Page last updated: 2024-08-24

imiquimod and Psoriasis

imiquimod has been researched along with Psoriasis in 709 studies

Research

Studies (709)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (0.99)29.6817
2010's336 (47.39)24.3611
2020's366 (51.62)2.80

Authors

AuthorsStudies
Chen, C; Dai, L; Liu, J; Liu, L; Pan, Y; Sui, Q; Sun, H; Sun, L; Wen, X; You, Y; Yuan, H1
Abbas, H; Elgewelly, MA; Elmasry, SM; Sayed, NSE1
Kong, L; Li, M; Lv, W; Meng, S; Qiao, H; Song, C; Sun, Y; Wang, X; Yang, C; Zhu, Y1
Chen, S; Chen, X; Lin, Z; Xi, L; Zheng, Y; Zhou, Q1
Amento, E; Kang, GJ; Kaur, M; Mechanic, J; Ravikumar, P; Welihinda, A; Yadav, S1
Gao, J; Li, X; Ma, X; Miao, Y; Wei, W; Xi, B; Yang, C; Zhang, J; Zhou, H1
Egawa, S; Ito, M; Kamata, M; Mizukawa, I; Shimizu, T; Tada, Y; Takeshima, R; Uchida, H; Watanabe, A1
Chen, C; Duan, Q; Liu, M; Shao, Y; Sun, Q; Wang, M; Wang, Y; Zhang, M; Zheng, Y1
Asahina, R; Chow, Z; Dainichi, T; Egawa, G; Ishida, Y; Kabashima, K; Kitoh, A; Miyake, T; Nomura, T; Okuno, T; Otsuka, M; Yokomizo, T1
Chitkara, D; Mittal, A; Pukale, SS1
Chen, S; Chen, X; Cheng, H; Hua, C; Lai, L; Song, Y; Wu, X; Xu, Y; Zhu, J1
Abdollahifar, MA; Dehpour, AR; Haddadi, NS; Hedayatyanfard, K; Kazemi, K; Shayan, M; Shokrian Zeini, M; Solaimanian, S1
Hu, Z; Huang, N; Li, J; Liu, X; Ma, T; Wang, Z; Wei, X; Wu, W; Zhang, J; Zhen, H; Zhou, H1
Bassaganya-Riera, J; Chauhan, J; Hontecillas, R; Leber, A; Maturavongsadit, P; Tubau-Juni, N1
Bai, Q; Chan, CKW; Choi, CHJ; Choi, PC; Han, R; Ho, LWC; Lee, LKC1
Alalaiwe, A; Chang, ZY; Chen, CY; Chuang, SY; Fang, JY; Sung, JT1
Baek, JO; Jun, HS; Kim, D; Kim, HJ; Roh, JY1
Choi, YA; Jang, YH; Jeong, GS; Kang, J; Kim, N; Kim, SH; Lee, S1
Kang, J; Khang, D; Kim, N; Kim, SH; Kwon, TK; Lee, S1
Chen, C; Chen, X; Chen, Z; Dou, X; Huang, C; Huang, H; Huang, X; Jian, X; Jiang, B; Li, Z; Liu, X; Ren, X; Shen, C; Yang, L; Yu, B; Zhong, W1
Vinardell, MP1
Albanesi, C; Madonna, S; Mercurio, L; Morelli, M; Pallotta, S; Scaglione, GL; Scarponi, C1
Fang, H; Li, C; Lu, Z; Ma, L; Shao, S; Wang, G; Xue, K1
Abdellatif, AAH; Abdulmonem, WA; Al Rugaie, O; Alhumaydhi, FA; Aljasir, M; Aljohani, ASM; AlKhowailed, MS; Alnuqaydan, AM; Alsagaby, SA; Alsuhaibani, SA; Alwashmi, ASS; Babiker, AY; Elsheikh, SY; Hegazy, AMS; Mousa, AM; Seleem, HS; Soliman, KEA; Yosof, MYR1
Iida, K; Ishikawa, J; Iwamoto, T; Iwata, A; Kageyama, T; Makita, S; Nakajima, H; Suto, A; Suzuki, K; Tanaka, S; Yabe, Y; Yokota, M1
Blauvelt, A; Boki, H; Kimura, T; Miyagaki, T; Okochi, H; Sato, S; Suga, H; Sugaya, M1
Jiang, J; Kuai, L; Li, B; Li, X; Liu, T; Luo, Y; Ru, Y; Song, J; Sun, X; Xing, M; Zhang, H1
Bocheńska, K; Gabig-Cimińska, M; Moskot, M1
Cheng, G; Kuang, H; Su, Y; Wang, Q; Wu, L; Zhang, F1
Chen, Y; He, Y; Li, W; Ma, Y; Shangguan, Y; Zhao, Y1
Alalaiwe, A; Chuang, SY; Fang, JY; Huang, TH; Lin, CF; Nguyen, TMH; Wang, PW1
Di, T; Fu, J; Guo, J; Guo, X; Li, P; Liu, Q; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J1
Deng, M; Li, S; Li, X; Luo, S; Su, Y; Tan, S; Tang, G; Wu, R; Zhang, P; Zhang, Q; Zhang, S; Zhang, X; Zhao, M; Zhu, Y1
Chen, D; Gao, J; Guo, W; Jiang, X; Ke, B; Lai, Y; Ma, H; Shao, F; Sun, Y; Wu, Z; Xu, Q; Yan, W; Zhu, Y1
Gangwar, RS; Gudjonsson, JE; Ward, NL1
Chen, Z; Di, T; Li, P; Lv, J; Wang, Y; Xu, J; Yang, H; Zhou, T1
Cao, G; Cao, Z; Liu, Z; Shi, Y; Sun, R; Xu, Q; Yang, N; Zhang, C1
Chen, ZX; Di, TT; Li, P; Liu, Y; Liu, ZR; Meng, YJ; Wang, Y; Zhao, JX1
Bai, J; Bao, L; Cai, X; Jiang, B; Li, Q; Li, X; Lou, F; Song, N; Sun, L; Sun, Y; Tang, S; Wang, B; Wang, H; Wang, Z; Wu, Y; Yin, Q; Yu, B; Zhou, H1
Chen, X; Li, B; Li, HJ; Li, W; Li, X; Liu, L; Lu, Y; Sun, XY; Ze, K; Zhou, YQ1
Alarcón-Riquelme, ME; Castillejo-López, C; Coppard, C; Gómez-Hernández, G; Kumar, R; Luque, MJ; Marañón, C; Martín-Morales, N; Morell, M; O'Valle, F; Pérez-Cózar, F; Varela, N; Wu, YY1
Han, D; Li, F; Lu, S; Meng, L; Mou, K; Wang, B; Xu, J; Zhang, W; Zhao, Y; Zhou, Y; Zhu, W1
Bayik, D; Braley, C; Chandrasekharan, UM; de Windt, N; DiCorleto, PE; Fernandez, AP; Harvey, JE; Hsieh, J; Husni, ME; Jaini, R; Kaur, R; Lee, M; Rai, V; Scheraga, RG1
Chen, J; Dang, E; Fang, H; Li, Q; Ma, J; Pang, B; Qiao, H; Qiao, P; Shao, S; Sun, Z; Wang, G; Wang, L; Xue, K; Yu, C1
Du, JC; Han, X; Liu, XH; Yan, Y; Zhang, F; Zhu, R1
Chen, N; Li, L; Tian, C; Xia, Z; Yang, S; Zhang, G1
Cui, J; Li, W; Sun, H; Zhai, S; Zhang, P; Zhao, Y1
Jun, L; Kun, X; Lu, L; Pin, C; Wei, C; Xiangjin, X; Xiaohong, L; Xin, L; Yunjie, Y; Zhenting, Z1
Choi, MJ; Nguyen, LTH; Shin, HM; Yang, IJ1
Lin, X; Liu, Q; Qian, J; Tang, J; Xie, Q; Xiong, S; Zhou, Z1
Guo, H; Li, M; Liu, H1
Ma, X; Mao, J; Zhang, H; Zhu, J1
Aljuffali, IA; Fang, JY; Huang, JR; Lin, CF; Tseng, CH; Yang, SH1
Cichy, J; Grygier, B; Kapinska-Mrowiecka, M; Kwiecinska, P; Kwitniewski, M; Majchrzak-Gorecka, M; Morytko, A; Porebski, G; Sanecka-Duin, A1
Cheng, H; Du, X; Li, M; Mei, X; Pan, Y; Tian, D; Yang, L; Zhang, D1
Chen, Y; Cui, L; Dai, X; Gu, J; Guo, C; Shi, Y; Xu, H; Yu, Q; Yu, Y; Yu, Z; Zhang, X1
Chung, JH; Jo, SJ; Kim, EJ; Kim, SJ; Kim, TG; Lee, Y; Ohn, J; Suh, JH1
Chen, Y; Chen, Z; Guo, C; Hu, Y; Shi, Y; Wang, Y; Xu, P; Yu, Q; Yu, Z; Zhang, X; Zhao, Z; Zhou, X1
Agostini, SBN; Alves, CO; Bernardes, MTCP; Carvalho, FC; da Silva, LP; Gonçalves, RV; Novaes, RD; Pereira, GR1
Chen, S; Chen, X; He, T; Islam, MS; Liao, P; Lin, Z; Xi, L; Yang, Y; Zheng, Y1
Cha, X; Chen, Y; Lai, B; Tao, T; Wang, J; Wang, W; Xiao, W1
Rasool, M; Srikanth, M1
Cheng, LY; Deng, Y; Feng, XY; Guo, DJ; Guo, WJ; Hua, L; Li, FL; Liu, X; Wang, Y; Xi, RF; Ze, K; Zhu, JY; Zhu, SJ1
Dang, N; Fan, H; Huang, S; Li, X; Liu, N; Ma, G; Qin, L; Wang, J; Yang, T; Zhang, P1
Chen, ZX; Di, TT; Feng, F; Hu, XQ; Li, P; Meng, YJ; Qi, C; Wang, Y; Wang, YZ; Zhao, JX1
Fang, X; Li, W; Ling, S; Liu, X; Luo, Y; Wang, A; Xu, B; Yao, X; Zhang, S; Zhou, Y; Zong, W1
Im, DS; Koh, JM; Son, SE1
Bonifaz, LC; Cancino-Diaz, JC; Cancino-Diaz, ME; Castro-Escamilla, O; Martínez-Torres, I; Perez-Tapia, SM; Rodríguez-Martínez, S; Tepale-Segura, A1
Du, Z; Gu, H; Huang, J; Li, C; Liu, G; Shi, Y; Xu, Y; Zhang, L; Zhou, W1
Alani, R; Ali, D; Ardianto, C; Ayoub, R; Goh, KW; Jarrar, Q; Jilani, J; Moshawih, S1
Goto, H; Habe, K; Iida, S; Kondo, M; Matsushima, Y; Naka, M; Nakai, Y; Nishii, M; Yamanaka, K1
Ahmad, SF; Al-Harbi, NO; Alanazi, AZ; Alasmari, F; Alharbi, M; Alhazzani, K; Almutairi, M; Alqahtani, F; Alqarni, SA; Ibrahim, KE; Nadeem, A1
Bieler, T; Daiber, A; Karbach, S; Keller, K; Knopp, T; Kropp, A; Lagrange, J; Molitor, M; Münzel, T; Rauh, M; Ringen, J; Sies, K; Titze, J; Waisman, A; Wenzel, P; Wild, J1
Fu, FH; Li, XX; Lin, YW; Liu, B; Ma, L; Qi, R; Xing, X1
Correa Atella, G; Donato-Trancoso, A; Romana-Souza, B1
Adachi, A; Egawa, G; Gunzer, M; Honda, T; Hossain, MR; Ikuta, K; Kabashima, K; Kanameishi, S; Komine, M; Miyake, T; Ohtsuki, M; Takimoto, R1
Bansal, AK; Parmar, PK; Rohit, A; Sharma, N; Wasil Kabeer, S1
Chen, LC; Cheng, YP; Guo, JW; Liu, CY1
Cho, H; Hwang, ES; Je, JH; Jeon, Y; Jeong, MG; Kang, J; Lee, K; Song, J1
Chen, XY; Landeck, L; Man, XY; Wang, P; Wang, ZY; Xu, F; Yan, BX; Zheng, M; Zhou, Y1
Chen, Z; Hu, L; Lei, X; Li, S; Liu, J; Liu, Y; Song, Z; Wei, Z; Xiang, R; Yang, Y1
Guo, M; Lai, R; Lei, Q; Xian, D; Xian, L; Xu, J; Yang, Y; Zhao, Y; Zhong, J1
Dashti, M; Haghnnavaz, N; Moghadam, M; Pordel, S; Rezaee, M; Sankian, M; Shobeiri, SS1
Chen, X; Kuang, Y; Li, J; Liu, N; Liu, P; Peng, C; Yan, B; Yi, X; Zhu, W1
Chen, P; Li, X; Shao, Z; Xu, X1
Chen, Y; Li, X; Song, S; Wang, Y; Zhu, J1
Cai, Y; Chen, L; Ding, C; Hu, X; Li, X; Liu, N; Qin, H; Rouchka, EC; Tieri, D; Wang, L; Xu, Q; Xue, F; Yan, J; Zheng, J1
Arakawa, Y; Arita, T; Asai, J; Katoh, N; Masuda, K; Nakamura, K1
Abe, T; Hida, T; Ichimiya, S; Ikegami, I; Inoue, KI; Kamada, Y; Kamekura, R; Kamiya, S; Kamiya, T; Kobayashi, K; Sato, T; Takaki, H; Uhara, H; Yanagi, M1
Cui, K; Gu, L; Hao, Y; Hu, J; Hu, Y; Hu, Z; Huang, N; Li, J; Li, W; Liu, X; Luo, F; Wang, X; Wang, Z; Wei, X; Wu, W; Yu, J; Yue, C; Zeng, F; Zhang, C; Zhao, F; Zhao, Q; Zheng, H; Zhou, H; Zhou, P; Zhou, Y1
Chen, X; Chen, Y; Hu, W; Hua, L; Liang, S; Ou, Y; Sun, P; Wu, X; Yang, X; Yang, Z; Yue, H; Zhou, Y1
Bai, Y; Cao, L; Chen, S; Chen, W; Fan, W; Ge, H; Li, B; Li, Z; Liu, M; Luo, S; Mao, Y; Shen, J; Sun, L; Wang, D; Wang, Y; Yong, L; Yu, Y; Zhang, C; Zhang, R; Zhen, Q1
Chen, Z; Gao, WQ; Hao, W; Lin, J; Tang, J; Wang, L; Xu, H; Yang, M; You, Q; Zhao, X1
Wu, X; Xiang, S; Xiang, Y1
Di, T; Feng, F; Hu, X; Li, P; Meng, Y; Qi, C; Wang, Y; Zhang, X; Zhao, J; Zhao, N1
Daien, CI; King, NJC; Macia, L; Mielle, J; Moore, RJ; Ni, D; Pinget, GV; Simpson, S; Stanley, D; Taitz, J; Tan, JK1
Chen, J; He, L; Liu, L; Niu, Y; Qi, H; Qin, S; Yu, S1
Cai, H; Chen, X; Chen, Y; Hu, W; Hua, L; Liang, S; Lin, G; Liu, Z; Ou, Y; Sun, P; Wu, X; Yang, Z; Zhou, Y1
AAl-Haidari, R; Ah Mostafa, M; Alhaddad, A; N Al Busaidi, H; Samman, W; Samuel Kelechi, M; Sarkar, D; Sm, F1
Bhardwaj, P; Gupta, R; Pandey, S; Ramchandra Patil, P; Tripathi, P1
He, L; Li, C; Li, M; Qiao, P; Shao, S; Wang, G; Wang, Z; Zhang, J; Zhang, K; Zhang, Y1
Huang, C; Huang, F; Li, B; Lin, D; Wang, S; Xu, C; Zhang, T1
Carlos, ECDS; Cristovão, GA; Ribeiro, BCS; Romana-Souza, B; Silva, AA1
Li, M; Liu, C; Liu, S; Lu, J; Tang, J; Zhou, X; Zhu, L1
Jiang, C; Li, H; Qi, Q; Zhou, Y; Zou, W1
Dai, C; Guo, X; Jiang, F; Wang, J; Wu, X; Yin, Q1
Chen, Y; Chikazawa, S; Ichimasu, N; Katagiri, K; Kobayashi, K; Suzuki, S1
Hou, JJ; Jia, HY; Qiu, HY; Wu, Y; Zhang, MD; Zhou, ML1
Gu, J; Shi, Y; Wang, H; Yao, L; Yu, Q; Zhang, X; Zhao, Z1
Huang, J; Jin, H; Wang, Y1
Bai, D; Cheng, X; Hao, J; Li, Q; Lu, F; Sun, T; Zhang, B; Zhang, Y1
Chen, J; Chen, R; Jin, N; Li, Y; Zhang, B; Zhang, Z1
Li, W; Yang, C; Yang, W1
Duan, J; Duan, R; Gao, S; Li, J; Li, X; Ma, X; Qin, Y; Shi, R; Zhang, L; Zhao, R1
Huo, R; Li, H; Shen, B; Sheng, H; Shu, J; Sun, H; Sun, Y; Zhai, T; Zhang, J1
Li, H; Wang, J; Wang, S; Xiong, Y; Zhou, X1
Chen, H; Ge, W; Huang, Y; Jiang, J; Jin, Z; Kong, Y; Li, F; Li, L; Li, M; Liu, X; Zeng, X; Zhanmu, O1
Chen, JQ; Chen, XY; Cui, YZ; Fu, NC; Landeck, L; Man, XY; Wang, ZY; Xu, F; Yan, BX; Yang, XY; Zhou, Y1
Abram, CL; Bevilacqua, D; Cassatella, MA; Caveggion, E; Cestari, T; Constantin, G; Costa, S; De Sanctis, F; Donini, M; Dusi, S; Gasperini, S; Girolomoni, G; Lonardi, S; Lowell, CA; Pettinella, F; Rodegher, P; Scapini, P; Tagliaro, F; Ugel, S; Vermi, W; Zenaro, E1
Cui, H; Guo, H; Li, S; Li, X; Li, Y; Li, Z; Nandakumar, KS1
Asaji, M; Chang, J; Hattori, H; Higo, T; Hikoso, S; Ichi, I; Inui, H; Ito, K; Kamada, Y; Kanno, K; Koseki, M; Nishida, M; Nishihara, S; Ohama, T; Okada, T; Okuzaki, D; Omatsu, T; Ono, M; Saga, A; Saibara, T; Sakata, Y; Tanaka, K; Yamashita, S; Zhu, Y1
Chen, C; Chen, M; Chen, X; Hou, G; Kuang, Y; Li, J; Li, L; Lin, L; Liu, P; Peng, C; Su, J; Yan, B; Zhu, W1
Chenyang, W; Fushida, N; Hamaguchi, Y; Horii, M; Ikawa, Y; Kitano, T; Komuro, A; Matsushita, T; Nakabori, I; Sawada, K; Xibei, J1
Dong, BQ; Jiang, S; Lei, TC; Liao, ZK; Luo, LF; Miao, F; Yao, YZ1
Bhavana, V; Chary, PS; Mehra, NK; Pardhi, E; Singh, SB; Sulthana, S1
Bai, M; Deng, H; Fan, X; Guo, M; Li, Z; Liu, W; Meng, Q; Shi, Y; Sun, R; Yang, X; Yuan, D1
Li, K; Nandakumar, KS; Ou, J; Wang, T; Wu, H1
Kim, J; Kim, KI; Lee, A; Lim, JS; Park, KC1
Chen, H; Huang, Y; Jiang, J; Jin, Z; Kong, Y; Li, L; Liu, X; Tong, Q; Wei, F; Yin, J; Zhang, Y1
Banfi, G; Casciano, F; Gornati, L; Granucci, F; Guerrini, R; Marzola, E; Mingozzi, F; Montico, G; Protti, G; Reali, E; Secchiero, P; Volinia, S1
Cai, Z; Shi, X; Wang, W; Zeng, Y; Zhang, X; Zhu, H1
Lian, LH; Nan, JX; Wu, YL; Yang, HX; Zhan, ZY; Zhang, ZH1
Christensen, PKF; Hansen, AK; Høyer-Hansen, MH; Koch, J; Larsen, J; Martel, BC; Skov, S1
Jiang, D; Li, J; Lyu, Y; Wu, D; Xin, X; Yang, L; Yin, L; Zhou, Y; Zhu, Y1
Cheng, G; Jin, S; Liu, W; Mi, R; Pan, W; Piao, H; Zou, M1
Clausen, BE; Hsiao, YP; Kelel, M; Lee, CH; Lee, YL; Liang, PH; Liu, FT; Lu, CH; Su, SH; Tan, YF; Tsai, CH; Tsai, TF; Weng, HJ; Yeh, CY1
Hartmann, JN; Häsler, R; Philippsen, R; Piticchio, SG; Rose-John, S; Schwarz, A; Schwarz, T1
Chen, H; Chen, K; Hu, Y; Huang, D; Ju, M; Liu, L; Luan, C; Zhang, J; Zhou, X1
Ando, M; Fukuyama, T; Iwashita, N; Kushiro, M; Takagi, Y; Yamaguchi, H1
Che, D; Hang, B; Li, K; Li, Y; Wang, H; Wang, K1
Li, H; Li, X; Lin, N; Liu, L; Lu, Y; Luo, D; Sun, X; Wang, J; Yin, C; Zhang, M; Zhou, Y1
Egusa, C; Harada, K; Hayakawa, K; Maeda, T; Okubo, Y1
Chen, X; Lei, Y; Liu, Y; Lyu, C; Yang, Y; Ye, Y; Zhang, T; Zhou, X1
Chodaczek, G; Kupczyk, P; Makarec, A; Makuch, S; Woźniak, M; Ziółkowski, P1
Chang, YC; Chen, CH; Chen, PJ; Chen, SH; Fang, SY; Hwang, TL; Tsai, SC; Tsai, YF; Tseng, HH; Wang, YH1
Cheng, D; Dong, G; Li, C; Liu, C; Shi, D; Wang, C; Wei, L; Xiong, H; Yan, F; Yang, Z; Zhang, H; Zhang, J; Zhang, Y1
Benoist, C; Hanna, BS; Hsu, YC; Mathis, D; Ortiz-Lopez, A; Sassone-Corsi, M; Shwartz, Y; Zarin, P1
Choi, JH; Jung, SY; Kim, DW; Lee, KA; Park, S; Park, SH1
Hillman, PF; Jung, YR; Kang, JH; Kang, TB; Kim, JH; Lee, SB; Nam, SJ; Sim, EJ1
Chen, X; He, Y; Huang, X; Jia, H; Liu, T; Shan, W; Sun, R; Yang, Q1
Abdallah, OY; Atia, NM; El-Aal, SAA; Ibrahim, SSA; Reda, AM; Shahine, Y; Sheta, E1
Chen, C; Chen, M; Chen, X; Kuang, Y; Li, J; Li, L; Liu, P; Peng, C; Su, J; Yan, B; Zhou, Y; Zhu, W1
Cao, YC; Cui, WY; Kong, SM; Sun, XY1
Chen, X; Chu, C; Han, J; Huang, X; Li, X; Lin, Z; Wang, F; Xiong, Y; Xu, R1
Bang, J; Bareja, R; Desman, G; Ding, W; Elemento, O; Eljalby, M; Granstein, RD; Miller, LS; Reilly, MD; Vyas, NS; You, J; Yusupova, M; Zippin, JH1
Hu, Y; Huang, K; Huang, Q; Huang, W; Li, Q; Weng, D; Xu, W; Yao, S; Zheng, X; Zhou, C1
Li, G; Li, L; Li, S; Li, X; Wu, F1
Cai, X; Du, J; Gao, W; Gong, H; Lu, H; Xiao, H; Xu, J; Yang, Y1
Liu, Q; Ren, C; Wang, D; Wang, Q; Zhang, H1
Jiang, Y; Lai, Y; Lu, S; Wang, L1
Al Rudaisat, M; Amanullah, M; Chen, S; Chen, X; Cheng, H; Hua, C; Liang, Q; Song, Y; van der Veen, S; Wang, X; Zhou, C1
Amalia, SN; Baral, H; Fujiwara, C; Hosoi, M; Inoue, Y; Ishikawa, M; Kosaka, K; Motegi, SI; Ogino, S; Sekiguchi, A; Shibasaki, K; Torii, R; Uchiyama, A; Yamazaki, S; Yokoyama, Y1
Dai, SM; Deng, H; Guo, M; Liu, N; Liu, W; Meng, Q; Su, Y; Wei, M; Zhuang, H1
Lin, J; Lin, P; Lu, YY; Shi, HY1
Chen, S; Ding, K; Huang, H; Huang, T; Lv, W; Ma, S; Rong, Z; Wang, X; Yang, B; Zhang, X; Zheng, B; Zhong, Y1
Feng, S; Guo, D; Guo, T; Li, A; Li, S; Li, Y; Wang, B; Wang, Q; Yin, S1
Han, X; Li, P; Lin, Y; Liu, X; Xie, X; Zhang, L1
Fu, D; Fu, X; Hu, H; Li, J; Li, M; Song, X; Tian, Z; Wang, Q; Yan, D; Yang, Z; Zheng, S1
Li, L; Liu, J; Tian, C; Xia, A; Xia, Z; Yang, S; You, J; Zhang, G1
Luo, F; Luo, M; Pan, Y; Peng, Y; Ran, C; Wang, B; Wang, H; Wang, L; Yan, YN; Yi, T; Zhang, Y; Zhou, R1
Antal, D; Bai, P; Demény, MÁ; Dull, K; Kiss, B; Kovács, I; Póliska, S; Pór, Á; Szántó, M; Szegedi, A; Szöllősi, AG; Ujlaki, G1
An, B; Hong, N; Kong, Q; Liu, F; Sang, H; Shan, Y; Wu, Y; Yu, P; Zhang, X1
Abourehab, MAS; Hazari, SA; Kesharwani, P; Sheikh, A; Tulbah, AS1
Bai, Y; Chen, W; Ge, H; Li, B; Li, Z; Liu, H; Mao, Y; Sun, L; Wang, D; Wang, Y; Yu, Y; Zhen, Q1
Chu, MY; Lee, CL; Liu, CT; Song, YC; Wang, CM; Yen, HR1
Pu, S; Sun, L; Zhao, K; Zhou, D1
Li, P; Lin, Y; Liu, X; Wang, N; Xie, X; Zhang, L1
Cao, Z; Du, L; Han, C; Li, M; Liu, Z; Wei, J; Xu, Q; Zhang, C; Zhu, X1
Li, Y; Liu, Q; Ma, X; Wang, A; Wei, F; Zhang, H1
Bhattacharyya, S; Gorai, P; Modak, BK; Mondal, A; Mondal, NK; Pramanik, A; Sarkar, D1
Becker, M; Bezdek, S; Bieber, K; Gross, N; Gullberg, D; Gupta, Y; Hdnah, A; Ibrahim, SM; Künzel, S; Ludwig, RJ; Mousavi, S; Prüssmann, J; Sadik, CD; Sayegh, JP; Sezin, T; Vorobyev, A1
Chan, CI; Chen, SJ; Hseu, JH; Hseu, YC; Vadivalagan, C; Wu, PY; Yang, HL; Yen, HR1
Aji, A; Chen, T; Chu, YX; Li, FL; Wang, H; Wang, YQ; Xu, S; Zhang, C; Zhu, SJ1
Abreu, EP; Bittencourt, FV; Gontijo, JRV; Schwan, NV1
Jiang, L; Sun, S; Wang, Q; Zhang, Y1
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Fukaya, S; Fukuyasu, A; Hayashi, K; Ishikawa, T; Kamata, M; Ohnishi, T; Shimizu, T; Tada, Y; Tanaka, T1
Honda, K; Lee, HC; Ohba, M; Okuno, T; Takahashi, N; Takamori, K; Tominaga, M; Yasukawa, K; Yokomizo, T1
Iversen, L; Johansen, C; Ommen, P; Weimar, I1
Chen, X; Fang, F; Yi, F; Zhang, J; Zheng, X; Zhou, B1
Hooper, KM; Jensen, LE; Lian, LH; Milora, KA; Uribe-Herranz, M1
Asano, Y; Hau, CS; Kamata, M; Kanda, N; Noda, S; Sato, S; Shibata, S; Tada, Y; Tatsuta, A; Watanabe, S1
Asano, Y; Ishiura, N; Kadono, T; Kamata, M; Sato, S; Shibata, S; Sugaya, M; Tada, Y; Tedder, TF; Yanaba, K1
Bäumer, W; Dickhaut, J; Japtok, L; Kietzmann, M; Kleuser, B; Mischke, R; Schaper, K1
Hu, J; Li, H; Wen, C; Yang, R; Zhao, H; Zhao, M; Zhou, Q1
Becher, B; Cheong, C; Clausen, BE; Haak, S; Holzmann, B; Kant, M; Ober-Blöbaum, JL; Onderwater, S; Pantelyushin, S; Prens, EP; Reizis, B; Weighardt, H; Wohn, C; Zahner, SP1
Hu, J; Sun, J; Zhao, Y1
Hu, JH; Li, H1
Hu, J; Li, H; Wen, C; Yang, R; Zhao, H1
Barnes, BJ1
Flutter, B; Nestle, FO1
Dou, W; Hu, J; Sun, J; Zhao, Y1
Hau, CS; Kanda, N; Sato, S; Shibata, S; Tada, Y; Watanabe, S1
Honda, T; Kabashima, K; Malissen, B; Nakamizo, S; Nakamura, M; Ohmori, S; Sawada, Y; Sugita, K; Tokura, Y; Yoshiki, R; Yoshioka, H1
Choi, EJ; Hong, MP; Kie, JH; Kim, HR; Lee, A; Lee, HK; Lim, W; Moon, BI; Seoh, JY1
Abe, J; Ishii, S; Kita, Y; Matsushima, K; Nakamura, M; Sato, S; Shimizu, T; Sumida, H; Yanagida, K1
Bai, XC; Chen, TY; Feng, JY; Li, YM; Ma, J; Qin, S; Wen, J; Zheng, RC; Zhong, BL; Zhou, GB1
Alvarez, D; Naval, E; Ordovas-Montanes, J; Paust, S; Perro, M; Riol-Blanco, L; Thiriot, A; von Andrian, UH; Wood, JN1
Diem, S; Dy, M; Eberl, G; Latour, S; Leite-de-Moraes, MC; Massot, B; Michel, ML; Ohnmacht, C1
Byamba, D; Jee, H; Kim, DS; Kim, DY; Kim, SH; Kim, TG; Lee, MG; Lee, SK; Park, TY; Yang, SH1
Ahlfors, H; Di Meglio, P; Duarte, JH; Gilchrist, MJ; Hirota, K; Li, Y; Mrowietz, U; Nestle, FO; Owens, ND; Stockinger, B; Tosi, I; Villanova, F1
Sadik, CD; Sezin, T; Zillikens, D1
Iversen, L; Johansen, C; Kragballe, K; Steiniche, T; Vinter, H1
Ha, HL; Kim, JC; Morasso, MI; Pisitkun, P; Siebenlist, U; Tang, W; Tassi, I; Udey, MC; Wang, H1
Clausen, BE; Ober-Blöbaum, JL; Pantelyushin, S; Wohn, CT1
Amberg, N; Brunner, PM; Drobits, B; Glitzner, E; Holcmann, M; Kopp, T; Korosec, A; Schonthaler, HB; Sibilia, M; Stingl, G; Wagner, EF1
Boakye, CH; Godugu, C; Mendonca Faria, HA; Patel, AR; Singh, M; Somagoni, J; Zucolotto, V1
Asahina, A; Hau, C; Kamata, M; Mitsui, A; Sato, S; Shibata, S; Tada, Y1
Huo, R; Li, H; Li, N; Shen, B; Sun, Y; Wu, P; Zhai, T; Zhang, J; Zhou, Z; Zhu, X1
Borkner, L; Frenzel, DF; Scharffetter-Kochanek, K; Scheurmann, J; Singh, K; Weiss, JM1
Hjuler, KF; Iversen, L; Johansen, C; Khatib, SH; Kjellerup, RB; Langkilde, A; Raaby, L; Vinter, H1
Hsieh, WL; Huang, YH; Ming, YC; Pang, JH; Tsai, CN; Wang, TM1
Guo, Q; Han, Y; Tan, G; Tang, Z; Xiong, H; Xu, W; Xu, Y; Zeng, F1
Gao, Q; Ge, J; Song, S; Su, Z; Sun, G; Sun, W; Sun, X; Wang, H; Wang, Y; Xie, S; Yi, L; Zhang, B1
Fukami, K; Kanemaru, K; Matsuyuki, A; Nakamura, Y1
Kim, CH; Kim, JY; Lee, AY1
Flagler, ND; Janardhan, KS; King, D; Myers, P; Petranka, JG; Putney, JW; Steinckwich, N1
Anderegg, U; Busch, M; Herbert, D; Janik, T; Saalbach, A; Simon, JC1
Dejager, L; Grine, L; Libert, C; Vandenbroucke, RE1
Jessen, N; Kjær, TN; Pedersen, SB; Stenderup, K; Thorsen, K1
Aluwi, MF; Mohd Amin, MC; Rehman, K; Rullah, K; Wai, LK; Zulfakar, MH1
Arora, N; Pandey-Rai, S; Shah, K1
Chen, F; Chen, Y; Cheng, L; Hao, F; Niu, J; Qian, T; Shi, X; Song, Z; Wang, H; Yan, H; Zhai, Z; Zhang, D; Zhang, N; Zhong, B1
Fan, H; Harris, J; Jones, SA; Morand, EF; Perera, DN; Russ, BE1
Chen, X; Huo, R; Li, H; Li, N; Shen, B; Shen, Z; Sun, Y; Wang, B; Wu, P; Zhai, T; Zhang, J; Zhou, Z1
Bando, Y; Honma, M; Igawa, S; Iinuma, S; Iizuka, H; Ishida-Yamamoto, A; Kishibe, M; Saito, N; Takahashi, H; Yoshida, S1
Aihara, M; Komitsu, N; Watanabe, T; Watanabe, Y; Yamaguchi, Y1
Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Al-Hosaini, KA; Al-Sharary, SD; Ansari, MA; Attia, SM; El-Sherbeeny, AM; Nadeem, A; Siddiqui, N; Zoheir, KM1
Asano, Y; Hau, CS; Kadono, T; Kadowaki, T; Kamata, M; Kubota, N; Kurokawa, M; Masamoto, Y; Mitsui, A; Sato, S; Shibata, S; Sugaya, M; Tada, Y; Yamauchi, T1
Di, T; Li, P; Lin, Y; Liu, X; Wang, Y; Zeng, Z; Zhang, L; Zhao, J1
Ando, N; Aoki, R; Ishimaru, K; Nakamura, Y; Nakao, A; Ogawa, H; Okumura, K; Shibata, S; Shimada, S1
Chen, CC; Fang, JY; Kao, HC; Lin, YK; Yang, SH1
Abbatiello, B; Ajami, NJ; Belkaid, Y; Chen, Q; Chen, W; Chen, ZJ; Chia, C; Jiao, X; Kasagi, S; Konkel, JE; Nakatsukasa, H; Petrosino, JF; Smith, DP; Wu, R; Zanvit, P; Zhang, D1
Bertelsen, T; Hailfinger, S; Iversen, L; Johansen, C; Lorscheid, S; Mose, M; Ommen, P; Schulze-Osthoff, K; Vinter, H1
Kang, KS; Kim, TY; Park, KH; Sah, SK; Yun, CO1
Bajenoff, M; Chelbi, R; Dalod, M; Henri, S; Jorquera, A; Malissen, B; Malosse, C; Tamoutounour, S; Terhorst, D; Wohn, C1
Ishii, T; Kageyama, T; Kawashima, K; Kose, K; Kubo, N; Misawa, H; Moriwaki, Y; Nagasaki, T; Takada, K; Tsuji, S1
Li, MH; Lin, CC; Pan, IH; Wen, SF; Wu, HC; Yao, HJ1
Barrat, FJ; Elkon, KB; Fitzgerald, KA1
Babu, RJ; Boakye, CH; Desai, PR; Kikwai, LC; Patlolla, R; Shah, PP; Singh, M1
Gaestel, M; Iversen, L; Johansen, C; Kragballe, K; Steiniche, T; Vinter, H1
Charpin-El Hamri, G; Fussenegger, M; Geering, B; Schukur, L1
Hu, J; Sun, J; Wang, X1
Amiaud, J; Bart, G; Blanchard, F; Bourreille, A; Boutet, MA; Brulin, B; Charrier, C; Gabay, C; Le Goff, B; Lecron, JC; Morel, F; Palmer, G; Penhoat, M; Rolli-Derkinderen, M; Vigne, S1
Fukusato, T; Hau, CS; Kanda, N; Sato, S; Shibata, S; Tada, Y; Uozaki, H; Watanabe, S1
Liu, JH; Luo, DQ; Wu, HH; Xie, WL; Zhao, YK1
Di, T; Li, P; Liang, D; Liu, X; Wang, Y; Zhao, J1
Fukui, T; Matsuzaki, Y; Nakano, H; Rokunohe, A; Rokunohe, D; Sakuraba, Y; Sawamura, D1
Ait-Oufella, H; Bagot, M; Battistella, M; Bensussan, A; Bouaziz, JD; Boufenzer, A; Cochaud, S; Gibot, S; Hau, E; Joffre, J; Laurans, L; Le Buanec, H; Masson, A; Zeboudj, L1
Di, TT; Li, P; Liu, X; Ruan, ZT; Wang, Y; Zhao, JX1
Ballegeer, M; Grine, L; Libert, C; Lienenklaus, S; Sanders, NN; Steeland, S; Van Ryckeghem, S; Vandenbroucke, RE; Weiss, S1
Ban, CY; Choi, YJ; Kim, HP; Kim, J; Kim, JH; Kim, SC; Kim, SE; Kim, TG; Lee, BH; Park, J; Park, SH; Shin, EC; Song, MY; Sung, YC1
Adhami, VM; Chamcheu, JC; Chaves-Rodriquez, MI; Longley, BJ; Mukhtar, H; Siddiqui, IA; Wood, GS1
Bao, YL; Huang, YX; Li, WL; Li, YX; Song, ZB; Sun, LG; Wang, Q; Yang, XG; Yu, CL; Zhang, WJ1
Grine, L; Libert, C; Vandenbroucke, RE1
Birault, V; Brusq, JM; Bui, T; Cote-Sierra, J; Hofland, H; Jetten, AM; Millerman, E; Neil, J; Nicodeme, E; Peredo, CE; Rickard, D; Smith, SH; Takeda, Y; Therrien, JP; Viviani, F1
Chao, YH; Chen, DY; Chen, HH; Chung, TW; Li, YR; Lin, CC; Yang, DH1
Cao, W; Chen, G; Gao, Q; Song, S; Su, Z; Wang, H; Xie, S; Xu, H; Yin, S; Zhang, B1
Chang, KT; Choo, YK; Kim, CH; Kim, JS; Kim, SU; Lee, JM; Yoo, JK1
Cho, D; Houh, Y; Kim, KE; Park, HJ1
Morimura, S; Oka, T; Sato, S; Sugaya, M1
Cao, T; Fang, H; Hu, J; Jin, L; Li, B; Shao, S; Wang, G; Zhang, J; Zhang, Y1
Hahn, M; Hövelmeyer, N; Karbach, SH; Klebow, S; Nikoalev, A; Waisman, A; Wunderlich, FT1
Cochez, PM; Coulie, PG; Dauguet, N; de Heusch, M; Dumoutier, L; Hendrickx, E; Lemaire, MM; Michiels, C; Renauld, JC; Ryffel, B; Togbe, D; Van Belle, AB; Warnier, G1
Iversen, L; Johansen, C; Vinter, H1
Amiaud, J; Atanassov, H; Bernard, FX; Blanchard, F; Favot, L; Guesdon, W; Jégou, JF; Lecron, JC; Mcheik, J; Mekouo, AA; Morel, F; Paris, I; Pohin, M; Rabeony, H; Richards, CD1
Dainichi, T; Hirakawa, S; Honda, T; Kabashima, K; Kitoh, A; Miyachi, Y; Nakajima, S; Nakashima, C; Nonomura, Y; Otsuka, A; Wong, LS; Yamamoto, Y1
Bugara, B; Celada, A; Ferran, M; Florencia, EF; Giménez-Arnau, A; Jura, J; Lipert, B; Prens, EP; Pujol, RM; Ruiz-Romeu, E; Santamaria-Babí, LF1
Liu, JH; Luo, DQ; Wang, F; Wu, HH; Zhao, YK1
Bai, S; Hou, S; Liu, X; Zhang, Z1
Alrefai, H; Avots, A; Bukur, V; Goebeler, M; Kerstan, A; Klein-Hessling, S; Muhammad, K; Patra, AK; Pham, DA; Rudolf, R; Sahin, U; Serfling, E; Tenzer, S1
Shao, F; Sun, Y; Tan, T; Tan, Y; Wu, X; Xu, Q1
Bezdek, S; Hdnah, A; Ibrahim, S; Ludwig, RJ; Mousavi, S; Sadik, CD; Sezin, T; Zillikens, D1
Athari, SK; Bessis, N; Biton, J; Boissier, MC; Caux, F; Girard, JP; Herbelin, A; Hervé, R; Lemeiter, D; Poirier, E; Raffaillac, A; Semerano, L1
Cao, N; Chen, T; Fu, LX; Lu, YH; Yin, B; Zhang, LW; Zhou, PM1
Rahmani, F; Rezaei, N1
Benito, C; Casas, E; Ciruela, F; de Anta, JM; Díez-Villanueva, A; Ferran, M; Gómez, D; López-Cano, M; Manils, J; Marruecos, L; Perrino, FW; Soler, C; Vavouri, T; Viña-Vilaseca, A1
Chong, HT; Cowin, AJ; Ibbetson, J; Kopecki, Z; Sidhu, S; Yang, GN1
Amberg, N; Holcmann, M; Sibilia, M; Stulnig, G1
Adhami, VM; Chamcheu, JC; Chaves-Rodriquez, MI; Dodwad, SM; Esnault, S; Longley, BJ; Mukhtar, H; Satyshur, KA; Sechi, M; Siddiqui, IA; Syed, DN; Wood, GS1
Di, T; Li, P; Liang, D; Liu, X; Wang, Y; Zhang, G; Zhao, J1
Hercogová, J; Hornová, M; Hudcovic, T; Jůzlová, K; Klimešová, K; Kostovčík, M; Kverka, M; Málková, J; Novosádová, I; Rossmann, P; Stehlíková, Z; Štepánková, R; Tlaskalová-Hogenová, H; Zákostelská, Z1
Chen, YJ; Cheng, HY; Ho, LW; Huang, SW; Kao, JK; Narita, M; Shieh, JJ; Takahashi, M; Wang, ST; Wu, CY1
Li, R; Ma, H; Wang, J; Wang, M; Wang, X; Xiao, S; Zhou, J1
Iversen, L; Johansen, C; Langkilde, A; Ommen, P; Rosada, C; Stenderup, K; Stjernholm, T1
Albanesi, C; Avigliano, L; Cavani, A; Madonna, S; Mauriello, A; Melino, G; Palombo, R; Savini, I; Terrinoni, A1
Liu, J; Luo, H; OuYang, Q; Pan, Y; Xuan, C1
Li, D; Lohcharoenkal, W; Meisgen, F; Nikamo, P; Pivarcsi, A; Sonkoly, E; Srivastava, A; Ståhle, M; Xu Landén, N1
Burden, AD; Graham, GJ; Holmes, S; Le Brocq, ML; McKimmie, CS; Schalkwijk, J; Shams, K; Singh, M; van den Bogaard, EH; Wilson, GJ1
Bi, X; Deng, J; Dong, Z; Han, L; Mi, QS; Qu, L; Wu, D; Yin, C; Zhou, L1
Fang, F; Liu, X; Mei, L; Wang, H; Zhang, S1
Chen, Y; Hao, Y; Hu, J; Sun, J; Wang, L; Wang, X1
Choo, YK; Kim, CH; Kwak, DH; Lee, JH; Lee, JM; Lim, CY; Park, MY; Yoo, JK1
Bando, Y; Honma, M; Igawa, S; Iinuma, S; Ishida-Yamamoto, A; Kishibe, M; Saito, N; Yoshida, S1
Courthion, H; Denis, MC; Gabriel, D; Gurny, R; Kalia, Y; Karagianni, N; Kranidioti, K; Lapteva, M; Möller, M; Mugnier, T1
Finkelstein, D; Gangwar, R; Gingras, S; Häcker, H; Ippagunta, SK; Pelletier, S; Redecke, V; Vogel, P1
Brauner, S; Eidsmo, L; Gallais Serezal, I; Guerreiro-Cacais, AO; Jagodic, M; Lindahl, H; Martini, E; Nikamo, P; Olsson, T; Ståhle, M1
Domb, AJ; Doppalapudi, S; Jain, A; Khan, W1
Cao, T; Gao, T; Ge, R; Guo, S; Li, B; Li, C; Liu, L; Wang, G; Wang, H; Zhang, W1
Alessandrini, F; Becher, B; Freiberger, SN; Gyülveszi, G; Haak, S; Hofbauer, GF; Kishihara, K; Kulig, P; Kündig, T; Musiol, S; Pantelyushin, S; Russo, G; Sallusto, F; Schreiner, B1
Cho, KA; Kim, JY; Lee, KH; Park, M; Woo, SY1
Ballegeer, M; Bruscoli, S; Carceller, E; Deckers, J; Hochepied, T; Libert, C; Pérez, P; Riccardi, C1
Chen, W; Fei, C; Gong, Y; Shi, Y; Tong, Y; Wang, X; Wang, Y; Xu, H; Yu, Q; Zhang, X1
Cao, N; Chen, T; Fu, LX; Guo, ZP; Qin, S; Yin, B1
Espinosa, A; Iversen, L; Johansen, C; Langkilde, A; Ottosson, V; Raaby, L; Vinter, H; Wahren-Herlenius, M1
Gudjonsson, JE; Hawkes, JE; Ward, NL1
Fu, M; Gao, J; Li, W; Liu, Y; Sun, S; Wang, G; Xiao, C; Yao, X; Zhu, Z1
Borek, I; Clausen, BE; Farber, JM; Hedrick, MN; Kelsall, BL; Singh, SP; Singh, TP; Wolf, P; Zhang, HH1
Itankar, PR; Joshi, A; Parmar, KM; Prasad, SK1
Alvarez, P; Jensen, LE1
Florencia, EF; Hekking-Weijma, IM; Onderdijk, AJ; Prens, EP1
Cen, J; Chen, S; Han, K; Li, H; Wei, Q; Wu, H; Yang, Y1
Altavilla, D; Anastasi, GP; Arcoraci, V; Bitto, A; Cutroneo, G; Ettari, R; Irrera, N; Lentini, M; Minutoli, L; Pallio, G; Pizzino, G; Scuruchi, M; Squadrito, F; Vaccaro, M1
Cho, KA; Kim, JY; Kim, YH; Lee, KH; Park, M; Ryu, KH; Woo, SY1
Cochez, PM; Dauguet, N; Dumoutier, L; Hendrickx, E; Michiels, C; Renauld, JC; Warnier, G1
Cooper, KD; Groft, S; Honda, K; McCormick, TS; Oyetakin-White, P; Soler, DC; Tacastacas, JD; Young, A1
Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Almukhlafi, TS; El-Sherbeeny, AM; Nadeem, A1
Arita, K; Hirai, M; Kurebayashi, Y; Mori, H; Yamaguchi, T1
Ahmad, SF; Al-Harbi, MM; Al-Harbi, NO; Alotaibi, MR; AlSaad, AM; Ansari, MA; Nadeem, A1
Diaconu, D; Fritz, Y; Gudjonsson, JE; Liang, Y; Michaels, KA; Sarkar, MK; Sutter, AJ; Swindell, WR; Tsoi, A; Ward, NL; Xing, X1
Boon, L; Cornelissen, F; Florencia, E; Kant, M; Laman, JD; Lubberts, E; Mourits, S; Mus, AM; Prens, EP; van der Fits, L; Voerman, JS1
Ben Salem, C; Bouraoui, K; Hmouda, H1
Cordoro, KM; Greer, KE; Lonergan, CL; McNamara, EK1
Levine, VJ; Machler, BC; Mark, NM; Patel, U1
Carbajal, S; DiGiovanni, J; Elder, JT; Gudjonsson, JE; Han, G; Johnston, A; Lu, J; Nair, RP; Pittelkow, MR; Prens, EP; Sano, S; Swindell, WR; Voorhees, JJ; Wang, XJ; Ward, NL; Wohn, C; Xing, X1
Aguayo, R; Baradad, M; Casanova, JM; Sanmartín, V1
Akimoto, T; Ishizaki, M; Maeda, H; Matsuda, T; Muromoto, R; Ohshiro, Y; Oritani, K; Sekine, Y; Shimoda, K; Yokoyama, M1
Cheung, PH; Foreman, O; Hain, HS; Kaur, P; Kavirayani, A; Saha, S; Tung, D1
Desai, PR; Patel, AR; Shah, PP; Singh, MS1
de Heusch, M; Dumoutier, L; Dunussi-Joannopoulos, K; Fouser, LA; Hendrickx, E; Lemaire, MM; Renauld, JC; Van Belle, AB; Warnier, G1
Becher, B; Haak, S; Heppner, FL; Ingold, B; Kulig, P; Navarini, AA; Pantelyushin, S1
Baek, JO; Byamba, D; Kim, TG; Lee, MG; Wu, WH1
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Langtry, JA; Rajan, N1
Dika, E; Fanti, PA; Miscial, C; Vaccari, S; Varotti, C1

