Page last updated: 2024-10-29

imipramine and Seizures

imipramine has been researched along with Seizures in 95 studies

Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"The present study was undertaken to get insight in the possible mechanisms of imipramine-induced seizures in amygdala-kindled rats."7.73Mechanism of imipramine-induced seizures in amygdala-kindled rats. ( Ago, J; Ashequr Rahman, M; Ishikawa, T; Kamei, C; Matsumoto, N, 2006)
" The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice."7.69Strychnine-induced seizures in mice: the role of noradrenaline. ( Amabeoku, G; Chandomba, R, 1994)
"The effects of some noradrenergic agents, phenobarbitone, diazepam and phenytoin on seizures produced by propranolol were investigated in mice."7.69Propranolol-induced seizures in mice: the role of noradrenaline. ( Amabeoku, GJ; Syce, JA, 1997)
"The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice."7.68The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993)
"The incidence of convulsions in patients receiving tricyclic antidepressants or bupropion was reviewed."6.36Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion. ( Peck, AW; Stern, WC; Watkinson, C, 1983)
"The present study was undertaken to get insight in the possible mechanisms of imipramine-induced seizures in amygdala-kindled rats."3.73Mechanism of imipramine-induced seizures in amygdala-kindled rats. ( Ago, J; Ashequr Rahman, M; Ishikawa, T; Kamei, C; Matsumoto, N, 2006)
" The effects of some noradrenergic agents on seizures induced by strychnine were investigated in mice."3.69Strychnine-induced seizures in mice: the role of noradrenaline. ( Amabeoku, G; Chandomba, R, 1994)
"The effects of some noradrenergic agents, phenobarbitone, diazepam and phenytoin on seizures produced by propranolol were investigated in mice."3.69Propranolol-induced seizures in mice: the role of noradrenaline. ( Amabeoku, GJ; Syce, JA, 1997)
"The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice."3.68The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993)
"Enuresis is a common problem often treated effectively with imipramine hydrochloride."3.66Treatment of imipramine overdose in children. ( Cromie, WJ; Greene, AS, 1981)
"The role of brain monoamines in the anticonvulsant effect of imipramine was investigated in albino rats, against maximal electroshock-induced seizures, by using drugs with well-defined effects on brain monoamines."3.65Role of brain monoamines in the anticonvulsant effect of imipramine in albino rats. ( Bhattacharya, SK; Das, PK; Mukhopadhyay, SN; Reddy, PK, 1976)
"Assessment of seizure risk in individuals involves consideration of predisposing factors, the antidepressant selected, and the bioavailability of the drug."2.38Seizures associated with antidepressants: a review. ( Jacobs, SC; Nelson, JC; Rosenstein, DL, 1993)
"The incidence of convulsions in patients receiving tricyclic antidepressants or bupropion was reviewed."2.36Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion. ( Peck, AW; Stern, WC; Watkinson, C, 1983)
" Finally, chronic administration of imipramine significantly increased mBDNF levels, but not pro-BDNF and protease levels, indicating that the therapeutic mechanism of imipramine differs from that of ECS."1.39Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus. ( Fuchikami, M; Matsumoto, T; Morinobu, S; Segawa, M; Yamawaki, S, 2013)
"On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)."1.27Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984)
"Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants."1.27Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex. ( Ikeda, M; Knapp, RJ; Malatynska, E; Yamamura, HI, 1988)
"Fengabine (SL 79."1.27Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. ( Bartholini, G; Depoortere, H; Lloyd, KG; Sanger, D; Zivkovic, B, 1987)
"According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony."1.27Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985)
" Chronic administration of antidepressant drugs: amitriptyline, imipramine and zimelidine augmented the PDC."1.26Postdecapitation convulsions in the rat measured with an Animex motility meter: relation to central alpha-adrenoceptors. ( Pilc, A; Vetulani, J, 1982)
"Generalised seizures were seen 15-30 min after imipramine or chlorimipramine (20 mg/kg), and these two drugs showed no difference in their epileptogenicity."1.26Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms. ( Anlezark, G; Meldrum, B; Trimble, M, 1977)
" It is concluded that all four drugs show the toxic effects classically associated with tricyclic antidepressants but the relative toxicity amongst these agents varies considerably and is in the order amitriptyline greater than imipramine greater than maprotiline greater than mianserin."1.26The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo. ( Hughes, IE; Radwan, S, 1979)
"could increase the risk of seizures."1.26[Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents]. ( Escande, M; Gayral, L; Golberger, E; Jarrige, A; Kulik, J, 1976)
" Increasing doses of nortriptyline produced a parallel shift of the hypothermic log dose-response curve for intraventricular injections of noradnamine to the right."1.25The interactions of noradnamine and imipramine-like antidepressant drugs. ( Cowell, P, 1969)

