Page last updated: 2024-10-29

imipramine and Weight Gain

imipramine has been researched along with Weight Gain in 12 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Weight Gain: Increase in BODY WEIGHT over existing weight.

Research Excerpts

ExcerptRelevanceReference
"In a recent study, the authors gauged the net effectiveness of imipramine to be 53%; that is, of 110 patients having panic disorder with agoraphobia who started a course of imipramine at a fixed, targeted, weight-adjusted dose of 2."9.09The side effects burden of extended imipramine treatment of panic disorder. ( Mavissakalian, MR; Perel, JM, 2000)
"In a recent study, the authors gauged the net effectiveness of imipramine to be 53%; that is, of 110 patients having panic disorder with agoraphobia who started a course of imipramine at a fixed, targeted, weight-adjusted dose of 2."5.09The side effects burden of extended imipramine treatment of panic disorder. ( Mavissakalian, MR; Perel, JM, 2000)
" Three tricyclic antidepressants examined (imipramine, clomipramine and desipramine) did not seem to have the side effect of pathological weight gain in the frequency distribution pattern."5.07Changes in the frequency distribution pattern of body weight in patients with major depression. ( Kato, T; Murashita, J; Shioiri, T; Takahashi, S; Yamada, N, 1993)
"Nefazodone treatment was associated with fewer side effects than were the control drugs."2.39The safety profile of nefazodone. ( Kaplita, SB; Marcus, RN; Roberts, DL; Robinson, DS; Seminara, JA; Smith, JM; Stringfellow, JC, 1996)
" Acute and chronic administration of psychotropic drugs (imipramine and chlordiazepoxide) showed that treatment with imipramine increased both the number of lever presses and successful escapes while chlordiazepoxide increased only the number of lever presses."1.29Evaluation of depression in rats exposed to chronic (unpredictable) electric shock. ( Hara, C; Naruo, T; Nozoe, S; Ogawa, N; Tanaka, H, 1993)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's6 (50.00)18.2507
2000's3 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Naruo, T1
Hara, C1
Nozoe, S1
Tanaka, H1
Ogawa, N1
Shioiri, T1
Kato, T1
Murashita, J1
Yamada, N1
Takahashi, S1
Robinson, DS1
Roberts, DL1
Smith, JM1
Stringfellow, JC1
Kaplita, SB1
Seminara, JA1
Marcus, RN1
Fogelson, DL1
Cash, TF1
Brown, MA1
Mavissakalian, MR1
Perel, JM1
Sussman, N1
Ginsberg, DL1
Bikoff, J1
Frank, E2
Kupfer, DJ3
Buhari, A1
McEachran, AB1
Grochocinski, VJ1
Bulik, CM1
Levenson, JA1
Noyes, R1
Garvey, MJ1
Cook, BL1
Samuelson, L1
Fernstrom, MH1
McConaha, C1
Brady, K1
Zarzar, M1
Lydiard, RB1

Reviews

2 reviews available for imipramine and Weight Gain

ArticleYear
The safety profile of nefazodone.
    The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 2

    Topics: Adolescent; Adult; Age Factors; Aged; Antidepressive Agents, Second-Generation; Antidepressive Agent

1996
Effects of nefazodone on body weight: a pooled analysis of selective serotonin reuptake inhibitor- and imipramine-controlled trials.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:4

    Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Body Weight; Controlled

2001

Trials

5 trials available for imipramine and Weight Gain

ArticleYear
Changes in the frequency distribution pattern of body weight in patients with major depression.
    Acta psychiatrica Scandinavica, 1993, Volume: 88, Issue:5

    Topics: Adult; Antidepressive Agents, Tricyclic; Body Weight; Clomipramine; Depressive Disorder; Desipramine

1993
Attitudes about antidepressants: influence of information about weight-related side effects.
    Perceptual and motor skills, 2000, Volume: 90, Issue:2

    Topics: Adolescent; Adult; Antidepressive Agents; Attitude to Health; Body Weight; Drug Information Services

2000
The side effects burden of extended imipramine treatment of panic disorder.
    Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:5

    Topics: Adult; Agoraphobia; Antidepressive Agents, Tricyclic; Blood Pressure; Female; Heart Rate; Humans; Im

2000
Imipramine and weight gain during the long-term treatment of recurrent depression.
    Journal of affective disorders, 1992, Volume: 26, Issue:1

    Topics: Adult; Body Mass Index; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Imipr

1992
Imipramine and weight gain during the treatment of recurrent depression.
    Journal of affective disorders, 1990, Volume: 20, Issue:3

    Topics: Adult; Body Mass Index; Combined Modality Therapy; Depressive Disorder; Dose-Response Relationship,

1990

Other Studies

5 other studies available for imipramine and Weight Gain

ArticleYear
Evaluation of depression in rats exposed to chronic (unpredictable) electric shock.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:3

    Topics: Animals; Behavior, Animal; Conditioning, Operant; Depression; Diazepam; Electroshock; Helplessness,

1993
Fenfluramine and the cytochrome P450 system.
    The American journal of psychiatry, 1997, Volume: 154, Issue:3

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fenfl

1997
Problems with tricyclic antidepressant use in patients with panic disorder or agoraphobia: results of a naturalistic follow-up study.
    The Journal of clinical psychiatry, 1989, Volume: 50, Issue:5

    Topics: Adult; Agoraphobia; Akathisia, Drug-Induced; Antidepressive Agents, Tricyclic; Anxiety Disorders; Ap

1989
Perception of appetite and weight change during treatment for depression.
    Appetite, 1989, Volume: 13, Issue:1

    Topics: Adult; Appetite; Body Image; Depression; Feeding Behavior; Female; Humans; Imipramine; Male; Middle

1989
Fluoxetine in panic disorder patients with imipramine-associated weight gain.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:1

    Topics: Adult; Agoraphobia; Depressive Disorder; Fear; Female; Fluoxetine; Humans; Imipramine; Middle Aged;

1989