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imipramine and Substance Withdrawal Syndrome

imipramine has been researched along with Substance Withdrawal Syndrome in 80 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Research Excerpts

ExcerptRelevanceReference
" The aim of the present study was to assess the 12-month cumulative risk of relapse specifically due to discontinuation of imipramine and to test the hypothesis that maintenance treatment with imipramine protects patients with panic disorder and agoraphobia from such reversals."9.09Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. ( Mavissakalian, MR; Perel, JM, 1999)
" We tested if blockade or activation of serotonin (5-HT)(2) receptors affected the time of immobility (as an indirect measure of depression-like behavior) in naïve animals and in those withdrawn from chronic nicotine in the forced swim test (FST)."7.76Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal. ( Filip, M; McCreary, AC; Wydra, K; Zaniewska, M, 2010)
" The aim of the present study was to assess the 12-month cumulative risk of relapse specifically due to discontinuation of imipramine and to test the hypothesis that maintenance treatment with imipramine protects patients with panic disorder and agoraphobia from such reversals."5.09Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia. ( Mavissakalian, MR; Perel, JM, 1999)
"Forty-eight patients with panic disorder completing 8 months of maintenance treatment with alprazolam (mean dose, 5."5.07Maintenance drug treatment for panic disorder. II. Short- and long-term outcome after drug taper. ( Rickels, K; Schweizer, E; Weiss, S; Zavodnick, S, 1993)
"In this study adult female Wistar and Wistar-Kyoto (WKY) rats, a putative animal model of depression, were exposed to alcohol vapor 3h daily for 10days (blood alcohol concentration ∼150mg%) followed by daily injection of 10mg/kg of imipramine (IMP, a selective norepinephrine NE/serotonin reuptake inhibitor) or nomifensine (NOMI, a selective NE/dopamine reuptake inhibitor)."3.85Role of cortical alpha-2 adrenoceptors in alcohol withdrawal-induced depression and tricyclic antidepressants. ( Csoka, AB; Getachew, B; Hauser, SR; Taylor, RE; Tizabi, Y, 2017)
"Thus, our results suggest that the reduced IL-4 and IL-10 levels in serum with hippocampal M2 markers may be involved in the stress vulnerability after imipramine discontinuation, and the restoration and modulation of these factors may be useful to some forms of depression-associated conditions."3.81IL-4/10 prevents stress vulnerability following imipramine discontinuation. ( Choi, HJ; Han, A; Hong, CW; Kim, SH; Kwon, MS; Park, MJ; Yeo, H, 2015)
" We tested if blockade or activation of serotonin (5-HT)(2) receptors affected the time of immobility (as an indirect measure of depression-like behavior) in naïve animals and in those withdrawn from chronic nicotine in the forced swim test (FST)."3.76Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal. ( Filip, M; McCreary, AC; Wydra, K; Zaniewska, M, 2010)
"The escape behaviour induced in rats by injecting D,L-homocysteic acid (DHL) into the dorsal periaqueductal grey area (DPAG) was used as an animal model of panic attacks to investigate the effect of imipramine, a drug used for the treatment of panic disorder, on the sensitivity of 5-HT1A receptors in the DPAG."3.69Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats. ( Marsden, CA; Mongeau, R, 1997)
"Measures of subjective feeling used by five patients indicated that depression of mood occurred about four days after fenfluramine withdrawal."3.65Drugs of dependence though not of abuse: fenfluramine and imipramine. ( Brezinova, V; Briggs, M; Dunleavy, DL; Lewis, SA; Oswald, I, 1971)
"The imipramine effect was greater among nasal users--33% (9/27) response on imipramine vs."2.68Imipramine treatment of cocaine abuse: possible boundaries of efficacy. ( Klein, DF; Koenig, T; McGrath, PJ; Nunes, EV; Ocepek-Welikson, K; Quitkin, FM; Stewart, JW; Wager, S, 1995)
"Imipramine 10 mg/day was the control condition."2.67Imipramine for the treatment of cocaine and methamphetamine dependence. ( Galloway, GP; Knapp, T; Newmeyer, J; Smith, D; Stalcup, SA, 1994)
" Our study indicates that the discontinuation of diazepam, even when given in moderate dosage over a relatively short period of time, may cause withdrawal reactions in combined antidepressant/diazepam treatment."2.66Withdrawal reactions to diazepam in combined imipramine/diazepam treatment of primary nonagitated depressed outpatients. ( Feet, PO; Larsen, S; Lillevold, PE; Robak, OH, 1988)
"Amitriptyline was not found in plasma 14 days after its withdrawal, while at the same time its levels in erythrocytes were still well measurable."1.28Plasma levels of antidepressants after their withdrawal. ( Beitlová, D; Krulík, R; Príhoda, P; Sikora, J, 1990)
"Significant withdrawal symptoms were found over seven symptom categories despite an average tapering period of 6."1.26Withdrawal symptoms after graduated cessation of imipramine in children. ( Kazdin, AE; Law, W; Petti, TA, 1981)
"The authors describe 2 cases in which withdrawal symptoms occurred during the course of imipramine therapy, after the patients had failed to take a single daily dose of medication."1.26Withdrawal symptoms during the course of imipramine therapy. ( Mendels, J; Stern, SL, 1980)