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-199079 (83.16)18.7374
1990's11 (11.58)18.2507
2000's2 (2.11)29.6817
2010's3 (3.16)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abdel-Aziz, M1
Abuo-Rahma, Gel-D1
Hassan, AA1
Gunia-Krzyżak, A1
Żelaszczyk, D1
Rapacz, A1
Żesławska, E1
Waszkielewicz, AM1
Pańczyk, K1
Słoczyńska, K1
Pękala, E1
Nitek, W1
Filipek, B1
Marona, H1
Saitoh, A1
Sugiyama, A1
Nemoto, T1
Fujii, H1
Wada, K1
Oka, J1
Nagase, H1
Yamada, M1
Segawa, M1
Morinobu, S1
Matsumoto, T1
Fuchikami, M1
Yamawaki, S1
BARUK, H1
LAUNAY, J1
GESENSWAY, D1
COHEN, KD1
CORRIOL, J1
ZWIRN, P1
KURIHARA, M1
PLOTNIKOFF, NP1
PLOTNIKOFF, N1
KEITH, J1
HEIMANN, M1
KEITH, W1
PERRY, C1
CASTAING, R1
BOUREOSI, M1
CHEVAIS, R1
GILLARDEAU, G1
FAVAREL-GARRIGUES, JC1
CARDINAUD, JP1
JOHNSON, MH1
BOUCHER, JV1
JORGENSEN, F1
MONTANARO, N1
BABBINI, M1
CASOLI, R1
PROUT, BJ1
YOUNG, J1
GODDARD, P1
CHEIKHZADEH, A1
SCHOLER, H1
STILLE, G1
SAYERS, A1
Ago, J1
Ishikawa, T1
Matsumoto, N1
Ashequr Rahman, M1
Kamei, C1
Dalessio, DJ1
Lehmann, A1
Steel, CM1
O'Duffy, J1
Brown, SS1
Gupta, ML1
Gupta, TK1
Bhargava, KP1
Vetulani, J1
Pilc, A1
Simon, P2
Greene, AS1
Cromie, WJ1
Peck, AW1
Stern, WC1
Watkinson, C1
Krijzer, F1
Snelder, M1
Bradford, D1
Olczak, S1
Lapin, IP2
Lowry, MR1
Dunner, FJ1
Sener, EK1
Gabe, S1
Henry, JA1
Amabeoku, G1
Chandomba, R1
Amabeoku, GJ2
Rosenstein, DL1
Nelson, JC1
Jacobs, SC1
Abel, EL2
Hamed, M1
Mitchell, H1
Clow, DJ1
Syce, JA1
Almeida, RN1
Navarro, DS1
de Assis, TS1
de Medeiros, IA1
Thomas, G1
Georgiev, VP1
Petkova, BP1
Bhattacharya, SK1
Mukhopadhyay, SN1
Reddy, PK1
Das, PK1
Trimble, M2
Anlezark, G2
Meldrum, B1
Koella, WP1
Glatt, A1
Klebs, K1
Dürst, T1
Reed, K1
McKim, HR1
Sato, M1
Hikasa, N1
Otsuki, S1
Hughes, IE1
Radwan, S1
Escande, M1
Gayral, L1
Golberger, E1
Jarrige, A1
Kulik, J1
Trimble, MR1
Meldrum, BS1
Carpenter, DC1
Beaubien, AR1
Mathieu, LF1
Hrdina, PD1
Sheinbein, ML1
Wiggins, KM1
Maj, J1
Rogóz, Z1
Skuza, G1
Sowińska, H1
Bilitzke, PJ1
Cotton, DB1
Kleinrok, Z1
Gustaw, J1
Czuczwar, SJ1
Malatynska, E1
Knapp, RJ1
Ikeda, M1
Yamamura, HI1
Escorihuela, RM1
Boix, F1
Corda, MG1
Tobeña, A1
Fernández Teruel, A1
Tribble, J1
Weinhouse, E1
Garland, J1
Wendelberger, K1
Lloyd, KG1
Zivkovic, B1
Sanger, D1
Depoortere, H1
Bartholini, G1
Dailey, JW1
Jobe, PC2
Rasmussen, J1
Wallach, MB2
Winters, WD2
Mandell, AJ3
Spooner, CE2
Baltzer, V1
Bein, HJ1
Shimizu, M1
Hirooka, T1
Karasawa, T1
Masuda, Y1
Oka, M1
Mennear, JH1
Rudzik, AD1
Boissier, JR1
Villeneuve, A1
Larousse, C1
Zelikman, TIa1
Shekhtman, ML1
Kita, T1
Hata, T1
Murakami, T1
Srimal, RC1
Singh, HK1
Dhawan, BN1
Brown, KG1
McMichen, HU1
Briggs, DS1
Parkin, JM1
Fraser, MS1
Knapp, S1
Kuczenski, RT1
Segal, DS1
Westheimer, R1
Klawans, HL1
Eggermont, E1
Raveschot, J1
Deneve, V1
Casteels-van Daele, M1
Ueki, S1
Ogawa, N1
Watanabe, S1
Gomita, Y1
Araki, Y1
Brown, D1
Winsberg, BG1
Bialer, I1
Press, M1
Picchioni, AL1
Chin, L1
Filias, N1
Jornod, J1
Sedal, L1
Korman, MG1
Williams, PO1
Mushin, G1
Nakanishi, M1
Tsumagari, T1
Nakanishi, A1
Brown, TC1
Dwyer, ME1
Stocks, JG1
De Carolis, AS1
Ziegler, H1
Del Basso, P1
Longo, VG1
Bauditz, W2
Bartelheimer, HK2
Lund-Larsen, G1
Silvertssen, E1
Allikmets, LH1
Vahing, VA1
Bonvini, E1
Valente, G1
Noto, R1
Robert, J1
Hanote, P1
Dobrescu, D1
Coeugniet, E1
Schuckit, M1
Robins, E1
Feighner, J1
Cowell, P1
Burger, A1
Siuda, JF1
Suchowsky, GK1
Pegrassi, L1
Bonsignori, A1
Bertazzoli, C1
Chieli, T1
Vest, M1
Hirt, HR1
Olafsson, A1
Girard, J1
Ringel, J1
Edwards, J1

