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imipramine and Tremor

imipramine has been researched along with Tremor in 33 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Research Excerpts

ExcerptRelevanceReference
"An international, multicenter, placebo-controlled study was undertaken to determine the safety and antidepressant efficacy of moclobemide, a new reversible inhibitor of monoamine oxidase A, and imipramine in the treatment of dysthymia (DSM-III-R)."9.08Moclobemide and imipramine in chronic depression (dysthymia): an international double-blind, placebo-controlled trial. International Collaborative Study Group. ( Amrein, R; Stabl, M; Versiani, M, 1997)
"Assessment of an elderly depressed patient with an imipramine-induced tremor led to the conclusions that imipramine tremor (1) can be severe and incapacitating, (2) is most pronounced early in the treatment, (3) does not seem to be dose-related, and (4) is readily reversible with a beta-adrenergic blocking agent."7.66Imipramine-induced tremor: effects of a beta-adrenergic blocking agent. ( Greden, JF; Kronfol, Z; Zis, AP, 1983)
"Imipramine treatment further decreased harmaline-induced 5HT turnover in the brain stem."5.33Exacerbation of harmaline-induced tremor by imipramine. ( Al Deeb, S; Al Moutaery, K; Arshaduddin, M; Kadasah, S; Tariq, M, 2005)
"An international, multicenter, placebo-controlled study was undertaken to determine the safety and antidepressant efficacy of moclobemide, a new reversible inhibitor of monoamine oxidase A, and imipramine in the treatment of dysthymia (DSM-III-R)."5.08Moclobemide and imipramine in chronic depression (dysthymia): an international double-blind, placebo-controlled trial. International Collaborative Study Group. ( Amrein, R; Stabl, M; Versiani, M, 1997)
"The anticholinergic effect of atropine, imipramine, clomipramine and metapramine was evaluated on oxotremorine induced trembling in the mouse as well as on contractions of the isolated guinea pig ileum induced by electrical stimulation of the mesenteric plexus."3.67[Evaluation of the central anticholinergic activity of antidepressants. Comparison of two experimental methods]. ( Billa, JP; Dufour, P; Fabre, J; Roquebert, J, 1989)
"Assessment of an elderly depressed patient with an imipramine-induced tremor led to the conclusions that imipramine tremor (1) can be severe and incapacitating, (2) is most pronounced early in the treatment, (3) does not seem to be dose-related, and (4) is readily reversible with a beta-adrenergic blocking agent."3.66Imipramine-induced tremor: effects of a beta-adrenergic blocking agent. ( Greden, JF; Kronfol, Z; Zis, AP, 1983)
" Side effect information was collected at each visit."2.65An overview of side effects and long-term experience with nomifensine from United States clinical trials. ( Hardiman, S; Nash, RJ; Yakabow, AL, 1984)
"On treatment with imipramine, wild-type mice became sedated and produced imipramine N-oxide in the brain and other tissues."1.35Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. ( Chandan, P; Hernandez, D; Janmohamed, A; Omar, BA; Phillips, IR; Shephard, EA, 2009)
" The effect of chronic ACTH treatment on 5-HT(2) receptor and 5-HT(2A)-receptor mRNA levels was not altered by the chronic administration of imipramine."1.35Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex. ( Akiyama, K; Fujitani, Y; Gomita, Y; Kanzaki, H; Kawasaki, H; Kimoto, S; Kitagawa, K; Kitamura, Y; Ouchida, M; Sendo, T; Shibata, K; Shimizu, K, 2008)
"Imipramine treatment further decreased harmaline-induced 5HT turnover in the brain stem."1.33Exacerbation of harmaline-induced tremor by imipramine. ( Al Deeb, S; Al Moutaery, K; Arshaduddin, M; Kadasah, S; Tariq, M, 2005)
"Imipramine methiodide is a quaternary derivative of imipramine which does not cross the blood-brain barrier easily."1.27Comparison of imipramine-imipraminium in mice. To elucidate central or peripheral origin of effects of imipramine. ( Frances, H; Simon, P, 1985)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199029 (87.88)18.7374
1990's1 (3.03)18.2507
2000's3 (9.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hernandez, D1
Janmohamed, A1
Chandan, P1
Omar, BA1
Phillips, IR1
Shephard, EA1
ENGLISH, HL1
KANE, FJ1
TAYLOR, TW1
THEOBALD, W1
BUECH, O1
KUNZ, HA1
MORPURGO, C1
STENGER, EG1
WILHELMI, G1
Arshaduddin, M1
Kadasah, S1
Al Deeb, S1
Al Moutaery, K1
Tariq, M1
Kitamura, Y1
Shibata, K1
Akiyama, K1
Kimoto, S1
Fujitani, Y1
Kitagawa, K1
Kanzaki, H1
Ouchida, M1
Shimizu, K1
Kawasaki, H1
Sendo, T1
Gomita, Y1
Yakabow, AL1
Hardiman, S1
Nash, RJ1
Kronfol, Z1
Greden, JF1
Zis, AP1
Versiani, M1
Amrein, R1
Stabl, M1
Rehavi, M2
Maayani, S2
Goldstein, L1
Assael, M1
Sokolovsky, M2
Silvestrini, B1
Lisciani, R1
Angst, J2
Woggon, B2
Schoepf, J1
Cendrowski, W1
Karniol, IG1
Dalton, J1
Lader, M1
Dekret, JJ1
Maany, I1
Ramsey, TA1
Mendels, J1
Dittmer, TL1
Heinrich, K1
Hippius, H1
Seibel, I1
Dufour, P1
Billa, JP1
Fabre, J1
Roquebert, J1
Levine, S1
Deo, R1
Mahadevan, K1
Frances, H2
Simon, P1
Vaupel, DB1
Martin, WR1
Zelikman, TIa1
Shekhtman, ML1
Srimal, RC1
Singh, HK1
Dhawan, BN1
Schulterbrandt, JG1
Raskin, A1
Reatig, N1
Eggermont, E1
Raveschot, J1
Deneve, V1
Casteels-van Daele, M1
Sofia, RD1
Kubena, RK1
Barry, H1
Saraf, KR1
Klein, DF1
Gittelman-Klein, R1
Groff, S1
Jacob, J1
Nikki, P1
Lippmann, W1
Sjöqvist, F1
Hammer, W1
Schumacher, H1
Gillette, J1
Achari, G1
Sinha, SP1
Dandiya, PC1
Bhargava, LP1