Reviews

10 review(s) available for imiquimod and Psoriasis

ArticleYear
Methodological shortcomings in the reports of the imiquimod psoriatic model.
    Experimental dermatology, 2022, Volume: 31, Issue:3

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Mice; Psoriasis; Skin

2022
Mouse Models of Psoriasis: A Comprehensive Review.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:3 Pt B

    Topics: Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Mice; Psoriasis; Skin

2022
Great green tea ingredient? A narrative literature review on epigallocatechin gallate and its biophysical properties for topical use in dermatology.
    Phytotherapy research : PTR, 2020, Volume: 34, Issue:9

    Topics: Administration, Topical; Antioxidants; Biophysical Phenomena; Catechin; Cosmetics; Dermatology; Humans; Imiquimod; Plant Extracts; Psoriasis; Tea

2020
Mesenchymal stem cells for the treatment of psoriasis: a comprehensive review.
    Clinical and experimental dermatology, 2020, Volume: 45, Issue:7

    Topics: Adjuvants, Immunologic; Adult; Animals; Cell Proliferation; Clinical Trials as Topic; Cytokines; Female; Fetal Blood; Humans; Imiquimod; Immunomodulation; Infusions, Intravenous; Keratinocytes; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Middle Aged; Models, Animal; Psoriasis; T-Lymphocytes; Treatment Outcome

2020
Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation.
    Journal of immunology research, 2017, Volume: 2017

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Cytokines; Dermatitis; Endosomes; Humans; Imiquimod; Indazoles; Isonicotinic Acids; Mice; Psoriasis; Resveratrol; Signal Transduction; Skin; Stilbenes; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptor 9; Toll-Like Receptors

2017
[Mechanism of psoriasis generation in animal models].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:6

    Topics: Aminoquinolines; Amphiregulin; Animals; Disease Models, Animal; EGF Family of Proteins; Humans; Imiquimod; Keratin-14; Keratin-5; Keratinocytes; Membrane Glycoproteins; Mice, Transgenic; Psoriasis; Receptor, TIE-2; STAT3 Transcription Factor; Toll-Like Receptor 7; Transforming Growth Factor beta1

2013
Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.
    Annual review of medicine, 2016, Volume: 67

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Autoimmunity; Cytosol; DNA, Viral; Endosomes; Humans; Imiquimod; Immunity, Innate; Inflammation; Lupus Erythematosus, Systemic; Nucleic Acids; Psoriasis; Signal Transduction; Toll-Like Receptors; Virus Diseases

2016
Therapeutic targeting of Toll-like receptors: a review of Toll-like receptors and their signaling pathways in psoriasis.
    Expert review of clinical immunology, 2016, Volume: 12, Issue:12

    Topics: Aminoquinolines; Animals; Cytokines; Dendritic Cells; Humans; Imiquimod; Keratinocytes; Molecular Targeted Therapy; Psoriasis; Signal Transduction; Toll-Like Receptors

2016
Imiquimod 5% cream induced psoriasis: a case report, summary of the literature and mechanism.
    The British journal of dermatology, 2011, Volume: 164, Issue:3

    Topics: Adjuvants, Immunologic; Aged; Aminoquinolines; Anti-Inflammatory Agents; Biopsy; Clobetasol; Humans; Imiquimod; Keratosis, Actinic; Male; Psoriasis; Treatment Outcome; Ultraviolet Therapy

2011
Mechanism of action and emerging role of immune response modifier therapy in dermatologic conditions.
    Journal of cutaneous medicine and surgery, 2004, Volume: 8 Suppl 3

    Topics: Adjuvants, Immunologic; Alefacept; Aminoquinolines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Calcineurin Inhibitors; CD11 Antigens; Dermatitis, Atopic; Glucocorticoids; Humans; Imiquimod; Interferons; Membrane Glycoproteins; Mycophenolic Acid; Psoriasis; Receptors, Cell Surface; Recombinant Fusion Proteins; Skin Diseases; Tacrolimus; Toll-Like Receptors

2004

Trials

1 trial(s) available for imiquimod and Psoriasis

ArticleYear
Does imiquimod pretreatment optimize 308-nm excimer laser (UVB) therapy in psoriasis patients?
    Photodermatology, photoimmunology & photomedicine, 2017, Volume: 33, Issue:4

    Topics: Administration, Topical; Adult; Aged; Aminoquinolines; Female; Humans; Imiquimod; Laser Therapy; Male; Middle Aged; Psoriasis

2017

Other Studies

698 other study(ies) available for imiquimod and Psoriasis

ArticleYear
The STING antagonist H-151 ameliorates psoriasis via suppression of STING/NF-κB-mediated inflammation.
    British journal of pharmacology, 2021, Volume: 178, Issue:24

    Topics: Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Skin

2021
Resveratrol-Loaded Vesicular Elastic Nanocarriers Gel in Imiquimod-Induced Psoriasis Treatment: In Vitro and In Vivo Evaluation.
    Journal of pharmaceutical sciences, 2022, Volume: 111, Issue:2

    Topics: Animals; Drug Liberation; Imiquimod; Mice; Psoriasis; Resveratrol; Skin Absorption

2022
Deciphering the mechanism of Fang-Ji-Di-Huang-Decoction in ameliorating psoriasis-like skin inflammation via the inhibition of IL-23/Th17 cell axis.
    Journal of ethnopharmacology, 2021, Dec-05, Volume: 281

    Topics: Animals; Copper; Drugs, Chinese Herbal; Gene Expression Regulation; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Mice; Phytotherapy; Psoriasis; Th17 Cells

2021
Differential role of TNFR1 and TNFR2 in the development of imiquimod-induced mouse psoriasis.
    Journal of leukocyte biology, 2021, Volume: 110, Issue:6

    Topics: Animals; Disease Models, Animal; Female; Imiquimod; Interferon Inducers; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; T-Lymphocytes, Regulatory

2021
Positive Allosteric Modulation of A
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:3 Pt A

    Topics: Adenosine; Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Immunity; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2022
Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF-κB and VEGFR2 signaling.
    International immunopharmacology, 2021, Volume: 100

    Topics: Animals; Apoptosis; Cell Proliferation; Cytokines; HaCaT Cells; Humans; Imiquimod; Indoles; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Neovascularization, Physiologic; NF-kappa B; Psoriasis; Signal Transduction; Skin; Vascular Endothelial Growth Factor Receptor-2

2021
Apremilast downregulates interleukin-17 production and induces splenic regulatory B cells and regulatory T cells in imiquimod-induced psoriasiform dermatitis.
    Journal of dermatological science, 2021, Volume: 104, Issue:1

    Topics: Animals; B-Lymphocytes, Regulatory; Disease Models, Animal; Down-Regulation; Female; Humans; Imiquimod; Interleukin-17; Mice; Psoriasis; Spleen; T-Lymphocytes, Regulatory; Thalidomide

2021
Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
    Journal of cellular physiology, 2022, Volume: 237, Issue:1

    Topics: Animals; Cell Proliferation; Humans; Hydrolases; Imiquimod; Inflammation; Keratinocytes; Mice; MicroRNAs; Psoriasis; Skin

2022
Cutaneous Liver X Receptor Activation Prevents the Formation of Imiquimod-Induced Psoriatic Dermatitis.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:4

    Topics: Administration, Cutaneous; Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Liver X Receptors; Psoriasis; Skin

2022
Topical Application of Vitamin D
    AAPS PharmSciTech, 2021, Sep-24, Volume: 22, Issue:7

    Topics: Animals; Cholecalciferol; Imiquimod; Mice; Nanoparticles; Particle Size; Psoriasis

2021
Integrated Metabolomics and Transcriptomics Analyses Reveal Histidine Metabolism Plays an Important Role in Imiquimod-Induced Psoriasis-like Skin Inflammation.
    DNA and cell biology, 2021, Volume: 40, Issue:10

    Topics: Animals; Female; Histidine; Imiquimod; Metabolome; Mice; Mice, Inbred C57BL; Psoriasis; Transcriptome

2021
Losartan ointment attenuates imiquimod-induced psoriasis-like inflammation.
    International immunopharmacology, 2021, Volume: 100

    Topics: Administration, Cutaneous; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Imiquimod; Interleukin-17; Losartan; Male; Mice; Ointments; Psoriasis; Receptor, Angiotensin, Type 1; Skin; Th17 Cells

2021
IL-30 ameliorates imiquimod and K14-VEGF induced psoriasis-like disease by inhibiting both innate and adaptive immunity disorders.
    Biochemical and biophysical research communications, 2021, 11-19, Volume: 579

    Topics: Adaptive Immunity; Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Cytokines; Humans; Imiquimod; Inflammation; Interleukins; Keratin-14; Keratinocytes; Lymphocytes; Mice; Psoriasis; Signal Transduction; Vascular Endothelial Growth Factor A

2021
First-in-class topical therapeutic omilancor ameliorates disease severity and inflammation through activation of LANCL2 pathway in psoriasis.
    Scientific reports, 2021, 10-06, Volume: 11, Issue:1

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Disease Susceptibility; Imiquimod; Immunosuppressive Agents; Inflammation Mediators; Keratinocytes; Membrane Proteins; Mice; Mice, Knockout; Phosphate-Binding Proteins; Psoriasis; Signal Transduction; T-Lymphocyte Subsets

2021
Alkyl-Terminated Gold Nanoparticles as a Self-Therapeutic Treatment for Psoriasis.
    Nano letters, 2021, 10-27, Volume: 21, Issue:20

    Topics: Animals; Disease Models, Animal; Gold; Imiquimod; Keratinocytes; Metal Nanoparticles; Mice; Nanoparticles; Psoriasis

2021
Psoriasiform Inflammation Is Associated with Mitochondrial Fission/GDAP1L1 Signaling in Macrophages.
    International journal of molecular sciences, 2021, Sep-27, Volume: 22, Issue:19

    Topics: Animals; Female; Humans; Imiquimod; Inflammation; Macrophages; Mice; Mice, Inbred BALB C; Mitochondrial Dynamics; Mitochondrial Proteins; Psoriasis; THP-1 Cells

2021
Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway.
    International journal of molecular sciences, 2021, Oct-05, Volume: 22, Issue:19

    Topics: Animals; Apoptosis; Biomarkers; Cell Cycle; Cell Proliferation; Cells, Cultured; Gene Expression Regulation; Humans; Imiquimod; Interferon Inducers; Keratinocytes; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Receptors, Lysophosphatidic Acid; rho-Associated Kinases

2021
Cudraxanthone D Ameliorates Psoriasis-like Skin Inflammation in an Imiquimod-Induced Mouse Model via Inhibiting the Inflammatory Signaling Pathways.
    Molecules (Basel, Switzerland), 2021, Oct-08, Volume: 26, Issue:19

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Female; Humans; Imiquimod; Interferon-gamma; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Moraceae; NF-kappa B; Plant Extracts; Plant Roots; Psoriasis; Treatment Outcome; Tumor Necrosis Factor-alpha; Xanthones

2021
Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways.
    Molecular medicine reports, 2021, Volume: 24, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Imiquimod; Inflammation; Interferon-gamma; Keratinocytes; Lignans; Mice, Inbred C57BL; NF-kappa B; Psoriasis; Signal Transduction; STAT1 Transcription Factor; Th1 Cells; Th17 Cells; Tumor Necrosis Factor-alpha

2021
MiR-193b-3p-ERBB4 axis regulates psoriasis pathogenesis via modulating cellular proliferation and inflammatory-mediator production of keratinocytes.
    Cell death & disease, 2021, 10-19, Volume: 12, Issue:11

    Topics: Animals; Antagomirs; Base Sequence; Cell Proliferation; Disease Models, Animal; Down-Regulation; Female; HaCaT Cells; Humans; Imiquimod; Inflammation; Inflammation Mediators; Keratinocytes; Male; Mice, Inbred C57BL; MicroRNAs; Models, Biological; Psoriasis; Receptor, ErbB-4; RNA, Messenger; Skin

2021
PI3Kδ Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis.
    Cells, 2021, 10-02, Volume: 10, Issue:10

    Topics: Administration, Topical; Animals; Apoptosis; Biomarkers; Cell Differentiation; Cell Movement; Cell Proliferation; Cytokines; Epithelium; Female; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Keratinocytes; Mice, Inbred BALB C; Models, Biological; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Psoriasis; Pyridines; Quinolines; Signal Transduction; Skin; Up-Regulation

2021
Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:5

    Topics: Adipocytes; Adipokines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Keratinocytes; Lysosomal Membrane Proteins; Mice; Psoriasis; STAT3 Transcription Factor

2022
Curcumin and ustekinumab cotherapy alleviates induced psoriasis in rats through their antioxidant, anti-inflammatory, and antiproliferative effects.
    Cutaneous and ocular toxicology, 2022, Volume: 41, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Curcumin; Cytokines; Disease Models, Animal; Imiquimod; Interleukin-12 Subunit p40; Interleukin-17; Psoriasis; Rats; Skin; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Ustekinumab

2022
NF-κB1 Contributes to Imiquimod-Induced Psoriasis-Like Skin Inflammation by Inducing Vγ4
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:6

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2022
Lymphatic Dysfunction Exacerbates Cutaneous Tumorigenesis and Psoriasis-Like Skin Inflammation through Accumulation of Inflammatory Cytokines.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:6

    Topics: Animals; Carcinogenesis; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Lymphatic System; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2022
TMT-based proteomics analysis reveals the protective effect of Jueyin granules on imiquimod-induced psoriasis mouse model by causing autophagy.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 96

    Topics: Animals; Autophagy; Disease Models, Animal; Humans; Imiquimod; Mice; Neoplasm Recurrence, Local; Proteomics; Psoriasis

2022
Use of Cytokine Mix-, Imiquimod-, and Serum-Induced Monoculture and Lipopolysaccharide- and Interferon Gamma-Treated Co-Culture to Establish In Vitro Psoriasis-like Inflammation Models.
    Cells, 2021, 11-02, Volume: 10, Issue:11

    Topics: Adult; Cells, Cultured; Coculture Techniques; Cytokines; Gene Expression Profiling; Gene Expression Regulation; Genetic Markers; HaCaT Cells; Humans; Imiquimod; Inflammation; Interferon-gamma; Keratinocytes; Lipopolysaccharides; Models, Biological; Psoriasis; RNA, Messenger; Serum; Tetradecanoylphorbol Acetate

2021
Total withanolides ameliorates imiquimod-induced psoriasis-like skin inflammation.
    Journal of ethnopharmacology, 2022, Mar-01, Volume: 285

    Topics: Animals; Computational Biology; Gene Expression Regulation; Imiquimod; Inflammation; Interferon Inducers; Male; Mice; Mice, Inbred BALB C; Protein Interaction Maps; Psoriasis; Random Allocation; Signal Transduction; Up-Regulation; Withanolides; Zonula Occludens-1 Protein

2022
Salubrinal protects against inflammatory response in macrophage and attenuates psoriasiform skin inflammation by antagonizing NF-κB signaling pathway.
    Biochemical and biophysical research communications, 2022, 01-22, Volume: 589

    Topics: Animals; Cinnamates; Disease Models, Animal; Imiquimod; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Protective Agents; Psoriasis; RAW 264.7 Cells; Signal Transduction; Skin; Thiourea; Tumor Necrosis Factor-alpha

2022
A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 145

    Topics: Administration, Topical; Animals; Anthraquinones; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Emodin; HaCaT Cells; Humans; Imiquimod; Inflammation; Keratinocytes; Macrophages; Mice; Psoriasis; Rheum; Skin Absorption; Swine

2022
Terrestrosin D ameliorates skin lesions in an imiquimod-induced psoriasis-like murine model by inhibiting the interaction between Substance P and Dendritic cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 95

    Topics: Animals; Cell Proliferation; Cytokines; Dendritic Cells; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Saponins; Skin; Substance P

2022
Decreased microRNA-126 expression in psoriatic CD4
    The Journal of dermatology, 2022, Volume: 49, Issue:4

    Topics: Animals; Cell Differentiation; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; MicroRNAs; Psoriasis; Skin; Th17 Cells

2022
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis.
    EMBO molecular medicine, 2022, 03-07, Volume: 14, Issue:3

    Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Mice; Psoriasis; Skin; Toll-Like Receptor 7

2022
Protective effect of Yangxue Jiedu Soup against psoriasis-like lesions by regulating TLR4/NF-κB signaling pathway mediated by secretion of exosome HSP70.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 147

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drugs, Chinese Herbal; HSP70 Heat-Shock Proteins; Imiquimod; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Phytotherapy; Psoriasis; Signal Transduction; Toll-Like Receptor 4

2022
Topical astilbin ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice via suppression dendritic cell-Th17 inflammation axis.
    Journal of cellular and molecular medicine, 2022, Volume: 26, Issue:4

    Topics: Animals; Cytokines; Dendritic Cells; Disease Models, Animal; Flavonols; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2022
[Effect of moxibustion on skin lesions and immune inflammatory response in psoriasis mice].
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2022, Jan-12, Volume: 42, Issue:1

    Topics: Animals; Imiquimod; Male; Mice; Moxibustion; Psoriasis; Skin; Spleen; Tumor Necrosis Factor-alpha

2022
Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling‒Mediated Sensory Neuron‒Dendritic Cell Communication.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:8

    Topics: Animals; Calcitonin Gene-Related Peptide; Cell Communication; Dendritic Cells; Imiquimod; Interleukin-23; Lidocaine; Pilot Projects; Psoriasis; Rats; Sensory Receptor Cells

2022
Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 147

    Topics: Animals; Disease Models, Animal; Female; Gels; Imiquimod; Interleukin-23; Langerhans Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pentacyclic Triterpenes; Psoriasis; Tripterygium

2022
SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model.
    EBioMedicine, 2022, Volume: 76

    Topics: Animals; Dendritic Cells; Humans; Imiquimod; Mice; Nucleic Acids; Psoriasis; Toll-Like Receptor 7; Toll-Like Receptor 9

2022
Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice.
    Mediators of inflammation, 2022, Volume: 2022

    Topics: Animals; Disease Models, Animal; Eczema; Imiquimod; Inflammation; Mice; Psoriasis; Skin

2022
TNFR2 Depletion Reduces Psoriatic Inflammation in Mice by Downregulating Specific Dendritic Cell Populations in Lymph Nodes and Inhibiting IL-23/IL-17 Pathways.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:8

    Topics: Animals; Dendritic Cells; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Lymph Nodes; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha

2022
LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2‒NLRC4 Axis.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:8

    Topics: Animals; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Keratinocytes; Lipocalin-2; Mice; Psoriasis; Skin; Sterol Regulatory Element Binding Protein 2

2022
Design and synthesis of the 4H-chromenone derivatives against psoriasis.
    Bioorganic chemistry, 2022, Volume: 120

    Topics: Animals; Disease Models, Animal; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Tumor Necrosis Factor-alpha

2022
Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model.
    European journal of medicinal chemistry, 2022, Mar-05, Volume: 231

    Topics: Animals; Disease Models, Animal; Imiquimod; Mice; Psoriasis; Receptors, Aryl Hydrocarbon; Skin; Th17 Cells

2022
Transcutaneous delivery of mung bean-derived nanoparticles for amelioration of psoriasis-like skin inflammation.
    Nanoscale, 2022, Feb-24, Volume: 14, Issue:8

    Topics: Animals; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; Skin; Vigna

2022
Activation of the STING-IRF3 pathway involved in psoriasis with diabetes mellitus.
    Journal of cellular and molecular medicine, 2022, Volume: 26, Issue:8

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Imiquimod; Interferon Regulatory Factor-3; Mice; Psoriasis

2022
Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice.
    Molecules (Basel, Switzerland), 2022, Feb-19, Volume: 27, Issue:4

    Topics: Animals; Anxiety; Behavior, Animal; Berberine; Imiquimod; Male; Mice; Mice, Inbred BALB C; Psoriasis

2022
KdPT alleviates imiquimod-induced psoriasis-like skin lesion in mice via inhibiting proliferation and inflammation response.
    Die Pharmazie, 2022, 02-01, Volume: 77, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Cytokines; Disease Models, Animal; Endothelial Cells; Imiquimod; Inflammation; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Tumor Necrosis Factor-alpha

2022
Selenium-Rich Yeast Peptide Fraction Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Inhibiting Inflammation via MAPK and NF-κB Signaling Pathways.
    International journal of molecular sciences, 2022, Feb-14, Volume: 23, Issue:4

    Topics: Animals; Cell Line; Dermatitis; Disease Models, Animal; Female; Humans; Hydrogen Peroxide; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Peptides; Psoriasis; RAW 264.7 Cells; Selenium; Signal Transduction; Skin; Yeasts

2022
Ginsenoside Rg1 ameliorates psoriasis-like skin lesions by suppressing proliferation and NLRP3 inflammasomes in keratinocytes.
    Journal of food biochemistry, 2022, Volume: 46, Issue:5

    Topics: Animals; Cell Proliferation; Ginsenosides; Humans; Imiquimod; Inflammasomes; Keratinocytes; Ki-67 Antigen; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Quality of Life; Reactive Oxygen Species; Sincalide

2022
The effectiveness of synthetic methoxylated isoflavones in delivering to the skin and alleviating psoriasiform lesions via topical absorption.
    International journal of pharmaceutics, 2022, Apr-05, Volume: 617

    Topics: Animals; Disease Models, Animal; Imiquimod; Isoflavones; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Swine

2022
Secretory leukocyte protease inhibitor regulates nerve reflex-mediated skin barrier function in psoriasis.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2022, Volume: 36, Issue:8

    Topics: Animals; Imiquimod; Mice; Psoriasis; Reflex; Secretory Leukocyte Peptidase Inhibitor; Skin

2022
D-Mannose Suppresses γδ T Cells and Alleviates Murine Psoriasis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Imiquimod; Inflammation; Intraepithelial Lymphocytes; Mannose; Mice; Psoriasis; Skin

2022
IL-17A Promotes Psoriasis-Associated Keratinocyte Proliferation through ACT1-Dependent Activation of YAP-AREG Axis.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:9

    Topics: Amphiregulin; Animals; Antibodies, Monoclonal, Humanized; Cell Proliferation; HaCaT Cells; Humans; Imiquimod; Interleukin-17; Keratinocytes; Mice; Psoriasis; Skin

2022
Adiponectin-derived pentapeptide ameliorates psoriasiform skin inflammation by suppressing IL-17 production in γδT cells.
    Journal of dermatological science, 2022, Volume: 106, Issue:1

    Topics: Adiponectin; Animals; Disease Models, Animal; Eczema; Imiquimod; Inflammation; Interleukin-17; Mice; Psoriasis; Receptors, Adiponectin; Skin

2022
Human umbilical cord-derived mesenchymal stem cells ameliorate psoriasis-like dermatitis by suppressing IL-17-producing γδ T cells.
    Cell and tissue research, 2022, Volume: 388, Issue:3

    Topics: Animals; Dermatitis; Humans; Imiquimod; Inflammation; Interleukin-17; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Psoriasis; T-Lymphocytes; Umbilical Cord

2022
Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis.
    The Journal of pharmacy and pharmacology, 2022, Sep-01, Volume: 74, Issue:9

    Topics: Animals; Ceramides; Cholesterol; Disease Models, Animal; Imiquimod; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Surface-Active Agents

2022
Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Benzylisoquinolines; Forkhead Transcription Factors; Imiquimod; Mice; Psoriasis; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; T-Lymphocytes, Regulatory

2022
Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis.
    Bioengineered, 2022, Volume: 13, Issue:4

    Topics: Animals; Imiquimod; Lipopolysaccharides; Macrophages; Methotrexate; Mice; Naphthoquinones; Psoriasis

2022
3, 3'- diindolylmethane hinders IL-17A/IL-17RA interaction and mitigates imiquimod-induced psoriasiform in mice.
    International immunopharmacology, 2022, Volume: 109

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Indoles; Interleukin-17; Janus Kinases; Keratinocytes; Mice; Psoriasis; Signal Transduction; Skin; STAT Transcription Factors; Vascular Endothelial Growth Factor A

2022
Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61.
    Journal of integrative medicine, 2022, Volume: 20, Issue:4

    Topics: Animals; China; Cysteine-Rich Protein 61; Disease Models, Animal; Drugs, Chinese Herbal; Imiquimod; Inflammation; Intercellular Adhesion Molecule-1; Interferon-gamma; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger

2022
CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:11

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Humans; Imiquimod; Inflammation; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Nerve Tissue Proteins; NF-kappa B; Psoriasis; Receptors, Nicotinic

2022
[Effect of fire needling on imiquimod induced psoriasis-like lesion and STAT3 pathway in mice].
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2022, May-12, Volume: 42, Issue:5

    Topics: Animals; Dexamethasone; Imiquimod; Interleukin-17; Ki-67 Antigen; Male; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger; Skin; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha

2022
Transglutaminase 3 Attenuates Skin Inflammation in Psoriasis by Inhibiting NF-κB Activation through Phosphorylated STAT3-TET3 Signaling.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:11

    Topics: Animals; Cysteamine; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; RNA, Small Interfering; Skin; STAT3 Transcription Factor; Transglutaminases

2022
Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.
    International journal of molecular sciences, 2022, Apr-19, Volume: 23, Issue:9

    Topics: Animals; Cytokines; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Acids, Omega-3; Imiquimod; Interleukin-17; Interleukin-23; Mice; Psoriasis; Skin

2022
The Protective Role of pVHL in Imiquimod-Induced Psoriasis-like Skin Inflammation.
    International journal of molecular sciences, 2022, May-07, Volume: 23, Issue:9

    Topics: Animals; Dermatitis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imiquimod; Inflammation; Interleukin-17; Mice; Psoriasis; Tumor Necrosis Factor-alpha; Von Hippel-Lindau Tumor Suppressor Protein

2022
The Essential Oil Derived from
    Molecules (Basel, Switzerland), 2022, May-07, Volume: 27, Issue:9

    Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-1; Interleukin-17; Interleukin-23; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Oils, Volatile; Perilla frutescens; Psoriasis; Skin

2022
Synthesis and In-Vivo Evaluation of Benzoxazole Derivatives as Promising Anti-Psoriatic Drugs for Clinical Use.
    Molecules (Basel, Switzerland), 2022, May-08, Volume: 27, Issue:9

    Topics: Animals; Benzoxazoles; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred CBA; Pharmaceutical Preparations; Psoriasis; Skin

2022
Psoriasis-like skin lesions occurring at remote sites after topical imiquimod.
    The Journal of dermatology, 2022, Volume: 49, Issue:10

    Topics: Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases

2022
Lck signaling inhibition causes improvement in clinical features of psoriatic inflammation through reduction in inflammatory cytokines in CD4+ T cells in imiquimod mouse model.
    Cellular immunology, 2022, Volume: 376

    Topics: Adjuvants, Immunologic; Animals; CD4-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Mice; Psoriasis; Pyrazoles; Pyrimidines; Skin; Tumor Necrosis Factor-alpha

2022
Epicutaneous Application of Imiquimod to Model Psoriasis-Like Skin Disease Induces Water-Saving Aestivation Motifs and Vascular Inflammation.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:11

    Topics: Animals; Disease Models, Animal; Estivation; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases; Water

2022
Notch1/Hes1‑PTEN/AKT/IL‑17A feedback loop regulates Th17 cell differentiation in mouse psoriasis‑like skin inflammation.
    Molecular medicine reports, 2022, Volume: 26, Issue:1

    Topics: Animals; Cell Differentiation; Dermatitis; Feedback; Imiquimod; Inflammation; Interleukin-17; Lymphadenopathy; Mechanistic Target of Rapamycin Complex 1; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Skin; Splenomegaly; Th17 Cells; Transcription Factor HES-1