Reviews

3 reviews available for imipramine and Seizures

ArticleYear
Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion.
    The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5 Pt 2

    Topics: Antidepressive Agents; Bupropion; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Imi

1983
Seizures associated with antidepressants: a review.
    The Journal of clinical psychiatry, 1993, Volume: 54, Issue:8

    Topics: Antidepressive Agents; Biological Availability; Causality; Depressive Disorder; Dose-Response Relati

1993
Non-monoamine oxidase inhibitor antidepressants and epilepsy: a review.
    Epilepsia, 1978, Volume: 19, Issue:3

    Topics: Adult; Aged; Amines; Animals; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricycl

1978

Other Studies

92 other studies available for imipramine and Seizures

ArticleYear
Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Hindlimb Suspension; Mice; Pyrazo

2009
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo

2017
The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions.
    Behavioural brain research, 2011, Oct-01, Volume: 223, Issue:2

    Topics: Analgesics; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Benz

2011
Electroconvulsive seizure, but not imipramine, rapidly up-regulates pro-BDNF and t-PA, leading to mature BDNF production, in the rat hippocampus.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:2

    Topics: Animals; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Disease Models, Animal

2013
[Excitant and convulsive effects of imipramine (G. 22355) on monkeys].
    Annales medico-psychologiques, 1959, Volume: 117, Issue:1

    Topics: Acridines; Animals; Brain; Haplorhini; Humans; Imipramine; Seizures

1959
Report of a case of convulsion and skin reaction following brief oral administration of imipramine (tofranil).
    The American journal of psychiatry, 1960, Volume: 116

    Topics: Administration, Oral; Imipramine; Psychopharmacology; Seizures; Skin Diseases

1960
[Does RP 7162 (Surmontyl) possess a convulsive action?].
    Marseille medical, 1962, Volume: 99

    Topics: Epilepsy; Humans; Imipramine; Seizures

1962
[SOME PHARMACOLOGICAL EXPERIMENTS ON ANTIDEPRESSANTS--IN REFERENCE TO CEREBRAL MONOAMINES].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1963, Volume: 65

