imipramine has been researched along with Substance-Related Disorders in 45 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Substance-Related Disorders: Disorders related to substance use or abuse.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors followed 29 young adults who had been treated for enuresis with imipramine hydrochloride 10 years earlier." | 7.66 | Enuresis treatment with imipramine hydrochloride: a 10-year follow-up study. ( Bindelglas, PM; Dee, G, 1978) |
| "The authors followed 29 young adults who had been treated for enuresis with imipramine hydrochloride 10 years earlier." | 3.66 | Enuresis treatment with imipramine hydrochloride: a 10-year follow-up study. ( Bindelglas, PM; Dee, G, 1978) |
| "Measures of subjective feeling used by five patients indicated that depression of mood occurred about four days after fenfluramine withdrawal." | 3.65 | Drugs of dependence though not of abuse: fenfluramine and imipramine. ( Brezinova, V; Briggs, M; Dunleavy, DL; Lewis, SA; Oswald, I, 1971) |
| "The imipramine effect was greater among nasal users--33% (9/27) response on imipramine vs." | 2.68 | Imipramine treatment of cocaine abuse: possible boundaries of efficacy. ( Klein, DF; Koenig, T; McGrath, PJ; Nunes, EV; Ocepek-Welikson, K; Quitkin, FM; Stewart, JW; Wager, S, 1995) |
| "Imipramine 10 mg/day was the control condition." | 2.67 | Imipramine for the treatment of cocaine and methamphetamine dependence. ( Galloway, GP; Knapp, T; Newmeyer, J; Smith, D; Stalcup, SA, 1994) |
| "psychogenic dissociation is considered." | 1.28 | Organic dissociative syndrome associated with antimigraine pharmacotherapy. ( Good, MI, 1991) |
| " Antenatal patients taking a once-daily dosage of prophylactic iron were more co-operative than those taking divided dosages." | 1.25 | Drug defaulting in a general practice. ( Porter, AM, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (73.33) | 18.7374 |
| 1990's | 9 (20.00) | 18.2507 |
| 2000's | 3 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amitai, Y | 1 |
| Frischer, H | 1 |
| Berlim, MT | 1 |
| Turecki, G | 1 |
| Stemmelin, J | 1 |
| Cohen, C | 1 |
| Terranova, JP | 1 |
| Lopez-Grancha, M | 1 |
| Pichat, P | 1 |
| Bergis, O | 1 |
| Decobert, M | 1 |
| Santucci, V | 1 |
| Françon, D | 1 |
| Alonso, R | 1 |
| Stahl, SM | 1 |
| Keane, P | 1 |
| Avenet, P | 1 |
| Scatton, B | 1 |
| le Fur, G | 1 |
| Griebel, G | 1 |
| Mellerup, ET | 1 |
| Plenge, P | 1 |
| Rosenberg, R | 1 |
| Kulik, AV | 1 |
| Wilbur, R | 1 |
| White, JH | 1 |
| Busch, KT | 1 |
| Schulz, H | 1 |
| Galloway, GP | 1 |
| Newmeyer, J | 1 |
| Knapp, T | 1 |
| Stalcup, SA | 1 |
| Smith, D | 1 |
| Siris, SG | 1 |
| Mason, SE | 1 |
| Bermanzohn, PC | 1 |
| Shuwall, MA | 1 |
| Aseniero, MA | 1 |
| Nunes, EV | 2 |
| McGrath, PJ | 1 |
| Quitkin, FM | 3 |
| Ocepek-Welikson, K | 1 |
| Stewart, JW | 2 |
| Koenig, T | 1 |
| Wager, S | 1 |
| Klein, DF | 2 |
| Belej, T | 1 |
| Manji, D | 1 |
| Sioutis, S | 1 |
| Barros, HM | 1 |
| Nobrega, JN | 1 |
| Wilkins, JN | 1 |
| Kissin, B | 1 |
| Pinder, RM | 1 |
