imipramine has been researched along with Sensitivity and Specificity in 28 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to estimate the cost effectiveness of nefazodone compared with imipramine or fluoxetine in treating women with major depressive disorder." | 3.69 | Modelling the cost effectiveness of antidepressant treatment in primary care. ( Anton, SF; Bakish, D; Brown, RE; Feeny, D; Palmer, W; Revicki, DA; Rosser, WW, 1995) |
| "Despite significant advances in the treatment of major depression, there is a high degree of variability in how patients respond to treatment." | 2.76 | Prognostic prediction of therapeutic response in depression using high-field MR imaging. ( Gong, Q; Huang, X; Jia, Z; Lui, S; Marquand, A; McGuire, P; Mechelli, A; Scarpazza, C; Wu, Q, 2011) |
| "The present study describes a new analytical approach for the detection and characterization of chemically reactive metabolites using glutathione ethyl ester (GSH-EE) as the trapping agent in combination with hybrid triple quadrupole linear ion trap mass spectrometry." | 1.35 | Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry. ( Fitch, WL; Wen, B, 2009) |
| " The time course and dose-response relationships for this effect were examined after treatment with two representative antidepressant drugs (imipramine and citalopram) and electriconvulsive shock (ECS)." | 1.29 | Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments. ( Layer, RT; Nowak, G; Paul, IA; Popik, P; Skolnick, P, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (50.00) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Vancea, S | 1 |
| Gáll, Z | 1 |
| Donáth-Nagy, G | 1 |
| Borka-Balás, R | 1 |
| Wen, B | 2 |
| Fitch, WL | 1 |
| Castagné, V | 1 |
| Porsolt, RD | 1 |
| Moser, P | 1 |
| Gong, Q | 1 |
| Wu, Q | 1 |
| Scarpazza, C | 1 |
| Lui, S | 1 |
| Jia, Z | 1 |
| Marquand, A | 1 |
| Huang, X | 1 |
| McGuire, P | 1 |
| Mechelli, A | 1 |
| Zhao, C | 1 |
| Wu, Z | 1 |
| Xue, G | 1 |
| Wang, J | 1 |
| Zhao, Y | 1 |
| Xu, Z | 1 |
| Lin, D | 1 |
| Herbert, G | 1 |
| Chang, Y | 1 |
| Cai, K | 1 |
| Xu, G | 1 |
| Takano, A | 1 |
| Suhara, T | 1 |
| Sudo, Y | 1 |
| Inoue, M | 1 |
| Hashimoto, K | 1 |
| Zhang, MR | 1 |
| Ichimiya, T | 1 |
| Yasuno, F | 1 |
| Suzuki, K | 1 |
| Bose, D | 1 |
| Martinavarro-Domínguez, A | 1 |
| Gil-Agustí, M | 1 |
| Carda-Broch, S | 1 |
| Durgbanshi, A | 1 |
| Capella-Peiró, ME | 1 |
| Esteve-Romero, J | 1 |
| O'Connor, D | 1 |
| Mortishire-Smith, R | 1 |
| Morrison, D | 1 |
| Davies, A | 1 |
| Dominguez, M | 1 |
| Cantú, MD | 1 |
| Toso, DR | 1 |
| Lacerda, CA | 1 |
| Lanças, FM | 1 |
| Carrilho, E | 1 |
| Queiroz, ME | 1 |
| Samanidou, VF | 1 |
| Nika, MK | 1 |
| Papadoyannis, IN | 1 |
| Ma, L | 1 |
| Nelson, SD | 1 |
| Zhu, M | 1 |
| Perry, PJ | 1 |
| Zeilmann, C | 1 |
| Arndt, S | 1 |
| Härtter, S | 1 |
| Hermes, B | 1 |
| Szegedi, A | 1 |
| Hiemke, C | 1 |
| Fujii, T | 1 |
| Kurihara, Y | 1 |
| Arimoto, H | 1 |
| Mitsutsuka, Y | 1 |
| Paul, IA | 1 |
| Nowak, G | 1 |
| Layer, RT | 1 |
| Popik, P | 1 |
| Skolnick, P | 1 |
| Koyama, E | 1 |
| Kikuchi, Y | 1 |
| Echizen, H | 1 |
| Chiba, K | 1 |
| Ishizaki, T | 1 |
| Adamczyk, M | 1 |
| Fishpaugh, J | 1 |
| Harrington, C | 1 |
| Johnson, D | 1 |
| Vanderbilt, A | 1 |
| Stangl, DK | 1 |
| Chen, AG | 1 |
| Wing, YK | 1 |
| Chiu, H | 1 |
| Lee, S | 1 |
| Chen, CN | 1 |
| Chan, K | 1 |
| Ishizuka, M | 1 |
| Yoshino, S | 1 |
| Yamamoto, Y | 1 |
| Yamamoto, H | 1 |
| Imaoka, S | 1 |
| Funae, Y | 1 |
| Masuda, M | 1 |
| Iwata, H | 1 |
| Kazusaka, A | 1 |
| Fujita, S | 1 |
| Aymard, G | 1 |
| Livi, P | 1 |
| Pham, YT | 1 |
| Diquet, B | 1 |
| Pommier, F | 1 |
| Sioufi, A | 1 |
| Godbillon, J | 1 |
| de la Torre, R | 1 |
| Ortuño, J | 1 |
| Pascual, JA | 1 |
| González, S | 1 |
| Ballesta, J | 1 |
| Revicki, DA | 1 |
| Brown, RE | 1 |
| Palmer, W | 1 |
| Bakish, D | 1 |
| Rosser, WW | 1 |
| Anton, SF | 1 |
| Feeny, D | 1 |
| Völp, A | 1 |
| Syed, AA | 1 |
| Khatoon, BA | 1 |
| Silwadi, MF | 1 |
| Krulík, R | 1 |
| Exner, J | 1 |
| Fuksová, K | 1 |
| Píchová, D | 1 |
| Beitlová, D | 1 |
| Sikora, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Intraoperative Low-dose Ketamine on Incidence of Postpartum Depression in Parturients With Prenatal Depression Undergoing Cesarean Delivery: Blind Test, Randomized, Placebo-controlled Trial[NCT03336541] | Phase 4 | 64 participants (Actual) | Interventional | 2017-11-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for imipramine and Sensitivity and Specificity
| Article | Year |
|---|---|
Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depres | 1994 |
2 trials available for imipramine and Sensitivity and Specificity
| Article | Year |
|---|---|
Prognostic prediction of therapeutic response in depression using high-field MR imaging.