    Topics: 5-Hydroxytryptophan; Antidepressive Agents; Bemegride; Dihydroxyphenylalanine; Eyelids; Fever; Imipr

1963
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
    Archives internationales de pharmacodynamie et de therapie, 1963, Oct-01, Volume: 145

    Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacol

1963
STIMULANT EFFECTS OF TETRAHYDROCYCLOHEPTAQUINOLINE DERIVATIVES.
    Archives internationales de pharmacodynamie et de therapie, 1963, Dec-01, Volume: 146

    Topics: Acridines; Amphetamine; Amphetamines; Barbiturates; Behavior, Animal; Blood Pressure; Blood Pressure

1963
[ACUTE POISONINGS BY IMIPRAMINE. (9 CASES TREATED AT THE CENTRE DE R'EANIMATION RESPIRATOIRE)].
    Journal de medecine de Bordeaux et du Sud-Ouest, 1964, Volume: 141

    Topics: Child; Coma; Electrocardiography; Electroencephalography; Humans; Imipramine; Mental Disorders; Seiz

1964
A FATALITY ASSOCIATED WITH ANTIDEPRESSANT THERAPY.
    The American journal of psychiatry, 1964, Volume: 120

    Topics: Antidepressive Agents; Black People; Geriatrics; Humans; Imipramine; Psychotherapy; Seizures; Spasm;

1964
[IMIPRAMINE POISONING].
    Ugeskrift for laeger, 1964, Apr-23, Volume: 126

    Topics: Adolescent; Antidepressive Agents; Coma; Depression; Depressive Disorder; Geriatrics; Imipramine; Mu

1964
[AUDIOGENIC SEIZURES IN THE ALBINO RAT AS A TEST IN THE STUDY OF DRUGS INTERACTING WITH CEREBRAL BIOGENETIC AMINES].
    Archivio italiano di scienze farmacologiche, 1963, Volume: 13

    Topics: Amines; Biological Assay; Central Nervous System; Epilepsy, Reflex; Imipramine; Pharmacology; Rats;

1963
IMIPRAMINE POISONING IN CHILDHOOD AND SUGGESTED TREATMENT.
    British medical journal, 1965, Apr-10, Volume: 1, Issue:5440

    Topics: Antidepressive Agents; Coma; Diuresis; Electrocardiography; Gastric Lavage; Glucose; Heart Arrest; H

1965
[THE SYMPTOMATIC PICTURE OF IMIPRAMINE TOXICOLOGY (TOFRANIL)].
    Helvetica medica acta, 1964, Volume: 31

    Topics: Adolescent; Arrhythmias, Cardiac; Child; Coma; Diagnosis; Heart Block; Humans; Imipramine; Neurologi

1964
THE EFFECT OF ANTIDEPRESSANT DRUGS ON THE CONVULSIVE EXCITABILITY OF BRAIN STRUCTURES.
    International journal of neuropharmacology, 1964, Volume: 3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Caudate Nucleus; Cerebral Cortex; Electric Stimulatio

1964
Mechanism of imipramine-induced seizures in amygdala-kindled rats.
    Epilepsy research, 2006, Volume: 72, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Behavior, Animal; Convulsants;

2006
Chronic pain syndromes and disordered cortical inhibition: effects of tricyclic compounds.
    Diseases of the nervous system, 1967, Volume: 28, Issue:5

    Topics: Amitriptyline; Animals; Anticonvulsants; Cerebral Cortex; Humans; Imipramine; Mice; Pain; Paresthesi

1967
Audiogenic seizures data in mice supporting new theories of biogenic amines mechanisms in the central nervous system.
    Life sciences, 1967, Jul-01, Volume: 6, Issue:13

    Topics: Amitriptyline; Animals; Brain; Hormones; Imipramine; Indoles; Isocarboxazid; Mice; Nialamide; Norepi

1967
Clinical effects and treatment of imipramine and amitriptyline poisoning in children.
    British medical journal, 1967, Sep-09, Volume: 3, Issue:5566

    Topics: Accident Prevention; Amitriptyline; Blood Gas Analysis; Child; Chlorpromazine; Electrocardiography;

1967
Central anticholinergic activity of imipramine and allied drugs.
    Canadian journal of physiology and pharmacology, 1967, Volume: 45, Issue:2

    Topics: Amitriptyline; Animals; Atropine; Carbachol; Desipramine; Female; Imipramine; Male; Mice; Parasympat

