dermatoses | 2006 |