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199047 (58.75)18.7374
1990's16 (20.00)18.2507
2000's12 (15.00)29.6817
2010's5 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Getachew, B1
Hauser, SR1
Csoka, AB1
Taylor, RE1
Tizabi, Y1
Han, A1
Yeo, H1
Park, MJ1
Kim, SH1
Choi, HJ1
Hong, CW1
Kwon, MS1
Marszalek-Grabska, M1
Gibula-Bruzda, E1
Jenda, M1
Gawel, K1
Kotlinska, JH1
Green, AD1
Barr, AM1
Galea, LA1
dos Santos, L1
de Andrade, TG1
Graeff, FG1
Zaniewska, M1
McCreary, AC1
Wydra, K1
Filip, M1
D'Aquila, PS2
Peana, AT1
Panin, F2
Grixoni, C1
Cossu, M1
Serra, G2
Mavissakalian, MR1
Perel, JM1
KRAMER, JC1
KLEIN, DF2
FINK, M1
McMahon, LR2
Sell, SL2
France, CP2
Koek, W1
Yoshida, K1
Sugawara, Y1
Higuchi, H1
Harvey, BH2
Retief, R1
Korff, A1
Wegener, G1
Simon, P1
Telch, MJ1
Tearnan, BH1
Taylor, CB1
Verberne, AJ1
Taylor, DA1
Fennessy, MR1
Dilsaver, SC1
Greden, JF2
Jones, BD1
Steinberg, S1
Chouinard, G2
Katerndahl, DA1
Shrand, H1
Law, W2
Petti, TA2
Kazdin, AE1
Boisvert, D1
Stern, SL1
Mendels, J1
Mirin, SM1
Schatzberg, AF1
Creasey, DE1
Fukase, H1
Fukuzaki, K1
Koja, T1
Nagata, R1
Lukas, SE1
Galloway, GP1
Newmeyer, J1
Knapp, T1
Stalcup, SA1
Smith, D1
McGrath, PJ2
Stewart, JW2
Tricamo, E1
Nunes, EN1
Quitkin, FM2
Rickels, K2
Schweizer, E1
Weiss, S1
Zavodnick, S1
Nunes, EV1
Ocepek-Welikson, K1
Koenig, T1
Wager, S1
Pathiraja, A1
Marazziti, D1
Cassano, GB1
Diamond, BI1
Borison, RL1
Spanier, C1
Frank, E1
McEachran, AB1
Grochocinski, VJ1
Kupfer, DJ1
Belej, T1
Manji, D1
Sioutis, S1
Barros, HM1
Nobrega, JN1
Mongeau, R1
Marsden, CA1
Perera, M1
Khan, MA1
DeMartinis, N1
García-España, F1
Greenblatt, DJ1
Mandos, LA1
Rynn, M1
Sontheimer, DL1
Ables, AZ1
Altshuler, L1
Kiriakos, L1
Calcagno, J1
Goodman, R1
Gitlin, M1
Frye, M1
Mintz, J1
Gupta, R2
Gupta, N1
Avasthi, A1
Jonker, LP1
Brand, L1
Heenop, M1
Stein, DJ1
Seltzer, V1
Tonge, SR1
Kissin, B2
Gold, MS1
Pottash, AL1
Sweeney, DR1
Kleber, HD1
Redmond, DE1
Gardos, G1
Kalman, T1
Warner, GM1
Gire, C1
Dubus, JC1
Garnier, JM1
Unal, D1
Babb, SV1
Dunlop, SR1
Hoffmann, MA1
Kusalic, M1
Ghadirian, AM1
Sikora, J1
Krulík, R1
Beitlová, D1
Príhoda, P1
Fellhauer, M1
Regan, WM1
Margolin, RA1
Mathew, RJ1
Tandon, R1
Dutchak, D1
Sunderland, G1
Friedman, S1
Rosenblum, LA1
Eppel, AB1
Feet, PO1
Larsen, S1
Lillevold, PE1
Robak, OH1
Kishnir, SL1
Siris, SG1
Strahan, A1
Merriam, AE2
Ginsberg, HN1
Nabeshima, T1
Yamaguchi, K1
Yoshida, S1
Furukawa, H1
Kameyama, T1
Narang, RL1
Burnett, GB1
Holland, PJ1
Shrivastava, RK1
Itil, TM1
Eggermont, E1
Jhamandas, K1
Sutak, M1
Bell, S1
Avrutskii, GIa1
Gurovich, IIa1
Prokhorova, IS1
Tirkel'taub, IuA1
Romanov, IuD1
Lewis, SA2
Oswald, I2
Gross, MM1
Drew, WG1
Chamblin, M1
Miller, LL1
Kamei, C1
Shimomura, K1
Ueki, S1
Kaneto, H1
Koida, M1
Tsuchie, F1
Sathananthan, GL1
Gershon, S1
Butterworth, AT1
Crisp, AH1
Dunleavy, DL1
Brezinova, V1
Briggs, M1
Chiosa, L1
Dumitrescu, S1
Banaru, A1
Dallos, V1
Heathfield, K1
Shatan, C1