1967
Postdecapitation convulsions in the rat measured with an Animex motility meter: relation to central alpha-adrenoceptors.
    European journal of pharmacology, 1982, Dec-03, Volume: 85, Issue:3-4

    Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Brain; Imipramine; Male; Prazosin; Rat

1982
Antidepressants, benzodiazepines, and convulsions.
    Biological psychiatry, 1983, Volume: 18, Issue:4

    Topics: Adult; Anti-Anxiety Agents; Clorazepate Dipotassium; Female; Humans; Imipramine; Seizures; Substance

1983
Treatment of imipramine overdose in children.
    Urology, 1981, Volume: 18, Issue:3

    Topics: Adult; Arrhythmias, Cardiac; Bicarbonates; Child; Child, Preschool; Coma; Diazepam; Drug Administrat

1981
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
    Neuropsychobiology, 1984, Volume: 12, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re

1984
Tricyclic antidepressant poisoning and prolonged external cardiac massage during asystole.
    British medical journal (Clinical research ed.), 1981, Dec-05, Volume: 283, Issue:6305

    Topics: Humans; Imipramine; Phenytoin; Seizures

1981
Kynurenines and audiogenic excitement in mice.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:1

    Topics: Acoustic Stimulation; Animals; Body Temperature; Female; Haloperidol; Imipramine; Injections, Intrap

1980
Seizures during tricyclic therapy.
    The American journal of psychiatry, 1980, Volume: 137, Issue:11

    Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Electroencephalography; Epilepsy; Femal

1980
Response to glucagon in imipramine overdose.
    Journal of toxicology. Clinical toxicology, 1995, Volume: 33, Issue:1

    Topics: Adult; Diazepam; Drug Overdose; Electrocardiography; Female; Glucagon; Humans; Imipramine; Infusions

1995
Strychnine-induced seizures in mice: the role of noradrenaline.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:4

    Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Disulfiram; Droxidopa; Idazoxan; Imipram

1994
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
    Experientia, 1993, Oct-15, Volume: 49, Issue:10

    Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Dr

1993
Strain differences in convulsions induced by alarm substance.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:3

    Topics: Animals; Imipramine; Immobilization; Male; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wist

1993
Hyponatraemic convulsion associated with desmopressin and imipramine treatment.
    BMJ (Clinical research ed.), 1993, May-01, Volume: 306, Issue:6886

    Topics: Child; Deamino Arginine Vasopressin; Humans; Hyponatremia; Imipramine; Male; Seizures

1993
Propranolol-induced seizures in mice: the role of noradrenaline.
    Cellular and molecular life sciences : CMLS, 1997, Volume: 53, Issue:8

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic Uptake Inhibitors; alpha-Methyltyros

1997
Antidepressant effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice.
    Journal of ethnopharmacology, 1998, Volume: 63, Issue:3

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Blepharoptosis;

1998
The effect of p-bromomethamphetamine (V-111), a selective serotoninergic amphetamine, on the convulsive seizure excitability threshold in mice.
    Neuropharmacology, 1976, Volume: 15, Issue:12

    Topics: 5-Hydroxytryptophan; Animals; Fenclonine; Imipramine; Male; Methamphetamine; Mice; Nialamide; Pentyl

1976
Role of brain monoamines in the anticonvulsant effect of imipramine in albino rats.
    Pharmacology, 1976, Volume: 14, Issue:5

    Topics: Animals; Anticonvulsants; Apomorphine; Catecholamines; Ditiocarb; Dopamine; Drug Interactions; Elect

1976
Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms.
    Psychopharmacology, 1977, Jan-31, Volume: 51, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Electroencephal

1977
Epileptic phenomena induced in the cat by the antidepressants maprotiline, imipramine, clomipramine, and amitriptyline.
    Biological psychiatry, 1979, Volume: 14, Issue:3

    Topics: Amitriptyline; Animals; Anthracenes; Cats; Cerebral Cortex; Clomipramine; Electroencephalography; Ev

1979
ECG changes in pure impramine overdose as function of plasma level.
    Canadian Psychiatric Association journal, 1978, Volume: 23, Issue:8

    Topics: Adult; Desipramine; Electrocardiography; Female; Heart; Heart Arrest; Heart Conduction System; Human

1978
[Effects of nomifensine and imipramine on amygdaloid kindled convulsion--inhibitory effects of dopamine on epileptic seizure (author's transl)].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1978, Volume: 80, Issue:7