2022
Dietary olive oil intake aggravates psoriatic skin inflammation in mice via Nrf2 activation and polyunsaturated fatty acid imbalance.
    International immunopharmacology, 2022, Volume: 108

    Topics: Animals; Dermatitis; Diet; Disease Models, Animal; Fatty Acids, Unsaturated; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Olive Oil; Psoriasis; Skin; Skin Diseases

2022
Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions.
    The Journal of allergy and clinical immunology, 2022, Volume: 150, Issue:4

    Topics: Animals; Disease Models, Animal; Estradiol; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Macrophages; Mice; Mice, Knockout; Neutrophils; Psoriasis; Receptors, Estrogen; Skin

2022
Nanocrystal-based gel of apremilast ameliorates imiquimod-induced psoriasis by suppressing inflammatory responses.
    International journal of pharmaceutics, 2022, Jun-25, Volume: 622

    Topics: Animals; Disease Models, Animal; Gels; Imiquimod; Nanoparticles; Psoriasis; Skin; Thalidomide

2022
Lithosepermic Acid Restored the Skin Barrier Functions in the Imiquimod-Induced Psoriasis-like Animal Model.
    International journal of molecular sciences, 2022, May-31, Volume: 23, Issue:11

    Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2022
Dimeric translationally controlled tumor protein-binding peptide 2 attenuates imiquimod-induced psoriatic inflammation through induction of regulatory T cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 152

    Topics: Animals; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Peptides; Psoriasis; Skin; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Protein, Translationally-Controlled 1

2022
Sprouty1 exerts a preventive effect on the initiation of psoriasis by inhibiting innate immune antimicrobial peptide cathelicidin and immunocytes.
    Cell proliferation, 2022, Volume: 55, Issue:10

    Topics: Animals; Antimicrobial Cationic Peptides; Antimicrobial Peptides; Cathelicidins; Disease Models, Animal; Eosine Yellowish-(YS); Hematoxylin; Humans; Imiquimod; Immunity, Innate; Inflammation; Interleukin-17; Keratinocytes; Membrane Proteins; Mice; Phosphoproteins; Psoriasis; Skin

2022
Tiamulin inhibits TNF-α and alleviates psoriasis-like dermatitis.
    Journal of dermatological science, 2022, Volume: 107, Issue:1

    Topics: Animals; Dermatitis; Disease Models, Animal; Diterpenes; Imiquimod; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Tumor Necrosis Factor-alpha

2022
An Emerging Role of
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Imiquimod; Interleukin-17; Interleukin-23; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Proanthocyanidins; Psoriasis; Reactive Oxygen Species; RNA, Messenger; Skin; Superoxide Dismutase; Vascular Endothelial Growth Factor A

2022
Anti-IL-17A ssDNA aptamer ameliorated psoriasis skin lesions in the imiquimod-induced psoriasis mouse model.
    International immunopharmacology, 2022, Volume: 110

    Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; DNA, Single-Stranded; Imiquimod; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Psoriasis; RNA, Messenger; Skin

2022
Topical VX-509 attenuates psoriatic inflammation through the STAT3/FABP5 pathway in keratinocytes.
    Pharmacological research, 2022, Volume: 182

    Topics: Animals; Disease Models, Animal; Fatty Acid-Binding Proteins; Heterocyclic Compounds, 2-Ring; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Psoriasis; Skin; STAT3 Transcription Factor; Valine

2022
DPP-4 inhibitor linagliptin ameliorates imiquimod-induced psoriasis-like skin alterations in type 2 diabetic mice by inhibiting the MAPK/NF-κB inflammatory pathway.
    Drug development research, 2022, Volume: 83, Issue:6

    Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Hypoglycemic Agents; Imiquimod; Insulin Resistance; Interleukin-23; Linagliptin; Mice; NF-kappa B; Psoriasis; Tumor Necrosis Factor-alpha

2022
Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17/IL-17 axis by activating PPARγ.
    Phytotherapy research : PTR, 2022, Volume: 36, Issue:10

    Topics: Animals; Disease Models, Animal; Estrogens; Flavonoids; Imiquimod; Interleukin-17; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; PPAR gamma; Protein Kinases; Psoriasis; Skin; Skin Diseases; Th17 Cells; Tumor Necrosis Factor-alpha; Wnt Signaling Pathway

2022
Dynamic trafficking patterns of IL-17-producing γδ T cells are linked to the recurrence of skin inflammation in psoriasis-like dermatitis.
    EBioMedicine, 2022, Volume: 82

    Topics: Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-17; Mice; Psoriasis; Skin; T-Lymphocytes

2022
Exacerbation of psoriatic arthritis due to topical imiquimod therapy.
    International journal of dermatology, 2023, Volume: 62, Issue:3

    Topics: Administration, Topical; Aminoquinolines; Animals; Arthritis, Psoriatic; Disease Models, Animal; Humans; Imiquimod; Psoriasis; Skin

2023
Functional Interplay between IL-9 and Peptide YY Contributes to Chronic Skin Inflammation.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:12

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-9; Keratinocytes; Mice; Peptide YY; Psoriasis; Skin

2022
SerpinB7 deficiency contributes to development of psoriasis via calcium-mediated keratinocyte differentiation dysfunction.
    Cell death & disease, 2022, 07-21, Volume: 13, Issue:7

    Topics: Animals; Calcium; Cell Proliferation; Epidermis; Humans; Imiquimod; Keratinocytes; Mice; Psoriasis; Serpins

2022
Ciclopirox inhibits NLRP3 inflammasome activation via protecting mitochondria and ameliorates imiquimod-induced psoriatic inflammation in mice.
    European journal of pharmacology, 2022, Sep-05, Volume: 930

    Topics: Animals; Ciclopirox; Imiquimod; Inflammasomes; Inflammation; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Reactive Oxygen Species

2022
Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice.
    Nature communications, 2022, 07-22, Volume: 13, Issue:1

    Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Disease Models, Animal; Humans; Imiquimod; Inflammation; Keratinocytes; Macrophages; Mice; Psoriasis

2022
Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice.
    Stem cell research & therapy, 2022, 08-03, Volume: 13, Issue:1

    Topics: Administration, Topical; Animals; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin 1 Receptor Antagonist Protein; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Secretome; Skin

2022
Sinomenine Suppressed Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis by Regulating lncRNA XIST.
    Skin pharmacology and physiology, 2022, Volume: 35, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; RNA, Long Noncoding; Skin Diseases

2022
Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 105

    Topics: Amino Acids; Animals; Carnitine; Cimicifuga; Cytokines; Disease Models, Animal; Imiquimod; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Network Pharmacology; Plant Extracts; Psoriasis; RNA-Seq; Skin; Smilax

2022
Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development.
    Cell reports, 2022, 08-16, Volume: 40, Issue:7

    Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Imiquimod; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Psoriasis

2022
Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models.
    Lipids in health and disease, 2022, Aug-18, Volume: 21, Issue:1

    Topics: Animals; Cholesterol Ester Transfer Proteins; Disease Models, Animal; Imiquimod; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phospholipid Transfer Proteins; Psoriasis

2022
Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice.
    Chemico-biological interactions, 2022, Sep-25, Volume: 365

    Topics: Animals; Carrier Proteins; Caspase 1; Chlorquinaldol; Cytokines; Dermatitis; Female; Imiquimod; Inflammasomes; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Nucleotides; Psoriasis; Pyrin Domain

2022
Effect on ethanolic extract of sechiumedule fruitson imquimod-induced psoriasis like dermatitis in wistar rats.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:4

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Male; Mice; Psoriasis; Rats; Rats, Wistar; Skin

2022
Cyclosporine and Pentoxifylline laden tailored niosomes for the effective management of psoriasis: In-vitro optimization, Ex-vivo and animal study.
    International journal of pharmaceutics, 2022, Oct-15, Volume: 626

    Topics: Animals; Cholesterol; Cyclosporine; Imiquimod; Liposomes; Mice; Particle Size; Pentoxifylline; Polysorbates; Psoriasis; Surface-Active Agents

2022
Decreasing GDF15 Promotes Inflammatory Signals and Neutrophil Infiltration in Psoriasis Models.
    The Journal of investigative dermatology, 2023, Volume: 143, Issue:3

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Psoriasis; Skin

2023
NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice.
    Journal of ethnopharmacology, 2023, Jan-10, Volume: 300

    Topics: Alanine; Animals; Asparagine; Aspartic Acid; Cytokines; Disease Models, Animal; Glucose; Histidine; Imiquimod; Interleukin-17; Interleukin-23; Interleukin-8; Magnetic Resonance Spectroscopy; Mice; Moxibustion; Psoriasis; Skin; Taurine; Triglycerides; Valine

2023
Imiquimod-induced ex vivo model of psoriatic human skin via interleukin-17A signalling of T cells and Langerhans cells.
    Experimental dermatology, 2022, Volume: 31, Issue:11

    Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Langerhans Cells; Psoriasis; Skin; T-Lymphocytes

2022
Inhibition of JAK1/STAT3 pathway by 2-methoxyestradiol ameliorates psoriatic features in vitro and in an imiquimod-induced psoriasis-like mouse model.
    European journal of pharmacology, 2022, Oct-15, Volume: 933

    Topics: 2-Methoxyestradiol; Animals; Cell Proliferation; Dermatitis; Disease Models, Animal; Endothelial Cells; Humans; Imiquimod; Interleukin-17; Janus Kinase 1; Keratinocytes; Mercaptoethanol; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ointments; Psoriasis; Skin; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A

2022
[The number of regulatory T cells in spleen and serum-related cytokines increase in mouse model of psoriasis induced by imiquimod].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2022, Volume: 38, Issue:10

    Topics: Animals; Cytokines; Disease Models, Animal; Female; Imiquimod; Interleukin-10; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Spleen; T-Lymphocytes, Regulatory; Transforming Growth Factor beta1

2022
Novel RNA polymerase I inhibitor CX-5461 suppresses imiquimod-induced experimental psoriasis.
    Experimental dermatology, 2023, Volume: 32, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antiviral Agents; Disease Models, Animal; Endothelial Cells; Imiquimod; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Psoriasis; RNA Polymerase I; Skin

2023
Oestrogen inhibits psoriasis-like dermatitis induced by imiquimod in mice in relation to increased IL-10 producing cells despite elevated expression of IL-22, IL-23, IL-17 mRNA.
    Experimental dermatology, 2023, Volume: 32, Issue:2

    Topics: Animals; Dermatitis; Disease Models, Animal; Estrogens; Female; Imiquimod; Inflammation; Interleukin-10; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger

2023
Lenalidomide attenuates IMQ-induced inflammation in a mouse model of psoriasis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 156

    Topics: Animals; Disease Models, Animal; Imiquimod; Inflammation; Lenalidomide; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Skin; Tumor Microenvironment

2022
Efficient local delivery of FK506 using blocking patches in psoriasis.
    Journal of colloid and interface science, 2023, Jan-15, Volume: 630, Issue:Pt A

    Topics: Administration, Cutaneous; Animals; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Tacrolimus

2023
Reduction of Methyltransferase-like 3-Mediated RNA N6-Methyladenosine Exacerbates the Development of Psoriasis Vulgaris in Imiquimod-Induced Psoriasis-like Mouse Model.
    International journal of molecular sciences, 2022, Oct-21, Volume: 23, Issue:20

    Topics: Adenosine; Animals; Disease Models, Animal; Humans; Imiquimod; Inflammation; Methyltransferases; Mice; Psoriasis; RNA; RNA, Messenger

2022
Eupatilin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like skin lesions in mice via the p38 MAPK/NF-κB signaling pathway.
    Immunopharmacology and immunotoxicology, 2023, Volume: 45, Issue:2

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Imiquimod; Interleukin-17; Interleukin-23; Interleukin-6; Keratinocytes; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Psoriasis; Skin; Skin Diseases; Tumor Necrosis Factor-alpha

2023
Transcutaneous amorphous preparation co-delivering curcumin and modified aptamer as a synergistic approach for the amelioration of psoriasis-like skin inflammation.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2023, Jan-01, Volume: 180

    Topics: Curcumin; Glycyrrhizic Acid; Humans; Imiquimod; Psoriasis; Silicon Dioxide

2023
Knockdown of Bcl-3 alleviates psoriasis and dyslipidemia comorbidity by regulating Akt pathway.
    Allergologia et immunopathologia, 2022, Volume: 50, Issue:6

    Topics: Animals; Apolipoproteins E; Cholesterol; Comorbidity; Disease Models, Animal; Dyslipidemias; Glycogen Synthase Kinase 3 beta; Imiquimod; Leukemia, B-Cell; Mice; Mice, Inbred BALB C; NF-kappa B; Proto-Oncogene Proteins c-akt; Psoriasis; RNA, Small Interfering; Skin

2022
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
    British journal of pharmacology, 2023, Volume: 180, Issue:5

    Topics: Animals; Dermatitis; Disease Models, Animal; Guinea Pigs; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Rabbits; Skin

2023
CCN1 upregulates IL-36 via AKT/NF-κB and ERK/CEBP β-mediated signaling pathways in psoriasis-like models.
    The Journal of dermatology, 2023, Volume: 50, Issue:3

    Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Proto-Oncogene Proteins c-akt; Psoriasis; Signal Transduction; Skin

2023
Tryptanthrin ameliorates imiquimod-induced psoriasis in mice by suppressing inflammation and oxidative stress via NF-κB/MAPK/Nrf2 pathways.
    Journal of natural medicines, 2023, Volume: 77, Issue:1

    Topics: Animals; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Psoriasis; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2023
Role of Type I Cannabinoid Receptor in Sensory Neurons in Psoriasiform Skin Inflammation and Pruritus.
    The Journal of investigative dermatology, 2023, Volume: 143, Issue:5

    Topics: Animals; Eczema; Imiquimod; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Pruritus; Psoriasis; Receptors, Cannabinoid; Sensory Receptor Cells; Substance P

2023
Mupirocin blocks imiquimod-induced psoriasis-like skin lesion by inhibiting epidermal isoleucyl-tRNA synthetase.
    Cell communication and signaling : CCS, 2022, 11-22, Volume: 20, Issue:1

    Topics: Animals; Humans; Imiquimod; Isoleucine-tRNA Ligase; Mice; Mice, Inbred C57BL; Mupirocin; Psoriasis; Skin Diseases

2022
Neutrophils inhibit γδ T cell functions in the imiquimod-induced mouse model of psoriasis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Disease Models, Animal; Disease Progression; Eczema; Imiquimod; Mice; NADP; NADPH Oxidases; Neutrophils; Psoriasis

2022
Kaempferol modulates IFN-γ induced JAK-STAT signaling pathway and ameliorates imiquimod-induced psoriasis-like skin lesions.
    International immunopharmacology, 2023, Volume: 114

    Topics: Animals; Disease Models, Animal; Imiquimod; Interferon-gamma; Janus Kinases; Kaempferols; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Signal Transduction; Skin; STAT Transcription Factors; Suppressor of Cytokine Signaling Proteins

2023
A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice.
    International journal of molecular sciences, 2022, Dec-13, Volume: 23, Issue:24

    Topics: Animals; Dermatitis; Diet, High-Fat; Disease Models, Animal; Imiquimod; Ketocholesterols; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxysterols; Psoriasis

2022
Lipidomic profiling reveals metabolic signatures in psoriatic skin lesions.
    Clinical immunology (Orlando, Fla.), 2023, Volume: 246

    Topics: Animals; Ceramides; Disease Models, Animal; Imiquimod; Inflammation; Keratinocytes; Lipidomics; Lipids; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
FcγRIIB inhibits inflammation in a murine model of psoriasis.
    Journal of dermatological science, 2022, Volume: 108, Issue:2

    Topics: Animals; Dermatitis; Disease Models, Animal; Forkhead Transcription Factors; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2022
Uncoupling melanogenesis from proliferation in epidermal melanocytes responding to stimulation with psoriasis-related proinflammatory cytokines.
    Journal of dermatological science, 2022, Volume: 108, Issue:2

    Topics: Animals; Cell Proliferation; Cytokines; Humans; Imiquimod; Interleukin-8; Melanins; Melanocytes; Mice; Microphthalmia-Associated Transcription Factor; Psoriasis; RNA, Small Interfering; Tumor Necrosis Factor-alpha

2022
Development and evaluation emulgel for effective management of the imiquimod-induced psoriasis.
    Inflammopharmacology, 2023, Volume: 31, Issue:1

    Topics: Animals; Body Weight; Disease Models, Animal; Imiquimod; Inflammation; Male; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
Inhibition of Serum- and Glucocorticoid-Regulated Protein Kinase-1 Aggravates Imiquimod-Induced Psoriatic Dermatitis and Enhances Proinflammatory Cytokine Expression through the NF-kB Pathway.
    The Journal of investigative dermatology, 2023, Volume: 143, Issue:6

    Topics: Animals; Cytokines; Dermatitis; Glucocorticoids; Imiquimod; Mice; NF-kappa B; Protein Kinases; Psoriasis; Toll-Like Receptor 7

2023
Comparative studies on mannan and imiquimod induced experimental plaque psoriasis inflammation in inbred mice.
    Clinical and experimental immunology, 2023, 03-24, Volume: 211, Issue:3

    Topics: Animals; Dexamethasone; Disease Models, Animal; Imiquimod; Inflammation; Mannans; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
Alleviation of imiquimod-induced psoriasis-like symptoms in Rorα-deficient mouse skin.
    BMB reports, 2023, Volume: 56, Issue:5

    Topics: Animals; Imiquimod; Inflammation; Keratinocytes; Mice; Psoriasis; Skin

2023
Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Group IV Phospholipases A2; Imiquimod; Lipid Metabolism; Mice; Phospholipids; Psoriasis

2022
CCR4
    European journal of immunology, 2023, Volume: 53, Issue:4

    Topics: Animals; Arthritis, Psoriatic; CD8-Positive T-Lymphocytes; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, Antigen, T-Cell; Receptors, CCR4; Skin Diseases

2023
Benvitimod inhibits MCM6-meditated proliferation of keratinocytes by regulating the JAK/STAT3 pathway.
    Journal of dermatological science, 2023, Volume: 109, Issue:2

    Topics: Animals; Cell Proliferation; Imiquimod; Keratinocytes; Mice; Psoriasis; Resorcinols

2023
Potential skin health promoting benefits of costunolide: a therapeutic strategy to improve skin inflammation in imiquimod-induced psoriasis.
    Food & function, 2023, Mar-06, Volume: 14, Issue:5

    Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Health Promotion; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Sesquiterpenes; Skin

2023
Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity.
    PloS one, 2023, Volume: 18, Issue:2

    Topics: Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Psoriasis; Skin

2023
Topical Delivery of ROS-Responsive Methotrexate Prodrug Nanoassemblies by a Dissolvable Microneedle Patch for Psoriasis Therapy.
    International journal of nanomedicine, 2023, Volume: 18

    Topics: Animals; Imiquimod; Methotrexate; Mice; NF-kappa B; Polyesters; Prodrugs; Psoriasis; Reactive Oxygen Species; Skin

2023
Tacrolimus and paclitaxel co-loaded O/O ointment without surfactant: Synergistic combinations for the treatment of psoriasis.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2023, Volume: 185

    Topics: Humans; Imiquimod; Ointments; Paclitaxel; Psoriasis; Pulmonary Surfactants; Surface-Active Agents; Tacrolimus

2023
PD-L1 Enhanced by cis-Urocanic Acid on Langerhans Cells Inhibits Vγ4
    The Journal of investigative dermatology, 2023, Volume: 143, Issue:8

    Topics: Animals; B7-H1 Antigen; Dermatitis; Humans; Imiquimod; Inflammation; Interleukin-23; Langerhans Cells; Mice; Psoriasis; Ultraviolet Rays; Urocanic Acid

2023
Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Adenylyl Cyclases; Animals; Humans; Imiquimod; Inflammation; Interleukin-17; Mice; Mice, Knockout; Microbiota; Psoriasis; T-Lymphocytes, Regulatory

2023
IL-33-mediated activation of mast cells is involved in the progression of imiquimod-induced psoriasis-like dermatitis.
    Cell communication and signaling : CCS, 2023, 03-09, Volume: 21, Issue:1

    Topics: Animals; Dermatitis; Imiquimod; Interleukin-33; Mast Cells; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
Oral exposure to citrinin significantly exacerbates the pathophysiology of a mouse model of imiquimod-induced psoriasis via direct activation of dendritic cell.
    Journal of applied toxicology : JAT, 2023, Volume: 43, Issue:9

    Topics: Aminoquinolines; Animals; Citrinin; Dendritic Cells; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression.
    International journal of dermatology, 2023, Volume: 62, Issue:7

    Topics: Animals; Apoptosis; Cell Adhesion Molecules; Cell Line; Cell Proliferation; Humans; Imiquimod; Keratinocytes; Mice; Psoriasis; Up-Regulation

2023
Aberrant promoter methylation of Wnt inhibitory factor-1 gene is a potential target for treating psoriasis.
    Clinical immunology (Orlando, Fla.), 2023, Volume: 250

    Topics: Animals; Decitabine; Disease Models, Animal; DNA Methylation; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Promoter Regions, Genetic; Psoriasis; Skin

2023
Topical application of imatinib mesylate ameliorated psoriasis-like skin lesions in imiquimod-induced murine model via angiogenesis inhibition.
    Experimental dermatology, 2023, Volume: 32, Issue:6

    Topics: Animals; Disease Models, Animal; Humans; Imatinib Mesylate; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases; Vascular Endothelial Growth Factor A

2023
Fufang Shengdi mixture alleviates psoriasis-like skin inflammation via promoting Annexin-A proteins expression.
    Journal of ethnopharmacology, 2023, Aug-10, Volume: 312

    Topics: Animals; Annexins; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases; Tumor Necrosis Factor-alpha

2023
The Impact of Proinflammatory Cytokines and Imiquimod on GLUT1 in HaCaT Keratinocytes - a Potential Anti-Psoriatic Therapeutic Target?
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2023, Mar-22, Volume: 57, Issue:2

    Topics: Animals; Cytokines; Disease Models, Animal; Glucose Transporter Type 1; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Tumor Necrosis Factor-alpha

2023
Palbociclib blocks neutrophilic phosphatidylinositol 3-kinase activity to alleviate psoriasiform dermatitis.
    British journal of pharmacology, 2023, Volume: 180, Issue:16

    Topics: Animals; Anti-Inflammatory Agents; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis

2023
Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Animals; Imiquimod; Interleukins; Mice; Mice, Knockout; Myeloid-Derived Suppressor Cells; Nitric Oxide Synthase Type II; Psoriasis

2023
Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin.
    Proceedings of the National Academy of Sciences of the United States of America, 2023, 04-04, Volume: 120, Issue:14

    Topics: Animals; Dermatitis; Imiquimod; Inflammation; Mice; Psoriasis; Receptors, Cell Surface; Skin; Skin Diseases; T-Lymphocytes, Regulatory

2023
Impact of Obesity on the IL-6 Immune Marker and Th17 Immune Cells in C57BL/6 Mice Models with Imiquimod-Induced Psoriasis.
    International journal of molecular sciences, 2023, Mar-15, Volume: 24, Issue:6

    Topics: Animals; Biomarkers; Cytokines; Disease Models, Animal; Imiquimod; Interleukin-6; Mice; Mice, Inbred C57BL; Obesity; Psoriasis; Skin; Th17 Cells

2023
    International journal of molecular sciences, 2023, Mar-15, Volume: 24, Issue:6

    Topics: Caspase 1; Caspases; Cornus; Dermatitis; DNA-Binding Proteins; HEK293 Cells; Humans; Imiquimod; Inflammasomes; Inflammation; Interleukin-1beta; NLR Family, Pyrin Domain-Containing 3 Protein; Plant Extracts; Psoriasis; Seeds

2023
Specific Activation of CB2R Ameliorates Psoriasis-Like Skin Lesions by Inhibiting Inflammation and Oxidative Stress.
    Inflammation, 2023, Volume: 46, Issue:4

    Topics: Animals; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Kelch-Like ECH-Associated Protein 1; Keratinocytes; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oxidative Stress; Psoriasis; Skin; Skin Diseases

2023
Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance.
    Inflammopharmacology, 2023, Volume: 31, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Diosmin; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; MicroRNAs; Nanoparticles; NF-kappa B; Proto-Oncogene Proteins c-akt; Psoriasis; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Skin; Toll-Like Receptor 7; TOR Serine-Threonine Kinases

2023
Lysophosphatidylcholine facilitates the pathogenesis of psoriasis through activating keratinocytes and T cells differentiation via glycolysis.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2023, Volume: 37, Issue:7

    Topics: Animals; Cell Differentiation; Disease Models, Animal; Imiquimod; Keratinocytes; Lysophosphatidylcholines; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Diseases

2023
Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
    Current medical science, 2023, Volume: 43, Issue:2

    Topics: Animals; Cell Proliferation; Cytokines; Imiquimod; Keratinocytes; Mice; Psoriasis

2023
Translation-dependent skin hyperplasia is promoted by type 1/17 inflammation in psoriasis.
    Journal of dermatological science, 2023, Volume: 110, Issue:1

    Topics: Animals; Disease Models, Animal; Eukaryotic Initiation Factor-4E; Humans; Hyperplasia; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Tumor Necrosis Factor-alpha

2023
Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.
    Experimental dermatology, 2023, Volume: 32, Issue:7

    Topics: Adenylyl Cyclases; Animals; Disease Models, Animal; Eczema; Imiquimod; Inflammation; Mice; Psoriasis; Skin; Th17 Cells

2023
Protein Kinase CK2 Promotes Proliferation, Abnormal Differentiation, and Proinflammatory Cytokine Production of Keratinocytes via Regulation of STAT3 and Akt Pathways in Psoriasis.
    The American journal of pathology, 2023, Volume: 193, Issue:5

    Topics: Animals; Casein Kinase II; Cell Differentiation; Cell Proliferation; Cytokines; Humans; Imiquimod; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-akt; Psoriasis; Skin; STAT3 Transcription Factor

2023
Etanercept ameliorates psoriasis progression through regulating high mobility group box 1 pathway.
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2023, Volume: 29, Issue:4

    Topics: Animals; Disease Models, Animal; Etanercept; HMGB1 Protein; Imiquimod; Inflammation; Keratinocytes; Lipopolysaccharides; Mice; Psoriasis; Receptor for Advanced Glycation End Products

2023
Piperine ameliorates psoriatic skin inflammation by inhibiting the phosphorylation of STAT3.
    International immunopharmacology, 2023, Volume: 119

    Topics: Alkaloids; Animals; Cytokines; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Phosphorylation; Psoriasis; Skin; STAT3 Transcription Factor

2023
    Allergologia et immunopathologia, 2023, Volume: 51, Issue:3

    Topics: Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukins; Keratinocytes; Mice; Psoriasis; Skin; TEA Domain Transcription Factors; Th1 Cells; Th17 Cells; Transcription Factor AP-2

2023
Topical histone deacetylase 1 inhibitor Entinostat ameliorates psoriasiform dermatitis through suppression of IL-17A response.
    Journal of dermatological science, 2023, Volume: 110, Issue:3

    Topics: Animals; Disease Models, Animal; Eczema; Histone Deacetylase 1; Humans; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
RNA sequencing and metabolic analysis of imiquimod-induced psoriasis-like mice with chronic restrain stress.
    Life sciences, 2023, Aug-01, Volume: 326

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Sequence Analysis, RNA; Skin

2023
TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System.
    The Journal of investigative dermatology, 2023, Volume: 143, Issue:12

    Topics: Adenosine Triphosphate; Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Knockout; Neuropeptides; Psoriasis; Skin; TRPV Cation Channels

2023
SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Animals; Dermatitis; Imiquimod; Inflammation; Interleukin-23; Macrophages; Mice; Psoriasis; Sirtuin 3; Toll-Like Receptor 7; X-Box Binding Protein 1

2023
Centella asiatica alleviates psoriasis through JAK/STAT3-mediated inflammation: An in vitro and in vivo study.
    Journal of ethnopharmacology, 2023, Dec-05, Volume: 317

    Topics: Animals; Antioxidants; Centella; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Skin

2023
SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis.
    Cell death & disease, 2023, 06-09, Volume: 14, Issue:6

    Topics: Animals; Cell Proliferation; Disease Models, Animal; Homeostasis; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Nucleotide Transport Proteins; Psoriasis

2023
Benzoylaconitine Alleviates Progression of Psoriasis via Suppressing STAT3 Phosphorylation in Keratinocytes.
    Molecules (Basel, Switzerland), 2023, May-31, Volume: 28, Issue:11

    Topics: Animals; Cell Proliferation; Cytokines; Disease Models, Animal; Imiquimod; Keratinocytes; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Phosphorylation; Psoriasis; Skin; Tumor Necrosis Factor-alpha

2023
Liangxue Jiedu formula improves imiquimod-induced psoriasiform dermatitis with circadian desynchrony by regulating Th17 cell differentiation based on network pharmacological analysis.
    Journal of ethnopharmacology, 2023, Dec-05, Volume: 317

    Topics: Animals; Cell Differentiation; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Th17 Cells

2023
Anti-interleukin 33 treatment alleviates psoriatic dermatitis in mice induced imiquimod.
    International immunopharmacology, 2023, Volume: 121

    Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-33; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
Discovery of 5-((1H-indazol-3-yl) methylene)-2-thioxoimidazolidin-4-one derivatives as a new class of AHR agonists with anti-psoriasis activity in a mouse model.
    Bioorganic & medicinal chemistry letters, 2023, 08-15, Volume: 92

    Topics: Animals; Imiquimod; Indazoles; Mice; Psoriasis; Receptors, Aryl Hydrocarbon; Skin

2023
NEK2 overexpression aggravates IL-22-induced keratinocyte proliferation and cytokine level increases and IMQ-induced psoriasis-like dermatitis.
    Biochimica et biophysica acta. Molecular cell research, 2023, Volume: 1870, Issue:8

    Topics: Animals; Cell Proliferation; Cytokines; Dermatitis; DNA; Imiquimod; Inflammation; Interleukin-22; Keratinocytes; Mice; Protein Kinases; Psoriasis; Skin

2023
PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes.
    Journal of molecular medicine (Berlin, Germany), 2023, Volume: 101, Issue:8

    Topics: Animals; Aromatase; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Psoriasis; RNA, Messenger; Skin

2023
Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis.
    Experimental dermatology, 2023, Volume: 32, Issue:10

    Topics: Animals; Disease Models, Animal; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Water

2023
Self-assembled Gallic acid loaded lecithin-chitosan hybrid nanostructured gel as a potential tool against imiquimod-induced psoriasis.
    Environmental research, 2023, 10-01, Volume: 234

    Topics: Chitosan; Gallic Acid; Humans; Imiquimod; Lecithins; Nanoparticles; Particle Size; Psoriasis

2023
RasGRP1 influences imiquimod-induced psoriatic inflammation via T-cell activation in mice.
    International immunopharmacology, 2023, Volume: 122

    Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Vascular Endothelial Growth Factor A

2023
An alkaloid-rich phytopharmaceutical prepared from Qing Dai against IL-17A-induced psoriasis.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt A

    Topics: Alkaloids; Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Quality of Life; Skin

2024
Gentiopicroside-Loaded Chitosan Nanoparticles Inhibit TNF-α-Induced Proliferation and Inflammatory Response in HaCaT Keratinocytes and Ameliorate Imiquimod-Induced Dermatitis Lesions in Mice.
    International journal of nanomedicine, 2023, Volume: 18

    Topics: Animals; Cell Proliferation; Chitosan; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Interleukin-6; Keratinocytes; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A

2023
IL-17A exacerbates psoriasis in a STAT3 overexpressing mouse model.
    PeerJ, 2023, Volume: 11

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-17; Mice; Psoriasis; Skin

2023
Qingre Lishi Decoction ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice by regulating the Treg-DC-Th17 axis and inhibiting MAPK-mediated DC maturation.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt A

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Psoriasis; Skin; Skin Diseases; T-Lymphocytes, Regulatory; Th17 Cells

2024
Evidence on the therapeutic role of thiolutin in imiquimod-induced psoriasis-like skin inflammation in mice.
    Immunity, inflammation and disease, 2023, Volume: 11, Issue:7

    Topics: Animals; Dermatitis; Forkhead Transcription Factors; Imiquimod; Inflammasomes; Inflammation; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis

2023
Characterization and active component identification of Premna herbacea roxb. root extract reveals anti-inflammatory effect and amelioration of imiquimod induced psoriasis via modulation of macrophage inflammatory response.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 119

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Macrophages; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Plant Extracts; Psoriasis; Skin

2023
Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis.
    The Journal of pathology, 2023, Volume: 261, Issue:2

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Integrin alpha Chains; Mice; Psoriasis; Skin

2023
Tranexamic acid improves psoriasis-like skin inflammation: Evidence from in vivo and in vitro studies.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 166

    Topics: Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Inflammasomes; Inflammation; Interleukin-17; Keratin-17; Keratinocytes; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Skin; Tranexamic Acid

2023
Resting-state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis-like skin lesions.
    Experimental dermatology, 2023, Volume: 32, Issue:11

    Topics: Animals; Anxiety; Brain; Humans; Imiquimod; Magnetic Resonance Imaging; Mice; Psoriasis

2023
Imiquimod-induced extensive plaque psoriasis.
    International journal of dermatology, 2023, Volume: 62, Issue:12

    Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease in mice.
    PloS one, 2023, Volume: 18, Issue:8

    Topics: Animals; Glycyrrhetinic Acid; Glycyrrhizic Acid; Imiquimod; Interleukin-17; Interleukin-23; Mice; Ointments; Psoriasis

2023
Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis.
    Cell death & disease, 2023, 09-07, Volume: 14, Issue:9

    Topics: Animals; Dermatitis; Disulfiram; Gasdermins; Imiquimod; Inflammation; Keratinocytes; Ki-67 Antigen; Mice; Psoriasis; Pyroptosis

2023
Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice.
    Chemical biology & drug design, 2023, Volume: 102, Issue:6

    Topics: Animals; Cannabidiol; Dietary Supplements; Disease Models, Animal; Erythema; Humans; Imiquimod; Inositol; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.
    Cell death & disease, 2023, 09-22, Volume: 14, Issue:9

    Topics: Animals; Dermatitis; Edar Receptor; Humans; Imiquimod; Keratinocytes; Mice; NF-kappa B; Psoriasis; Receptors, Ectodysplasin; Receptors, Tumor Necrosis Factor

2023
Dietary Fiber Inulin Improves Murine Imiquimod-Induced Psoriasis-like Dermatitis.
    International journal of molecular sciences, 2023, Sep-17, Volume: 24, Issue:18

    Topics: Animals; Dermatitis; Imiquimod; Interleukin-17; Inulin; Ki-67 Antigen; Mice; Propionates; Psoriasis; RNA, Ribosomal, 16S

2023
MicroRNA-125a-5p regulates the effect of Tregs on Th1 and Th17 through targeting ETS-1/STAT3 in psoriasis.
    Journal of translational medicine, 2023, 09-29, Volume: 21, Issue:1

    Topics: Animals; Cell Differentiation; Humans; Imiquimod; Mice; MicroRNAs; Psoriasis; STAT3 Transcription Factor; T-Lymphocytes, Regulatory; Th17 Cells

2023
Di-(2-ethylhexyl) phthalate aggravates psoriasis-like skin lesions: In vitro and in vivo evaluation.
    Toxicology and applied pharmacology, 2023, Nov-15, Volume: 479

    Topics: Animals; Diethylhexyl Phthalate; Humans; Imiquimod; Inflammation; Mice; p38 Mitogen-Activated Protein Kinases; Psoriasis; Skin; Skin Diseases

2023
Therapeutic effects of candesartan in inflammatory skin disorders by suppressing Th17 differentiation.
    International immunopharmacology, 2023, Volume: 124, Issue:Pt B

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Benzoates; Cell Differentiation; Dermatitis, Atopic; Humans; Imiquimod; PPAR gamma; Psoriasis; Skin; Telmisartan; Th17 Cells

2023
Design, synthesis and characterization of a novel multicomponent salt of bexarotene with metformin and application in ameliorating psoriasis with T2DM.
    International journal of pharmaceutics, 2023, Nov-05, Volume: 646

    Topics: Animals; Bexarotene; Diabetes Mellitus, Type 2; Drug Combinations; Humans; Imiquimod; Metformin; Mice; Psoriasis; Sodium Chloride; Tetrahydronaphthalenes

2023
Cannabidiol-Loaded Lipid-Stabilized Nanoparticles Alleviate Psoriasis Severity in Mice: A New Approach for Improved Topical Drug Delivery.
    Molecules (Basel, Switzerland), 2023, Oct-02, Volume: 28, Issue:19

    Topics: Animals; Cannabidiol; Disease Models, Animal; Emulsions; Imiquimod; Interleukin-17; Lipids; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; Rats; Skin

2023
Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression.
    Ecotoxicology and environmental safety, 2023, Nov-01, Volume: 266

    Topics: Animals; Biomarkers; Glucocorticoids; Humans; Imiquimod; Immunosuppression Therapy; Mice; Psoriasis; Skin; Toll-Like Receptor 7; Transcriptome; Zebrafish

2023
Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse.
    European journal of pharmacology, 2023, Dec-05, Volume: 960

    Topics: Animals; B7-H1 Antigen; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Imiquimod; Immune Checkpoint Inhibitors; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Pruritus; Psoriasis; Spinal Cord Dorsal Horn

2023
Topical anti-TNF-a ssDNA aptamer decreased the imiquimod induced psoriatic inflammation in BALB/c mice.
    Cytokine, 2023, Volume: 172

    Topics: Animals; Disease Models, Animal; DNA, Single-Stranded; Imiquimod; Inflammation; Interleukin-17; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger; Skin; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha

2023
Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor 1 Antagonists for the Treatment of Psoriasis.
    Journal of medicinal chemistry, 2023, 11-09, Volume: 66, Issue:21

    Topics: Animals; Chemokines; Cricetinae; Cricetulus; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
Development of a Deep Eutectic Solvent-Assisted Kaempferol Hydrogel: A Promising Therapeutic Approach for Psoriasis-like Skin Inflammation.
    Molecular pharmaceutics, 2023, Dec-04, Volume: 20, Issue:12

    Topics: Animals; Antioxidants; Deep Eutectic Solvents; Disease Models, Animal; Hydrogels; Imiquimod; Inflammation; Kaempferols; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2023
Quality-by-Design Approach for Investigating the Efficacy of Tacrolimus and Hyaluronic Acid-Loaded Ethosomal Gel in Dermal Management of Psoriasis: In Vitro, Ex Vivo, and In Vivo Evaluation.
    AAPS PharmSciTech, 2023, Nov-01, Volume: 24, Issue:8

    Topics: Administration, Cutaneous; Humans; Hyaluronic Acid; Imiquimod; Psoriasis; Skin; Tacrolimus