Topics: Adult; Algorithms; Antidepressive Agents; Brain; Depression; Female; Humans; Image Enhancement; Imag | 2011 |
Comparative evaluation of two serotonin transporter ligands in the human brain: [(11)C](+)McN5652 and [(11)C]cyanoimipramine.
Topics: Adult; Brain; Carrier Proteins; Clomipramine; Humans; Imipramine; Injections, Intravenous; Isoquinol | 2002 |
25 other studies available for imipramine and Sensitivity and Specificity
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Rapid LC-MS/MS method for determination of drotaverine in a bioequivalence study.
Topics: Chromatography, Liquid; Humans; Imipramine; Methanol; Papaverine; Plasma; Reference Standards; Repro | 2014 |
Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry.
Topics: Acetaminophen; Amodiaquine; Carbamazepine; Glutathione; Humans; Imipramine; Mass Spectrometry; Metab | 2009 |
Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Fluoxetine; Imip | 2009 |
Ultra-high capacity liquid chromatography chip/quadrupole time-of-flight mass spectrometry for pharmaceutical analysis.
Topics: Animals; Capillary Electrochromatography; Chromatography, High Pressure Liquid; Imipramine; Mass Spe | 2011 |
Therapeutic monitoring of imipramine and desipramine by micellar liquid chromatography with direct injection and electrochemical detection.
Topics: Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Electrochemistry; Humans; Hyd | 2005 |
Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data.
Topics: Animals; Chromatography, High Pressure Liquid; Diazepam; Drug Evaluation, Preclinical; Drug Stabilit | 2006 |
Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Chromatography, Liq | 2006 |
Development of an HPLC method for the monitoring of tricyclic antidepressants in biofluids.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chemistry Techniques, Analytical; Chromatography, H | 2007 |
High-throughput screening and characterization of reactive metabolites using polarity switching of hybrid triple quadrupole linear ion trap mass spectrometry.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Clo | 2008 |
Automated determination of paroxetine and its main metabolite by column switching and on-line high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Drug | 1994 |
Surface ionization organic mass spectrometry of imipramine, desipramine, clomipramine, and lidocaine.
Topics: Clomipramine; Desipramine; Humans; Imipramine; Lidocaine; Mass Spectrometry; Sensitivity and Specifi | 1994 |
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Citalopram; Dose-Response Relationship, D | 1994 |
Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogeneti
Topics: Arylsulfatases; Calibration; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Electro | 1993 |
Immunoassay reagents for psychoactive drugs. II. The method for the development of antibodies specific to imipramine and desipramine.
Topics: Animals; Antibody Formation; Antibody Specificity; Antidepressive Agents, Tricyclic; Cross Reactions | 1993 |
Prediction and decision making using Bayesian hierarchical models.
Topics: Antidepressive Agents, Tricyclic; Bayes Theorem; Cost-Benefit Analysis; Decision Making; Depressive | 1995 |
Simultaneous determination of imipramine, desipramine and their 2- and 10-hydroxylated metabolites in human plasma and urine by high-performance liquid chromatography.
Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Female; | 1997 |
Isozyme selective alterations of the expression of cytochrome P450 during regeneration of male rat liver following partial hepatectomy.
Topics: Androstenedione; Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Female; Hepatectomy; Im | 1997 |
Sensitive and rapid method for the simultaneous quantification of five antidepressants with their respective metabolites in plasma using high-performance liquid chromatography with diode-array detection.
Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Chromatog | 1997 |
Simultaneous determination of imipramine and its metabolite desipramine in human plasma by capillary gas chromatography with mass-selective detection.
Topics: Administration, Oral; Antidepressive Agents, Tricyclic; Calibration; Chromatography, Gas; Circadian | 1997 |
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Dru | 1998 |
Modelling the cost effectiveness of antidepressant treatment in primary care.
Topics: Antidepressive Agents; Decision Support Techniques; Depressive Disorder; Female; Fluoxetine; Humans; | 1995 |
Comparison of St John's Wort and imipramine. Sensitivity of assay is questionable.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Hypericum; Imipramine; Phytotherapy; | 2001 |
New reagents for detection of faecal occult blood.
Topics: Alkanes; Desipramine; Edetic Acid; Humans; Hydrogen-Ion Concentration; Imipramine; Indicators and Re | 2001 |
Radioimmunoassay of dibenzazepines and dibenzcycloheptanodienes in body fluids and tissues.
Topics: Amitriptyline; Erythrocyte Membrane; Humans; Imipramine; Ligands; Radioimmunoassay; Reproducibility | 1991 |