Reviews

2 reviews available for imipramine and Substance Withdrawal Syndrome

ArticleYear
Antidepressant medication in the treatment of agoraphobia: a critical review.
    Behaviour research and therapy, 1983, Volume: 21, Issue:5

    Topics: Agoraphobia; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior Therapy; Clomipramine

1983
Antidepressant withdrawal phenomena.
    Biological psychiatry, 1984, Volume: 19, Issue:2

    Topics: Adult; Amitriptyline; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac;

1984

Trials

8 trials available for imipramine and Substance Withdrawal Syndrome

ArticleYear
Long-term maintenance and discontinuation of imipramine therapy in panic disorder with agoraphobia.
    Archives of general psychiatry, 1999, Volume: 56, Issue:9

    Topics: Adult; Agoraphobia; Antidepressive Agents, Tricyclic; Double-Blind Method; Drug Administration Sched

1999
Imipramine for the treatment of cocaine and methamphetamine dependence.
    Journal of addictive diseases, 1994, Volume: 13, Issue:4

    Topics: Cocaine; Combined Modality Therapy; Counseling; Dose-Response Relationship, Drug; Double-Blind Metho

1994
Maintenance drug treatment for panic disorder. II. Short- and long-term outcome after drug taper.
    Archives of general psychiatry, 1993, Volume: 50, Issue:1