| Brogden, RN | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Gold, MS | 1 |
| Pottash, AL | 1 |
| Sweeney, DR | 1 |
| Kleber, HD | 1 |
| Redmond, DE | 1 |
| Bindelglas, PM | 1 |
| Dee, G | 1 |
| Constantinescu, C | 1 |
| Petit, JM | 1 |
| Biggs, JT | 1 |
| Shopsin, B | 1 |
| Kline, NS | 1 |
| Burrows, GD | 1 |
| Vohra, J | 1 |
| Hunt, D | 1 |
| Sloman, JG | 1 |
| Scoggins, BA | 1 |
| Davies, B | 1 |
| Thompson, T | 1 |
| Pickens, R | 1 |
| Kehoe, WA | 1 |
| Kwentus, JA | 1 |
| Sheffel, WB | 1 |
| Harralson, AF | 1 |
| Good, MI | 1 |
| Brady, R | 1 |
| Lamb, RJ | 1 |
| Griffiths, RR | 1 |
| Tandon, R | 1 |
| Dutchak, D | 1 |
| Greden, JF | 1 |
| Yellowlees, PM | 1 |
| Preskorn, SH | 1 |
| Weller, EB | 1 |
| Hughes, CW | 1 |
| Weller, RA | 1 |
| Kranzler, HR | 1 |
| Hoffmeister, F | 1 |
| Goldberg, SR | 1 |
| Allen, JP | 1 |
| Denney, D | 1 |
| Kendall, JW | 1 |
| Blachly, PH | 1 |
| Wallace, JE | 1 |
| Blum, K | 1 |
| Singh, JM | 1 |
| Omenn, GS | 1 |
| Crowley, TJ | 1 |
| Kaneto, H | 1 |
| Koida, M | 1 |
| Tsuchie, F | 1 |
| Jatlow, P | 1 |
| Seligson, D | 1 |
| Crisp, AH | 1 |
| Baden, MM | 1 |
| Valanju, NN | 1 |
| Verma, SK | 1 |
| Valanju, SN | 1 |
| Rifkin, A | 1 |
| Kaplan, J | 1 |
| Oswald, I | 1 |
| Lewis, SA | 1 |
| Dunleavy, DL | 1 |
| Brezinova, V | 1 |
| Briggs, M | 1 |
| Schwartz, AS | 1 |
| Eidelberg, E | 1 |
| Voelkel, A | 1 |
| Milner, G | 1 |
| Porter, AM | 1 |
| Shatan, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized Controlled Trial of Electroconvulsive Therapy With Ketamine Anesthesia (Standard Therapy) and High Intensity Ketamine With Electroconvulsive Therapy Rescue for Treatment-Resistant Depression - EAST HIKER Trial[NCT03272698] | Phase 4 | 62 participants (Anticipated) | Interventional | 2017-09-01 | Recruiting | ||
| Subanesthetic Sevoflurane for Treatment-Resistant Depression: A Proof-of-Concept Trial[NCT05008939] | 15 participants (Anticipated) | Interventional | 2021-08-31 | Not yet recruiting | |||
| Computational Psychiatric Approach for Prognosis of Medication-Resistant Depression[NCT04189939] | 144 participants (Anticipated) | Observational | 2020-03-09 | Recruiting | |||
| Clinical Effects of Electroconvulsive Therapy in Severe Depression and Concomitant Changes in Cerebral Glucose Metabolism - an Exploratory Study[NCT01514435] | 13 participants (Actual) | Interventional | 2006-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for imipramine and Substance-Related Disorders
| Article | Year |
|---|---|
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods.
Topics: Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disorder, Major; Dose-Response Relationshi | 2007 |
Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression.
Topics: Alcoholism; Amitriptyline; Animals; Anxiety; Cardiovascular Diseases; Depression; Doxepin; Drug Inte | 1977 |
An experimental analysis of behavioral factors in drug dependence.
Topics: Administration, Oral; Alcoholism; Amphetamine; Animals; Behavior, Animal; Cannabis; Chlorpromazine; | 1975 |
Determination of drugs in biologic specimens--a review.