2023
Preparation and characterization of solid lipid nanoparticles encapsulated noscapine and evaluation of its protective effects against imiquimod-induced psoriasis-like skin lesions.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 168

    Topics: Humans; Imiquimod; Inflammation; Lipids; Nanoparticles; Noscapine; Psoriasis; Skin

2023
LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice.
    Allergologia et immunopathologia, 2023, Volume: 51, Issue:6

    Topics: Animals; Cytokines; Imiquimod; Mice; Mice, Inbred C57BL; Psoriasis; Sirtuin 1; Th17 Cells

2023
Characterization of spinal microglial activation in a mouse model of imiquimod-induced psoriasis.
    Journal of pharmacological sciences, 2023, Volume: 153, Issue:4

    Topics: Animals; Disease Models, Animal; Imiquimod; Mice; Microglia; Pruritus; Psoriasis; Spinal Cord

2023
Staphylococcus warneri strain XSB102 exacerbates psoriasis and promotes keratinocyte proliferation in imiquimod-induced psoriasis-like dermatitis mice.
    Archives of microbiology, 2023, Nov-22, Volume: 206, Issue:1

    Topics: Animals; Cell Proliferation; Dermatitis; Disease Models, Animal; Homeodomain Proteins; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Repressor Proteins; Skin; Staphylococcus

2023
Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments.
    BMC research notes, 2023, Nov-25, Volume: 16, Issue:1

    Topics: Animals; Antipruritics; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred C57BL; Pruritus; Psoriasis; Rats; Rats, Wistar; Skin

2023
Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation.
    Scientific reports, 2019, 08-12, Volume: 9, Issue:1

    Topics: Animals; Antibodies, Neutralizing; CD4-Positive T-Lymphocytes; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Interleukin-7; Lymph Nodes; Lymphatic Vessels; Male; Mice; Mice, Inbred C57BL; Organ Specificity; Oxazolone; Psoriasis; Receptors, Interleukin-7; Signal Transduction; Skin; Tetradecanoylphorbol Acetate

2019
Kaempferol attenuates imiquimod-induced psoriatic skin inflammation in a mouse model.
    Clinical and experimental immunology, 2019, Volume: 198, Issue:3

    Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-6; Kaempferols; Mice, Inbred BALB C; Psoriasis; Signal Transduction; Skin

2019
Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model.
    International journal of pharmaceutics, 2019, Oct-05, Volume: 569

    Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Female; Folic Acid Antagonists; Imiquimod; Immunosuppressive Agents; Liposomes; Methotrexate; Mice, Inbred BALB C; Psoriasis

2019
Targeting the IL-17 Receptor Using Liposomal Spherical Nucleic Acids as Topical Therapy for Psoriasis.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:2

    Topics: Administration, Cutaneous; Animals; Biomarkers; Cells, Cultured; Disease Models, Animal; DNA, Antisense; Gene Knockdown Techniques; Humans; Imiquimod; Keratinocytes; Liposomes; Mice; Nanospheres; Primary Cell Culture; Psoriasis; Receptors, Interleukin-17; RNA, Messenger; Severity of Illness Index; Skin

2020
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
    Nature immunology, 2019, Volume: 20, Issue:9

    Topics: A549 Cells; Animals; Antibodies, Blocking; Antibodies, Monoclonal; Cell Line, Tumor; Disease Models, Animal; HEK293 Cells; Humans; Imiquimod; Inflammation; Interleukin-1; Interleukin-1 Receptor Accessory Protein; Interleukin-1beta; Interleukin-33; Male; Mice; Mice, Inbred C57BL; Ovalbumin; Peritonitis; Pneumonia; Psoriasis; Signal Transduction; Uric Acid

2019
Artesunate alleviates imiquimod-induced psoriasis-like dermatitis in BALB/c mice.
    International immunopharmacology, 2019, Volume: 75

    Topics: Animals; Anti-Inflammatory Agents; Artesunate; Dermatitis; Imiquimod; Intraepithelial Lymphocytes; Lymph Nodes; Male; Mice, Inbred BALB C; Psoriasis; Skin; Th17 Cells

2019
Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Adult; Animals; Blood Platelets; Humans; Imiquimod; Mice; Mice, Inbred C57BL; Neutrophils; Platelet Activation; Platelet Aggregation; Platelet Count; Psoriasis; Skin

2019
Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-κB/AP-1 activation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 119

    Topics: Administration, Cutaneous; Animals; Cell Line; Drug Delivery Systems; Humans; Imiquimod; Indoles; Male; Methanol; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; NF-kappa B; Nitrobenzenes; Phosphorylation; Psoriasis; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2019
Ginsenoside Rg1 abolish imiquimod-induced psoriasis-like dermatitis in BALB/c mice via downregulating NF-κB signaling pathway.
    Journal of food biochemistry, 2019, Volume: 43, Issue:11

    Topics: Animals; Dermatitis; Disease Models, Animal; Down-Regulation; Ginsenosides; Humans; Imiquimod; Interleukin-22; Interleukin-23; Interleukins; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2019
[Esculentoside reduces expression of Th17 cell-related cytokines in the imiquimod-induced psoriasis-like dermatitis mouse model].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2019, Volume: 35, Issue:7

    Topics: Animals; Cytokines; Dermatitis; Female; Imiquimod; Mice; Mice, Inbred BALB C; Oleanolic Acid; Psoriasis; Random Allocation; Saponins; Skin; Th17 Cells

2019
Kan-Lu-Hsiao-Tu-Tan, a traditional Chinese medicine formula, inhibits human neutrophil activation and ameliorates imiquimod-induced psoriasis-like skin inflammation.
    Journal of ethnopharmacology, 2020, Jan-10, Volume: 246

    Topics: Animals; Cells, Cultured; Drugs, Chinese Herbal; Humans; Imiquimod; Inflammation; Male; Medicine, Chinese Traditional; Mice; Neutrophil Activation; Neutrophils; Psoriasis

2020
The Influence of Ketogenic Diets on Psoriasiform-Like Skin Inflammation.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:3

    Topics: 3-Hydroxybutyric Acid; Animals; Biopsy; Blood Glucose; Diet, Ketogenic; Disease Models, Animal; Fatty Acids, Omega-3; Humans; Imiquimod; Male; Mice; Psoriasis; Severity of Illness Index; Skin; Triglycerides; Weight Gain

2020
Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis.
    Scientific reports, 2019, 10-28, Volume: 9, Issue:1

    Topics: Animals; Cytokines; Disease Models, Animal; Imiquimod; Male; Mice; Mice, Inbred BALB C; Peptides; Psoriasis; RANK Ligand

2019
Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:5

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Gold; Humans; Imiquimod; Immunity; Methotrexate; Mice; Mice, Inbred C57BL; Nanoparticles; Psoriasis; Skin; Th17 Cells; Xenograft Model Antitumor Assays

2020
Biological depletion of neutrophils attenuates pro-inflammatory markers and the development of the psoriatic phenotype in a murine model of psoriasis.
    Clinical immunology (Orlando, Fla.), 2020, Volume: 210

    Topics: Animals; Biomarkers; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Leukocyte Reduction Procedures; Mice; Mice, Inbred BALB C; Neutrophils; Phenotype; Psoriasis

2020
D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2019, Volume: 38, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Imiquimod; Inflammation; Inositol; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis

2019
Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 121

    Topics: Animals; Disease Models, Animal; Female; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Necroptosis; Protein Kinases; Psoriasis; Reactive Oxygen Species; Skin; Strophanthins

2020
Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis.
    Experimental dermatology, 2020, Volume: 29, Issue:1

    Topics: Animals; Cell Line; Cell Proliferation; Cytokines; Disease Models, Animal; Gene Expression; Humans; Imiquimod; Inflammation; Interleukin-6; Keratinocytes; Male; Mice; Mice, Knockout; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Psoriasis; RNA, Messenger; Severity of Illness Index; Th17 Cells; TRPV Cation Channels

2020
Calcipotriol and betamethasone dipropionate exhibit different immunomodulatory effects on imiquimod-induced murine psoriasiform dermatitis.
    The Journal of dermatology, 2020, Volume: 47, Issue:2

    Topics: Administration, Cutaneous; Animals; Betamethasone; Calcitriol; Cytokines; Dermatologic Agents; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Gene Expression Regulation; Glucocorticoids; Humans; Imiquimod; Mice; Ointments; Psoriasis; Skin; Th1 Cells; Th17 Cells

2020
Topical administration of nanocarrier miRNA-210 antisense ameliorates imiquimod-induced psoriasis-like dermatitis in mice.
    The Journal of dermatology, 2020, Volume: 47, Issue:2

    Topics: Administration, Cutaneous; Animals; Antagomirs; Disease Models, Animal; Drug Carriers; Female; Gels; Humans; Imiquimod; Lipoproteins, HDL; Mice; MicroRNAs; Nanoparticles; Psoriasis; Skin; Th1 Cells; Th17 Cells

2020
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
    Life sciences, 2020, Jan-15, Volume: 241

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line; Cell Proliferation; Cytokines; Diosgenin; Disease Models, Animal; Female; Human Umbilical Vein Endothelial Cells; Humans; Imiquimod; Keratinocytes; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Receptors, Interleukin

2020
Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis.
    BMC complementary and alternative medicine, 2019, Dec-02, Volume: 19, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dictamnus; Female; Imiquimod; Mice; Mice, Inbred C57BL; Plant Bark; Plant Extracts; Psoriasis; Skin; STAT3 Transcription Factor; T-Lymphocytes, Helper-Inducer

2019
CD200-CD200R1 signalling attenuates imiquimod-induced psoriatic inflammation by inhibiting the activation of skin inflammatory macrophages.
    International immunopharmacology, 2020, Volume: 78

    Topics: Animals; Antigens, CD; Cell Movement; Cells, Cultured; Coculture Techniques; Humans; Imiquimod; Interleukin-1beta; Interleukin-6; Keratinocytes; Macrophages; Male; Mice; NF-kappa B; Orexin Receptors; Primary Cell Culture; Psoriasis; Signal Transduction; Skin

2020
Acitretin inhibits IL-17A-induced IL-36 expression in keratinocytes by down-regulating IκBζ.
    International immunopharmacology, 2020, Volume: 79

    Topics: Acitretin; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Down-Regulation; Female; Humans; I-kappa B Kinase; Imiquimod; Interleukin-1; Interleukin-17; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis

2020
Mechanism of danshensu-induced inhibition of abnormal epidermal proliferation in psoriasis.
    European journal of pharmacology, 2020, Feb-05, Volume: 868

    Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Animals; Apoptosis; Cell Cycle Proteins; Cell Line; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epidermis; Female; G1 Phase Cell Cycle Checkpoints; Humans; Imiquimod; Injections, Intraperitoneal; Keratinocytes; Lactates; Mice; Psoriasis; Salvia miltiorrhiza; Transcription Factors; YAP-Signaling Proteins

2020
Tussilagonone Ameliorates Psoriatic Features in Keratinocytes and Imiquimod-Induced Psoriasis-Like Lesions in Mice via NRF2 Activation.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:6

    Topics: Administration, Cutaneous; Adult; Animals; Anti-Inflammatory Agents; Cell Line; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Imiquimod; Keratinocytes; Mice; NF-E2-Related Factor 2; Pentanoic Acids; Psoriasis; Sesquiterpenes; Tussilago

2020
Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases.
    European journal of medicinal chemistry, 2020, Feb-01, Volume: 187

    Topics: Animals; Cell Differentiation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; Fluorescence Resonance Energy Transfer; Imiquimod; Mice; Mice, Inbred BALB C; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Quinolines; Structure-Activity Relationship; Sulfonamides; Th17 Cells

2020
Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2/STAT3 signal pathways.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 123

    Topics: Animals; Cell Line; Cell Proliferation; Cyclosporine; Cytokines; Dermatitis; Humans; Imiquimod; Inflammation; Janus Kinase 2; Keratinocytes; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Models, Animal; Psoriasis; Quercetin; Receptor, Notch1; Signal Transduction; Skin; STAT3 Transcription Factor; T-Lymphocytes; Transcription Factors

2020
PSORI-CM02 formula alleviates imiquimod-induced psoriasis via affecting macrophage infiltration and polarization.
    Life sciences, 2020, Feb-15, Volume: 243

    Topics: Adjuvants, Immunologic; Animals; Cell Differentiation; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Imiquimod; Macrophages; Mice; Psoriasis; RAW 264.7 Cells; RNA, Messenger; Skin

2020
Aryl Hydrocarbon Receptor in Cutaneous Vascular Endothelial Cells Restricts Psoriasis Development by Negatively Regulating Neutrophil Recruitment.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:6

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Biopsy; Disease Models, Animal; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Female; Humans; Imiquimod; Intercellular Adhesion Molecule-1; Interleukin-23; Male; Mice; Mice, Knockout; Neutrophil Infiltration; Psoriasis; Receptors, Aryl Hydrocarbon; Skin

2020
Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation.
    Cell death & disease, 2020, 01-10, Volume: 11, Issue:1

    Topics: Animals; Apoptosis; Cell Proliferation; Chemokines; Dioxolanes; Epidermis; Epigenesis, Genetic; HaCaT Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Imiquimod; Inflammation; Keratin-17; Keratinocytes; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Models, Biological; Phosphorylation; Protein Binding; Psoriasis; RAW 264.7 Cells; Skin; STAT3 Transcription Factor

2020
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Regulates Epidermal Keratinization under Psoriatic Skin Inflammation.
    The American journal of pathology, 2020, Volume: 190, Issue:3

    Topics: Animals; Cell Differentiation; Cells, Cultured; Chimera; Epidermis; Female; Homeostasis; Humans; Imiquimod; Immunohistochemistry; Inflammation; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Parakeratosis; Psoriasis; Skin

2020
Effects of tumor necrosis factor-like ligand 1A (TL1A) on imiquimod-induced psoriasiform skin inflammation in mice.
    Archives of dermatological research, 2020, Volume: 312, Issue:7

    Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Male; Mice; Psoriasis; Signal Transduction; Skin; Tumor Necrosis Factor Ligand Superfamily Member 15; Tumor Necrosis Factor-alpha

2020
Bruton's tyrosine kinase inhibitor suppresses imiquimod-induced psoriasis-like inflammation in mice through regulation of IL-23/IL-17A in innate immune cells.
    International immunopharmacology, 2020, Volume: 80

    Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Immunity, Innate; Interleukin-17; Interleukin-23; Intraepithelial Lymphocytes; Male; Mice; Piperidines; Protein Kinase Inhibitors; Psoriasis; Pyrazoles; Pyrimidines; Signal Transduction; Skin

2020
4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.
    Journal of immunology (Baltimore, Md. : 1950), 2020, 04-01, Volume: 204, Issue:7

    Topics: 4-1BB Ligand; Animals; Cell Line; Female; Imiquimod; Inflammation; Interleukin-17; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Psoriasis; RAW 264.7 Cells; Signal Transduction; Skin; T-Lymphocytes, Regulatory

2020
Diet-induced obesity exacerbates imiquimod-mediated psoriasiform dermatitis in anti-PD-1 antibody-treated mice: Implications for patients being treated with checkpoint inhibitors for cancer.
    Journal of dermatological science, 2020, Volume: 97, Issue:3

    Topics: Animals; Diet, Western; Disease Models, Animal; Female; Humans; Imiquimod; Immune Checkpoint Inhibitors; Mice; Neoplasms; Obesity; Programmed Cell Death 1 Receptor; Psoriasis; Risk Factors; Skin; Symptom Flare Up

2020
PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation.
    International journal of molecular sciences, 2020, Feb-12, Volume: 21, Issue:4

    Topics: Animals; beta Catenin; Cytokines; Disease Models, Animal; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; NF-kappa B; Polydeoxyribonucleotides; Psoriasis; Receptor, Adenosine A2A; Skin; Wnt Signaling Pathway

2020
Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis.
    Drug delivery and translational research, 2020, Volume: 10, Issue:3

    Topics: Administration, Cutaneous; Animals; Delayed-Action Preparations; Disease Models, Animal; Down-Regulation; Drug Synergism; Female; Imiquimod; Liposomes; Male; Mice; Mice, Inbred BALB C; Nanoparticles; NIH 3T3 Cells; Particle Size; Psoriasis; RNA, Small Interfering; Tacrolimus; Tumor Necrosis Factor-alpha

2020
Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation.
    Cell death & disease, 2020, 02-19, Volume: 11, Issue:2

    Topics: Acrylamides; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Female; HaCaT Cells; Humans; Imidazoles; Imiquimod; Indoles; Inflammation Mediators; Keratinocytes; Mice, Inbred BALB C; Necroptosis; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Psoriasis; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Skin; Sulfonamides

2020
Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides.
    Scientific reports, 2020, 02-19, Volume: 10, Issue:1

    Topics: Animals; Antimicrobial Cationic Peptides; Chemokine CCL20; Disease Models, Animal; Down-Regulation; Epidermis; Flavonoids; Humans; Hyperplasia; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukins; Keratinocytes; Male; MAP Kinase Signaling System; Mice, Inbred BALB C; NF-kappa B; Phosphorylation; Psoriasis; RNA, Messenger; Skin; Tumor Necrosis Factor-alpha

2020
Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice.
    Life science alliance, 2020, Volume: 3, Issue:4

    Topics: Animals; Cytokines; Dermatitis; Female; Humans; Imiquimod; Inflammation; Intraepithelial Lymphocytes; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Psoriasis; Receptors, Interleukin-1; Skin

2020
Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.
    International journal of molecular sciences, 2020, Feb-25, Volume: 21, Issue:5

    Topics: Animals; GTP-Binding Proteins; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Protein Glutamine gamma Glutamyltransferase 2; Psoriasis; Transglutaminases

2020
Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide.
    Journal of immunology (Baltimore, Md. : 1950), 2020, 04-15, Volume: 204, Issue:8

    Topics: Animals; Autoimmune Diseases; Female; Gene Silencing; Imidazoles; Imiquimod; Interleukin-23 Subunit p19; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; Nylons; Psoriasis; Pyrroles; Uveitis

2020
Development of flavanone and its derivatives as topical agents against psoriasis: The prediction of therapeutic efficiency through skin permeation evaluation and cell-based assay.
    International journal of pharmaceutics, 2020, May-15, Volume: 581

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Female; Flavanones; Humans; Imiquimod; Keratinocytes; Mice; Models, Biological; Models, Molecular; Permeability; Psoriasis; Skin; Skin Absorption; Specific Pathogen-Free Organisms; Structure-Activity Relationship; Swine; Water Loss, Insensible

2020
Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells.
    European journal of pharmacology, 2020, Jun-15, Volume: 877

    Topics: Adenine; Animals; BALB 3T3 Cells; Dendritic Cells; Down-Regulation; Imiquimod; Inflammation Mediators; Male; Mice; Neutrophils; Oxidation-Reduction; Oxidative Stress; Peroxidase; Piperidines; Psoriasis; Signal Transduction; Skin

2020
Albendazole negatively regulates keratinocyte proliferation.
    Clinical science (London, England : 1979), 2020, 04-17, Volume: 134, Issue:7

    Topics: Albendazole; Animals; cdc25 Phosphatases; Cell Line; Cell Proliferation; Cytokines; Dermatologic Agents; Disease Models, Animal; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Humans; Imiquimod; Inflammation Mediators; Keratinocytes; Keratins; Male; Mice, Inbred C57BL; Phosphorylation; Psoriasis; S Phase Cell Cycle Checkpoints; Signal Transduction; Skin

2020
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
    Communications biology, 2020, 04-03, Volume: 3, Issue:1

    Topics: A549 Cells; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; Female; HEK293 Cells; HeLa Cells; Humans; Imiquimod; Immunity, Innate; Inflammation Mediators; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred BALB C; Molecular Structure; Psoriasis; Signal Transduction; Structure-Activity Relationship; Transcription Factors; Ubiquitin-Protein Ligases; Ubiquitins

2020
Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2020, Volume: 72, Issue:9

    Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Arthritis, Experimental; Arthritis, Psoriatic; CD4-Positive T-Lymphocytes; Cell Differentiation; Collagen Type II; Disease Models, Animal; Imiquimod; Interleukin-17; Interleukin-2; Mannans; Membrane Proteins; Mice; Mice, Knockout; Psoriasis; Saccharomyces cerevisiae; Skin; T-Lymphocytes, Regulatory; Th17 Cells; Transforming Growth Factor beta

2020
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.
    Biochemical pharmacology, 2020, Volume: 177

    Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Humans; Imiquimod; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; Phosphodiesterase 4 Inhibitors; Psoriasis; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction

2020
Interleukin-33 alleviates psoriatic inflammation by suppressing the T helper type 17 immune response.
    Immunology, 2020, Volume: 160, Issue:4

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Humans; Imiquimod; Immune Tolerance; Immunity, Cellular; Inflammation; Interleukin-17; Interleukin-33; Mice; Mice, Inbred C57BL; Psoriasis; Skin; Th17 Cells

2020
Differential Effects of Biologics on Psoriasis-Related Vascular Inflammation and Risk of Thrombosis.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:11

    Topics: Animals; Biological Products; Cell Communication; Endothelial Cells; Humans; Imiquimod; Leukocytes; Mice; Psoriasis; Thrombosis; Tumor Necrosis Factor-alpha; Vasculitis

2020
Combination Therapy of Acarbose and Cyclosporine a Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice.
    Molecules (Basel, Switzerland), 2020, Apr-16, Volume: 25, Issue:8

    Topics: Acarbose; Animals; Anti-Inflammatory Agents; Cyclosporine; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Gene Expression Regulation; Humans; Imiquimod; Male; Mice; Psoriasis; T-Lymphocytes, Regulatory; Tumor Necrosis Factor-alpha

2020
IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.
    Life science alliance, 2020, Volume: 3, Issue:6

    Topics: Administration, Cutaneous; Animals; Drug Eruptions; Female; Gene Deletion; Imiquimod; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Otitis Externa; Psoriasis; Receptors, Interleukin-1; Signal Transduction

2020
Estrogen receptor α activation aggravates imiquimod-induced psoriasis-like dermatitis in mice by enhancing dendritic cell interleukin-23 secretion.
    Journal of applied toxicology : JAT, 2020, Volume: 40, Issue:10

    Topics: Animals; Dendritic Cells; Estrogen Receptor alpha; Humans; Imiquimod; Inflammation; Interleukin-23; Male; Mice; Models, Animal; Pruritus; Psoriasis

2020
Heptapeptide HP3 acts as a potent inhibitor of experimental imiquimod‑induced murine psoriasis and impedes the trans‑endothelial migration of mononuclear cells.
    Molecular medicine reports, 2020, Volume: 22, Issue:1

    Topics: Animals; Cell Line; Disease Models, Animal; Endothelial Cells; Female; Humans; Imiquimod; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Oligopeptides; Psoriasis; Transendothelial and Transepithelial Migration

2020
Immune Modulation of Monocytes Dampens the IL-17
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:12

    Topics: Animals; Antigens, Ly; Disease Models, Animal; Humans; Imiquimod; Immunologic Factors; Interleukin-17; Interleukin-1beta; Interleukin-23; Intraepithelial Lymphocytes; Macrophages; Male; Mice; Monocytes; Psoriasis; Severity of Illness Index; Skin

2020
The Role of Gut Microbiome in Psoriasis: Oral Administration of
    International journal of molecular sciences, 2020, May-07, Volume: 21, Issue:9

    Topics: Administration, Oral; Animals; Animals, Genetically Modified; Cytokines; Disease Models, Animal; Feces; Female; Gastrointestinal Microbiome; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Mice; Psoriasis; RNA, Ribosomal, 16S; Staphylococcus aureus; Streptococcus; Tumor Necrosis Factor-alpha; Up-Regulation

2020
Spleen and thymus metabolomics strategy to explore the immunoregulatory mechanism of total withanolides from the leaves of Datura metel L. on imiquimod-induced psoriatic skin dermatitis in mice.
    Biomedical chromatography : BMC, 2020, Volume: 34, Issue:9

    Topics: Animals; Datura metel; Disease Models, Animal; Imiquimod; Immunosuppressive Agents; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Plant Extracts; Plant Leaves; Psoriasis; Spleen; Thymus Gland; Withanolides

2020
Ozone Therapy Attenuates NF-κB-Mediated Local Inflammatory Response and Activation of Th17 Cells in Treatment for Psoriasis.
    International journal of biological sciences, 2020, Volume: 16, Issue:11

    Topics: Administration, Topical; Animals; Baths; CD4-Positive T-Lymphocytes; Female; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; NF-kappa B; Oils; Ozone; Psoriasis; Severity of Illness Index; Th17 Cells; Toll-Like Receptor 2

2020
Stress aggravates and prolongs imiquimod-induced psoriasis-like epidermal hyperplasis and IL-1β/IL-23p40 production.
    Journal of leukocyte biology, 2020, Volume: 108, Issue:1

    Topics: Animals; Anxiety; Dendritic Cells; Dermatitis; Emotions; Epidermis; Hyperplasia; Imiquimod; Inflammation; Interleukin-12 Subunit p40; Interleukin-1beta; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Nociceptors; Psoriasis; Receptors, Neurokinin-1; Stress, Psychological; Substance P; Up-Regulation

2020
Local reinfusion of B10 cells is effective in the treatment of pustular psoriasis.
    Dermatologic therapy, 2020, Volume: 33, Issue:4

    Topics: Autoimmune Diseases; Cell Differentiation; Humans; Imiquimod; Psoriasis; Skin

2020
Regulatory T cells suppress skin inflammation in the imiquimod-induced psoriasis-like mouse model.
    Journal of dermatological science, 2020, Volume: 98, Issue:3

    Topics: Animals; Dermatitis, Contact; Disease Models, Animal; Humans; Imiquimod; Interleukin-2 Receptor alpha Subunit; Intraepithelial Lymphocytes; Lymphocyte Depletion; Mice; Psoriasis; Severity of Illness Index; Skin; T-Lymphocytes, Regulatory; Time Factors

2020
Notch-Hes1 Signaling Regulates IL-17A
    Mediators of inflammation, 2020, Volume: 2020

    Topics: Animals; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Imiquimod; Inflammation; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Psoriasis; Receptors, Notch; Signal Transduction; Skin; Spleen; T-Lymphocytes; Th17 Cells; Transcription Factor HES-1

2020
Exacerbated Imiquimod-Induced Psoriasis-Like Skin Inflammation in IRF5-Deficient Mice.
    International journal of molecular sciences, 2020, May-23, Volume: 21, Issue:10

    Topics: Animals; Cells, Cultured; Dendritic Cells; Female; Imiquimod; Interferon Inducers; Interferon Regulatory Factors; Interferons; Interleukins; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; Psoriasis; Skin; Th17 Cells

2020
Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice.
    International journal of molecular medicine, 2020, Volume: 46, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Psoriasis; Reverse Transcriptase Polymerase Chain Reaction

2020
Design & development of nanosponge loaded topical gel of curcumin and caffeine mixture for augmented treatment of psoriasis.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2020, Volume: 28, Issue:2

    Topics: Administration, Topical; Animals; beta-Cyclodextrins; Caffeine; Curcumin; Delayed-Action Preparations; Disease Models, Animal; Drug Combinations; Drug Compounding; Female; Formates; Imiquimod; Male; Mice; Nanostructures; Particle Size; Psoriasis

2020
18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice.
    BMC pharmacology & toxicology, 2020, 06-03, Volume: 21, Issue:1

    Topics: Animals; Apoptosis; Cell Line; Cytokines; Female; Glycyrrhetinic Acid; Humans; Imiquimod; Keratinocytes; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Reactive Oxygen Species; Signal Transduction; Skin

2020
Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway.
    Bioscience reports, 2020, 06-26, Volume: 40, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chromones; Cytokines; Disease Models, Animal; HaCaT Cells; Humans; Imiquimod; Intercellular Adhesion Molecule-1; Keratinocytes; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Oxidative Stress; Phosphorylation; Psoriasis; Signal Transduction; Skin

2020
Topical application of endothelin receptor a antagonist attenuates imiquimod-induced psoriasiform skin inflammation.
    Scientific reports, 2020, 06-11, Volume: 10, Issue:1

    Topics: Administration, Topical; Animals; Cytokines; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression Regulation; Humans; Imiquimod; Mice; Phenylpropionates; Psoriasis; Pyridazines; Receptors, Endothelin; Skin

2020
Complement component 3 prevents imiquimod-induced psoriatic skin inflammation by inhibiting apoptosis in mice.
    International immunopharmacology, 2020, Volume: 85

    Topics: Animals; Apoptosis; Complement C3; Cytokines; Female; Imiquimod; Inflammation; Interleukin-17; Male; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; T-Lymphocytes

2020
2'-fucosyllactose inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response via the STAT3 signaling pathway.
    International immunopharmacology, 2020, Volume: 85

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Female; Imiquimod; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Signal Transduction; Skin; STAT3 Transcription Factor; Th17 Cells; Trisaccharides

2020
C5a/C5aR1 mediates IMQ-induced psoriasiform skin inflammation by promoting IL-17A production from γδ-T cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:8

    Topics: Animals; Cytokines; Down-Regulation; Female; Gene Expression; Imiquimod; Inflammation; Interleukin-17; Intraepithelial Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Psoriasis; Receptor, Anaphylatoxin C5a; Signal Transduction; Skin

2020
Therapeutic anti-psoriatic effects of myeloid-derived suppressor cells in combination with systemic tacrolimus (FK-506) in an imiquimod-induced mouse model of psoriasis.
    International immunopharmacology, 2020, Volume: 86

    Topics: Animals; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Female; Imiquimod; Immunomodulation; Immunosuppressive Agents; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Psoriasis; Skin; Spleen; T-Lymphocytes, Regulatory; Tacrolimus; Th1 Cells; Th17 Cells

2020
Anti-psoriatic properties of paeoniflorin: suppression of the NF-kappaB pathway and Keratin 17.
    European journal of dermatology : EJD, 2020, Jun-01, Volume: 30, Issue:3

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cytokines; Down-Regulation; Female; Glucosides; HaCaT Cells; Humans; Imiquimod; Keratin-17; Keratinocytes; Keratins; Mice; Monoterpenes; NF-kappa B; Psoriasis; Signal Transduction

2020
Chronic Alcohol Consumption Exacerbates the Severity of Psoriasiform Dermatitis in Mice.
    Alcoholism, clinical and experimental research, 2020, Volume: 44, Issue:9

    Topics: Alcohol Drinking; Animals; Central Nervous System Depressants; Chemokine CCL20; Ethanol; Gene Expression Profiling; Imiquimod; Interferon Inducers; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Keratinocytes; Mice; Psoriasis; Skin; Th17 Cells

2020
310 nm UV-LEDs attenuate imiquimod-induced psoriasis-like skin lesions in C57BL/6 mice and inhibit IL-22-induced STAT3 expression in HaCaT cells.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2020, Aug-01, Volume: 19, Issue:8

    Topics: Animals; Antineoplastic Agents; HaCaT Cells; Humans; Imiquimod; Inflammation; Interleukin-22; Interleukins; Mice; Mice, Inbred C57BL; Psoriasis; Skin; STAT3 Transcription Factor; Ultraviolet Rays

2020
An Anti-Inflammatory Poly(PhosphorHydrazone) Dendrimer Capped with AzaBisPhosphonate Groups to Treat Psoriasis.
    Biomolecules, 2020, 06-23, Volume: 10, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Dendrimers; Diphosphonates; Disease Models, Animal; Hydrazones; Imiquimod; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Polymers; Psoriasis

2020
Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome.
    Molecular metabolism, 2020, Volume: 41

    Topics: Animals; Cell Proliferation; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Prediabetic State; Psoriasis; Skin

2020
Co-Delivery of Imiquimod and Curcumin by Nanoemugel for Improved Topical Delivery and Reduced Psoriasis-Like Skin Lesions.
    Biomolecules, 2020, 06-27, Volume: 10, Issue:7

    Topics: Administration, Topical; Animals; Curcumin; Disease Models, Animal; Drug Combinations; Drug Compounding; Emulsions; Imiquimod; Male; Mice; Mice, Inbred BALB C; Nanogels; Oleic Acid; Particle Size; Permeability; Polyethylene Glycols; Polyethyleneimine; Polysorbates; Psoriasis; Rats

2020
Facile skin targeting of a thalidomide analog containing benzyl chloride moiety alleviates experimental psoriasis via the suppression of MAPK/NF-κB/AP-1 phosphorylation in keratinocytes.
    Journal of dermatological science, 2020, Volume: 99, Issue:2

    Topics: Administration, Cutaneous; Animals; Disease Models, Animal; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Male; MAP Kinase Signaling System; Mice; NF-kappa B; Phosphorylation; Psoriasis; Skin; Thalidomide; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2020
Anti-psoriatic effect of Lavandula angustifolia essential oil and its major components linalool and linalyl acetate.
    Journal of ethnopharmacology, 2020, Oct-28, Volume: 261

    Topics: Acyclic Monoterpenes; Administration, Cutaneous; Animals; Cytokines; Dermatologic Agents; Disease Models, Animal; Female; Imiquimod; Inflammation Mediators; Lavandula; Mice, Inbred BALB C; Monoterpenes; Oils, Volatile; Plant Oils; Psoriasis; Rabbits; Signal Transduction; Skin

2020
Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:2

    Topics: Acetylation; Animals; Disease Models, Animal; Down-Regulation; Humans; Imiquimod; Male; Mice; Mice, Knockout; Phosphorylation; Psoriasis; Pyruvate Kinase; Sirtuin 2; Skin; STAT3 Transcription Factor; Th17 Cells

2021
Hispidulin alleviates imiquimod-induced psoriasis-like skin inflammation by inhibiting splenic Th1/Th17 cell population and keratinocyte activation.
    International immunopharmacology, 2020, Volume: 87

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Female; Flavones; Humans; Imiquimod; Keratinocytes; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Neutrophils; NF-kappa B; Psoriasis; Spleen; Th1 Cells; Th17 Cells

2020
Delivery and Anti-Psoriatic Effect of Silibinin-Loaded Polymeric Micelles: An Experimental Study in the Psoriatic Skin Model.
    Current drug delivery, 2020, Volume: 17, Issue:9

    Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Liberation; Female; Humans; Imiquimod; Mice; Micelles; Nanoparticles; Particle Size; Polymers; Psoriasis; Signal Transduction; Silybin; Skin; Skin Absorption; STAT3 Transcription Factor

2020
Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model.
    Molecular medicine reports, 2020, Volume: 22, Issue:3

    Topics: Animals; CCAAT-Enhancer-Binding Protein-delta; Cell Proliferation; Disease Models, Animal; Down-Regulation; HaCaT Cells; Humans; Imiquimod; Interleukin-17; Interleukin-6; Mice; Naphthoquinones; Psoriasis; Signal Transduction; STAT3 Transcription Factor

2020
Uncovering the mechanism of Jueyin granules in the treatment of psoriasis using network pharmacology.
    Journal of ethnopharmacology, 2020, Nov-15, Volume: 262

    Topics: Animals; Cell Proliferation; Drugs, Chinese Herbal; Imiquimod; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Psoriasis; Treatment Outcome

2020
    International journal of molecular sciences, 2020, Aug-01, Volume: 21, Issue:15

    Topics: Animals; Cytokines; Dermatitis; Female; Gene Expression Regulation; Imiquimod; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukin-17; Interleukin-23 Subunit p19; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Tumor Necrosis Factor-alpha

2020
Methotrexate-Loaded Nanostructured Lipid Carrier Gel Alleviates Imiquimod-Induced Psoriasis by Moderating Inflammation: Formulation, Optimization, Characterization, In-Vitro and In-Vivo Studies.
    International journal of nanomedicine, 2020, Volume: 15

    Topics: Administration, Cutaneous; Administration, Topical; Animals; Catalase; Cytokines; Drug Carriers; Drug Compounding; Drug Liberation; Gels; Glutathione; Humans; Imiquimod; Inflammation; Lipids; Malondialdehyde; Methotrexate; Mice, Inbred BALB C; Nanostructures; Organ Size; Psoriasis; Superoxide Dismutase

2020
A Localized Aldara (5% Imiquimod)-Induced Psoriasiform Dermatitis Model in Mice Using Finn Chambers.
    Current protocols in pharmacology, 2020, Volume: 90, Issue:1

    Topics: Animals; Dermatitis; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred C57BL; Psoriasis; Skin

2020
Role of keratinocytes and immune cells in the anti-inflammatory effects of Tripterygium wilfordii Hook. f. in a murine model of psoriasis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Volume: 77

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Proliferation; Cytokines; Dermatologic Agents; Disease Models, Animal; Drugs, Chinese Herbal; Imiquimod; Keratinocytes; Male; Mice, Inbred BALB C; Plant Roots; Psoriasis; T-Lymphocytes, Regulatory; Tripterygium

2020
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes.
    Toxicology and applied pharmacology, 2020, 10-15, Volume: 405

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Chaperonin 60; Disease Models, Animal; Down-Regulation; HaCaT Cells; HSP90 Heat-Shock Proteins; Humans; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Protein Binding; Pruritus; Psoriasis; Quinolizines

2020
Multi-component clobetasol-loaded monolithic lipid-polymer hybrid nanoparticles ameliorate imiquimod-induced psoriasis-like skin inflammation in Swiss albino mice.
    Acta biomaterialia, 2020, 10-01, Volume: 115

    Topics: Animals; Clobetasol; Imiquimod; Inflammation; Lipids; Mice; Nanoparticles; Polymers; Psoriasis

2020
An Autocrine Circuit of IL-33 in Keratinocytes Is Involved in the Progression of Psoriasis.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:3

    Topics: Adult; Animals; Autocrine Communication; Biopsy; Case-Control Studies; Disease Models, Animal; Disease Progression; Healthy Volunteers; Humans; Imiquimod; Injections, Intradermal; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Keratinocytes; Male; Mice; Middle Aged; Psoriasis; Recombinant Proteins; Severity of Illness Index; Signal Transduction; Skin; Transcriptional Activation; Up-Regulation

2021
Neutrophils Enhance Cutaneous Vascular Dilation and Permeability to Aggravate Psoriasis by Releasing Matrix Metallopeptidase 9.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:4

    Topics: Animals; Biopsy; Capillary Permeability; Cell Line; Chemotaxis; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Female; Imiquimod; Interleukin-23; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Neutrophil Infiltration; Neutrophils; Primary Cell Culture; Psoriasis; Recombinant Proteins; Skin; Transendothelial and Transepithelial Migration; Vasodilation

2021
A monocyte-keratinocyte-derived co-culture assay accurately identifies efficacies of BET inhibitors as therapeutic candidates for psoriasiform dermatitis.
    Journal of dermatological science, 2020, Volume: 100, Issue:1