    Topics: Adult; Alprazolam; Ambulatory Care; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admi

1993
Imipramine treatment of cocaine abuse: possible boundaries of efficacy.
    Drug and alcohol dependence, 1995, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Cocaine; Combined Modality Therapy; Comor

1995
The prophylaxis of depressive episodes in recurrent depression following discontinuation of drug therapy: integrating psychological and biological factors.
    Psychological medicine, 1996, Volume: 26, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Depressive Disorder; Female; Fol

1996
Imipramine and buspirone in treatment of patients with generalized anxiety disorder who are discontinuing long-term benzodiazepine therapy.
    The American journal of psychiatry, 2000, Volume: 157, Issue:12

    Topics: Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Benzodiazepin

2000
Withdrawal reactions to diazepam in combined imipramine/diazepam treatment of primary nonagitated depressed outpatients.
    Acta psychiatrica Scandinavica, 1988, Volume: 78, Issue:3

    Topics: Clinical Trials as Topic; Depressive Disorder; Desipramine; Diazepam; Double-Blind Method; Drug Ther

1988
Depression associated with alcohol withdrawal. Imipramine therapy compared with placebo.
    Quarterly journal of studies on alcohol, 1971, Volume: 32, Issue:2

    Topics: Adult; Alcoholism; Clinical Trials as Topic; Depression; Diarrhea; Humans; Imipramine; Male; Middle

1971

Other Studies

70 other studies available for imipramine and Substance Withdrawal Syndrome

ArticleYear
Role of cortical alpha-2 adrenoceptors in alcohol withdrawal-induced depression and tricyclic antidepressants.
    Drug and alcohol dependence, 2017, 06-01, Volume: 175

    Topics: Animals; Antidepressive Agents, Tricyclic; Blood Alcohol Content; Depression; Disease Models, Animal

2017
IL-4/10 prevents stress vulnerability following imipramine discontinuation.
    Journal of neuroinflammation, 2015, Oct-31, Volume: 12

    Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Depression; Electroshock; Expl

2015
Memantine improves memory impairment and depressive-like behavior induced by amphetamine withdrawal in rats.
    Brain research, 2016, 07-01, Volume: 1642

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Antidepressive Agents; Central Nervous System S

2016
Role of estradiol withdrawal in 'anhedonic' sucrose consumption: a model of postpartum depression.
    Physiology & behavior, 2009, May-25, Volume: 97, Issue:2

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Body Weight; Depression, Postpartum; Disease M

2009
Social separation and diazepam withdrawal increase anxiety in the elevated plus-maze and serotonin turnover in the median raphe and hippocampus.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:5

    Topics: Acute Disease; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Chronic Disease; Diazepam;

2010
Effects of serotonin (5-HT)2 receptor ligands on depression-like behavior during nicotine withdrawal.
    Neuropharmacology, 2010, Volume: 58, Issue:7

    Topics: Animals; Antidepressive Agents, Tricyclic; Depression; Imipramine; Male; Motor Activity; Neuropsycho

2010
Reversal of antidepressant-induced dopaminergic behavioural supersensitivity after long-term chronic imipramine withdrawal.
    European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Dopamine; Dopamine Agonists;

2003
Withdrawal symptoms following dicontinuation of imipramine therapy.
    The American journal of psychiatry, 1961, Volume: 118

    Topics: Imipramine; Psychopharmacology; Substance Withdrawal Syndrome

1961
Cocaine and other indirect-acting monoamine agonists differentially attenuate a naltrexone discriminative stimulus in morphine-treated rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 308, Issue:1

    Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Discrimination Learning; Disease Models, Animal;

2004
Long-term imipramine withdrawal induces a depressive-like behaviour in the forced swimming test.
    European journal of pharmacology, 2004, May-10, Volume: 492, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Disease Models, Animal; Imi