Trials

7 trials available for imipramine and Tremor

ArticleYear
An overview of side effects and long-term experience with nomifensine from United States clinical trials.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:4 Pt 2

    Topics: Adult; Akathisia, Drug-Induced; Clinical Trials as Topic; Depressive Disorder; Dizziness; Headache;

1984
Moclobemide and imipramine in chronic depression (dysthymia): an international double-blind, placebo-controlled trial. International Collaborative Study Group.
    International clinical psychopharmacology, 1997, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzamides; Consti

1997
The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study.
    Archiv fur Psychiatrie und Nervenkrankheiten, 1977, Oct-11, Volume: 224, Issue:2

    Topics: 5-Hydroxytryptophan; Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Synergis

1977
[Clinical trial of lofepramine versus imipramine].
    International pharmacopsychiatry, 1975, Volume: 10, Issue:2

    Topics: Acetophenones; Adult; Clinical Trials as Topic; Constipation; Depression; Dibenzazepines; Drug Evalu

1975
A comparative trial of a new antidepressant, fluoxetine.
    The British journal of psychiatry : the journal of mental science, 1987, Volume: 150

    Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female

1987
True and apparent side effects in a controlled trial of chlorpromazine and imipramine in depression.
    Psychopharmacologia, 1974, Volume: 38, Issue:4

    Topics: Adult; Agranulocytosis; Chlorpromazine; Clinical Trials as Topic; Depression; Dermatitis; Edema; Eva