    Topics: Acetanilides; Administration, Oral; Animals; Cell Line, Tumor; Coculture Techniques; Disease Models, Animal; Drug Evaluation, Preclinical; Epigenesis, Genetic; Female; HaCaT Cells; Heterocyclic Compounds, 3-Ring; Humans; Imiquimod; Inflammation Mediators; Mice; Monocytes; Psoriasis; Pyridones; Skin; Sulfonamides

2020
The Protective Effects of 18
    Journal of immunology research, 2020, Volume: 2020

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Glycyrrhetinic Acid; Imiquimod; Immunohistochemistry; Inflammation Mediators; Mice; Protective Agents; Psoriasis; Signal Transduction; STAT3 Transcription Factor; T-Lymphocyte Subsets; TOR Serine-Threonine Kinases

2020
Luteolin attenuates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 131

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Female; Imiquimod; Luteolin; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Psoriasis; RAW 264.7 Cells

2020
Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8
    Theranostics, 2020, Volume: 10, Issue:23

    Topics: Animals; Artemisinins; CD8-Positive T-Lymphocytes; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Imiquimod; Immunologic Memory; Interleukin-15; Interleukin-17; Male; Methotrexate; Mice; Psoriasis; Recurrence; Secondary Prevention; Skin; Skin Transplantation; Transplantation Chimera

2020
Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir
    Theranostics, 2020, Volume: 10, Issue:23

    Topics: Animals; Dendritic Cells; Disease Models, Animal; Female; Fibroblasts; Humans; Imiquimod; Macrophages; Membrane Proteins; Mice; Mice, Knockout; Psoriasis; RNA-Seq; Single-Cell Analysis; Skin; Transcription, Genetic; Transcriptome

2020
Thymol activates TRPM8-mediated Ca
    Toxicology and applied pharmacology, 2020, 11-15, Volume: 407

    Topics: Animals; Antipruritics; Behavior, Animal; Calcium; Cell Differentiation; Cytokines; Imiquimod; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurons; Pruritus; Psoriasis; Skin; Thymol; TRPM Cation Channels

2020
Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis.
    International journal of molecular sciences, 2020, Sep-30, Volume: 21, Issue:19

    Topics: Animals; Cell Lineage; Disease Models, Animal; Epidermis; Gene Expression Regulation; Granzymes; Humans; Imiquimod; Immunologic Memory; Integrin alpha1; Mice; Psoriasis; T-Lymphocytes

2020
IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis.
    International immunopharmacology, 2020, Volume: 89, Issue:Pt B

    Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Cells, Cultured; Disease Models, Animal; Gene Knock-In Techniques; Half-Life; Histocompatibility Antigens Class I; Imiquimod; Interleukin-17; Interleukin-23; Interleukin-23 Subunit p19; Leukocytes, Mononuclear; Macaca fascicularis; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phosphorylation; Psoriasis; Receptors, Fc; Signal Transduction; Skin; STAT3 Transcription Factor

2020
Evaluating the effect of rice (Oryza sativa L.: SRNC05053-6-2) crude extract on psoriasis using in vitro and in vivo models.
    Scientific reports, 2020, 10-19, Volume: 10, Issue:1

    Topics: Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Epidermis; Filaggrin Proteins; Humans; Imiquimod; Oryza; Plant Extracts; Psoriasis; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein A7; Skin; Skin, Artificial; Treatment Outcome

2020
Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice.
    Biological research, 2020, Oct-20, Volume: 53, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Cell Proliferation; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Rabbits; Umbelliferones

2020
Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis.
    Acta dermato-venereologica, 2020, Dec-09, Volume: 100, Issue:19

    Topics: Animals; Disease Models, Animal; Histamine; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2020
DGT, a novel heterocyclic diterpenoid, effectively suppresses psoriasis via inhibition of STAT3 phosphorylation.
    British journal of pharmacology, 2021, Volume: 178, Issue:3

    Topics: Animals; Disease Models, Animal; Diterpenes; Female; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Phosphorylation; Psoriasis; Skin

2021
4'-O-β-D-glucosyl-5-O-methylvisamminol ameliorates imiquimod-induced psoriasis-like dermatitis and inhibits inflammatory cytokines production by suppressing the NF-κB and MAPK signaling pathways.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2020, Volume: 53, Issue:12

    Topics: Animals; Chromones; Cytokines; Dermatitis; Glucosides; Imiquimod; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis

2020
A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes.
    International journal of molecular sciences, 2020, Nov-08, Volume: 21, Issue:21

    Topics: Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; Enzyme Inhibitors; Humans; Imiquimod; In Vitro Techniques; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Psoriasis; RNA, Messenger; Skin; Th17 Cells

2020
Curcuma's extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin, proliferating cell nuclear antigen and toll-like receptor expression.
    Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:3

    Topics: Animals; Curcuma; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Female; Guinea Pigs; Imiquimod; Keratins; Male; Mice; Mitosis; Plant Extracts; Proliferating Cell Nuclear Antigen; Propranolol; Psoriasis; Rhizome; Skin; Time Factors; Toll-Like Receptors; Vagina

2020
TLR2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation through Decrease in Regulatory T Cells and Impaired IL-10 Production.
    International journal of molecular sciences, 2020, Nov-13, Volume: 21, Issue:22

    Topics: Animals; Imiquimod; Inflammation; Interleukin-10; Mice; Mice, Knockout; Psoriasis; Skin; T-Lymphocytes, Regulatory; Toll-Like Receptor 2

2020
Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice.
    Scientific reports, 2020, 11-19, Volume: 10, Issue:1

    Topics: Administration, Topical; Animals; Cells, Cultured; Chemokines; Cytokines; Disease Models, Animal; Extracellular Traps; Imiquimod; Interleukin-1; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Mice, Mutant Strains; Neutrophils; Ornithine; Psoriasis

2020
Small interfering RNA targeting of keratin 17 reduces inflammation in imiquimod-induced psoriasis-like dermatitis.
    Chinese medical journal, 2020, Nov-20, Volume: 133, Issue:24

    Topics: Animals; Dermatitis; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Keratin-17; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Small Interfering; Skin

2020
IL-37 Expression Is Downregulated in Lesional Psoriasis Skin.
    ImmunoHorizons, 2020, 11-25, Volume: 4, Issue:11

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Female; Humans; Imiquimod; Inflammation; Interleukin-1; Interleukin-17; Keratinocytes; Mice; Mice, Inbred C57BL; Psoriasis; Tumor Necrosis Factor-alpha

2020
Depressive-like behaviors in mice with Imiquimod-induced psoriasis.
    International immunopharmacology, 2020, Volume: 89, Issue:Pt B

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Cytokines; Depression; Disease Models, Animal; Epinephrine; Exploratory Behavior; Fluoxetine; Food Preferences; gamma-Aminobutyric Acid; Imiquimod; Male; Mice, Inbred BALB C; Neurotransmitter Agents; Norepinephrine; Open Field Test; Psoriasis; Serotonin; Skin

2020
Chemical profiling and anti-psoriatic activity of marine sponge (Dysidea avara) in induced imiquimod-psoriasis-skin model.
    PloS one, 2020, Volume: 15, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Biological Products; Disease Models, Animal; Drug Evaluation, Preclinical; Dysidea; Female; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Mice; Psoriasis; Severity of Illness Index; Skin; Tumor Necrosis Factor-alpha

2020
OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:6

    Topics: Animals; Cell Differentiation; Cell Proliferation; Disease Models, Animal; DNA-Binding Proteins; Epidermis; Female; Humans; Hyperplasia; Imiquimod; Interleukin-1alpha; Male; Mice, Knockout; Psoriasis; RNA-Seq; Signal Transduction; Single-Cell Analysis; Transcription Factors; Up-Regulation

2021
ALK3 Is Not Required for the Embryonic Development, Homeostasis, and Repopulation of Epidermal Langerhans Cells in Steady and Inflammatory States.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:7

    Topics: Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Disease Models, Animal; Embryo, Mammalian; Embryonic Development; Homeostasis; Humans; Imiquimod; Langerhans Cells; Mice; Mice, Knockout; Psoriasis; Severity of Illness Index; Signal Transduction

2021
Deletion of
    Journal of immunology (Baltimore, Md. : 1950), 2021, 02-01, Volume: 206, Issue:3

    Topics: Animals; Antibodies, Blocking; Calgranulin A; Calgranulin B; Cells, Cultured; Disease Models, Animal; Humans; Hyperplasia; Imiquimod; Interleukin-17; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Th17 Cells

2021
Protocol for Flow Cytometric Detection of Immune Cell Infiltration in the Epidermis and Dermis of a Psoriasis Mouse Model.
    STAR protocols, 2020, 12-18, Volume: 1, Issue:3

    Topics: Aminoquinolines; Animals; Cytokines; Dermis; Disease Models, Animal; Epidermal Cells; Epidermis; Flow Cytometry; Imiquimod; Inflammation; Leukemic Infiltration; Mice; Psoriasis; Skin

2020
Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation.
    International journal of molecular sciences, 2021, Jan-13, Volume: 22, Issue:2

    Topics: Administration, Topical; Animals; Biomarkers; Biopsy; Disease Models, Animal; Exosomes; Imiquimod; Mesenchymal Stem Cells; Mice; Permeability; Phenotype; Psoriasis; Skin; Skin Absorption

2021
Topical Application of BMS-509744, a Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase, Ameliorates Imiquimod-Induced Skin Inflammation in Mice.
    Biological & pharmaceutical bulletin, 2021, Apr-01, Volume: 44, Issue:4

    Topics: Animals; CD3 Complex; Dermatitis; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Protein-Tyrosine Kinases; Psoriasis; Skin; Th17 Cells; Tumor Necrosis Factor-alpha

2021
Short-Term Western Diet Intake Promotes IL-23‒Mediated Skin and Joint Inflammation Accompanied by Changes to the Gut Microbiota in Mice.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:7

    Topics: Animals; Arthritis, Psoriatic; Diet, Western; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Humans; Imiquimod; Interleukin-23; Mice; Psoriasis; Signal Transduction

2021
Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Acyltransferases; Animals; Cell Line; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Interferon-alpha; Lymphocyte Activation; Male; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Signal Transduction; Skin; T-Lymphocytes; Tumor Suppressor Proteins; Up-Regulation

2020
Application of imiquimod-induced murine psoriasis model in evaluating interleukin-17A antagonist.
    BMC immunology, 2021, 01-28, Volume: 22, Issue:1

    Topics: Animals; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Imiquimod; Interleukin-17; Mice; Mice, Inbred C57BL; Psoriasis; Signal Transduction

2021
Pentacyclic triterpene compounds from loquat leaves reduce skin inflammation and epidermal hyperplasia in psoriasis via inhibiting the Th17 cells.
    Molecular immunology, 2021, Volume: 132

    Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Disease Models, Animal; Epidermis; Eriobotrya; Humans; Hyperplasia; Imiquimod; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Pentacyclic Triterpenes; Plant Leaves; Psoriasis; Th17 Cells

2021
Strain specific response of mice to IMQ-induced psoriasis.
    Journal of basic and clinical physiology and pharmacology, 2021, Feb-08, Volume: 32, Issue:5

    Topics: Animals; Imiquimod; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Psoriasis

2021
Skin-Homing Regulatory B Cells Required for Suppression of Cutaneous Inflammation.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:8

    Topics: Animals; B-Lymphocytes, Regulatory; Cell Movement; Dermatitis; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-10; Male; Mice; Psoriasis; Skin

2021
Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice.
    Journal of ethnopharmacology, 2021, May-23, Volume: 272

    Topics: Abietanes; Animals; Anti-Inflammatory Agents; Correlation of Data; Cytokines; Gastrointestinal Microbiome; Imiquimod; Inflammation; Male; Medicine, Chinese Traditional; Mice, Inbred BALB C; Psoriasis; RNA, Ribosomal, 16S; T-Lymphocytes, Regulatory; Th17 Cells

2021
JNK1 Signaling Downstream of the EGFR Pathway Contributes to Aldara
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Cytokines; Disease Models, Animal; Epigenome; ErbB Receptors; Female; Imiquimod; Inflammation Mediators; Keratinocytes; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Myeloid Cells; Psoriasis; Signal Transduction; Skin; Transcriptome

2020
Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation.
    Experimental biology and medicine (Maywood, N.J.), 2021, Volume: 246, Issue:11

    Topics: Animals; Antigens, CD1; Cell Line; Disease Models, Animal; Gene Expression Regulation; Group IV Phospholipases A2; Humans; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Male; Mice, Inbred BALB C; Psoriasis; RNA, Small Interfering

2021
The Skin-Liver Axis Modulates the Psoriasiform Phenotype and Involves Leucine-Rich α-2 Glycoprotein.
    Journal of immunology (Baltimore, Md. : 1950), 2021, 04-01, Volume: 206, Issue:7

    Topics: Animals; Biomarkers; Cytokines; Disease Models, Animal; Glycoproteins; Humans; Imiquimod; Inflammation Mediators; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Up-Regulation

2021
CCR4 Involvement in the Expansion of T Helper Type 17 Cells in a Mouse Model of Psoriasis.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:8

    Topics: Animals; Cell Communication; Cell Proliferation; Cells, Cultured; Coculture Techniques; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Transgenic; Primary Cell Culture; Psoriasis; Receptors, CCR4; Skin; Th17 Cells

2021
The nerve injuries attenuate the persistence of psoriatic lesions.
    Journal of dermatological science, 2021, Volume: 102, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Animals; Denervation; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Imiquimod; Male; Mice; Middle Aged; Neuroimmunomodulation; Peripheral Nerve Injuries; Psoriasis; Retrospective Studies; Skin

2021
MTH1 Inhibitors for the Treatment of Psoriasis.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:8

    Topics: Administration, Cutaneous; Animals; Apoptosis; Biopsy; Cell Line, Tumor; Disease Models, Animal; DNA Repair Enzymes; Female; Humans; Imiquimod; Keratinocytes; Mice; Oxidative Stress; Phosphoric Monoester Hydrolases; Primary Cell Culture; Psoriasis; Skin

2021
Qinzhuliangxue mixture alleviates psoriasis-like skin lesions via inhibiting the IL6/STAT3 axis.
    Journal of ethnopharmacology, 2021, Jun-28, Volume: 274

    Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Cytokines; Drugs, Chinese Herbal; Hypoxia-Inducible Factor 1, alpha Subunit; Imiquimod; Keratinocytes; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Phytochemicals; Protein Interaction Maps; Psoriasis; Skin; STAT3 Transcription Factor

2021
miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation.
    International immunopharmacology, 2021, Volume: 96

    Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Humans; Imiquimod; Janus Kinase 3; Keratinocytes; Lipocalin-2; Male; MicroRNAs; Psoriasis; Rats; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor

2021
Selenium nanoparticles produce a beneficial effect in psoriasis by reducing epidermal hyperproliferation and inflammation.
    Journal of nanobiotechnology, 2021, Apr-13, Volume: 19, Issue:1

    Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line; Glycogen Synthase Kinase 3 beta; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Inbred BALB C; Nanoparticles; Oxidation-Reduction; Phosphorylation; Psoriasis; Reactive Oxygen Species; Selenium; STAT3 Transcription Factor

2021
Green Phellodendri Chinensis Cortex-based carbon dots for ameliorating imiquimod-induced psoriasis-like inflammation in mice.
    Journal of nanobiotechnology, 2021, Apr-15, Volume: 19, Issue:1

    Topics: Animals; Carbon; Cytokines; Disease Models, Animal; Imiquimod; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Psoriasis; RAW 264.7 Cells; Skin

2021
Fingolimod ameliorates imiquimod-induced psoriasiform dermatitis by sequestrating interleukin-17-producing ?d T cells in secondary lymph nodes.
    Journal of dermatological science, 2021, Volume: 102, Issue:2

    Topics: Animals; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Female; Fingolimod Hydrochloride; Humans; Imiquimod; Interleukin-17; Intraepithelial Lymphocytes; Langerhans Cells; Lymph Nodes; Mice; Psoriasis; Skin; Up-Regulation

2021
Improved imiquimod-induced psoriasis like dermatitis using microneedles in mice.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2021, Volume: 164

    Topics: Administration, Cutaneous; Animals; Cytokines; Dermatitis; Disease Models, Animal; Drug Delivery Systems; Female; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Needles; Pharmaceutical Preparations; Polyesters; Polymers; Psoriasis; Skin; Swine

2021
Discovery of a novel RORγ antagonist with skin-restricted exposure for topical treatment of mild to moderate psoriasis.
    Scientific reports, 2021, 04-28, Volume: 11, Issue:1

    Topics: Administration, Topical; Animals; Benzimidazoles; Binding Sites; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Stability; Humans; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Skin

2021
Rapamycin Alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Aggravated Dermatitis in Mice with Imiquimod-Induced Psoriasis-Like Dermatitis by Inducing Autophagy.
    International journal of molecular sciences, 2021, Apr-12, Volume: 22, Issue:8

    Topics: Animals; Autophagy; Cell Differentiation; Cells, Cultured; Cytochrome P-450 CYP1A1; Dermatitis; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; NADPH Oxidase 4; NF-E2-Related Factor 2; Polychlorinated Dibenzodioxins; Psoriasis; Receptors, Aryl Hydrocarbon; Sirolimus

2021
Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo.
    Biochemical pharmacology, 2021, Volume: 190

    Topics: Adult; Animals; Cell Line; Cells, Cultured; Female; HEK293 Cells; Humans; Imiquimod; Inflammation; Male; Mice; Mice, Inbred BALB C; Neutrophils; Psoriasis; Receptors, Formyl Peptide; Triterpenes; Ursolic Acid; Young Adult

2021
2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice.
    Experimental & molecular medicine, 2021, Volume: 53, Issue:5

    Topics: Animals; Biomarkers; Cell Survival; Cinnamates; Cytokines; Disease Management; Disease Models, Animal; Disease Susceptibility; Imiquimod; Mice; Psoriasis; Pyruvate Kinase; Signal Transduction; STAT3 Transcription Factor; T-Lymphocyte Subsets; Th17 Cells

2021
A Targetable, Noncanonical Signal Transducer and Activator of Transcription 3 Activation Induced by the Y-Less Region of IL-22 Receptor Orchestrates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:11

    Topics: Animals; Citrobacter rodentium; Enterobacteriaceae Infections; Imiquimod; Interleukin-22; Interleukins; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, Interleukin; STAT3 Transcription Factor

2021
Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Case-Control Studies; CD3 Complex; Chemotaxis, Leukocyte; Desmogleins; Disease Models, Animal; Down-Regulation; Female; Humans; Imiquimod; Inflammation Mediators; Psoriasis; Rats, Sprague-Dawley; Rats, Transgenic; Skin; T-Lymphocytes

2021
Rosmarinic acid protects mice from imiquimod induced psoriasis-like skin lesions by inhibiting the IL-23/Th17 axis via regulating Jak2/Stat3 signaling pathway.
    Phytotherapy research : PTR, 2021, Volume: 35, Issue:8

    Topics: Animals; Cinnamates; Cytokines; Depsides; Disease Models, Animal; HaCaT Cells; Humans; Imiquimod; Interleukin-23; Janus Kinase 2; Mice; Mice, Inbred BALB C; Psoriasis; Rosmarinic Acid; Signal Transduction; Skin; STAT3 Transcription Factor; Th17 Cells

2021
Supplemental Leuconostoc mesenteroides strain NTM048 attenuates imiquimod-induced psoriasis in mice.
    Journal of applied microbiology, 2021, Volume: 131, Issue:6

    Topics: Animals; Disease Models, Animal; Imiquimod; Leuconostoc mesenteroides; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2021
Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.
    BMC immunology, 2021, 05-27, Volume: 22, Issue:1

    Topics: Adult; Animals; Anti-Inflammatory Agents; Carbazoles; Disease Models, Animal; Female; Glycyrrhiza; Glycyrrhizic Acid; HaCaT Cells; Humans; Imiquimod; Interleukin-17; Mice; Psoriasis; RNA, Small Interfering; Sirtuin 1; Skin; STAT3 Transcription Factor

2021
Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice.
    Scientific reports, 2021, 05-28, Volume: 11, Issue:1

    Topics: Animals; Dermatitis; Disease Models, Animal; Female; Gastrointestinal Microbiome; Imiquimod; Lactic Acid; Mice; Mice, Inbred C57BL; Microbiota; Psoriasis; Skin; Staphylococcus; Succinic Acid

2021
Molecular and histopathological profiling of imiquimod induced dermatosis in Swiss Wistar rats: contribution to the rat model for novel anti-psoriasis treatments.
    Molecular biology reports, 2021, Volume: 48, Issue:5

    Topics: Administration, Cutaneous; Animals; Betamethasone; Cytokines; Disease Models, Animal; Down-Regulation; Imiquimod; Male; Ointments; Psoriasis; Rats; Rats, Wistar; Severity of Illness Index; Signal Transduction; Skin; Transcriptome; Treatment Outcome; Up-Regulation

2021
Xenobiotic Receptor CAR Is Highly Induced in Psoriasis and Promotes Keratinocyte Proliferation.
    The Journal of investigative dermatology, 2021, Volume: 141, Issue:12

    Topics: Animals; Cell Cycle; Cell Proliferation; Constitutive Androstane Receptor; Cytokines; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Ki-67 Antigen; Mice; Psoriasis

2021
Tacrolimus-loaded chitosan nanoparticles for enhanced skin deposition and management of plaque psoriasis.
    Carbohydrate polymers, 2021, Sep-15, Volume: 268

    Topics: Administration, Cutaneous; Animals; Chitosan; Drug Carriers; Drug Liberation; Ear; Imiquimod; Immunosuppressive Agents; Mice, Inbred C57BL; Nanoparticles; Particle Size; Psoriasis; Rats, Sprague-Dawley; Skin; Tacrolimus

2021
Protectin D1 reduces imiquimod-induced psoriasiform skin inflammation.
    International immunopharmacology, 2021, Volume: 98

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Docosahexaenoic Acids; Female; HaCaT Cells; Humans; Imiquimod; Injections, Subcutaneous; Keratinocytes; Mice; Phosphorylation; Psoriasis; Signal Transduction; Skin; Spleen; STAT1 Transcription Factor; Th1 Cells; Th17 Cells

2021
Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways.
    International immunopharmacology, 2021, Volume: 96

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Cytokines; Dermatitis; Disease Models, Animal; Down-Regulation; Flavonoids; Heme Oxygenase-1; Imiquimod; Male; Membrane Proteins; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Peroxidase; Psoriasis; Signal Transduction; Spleen

2021
Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy.
    International journal of pharmaceutics, 2021, Aug-10, Volume: 605

    Topics: Administration, Topical; Animals; Imiquimod; Methotrexate; Mice; Mice, Inbred BALB C; Niacinamide; Psoriasis; Skin

2021
Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis.
    Scientific reports, 2021, 06-25, Volume: 11, Issue:1

    Topics: Animals; Cell Line; Cell Proliferation; Disease Models, Animal; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Matrix Metalloproteinase 13; Mice; Nicotinic Acids; Psoriasis; Retinoids; Ultraviolet Rays; Ultraviolet Therapy

2021
Impact of barrier tissue inflammation and physical activity on joint homeostasis in mice.
    Rheumatology (Oxford, England), 2022, 04-11, Volume: 61, Issue:4

    Topics: Animals; Disease Models, Animal; Homeostasis; Humans; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Psoriasis

2022
The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
    Nature communications, 2021, 07-02, Volume: 12, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Chemokine CCL2; Cytokines; Dendritic Cells; Dermatitis; Endoribonucleases; Epigenomics; Humans; Imiquimod; Inflammation; Interleukin-6; Macrophages; Mice; Mice, Knockout; Myeloid Cells; Psoriasis; Ribonucleases; Skin; Tumor Necrosis Factor-alpha

2021
Taxifolin inhibits keratinocyte proliferation and ameliorates imiquimod-induced psoriasis-like mouse model via regulating cytoplasmic phospholipase A2 and PPAR-γ pathway.
    International immunopharmacology, 2021, Volume: 99

    Topics: Animals; Cell Line; Cell Proliferation; Cytoplasm; Disease Models, Animal; Down-Regulation; Humans; Imiquimod; Keratinocytes; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phospholipases A2; Phosphorylation; PPAR gamma; Proteomics; Psoriasis; Quercetin; Signal Transduction

2021
Tuhuaiyin alleviates imiquimod-induced psoriasis via inhibiting the properties of IL-17-producing cells and remodels the gut microbiota.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 141

    Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Humans; Imiquimod; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Network Pharmacology; Psoriasis

2021
Transient Induction of Fever in the Imiquimod C57BL/6 Mouse Model of Psoriasis-Like Disease Involves IL-1 and IL-6 but Not IL-36.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:1

    Topics: Animals; Disease Models, Animal; Fever; Humans; Imiquimod; Interleukin-1; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin

2022
Inhibition of CtBP-Regulated Proinflammatory Gene Transcription Attenuates Psoriatic Skin Inflammation.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:2

    Topics: Alcohol Oxidoreductases; Animals; Anti-Inflammatory Agents; Cell Proliferation; Disease Models, Animal; DNA-Binding Proteins; HaCaT Cells; Humans; Imiquimod; Keratinocytes; Mice; Mice, Transgenic; Psoriasis; Transcriptional Activation

2022
Differential Involvement of Programmed Cell Death Ligands in Skin Immune Responses.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:1

    Topics: Animals; Antigen Presentation; B7-H1 Antigen; Calcitriol; Cells, Cultured; Cytokines; Dendritic Cells; Dermatitis, Atopic; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; Humans; Imiquimod; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Ligand 2 Protein; Psoriasis; Skin; Th1 Cells; Th17 Cells; Th2 Cells

2022
Capsaicin attenuates imiquimod-induced epidermal hyperplasia and cutaneous inflammation in a murine model of psoriasis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 141

    Topics: Administration, Topical; Animals; Antineoplastic Agents; Antipruritics; Capsaicin; Dermatitis; Disease Models, Animal; Epidermis; Female; Hyperplasia; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2021
Modular pharmacology-based approach to identify hub genes and kernel pathways of taodan granules treated psoriasis.
    Journal of ethnopharmacology, 2021, Nov-15, Volume: 280

    Topics: Algorithms; Animals; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; HaCaT Cells; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Network Pharmacology; Psoriasis; RNA, Messenger; Signal Transduction; Up-Regulation

2021
IFN-κ Is a Rheostat for Development of Psoriasiform Inflammation.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:1

    Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Interferon Type I; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Up-Regulation

2022
Curcumin alleviates imiquimod-induced psoriasis in progranulin-knockout mice.
    European journal of pharmacology, 2021, Oct-15, Volume: 909

    Topics: Animals; Cell Proliferation; Curcumin; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Keratinocytes; Male; Mice; Mice, Knockout; Progranulins; Psoriasis

2021
TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2021, 10-10, Volume: 338

    Topics: Animals; Imiquimod; Mice; Nanoparticles; Psoriasis; RNA, Small Interfering; Tumor Necrosis Factor-alpha

2021
Glycerol Improves Skin Lesion Development in the Imiquimod Mouse Model of Psoriasis: Experimental Confirmation of Anecdotal Reports from Patients with Psoriasis.
    International journal of molecular sciences, 2021, Aug-15, Volume: 22, Issue:16

    Topics: Animals; Aquaporin 3; Disease Models, Animal; Glycerol; Humans; Imiquimod; Mice; Mice, Knockout; Phospholipase D; Psoriasis; Skin

2021
Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice by inhibiting the maturation and activation of dendritic cells.
    International journal of molecular medicine, 2017, Volume: 39, Issue:5

    Topics: Acetophenones; Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Cytokines; Dendritic Cells; Disease Models, Animal; Imiquimod; Inflammation Mediators; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Myeloid Differentiation Factor 88; Psoriasis; Skin; Toll-Like Receptor 8

2017
Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation.
    Journal of immunology (Baltimore, Md. : 1950), 2017, 05-01, Volume: 198, Issue:9

    Topics: Adult; Aged; Aminoquinolines; Animals; Antibodies, Blocking; Cells, Cultured; Female; Gene Knockout Techniques; Humans; Imiquimod; Inflammation; Interleukin-22; Interleukins; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Middle Aged; Psoriasis; Rats; Rats, Sprague-Dawley; Receptors, Interleukin; Signal Transduction; Skin; Young Adult

2017
CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells.
    Journal of immunology (Baltimore, Md. : 1950), 2017, 05-15, Volume: 198, Issue:10

    Topics: Aminoquinolines; Animals; Chemokine CCL4; Chemokine CCL5; Chemokines; Chemokines, CXC; Chemotaxis; Cytokines; Dermatitis; Epidermis; Humans; Imiquimod; Keratinocytes; Mice; Myeloid-Derived Suppressor Cells; Psoriasis; Skin; T-Lymphocytes, Regulatory

2017
PAMs ameliorates the imiquimod-induced psoriasis-like skin disease in mice by inhibition of translocation of NF-κB and production of inflammatory cytokines.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Active Transport, Cell Nucleus; Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Female; Humans; Imiquimod; Interferon-gamma; Mice, Inbred BALB C; NF-kappa B; Phytotherapy; Psoriasis; Skin

2017
Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway.
    International immunopharmacology, 2017, Volume: 48

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Catalase; Cytokines; Glutathione; Imiquimod; Male; Malondialdehyde; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Quercetin; Signal Transduction; Skin; Superoxide Dismutase

2017
Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice.
    Acta dermato-venereologica, 2017, Aug-31, Volume: 97, Issue:8

    Topics: Aminoquinolines; Animals; Behavior, Animal; Disease Models, Animal; Drug Eruptions; Imiquimod; Male; Mice, Inbred C57BL; Narcotic Antagonists; Psoriasis; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Skin; Spinal Cord

2017
IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression.
    Cytokine, 2017, Volume: 97

    Topics: Aminoquinolines; Animals; Brain; Depression; Depressive Disorder, Major; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-17; MAP Kinase Signaling System; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Psoriasis

2017
Imiquimod induced ApoE-deficient mice might be a composite animal model for the study of psoriasis and dyslipideamia comorbidity.
    Journal of dermatological science, 2017, Volume: 88, Issue:1

    Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aminoquinolines; Animals; Back; Cell Proliferation; Cholesterol; Comorbidity; Disease Models, Animal; Dyslipidemias; Imiquimod; Interleukin-17; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Psoriasis; Signal Transduction; Skin; STAT3 Transcription Factor

2017
Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice.
    Acta dermato-venereologica, 2017, Oct-02, Volume: 97, Issue:9

    Topics: Administration, Topical; Aminoquinolines; Animals; Caspase 14; Dendritic Cells; Disease Models, Animal; Imiquimod; Immunosuppressive Agents; Keratin-10; Keratin-14; Ki-67 Antigen; Langerhans Cells; Lymph Nodes; Macrophages; Membrane Proteins; Mice, Inbred BALB C; Neovascularization, Physiologic; Protein Precursors; Psoriasis; Sirolimus; Skin; TOR Serine-Threonine Kinases

2017
The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice.
    Purinergic signalling, 2017, Volume: 13, Issue:4

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cell Line; Female; Humans; Imiquimod; Inflammation; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Purinergic P2X7

2017
Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation.
    Stem cells (Dayton, Ohio), 2017, Volume: 35, Issue:8

    Topics: Aminoquinolines; Animals; Asymmetric Cell Division; Carcinoma, Squamous Cell; Cell Proliferation; Homeostasis; Humans; Imiquimod; Interleukin-17; Mice; Psoriasis

2017
Cyr61/CCN1 induces CCL20 production by keratinocyte via activating p38 and JNK/AP-1 pathway in psoriasis.
    Journal of dermatological science, 2017, Volume: 88, Issue:1

    Topics: Aminoquinolines; Animals; Biopsy; Chemokine CCL20; Cysteine-Rich Protein 61; Disease Models, Animal; Epidermis; Female; Gene Knockdown Techniques; Humans; Imiquimod; Interleukin-23; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Lymphocyte Activation; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Promoter Regions, Genetic; Psoriasis; RNA Interference; RNA, Small Interfering; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Up-Regulation

2017
Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.
    Journal of leukocyte biology, 2017, Volume: 102, Issue:3

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Immunity, Innate; Interleukin-1beta; Interleukin-23; Mice; Mice, Knockout; Myeloid Cells; Myeloid Differentiation Factor 88; Psoriasis; Skin

2017
Drug Repurposing by Simulating Flow Through Protein-Protein Interaction Networks.
    Clinical pharmacology and therapeutics, 2018, Volume: 103, Issue:3

    Topics: Algorithms; Animals; Cell Line; Computer Simulation; Dermatitis; Drug Evaluation, Preclinical; Drug Repositioning; Ear, External; Gene Regulatory Networks; Humans; Imiquimod; Machine Learning; Mice; Mice, Inbred BALB C; NF-kappa B; Protein Interaction Domains and Motifs; Protein Interaction Maps; Psoriasis; RNA; Support Vector Machine; Tumor Necrosis Factor-alpha

2018
Rhododendrin inhibits toll-like receptor-7-mediated psoriasis-like skin inflammation in mice.
    Experimental & molecular medicine, 2017, 06-30, Volume: 49, Issue:6

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Glycosides; Humans; Imiquimod; Keratinocytes; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NF-kappa B; Phenols; Primary Cell Culture; Psoriasis; Rhododendron; RNA, Messenger; Skin; Toll-Like Receptor 7

2017
Imiquimod-applied Interleukin-10 deficient mice better reflects severe and persistent psoriasis with systemic inflammatory state.
    Experimental dermatology, 2018, Volume: 27, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Body Weight; Cytokines; Dermatitis; Disease Models, Animal; Epidermis; Imiquimod; Inflammation; Interleukin-10; Interleukin-17; Keratinocytes; Leukocyte Common Antigens; Male; Mice; Mice, Inbred C57BL; Organ Size; Psoriasis; RNA, Messenger; Skin; Spleen; Time Factors

2018
Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Adult; Aged; Aminoquinolines; Animals; Cells, Cultured; Chemokine CCL20; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-17; Keratinocytes; Liver; Male; Mice; Mice, Inbred C57BL; Middle Aged; Psoriasis; Receptors, CCR6; Recombinant Proteins; Serum Amyloid A Protein; Skin; Th17 Cells; Up-Regulation

2017
Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin.
    European journal of pharmacology, 2017, Oct-15, Volume: 813

    Topics: Aminoquinolines; Biomarkers; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Curcumin; Cytokines; Drug Evaluation, Preclinical; Filaggrin Proteins; Humans; Imiquimod; Keratinocytes; Molecular Docking Simulation; Protein Conformation; Psoriasis; Skin

2017
GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency.
    PloS one, 2017, Volume: 12, Issue:8

    Topics: Aminoquinolines; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imiquimod; Interferon Inducers; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis

2017
Role of neurturin in spontaneous itch and increased nonpeptidergic intraepidermal fiber density in a mouse model of psoriasis.
    Pain, 2017, Volume: 158, Issue:11

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antibodies; Calcitonin Gene-Related Peptide; Disease Models, Animal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Imiquimod; Male; Mice; Mice, Inbred C57BL; Nerve Fibers; Neurturin; Pruritus; Psoriasis; Receptors, Purinergic P2X3; RNA, Messenger; Skin

2017
Lack of Galanin Receptor 3 Alleviates Psoriasis by Altering Vascularization, Immune Cell Infiltration, and Cytokine Expression.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:1

    Topics: Adult; Animals; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Neovascularization, Pathologic; Nestin; Neutrophil Infiltration; Neutrophils; Psoriasis; Receptor, Galanin, Type 2; Receptor, Galanin, Type 3; Severity of Illness Index; Skin

2018
IL-1β and IL-23 Promote Extrathymic Commitment of CD27
    Journal of immunology (Baltimore, Md. : 1950), 2017, 10-15, Volume: 199, Issue:8

    Topics: Aminoquinolines; Animals; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Interleukin-1beta; Interleukin-2 Receptor beta Subunit; Interleukin-23; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Interleukin; T-Lymphocytes; Tumor Necrosis Factor Receptor Superfamily, Member 7

2017
Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue.
    The Journal of allergy and clinical immunology, 2018, Volume: 141, Issue:3

    Topics: Animals; Calcitriol; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Interleukin-12 Subunit p40; Interleukin-17; Interleukin-23 Subunit p19; Mice; Psoriasis; Th17 Cells

2018
Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice.
    Journal of food and drug analysis, 2017, Volume: 25, Issue:3

    Topics: Aminoquinolines; Animals; Imiquimod; Interleukin-17; Lactobacillus pentosus; Mice; Psoriasis

2017
Effect of Topical Application of Black Seed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino Rats.
    Anatomical record (Hoboken, N.J. : 2007), 2018, Volume: 301, Issue:1

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Chemotherapy, Adjuvant; Dermis; Disease Models, Animal; Epidermis; Fibrillar Collagens; Humans; Imiquimod; Male; Nigella sativa; Plant Oils; Psoriasis; Rats; Seeds; Treatment Outcome

2018
CD100-Plexin-B2 Promotes the Inflammation in Psoriasis by Activating NF-κB and the Inflammasome in Keratinocytes.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:2

    Topics: Animals; Antigens, CD; Biopsy; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Gene Expression Regulation; Healthy Volunteers; Humans; Imiquimod; Inflammasomes; Keratinocytes; Mice, Inbred BALB C; Nerve Tissue Proteins; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Primary Cell Culture; Protein Binding; Psoriasis; RNA, Small Interfering; Semaphorins; Signal Transduction; Skin

2018
Toll-like receptor 7/8 agonists stimulate plasmacytoid dendritic cells to initiate T
    The Journal of allergy and clinical immunology, 2018, Volume: 141, Issue:4

    Topics: Administration, Cutaneous; Adult; Aged; Biomarkers; Case-Control Studies; Dendritic Cells; Dermatitis, Contact; Female; Flow Cytometry; Humans; Imiquimod; Immunohistochemistry; Male; Middle Aged; Models, Biological; Psoriasis; Real-Time Polymerase Chain Reaction; Th17 Cells; Toll-Like Receptor 7; Toll-Like Receptor 8

2018
How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:2

    Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Imiquimod; Immunosuppressive Agents; Male; Mice; Mice, Hairless; Mice, Inbred BALB C; Psoriasis; Skin; Tacrolimus; Treatment Outcome

2018
IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice.
    Scientific reports, 2017, 09-29, Volume: 7, Issue:1

    Topics: Animals; Cell Differentiation; CX3C Chemokine Receptor 1; Dermatitis, Atopic; Disease Models, Animal; Gene Expression Regulation; Imiquimod; Interleukin-17; Lectins, C-Type; Lipopolysaccharides; Macrophage Activation; Macrophages; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Transgenic; Nitric Oxide Synthase Type II; Phosphoproteins; Psoriasis; Receptors, Cell Surface; Signal Transduction; Skin; STAT1 Transcription Factor; STAT3 Transcription Factor