Topics: Amphetamine; Amphetamines; Autoanalysis; Barbiturates; Chemical Phenomena; Chemistry; Chromatography | 1974 |
Genetic issues in the syndrome of minimal brain dysfunction.
Topics: Attention Deficit Disorder with Hyperactivity; Dextroamphetamine; Diseases in Twins; Female; Humans; | 1973 |
2 trials available for imipramine and Substance-Related Disorders
| Article | Year |
|---|---|
Imipramine for the treatment of cocaine and methamphetamine dependence.
Topics: Cocaine; Combined Modality Therapy; Counseling; Dose-Response Relationship, Drug; Double-Blind Metho | 1994 |
Imipramine treatment of cocaine abuse: possible boundaries of efficacy.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Cocaine; Combined Modality Therapy; Comor | 1995 |
38 other studies available for imipramine and Substance-Related Disorders
| Article | Year |
|---|---|
Excess fatality from desipramine in children and adolescents.
Topics: Adolescent; Amitriptyline; Child; Desipramine; Doxepin; Humans; Imipramine; Incidence; Mortality; No | 2006 |
Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Aggression; Animals; Anti-Anxiety Age | 2008 |
3H-imipramine binding sites in platelets from psychiatric patients.
Topics: Antidepressive Agents; Binding, Competitive; Bipolar Disorder; Blood Platelets; Carrier Proteins; De | 1982 |
Delirium and stereotypy from anticholinergic antiparkinson drugs.
Topics: Adult; Aged; Benztropine; Delirium; Diazepam; Drug Therapy, Combination; Dyskinesia, Drug-Induced; E | 1982 |
The hyperactive child in adolescence: some pharmacologic approaches.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child Behavior Disorder | 1981 |
[The acute psychiatric emergency].
Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D | 1981 |
Adjunctive imipramine in substance-abusing dysphoric schizophrenic patients.
Topics: Adult; Female; Humans; Imipramine; Male; Schizophrenia; Substance-Related Disorders | 1993 |
Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects.
Topics: Administration, Oral; Animals; Autoradiography; Biological Transport; Brain; Carrier Proteins; Cocai | 1996 |
Pharmacotherapy of schizophrenia patients with comorbid substance abuse.
Topics: Alcoholism; Antipsychotic Agents; Cocaine; Flupenthixol; Humans; Imipramine; Marijuana Abuse; Opioid | 1997 |
The use of psychoactive drugs in the long-term treatment of chronic alcoholics.
Topics: Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Ch | 1975 |
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me | 1979 |
Enuresis treatment with imipramine hydrochloride: a 10-year follow-up study.
Topics: Adaptation, Psychological; Adolescent; Adult; Body Height; Body Weight; Child; Child Development; En | 1978 |
[2 unusual cases of psychotropic drug dependence (imipramine and reserpine)].
Topics: Adult; Female; Humans; Imipramine; Male; Middle Aged; Reserpine; Substance-Related Disorders | 1978 |
Tricyclic antidepressant overdoses in adolescent patients.
Topics: Adolescent; Affective Symptoms; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Dose-R | 1977 |
Monoamine oxidase inhibitors: potential for drug abuse.
Topics: Amphetamines; Drug Tolerance; Feeding Behavior; Humans; Imipramine; Male; Middle Aged; Monoamine Oxi | 1976 |
Cardiac effects of different tricyclic antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Bundle of His; Doxepin; Electrocardiograph | 1976 |
Increased alpha-1-acid glycoprotein in depression lowers free fraction of imipramine.
Topics: Acute-Phase Proteins; Adult; alpha-Macroglobulins; Depressive Disorder; Female; Hospitalization; Hum | 1991 |
Organic dissociative syndrome associated with antimigraine pharmacotherapy.
Topics: Adolescent; Analgesics; Aspirin; Barbiturates; Caffeine; Dissociative Disorders; Drug Combinations; | 1991 |
Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use.