2004
Monoaminergic drugs and directly observable signs of LAAM withdrawal in rhesus monkeys.
    Behavioural pharmacology, 2005, Volume: 16, Issue:1

    Topics: Adrenergic alpha-Agonists; Amphetamine; Analgesics, Opioid; Animals; Antidepressive Agents, Tricycli

2005
Dramatic remission of treatment-resistant depression after the cessation of tricyclic antidepressants.
    Pharmacopsychiatry, 2006, Volume: 39, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Cabergoline; Depressive Disorder, Major; Dose-Response Rela

2006
Increased hippocampal nitric oxide synthase activity and stress responsiveness after imipramine discontinuation: role of 5HT 2A/C-receptors.
    Metabolic brain disease, 2006, Volume: 21, Issue:2-3

    Topics: Animals; Antidepressive Agents, Tricyclic; Hippocampus; Imipramine; Male; Nitric Oxide Synthase Type

2006
Antidepressants, benzodiazepines, and convulsions.
    Biological psychiatry, 1983, Volume: 18, Issue:4

    Topics: Adult; Anti-Anxiety Agents; Clorazepate Dipotassium; Female; Humans; Imipramine; Seizures; Substance

1983
Withdrawal-like behaviour induced by inhibitors of biogenic amine reuptake in rats treated chronically with delta 9-tetrahydrocannabinol.
    Psychopharmacology, 1980, Volume: 68, Issue:3

    Topics: Animals; Biogenic Amines; Body Weight; Clomipramine; Dronabinol; Eating; Fluoxetine; Humans; Imipram

1980
Fast-cycling bipolar disorder induced by withdrawal from long-term treatment with a tricyclic antidepressant.
    The American journal of psychiatry, 1984, Volume: 141, Issue:1

    Topics: Bipolar Disorder; Depressive Disorder; Female; Humans; Imipramine; Middle Aged; Substance Withdrawal

1984
Panic.
    American family physician, 1982, Volume: 26, Issue:1

    Topics: Adult; Anxiety Disorders; Cardiovascular Diseases; Endocrine System Diseases; Fear; Female; Humans;

1982
Agoraphobia and imipramine withdrawal?
    Pediatrics, 1982, Volume: 70, Issue:5

    Topics: Agoraphobia; Female; Humans; Imipramine; Infant, Newborn; Infant, Newborn, Diseases; Phobic Disorder

1982
Withdrawal symptoms after graduated cessation of imipramine in children.
    The American journal of psychiatry, 1981, Volume: 138, Issue:5

    Topics: Anorexia; Child; Depressive Disorder; Fatigue; Female; Gastrointestinal Diseases; Headache; Humans;

1981
Abrupt cessation of high-dose imipramine treatment in children.
    JAMA, 1981, Aug-14, Volume: 246, Issue:7

    Topics: Child; Dangerous Behavior; Headache; Humans; Imipramine; Male; Patient Compliance; Sleep Stages; Sub

1981
Rebound cardiac arrhythmia after withdrawal from imipramine: a case report.
    The American journal of psychiatry, 1981, Volume: 138, Issue:7

    Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Female; Humans; Imipramine; Middle Aged; Substance Wit

1981
Withdrawal symptoms during the course of imipramine therapy.
    The Journal of clinical psychiatry, 1980, Volume: 41, Issue:2

    Topics: Adult; Depression; Drug Administration Schedule; Female; Humans; Imipramine; Male; Substance Withdra

1980
Hypomania and mania after withdrawal of tricyclic antidepressants.
    The American journal of psychiatry, 1981, Volume: 138, Issue:1

    Topics: Adult; Affective Disorders, Psychotic; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Diso

1981
Effects of morphine, naloxone, buprenorphine, butorphanol, haloperidol and imipramine on morphine withdrawal signs in cynomolgus monkeys.
    Psychopharmacology, 1994, Volume: 116, Issue:4