2017
Thalidomide Improves Psoriasis-like Lesions and Inhibits Cutaneous VEGF Expression without Alteration of Microvessel Density in Imiquimod- induced Psoriatic Mouse Model.
    Current vascular pharmacology, 2018, Volume: 16, Issue:5

    Topics: Acitretin; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Female; Imiquimod; Mice, Inbred BALB C; Microvessels; Neovascularization, Pathologic; Psoriasis; Signal Transduction; Skin; Thalidomide; Vascular Endothelial Growth Factor A

2018
Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model.
    International journal of biological macromolecules, 2018, Apr-15, Volume: 110

    Topics: Aminoquinolines; Animals; Chitin; Disease Models, Animal; Drug Delivery Systems; Humans; Imiquimod; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis; THP-1 Cells

2018
Oral Administration of Vanillin Improves Imiquimod-Induced Psoriatic Skin Inflammation in Mice.
    Journal of agricultural and food chemistry, 2017, Nov-29, Volume: 65, Issue:47

    Topics: Aminoquinolines; Animals; Benzaldehydes; Female; Humans; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2017
High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.
    Scientific reports, 2017, 10-26, Volume: 7, Issue:1

    Topics: Animals; Chemokine CCL20; Dermatitis; Diet, High-Fat; Disease Models, Animal; Endothelial Cells; Imiquimod; Interleukin-17; Keratinocytes; Male; Mice, Inbred C57BL; Mice, Obese; Obesity; Psoriasis; Skin; T-Lymphocytes

2017
Anti-Psoriasis Effects and Mechanisms of Α-(8-Quinolinoxy) Zinc Phthalocyanine-Mediated Photodynamic Therapy.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 44, Issue:1

    Topics: Aminoquinolines; Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Epidermis; Epithelial Cells; Female; Guinea Pigs; Humans; Imiquimod; Indoles; Interleukin-17; Isoindoles; Lasers; Male; Mice; Mice, Inbred ICR; Mice, Nude; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Propranolol; Psoriasis; Zinc Compounds

2017
Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-κB pathways.
    Journal of dermatological science, 2018, Volume: 89, Issue:2

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Dermatitis; Disease Models, Animal; Docosahexaenoic Acids; Drug Evaluation, Preclinical; Humans; Imiquimod; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Psoriasis; Severity of Illness Index; Signal Transduction; Skin; Skin Cream

2018
Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.
    Scientific reports, 2017, Nov-14, Volume: 7, Issue:1

    Topics: Animals; B7-H1 Antigen; Bone Marrow Cells; CD4-Positive T-Lymphocytes; Cell Differentiation; Dendritic Cells; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Lymph Nodes; Mice; Plasma Gases; Psoriasis; Th17 Cells

2017
Essential Role of CARD14 in Murine Experimental Psoriasis.
    Journal of immunology (Baltimore, Md. : 1950), 2018, 01-01, Volume: 200, Issue:1

    Topics: Aminoquinolines; Animals; CARD Signaling Adaptor Proteins; Chimera; Guanylate Kinases; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Langerhans Cells; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Molecular Targeted Therapy; Psoriasis; Skin; T-Lymphocytes; Toll-Like Receptor 7; Toll-Like Receptor 9; Transcriptome

2018
Liver fibrosis is associated with cutaneous inflammation in the imiquimod-induced murine model of psoriasiform dermatitis.
    The British journal of dermatology, 2018, Volume: 179, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Eruptions; Imiquimod; Interferon Inducers; Liver Cirrhosis; Male; Mice, Inbred C57BL; Psoriasis

2018
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17.
    Pharmacological research, 2018, Volume: 129

    Topics: Adenine; Adenosylhomocysteinase; Administration, Topical; Animals; Anti-Inflammatory Agents; Butyrates; Cells, Cultured; Cytokines; Female; Humans; Imiquimod; Keratinocytes; Mice, Inbred BALB C; Psoriasis; T-Lymphocytes

2018
Decrease of galectin-3 in keratinocytes: A potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis.
    Journal of autoimmunity, 2018, Volume: 89

    Topics: Animals; Biomarkers; Cells, Cultured; Disease Models, Animal; Disease Progression; Galectin 3; Humans; Imiquimod; Inflammation; Keratinocytes; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Phenylurea Compounds; Psoriasis; Receptors, Interleukin-8B; Signal Transduction; Skin

2018
IL-35 recombinant protein reverses inflammatory bowel disease and psoriasis through regulation of inflammatory cytokines and immune cells.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:2

    Topics: Acute Disease; Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukins; Lymphocytes; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Psoriasis; Recombinant Proteins; T-Lymphocytes; Vascular Endothelial Growth Factor A

2018
Interleukin-21 receptor signalling is not critically required for imiquimod-induced psoriasiform dermatitis in mice.
    Experimental dermatology, 2018, Volume: 27, Issue:2

    Topics: Animals; CD4-Positive T-Lymphocytes; Dermatitis; Imiquimod; Inflammation; Interferon Inducers; Interleukin-21 Receptor alpha Subunit; Interleukin-23 Subunit p19; Intraepithelial Lymphocytes; Mice; Mice, Knockout; Mice, Transgenic; Psoriasis; Receptors, Interleukin-21; Signal Transduction

2018
High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice.
    Experimental dermatology, 2018, Volume: 27, Issue:2

    Topics: Animals; Body Weight; Cholesterol; Cytokines; Dermatitis; Diet, High-Fat; Disease Models, Animal; Disease Progression; Hyperlipidemias; Imiquimod; Inflammasomes; Inflammation; Male; Mice; Mice, Inbred C57BL; Neutrophils; Psoriasis; Skin

2018
Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.
    PloS one, 2017, Volume: 12, Issue:12

    Topics: Acetophenones; Adjuvants, Immunologic; Adolescent; Adult; Aminoquinolines; Animals; Apoptosis; Autophagy; Benzopyrans; Cell Proliferation; Cells, Cultured; Female; Humans; Imiquimod; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Middle Aged; NF-kappa B; Psoriasis; Reactive Oxygen Species; Young Adult

2017
The expression of mCTLA-4 in skin lesion inversely correlates with the severity of psoriasis.
    Journal of dermatological science, 2018, Volume: 89, Issue:3

    Topics: Adult; Aged; Aminoquinolines; Animals; Biopsy; CTLA-4 Antigen; Female; Humans; Imiquimod; Male; Mice; Mice, Inbred BALB C; Middle Aged; Psoriasis; Severity of Illness Index; Skin

2018
NB-UVB irradiation downregulates keratin-17 expression in keratinocytes by inhibiting the ERK1/2 and STAT3 signaling pathways.
    Archives of dermatological research, 2018, Volume: 310, Issue:2

    Topics: Aminoquinolines; Animals; Apoptosis; Biomarkers; Cell Line; Cell Proliferation; Disease Models, Animal; Down-Regulation; Female; Healthy Volunteers; Humans; Imiquimod; Keratin-17; Keratinocytes; Keratins; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Primary Cell Culture; Psoriasis; Radiation Dosage; Signal Transduction; Skin; STAT3 Transcription Factor; Treatment Outcome; Ultraviolet Therapy

2018
Antiproliferation of keratinocytes and alleviation of psoriasis by the ethanol extract of Artemisia capillaris.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:5

    Topics: Aminoquinolines; Animals; Apoptosis; Artemisia; Cell Line; Cell Proliferation; Disease Models, Animal; Ethanol; Female; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Plant Extracts; Psoriasis

2018
Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties.
    Colloids and surfaces. B, Biointerfaces, 2018, Apr-01, Volume: 164

    Topics: Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Antioxidants; Betamethasone; Cell Death; Cell Line; Cell Survival; Disease Models, Animal; Drug Compounding; Drug Liberation; Ear; Edema; Humans; Imiquimod; Inflammation; Keratinocytes; Lipids; Mice, Inbred BALB C; Nanoparticles; Particle Size; Permeability; Psoriasis; Rheology; Skin; Sus scrofa; Thymol

2018
Cryptotanshinone reduces psoriatic epidermal hyperplasia via inhibiting the activation of STAT3.
    Experimental dermatology, 2018, Volume: 27, Issue:3

    Topics: Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Drugs, Chinese Herbal; Epidermis; Humans; Hyperplasia; Imiquimod; Keratinocytes; Male; Mice, Inbred C57BL; Phenanthrenes; Psoriasis; STAT3 Transcription Factor

2018
IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis.
    Protein & cell, 2018, Volume: 9, Issue:12

    Topics: Animals; Cell Polarity; Imiquimod; Interleukin-23; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis

2018
Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation.
    Journal of translational medicine, 2018, 03-10, Volume: 16, Issue:1

    Topics: Amyloid Precursor Protein Secretases; Animals; Cell Differentiation; Dipeptides; Down-Regulation; Imiquimod; Inflammation; Interleukin-17; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Receptors, Notch; RNA, Messenger; Skin; Splenomegaly; Th17 Cells

2018
p38α signaling in Langerhans cells promotes the development of IL-17-producing T cells and psoriasiform skin inflammation.
    Science signaling, 2018, 03-13, Volume: 11, Issue:521

    Topics: Animals; Cells, Cultured; Dendritic Cells; Disease Models, Animal; Imidazoles; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Interleukin-6; Langerhans Cells; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 14; Psoriasis; Pyridines; Signal Transduction; Skin; T-Lymphocytes; Th17 Cells

2018
Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice.
    Acta dermato-venereologica, 2018, Jun-08, Volume: 98, Issue:6

    Topics: 5-Methylcytosine; Aminoquinolines; Animals; Case-Control Studies; Cell Differentiation; Cell Proliferation; Chemokine CXCL1; Dioxygenases; Disease Models, Animal; Disease Progression; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Humans; Imiquimod; Interferon-gamma; Interleukin-17; Mice, Inbred BALB C; Proto-Oncogene Proteins; Psoriasis; Skin; Time Factors

2018
Anti-IL-12/IL-23p40 antibody ameliorates dermatitis and skin barrier dysfunction in mice with imiquimod-induced psoriasis-like dermatitis.
    European journal of pharmacology, 2018, Jun-05, Volume: 828

    Topics: Aminoquinolines; Animals; Antibodies, Monoclonal; Cell Proliferation; Dermatitis; Imiquimod; Interleukin-12; Interleukin-23; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2018
Imiquimod-Induced Psoriasis-Like Skin Lesions Do Not Accelerate Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice.
    The American journal of pathology, 2018, Volume: 188, Issue:6

    Topics: Animals; Atherosclerosis; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Knockout; Psoriasis; Receptors, LDL; Skin Diseases

2018
TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:8

    Topics: Animals; CD4-Positive T-Lymphocytes; Cell Line; Disease Models, Animal; Female; Humans; Imiquimod; Male; Mice; Mice, Knockout; Neurons; Oximes; Psoriasis; Skin; TRPA1 Cation Channel; TRPV Cation Channels

2018
8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model.
    Acta dermato-venereologica, 2018, Jun-08, Volume: 98, Issue:6

    Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Imiquimod; Methoxsalen; Mice, Inbred BALB C; Photosensitizing Agents; Psoriasis; PUVA Therapy; Signal Transduction; Skin; Time Factors

2018
Topical heat shock protein 70 prevents imiquimod-induced psoriasis-like inflammation in mice.
    Cell stress & chaperones, 2018, Volume: 23, Issue:5

    Topics: Administration, Cutaneous; Animals; Cytokines; HSP70 Heat-Shock Proteins; Imiquimod; Inflammation; Mice, Inbred BALB C; Psoriasis; Skin Cream

2018
MAPK Phosphatase-1 Deficiency Exacerbates the Severity of Imiquimod-Induced Psoriasiform Skin Disease.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; Cytokines; Dual Specificity Phosphatase 1; Imiquimod; Inflammation Mediators; Macrophages; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Severity of Illness Index; Skin; Skin Diseases

2018
An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation.
    Immunity, 2018, 04-17, Volume: 48, Issue:4

    Topics: Animals; Cell Line; Cell Proliferation; Enzyme Activation; HEK293 Cells; Humans; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Interleukin; Receptors, Interleukin-17; Skin; STAT3 Transcription Factor

2018
Resident and monocyte-derived Langerhans cells are required for imiquimod-induced psoriasis-like dermatitis model.
    Journal of dermatological science, 2018, Volume: 91, Issue:1

    Topics: Aminoquinolines; Animals; Antigens, CD; Cytokines; Dendritic Cells; Disease Models, Animal; Epidermal Cells; Epidermis; Female; Gene Expression Profiling; Humans; Imiquimod; Langerhans Cells; Lectins, C-Type; Male; Mannose-Binding Lectins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocytes; Psoriasis

2018
RIPK1 downregulation in keratinocyte enhances TRAIL signaling in psoriasis.
    Journal of dermatological science, 2018, Volume: 91, Issue:1

    Topics: Aminoquinolines; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Down-Regulation; Epidermal Cells; Epidermis; Female; Gene Knockdown Techniques; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred C57BL; Primary Cell Culture; Psoriasis; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand

2018
Glabridin, an isoflavan from licorice root, ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice.
    International immunopharmacology, 2018, Volume: 59

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cytokines; Glycyrrhiza; Humans; Imiquimod; Isoflavones; Mice, Inbred BALB C; Nitric Oxide; Oxidative Stress; Phenols; Plant Roots; Psoriasis

2018
Topically applied azaphenothiazines inhibit experimental psoriasis in mice.
    International immunopharmacology, 2018, Volume: 59

    Topics: Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Caspases; Cell Line; Cytokines; Disease Models, Animal; fas Receptor; Female; HCT116 Cells; Humans; Imiquimod; Jurkat Cells; Leukocyte Count; Lipopolysaccharides; Mice, Inbred BALB C; NF-kappa B; Phenothiazines; Psoriasis; Skin

2018
Thromboxane A
    The Journal of allergy and clinical immunology, 2018, Volume: 142, Issue:2

    Topics: Animals; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Receptors, G-Protein-Coupled; Receptors, Thromboxane A2, Prostaglandin H2; T-Lymphocytes; Thromboxane A2; Thromboxane-A Synthase

2018
The Therapeutic Potential and Molecular Mechanism of Isoflavone Extract against Psoriasis.
    Scientific reports, 2018, 04-20, Volume: 8, Issue:1

    Topics: Animals; Antioxidants; Cytokines; Disease Models, Animal; Epidermis; Foreskin; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukins; Isoflavones; Keratinocytes; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Signal Transduction; Skin; Tumor Necrosis Factor-alpha

2018
Gold lotion from citrus peel extract ameliorates imiquimod-induced psoriasis-like dermatitis in murine.
    Journal of the science of food and agriculture, 2018, Volume: 98, Issue:14

    Topics: Aminoquinolines; Animals; Citrus; Cytokines; Dermatitis; Fruit; Humans; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Psoriasis

2018
NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis.
    Cellular immunology, 2018, Volume: 331

    Topics: Adult; Animals; Cell Line; Cells, Cultured; Cytokines; Female; Humans; Imiquimod; Interleukin-17; Male; Mice, Inbred BALB C; Middle Aged; NF-kappa B p50 Subunit; Psoriasis; Skin; Th1 Cells; Young Adult

2018
IDO-expressing Fibroblasts Suppress the Development of Imiquimod-induced Psoriasis-like Dermatitis.
    Cell transplantation, 2018, Volume: 27, Issue:3

    Topics: Animals; Dermatitis; Female; Fibroblasts; Flow Cytometry; Imiquimod; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis

2018
Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model.
    Experimental dermatology, 2018, Volume: 27, Issue:9

    Topics: Animals; Calgranulin A; Calgranulin B; Cell Proliferation; Cytokines; Disease Models, Animal; Epidermis; Humans; Imiquimod; Keratinocytes; Membrane Proteins; Mice; Mice, Knockout; Protective Factors; Proteins; Psoriasis; RNA, Messenger; Skin

2018
Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation.
    Cell death & disease, 2018, 05-22, Volume: 9, Issue:6

    Topics: Animals; Cell Differentiation; Cell Proliferation; Epidermis; Gene Expression Regulation; Glucocorticoids; Imiquimod; Inflammation; Keratinocytes; Mice, Knockout; NF-kappa B; Phenotype; Phosphorylation; Psoriasis; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Signal Transduction; Tetradecanoylphorbol Acetate

2018
IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
    Journal of immunology (Baltimore, Md. : 1950), 2018, 07-01, Volume: 201, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cells, Cultured; Chemokines; Colitis; Dendritic Cells; Dextran Sulfate; Fibroblasts; Imiquimod; Interleukin-1; Keratinocytes; Langerhans Cells; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Skin; Th17 Cells; Toll-Like Receptor 7; Toll-Like Receptor 8

2018
Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro.
    Life sciences, 2018, Aug-15, Volume: 207

    Topics: Aminoquinolines; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Proliferation; Coculture Techniques; Cytokines; Dendritic Cells; Erythema; Imiquimod; Inflammation; Interleukin-12 Subunit p35; Interleukin-23 Subunit p19; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Psoriasis; RNA, Messenger; Signal Transduction; Spleen; Toll-Like Receptor 7; Toll-Like Receptor 8; Triterpenes

2018
Extracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:12

    Topics: Adenosine Triphosphate; Animals; Dermatitis; Disease Models, Animal; Extracellular Space; Female; Humans; Imiquimod; Inflammation Mediators; Interleukin-17; Interleukin-1beta; Interleukin-23; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Receptors, Purinergic P2X7; Signal Transduction; Skin

2018
C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes.
    Scientific reports, 2018, 06-05, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Animals; Antimicrobial Cationic Peptides; Cell Line; Cell Proliferation; Child; Disease Models, Animal; DNA-Binding Proteins; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression; Humans; Imiquimod; Keratinocytes; Male; Mice, Inbred BALB C; Middle Aged; Psoriasis; RNA Interference; Signal Transduction; Skin; Young Adult

2018
Mild electrical stimulation with heat shock reduces inflammatory symptoms in the imiquimod-induced psoriasis mouse model.
    Experimental dermatology, 2018, Volume: 27, Issue:10

    Topics: Animals; beta-Defensins; Calgranulin A; Calgranulin B; CD3 Complex; Cell Line; Cell Movement; Cell Proliferation; Combined Modality Therapy; Disease Models, Animal; Electric Stimulation Therapy; Female; Gene Expression; Humans; Hyperplasia; Hyperthermia, Induced; Imiquimod; Interleukin-17; Keratinocytes; Mice; Pancreatitis-Associated Proteins; Psoriasis; RNA, Messenger; Skin; T-Lymphocytes

2018
Decryption of Active Constituents and Action Mechanism of the Traditional Uighur Prescription (BXXTR) Alleviating IMQ-Induced Psoriasis-Like Skin Inflammation in BALB/c Mice.
    International journal of molecular sciences, 2018, Jun-21, Volume: 19, Issue:7

    Topics: Aminoquinolines; Animals; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Humans; Imiquimod; Interleukin-17; Interleukin-18; Interleukin-23; Keratinocytes; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Psoriasis; Severity of Illness Index; Signal Transduction; Skin; Toll-Like Receptor 8; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2018
Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.
    Immunity, 2018, 07-17, Volume: 49, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; CARD Signaling Adaptor Proteins; Cell Line; Cytokines; Dermatitis; Gain of Function Mutation; Gene Expression Regulation; Guanylate Kinases; HEK293 Cells; Humans; Imiquimod; Interleukin-17; Keratinocytes; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Psoriasis; Signal Transduction; T-Lymphocyte Subsets; TNF Receptor-Associated Factor 6

2018
Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:1

    Topics: Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Keratinocytes; Membrane Proteins; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Psoriasis; RNA; Signal Transduction; Skin

2019
miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A.
    Journal of immunology (Baltimore, Md. : 1950), 2018, 09-01, Volume: 201, Issue:5

    Topics: 3' Untranslated Regions; Animals; Down-Regulation; Female; Humans; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; MicroRNAs; Psoriasis

2018
Rapamycin ameliorates psoriasis by regulating the expression and methylation levels of tropomyosin via ERK1/2 and mTOR pathways in vitro and in vivo.
    Experimental dermatology, 2018, Volume: 27, Issue:10

    Topics: Animals; Cell Proliferation; Cytoskeleton; Down-Regulation; Female; Gene Expression; HEK293 Cells; Humans; Imiquimod; Immunosuppressive Agents; Keratinocytes; Male; MAP Kinase Signaling System; Methylation; Mice; Psoriasis; S Phase Cell Cycle Checkpoints; Sirolimus; TOR Serine-Threonine Kinases; Tropomyosin

2018
Chlamydial Plasmid-Encoded Protein pGP3 Inhibits Development of Psoriasis-Like Lesions in Mice.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Jul-25, Volume: 24

    Topics: Aminoquinolines; Animals; Antigens, Bacterial; Antimicrobial Cationic Peptides; Bacterial Proteins; Cathelicidins; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin

2018
Chitosan-based nanoformulated (-)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Administration, Topical; Aminoquinolines; Animals; Antineoplastic Agents; Antioxidants; Catechin; Cell Differentiation; Cells, Cultured; Chitosan; Dermatitis; Filaggrin Proteins; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Nanoparticles; Psoriasis

2018
Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation.
    JCI insight, 2018, 08-09, Volume: 3, Issue:15

    Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-17; Intraepithelial Lymphocytes; Keratinocytes; Male; Mice; Mice, Knockout; Primary Cell Culture; Psoriasis; Receptors, Interleukin-17; Signal Transduction; Skin; TNF Receptor-Associated Factor 6

2018
Local production of prolactin in lesions may play a pathogenic role in psoriatic patients and imiquimod-induced psoriasis-like mouse model.
    Experimental dermatology, 2018, Volume: 27, Issue:11

    Topics: Adult; Aged; Animals; Cabergoline; Cytokines; Dermis; Disease Models, Animal; Dopamine Agonists; Epidermis; Female; Humans; Imiquimod; Male; Methylcellulose; Mice; Middle Aged; Prolactin; Psoriasis; Receptors, Prolactin; Risk Adjustment; RNA, Messenger; Solvents; TRPV Cation Channels

2018
Tetrathiomolybdate, a copper chelator inhibited imiquimod-induced skin inflammation in mice.
    Journal of dermatological science, 2018, Volume: 92, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Chelating Agents; Copper; Cytokines; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Imiquimod; Inflammation Mediators; Keratinocytes; Male; Mice, Inbred C57BL; Molybdenum; Phosphorylation; Psoriasis; Signal Transduction; Skin; Spleen; STAT3 Transcription Factor

2018
Overexpression of Wilms' tumor 1 in skin lesions of psoriasis is associated with abnormal proliferation and apoptosis of keratinocytes.
    Molecular medicine reports, 2018, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Animals; Apoptosis; Case-Control Studies; Cell Proliferation; Disease Models, Animal; Female; Gene Knockdown Techniques; Humans; Imiquimod; Inflammation; Keratinocytes; Male; Mice, Inbred BALB C; Middle Aged; Psoriasis; Skin; WT1 Proteins; Young Adult

2018
Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice.
    Biomaterials, 2018, Volume: 182

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Curcumin; Dermatitis; Drug Carriers; Imiquimod; Lipids; Male; Mice; Nanofibers; Psoriasis

2018
The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Nov-01, Volume: 124

    Topics: Animals; Benzofurans; Coumarins; Female; Furocoumarins; Imiquimod; Keratinocytes; Mice, Inbred BALB C; Mice, Nude; Phenols; Photochemotherapy; Psoralea; Psoriasis; PUVA Therapy; Skin; Skin Absorption; Swine; Ultraviolet Rays

2018
Dendrimer as a new potential carrier for topical delivery of siRNA: A comparative study of dendriplex vs. lipoplex for delivery of TNF-α siRNA.
    International journal of pharmaceutics, 2018, Oct-25, Volume: 550, Issue:1-2

    Topics: Animals; Cytokines; Dendrimers; Fatty Acids, Monounsaturated; Gene Transfer Techniques; Imiquimod; Liposomes; Mice, Inbred BALB C; Psoriasis; Quaternary Ammonium Compounds; RNA, Small Interfering; Skin

2018
The vitamin D
    Journal of dermatological science, 2018, Volume: 92, Issue:2

    Topics: Adoptive Transfer; Animals; Betamethasone Valerate; Calcitriol; Dermatologic Agents; Down-Regulation; Female; Humans; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Psoriasis; Skin; T-Lymphocytes, Regulatory; Treatment Outcome

2018
Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Aug-01, Volume: 47

    Topics: Administration, Cutaneous; Aminoquinolines; Angelica sinensis; Animals; Cell Line; Cell Proliferation; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Imiquimod; Inflammation; Interleukin-22; Interleukins; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Th17 Cells; Tumor Necrosis Factor-alpha

2018
Is CCR6 Required for the Development of Psoriasiform Dermatitis in Mice?
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:2

    Topics: Administration, Cutaneous; Animals; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Knockout; Psoriasis; Receptors, CCR6; Skin

2019
[Effect of methotrexate on regulation for the number of regulatory T cells and expression of Foxp3 in psoriasis].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2018, Aug-28, Volume: 43, Issue:8

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Case-Control Studies; Female; Forkhead Transcription Factors; Humans; Imiquimod; Immunosuppressive Agents; Lymphocyte Count; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Random Allocation; RNA, Messenger; Spleen; T-Lymphocytes, Regulatory

2018
Epidermal mast cells in Bowenoid papulosis during topical imiquimod therapy.
    The Journal of dermatology, 2019, Volume: 46, Issue:4

    Topics: Administration, Cutaneous; Aged; Biopsy; Bowen's Disease; Epidermis; Glucocorticoids; Humans; Imiquimod; Male; Mast Cells; Psoriasis; Scrotum; Skin Neoplasms; Treatment Outcome

2019
Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:2

    Topics: Animals; Calcitonin Gene-Related Peptide; Denervation; Disease Models, Animal; Diterpenes; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Psoriasis; Reactive Nitrogen Species; Reactive Oxygen Species; Sensory Receptor Cells; Skin; Substance P; TRPA1 Cation Channel; TRPV Cation Channels

2019
5-hydroxytryptophan attenuates imiquimod-induced psoriasiform dermatitis probably through inhibition of IL-17A production and keratinocyte activation.
    Experimental dermatology, 2018, Volume: 27, Issue:11

    Topics: 5-Hydroxytryptophan; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Epidermis; Humans; Imiquimod; Interferon-gamma; Interleukin-17; Interleukin-6; Keratinocytes; Ki-67 Antigen; Male; Mice; Mice, Inbred C57BL; Protein Biosynthesis; Psoriasis; Spleen; Tumor Necrosis Factor-alpha

2018
Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice.
    International immunopharmacology, 2018, Volume: 64

    Topics: Animals; Anti-Inflammatory Agents; CD8-Positive T-Lymphocytes; Cyclooxygenase 2; Cytokines; Female; Imiquimod; Ketones; Mice; Mice, Inbred BALB C; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Psoriasis; Sesquiterpenes

2018
Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; CD8-Positive T-Lymphocytes; Cytokines; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; T-Lymphocytes, Regulatory; Umbelliferones

2018
A requirement for slc15a4 in imiquimod-induced systemic inflammation and psoriasiform inflammation in mice.
    Scientific reports, 2018, 09-27, Volume: 8, Issue:1

    Topics: Animals; Cytokines; Dermatitis; Disease Models, Animal; Imiquimod; Inflammation; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Transgenic; Psoriasis; Skin; Toll-Like Receptor 7

2018
Downregulation of miR-145-5p contributes to hyperproliferation of keratinocytes and skin inflammation in psoriasis.
    The British journal of dermatology, 2019, Volume: 180, Issue:2

    Topics: Adult; Animals; Antagomirs; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Down-Regulation; Female; Gene Expression Profiling; Humans; Imiquimod; Keratinocytes; Male; MAP Kinase Kinase Kinases; Mice; MicroRNAs; Mitogen-Activated Protein Kinase Kinase Kinase 11; Oligonucleotide Array Sequence Analysis; Primary Cell Culture; Psoriasis; Skin; Young Adult

2019
Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred C57BL; Nanoparticles; Psoriasis; Skin

2018
Macrophages express βKlotho in skin lesions of psoriatic patients and the skin of imiquimod-treated mice.
    The Journal of dermatology, 2018, Volume: 45, Issue:12

    Topics: Adult; Aged; Animals; Antibodies, Neutralizing; Case-Control Studies; Dermatitis, Atopic; Disease Models, Animal; Down-Regulation; Female; Humans; Imiquimod; Immunohistochemistry; Interleukin-17; Klotho Proteins; Macrophages; Male; Membrane Proteins; Mice; Middle Aged; Psoriasis; Skin

2018
The small molecule rhodomyrtone suppresses TNF-α and IL-17A-induced keratinocyte inflammatory responses: A potential new therapeutic for psoriasis.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Mice; NF-kappa B; Organ Culture Techniques; Psoriasis; Signal Transduction; Skin; Tumor Necrosis Factor-alpha; Xanthones

2018
    Frontiers in immunology, 2018, Volume: 9

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Interleukin-23; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Mice; Mice, Knockout; Psoriasis; Skin

2018
IL-36α is involved in hapten-specific T-cell induction, but not local inflammation, during contact hypersensitivity.
    Biochemical and biophysical research communications, 2018, 11-30, Volume: 506, Issue:3

    Topics: Animals; Cell Movement; Dendritic Cells; Dermatitis; Dermatitis, Contact; Haptens; Imiquimod; Inflammation; Interleukin-1; Keratinocytes; Lymph Nodes; Mice, Inbred C57BL; Psoriasis; Skin; T-Lymphocytes

2018
Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:3

    Topics: Animals; Antibodies, Blocking; Aorta; Disease Models, Animal; Disease Progression; Humans; Imiquimod; Immunotherapy; Inflammation; Interleukin-17; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Oxidative Stress; Psoriasis; Reactive Oxygen Species; Skin; Vascular Diseases

2019
Ameliorative effects of a fusion protein dual targeting interleukin 17A and tumor necrosis factor α on imiquimod-induced psoriasis in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108

    Topics: Animals; Antigens, Ly; Caspase 14; Etanercept; Female; Filaggrin Proteins; Imiquimod; Interleukin-17; Intermediate Filament Proteins; Keratin-16; Keratin-17; Keratin-6; Mice; Mice, Inbred BALB C; Psoriasis; Tumor Necrosis Factor-alpha

2018
IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment.
    Cell death & disease, 2018, 10-30, Volume: 9, Issue:11

    Topics: Adolescent; Adult; Aged; Animals; Antibodies, Monoclonal, Humanized; Case-Control Studies; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Regulation; Humans; Imiquimod; Immunologic Factors; Interleukin-1; Interleukin-17; Interleukins; Keratinocytes; Male; Mice; Middle Aged; Primary Cell Culture; Psoriasis; Receptors, Interleukin-1; Severity of Illness Index; Signal Transduction; Skin

2018
Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases.
    Pharmacology research & perspectives, 2018, Volume: 6, Issue:6

    Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aza Compounds; Disease Models, Animal; Fatty Acids, Omega-3; Humans; Imiquimod; Mice; Mice, Inbred C57BL; Pemphigoid, Bullous; Psoriasis; Receptors, G-Protein-Coupled; Treatment Outcome

2018
Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis.
    Acta dermato-venereologica, 2019, Mar-01, Volume: 99, Issue:3

    Topics: Animals; Antipruritics; Behavior, Animal; Disease Models, Animal; Imiquimod; Interleukin-22; Interleukin-23; Interleukins; Janus Kinase Inhibitors; Male; Mice, Inbred C57BL; Nerve Fibers; Piperidines; Pruritus; Psoriasis; Pyrimidines; Pyrroles; Skin

2019
ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway.
    International immunopharmacology, 2019, Volume: 66

    Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; Humans; Imiquimod; Interleukin-12; Interleukin-17; Interleukin-6; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors; Psoriasis; raf Kinases; Signal Transduction; Skin; Small Molecule Libraries; Th17 Cells

2019
Ascorbic acid derivative DDH-1 ameliorates psoriasis-like skin lesions in mice by suppressing inflammatory cytokine expression.
    Journal of pharmacological sciences, 2018, Volume: 138, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Ascorbic Acid; Cytokines; Female; Imiquimod; Mice, Inbred C57BL; Psoriasis; Skin

2018
Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.
    Cellular and molecular gastroenterology and hepatology, 2019, Volume: 7, Issue:1

    Topics: Animals; B-Lymphocytes; Cell Movement; Colitis; Dermatitis; Dextran Sulfate; Disease Progression; Fecal Microbiota Transplantation; Female; Gastrointestinal Microbiome; Hematopoietic Stem Cells; Imiquimod; Immunoglobulin D; Immunoglobulin M; Intestines; Lactobacillus; Lymph Nodes; Lymphocyte Depletion; Mice, Inbred C57BL; Permeability; Psoriasis; Toll-Like Receptor 7

2019
TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice.
    Journal of dermatological science, 2018, Volume: 92, Issue:3

    Topics: Animals; Cytokines; Disease Models, Animal; Epidermis; Female; Humans; Hyperplasia; Imiquimod; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; TRPV Cation Channels; Water Loss, Insensible

2018
Anti-psoriatic effect of myeloid-derived suppressor cells on imiquimod-induced skin inflammation in mice.
    Scandinavian journal of immunology, 2019, Volume: 89, Issue:3

    Topics: Animals; Cytokines; Dermatitis; Female; Imiquimod; Mice; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Psoriasis; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells

2019
Rutaecarpine inhibited imiquimod-induced psoriasis-like dermatitis via inhibiting the NF-κB and TLR7 pathways in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 109

    Topics: Animals; Dermatitis; Disease Models, Animal; Imiquimod; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Quinazolines; Signal Transduction; Skin; Skin Diseases; Th17 Cells; Toll-Like Receptor 7

2019
Disinhibition of Touch-Evoked Itch in a Mouse Model of Psoriasis.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:6

    Topics: Animals; Disease Models, Animal; Epidermis; Humans; Imiquimod; Interneurons; Male; Merkel Cells; Mice; Neurofilament Proteins; Pruritus; Psoriasis; Touch

2019
A Western Diet, but Not a High-Fat and Low-Sugar Diet, Predisposes Mice to Enhanced Susceptibility to Imiquimod-Induced Psoriasiform Dermatitis.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:6

    Topics: Animals; Diet, Carbohydrate-Restricted; Diet, High-Fat; Diet, Western; Dietary Sugars; Disease Models, Animal; Disease Susceptibility; Female; Humans; Imiquimod; Mice; Obesity; Psoriasis

2019
Structure-based drug designing and identification of Woodfordia fruticosa inhibitors targeted against heat shock protein (HSP70-1) as suppressor for Imiquimod-induced psoriasis like skin inflammation in mice model.
    Materials science & engineering. C, Materials for biological applications, 2019, Feb-01, Volume: 95

    Topics: Animals; Disease Models, Animal; Gold; Heat-Shock Proteins; Humans; Imiquimod; Metal Nanoparticles; Mice; Molecular Docking Simulation; Psoriasis; Skin Diseases; Woodfordia

2019
Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation.
    Cell reports, 2018, 12-26, Volume: 25, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Animals; Female; Forkhead Transcription Factors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imiquimod; Inflammation; Male; Mice, Inbred C57BL; Middle Aged; Neutralization Tests; Phagocytes; Psoriasis; Receptors, Antigen, T-Cell, alpha-beta; Skin; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory

2018
Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
    EBioMedicine, 2019, Volume: 39

    Topics: Administration, Topical; Allosteric Site; Animals; Carbon; Cell Line; Down-Regulation; Humans; Imiquimod; Keratinocytes; Male; Metabolomics; Methionine Adenosyltransferase; Mice; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Psoriasis; Triterpenes

2019
IL-23- and Imiquimod-Induced Models of Experimental Psoriasis in Mice.
    Current protocols in immunology, 2019, Volume: 125, Issue:1

    Topics: Adjuvants, Immunologic; Administration, Topical; Animals; Cytokines; Disease Models, Animal; Flow Cytometry; Imiquimod; Injections, Intradermal; Interleukin-23; Mice; Psoriasis; Skin

2019
Human amnion-derived mesenchymal stem cells ameliorate imiquimod-induced psoriasiform dermatitis in mice.
    The Journal of dermatology, 2019, Volume: 46, Issue:3

    Topics: Amnion; Animals; Cells, Cultured; Chemokines; Culture Media, Conditioned; Disease Models, Animal; Humans; Imiquimod; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Primary Cell Culture; Psoriasis; Skin; Treatment Outcome; Umbilical Cord

2019
Mechanical Stretch Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:7

    Topics: Animals; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Epidermis; Humans; Imiquimod; Inflammation Mediators; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Stress, Mechanical; Tight Junctions

2019
Downregulated Caveolin-1 expression in circulating monocytes may contribute to the pathogenesis of psoriasis.
    Scientific reports, 2019, 01-15, Volume: 9, Issue:1

    Topics: Animals; Caveolin 1; Chemotaxis; Down-Regulation; Humans; Imiquimod; Inflammation; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Mice; Monocytes; Psoriasis

2019
Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway.
    Life sciences, 2019, Feb-15, Volume: 219

    Topics: Animals; Blotting, Western; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Hesperidin; Humans; Imiquimod; Keratinocytes; Lipopolysaccharides; Male; MAP Kinase Signaling System; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Real-Time Polymerase Chain Reaction

2019
Cold atmospheric plasma ameliorates imiquimod-induced psoriasiform dermatitis in mice by mediating antiproliferative effects.
    Free radical research, 2019, Volume: 53, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Dermatitis; Female; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Plasma Gases; Psoriasis

2019
Imiquimod-Induced Psoriasis in Mice Depends on the IL-17 Signaling of Keratinocytes.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:5

    Topics: Adjuvants, Immunologic; Animals; Biopsy, Needle; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Flow Cytometry; Imiquimod; Immunohistochemistry; Interleukin-17; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Psoriasis; Random Allocation; Real-Time Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha

2019
Ghrelin protects against contact dermatitis and psoriasiform skin inflammation by antagonizing TNF-α/NF-κB signaling pathways.
    Scientific reports, 2019, 02-04, Volume: 9, Issue:1

    Topics: Animals; Dermatitis, Contact; Disease Models, Animal; Fibroblasts; Gene Expression Regulation; Ghrelin; Humans; Imiquimod; Immune System Diseases; Inflammation; Mice; NF-kappa B; Oxazolone; Psoriasis; RAW 264.7 Cells; Signal Transduction; Skin; Tumor Necrosis Factor-alpha

2019
Interleukin-18 exacerbates skin inflammation and affects microabscesses and scale formation in a mouse model of imiquimod-induced psoriasis.
    Chinese medical journal, 2019, Mar-20, Volume: 132, Issue:6

    Topics: Animals; Chemokine CXCL1; Cytokines; Disease Models, Animal; Imiquimod; Interleukin-17; Interleukin-18; Mice; Mice, Knockout; Psoriasis; Skin

