Page last updated: 2024-10-29

imipramine and Ventricular Fibrillation

imipramine has been researched along with Ventricular Fibrillation in 11 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.

Research Excerpts

ExcerptRelevanceReference
" We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse."7.69Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine. ( Alahakoon, TI; Bentley, SC; Sandeman, DJ, 1997)
"The potential antiarrhythmic activity of imipramine against ventricular arrhythmias induced by coronary artery ligation in rats has been investigated and compared with procainamide."7.68Suppression of ventricular arrhythmias resulting from acute coronary artery ligation in rat by imipramine. ( Alhaider, AA; Bashandy, AM; el-Mahdy, SA; Mahgoub, AA, 1990)
" We present a case of massive imipramine overdose complicated by ventricular fibrillation and a prolonged period of cardiovascular collapse."3.69Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine. ( Alahakoon, TI; Bentley, SC; Sandeman, DJ, 1997)
"The potential antiarrhythmic activity of imipramine against ventricular arrhythmias induced by coronary artery ligation in rats has been investigated and compared with procainamide."3.68Suppression of ventricular arrhythmias resulting from acute coronary artery ligation in rat by imipramine. ( Alhaider, AA; Bashandy, AM; el-Mahdy, SA; Mahgoub, AA, 1990)
"Cardiac ischemia and anoxia induce massive norepinephrine (NE) release, which is mediated by a reverse operation of uptake-1 and can be suppressed by uptake-1 inhibitors."1.30Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms. ( Dart, AM; Du, XJ; Esler, MD; Little, PJ; Woodcock, EA, 1998)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19907 (63.64)18.7374
1990's3 (27.27)18.2507
2000's1 (9.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Levy, O1
Erez, M1
Varon, D1
Keinan, E1
FEKETE, M1
BORSY, J1
Manoach, M1
Watanabe, Y1
Hiroki, T1
Sandeman, DJ1
Alahakoon, TI1
Bentley, SC1
Du, XJ1
Woodcock, EA1
Little, PJ1
Esler, MD1
Dart, AM1
Zelechowska, K1
Frokiewicz, M1
el-Mahdy, SA1
Alhaider, AA1
Mahgoub, AA1
Bashandy, AM1
Levin, R1
Burtt, DM1
Levin, WA1
Ginsberg, MB1
Sesso, AM1
Snyder, RC1
Schott, CE1
Buffatti, GA1
Mariotti, M1
Rosenberg, D1
Monnet, P1
David, L1
Fayard, C1
Robin, JY1

Other Studies

11 other studies available for imipramine and Ventricular Fibrillation

ArticleYear
A new class of antiarrhythmic-defibrillatory agents.
    Bioorganic & medicinal chemistry letters, 2001, Nov-19, Volume: 11, Issue:22

    Topics: Animals; Anti-Arrhythmia Agents; Cats; Dibenzazepines; Structure-Activity Relationship; Ventricular

2001
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
    Medicina experimentalis : International journal of experimental medicine, 1964, Volume: 10

    Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound

1964
Cardiac protective effects of tricyclic antidepressants.
    The American journal of cardiology, 1984, Oct-01, Volume: 54, Issue:7

    Topics: Dibenzazepines; Humans; Imipramine; Ventricular Fibrillation

1984
Tricyclic poisoning--successful management of ventricular fibrillation following massive overdose of imipramine.
    Anaesthesia and intensive care, 1997, Volume: 25, Issue:5

    Topics: Adrenergic Agonists; Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Critical Care;

1997
Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms.
    Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Intera

1998
[Recurrent ventricular fibrillation in a patient treated with imipramine].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1977, Mar-28, Volume: 32, Issue:13

    Topics: Depression; Female; Humans; Imipramine; Middle Aged; Recurrence; Ventricular Fibrillation

1977
Suppression of ventricular arrhythmias resulting from acute coronary artery ligation in rat by imipramine.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:5

    Topics: Animals; Arrhythmias, Cardiac; Coronary Vessels; Electrocardiography; Imipramine; Male; Procainamide

1990
Ventricular fibrillation in a tetraplegic patient who had a therapeutic level of a tricyclic antidepressant. Case report.
    Paraplegia, 1985, Volume: 23, Issue:6

    Topics: Adult; Antidepressive Agents, Tricyclic; Humans; Imipramine; Male; Quadriplegia; Ventricular Fibrill

1985
Propranolol in imipramine poisoning.
    American journal of diseases of children (1960), 1973, Volume: 126, Issue:6

    Topics: Electric Countershock; Female; Gastric Lavage; Humans; Imipramine; Poisoning; Propranolol; Respirati

1973
[Severe imipramine poisoning in a 16-month-old boy].
    Minerva pediatrica, 1970, Feb-25, Volume: 22, Issue:8

    Topics: Acidosis, Respiratory; Age Factors; Bicarbonates; Coma; Humans; Imipramine; Infant; Male; Ventricula

1970
[Poisoning by imipramine and its derivatives in pediatrics. Apropos of 4 cases].
    La Presse medicale, 1969, Sep-27, Volume: 77, Issue:40

    Topics: Child, Preschool; Dibenzothiazepines; Electrocardiography; Female; Gastric Lavage; Humans; Imipramin

1969