Topics: Adult; Cocaine; Depressive Disorder; Drug Therapy, Combination; Female; Heroin Dependence; Humans; I | 1991 |
Self-administration in baboons and the discriminative stimulus effects in rats of bupropion, nomifensine, diclofensine and imipramine.
Topics: Animals; Antidepressive Agents; Bupropion; Conditioning, Operant; Discrimination, Psychological; Imi | 1990 |
Cholinergic syndrome following anticholinergic withdrawal in a schizophrenic patient abusing marijuana.
Topics: Adult; Benztropine; Brain; Humans; Imipramine; Male; Marijuana Abuse; Receptors, Cholinergic; Schizo | 1989 |
The treatment of psychiatric disorders in patients with chronic airways obstruction.
Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Depressive Disorder; Female; Humans; | 1987 |
Relationship of plasma imipramine levels to CNS toxicity in children.
Topics: Child; Delirium; Depressive Disorder; Female; Humans; Imipramine; Substance-Related Disorders | 1988 |
Secondary depression: treatment and outcome.
Topics: Alcoholism; Antidepressive Agents; Depressive Disorder; Drug Administration Schedule; Humans; Imipra | 1988 |
A comparison of chlorpromazine, imipramine, morphine and d-amphetamine self-administration in cocaine-dependent rhesus monkeys.
Topics: Animals; Behavior, Animal; Chlorpromazine; Cocaine; Dextroamphetamine; Dose-Response Relationship, D | 1973 |
Corticotropin release during ECT in man.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Anesthesia, General; Barbiturates; Colitis, Ulce | 1974 |
Dose-dependent facilitation or supression of rat fighting by methamphetamine, phenobarbital, or imipramine.
Topics: Aggression; Animals; Behavior, Animal; Depression, Chemical; Humans; Imipramine; Male; Methamphetami | 1972 |
[Tolerance and physical dependence producing liability of doxepin].
Topics: Amitriptyline; Animals; Body Weight; Diazepam; Dibenzoxepins; Drug Resistance; Humans; Imipramine; M | 1972 |
Application of a digital computer to emergency toxicology.
Topics: Barbiturates; Benzodiazepinones; Chromatography, Thin Layer; Clinical Laboratory Techniques; Colorim | 1974 |
Slow constant intravenous infusion of imipramine up to 850 mgm/day in patients with affective illness.
Topics: Blood; Depression; Female; Humans; Imipramine; Infusions, Parenteral; Substance Withdrawal Syndrome; | 1966 |
Confirmed identification of biotransformed drugs of abuse in urine.
Topics: Amphetamine; Analgesics; Barbiturates; Biotransformation; Caffeine; Cannabis; Chromatography, Gas; C | 1972 |
Phobic anxiety syndrome complicated by drug dependence and addiction. A treatable form of drug abuse.
Topics: Adult; Anxiety; Electroconvulsive Therapy; Ethanol; Evaluation Studies as Topic; Female; Hospitaliza | 1972 |
Drugs of dependence though not of abuse: fenfluramine and imipramine.
Topics: Adult; Appetite Depressants; Body Weight; Depression; Dreams; Female; Fenfluramine; Fluorine; Humans | 1971 |
Role of biogenic amines in morphine dependence in the rat.
Topics: Animals; Brain; Dihydroxyphenylalanine; Dopamine; Female; Humans; Imipramine; Male; Methyltyrosines; | 1970 |
[Complications caused by anonymous preclinical medication].
Topics: Amitriptyline; Antidepressive Agents; Barbiturates; Bromides; Cannabis; Chlordiazepoxide; Delirium; | 1970 |
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine | 1968 |
Drug defaulting in a general practice.
Topics: Anti-Bacterial Agents; Drug Therapy; Drug Utilization; Family Practice; Female; Fluorescence; Humans | 1969 |
Withdrawal symptoms after abrupt termination of imipramine.
Topics: Adult; Depression; Drug Tolerance; Humans; Imipramine; Male; Parent-Child Relations; Personality; Su | 1966 |