2019
Genistein suppresses psoriasis-related inflammation through a STAT3-NF-κB-dependent mechanism in keratinocytes.
    International immunopharmacology, 2019, Volume: 69

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Disease Models, Animal; Genistein; Heme; Humans; Imiquimod; Inflammation Mediators; Keratinocytes; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A

2019
Dithranol-loaded nanostructured lipid carrier-based gel ameliorate psoriasis in imiquimod-induced mice psoriatic plaque model.
    Drug development and industrial pharmacy, 2019, Volume: 45, Issue:5

    Topics: Administration, Cutaneous; Animals; Anthralin; Dermatologic Agents; Disease Models, Animal; Drug Carriers; Drug Liberation; Gels; Humans; Imiquimod; Lipids; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Ointments; Particle Size; Psoriasis; Severity of Illness Index; Skin; Treatment Outcome

2019
Hyperglycemia Is Associated with Psoriatic Inflammation in Both Humans and Mice.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:6

    Topics: Animals; Blood Glucose; Cross-Sectional Studies; Disease Models, Animal; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Imiquimod; Insulin; Interleukin-17; Male; Mice; Middle Aged; Phototherapy; Psoriasis; Retrospective Studies; Severity of Illness Index; Skin; Treatment Outcome

2019
Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.
    Acta dermato-venereologica, 2019, May-01, Volume: 99, Issue:6

    Topics: Administration, Topical; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Ceramidases; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Imiquimod; Immunity; Inflammation; Interleukin-17; Lysophospholipids; Male; Mice; Phosphotransferases (Alcohol Group Acceptor); Psoriasis; Quinolones; RNA, Messenger; Sphingosine; Suppressor of Cytokine Signaling 1 Protein; Th17 Cells

2019
Methodological refinement of Aldara-induced psoriasiform dermatitis model in mice.
    Scientific reports, 2019, 03-06, Volume: 9, Issue:1

    Topics: Animals; CD11b Antigen; Cytokines; Dermatitis; Disease Models, Animal; Female; Imiquimod; Mice, Inbred C57BL; Petrolatum; Psoriasis

2019
cis-Khellactone Inhibited the Proinflammatory Macrophages via Promoting Autophagy to Ameliorate Imiquimod-Induced Psoriasis.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:9

    Topics: Adjuvants, Immunologic; Animals; Autophagy; Autophagy-Related Protein 7; Beclin-1; Cells, Cultured; Coumarins; Disease Models, Animal; Female; Gene Knockdown Techniques; Hepatocytes; Humans; Imiquimod; Macrophages; Male; Methotrexate; Mice; Mice, Inbred C57BL; Primary Cell Culture; Psoriasis; Toxicity Tests

2019
Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes.
    Cell death & disease, 2019, 03-20, Volume: 10, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Berberine; Cell Cycle Proteins; Cell Line; Cell Proliferation; Disease Models, Animal; Female; Humans; Imiquimod; Janus Kinases; Keratinocytes; Mice; Mice, Inbred BALB C; Nuclear Proteins; Psoriasis; Signal Transduction; STAT3 Transcription Factor; Transfection

2019
Cholecystokinin Downregulates Psoriatic Inflammation by Its Possible Self-Regulatory Effect on Epidermal Keratinocytes.
    Journal of immunology (Baltimore, Md. : 1950), 2019, 05-01, Volume: 202, Issue:9

    Topics: Animals; Autocrine Communication; Cholecystokinin; Down-Regulation; Epidermis; Female; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-6; Keratinocytes; Male; Mice; Oligopeptides; Paracrine Communication; Psoriasis; Signal Transduction

2019
Imiquimod-induced skin inflammation is relieved by knockdown of sodium channel Na
    Experimental dermatology, 2019, Volume: 28, Issue:5

    Topics: Animals; Dermatitis; Epidermis; Female; Gene Knockdown Techniques; Imiquimod; Inflammation; Psoriasis; Rabbits; RNA Interference; Skin; Voltage-Gated Sodium Channels

2019
IL-33 contributes to disease severity in Psoriasis-like models of mouse.
    Cytokine, 2019, Volume: 119

    Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammation; Interleukin-17; Interleukin-33; Interleukins; Mice; Mice, Inbred BALB C; Psoriasis; Skin; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha

2019
Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms.
    International immunopharmacology, 2019, Volume: 71

    Topics: Ambroxol; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Humans; Hyperplasia; Imiquimod; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Psoriasis; RAW 264.7 Cells; Signal Transduction; Skin

2019
GPR15 is not critically involved in the regulation of murine psoriasiform dermatitis.
    Journal of dermatological science, 2019, Volume: 94, Issue:1

    Topics: Animals; Disease Models, Animal; Humans; Imiquimod; Interleukin-23; Mice; Mice, Knockout; Psoriasis; Receptors, G-Protein-Coupled; Skin

2019
IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells.
    Cell reports, 2019, 04-16, Volume: 27, Issue:3

    Topics: Animals; Antibodies; Cell Differentiation; Cytokines; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-1; Interleukin-1 Receptor Accessory Protein; Interleukin-17; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Regeneration; Skin; T-Lymphocytes

2019
Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:5

    Topics: Animals; Imiquimod; Interleukin-17; Keratinocytes; Mice; Psoriasis; Skin

2019
Imiquimod-induced widespread psoriasiform eruptions.
    European journal of dermatology : EJD, 2019, 04-01, Volume: 29, Issue:2

    Topics: Administration, Cutaneous; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Imiquimod; Keratosis, Actinic; Psoriasis

2019
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
    International journal of molecular medicine, 2019, Volume: 44, Issue:1

    Topics: Animals; Cell Line; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Humans; Imiquimod; Mice; Psoriasis; Sirtuins

2019
Ferulic acid altered IL-17A/IL-17RA interaction and protected against imiquimod-induced psoriasis-like skin injury in mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 129

    Topics: Adjuvants, Immunologic; Animals; Coumaric Acids; Female; Imiquimod; Interleukin-17; Mice; Mice, Inbred BALB C; Protein Binding; Psoriasis; Receptors, Interleukin-17

2019
Shikonin induces apoptosis and suppresses growth in keratinocytes via CEBP-δ upregulation.
    International immunopharmacology, 2019, Volume: 72

    Topics: Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-delta; Cell Line; Cell Proliferation; Humans; Imiquimod; Janus Kinases; Keratinocytes; Male; Mice, Inbred BALB C; Naphthoquinones; Psoriasis; STAT3 Transcription Factor; Up-Regulation

2019
Synthesis and identification of quinoline derivatives as topoisomerase I inhibitors with potent antipsoriasis activity in an animal model.
    Bioorganic chemistry, 2019, Volume: 88

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Ear; Imiquimod; Inflammation; Male; Mice, Inbred BALB C; Psoriasis; Quinolines; Skin; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors

2019
Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:7

    Topics: Adult; Animals; Dermis; Epidermis; Female; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Keratosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Physiologic; Psoriasis; RNA, Messenger; Th17 Cells; TRPA1 Cation Channel

2019
A Novel Surfactant-Free O/O Paclitaxel Ointment for the Topical Treatment of Psoriasis.
    AAPS PharmSciTech, 2019, Jun-04, Volume: 20, Issue:5

    Topics: Administration, Topical; Animals; Humans; Imiquimod; Male; Mice; Mice, Inbred BALB C; Ointments; Paclitaxel; Particle Size; Psoriasis; Skin; Surface-Active Agents

2019
[Knockdown of interleukin 20 receptor 2 (IL-20R2) inhibits the development of psoriasis induced by imiquimod in mice].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2019, Volume: 35, Issue:4

    Topics: Animals; Gene Knockdown Techniques; Imiquimod; Mice; Mice, Knockout; Psoriasis; Receptors, Interleukin

2019
Colloidal nanostructured lipid carriers of pentoxifylline produced by microwave irradiation ameliorates imiquimod-induced psoriasis in mice.
    Colloids and surfaces. B, Biointerfaces, 2019, Sep-01, Volume: 181

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colloids; Drug Carriers; Imiquimod; Lipids; Male; Mice; Microwaves; Models, Molecular; Nanostructures; Particle Size; Pentoxifylline; Psoriasis; Rats; Rats, Wistar; Surface Properties

2019
Caspase-11-Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:11

    Topics: Animals; Caspases, Initiator; Cell Death; Cell Proliferation; Disease Models, Animal; Humans; Imiquimod; Inflammation; Interleukin-1beta; Mice; Mice, Knockout; Neovascularization, Pathologic; Psoriasis; Ribonuclease, Pancreatic; Skin

2019
    Molecules (Basel, Switzerland), 2019, Jun-07, Volume: 24, Issue:11

    Topics: Animals; Cytokines; Datura metel; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Gene Expression Regulation; Imiquimod; Male; Membrane Glycoproteins; Mice; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Signal Transduction; Toll-Like Receptor 7; Toll-Like Receptor 8

2019
Ginsenoside compound K ameliorates imiquimod-induced psoriasis-like dermatitis through inhibiting REG3A/RegIIIγ expression in keratinocytes.
    Biochemical and biophysical research communications, 2019, 08-06, Volume: 515, Issue:4

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dermatitis; Female; Ginsenosides; Humans; Imiquimod; Interleukin-1; Keratinocytes; Mice; Mice, Inbred C57BL; Pancreatitis-Associated Proteins; Psoriasis; Skin

2019
Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
    International immunopharmacology, 2019, Volume: 74

    Topics: Animals; Astragalus propinquus; Cell Movement; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Inflammasomes; Inflammation; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Pyroptosis; Sapogenins; Skin

2019
The Psoriasis Therapeutic Potential of a Novel Short Laminin Peptide C16.
    International journal of molecular sciences, 2019, Jun-27, Volume: 20, Issue:13

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Female; Fibronectins; Humans; Imiquimod; Integrin alpha5beta1; Keratinocytes; Laminin; Mice; Mice, Inbred C57BL; Peptide Fragments; Protein Binding; Psoriasis

2019
Mannan-binding lectin promotes keratinocyte to produce CXCL1 and enhances neutrophil infiltration at the early stages of psoriasis.
    Experimental dermatology, 2019, Volume: 28, Issue:9

    Topics: Animals; Cell Line, Transformed; Chemokine CXCL1; Chemotaxis, Leukocyte; Dermis; Female; Humans; Imiquimod; Inflammation; Keratinocytes; Mannose-Binding Lectin; Metabolism, Inborn Errors; Mice; Mice, Knockout; Neutrophils; Psoriasis; Specific Pathogen-Free Organisms; Up-Regulation

2019
E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:1

    Topics: Animals; Cadherins; CD11c Antigen; Cell Differentiation; Cell Movement; Cell Shape; Cells, Cultured; Dermatitis, Contact; Disease Models, Animal; Epidermis; Homeostasis; Humans; Imiquimod; Langerhans Cells; Mice; Mice, Knockout; Psoriasis

2020
Evidence on the direct correlation between miR-31 and IL-22 axis in IMQ-induced psoriasis.
    Experimental dermatology, 2019, Volume: 28, Issue:11

    Topics: Animals; Imiquimod; Interleukin-22; Interleukins; Mice; MicroRNAs; Psoriasis

2019
Anti-psoriasis effect of water-processed rosin in mice.
    Journal of ethnopharmacology, 2019, Oct-05, Volume: 242

    Topics: Abietanes; Animals; Anti-Inflammatory Agents; Cell Proliferation; Cytokines; Female; Imiquimod; Mice, Inbred BALB C; Psoriasis; Resins, Plant; Skin; Spleen; Th1 Cells; Th17 Cells; Water

2019
Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.
    Colloids and surfaces. B, Biointerfaces, 2019, Oct-01, Volume: 182

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biomarkers; Cholesterol; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Female; Hexoses; Imiquimod; Interferon Inducers; Interleukins; Liposomes; Mice; Mice, Inbred C57BL; Pentacyclic Triterpenes; Plant Extracts; Psoriasis; Skin; Spleen; Tripterygium; Triterpenes

2019
Withanolides, Extracted from Datura Metel L. Inhibit Keratinocyte Proliferation and Imiquimod-Induced Psoriasis-Like Dermatitis via the STAT3/P38/ERK1/2 Pathway.
    Molecules (Basel, Switzerland), 2019, Jul-17, Volume: 24, Issue:14

    Topics: Animals; Cell Proliferation; Datura metel; Dermatitis; Humans; Imiquimod; Keratinocytes; MAP Kinase Signaling System; Mice; Psoriasis; STAT3 Transcription Factor; Withanolides

2019
Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation.
    Journal of ethnopharmacology, 2019, Oct-28, Volume: 243

    Topics: Animals; Cytokines; Disease Models, Animal; Female; Glucosides; Guinea Pigs; Imiquimod; Male; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Paeonia; Phosphorylation; Plant Roots; Psoriasis; STAT1 Transcription Factor; STAT3 Transcription Factor

2019
Anti-IL-17A and IL-23p19 antibodies but not anti-TNFα antibody induce expansion of regulatory T cells and restoration of their suppressive function in imiquimod-induced psoriasiform dermatitis.
    Journal of dermatological science, 2019, Volume: 95, Issue:3

    Topics: Adoptive Transfer; Animals; Antibodies, Monoclonal; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-17; Interleukin-23 Subunit p19; Mice; Psoriasis; Signal Transduction; Skin; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Necrosis Factor-alpha

2019
Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis.
    Journal of dermatological science, 2019, Volume: 95, Issue:3

    Topics: Animals; Antigens, Dermatophagoides; Dermatitis, Atopic; Dietary Supplements; Disease Models, Animal; Eicosanoids; Eicosapentaenoic Acid; Humans; Imiquimod; Lipid Metabolism; Male; Mice; Pruritus; Psoriasis; Skin; Treatment Outcome

2019
Investigating the Role of I Kappa B Kinase ε in the Pathogenesis of Psoriasis.
    Acta dermato-venereologica, 2019, Oct-01, Volume: 99, Issue:11

    Topics: Animals; beta-Defensins; Biopsy; Chemokine CCL20; Chemokine CXCL1; Disease Models, Animal; Humans; I-kappa B Kinase; Imiquimod; Interleukin-17; Mice; Psoriasis; RNA, Messenger; Tumor Necrosis Factor-alpha

2019
ALA-PDT alleviates the psoriasis by inhibiting JAK signalling pathway.
    Experimental dermatology, 2019, Volume: 28, Issue:11

    Topics: Aminolevulinic Acid; Animals; Drug Evaluation, Preclinical; Female; Imiquimod; Interferon-gamma; Janus Kinases; Keratinocytes; Mice, Inbred BALB C; Photochemotherapy; Photosensitizing Agents; Psoriasis; Reactive Oxygen Species; Signal Transduction; Suppressor of Cytokine Signaling Proteins

2019
IL-1R1 signaling facilitates Munro's microabscess formation in psoriasiform imiquimod-induced skin inflammation.
    The Journal of investigative dermatology, 2013, Volume: 133, Issue:6

    Topics: Abscess; Adjuvants, Immunologic; Aminoquinolines; Animals; Animals, Newborn; Chemokine CXCL1; Chemokine CXCL2; Dermis; Drug Eruptions; Epidermal Cells; Humans; Imiquimod; Interleukin-1alpha; Interleukin-1beta; Keratinocytes; Mice; Mice, Knockout; Neutrophils; Primary Cell Culture; Psoriasis; Receptors, Interleukin-1 Type I; Signal Transduction

2013
Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin.
    The American journal of pathology, 2013, Volume: 182, Issue:5

    Topics: Aminoquinolines; Animals; Antimicrobial Cationic Peptides; beta-Defensins; Cathelicidins; CCAAT-Enhancer-Binding Protein-alpha; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Nicotinamide Phosphoribosyltransferase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Psoriasis; Receptor, Insulin; RNA, Messenger; RNA, Small Interfering; S100 Calcium Binding Protein A7; S100 Proteins; Skin; STAT3 Transcription Factor; Toll-Like Receptors; Tumor Necrosis Factor-alpha

2013
Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation.
    Journal of leukocyte biology, 2013, Volume: 94, Issue:4

    Topics: Aminoquinolines; Animals; Antigens, CD19; Antigens, CD1d; B-Lymphocytes, Regulatory; CD4-Positive T-Lymphocytes; CD5 Antigens; Humans; Imiquimod; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-17; Lymph Nodes; Lymphocyte Count; Mice; Mice, Inbred C57BL; Phenotype; Psoriasis; RNA, Messenger; Skin; Spleen

2013
Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.
    Journal of dermatological science, 2013, Volume: 71, Issue:1

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Betamethasone; Calcitriol; Cell Differentiation; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Female; Fingolimod Hydrochloride; Humans; Imiquimod; Keratinocytes; Local Lymph Node Assay; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, SCID; Propylene Glycols; Psoriasis; Receptors, Lysosphingolipid; Skin; Skin Transplantation; Sphingosine; Sphingosine-1-Phosphate Receptors; Time Factors

2013
Mustard seed (Sinapis Alba Linn) attenuates imiquimod-induced psoriasiform inflammation of BALB/c mice.
    The Journal of dermatology, 2013, Volume: 40, Issue:7

    Topics: Aminoquinolines; Animals; Catalase; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Glutathione Peroxidase; Imiquimod; Macrophages; Malondialdehyde; Mice; Mice, Inbred BALB C; Mustard Plant; NF-kappa B p50 Subunit; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Preparations; Psoriasis; Seeds; Spleen; Superoxide Dismutase; T-Lymphocytes

2013
Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Jun-25, Volume: 110, Issue:26

    Topics: Aminoquinolines; Animals; Antigens, Surface; Disease Models, Animal; Imiquimod; Interleukin-23; Langerhans Cells; Lectins, C-Type; Mannose-Binding Lectins; Membrane Glycoproteins; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; Psoriasis; Toll-Like Receptor 7

2013
Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Aminoquinolines; Animals; Cell Proliferation; Curcumin; Ear; Gene Expression Regulation; Imiquimod; Inflammation; Interleukin-1beta; Interleukin-6; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Receptors, CCR6; RNA, Messenger; Skin

2013
[Expression of NLRP3 inflammasome in BALB/c mice with imiquimod-induced psoriasis-like inflammation and therapeutic effect of mustard seed (Sinapis Alba Linn)].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2013, Volume: 33, Issue:9

    Topics: Aminoquinolines; Animals; Carrier Proteins; Caspase 1; Female; Imiquimod; Inflammasomes; Inflammation; Interleukin-18; Interleukin-1beta; Mice; Mice, Inbred BALB C; Mustard Plant; NLR Family, Pyrin Domain-Containing 3 Protein; Phytotherapy; Psoriasis; Seeds

2013
Editorial: are regulatory B10 cells a viable target for autoimmune diseases?
    Journal of leukocyte biology, 2013, Volume: 94, Issue:4

    Topics: Aminoquinolines; Animals; B-Lymphocytes, Regulatory; Humans; Imiquimod; Inflammation; Psoriasis; Skin

2013
TLRs to cytokines: mechanistic insights from the imiquimod mouse model of psoriasis.
    European journal of immunology, 2013, Volume: 43, Issue:12

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Humans; Imiquimod; Membrane Glycoproteins; Mice; Psoriasis; Receptors, Purinergic P1; Toll-Like Receptor 7; Toll-Like Receptor 8

2013
A comparison of the effects of topical treatment of calcipotriol, camptothecin, clobetasol and tazarotene on an imiquimod-induced psoriasis-like mouse model.
    Immunopharmacology and immunotoxicology, 2014, Volume: 36, Issue:1

    Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Calcitriol; Camptothecin; Clobetasol; Dermatologic Agents; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Nicotinic Acids; Psoriasis; Topoisomerase I Inhibitors

2014
Prolactin induces the production of Th17 and Th1 cytokines/chemokines in murine Imiquimod-induced psoriasiform skin.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2014, Volume: 28, Issue:10

    Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Imiquimod; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Prolactin; Psoriasis; Real-Time Polymerase Chain Reaction; Recombinant Proteins; RNA, Messenger; Th1 Cells; Th17 Cells

2014
IL-23 from Langerhans cells is required for the development of imiquimod-induced psoriasis-like dermatitis by induction of IL-17A-producing γδ T cells.
    The Journal of investigative dermatology, 2014, Volume: 134, Issue:7

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Dermatitis, Contact; Disease Models, Animal; Imiquimod; Interleukin-12; Interleukin-17; Interleukin-22; Interleukin-23 Subunit p19; Interleukins; Langerhans Cells; Lymph Nodes; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Receptors, CCR6; RNA, Messenger; Skin; Transplantation Chimera

2014
Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Acetylcysteine; Aminoquinolines; Animals; Dermatitis; Disease Progression; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Hyperbaric Oxygenation; Imiquimod; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, Inbred C57BL; NADPH Oxidases; Naphthoquinones; Psoriasis; Reactive Oxygen Species; T-Lymphocytes, Regulatory

2014
Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis.
    Journal of immunology (Baltimore, Md. : 1950), 2014, May-01, Volume: 192, Issue:9

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Chemotaxis, Leukocyte; Disease Models, Animal; Imiquimod; Immunohistochemistry; Keratinocytes; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Psoriasis; Real-Time Polymerase Chain Reaction; Receptors, Interleukin-8B; Receptors, Leukotriene B4

2014
Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis.
    Molecular medicine reports, 2014, Volume: 9, Issue:6

    Topics: Aminoquinolines; Animals; Cell Differentiation; Cytokines; Disease Models, Animal; Fatty Acids, Omega-3; Female; Imiquimod; Inflammation; Inflammation Mediators; Interleukin-17; Interleukin-23; Keratinocytes; Male; Mice; Mice, Transgenic; Organ Size; Protective Agents; Psoriasis; Spleen; Th17 Cells

2014
Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation.
    Nature, 2014, Jun-05, Volume: 510, Issue:7503

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Female; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukin-23; Interleukins; Langerhans Cells; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; NAV1.8 Voltage-Gated Sodium Channel; Nociceptors; Psoriasis; Sensory Receptor Cells; Skin; T-Lymphocytes; TRPV Cation Channels

2014
TLR-induced cytokines promote effective proinflammatory natural Th17 cell responses.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Jun-15, Volume: 192, Issue:12

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cytokines; Imiquimod; Inflammation; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Nuclear Receptor Subfamily 1, Group F, Member 3; Promyelocytic Leukemia Zinc Finger Protein; Psoriasis; Th17 Cells; Toll-Like Receptor 4

2014
Skin-penetrating methotrexate alleviates imiquimod-induced psoriasiform dermatitis via decreasing IL-17-producing gamma delta T cells.
    Experimental dermatology, 2014, Volume: 23, Issue:7

    Topics: Aminoquinolines; Animals; CD11c Antigen; CD4-Positive T-Lymphocytes; Cytokines; Dermatitis; DNA, Complementary; Female; Imiquimod; Inflammation; Interleukin-17; Interleukin-23; Methotrexate; Mice; Mice, Inbred BALB C; Peptides; Permeability; Psoriasis; Skin

2014
Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.
    Immunity, 2014, Jun-19, Volume: 40, Issue:6

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Aryl Hydrocarbon Hydroxylases; Azo Compounds; Basic Helix-Loop-Helix Transcription Factors; Carbazoles; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytokines; Environmental Exposure; Humans; Imiquimod; Inflammation; Keratinocytes; Mice; Mice, Knockout; Psoriasis; Pyrazoles; Receptors, Aryl Hydrocarbon; Signal Transduction; Skin; Transcription Factors; Up-Regulation

2014
Leukotrienes do not modulate the course of Aldara™-induced psoriasiform dermatitis in mice.
    Acta dermato-venereologica, 2015, Volume: 95, Issue:3

    Topics: Aminoquinolines; Animals; Arachidonate 5-Lipoxygenase; Disease Models, Animal; Imiquimod; Leukotrienes; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Leukotriene B4; Signal Transduction; Skin

2015
Aldara®-induced skin inflammation: studies of patients with psoriasis.
    The British journal of dermatology, 2015, Volume: 172, Issue:2

    Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aminoquinolines; Drug Eruptions; Female; Humans; Imiquimod; Male; Middle Aged; Ointments; Psoriasis

2015
IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Aug-19, Volume: 111, Issue:33

    Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Epidermis; Imiquimod; Interleukin-17; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Real-Time Polymerase Chain Reaction

2014
Aldara-induced psoriasis-like skin inflammation: isolation and characterization of cutaneous dendritic cells and innate lymphocytes.
    Methods in molecular biology (Clifton, N.J.), 2014, Volume: 1193

    Topics: Aminoquinolines; Animals; Cell Separation; Cells, Cultured; Cricetinae; Dendritic Cells; Drug Eruptions; Female; Flow Cytometry; Imiquimod; Immunity, Innate; Lymphocytes; Male; Mice; Psoriasis; Rats; Skin

2014
Specific roles for dendritic cell subsets during initiation and progression of psoriasis.
    EMBO molecular medicine, 2014, Volume: 6, Issue:10

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; Bone Marrow Transplantation; Dendritic Cells; Disease Progression; Flow Cytometry; Humans; Imiquimod; Interleukin-10; Interleukin-23; Langerhans Cells; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Proto-Oncogene Proteins c-jun; Psoriasis; Receptors, Interleukin; Signal Transduction; Skin; Transcription Factors

2014
Nanomiemgel--a novel drug delivery system for topical application--in vitro and in vivo evaluation.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Capsaicin; Cell Proliferation; Diclofenac; Disease Models, Animal; Drug Delivery Systems; Drug Stability; Emulsions; Gels; Humans; Imiquimod; Immunohistochemistry; In Vitro Techniques; Inflammation; Keratinocytes; Micelles; Microdialysis; Microscopy, Atomic Force; Nanoparticles; Organ Size; Permeability; Psoriasis; Rats; Rheology; Skin Absorption; Spleen

2014
Deficiency of both L-selectin and ICAM-1 exacerbates imiquimod-induced psoriasis-like skin inflammation through increased infiltration of antigen presenting cells.
    Clinical immunology (Orlando, Fla.), 2015, Volume: 157, Issue:1

    Topics: Aminoquinolines; Animals; Antigen-Presenting Cells; Cell Movement; Imiquimod; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-17; L-Selectin; Mice; Mice, Knockout; Psoriasis; Real-Time Polymerase Chain Reaction; Severity of Illness Index; Skin

2015
Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by downregulating inflammation.
    International immunopharmacology, 2015, Volume: 24, Issue:2

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cytokines; Female; Glucosides; Imiquimod; Macrophages; Mice, Inbred BALB C; Monoterpenes; Neutrophils; Psoriasis; Skin

2015
Osteopontin deficiency affects imiquimod-induced psoriasis-like murine skin inflammation and lymphocyte distribution in skin, draining lymph nodes and spleen.
    Experimental dermatology, 2015, Volume: 24, Issue:4

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Lymphocyte Count; Lymphocytes; Mice; Mice, Knockout; Osteopontin; Psoriasis; Skin; Spleen; Th17 Cells

2015
Changes in mRNA expression precede changes in microRNA expression in lesional psoriatic skin during treatment with adalimumab.
    The British journal of dermatology, 2015, Volume: 173, Issue:2

    Topics: Adalimumab; Adult; Aged; Aminoquinolines; Animals; Anti-Inflammatory Agents; Case-Control Studies; Down-Regulation; Female; Humans; Imiquimod; Interleukin-8; Irritants; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Middle Aged; Psoriasis; RNA, Messenger

2015
IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.
    Cell proliferation, 2015, Volume: 48, Issue:2

    Topics: Aminoquinolines; Animals; Apoptosis; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Proliferation; Cells, Cultured; Cyclin A; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Enzyme Activation; Epidermal Growth Factor; Humans; Imiquimod; Keratinocytes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Phosphorylation; Psoriasis; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Skin; Tumor Suppressor Protein p53

2015
Glycyrrhizin ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice and inhibits TNF-α-induced ICAM-1 expression via NF-κB/MAPK in HaCaT cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:4

    Topics: Aminoquinolines; Animals; Cell Adhesion; Cell Line; Cell Survival; Female; Glycyrrhizic Acid; Humans; Imiquimod; Inflammation; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phosphorylation; Psoriasis; Signal Transduction; Skin Diseases; Tumor Necrosis Factor-alpha; Up-Regulation

2015
SIRT1 Activation Ameliorates Aldara-Induced Psoriasiform Phenotype and Histology in Mice.
    The Journal of investigative dermatology, 2015, Volume: 135, Issue:7

    Topics: Aminoquinolines; Animals; Biopsy, Needle; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Imiquimod; Immunohistochemistry; Keratinocytes; Mice; Phenotype; Psoriasis; Sensitivity and Specificity; Sirtuin 1; Transcriptional Activation

2015
Obesity exacerbates imiquimod-induced psoriasis-like epidermal hyperplasia and interleukin-17 and interleukin-22 production in mice.
    Experimental dermatology, 2015, Volume: 24, Issue:6

    Topics: Aminoquinolines; Animals; Cell Line; Disease Models, Animal; Epidermis; Female; Humans; Hyperplasia; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Keratinocytes; Male; Membrane Glycoproteins; Mice; Mice, Mutant Strains; Obesity; Pancreatitis-Associated Proteins; Phosphatidylinositol 3-Kinases; Proteins; Psoriasis; Toll-Like Receptor 7

2015
Therapeutic and immunomodulatory effects of glucosamine in combination with low-dose cyclosporine a in a murine model of imiquimod-induced psoriasis.
    European journal of pharmacology, 2015, Jun-05, Volume: 756

    Topics: Aminoquinolines; Animals; Cyclosporine; Dermatitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glucosamine; Imiquimod; Immunomodulation; Mice; Mice, Inbred C57BL; Organ Size; Psoriasis; Spleen; T-Lymphocytes, Regulatory

2015
Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:7

    Topics: Aminoquinolines; Animals; Calcium Channels; Chemotaxis, Leukocyte; Disease Models, Animal; HL-60 Cells; Humans; Imiquimod; In Vitro Techniques; Membrane Proteins; Mice; Mice, Knockout; Neoplasm Proteins; Neutrophil Infiltration; Neutrophils; Psoriasis; RNA, Small Interfering; Signal Transduction; Skin; Stromal Interaction Molecule 1

2015
Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1.
    Experimental dermatology, 2015, Volume: 24, Issue:8

    Topics: Aminoquinolines; Animals; Cell Culture Techniques; Cell Movement; Cells, Cultured; Cellular Microenvironment; Collagen Type I; Cyclooxygenase 2; Cytokines; Dendritic Cells; Dermatitis, Contact; Dinoprostone; Enzyme Induction; Fibroblasts; Humans; Imiquimod; Irritants; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 13; Mice; Mice, Inbred C57BL; Monocytes; Picryl Chloride; Psoriasis; Stromal Cells

2015
Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Jun-01, Volume: 194, Issue:11

    Topics: Aminoquinolines; Animals; Antibodies, Monoclonal; Calgranulin A; Etanercept; Imiquimod; Immunoglobulin G; Inflammation; Infliximab; Interferon Type I; Interleukin-12 Subunit p40; Interleukin-17; Interleukin-23 Subunit p19; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptor, Interferon alpha-beta; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Skin; Tumor Necrosis Factor-alpha

2015
Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Interleukins; Male; Mice; Psoriasis; Resveratrol; Signal Transduction; Stilbenes

2015
Probing the effects of fish oil on the delivery and inflammation-inducing potential of imiquimod.
    International journal of pharmaceutics, 2015, Jul-25, Volume: 490, Issue:1-2

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Delayed-Action Preparations; Female; Fish Oils; Imiquimod; Inflammation; Mice; Permeability; Psoriasis; Skin; Skin Absorption

2015
Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants.
    Protoplasma, 2016, Volume: 253, Issue:2

    Topics: Aloe; Aminoquinolines; Animals; Celastrus; Curcuma; Cytokines; Dermatitis, Contact; Drug Evaluation, Preclinical; Gene Expression; Imiquimod; Male; Mice; Plant Extracts; Plant Stems; Plants, Medicinal; Psoriasis; Skin; Tinospora

2016
Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Aminoquinolines; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Proliferation; Cells, Cultured; Dermatitis; Disease Models, Animal; DNA-Binding Proteins; Down-Regulation; Humans; Imiquimod; Keratinocytes; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Psoriasis; RNA Interference; Severity of Illness Index; Signal Transduction; Skin

2015
GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation.
    Journal of autoimmunity, 2015, Volume: 61

    Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells; Dermatitis; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression; Humans; Imiquimod; Interleukin-17; Interleukin-6; Lipopolysaccharides; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Reverse Transcriptase Polymerase Chain Reaction; Th17 Cells; Transcription Factors

2015
CCN1, a Pro-Inflammatory Factor, Aggravates Psoriasis Skin Lesions by Promoting Keratinocyte Activation.
    The Journal of investigative dermatology, 2015, Volume: 135, Issue:11

    Topics: Aminoquinolines; Animals; Biopsy, Needle; Cell Proliferation; Cells, Cultured; Cysteine-Rich Protein 61; Disease Models, Animal; Disease Progression; Extracellular Matrix; Female; Humans; Imiquimod; Immunohistochemistry; Inflammation Mediators; Interleukin-23; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Knockout; Psoriasis; Random Allocation; Signal Transduction

2015
Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis.
    Experimental dermatology, 2015, Volume: 24, Issue:11

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Kallikreins; Mice, Knockout; Psoriasis

2015
Decreased Expression of Caveolin-1 Contributes to the Pathogenesis of Psoriasiform Dermatitis in Mice.
    The Journal of investigative dermatology, 2015, Volume: 135, Issue:11

    Topics: Aminoquinolines; Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Blotting, Western; Caveolin 1; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Humans; Imiquimod; Immunohistochemistry; Keratinocytes; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Psoriasis; Random Allocation; Sampling Studies; Signal Transduction; STAT3 Transcription Factor

2015
Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.
    Pharmacological research, 2015, Volume: 99

    Topics: Aminoquinolines; Animals; Azepines; Disease Models, Animal; Imiquimod; Inflammation; Interleukin-17; Interleukin-22; Interleukins; Male; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Signal Transduction; Skin; Triazoles

2015
Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells.
    Nature communications, 2015, Jul-15, Volume: 6

    Topics: Adiponectin; Adjuvants, Immunologic; Adult; Aminoquinolines; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dermatitis; Female; Humans; Imiquimod; Immunoblotting; Interleukin-17; Interleukin-23; Male; Mice; Middle Aged; Psoriasis; Real-Time Polymerase Chain Reaction; Receptors, Adiponectin; Receptors, Antigen, T-Cell, gamma-delta; Reverse Transcriptase Polymerase Chain Reaction; Skin; Subcutaneous Fat

2015
Suppressive effect of β, β-dimethylacryloyl alkannin on activated dendritic cells in an imiquimod-induced psoriasis mouse model.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:6

    Topics: Aminoquinolines; Animals; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokines; Dendritic Cells; Dermatologic Agents; Disease Models, Animal; Humans; Imiquimod; Inflammation Mediators; Lymphocyte Activation; Lymphocytes; Male; Mice, Inbred BALB C; Naphthoquinones; Psoriasis; Severity of Illness Index; Skin; Time Factors

2015
Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice.
    The Journal of investigative dermatology, 2015, Volume: 135, Issue:12

    Topics: Aminoquinolines; Animals; Circadian Rhythm; CLOCK Proteins; Dermatitis; Female; Imiquimod; Interleukin-23; Mice; Mice, Inbred C57BL; Mutation; Period Circadian Proteins; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes

2015
Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Aminolevulinic Acid; Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Imiquimod; Mice; Psoriasis; Skin; Skin Absorption; Tacrolimus; Tretinoin

2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
    Nature communications, 2015, Sep-29, Volume: 6

    Topics: Aminoquinolines; Animals; Animals, Newborn; Anti-Bacterial Agents; Disease Susceptibility; Drug Interactions; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Mice; Mice, Inbred C57BL; Microbiota; Polymyxin B; Psoriasis; Skin; T-Lymphocytes; Vancomycin

2015
IκBζ is a key driver in the development of psoriasis.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Oct-27, Volume: 112, Issue:43

    Topics: Aminoquinolines; Animals; Humans; I-kappa B Proteins; Imiquimod; Mice; Psoriasis

2015
Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase on Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice.
    Antioxidants & redox signaling, 2016, Feb-10, Volume: 24, Issue:5

    Topics: Aminoquinolines; Animals; Cytokines; Dendritic Cells; Disease Models, Animal; Gene Expression; Humans; Hyperplasia; Imiquimod; Inflammation Mediators; Janus Kinases; Lymph Nodes; Lymphocyte Activation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mitogen-Activated Protein Kinases; Mucolipidoses; Neutrophil Infiltration; NF-kappa B; Psoriasis; Reactive Oxygen Species; Severity of Illness Index; Signal Transduction; Skin; Spleen; STAT Transcription Factors; Superoxide Dismutase; T-Lymphocytes; Toll-Like Receptor 7; Transduction, Genetic

2016
Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Nov-15, Volume: 195, Issue:10

    Topics: Aminoquinolines; Animals; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Macrophages; Mice; Mice, Transgenic; Psoriasis; Skin; Transcriptome

2015
IL-22/STAT3-Induced Increases in SLURP1 Expression within Psoriatic Lesions Exerts Antimicrobial Effects against Staphylococcus aureus.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Aminoquinolines; Animals; Antigens, Ly; Female; Homeostasis; Humans; Imiquimod; Interleukin-22; Interleukins; Keratinocytes; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Staphylococcus aureus; STAT3 Transcription Factor; Up-Regulation; Urokinase-Type Plasminogen Activator

2015
Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation.
    The American journal of Chinese medicine, 2015, Volume: 43, Issue:7

    Topics: Administration, Oral; Aminoquinolines; Animals; Anti-Inflammatory Agents; Antrodia; Autoimmunity; Cell Differentiation; Cells, Cultured; Depression, Chemical; Disease Models, Animal; Drugs, Chinese Herbal; Imiquimod; Interleukin-17; Male; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Phosphorylation; Phytotherapy; Psoriasis; Skin; STAT3 Transcription Factor; Th17 Cells

2015
Percutaneous delivery of α-melanocyte-stimulating hormone for the treatment of imiquimod-induced psoriasis.
    Journal of drug targeting, 2016, Volume: 24, Issue:6

    Topics: Administration, Cutaneous; alpha-MSH; Aminoquinolines; Animals; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Ethylene Glycols; Gels; Imiquimod; Inflammation; Male; Mice; Mice, Inbred C57BL; Microdialysis; Psoriasis; Rats; Rats, Sprague-Dawley; Skin Absorption

2016
Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice.
    The British journal of dermatology, 2016, Volume: 174, Issue:5

    Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aminoquinolines; Animals; Biomarkers; Calgranulin A; Drug Eruptions; Imiquimod; Interleukins; Intracellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Mice, Knockout; Ointments; Protein Serine-Threonine Kinases; Psoriasis; RNA, Messenger; Tumor Necrosis Factor-alpha