    Topics: Animals; Behavior, Animal; Buprenorphine; Butorphanol; Haloperidol; Imipramine; Macaca fascicularis;

1994
Paradoxical mood shifts to euthymia or hypomania upon withdrawal of antidepressant agents.
    Journal of clinical psychopharmacology, 1993, Volume: 13, Issue:3

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramine; Male;

1993
Phenomenology and neurobiology of cocaine withdrawal: are they related?
    Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:6

    Topics: Adult; Affect; Binding, Competitive; Cocaine; Female; Humans; Imipramine; Male; Psychiatric Status R

1995
Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects.
    Brain research, 1996, Oct-14, Volume: 736, Issue:1-2

    Topics: Administration, Oral; Animals; Autoradiography; Biological Transport; Brain; Carrier Proteins; Cocai

1996
Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats.
    Psychopharmacology, 1997, Volume: 131, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antidepressive Agents, Tricyc

1997
Testicular pain and swelling on withdrawal of imipramine.
    The British journal of psychiatry : the journal of mental science, 1998, Volume: 173

    Topics: Antidepressive Agents, Tricyclic; Edema; Humans; Imipramine; Male; Middle Aged; Pain; Substance With

1998
Is imipramine or buspirone treatment effective in patients wishing to discontinue long-term benzodiazepine use?
    The Journal of family practice, 2001, Volume: 50, Issue:3

    Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Double-Blind Method

2001
The impact of antidepressant discontinuation versus antidepressant continuation on 1-year risk for relapse of bipolar depression: a retrospective chart review.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:8

    Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Drug Administrati

2001
Benzodiazepine discontinuation in generalized anxiety disorder.
    The American journal of psychiatry, 2002, Volume: 159, Issue:2

    Topics: Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Humans; Imipramine; Long-Term Ca

2002
NMDA receptor involvement in imipramine withdrawal-associated effects on swim stress, GABA levels and NMDA receptor binding in rat hippocampus.
    Life sciences, 2002, May-24, Volume: 71, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Chromatogr

2002
Proceedings: Methylamphetamine withdrawal as a model for the depressive state: antagonism of post-amphetamine depression by imipramine.
    The Journal of pharmacy and pharmacology, 1975, Volume: 27 Suppl?-2

    Topics: Animals; Brain Chemistry; Depression; Disease Models, Animal; Humans; Imipramine; Male; Methamphetam

1975
The use of psychoactive drugs in the long-term treatment of chronic alcoholics.
    Annals of the New York Academy of Sciences, 1975, Apr-25, Volume: 252

    Topics: Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Ch

1975
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
    The American journal of psychiatry, 1979, Volume: 136, Issue:7

    Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me

1979
A case of withdrawal dyskinesia.
    The American journal of psychiatry, 1979, Volume: 136, Issue:8

    Topics: Benztropine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Humans; Imipramine; Middle Aged; S

1979
Protracted vomiting following abrupt cessation of psychotropics: a case report.
    Canadian Psychiatric Association journal, 1978, Volume: 23, Issue:3

    Topics: Adult; Benztropine; Depression; Drug Therapy, Combination; Haloperidol; Humans; Imipramine; Male; Sc

1978
[Imipramine withdrawal syndrome during a treatment for enuresis].
    Pediatrie, 1992, Volume: 47, Issue:12

    Topics: Adolescent; Enuresis; Humans; Imipramine; Male; Substance Withdrawal Syndrome

1992
Protracted ventricular arrhythmias occurring after abrupt tricyclic antidepressant withdrawal.
    Psychosomatics, 1990,Fall, Volume: 31, Issue:4

    Topics: Depressive Disorder; Desipramine; Electrocardiography; Humans; Imipramine; Male; Middle Aged; Substa

1990
Paradoxical mood changes during pharmacotherapy of bipolar patients.
    Biological psychiatry, 1990, May-15, Volume: 27, Issue:10

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Imipramine; Lithium; Phenelzine; Subst