    Topics: Amygdala; Animals; Cats; Dopamine; Electric Stimulation; Imipramine; Isoquinolines; Nomifensine; Sei

1978
The relative toxicity of amitriptyline, imipramine, maprotiline and mianserin in rabbits in vivo.
    British journal of pharmacology, 1979, Volume: 65, Issue:2

    Topics: Amitriptyline; Anesthesia; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Behavior

1979
[Convulsive incidents and EEG changes during treatment with tricyclic antidepressive agents].
    L'Encephale, 1976, Volume: 2, Issue:2

    Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clomipramine; Electroencephalography;

1976
Effect of nomifensine on brain amines and epilepsy in photosensitive baboons.
    British journal of clinical pharmacology, 1977, Volume: 4Suppl 2

    Topics: Amines; Animals; Brain Chemistry; Clomipramine; Dose-Response Relationship, Drug; Imipramine; Isoqui

1977
Letter: Amitriptyline and imipramine poisoning in children.
    British medical journal, 1975, Mar-01, Volume: 1, Issue:5956

    Topics: Amitriptyline; Animals; Antidotes; Humans; Imipramine; Phenytoin; Poisoning; Rats; Seizures

1975
An operant counting scale for children: A preliminary methodological psychoactive-drug case study.
    Child psychiatry and human development, 1975,Spring, Volume: 5, Issue:3

    Topics: Adolescent; Aggression; Anxiety Disorders; Child; Child Behavior Disorders; Dependency, Psychologica

1975
The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist.
    Neuropharmacology, 1992, Volume: 31, Issue:7

    Topics: Animals; Antidepressive Agents; Benzazepines; Citalopram; Dizocilpine Maleate; Fluoxetine; Imipramin

1992
Alarm substance induces convulsions in imipramine-treated rats.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:3

    Topics: Adrenal Glands; Adrenalectomy; Animals; Behavior, Animal; Imipramine; Male; Pheromones; Rats; Rats,

1992
Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valproate in mice.
    Journal of neural transmission. Supplementum, 1991, Volume: 34

    Topics: Amitriptyline; Animals; Desipramine; Dose-Response Relationship, Drug; Electroshock; Imipramine; Mal

1991
Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.
    Life sciences, 1988, Volume: 43, Issue:4

    Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chlorides; Desipramine; gamma-Aminob

1988
Chronic but not acute antidepressant treatment increases pentetrazol-induced convulsions in mice.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:2

    Topics: Animals; Antidepressive Agents; Desipramine; Drug Synergism; Imipramine; Male; Mice; Mice, Inbred St

1989
Treatment of severe imipramine poisoning complicated by a negative history of drug ingestion.
    Pediatric emergency care, 1989, Volume: 5, Issue:4

    Topics: Acute Disease; Desipramine; Electrocardiography; Emergencies; Female; Gastric Lavage; Humans; Imipra

1989
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bicuculline; Chlorophenols; Cl

1987
Anticonvulsant drugs and the genetically epilepsy-prone rat.
    Federation proceedings, 1985, Volume: 44, Issue:10

    Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M

1985
Amitriptyline and imipramine poisoning.
    Lancet (London, England), 1965, Oct-23, Volume: 2, Issue:7417

    Topics: Adult; Amitriptyline; Humans; Imipramine; Male; Neurologic Manifestations; Phenobarbital; Seizures

1965
A correlation of EEG, reticular multiple unit activity and gross behavior following various antidepressant agents in the cat. IV.
    Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:6

    Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Cats; Chlorpromazine; Desipramine;

1969
Pharmacological investigations with benzoctamine (Tacitin), a new psycho-active agent.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 201, Issue:1

    Topics: Adjuvants, Anesthesia; Aggression; Animals; Anthracenes; Cats; Central Nervous System; Chlordiazepox

1973
Pharmacological evaluation of 3-(N-3,3-diphenylpropyl-N-methyl)-aminopropan-1-ol-hydrochloride (PF-82), a new type of antidepressant drug.
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Cats; Chick Embryo; Dogs; Drug Antagonism; Drug Evalu

1974
Potentiation of the anticonvulsant action of acetazolamide.
    The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:12

    Topics: Acetazolamide; Amphetamine; Animals; Anticonvulsants; Caffeine; Cocaine; Desipramine; Drug Synergism

1966
Flurothyl in mice: seizure, post-convulsive behavior, and interactions with psychotropic drugs.
    Canadian journal of physiology and pharmacology, 1968, Volume: 46, Issue:1

    Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Biperiden; Caffeine; Catalepsy; Central Nervous Sy

1968
[On the clinical course and therapy of pathological conditions caused by incompatible antidepressants].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1968, Volume: 68, Issue:1

    Topics: Adult; Anuria; Bipolar Disorder; Bis-Trimethylammonium Compounds; Depression; Depressive Disorder, M

1968
[Introduction of mass psychology in animals to pharmacology. 6. Mutural relation in simultaneity convulsion and non-convulsin in E1-mice].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1970, Jul-20, Volume: 66, Issue:4

    Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Camphor; Central Nervous Sy

1970
Experimental evidence for imipramine like activity of fenfluramine.
    Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 188, Issue:2

    Topics: Animals; Avoidance Learning; Blepharoptosis; Blood Pressure; Body Temperature; Cats; Columbidae; Dru

1970
Tachyarrhythmia in severe imipramine overdose controlled by practolol.
    Archives of disease in childhood, 1972, Volume: 47, Issue:251

    Topics: Adrenergic beta-Antagonists; Child, Preschool; Coma; Electrocardiography; Heart Arrest; Humans; Imip

1972
Poisoning as a complication of enuresis.
    Developmental medicine and child neurology, 1972, Volume: 14, Issue:6

    Topics: Amitriptyline; Antidepressive Agents; Child, Preschool; Enuresis; Humans; Imipramine; Ipecac; Nortri

1972
Methamphetamine-induced alteration in the physical state of rat caudate tyrosine hydroxylase.
    Biochemical pharmacology, 1972, Oct-15, Volume: 21, Issue:20

    Topics: Animals; Caudate Nucleus; Colchicine; Cycloheximide; Dialysis; Dose-Response Relationship, Drug; Ele

1972
The role of serotonin in the pathophysiology of myoclonic seizures associated with acute imipramine toxicity.
    Neurology, 1974, Volume: 24, Issue:12

    Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Brain Chemistry; Drug Synergism; Guinea Pigs;

1974
The adverse influence of imipramine on the adaptation of the newborn infant to extrauterine life.
    Acta paediatrica Belgica, 1972, Volume: 26, Issue:4

    Topics: Cyanosis; Depression; Female; Fetal Diseases; Fetus; Heart Failure; Humans; Imipramine; Infant, Newb

1972
[Psychopharmacological effects of doxepin hydrochloride].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:6

    Topics: Amitriptyline; Amphetamine; Animals; Behavior, Animal; Blepharoptosis; Body Temperature; Brain Chemi

1972
Imipramine therapy and seizures: three children treated for hyperactive behavior disorders.
    The American journal of psychiatry, 1973, Volume: 130, Issue:2

    Topics: Aggression; Brain Damage, Chronic; Child; Child Behavior Disorders; Child, Preschool; Dose-Response

1973
Role of brain norepinephrine in audiogenic seizure in the rat.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 184, Issue:1

    Topics: Animals; Brain Chemistry; Cold Temperature; Dopamine; Female; Histocytochemistry; Imipramine; Methyl

1973
[Cardiovascular complications of tricyclic anti-depressants. Apropos of a case of acute poisoning].
    Revue medicale de la Suisse romande, 1973, Volume: 93, Issue:12

    Topics: Adult; Arrhythmias, Cardiac; Bundle-Branch Block; Diazepam; Digitalis Glycosides; Electrocardiograph

1973
Overdosage of tricyclic antidepressants. A report of two deaths and a prospective study of 24 patients.
    The Medical journal of Australia, 1972, Jul-08, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Bundle-Branch Block;

1972
Studies on psychotropic drugs. XI. Pharmacology of 3-chloro-5-(3-(4-piperidino-4-carbamoyl-piperidino)-propyl)-10,11-dihydro-(5H)-dibenz-(b,f)-azepine dihydrochloride monohydrate.
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:3

    Topics: Animals; Avoidance Learning; Chemical Phenomena; Chemistry; Chlorpromazine; Conditioning, Classical;

1971
Antidepressant overdosage in children--a new menace.
    The Medical journal of Australia, 1971, Oct-23, Volume: 2, Issue:17

    Topics: Accidents, Home; Adolescent; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Child; Chil

1971
Central effects of 6-hydroxydopamine.
    Physiology & behavior, 1971, Volume: 7, Issue:5

    Topics: Amantadine; Amitriptyline; Amphetamine; Animals; Behavior, Animal; Brain; Brain Chemistry; Desiprami