2016
Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis.
    Science translational medicine, 2015, Dec-16, Volume: 7, Issue:318

    Topics: Aminoquinolines; Animals; Cell Transplantation; CHO Cells; Cricetulus; Disease Models, Animal; Female; Gene Expression Regulation; Genetic Engineering; Genetic Therapy; HEK293 Cells; HeLa Cells; Humans; Imiquimod; Inflammation Mediators; Interleukin-10; Interleukin-22; Interleukin-4; Interleukins; Logic; Mice, Inbred C57BL; Psoriasis; Reproducibility of Results; Signal Transduction; Skin; Time Factors; Transfection; Tumor Necrosis Factor-alpha

2015
IMQ Induced K14-VEGF Mouse: A Stable and Long-Term Mouse Model of Psoriasis-Like Inflammation.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Drug Eruptions; Imiquimod; Mice, Inbred Strains; Mice, Transgenic; Otitis; Psoriasis; Vascular Endothelial Growth Factor A

2015
Distinct expression of interleukin (IL)-36α, β and γ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease.
    Clinical and experimental immunology, 2016, Volume: 184, Issue:2

    Topics: Aminoquinolines; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Caco-2 Cells; Cell Line; Crohn Disease; Dendritic Cells; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Imiquimod; Inflammation; Interleukin-1; Interleukins; Intestinal Mucosa; Keratinocytes; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Plasma Cells; Psoriasis; RNA, Messenger; Skin; Synovial Membrane; Th17 Cells

2016
Lipocalin-2 exacerbates psoriasiform skin inflammation by augmenting T-helper 17 response.
    The Journal of dermatology, 2016, Volume: 43, Issue:7

    Topics: Aminoquinolines; Animals; Antimicrobial Cationic Peptides; beta-Defensins; Cells, Cultured; Chemokine CCL20; Female; Humans; Imiquimod; Keratinocytes; Lipocalin-2; Mice, Inbred BALB C; Psoriasis; Skin; Th1 Cells; Th17 Cells

2016
Imiquimod Increases Cutaneous VEGF Expression in Imiquimod-induced Psoriatic Mouse Model.
    Current vascular pharmacology, 2016, Volume: 14, Issue:3

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Psoriasis; Skin; Vascular Endothelial Growth Factor A

2016
Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion.
    European journal of pharmacology, 2016, Feb-05, Volume: 772

    Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cytokines; Gene Expression Regulation; Glucosides; Imiquimod; Keratinocytes; Mice; Monoterpenes; Nuclear Receptor Subfamily 1, Group F, Member 3; Phosphorylation; Psoriasis; RNA, Messenger; Skin; STAT3 Transcription Factor; Th17 Cells

2016
Immunosuppressive effect of adipose-derived stromal cells on imiquimod-induced psoriasis in mice.
    Journal of dermatological science, 2016, Volume: 82, Issue:1

    Topics: Adipose Tissue; Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Immune Tolerance; Inflammation Mediators; Mice; Psoriasis; Signal Transduction; Skin; Stromal Cells; Time Factors

2016
Trem-1 is not crucial in psoriasiform imiquimod-induced skin inflammation in mice.
    Experimental dermatology, 2016, Volume: 25, Issue:5

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Imiquimod; Male; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Triggering Receptor Expressed on Myeloid Cells-1

2016
Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway.
    International immunopharmacology, 2016, Volume: 32

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cell Proliferation; Flavonols; Imiquimod; Immunologic Factors; Interleukin-17; Janus Kinase 3; Keratinocytes; Male; Mice, Inbred BALB C; Psoriasis; Signal Transduction; Skin; STAT3 Transcription Factor; Th17 Cells

2016
Topical imiquimod yields systemic effects due to unintended oral uptake.
    Scientific reports, 2016, Jan-28, Volume: 6

    Topics: Administration, Oral; Administration, Topical; Aminoquinolines; Animals; Disease Models, Animal; Gastrointestinal Tract; Imiquimod; Interferon Type I; Mice; Phenotype; Psoriasis; Skin Diseases

2016
Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells.
    The Journal of allergy and clinical immunology, 2016, Volume: 137, Issue:5

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; B7-H1 Antigen; Humans; Imiquimod; Inflammation; Interleukin-17; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Psoriasis; Recombinant Proteins; Skin; T-Lymphocyte Subsets

2016
Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in Human Psoriasis and Imiquimod-induced Murine Psoriasiform Dermatitis Model.
    Acta dermato-venereologica, 2016, 08-23, Volume: 96, Issue:6

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Fatty Acid-Binding Proteins; Imiquimod; Male; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Psoriasis; TOR Serine-Threonine Kinases; Up-Regulation

2016
Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models.
    Biochemical pharmacology, 2016, Apr-01, Volume: 105

    Topics: Aminoquinolines; Animals; Cell Death; Cell Line; Cell Survival; Digitoxigenin; Disease Models, Animal; Female; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Necrosis; Oxidative Stress; Psoriasis; Tetradecanoylphorbol Acetate

2016
Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice'.
    The British journal of dermatology, 2016, Volume: 174, Issue:6

    Topics: Aminoquinolines; Animals; Imiquimod; Inflammation; Mice; Psoriasis; Tumor Necrosis Factor-alpha

2016
Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Drug Evaluation, Preclinical; Female; Gene Expression; Genes, Reporter; Humans; Imiquimod; Immunologic Factors; Interleukin-17; Jurkat Cells; Luciferases; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Permeability; Primary Cell Culture; Psoriasis; Skin; Small Molecule Libraries; Th17 Cells; Translational Research, Biomedical

2016
Oral administration of acarbose ameliorates imiquimod-induced psoriasis-like dermatitis in a mouse model.
    International immunopharmacology, 2016, Volume: 33

    Topics: Acarbose; Administration, Oral; Aminoquinolines; Animals; Cell Movement; Cytokines; Dermatitis, Contact; Disease Models, Animal; Humans; Imiquimod; Mice; Mice, Inbred BALB C; Neutrophils; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; T-Lymphocytes, Regulatory; Th17 Cells

2016
Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling.
    Scientific reports, 2016, Feb-19, Volume: 6

    Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Cytokines; Disease Models, Animal; Enzyme Activation; Epidermal Cells; Epidermis; Female; Gene Expression; Gene Expression Regulation; Heme Oxygenase-1; Imiquimod; Keratinocytes; Mice; Models, Biological; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Psoriasis; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Th17 Cells

2016
Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine.
    Scandinavian journal of immunology, 2016, Volume: 83, Issue:6

    Topics: Aminoquinolines; Animals; Cell Movement; Cytokines; Disease Models, Animal; Female; Forkhead Transcription Factors; Humans; Imiquimod; Inflammation; Interleukin-2 Receptor alpha Subunit; Methylhistamines; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Skin; T-Lymphocytes, Regulatory; Th1 Cells

2016
Therapeutic Effects of Erythroid Differentiation Regulator 1 on Imiquimod-Induced Psoriasis-Like Skin Inflammation.
    International journal of molecular sciences, 2016, Feb-17, Volume: 17, Issue:2

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Calgranulin A; Disease Models, Animal; Gene Expression Regulation; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Membrane Proteins; Mice; Psoriasis; Recombinant Proteins; Th17 Cells; Tumor Suppressor Proteins

2016
CX3CR1 deficiency attenuates imiquimod-induced psoriasis-like skin inflammation with decreased M1 macrophages.
    Journal of dermatological science, 2016, Volume: 82, Issue:3

    Topics: Aminoquinolines; Animals; Cell Count; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Interleukins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Chemokine; Skin; Tumor Necrosis Factor-alpha

2016
Increased Lipocalin-2 Contributes to the Pathogenesis of Psoriasis by Modulating Neutrophil Chemotaxis and Cytokine Secretion.
    The Journal of investigative dermatology, 2016, Volume: 136, Issue:7

    Topics: Adolescent; Adult; Aminoquinolines; Animals; Antibodies, Monoclonal; Biopsy; Cell Differentiation; Chemotaxis; Cytokines; Epidermis; Female; HL-60 Cells; Humans; Imiquimod; Inflammation; Lipocalin-2; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Middle Aged; Neutrophils; Psoriasis; Recombinant Proteins; RNA, Small Interfering; Young Adult

2016
IL-6 Signaling in Myelomonocytic Cells Is Not Crucial for the Development of IMQ-Induced Psoriasis.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Aminoquinolines; Animals; Bone Marrow; Cell Compartmentation; Gene Deletion; Humans; Imiquimod; Interleukin-6; Mice; Monocytes; Psoriasis; Receptors, Interleukin-6; Signal Transduction; Spleen; T-Lymphocytes

2016
AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model.
    European journal of immunology, 2016, Volume: 46, Issue:6

    Topics: Aminoquinolines; Animals; Cell Proliferation; Chemotaxis; Disease Models, Animal; Imiquimod; Immunity, Innate; Interleukin-22; Interleukins; Mice; Mice, Knockout; Psoriasis; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Aryl Hydrocarbon; T-Lymphocyte Subsets; Th17 Cells

2016
Comment on 'Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice': reply from authors.
    The British journal of dermatology, 2016, Volume: 174, Issue:6

    Topics: Aminoquinolines; Animals; Imiquimod; Inflammation; Mice; Psoriasis; Tumor Necrosis Factor-alpha

2016
Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation.
    European journal of immunology, 2016, Volume: 46, Issue:7

    Topics: Aminoquinolines; Animals; Biomarkers; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Epidermis; Filaggrin Proteins; Gene Expression; Gene Expression Regulation; Imiquimod; Keratinocytes; Male; Mice; Mice, Knockout; Oncostatin M; Phenotype; Psoriasis; Skin

2016
Vascular endothelial growth factor partially induces pruritus via epidermal hyperinnervation in imiquimod-induced psoriasiform dermatitis in mice.
    Journal of dermatological science, 2016, Volume: 83, Issue:2

    Topics: Aminoquinolines; Animals; Axitinib; Dermatitis, Atopic; Disease Models, Animal; Epidermis; Humans; Imidazoles; Imiquimod; Indazoles; Mice; Pruritus; Psoriasis; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A

2016
MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A.
    The Journal of investigative dermatology, 2016, Volume: 136, Issue:8

    Topics: Aminoquinolines; Animals; Antigens, Differentiation, T-Lymphocyte; Biopsy; Coculture Techniques; Epidermis; Gene Silencing; Humans; Imiquimod; Inflammation; Interleukin-17; Keratinocytes; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Phosphorylation; Psoriasis; Receptors, Interleukin-17; Ribonucleases; Skin; STAT3 Transcription Factor; Transcription Factors; Tumor Necrosis Factor-alpha

2016
Original Research: Different imiquimod creams resulting in differential effects for imiquimod-induced psoriatic mouse models.
    Experimental biology and medicine (Maywood, N.J.), 2016, Volume: 241, Issue:16

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Dermatologic Agents; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Skin Cream; Treatment Outcome

2016
Influence of different types of contact hypersensitivity on imiquimod-induced psoriasis-like inflammation in mice.
    Molecular medicine reports, 2016, Volume: 14, Issue:1

    Topics: Aminoquinolines; Animals; Biomarkers; Cytokines; Dermatitis, Contact; Disease Models, Animal; Female; Gene Expression; Imiquimod; Mice; Psoriasis; Skin; Th1 Cells; Th17 Cells; Th2 Cells

2016
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
    Nature communications, 2016, 05-25, Volume: 7

    Topics: Aminoquinolines; Animals; B-Lymphocytes; Disease Models, Animal; Imiquimod; Interleukin-10; Mice; Mice, Inbred C57BL; NFATC Transcription Factors; Psoriasis; Signal Transduction

2016
Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88.
    Biochemical pharmacology, 2016, 09-01, Volume: 115

    Topics: Aminoquinolines; Andrographis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Diterpenes; Drugs, Chinese Herbal; Imiquimod; Interleukin-1beta; Interleukin-23; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Proteolysis; Psoriasis; Skin; TNF Receptor-Associated Factor 6

2016
The genetic difference between C57Bl/6J and C57Bl/6N mice significantly impacts Aldara™-induced psoriasiform dermatitis.
    Experimental dermatology, 2017, Volume: 26, Issue:4

    Topics: Aminoquinolines; Animals; Dermatitis; Disease Models, Animal; Imiquimod; Mice, Inbred C57BL; Psoriasis; Skin; Species Specificity

2017
Collagen-induced arthritis and imiquimod-induced psoriasis develop independently of interleukin-33.
    Arthritis research & therapy, 2016, 06-18, Volume: 18, Issue:1

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Resorption; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Imiquimod; Interleukin-33; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis

2016
Paeoniflorin suppresses inflammatory response in imiquimod-induced psoriasis-like mice and peripheral blood mononuclear cells (PBMCs) from psoriasis patients.
    Canadian journal of physiology and pharmacology, 2016, Volume: 94, Issue:8

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Glucosides; Humans; Imiquimod; Inflammation Mediators; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred BALB C; Monoterpenes; Psoriasis; Random Allocation

2016
The Exonuclease Trex2 Shapes Psoriatic Phenotype.
    The Journal of investigative dermatology, 2016, Volume: 136, Issue:12

    Topics: Aminoquinolines; Animals; Apoptosis; Biopsy, Needle; Case-Control Studies; Cell Survival; Cells, Cultured; Disease Models, Animal; Exodeoxyribonucleases; Gene Expression Regulation; Humans; Imiquimod; Immunohistochemistry; Keratinocytes; Mice; Mice, Knockout; Phenotype; Prognosis; Psoriasis; Severity of Illness Index; Up-Regulation

2016
Reducing Flightless I expression decreases severity of psoriasis in an imiquimod-induced murine model of psoriasiform dermatitis.
    The British journal of dermatology, 2017, Volume: 176, Issue:3

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Carrier Proteins; Cytoskeletal Proteins; Dermatitis; Disease Models, Animal; Drug Eruptions; Female; Humans; Imiquimod; Irritants; Male; Mice, Inbred BALB C; Microfilament Proteins; Middle Aged; Psoriasis; RNA, Messenger; Toll-Like Receptor 4; Trans-Activators

2017
Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression.
    The Journal of investigative dermatology, 2016, Volume: 136, Issue:11

    Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Cell Cycle; Cell Proliferation; Disease Models, Animal; Hair Follicle; Imiquimod; Mice; Mice, Inbred C57BL; Psoriasis; Stem Cells

2016
Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.
    Antioxidants & redox signaling, 2017, 01-10, Volume: 26, Issue:2

    Topics: Administration, Topical; Aminoquinolines; Animals; Anthocyanins; Antioxidants; Binding Sites; Biopsy; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Imiquimod; Immunomodulation; Inflammation Mediators; Mice; Models, Molecular; Molecular Conformation; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Psoriasis; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Skin; TOR Serine-Threonine Kinases

2017
Multi-glycoside of Tripterygium wilfordii Hook. f. ameliorates imiquimod-induced skin lesions through a STAT3-dependent mechanism involving the inhibition of Th17-mediated inflammatory responses.
    International journal of molecular medicine, 2016, Volume: 38, Issue:3

    Topics: Aminoquinolines; Animals; CD4-Positive T-Lymphocytes; Cytokines; Gene Expression; Glycosides; Imiquimod; Immunohistochemistry; Inflammation; Inflammation Mediators; Interleukin-17; Mice, Inbred BALB C; Phosphorylation; Phytotherapy; Protective Agents; Psoriasis; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Diseases; STAT3 Transcription Factor; T-Lymphocytes, Regulatory; Th17 Cells; Tripterygium

2016
Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Actinobacteria; Aminoquinolines; Animals; Anti-Bacterial Agents; Clostridiales; Disease Models, Animal; Female; Gastrointestinal Microbiome; Gene Expression; Germ-Free Life; Humans; Imiquimod; Interleukin-17; Lactobacillales; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; Species Specificity; Th17 Cells

2016
Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod-induced psoriasis-like skin inflammation in mice.
    Journal of dermatological science, 2016, Volume: 84, Issue:1

    Topics: Aminoquinolines; Animals; Anti-Bacterial Agents; Azithromycin; Cell Proliferation; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Humans; Imiquimod; Keratinocytes; Leukocytes, Mononuclear; Lysosomes; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Psoriasis; Signal Transduction; Skin; Spleen; Th17 Cells; Toll-Like Receptor 7

2016
Increased βTrCP are associated with imiquimod-induced psoriasis-like skin inflammation in mice via NF-κB signaling pathway.
    Gene, 2016, Oct-30, Volume: 592, Issue:1

    Topics: Aminoquinolines; Animals; beta-Transducin Repeat-Containing Proteins; Cell Line; Cells, Cultured; Humans; Imiquimod; Intercellular Adhesion Molecule-1; Keratinocytes; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Psoriasis; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation

2016
Leptin deficiency in mice counteracts imiquimod (IMQ)-induced psoriasis-like skin inflammation while leptin stimulation induces inflammation in human keratinocytes.
    Experimental dermatology, 2017, Volume: 26, Issue:4

    Topics: Aminoquinolines; Animals; Cell Proliferation; Cells, Cultured; Chemokine CCL20; Chemokine CXCL1; Gene Expression; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukin-6; Interleukins; Keratinocytes; Leptin; Male; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Psoriasis; RNA, Messenger

2017
Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model.
    Cell death & disease, 2016, 08-18, Volume: 7, Issue:8

    Topics: Acanthosis Nigricans; Aminoquinolines; Animals; Cell Differentiation; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Glucosides; Humans; Imiquimod; Immunohistochemistry; Inflammation; Interleukin-22; Interleukins; Keratinocytes; Lipids; Luteolin; Mice, Inbred C57BL; Oxidation-Reduction; Phenotype; Protein Transport; Psoriasis; Signal Transduction; STAT3 Transcription Factor

2016
MAD ointment ameliorates Imiquimod-induced psoriasiform dermatitis by inhibiting the IL-23/IL-17 axis in mice.
    International immunopharmacology, 2016, Volume: 39

    Topics: Aminoquinolines; Animals; Cell Proliferation; Centella; Dermatitis; Disease Models, Animal; Female; Humans; Imiquimod; Interleukin-17; Interleukin-23; Mice; Mice, Inbred BALB C; Ointments; Psoriasis; Signal Transduction; Skin; Th17 Cells; Triterpenes

2016
MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis.
    The Journal of allergy and clinical immunology, 2017, Volume: 139, Issue:2

    Topics: Adult; Aminoquinolines; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Imiquimod; Interleukin-17; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Neutrophil Infiltration; Polymorphism, Single Nucleotide; Psoriasis; Skin; Sweden

2017
Spread of Psoriasiform Inflammation to Remote Tissues Is Restricted by the Atypical Chemokine Receptor ACKR2.
    The Journal of investigative dermatology, 2017, Volume: 137, Issue:1

    Topics: Aminoquinolines; Animals; Biopsy, Needle; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Humans; Imiquimod; Immunohistochemistry; Inflammation; Keratinocytes; Mice; Mice, Inbred C57BL; Phenotype; Polymerase Chain Reaction; Psoriasis; Random Allocation; Receptors, Chemokine; Reference Values; Statistics, Nonparametric; Up-Regulation

2017
miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice.
    Experimental dermatology, 2017, Volume: 26, Issue:1

    Topics: Aminoquinolines; Animals; Down-Regulation; Imiquimod; Keratinocytes; Mice; Mice, Knockout; MicroRNAs; Psoriasis; T-Lymphocytes; Up-Regulation

2017
Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.
    BMC complementary and alternative medicine, 2016, Aug-31, Volume: 16, Issue:1

    Topics: Aminoquinolines; Animals; Antioxidants; Body Weight; Catechin; Cytokines; Imiquimod; Inflammation; Mice; Mice, Inbred BALB C; Psoriasis; Skin; Spleen

2016
A PPARδ-selective antagonist ameliorates IMQ-induced psoriasis-like inflammation in mice.
    International immunopharmacology, 2016, Volume: 40

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Benzamides; Cytokines; Imiquimod; Mice; PPAR delta; Psoriasis; RNA, Messenger; Skin; Sulfones

2016
Protective effects of agonistic anti-4-1BB antibody on the development of imiquimod-induced psoriasis-like dermatitis in mice.
    Immunology letters, 2016, Volume: 178

    Topics: Aminoquinolines; Animals; Antibodies, Monoclonal; Biopsy; Cytokines; Disease Models, Animal; Female; Imiquimod; Inflammation Mediators; Mice; Phenotype; Protective Agents; Psoriasis; Skin; Splenomegaly; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Necrosis Factor Receptor Superfamily, Member 9

2016
Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism.
    Experimental dermatology, 2017, Volume: 26, Issue:3

    Topics: Aminoquinolines; Animals; Dermatitis; Epidermis; Imiquimod; Kallikreins; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptor, PAR-2

2017
Improved topical delivery of tacrolimus: A novel composite hydrogel formulation for the treatment of psoriasis.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, 11-28, Volume: 242

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Biological Availability; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Hydrogels; Imiquimod; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Polymers; Psoriasis; Skin; Skin Absorption; Solubility; Tacrolimus

2016
Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 10-11, Volume: 113, Issue:41

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Disease Susceptibility; DNA-Binding Proteins; Female; Gene Expression Profiling; Imiquimod; Interleukin-17; Interleukin-23; Keratinocytes; Lymphocytes; Male; Mice; Mice, Knockout; Psoriasis; Transcriptome

2016
IL-22 binding protein regulates murine skin inflammation.
    Experimental dermatology, 2017, Volume: 26, Issue:5

    Topics: Aminoquinolines; Animals; Case-Control Studies; Dermatitis, Contact; Female; Humans; Imiquimod; Male; Mice; Oxazolone; Psoriasis; Receptors, Interleukin

2017
Tacrolimus and curcumin co-loaded liposphere gel: Synergistic combination towards management of psoriasis.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, 12-10, Volume: 243

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Chemistry, Pharmaceutical; Curcumin; Delayed-Action Preparations; Dermatologic Agents; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Gels; Imiquimod; Immunosuppressive Agents; Lipids; Male; Mice; Mice, Inbred BALB C; Particle Size; Psoriasis; Tacrolimus; Tissue Distribution

2016
Proinflammatory effect of high-mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development.
    The Journal of pathology, 2017, Volume: 241, Issue:3

    Topics: Aminoquinolines; Animals; Autocrine Communication; Cell Proliferation; Disease Models, Animal; HMGB1 Protein; Humans; Imiquimod; Inflammasomes; Interleukin-17; Interleukin-18; Keratinocytes; Mice, Inbred BALB C; Psoriasis; Signal Transduction

2017
IL-12 protects from psoriasiform skin inflammation.
    Nature communications, 2016, 11-28, Volume: 7

    Topics: Aminoquinolines; Animals; Female; Humans; Imiquimod; Inflammation; Interleukin-12; Interleukin-23; Keratinocytes; Mice, Inbred C57BL; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin

2016
Polyinosinic-polycytidylic acid (poly(I:C)) attenuates imiquimod-induced skin inflammation in mice by increasing cutaneous PD-L1 expression.
    Experimental dermatology, 2017, Volume: 26, Issue:4

    Topics: Aminoquinolines; Animals; B7-H1 Antigen; Cell Line, Transformed; Dermatitis; Disease Models, Animal; Humans; Imiquimod; Keratinocytes; Mice; Poly I-C; Psoriasis; Toll-Like Receptor 3

2017
Overexpression of Glucocorticoid-induced Leucine Zipper (GILZ) increases susceptibility to Imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1.
    Scientific reports, 2016, 12-09, Volume: 6

    Topics: Aminoquinolines; Animals; Calgranulin A; Cytokines; Dendritic Cells; Gene Expression Regulation; Gene Knock-In Techniques; Imiquimod; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Neutrophils; Psoriasis; Recombinant Proteins; Signal Transduction; Skin; Smad2 Protein; Smad3 Protein; Specific Pathogen-Free Organisms; T-Lymphocytes; Transcription Factors; Transforming Growth Factor beta1

2016
Decreased expression of IL-27 in moderate-to-severe psoriasis and its anti-inflammation role in imiquimod-induced psoriasis-like mouse model.
    Journal of dermatological science, 2017, Volume: 85, Issue:2

    Topics: Aminoquinolines; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Imiquimod; Immunotherapy; Injections, Subcutaneous; Interferon-gamma; Interleukin-10; Interleukin-17; Interleukins; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Psoriasis; Receptors, Interleukin; Recombinant Proteins; RNA, Messenger; Severity of Illness Index; Skin; Th1 Cells; Th17 Cells

2017
Involvement of high mobility group box-1 in imiquimod-induced psoriasis-like mice model.
    The Journal of dermatology, 2017, Volume: 44, Issue:5

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Glycyrrhizic Acid; HMGB1 Protein; Imiquimod; Phytotherapy; Plant Extracts; Psoriasis

2017
TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model.
    Experimental dermatology, 2017, Volume: 26, Issue:8

    Topics: Aminoquinolines; Animals; Antineoplastic Agents; Disease Models, Animal; Humans; Imiquimod; Mice, Knockout; Psoriasis; Ribonucleoproteins

2017
The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal.
    The Journal of investigative dermatology, 2017, Volume: 137, Issue:3

    Topics: Aminoquinolines; Animals; Dermatitis; Dermatology; Disease Models, Animal; Humans; Imiquimod; Inflammation; Mice; Psoriasis; Research Design

2017
Activation of Langerhans cells promotes the inflammation in imiquimod-induced psoriasis-like dermatitis.
    Journal of dermatological science, 2017, Volume: 85, Issue:3

    Topics: Aminoquinolines; Animals; Antigens, CD; Antigens, Surface; Cytokines; Disease Models, Animal; Epidermal Cells; Epidermis; Flow Cytometry; Imiquimod; Langerhans Cells; Lectins, C-Type; Lymph Nodes; Mannose-Binding Lectins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Psoriasis; Tumor Necrosis Factor-alpha

2017
Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.
    Nature communications, 2016, 12-16, Volume: 7

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Dendritic Cells; Drug Eruptions; Gene Expression Regulation; Humans; Imiquimod; Inflammation; Interleukin-23; Langerhans Cells; Major Histocompatibility Complex; Membrane Proteins; Mice; Mice, Knockout; Monocytes; Psoriasis; Skin

2016
Anti-psoriatic potential of Solanum xanthocarpum stem in Imiquimod-induced psoriatic mice model.
    Journal of ethnopharmacology, 2017, Feb-23, Volume: 198

    Topics: Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Female; Imiquimod; Male; Mice; Plant Extracts; Plant Stems; Psoriasis; Solanum

2017
Imiquimod Treatment Causes Systemic Disease in Mice Resembling Generalized Pustular Psoriasis in an IL-1 and IL-36 Dependent Manner.
    Mediators of inflammation, 2016, Volume: 2016

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Body Temperature; Disease Models, Animal; Female; Imiquimod; Inflammation; Interleukin-1; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Pain Measurement; Psoriasis; Receptors, Interleukin-1 Type I; Sex Factors; Skin

2016
Surgical Denervation in the Imiquimod-Induced Psoriasiform Mouse Model.
    Methods in molecular biology (Clifton, N.J.), 2017, Volume: 1559

    Topics: Aminoquinolines; Animals; Denervation; Dermatologic Surgical Procedures; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Imiquimod; Interleukin-17; Interleukin-23; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; T-Lymphocytes; Toll-Like Receptor 7

2017
Isogarcinol Extracted from Garcinia mangostana L. Ameliorates Imiquimod-Induced Psoriasis-like Skin Lesions in Mice.
    Journal of agricultural and food chemistry, 2017, Feb-01, Volume: 65, Issue:4

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Female; Garcinia mangostana; Humans; Imiquimod; Interleukin-2; Interleukin-23; Mice; Mice, Inbred C57BL; Plant Extracts; Psoriasis; Skin; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Necrosis Factor-alpha

2017
BAY 11-7082 inhibits the NF-κB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis.
    Clinical science (London, England : 1979), 2017, Mar-01, Volume: 131, Issue:6

    Topics: Aminoquinolines; Animals; Apoptosis; Cytokines; Dermatologic Agents; Drug Eruptions; Drug Evaluation, Preclinical; Imiquimod; Inflammasomes; Male; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nitriles; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; RNA, Messenger; STAT3 Transcription Factor; Sulfones

2017
Tonsil-derived mesenchymal stem cells (T-MSCs) prevent Th17-mediated autoimmune response via regulation of the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway.
    Journal of tissue engineering and regenerative medicine, 2018, Volume: 12, Issue:2

    Topics: Animals; Autoimmunity; B7-H1 Antigen; Cell Differentiation; Culture Media, Conditioned; Female; Gene Expression Regulation; Imiquimod; Inflammation; Interleukin-17; Lymph Nodes; Mesenchymal Stem Cells; Mice, Inbred C57BL; Palatine Tonsil; Psoriasis; Side-Population Cells; Signal Transduction; Skin; Th17 Cells

2018
Ccr6 Is Dispensable for the Development of Skin Lesions Induced by Imiquimod despite its Effect on Epidermal Homing of IL-22-Producing Cells.
    The Journal of investigative dermatology, 2017, Volume: 137, Issue:5

    Topics: Aminoquinolines; Animals; beta-Galactosidase; Cells, Cultured; Disease Models, Animal; Epidermis; Gene Knock-In Techniques; Homeodomain Proteins; Imiquimod; Interleukin-22; Interleukins; Mice; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, CCR6; T-Lymphocyte Subsets

2017
GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model.
    Cellular signalling, 2017, Volume: 33

    Topics: Acetamides; Acetates; Aminoquinolines; Animals; Disease Models, Animal; Dual Oxidases; Epidermis; Imiquimod; Inflammation; Interleukin-6; Male; Mice, Inbred BALB C; Models, Biological; Psoriasis; Receptors, G-Protein-Coupled; Signal Transduction; Th17 Cells; Up-Regulation

2017
Effects of Topical Application of Betamethasone on Imiquimod-induced Psoriasis-like Skin Inflammation in Mice.
    The Kobe journal of medical sciences, 2016, Sep-09, Volume: 62, Issue:4

    Topics: Administration, Topical; Aminoquinolines; Animals; Anti-Inflammatory Agents; Betamethasone; Cytokines; Disease Models, Animal; Female; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Psoriasis; RNA, Messenger; Skin; Th1 Cells; Th17 Cells

2016
Psoriasis-like inflammation leads to renal dysfunction via upregulation of NADPH oxidases and inducible nitric oxide synthase.
    International immunopharmacology, 2017, Volume: 46

    Topics: Acetylcysteine; Aminoquinolines; Animals; Antioxidants; Buthionine Sulfoximine; Disease Models, Animal; Humans; Imiquimod; Inflammation; Kidney; Kidney Diseases; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; Nitric Oxide Synthase Type II; Oxidative Stress; Psoriasis

2017
Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis.
    Genome medicine, 2017, 03-09, Volume: 9, Issue:1

    Topics: Aminoquinolines; Animals; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Imiquimod; Interleukin-17; Male; Mice; Mice, Inbred Strains; Psoriasis; Sequence Analysis, RNA; Sex Factors; Skin; Species Specificity

2017
Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.
    Journal of immunology (Baltimore, Md. : 1950), 2009, May-01, Volume: 182, Issue:9

    Topics: Aminoquinolines; Animals; Cell Differentiation; Cell Proliferation; Dermatitis, Contact; Disease Models, Animal; Humans; Imiquimod; Inflammation Mediators; Interleukin-17; Interleukin-23; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Receptors, Interleukin-17

2009
Psoriasis.
    The New England journal of medicine, 2009, Oct-22, Volume: 361, Issue:17

    Topics: Aminoquinolines; Humans; Imiquimod; Interferon Inducers; Psoriasis

2009
Imiquimod cream 5% for the treatment of arsenic-induced cutaneous neoplasms.
    Cutis, 2010, Volume: 85, Issue:4

    Topics: Administration, Cutaneous; Aged, 80 and over; Aminoquinolines; Antineoplastic Agents; Arsenic; Carcinoma, Squamous Cell; Follow-Up Studies; Humans; Imiquimod; Keratosis; Male; Neoplasm Recurrence, Local; Psoriasis; Skin Neoplasms

2010
Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.
    PloS one, 2011, Apr-04, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Aged; Aminoquinolines; Animals; Cytokines; Disease Models, Animal; Epidermis; Gene Expression Profiling; Genomics; Humans; Imiquimod; Keratinocytes; Leukocytes; Mice; Middle Aged; Mitosis; Phenotype; Psoriasis; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Transcription, Genetic; Young Adult

2011
[Oral acitretin and topical imiquimod as neoadjuvant treatment for giant basal cell carcinoma].
    Actas dermo-sifiliograficas, 2012, Volume: 103, Issue:2

    Topics: Acitretin; Administration, Cutaneous; Administration, Oral; Aged; Aminoquinolines; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Basal Cell; Combined Modality Therapy; Facial Neoplasms; Female; Humans; Imiquimod; Neoadjuvant Therapy; Psoriasis; Remission Induction; Skin Neoplasms; Skin Ulcer; Thoracic Neoplasms

2012
Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
    Journal of immunology (Baltimore, Md. : 1950), 2011, Jul-01, Volume: 187, Issue:1

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cell Differentiation; Colitis; Dextran Sulfate; Drug Delivery Systems; Hypersensitivity, Delayed; Imiquimod; Interleukin-12; Interleukin-23; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; TYK2 Kinase

2011
Anti-inflammatory and immunomodulatory effects of bortezomib in various in vivo models.
    Pharmacology, 2011, Volume: 88, Issue:1-2

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Anti-Inflammatory Agents; Boronic Acids; Bortezomib; Dinitrofluorobenzene; Disease Models, Animal; Drug Compounding; Drug Evaluation, Preclinical; Drug Stability; Female; Hypersensitivity, Delayed; Imiquimod; Immunologic Factors; Irritants; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Peritonitis; Psoriasis; Pyrazines; Random Allocation; Temperature; Thioglycolates

2011
Skin permeating nanogel for the cutaneous co-delivery of two anti-inflammatory drugs.
    Biomaterials, 2012, Volume: 33, Issue:5

    Topics: Administration, Cutaneous; Aminoquinolines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Delivery Systems; Humans; Hypromellose Derivatives; Imiquimod; Immunohistochemistry; Inflammation; Methylcellulose; Mice; Mice, Inbred C57BL; Nanogels; Nanoparticles; Particle Size; Permeability; Polyethylene Glycols; Polyethyleneimine; Psoriasis; Rheology; Skin; Surface Properties; Viscosity

2012
IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice.
    Journal of immunology (Baltimore, Md. : 1950), 2012, Jan-01, Volume: 188, Issue:1

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Antigens, Differentiation; Chemokine CCL3; Dermatitis; Disease Models, Animal; Gene Expression Regulation; Imiquimod; Immunity, Innate; Interleukin-22; Interleukins; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; T-Lymphocytes

2012
Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:6

    Topics: Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Animals; Dendritic Cells; Disease Models, Animal; Humans; Imiquimod; Interleukin-17; Interleukin-22; Interleukins; Macrophages; Mice; Mice, Knockout; Neutrophils; Nuclear Receptor Subfamily 1, Group F, Member 3; Psoriasis; Receptors, Antigen, T-Cell, gamma-delta; Skin; T-Lymphocytes

2012
Assessment of an imiquimod-induced psoriatic mouse model in relation to oxidative stress.
    Archives of dermatological research, 2012, Volume: 304, Issue:9

    Topics: Aminoquinolines; Animals; Antioxidants; Disease Models, Animal; Female; Imiquimod; Mice; Mice, Inbred BALB C; Oxidative Stress; Peroxidase; Psoriasis; Reactive Oxygen Species; Skin; Superoxide Dismutase; Superoxide Dismutase-1

2012
An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling.
    The Journal of investigative dermatology, 2013, Volume: 133, Issue:2

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Disease Models, Animal; Female; Imiquimod; Interleukin-17; Interleukin-22; Interleukin-6; Interleukins; Macrophages; Mice; Mice, Knockout; Neutrophil Infiltration; Psoriasis; Receptors, Interleukin-17; Signal Transduction; Skin

2013
IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions.
    The Journal of investigative dermatology, 2013, Volume: 133, Issue:2

    Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cells, Cultured; Chemokines; Dendritic Cells; Disease Models, Animal; Epidermal Cells; Epidermis; Female; Humans; Imiquimod; Interleukin-23 Subunit p19; Interleukins; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Psoriasis; RNA, Messenger; Th1 Cells; Tumor Necrosis Factor-alpha

2013
Caspase-14-deficient mice are more prone to the development of parakeratosis.
    The Journal of investigative dermatology, 2013, Volume: 133, Issue:3

    Topics: Aminoquinolines; Animals; Caspases; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Genetic Predisposition to Disease; Imiquimod; Keratinocytes; Mice; Mice, Knockout; Parakeratosis; Psoriasis

2013
Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis.
    Journal of immunology (Baltimore, Md. : 1950), 2012, Nov-01, Volume: 189, Issue:9

    Topics: Aminoquinolines; Animals; Class I Phosphatidylinositol 3-Kinases; Class Ib Phosphatidylinositol 3-Kinase; Dermatitis; Disease Models, Animal; Female; Gene Knock-In Techniques; Humans; Imiquimod; Interleukin-17; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Psoriasis; T-Lymphocyte Subsets

2012
Psoriasis induced by topical imiquimod.
    The Australasian journal of dermatology, 2004, Volume: 45, Issue:1

    Topics: Administration, Cutaneous; Aminoquinolines; Antineoplastic Agents; Carcinoma, Basal Cell; Female; Humans; Imiquimod; Interferon Inducers; Middle Aged; Psoriasis; Skin; Skin Neoplasms

2004
Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.
    Archives of dermatology, 2004, Volume: 140, Issue:12

    Topics: Administration, Topical; Aminoquinolines; Biopsy; Dendritic Cells; Diagnostic Errors; Fluorescent Antibody Technique; Humans; Imiquimod; Immunohistochemistry; Interferon Inducers; Male; Membrane Glycoproteins; Middle Aged; Plasma Cells; Psoriasis; Receptors, Cell Surface; Skin; Stem Cells; Toll-Like Receptor 7; Toll-Like Receptors

2004
Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomas.
    Clinical and experimental dermatology, 2006, Volume: 31, Issue:1

    Topics: Administration, Topical; Aminoquinolines; Antineoplastic Agents; Carcinoma, Basal Cell; Drug Eruptions; Female; Humans; Imiquimod; Middle Aged; Psoriasis; Skin Neoplasms

2006
Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod.
    International journal of dermatology, 2006, Volume: 45, Issue:12

    Topics: Administration, Cutaneous; Aged; Aminoquinolines; Antineoplastic Agents; Drug Eruptions; Humans; Imiquimod; Keratosis; Male; Ointments; Psoriasis; Scalp Dermatoses

2006