1990
Plasma levels of antidepressants after their withdrawal.
    Endocrinologia experimentalis, 1990, Volume: 24, Issue:1-2

    Topics: Adrenal Glands; Adrenalectomy; Amitriptyline; Animals; Dealkylation; Erythrocytes; Imipramine; Liver

1990
[Drug treatment of nicotine dependence].
    Medizinische Monatsschrift fur Pharmazeuten, 1990, Volume: 13, Issue:6

    Topics: Clonidine; Doxepin; Humans; Imipramine; Mecamylamine; Nicotine; Smoking; Substance Withdrawal Syndro

1990
Cardiac arrhythmia following rapid imipramine withdrawal.
    Biological psychiatry, 1989, Feb-15, Volume: 25, Issue:4

    Topics: Bipolar Disorder; Cardiac Complexes, Premature; Electrocardiography; Female; Humans; Imipramine; Lit

1989
Cholinergic syndrome following anticholinergic withdrawal in a schizophrenic patient abusing marijuana.
    The British journal of psychiatry : the journal of mental science, 1989, Volume: 154

    Topics: Adult; Benztropine; Brain; Humans; Imipramine; Male; Marijuana Abuse; Receptors, Cholinergic; Schizo

1989
Imipramine and alprazolam treatment of lactate-induced acute endogenous distress in nonhuman primates.
    The American journal of psychiatry, 1989, Volume: 146, Issue:8

    Topics: Alprazolam; Animals; Anxiety Disorders; Behavior, Animal; Conditioning, Psychological; Fear; Homing

1989
Imipramine and clonazepam for panic disorder.
    The American journal of psychiatry, 1989, Volume: 146, Issue:2

    Topics: Anxiety Disorders; Clonazepam; Depressive Disorder; Drug Therapy, Combination; Fear; Humans; Imipram

1989
Hematemesis following discontinuation of psychoactive drugs in geriatric patients.
    Journal of the American Geriatrics Society, 1988, Volume: 36, Issue:11

    Topics: Aged; Chlorpromazine; Female; Haloperidol; Hematemesis; Humans; Imipramine; Male; Procyclidine; Psyc

1988
Continuation and maintenance treatment trials of adjunctive imipramine therapy in patients with postpsychotic depression.
    The Journal of clinical psychiatry, 1988, Volume: 49, Issue:11

    Topics: Benztropine; Depressive Disorder; Drug Therapy, Combination; Fluphenazine; Humans; Imipramine; Psych

1988
Withdrawal NMS after drug treatment.
    Biological psychiatry, 1988, Volume: 24, Issue:3

    Topics: Amitriptyline; Drug Therapy, Combination; Haloperidol; Humans; Imipramine; Neuroleptic Malignant Syn

1988
Propranolol in the treatment of restless legs syndrome induced by imipramine withdrawal.
    The American journal of psychiatry, 1986, Volume: 143, Issue:7

    Topics: Depressive Disorder; Female; Humans; Imipramine; Middle Aged; Propranolol; Restless Legs Syndrome; S

1986
Phencyclidine-induced wet-dog shakes observed in rats after withdrawal from reserpine treatment.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:5

    Topics: Animals; Behavior, Animal; Imipramine; Male; Mianserin; p-Chloroamphetamine; Phencyclidine; Rats; Ra

1986
Neuroleptic malignant syndrome after imipramine withdrawal.
    Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:1

    Topics: Adult; Female; Humans; Imipramine; Neuroleptic Malignant Syndrome; Substance Withdrawal Syndrome

1987
Mania induced by gradual withdrawal from long-term treatment with imipramine.
    The American journal of psychiatry, 1986, Volume: 143, Issue:2

    Topics: Bipolar Disorder; Depressive Disorder; Humans; Imipramine; Male; Middle Aged; Substance Withdrawal S