1974
Imipramine side effects in children.
    Psychopharmacologia, 1974, Jul-11, Volume: 37, Issue:3

    Topics: Adolescent; Anorexia Nervosa; Blood Pressure; Child; Constipation; Death, Sudden; Depression, Chemic

1974

Other Studies

26 other studies available for imipramine and Tremor

ArticleYear
Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.
    Pharmacogenetics and genomics, 2009, Volume: 19, Issue:4

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cells, Cultured; Chromosomes; Embryonic

2009
An alarming side-effect of tofranil.
    Lancet (London, England), 1959, Jun-13, Volume: 1, Issue:7085

    Topics: Drug-Related Side Effects and Adverse Reactions; Equipment Failure; Humans; Iatrogenic Disease; Imip

1959
An unusual reaction to combined imipramine-thorazine therapy.
    The American journal of psychiatry, 1963, Volume: 120

    Topics: Chlorpromazine; Imipramine; Reflex; Spasm; Speech Disorders; Tremor

1963
[COMPARATIVE PHARMACOLOGICAL INVESTIGATIONS WITH TOFRANIL, PERTOFRAN AND INSIDON].
    Archives internationales de pharmacodynamie et de therapie, 1964, Apr-01, Volume: 148

    Topics: Acetylcholine; Amphetamine; Amphetamines; Anesthetics; Animals; Antidepressive Agents; Catatonia; Ca

1964
Exacerbation of harmaline-induced tremor by imipramine.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:1

    Topics: Animals; Drug Synergism; Harmaline; Imipramine; Male; Rats; Rats, Sprague-Dawley; Tremor

2005
Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: possible involvement of enhanced 5-HT(2A)-receptor expression in the frontal cortex.
    Journal of pharmacological sciences, 2008, Volume: 106, Issue:1

    Topics: Adrenocorticotropic Hormone; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Binding Sites;

2008
Imipramine-induced tremor: effects of a beta-adrenergic blocking agent.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:6

    Topics: Depressive Disorder; Humans; Imipramine; Male; Middle Aged; Propranolol; Tremor

1983
Antimuscarinic properties of antidepressants: dibenzepin (Noveril).
    Psychopharmacology, 1977, Aug-31, Volume: 54, Issue:1

    Topics: Animals; Body Temperature; Dibenzazepines; Guinea Pigs; Imipramine; In Vitro Techniques; Male; Mice;

1977
Experimental data suggesting an adrenergic mechanism in the production of parkinsonian symptoms.
    Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:5

    Topics: 5-Hydroxytryptophan; Animals; Atropine; Clonidine; Female; Fenclonine; Imipramine; Male; Mice; Mice,

1976
[Attempts at pharmacological and surgical treatment of intentional and postural tremor in patients with disseminated sclerosis (authors transl)].
    Przeglad lekarski, 1976, Volume: 33, Issue:9

    Topics: Adult; Amitriptyline; Evaluation Studies as Topic; Female; Humans; Imipramine; Male; Middle Aged; Mu

1976
Comparative psychotropic effects of trazodone, imipramine and diazepam in normal subjects.
    Current therapeutic research, clinical and experimental, 1976, Volume: 20, Issue:3

    Topics: Acoustic Stimulation; Adult; Blood Pressure; Diazepam; Dose-Response Relationship, Drug; Evoked Pote

1976
Tricyclic antidepressants as antimuscarinic drugs: in vivo and in vitro studies.
    Biochemical pharmacology, 1977, Sep-01, Volume: 26, Issue:17

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Body Temperature; Brain; Cholinesterase In

1977
A case of oral dyskinesia associated with imipramine treatment.
    The American journal of psychiatry, 1977, Volume: 134, Issue:11

    Topics: Dyskinesia, Drug-Induced; Humans; Imipramine; Male; Middle Aged; Mouth; Tremor

1977
[Evaluation of the central anticholinergic activity of antidepressants. Comparison of two experimental methods].
    Annales pharmaceutiques francaises, 1989, Volume: 47, Issue:3

