imipramine has been researched along with Reflex, Abnormal in 6 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Reflex, Abnormal: An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 13-year-old boy with imipramine overdose developed seizures, respiratory arrest, and coma." | 7.66 | External ophthalmoplegia, alpha and spindle coma in imipramine overdose: case report and review of the literature. ( Lombroso, CT; Pulst, SM, 1983) |
| "A 13-year-old boy with imipramine overdose developed seizures, respiratory arrest, and coma." | 3.66 | External ophthalmoplegia, alpha and spindle coma in imipramine overdose: case report and review of the literature. ( Lombroso, CT; Pulst, SM, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| McGuire, EJ | 1 |
| Savastano, JA | 1 |
| Pulst, SM | 1 |
| Lombroso, CT | 1 |
| Snustad, DG | 1 |
| Rosenthal, JT | 1 |
| Zelikman, TIa | 1 |
| Shekhtman, ML | 1 |
| Sueblinvong, V | 1 |
| Wilson, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
6 other studies available for imipramine and Reflex, Abnormal
| Article | Year |
|---|---|
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Urodynamic findings and long-term outcome management of patients with multiple sclerosis-induced lower urinary tract dysfunction.
Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Female; Humans; Imipramine; Male; Mandelic Acids; M | 1984 |
External ophthalmoplegia, alpha and spindle coma in imipramine overdose: case report and review of the literature.
Topics: Adolescent; Alpha Rhythm; Brain Stem; Coma; Electroencephalography; Epilepsies, Partial; Evoked Pote | 1983 |
Urinary incontinence in the elderly.
Topics: Aged; Female; Humans; Imipramine; Mandelic Acids; Muscle, Smooth; Parasympatholytics; Propantheline; | 1985 |
[On the clinical course and therapy of pathological conditions caused by incompatible antidepressants].
Topics: Adult; Anuria; Bipolar Disorder; Bis-Trimethylammonium Compounds; Depression; Depressive Disorder, M | 1968 |
Myocardial damage due to imipramine intoxication.
Topics: Aspartate Aminotransferases; Child, Preschool; Creatine Kinase; Electrocardiography; Electroencephal | 1969 |