1986
Imipramine: withdrawal and urticaria.
    Southern medical journal, 1985, Volume: 78, Issue:1

    Topics: Adult; Female; Humans; Imipramine; Substance Withdrawal Syndrome; Urticaria

1985
Flu-like illness after discontinuance of imipramine.
    Biological psychiatry, 1985, Volume: 20, Issue:7

    Topics: Adult; Depressive Disorder; Female; Humans; Imipramine; Male; Middle Aged; Nausea; Substance Withdra

1985
Withdrawal symptoms in neonates associated with maternal imipramine therapy.
    Lancet (London, England), 1973, Sep-22, Volume: 2, Issue:7830

    Topics: Female; Fetus; Humans; Imipramine; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchan

1973
Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms.
    European journal of pharmacology, 1973, Volume: 24, Issue:3

    Topics: Animals; Atropine; Autonomic Nervous System; Diphenhydramine; Dose-Response Relationship, Drug; Drug

1973
[Sudden cessation of psychotropic drugs].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:6

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Bipolar Disorder; Blood Pressure; Chlorprom

1974
Overdose of tricyclic anti-depressants and deductions concerning their cerebral action.
    The British journal of psychiatry : the journal of mental science, 1969, Volume: 115, Issue:529

    Topics: Adolescent; Adult; Amitriptyline; Brain; Brain Chemistry; Dreams; Electroencephalography; Female; Hu

1969
Drug therapy in alcoholism.
    Current psychiatric therapies, 1970, Volume: 10

    Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox

1970
Comparison of the effects of cyclazocine and imipramine on the circadian sleep-waking cycle of the cat.
    Pharmacology, 1971, Volume: 6, Issue:6

    Topics: Administration, Oral; Analgesics; Animals; Azocines; Behavior, Animal; Cats; Circadian Rhythm; Cycla

1971
Significance of withdrawal jumping response in predicting physical dependence in mice.
    Japanese journal of pharmacology, 1973, Volume: 23, Issue:3

    Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imip

1973
[Tolerance and physical dependence producing liability of doxepin].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:6

    Topics: Amitriptyline; Animals; Body Weight; Diazepam; Dibenzoxepins; Drug Resistance; Humans; Imipramine; M

1972
Imipramine withdrawal: an akathisia-like syndrome.
    The American journal of psychiatry, 1973, Volume: 130, Issue:11

    Topics: Adult; Anxiety; Brain Chemistry; Dopamine; Female; Humans; Imipramine; Male; Middle Aged; Motor Acti

1973
Slow constant intravenous infusion of imipramine up to 850 mgm/day in patients with affective illness.
    Current therapeutic research, clinical and experimental, 1966, Volume: 8, Issue:1

    Topics: Blood; Depression; Female; Humans; Imipramine; Infusions, Parenteral; Substance Withdrawal Syndrome;

1966
Drugs of dependence though not of abuse: fenfluramine and imipramine.
    British medical journal, 1971, Jul-10, Volume: 3, Issue:5766

    Topics: Adult; Appetite Depressants; Body Weight; Depression; Dreams; Female; Fenfluramine; Fluorine; Humans

1971
The influence of imipramine on the "abstinence syndrome" to morphine in mice.
    International journal of neuropharmacology, 1968, Volume: 7, Issue:2

    Topics: Animals; Humans; Imipramine; Male; Mice; Morphine; Nalorphine; Postural Balance; Substance Withdrawa

1968
Iatrogenic epilepsy due to antidepressant drugs.
    British medical journal, 1969, Oct-11, Volume: 4, Issue:5675

    Topics: Adolescent; Adult; Alcoholism; Amitriptyline; Antidepressive Agents; Barbiturates; Brain Damage, Chr

1969
Withdrawal symptoms after abrupt termination of imipramine.
    Canadian Psychiatric Association journal, 1966, Volume: 11 Suppl

    Topics: Adult; Depression; Drug Tolerance; Humans; Imipramine; Male; Parent-Child Relations; Personality; Su

1966