    Topics: Animals; Antidepressive Agents, Tricyclic; Atropine; Clomipramine; Dibenzazepines; Female; Guinea Pi

1989
Comparison of imipramine-imipraminium in mice. To elucidate central or peripheral origin of effects of imipramine.
    Neuropharmacology, 1985, Volume: 24, Issue:7

    Topics: Animals; Apomorphine; Body Temperature; Drug Synergism; Imipramine; Male; Mice; Motor Activity; Oxot

1985
Interaction of oxotremorine with atropine, chlorpromazine, cyproheptadine, imipramine and phenoxybenzamine on the flexor reflex of the chronic spinal dog.
    Psychopharmacologia, 1973, Volume: 30, Issue:1

    Topics: Animals; Atropine; Chlorpromazine; Cyproheptadine; Dogs; Drug Interactions; Imipramine; Oxotremorine

1973
[On the clinical course and therapy of pathological conditions caused by incompatible antidepressants].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1968, Volume: 68, Issue:1

    Topics: Adult; Anuria; Bipolar Disorder; Bis-Trimethylammonium Compounds; Depression; Depressive Disorder, M

1968
Experimental evidence for imipramine like activity of fenfluramine.
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 188, Issue:2

    Topics: Animals; Avoidance Learning; Blepharoptosis; Blood Pressure; Body Temperature; Cats; Columbidae; Dru

1970
The adverse influence of imipramine on the adaptation of the newborn infant to extrauterine life.
    Acta paediatrica Belgica, 1972, Volume: 26, Issue:4

    Topics: Cyanosis; Depression; Female; Fetal Diseases; Fetus; Heart Failure; Humans; Imipramine; Infant, Newb

1972
Inactivity of delta9-tetrahydrocannabinol in antidepressant screening tests.
    Psychopharmacologia, 1973, Jul-17, Volume: 31, Issue:2

    Topics: Animals; Antidepressive Agents; Atropine; Behavior, Animal; Body Temperature; Cannabis; Dronabinol;

1973
[Comparison of the effects of cholinergic and anticholinergic substances on the cerebral content of acetylcholine and on the motility of mice].
    Psychopharmacologia, 1971, Volume: 21, Issue:4

    Topics: Acetylcholine; Amphetamine; Animals; Atropine; Benactyzine; Brain Chemistry; Glycolates; Imipramine;

1971
Arecoline and halothane shivering in thyroxine-treated mice.
    Annales medicinae experimentalis et biologiae Fenniae, 1969, Volume: 47, Issue:3

    Topics: Adjuvants, Anesthesia; Anesthesia, Inhalation; Animals; Body Temperature; Halothane; Hyperthyroidism

1969
Blockade of norepinephrine uptake and related activities of cis- and trans-N,N'-bis-(1-naphthylmethyl)-1,4-cyclohexane bis-(methylamine) dihydrochloride.
    Biochemical pharmacology, 1970, Volume: 19, Issue:5

    Topics: Adipose Tissue; Amines; Animals; Atropine; Chlorpromazine; Cyclohexanes; Desipramine; Drug Antagonis

1970
[The effect of desmethylimipramine and other "anti-tremorine" drugs on the metabolism of tremorine and oxotremorine in rats and mice].
    Biochemical pharmacology, 1968, Volume: 17, Issue:6

    Topics: Animals; Body Temperature; Brain; Desipramine; Drug Synergism; Imipramine; Liver; Male; Malonates; M

1968
Evaluation of certain psychoanaleptic drugs as anti-parkinsonian agent: an experimental study.
    The Indian journal of medical research, 1968, Volume: 56, Issue:4

    Topics: Amitriptyline; Animals; Female; Imipramine; Male; Rats; Tremor

1968
The antiparkinsonian activity of monoamine oxidase inhibitors and other agents in rats and mice.
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 176, Issue:1

    Topics: Animals; Dextroamphetamine; Diphenhydramine; Imipramine; Iproniazid; Isocarboxazid; Mice; Monoamine

1968