1971
[Hemodialysis treatment of a 3 1-4-year-old child with imipramine poisoning].
    Archiv fur Toxikologie, 1970, Volume: 26, Issue:2

    Topics: Arrhythmias, Cardiac; Charcoal; Child, Preschool; Chloral Hydrate; Electrocardiography; Electroencep

1970
[Imipramine cardiopathy].
    Nordisk medicin, 1968, Volume: 80, Issue:30

    Topics: Adult; Coma; Electric Stimulation Therapy; Electrocardiography; Female; Heart Ventricles; Humans; Hy

1968
Dissimilar influences of imipramine, benactyzine and promazine on effects of micro-injections of noradrenaline, acetylcholine and serotonin into the amygdala in the cat.
    Psychopharmacologia, 1969, Volume: 15, Issue:5

    Topics: Acetylcholine; Aggression; Amygdala; Animals; Attention; Behavior, Animal; Benactyzine; Cats; Electr

1969
[Acute imipramine poisoning in a 2-year-old girl].
    Minerva pediatrica, 1969, Jul-28, Volume: 21, Issue:30

    Topics: Acute Disease; Child, Preschool; Coma; Female; Humans; Imipramine; Seizures

1969
[Treatment of imipramine poisoning at childhood].
    Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:11

    Topics: Arrhythmias, Cardiac; Carbon; Child, Preschool; Chloral Hydrate; Coma; Gastric Lavage; Humans; Hypot

1970
[Emergency treatment and transportation of cases of acute imipramine derivative poisoning (apropos of 70 cases)].
    Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1970, Volume: 11, Issue:6

    Topics: Arrhythmias, Cardiac; Barbiturates; Cardiovascular Diseases; Electrocardiography; First Aid; Humans;

1970
[Anticonvulsant action of imipramine and imitriptyline associated with phenobarbital, phenytoin and diazepam].
    Revue neurologique, 1970, Volume: 123, Issue:2

    Topics: Amitriptyline; Animals; Anticonvulsants; Diazepam; Electroshock; Imipramine; Mice; Pentylenetetrazol

1970
Tricyclic antidepressants and monoamine oxidase inhibitors.
    Archives of general psychiatry, 1971, Volume: 24, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug

1971
A neuropharmacological comparison of some tricyclic anti-depressant agents.
    Proceedings of the Western Pharmacology Society, 1968, Volume: 11

    Topics: Amitriptyline; Animals; Behavior, Animal; Cats; Electroencephalography; Imipramine; Seizures; Sleep;

1968
The interactions of noradnamine and imipramine-like antidepressant drugs.
    British journal of pharmacology, 1969, Volume: 36, Issue:1

    Topics: Animals; Antidepressive Agents; Brain Chemistry; Cerebral Ventricles; Dibenzocycloheptenes; Hypother

1969
o,o'-Disubstituted phenylcyclopropylamines.
    Journal of medicinal chemistry, 1969, Volume: 12, Issue:2

    Topics: Amphetamine; Animals; Blepharoptosis; Hexobarbital; Imipramine; Mice; Motor Activity; Propylamines;

1969
Some pharmacological properties of 4H-3-methylcarboxamide 1,3-benzoxazine-2-one (FI 6654).
    European journal of pharmacology, 1969, Volume: 6, Issue:3

    Topics: Acetylcholine; Animals; Antidepressive Agents; Arousal; Atropine; Barium; Duodenum; Electroencephalo

1969
[2 fatal poisonings with imipramine (Tofranil) and dibenzepin (Noveril) in small children].
    Schweizerische medizinische Wochenschrift, 1969, Aug-09, Volume: 99, Issue:32

    Topics: Child, Preschool; Dibenzazepines; Electrocardiography; Electroencephalography; Female; Gastric Lavag

1969
[Clinical course of Melipramine poisoning in 2 children].
    Ceskoslovenska pediatrie, 1969, Volume: 24, Issue:9

    Topics: Child; Child, Preschool; Electrocardiography; Electroencephalography; Enuresis; Female; Humans; Imip

1969
Fatal imipramine overdosage.
    The Medical journal of Australia, 1966, May-14, Volume: 1, Issue:20

    Topics: Adult; Female; Heart Arrest; Humans; Imipramine; Neurotic Disorders; Respiratory Insufficiency; Seiz

1966